検索結果 3196 件
| 著者 | Hanaya, Tadashi| Iwasaki, Katsuya| |
|---|---|
| キーワード | glycosylation microcystbiopterin C pteridine pterin glycoside structural elucidation |
| 備考 | This is the peer reviewed version of the following article: T. Hanaya and K. Iwasaki, “ First Total Synthesis and Structural Elucidation of Microcystbiopterin C, a Pterin Glycoside From a Microcystis Bloom,” Journal of Heterocyclic Chemistry 63, no. 8 (2026): 1278–1287, https://doi.org/10.1002/jhet.70214., which has been published in final form at https://doi.org/10.1002/jhet.70214. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext file will be available in May 2027.| |
| 発行日 | 2026-05-22 |
| 出版物タイトル | Journal of Heterocyclic Chemistry |
| 巻 | 63巻 |
| 号 | 8号 |
| 出版者 | Wiley |
| 開始ページ | 1278 |
| 終了ページ | 1287 |
| ISSN | 0022-152X |
| NCID | AA00699237 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2026 Wiley Periodicals LLC. |
| 論文のバージョン | author |
| DOI | 10.1002/jhet.70214 |
| Web of Science KeyUT | 001771861300001 |
| 関連URL | isVersionOf https://doi.org/10.1002/jhet.70214 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Akazawa, Hidemasa| Fukushima, Shinnosuke| Miyahara, Tomoyuki| Tsuji, Shuma| Gotoh, Kazuyoshi| Ogawa, Sakura| Iio, Koji| Hagiya, Hideharu| |
| キーワード | Nocardiosis Treatment Trimethoprim–sulfamethoxazole Alternative therapy Dose modification |
| 発行日 | 2026-10 |
| 出版物タイトル | International Journal of Antimicrobial Agents |
| 巻 | 67巻 |
| 号 | 10号 |
| 出版者 | Elsevier BV |
| 開始ページ | 107906 |
| ISSN | 0924-8579 |
| NCID | AA10778078 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2026 The Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 42409130 |
| DOI | 10.1016/j.ijantimicag.2026.107906 |
| Web of Science KeyUT | 001833698900001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.ijantimicag.2026.107906 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Tran, Thi Hai Yen| Kurita, Yoshihiko| Kondo, Maiko| Fukushima, Yosuke| Shigemitsu, Yusuke| Kawamoto, Yuya| Hara, Mayuko| Tsukahara, Hirokazu| Iwasaki, Tatsuo| Kasahara, Shingo| Baba, Kenji| |
| キーワード | Fontan operation Spontaneous fenestration closure Fenestration recreation Longitudinal hemodynamic changes |
| 発行日 | 2026-05-09 |
| 出版物タイトル | Pediatric Cardiology |
| 出版者 | Springer Science and Business Media LLC |
| ISSN | 0172-0643 |
| NCID | AA00361536 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2026 |
| 論文のバージョン | publisher |
| PubMed ID | 42105109 |
| DOI | 10.1007/s00246-026-04274-4 |
| Web of Science KeyUT | 001761259600001 |
| 関連URL | isVersionOf https://doi.org/10.1007/s00246-026-04274-4 |
| タイトル（別表記） | The structure-function relationship of bacterial collagenases and its clinical applications |
|---|---|
| 著者 | 松下 治| |
| キーワード | コラーゲン Ｘ線結晶解析 クライオ電子顕微鏡 生理活性物質 マトリックス・アンカリング |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2026-08-03 |
| 巻 | 138巻 |
| 号 | 2号 |
| 開始ページ | 50 |
| 終了ページ | 57 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.138.50 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2026 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.138.50 |
| タイトル（別表記） | Striving to establish a leading national research center of infectious diseases |
|---|---|
| 著者 | 萩谷 英大| |
| キーワード | 臨床感染症 感染制御 薬剤耐性 ゲノム解析 データサイエンス |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2026-08-03 |
| 巻 | 138巻 |
| 号 | 2号 |
| 開始ページ | 45 |
| 終了ページ | 49 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.138.45 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2026 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.138.45 |
| タイトル（別表記） | Intestinal homeostasis and autoimmune arthritis mediated by type 3 immunity |
|---|---|
| 著者 | 廣田 圭司| |
| キーワード | 3型免疫 炎症性サイトカイン 組織炎症 Th17細胞 |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2026-08-03 |
| 巻 | 138巻 |
| 号 | 2号 |
| 開始ページ | 40 |
| 終了ページ | 44 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.138.40 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2026 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.138.40 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Uchida, Daisuke| Honda, Yu| Kojima, Shigeki| Miyake, Hiromasa| Nishimoto, Masatoshi| Hishikawa, Akihito| Tonomura, Shun| Sofue, Tadashi| Fujii, Naohiko| Saitoh, Masakazu| Narita, Ichiei| Yamagata, Kunihiro| Hoshino, Junichi| Kawarazaki, Hiroo| Sakurada, Tsutomu| |
| キーワード | Intradialytic exercise Physical performance Exercise period Short physical performance battery Handgrip strength Systematic review Meta-analysis |
| 発行日 | 2026-04-03 |
| 出版物タイトル | Renal Replacement Therapy |
| 巻 | 12巻 |
| 号 | 1号 |
| 出版者 | Springer Science and Business Media LLC |
| 開始ページ | 19 |
| ISSN | 2059-1381 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2026. |
| 論文のバージョン | publisher |
| DOI | 10.1186/s41100-026-00716-0 |
| Web of Science KeyUT | 001732879200001 |
| 関連URL | isVersionOf https://doi.org/10.1186/s41100-026-00716-0 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Honda, Yu| Uchida, Daisuke| Kojima, Shigeki| Miyake, Hiromasa| Nishimoto, Masatoshi| Hishikawa, Akihito| Tonomura, Shun| Sofue, Tadashi| Fujii, Naohiko| Saitoh, Masakazu| Narita, Ichiei| Yamagata, Kunihiro| Hoshino, Junichi| Kawarazaki, Hiroo| Sakurada, Tsutomu| |
| キーワード | Hemodialysis Exercise therapy Intradialytic exercise Health-related quality of life Fatigue Depression Randomized controlled trials Meta-analysis |
| 発行日 | 2026-03-08 |
| 出版物タイトル | Renal Replacement Therapy |
| 巻 | 12巻 |
| 号 | 1号 |
| 出版者 | Springer Science and Business Media LLC |
| 開始ページ | 13 |
| ISSN | 2059-1381 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2026. |
| 論文のバージョン | publisher |
| DOI | 10.1186/s41100-026-00710-6 |
| Web of Science KeyUT | 001711622100001 |
| 関連URL | isVersionOf https://doi.org/10.1186/s41100-026-00710-6 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Kon, Tetsuo| Kataoka, Kosuke| Luo, Yi‐Jyun| Wibisana, Johannes Nicolaus| Toga, Kouhei| Uno, Narumi| Monden, Yuki| Hamada, Mayuko| |
| キーワード | chromosome-level genome assembly genome evolution Hi–C scaffolding long-read sequencing non-model animals |
| 発行日 | 2026-08-21 |
| 出版物タイトル | Genes to Cells |
| 巻 | 31巻 |
| 号 | 5号 |
| 出版者 | Wiley |
| 開始ページ | e70145 |
| ISSN | 1356-9597 |
| NCID | AA11078945 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2026 The Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 42629966 |
| DOI | 10.1111/gtc.70145 |
| 関連URL | isVersionOf https://doi.org/10.1111/gtc.70145 |
| 著者 | Takeuchi, Shuhei| Nakagawa, Shota| Shinzato, Yoshifumi| Minoda, Tadashi| Ohtsuka, Naotaka| Okayasu, Mitsuhiro| |
|---|---|
| キーワード | upgrading technique Al–Si alloy primary Si segregation unidirectional solidification |
| 備考 | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s40962-026-02100-4| This fulltext file will be available in Aug. 2027.| |
| 発行日 | 2026-08-19 |
| 出版物タイトル | International Journal of Metalcasting |
| 出版者 | Springer Science and Business Media LLC |
| ISSN | 1939-5981 |
| NCID | AA12354742 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2026 American Foundry Society |
| 論文のバージョン | author |
| DOI | 10.1007/s40962-026-02100-4 |
| Web of Science KeyUT | 001853593100001 |
| 関連URL | isVersionOf https://doi.org/10.1007/s40962-026-02100-4 |
| 著者 | Nishimura, Noriyuki| Ushiyama, Sho| Otagiri, Masato| Satoh, Kouji| Suzuki, Nahomi| Irisa, Tomoko| Mitsuda, Nobutaka| Umezawa, Taishi| Nishimura, Hideki| Nemoto, Keiichirou| Tsuchiya, Wataru| Yano, Ryoichi| Sawasaki, Tatsuya| Yamazaki, Toshimasa| Hirayama, Takashi| |
|---|---|
| キーワード | ABA AHG1 AFP ABI5 DOG1 seed dormancy seed germination Arabidopsis thaliana |
| 備考 | This is the peer reviewed version of the following article: Nishimura, N., Ushiyama, S., Otagiri, M., Satoh, K., Suzuki, N., Irisa, T., Mitsuda, N., Umezawa, T., Nishimura, H., Nemoto, K., Tsuchiya, W., Yano, R., Sawasaki, T., Yamazaki, T. and Hirayama, T. (2026), AHG1–AFP interaction as a regulatory node in the ABA response during seed germination. Plant J, 127: e71081. https://doi.org/10.1111/tpj.71081, which has been published in final form at https://doi.org/10.1111/tpj.71081. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited| This fulltext file will be available in Aug. 2027.| |
| 発行日 | 2026-08 |
| 出版物タイトル | The Plant Journal |
| 巻 | 127巻 |
| 号 | 3号 |
| 出版者 | Wiley |
| 開始ページ | e71081 |
| ISSN | 0960-7412 |
| NCID | AA10846815 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2026 Society for Experimental Biology and John Wiley & Sons Ltd. |
| 論文のバージョン | author |
| PubMed ID | 42552582 |
| DOI | 10.1111/tpj.71081 |
| Web of Science KeyUT | 001839830400001 |
| 関連URL | isVersionOf https://doi.org/10.1111/tpj.71081 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Zhu, Yidan| Nakamoto, Shogo| Tsukioki, Takahiro| Takahashi, Yuko| Iwatani, Yoko| Iwatani, Tsuguo| Zhang, Xinfeng| Tanioka, Maki| Shien, Tadahiko| |
| キーワード | Primary angiosarcoma of the breast (PBA) complete surgical excision hierarchal levels of scientific evidence literature review |
| 発行日 | 2024-10 |
| 出版物タイトル | Chinese Clinical Oncology |
| 巻 | 13巻 |
| 号 | 5号 |
| 出版者 | AME Publishing Company |
| 開始ページ | 68 |
| ISSN | 2304-3865 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © AME Publishing Company. |
| 論文のバージョン | publisher |
| PubMed ID | 39260429 |
| DOI | 10.21037/cco-24-16 |
| Web of Science KeyUT | 001411242500011 |
| 関連URL | isVersionOf https://doi.org/10.21037/cco-24-16 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Iida, Yuya| Watanabe, Satoshi| |
| キーワード | Particle formation pathway Nucleation Crystallization Pre-nucleation cluster Two-step nucleation Aggregation |
| 発行日 | 2026-12 |
| 出版物タイトル | Advances in Colloid and Interface Science |
| 巻 | 358巻 |
| 出版者 | Elsevier BV |
| 開始ページ | 104018 |
| ISSN | 0001-8686 |
| NCID | AA00512449 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2026 The Authors. |
| 論文のバージョン | publisher |
| PubMed ID | 42628318 |
| DOI | 10.1016/j.cis.2026.104018 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.cis.2026.104018 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Ohnishi, Takuma| Wakiguchi, Hiroyuki| Ishimori, Shingo| Itoh, Naohiro| Yashiro, Masato| Yamazaki, Susumu| Okafuji, Ikuo| Ohtomo, Yoshiyuki| Kobayashi, Ichiro| |
| キーワード | Bacille Calmette–Guérin diphtheria, pertussis, and tetanus vaccine hepatitis A virus vaccine hepatitis B virus vaccine human papillomavirus vaccine inactivated polio vaccine influenza vaccine measles, mumps, and rubella vaccine pneumococcal vaccine varicella zoster virus vaccine |
| 発行日 | 2025-07-25 |
| 出版物タイトル | Modern Rheumatology |
| 巻 | 36巻 |
| 号 | 1号 |
| 出版者 | Oxford University Press (OUP) |
| 開始ページ | 97 |
| 終了ページ | 112 |
| ISSN | 1439-7595 |
| NCID | AA1157187X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © Japan College Rheumatology 2025. |
| 論文のバージョン | publisher |
| PubMed ID | 40709824 |
| DOI | 10.1093/mr/roaf069 |
| Web of Science KeyUT | 001551830200001 |
| 関連URL | isVersionOf https://doi.org/10.1093/mr/roaf069 |
| JaLCDOI | 10.18926/AMO/71071 |
|---|---|
| フルテキストURL | 80_4_265.pdf |
| 著者 | Yamasaki, Takuto| Sugaya, Akiko| Naoi, Yuto| Kariya, Shin| Ando, Mizuo| |
| 抄録 | Cochlear implantation (CI) in patients with CHARGE syndrome presents unique surgical challenges due to complex external, middle, and inner ear malformations. We describe the case of a 3-year-old Japanese boy for whom simultaneous transcanal CI under endoscopic guidance and external auditory canal closure were performed. This approach enabled safe electrode placement and resulted in favorable auditory outcomes, representing a potential novel surgical option for CI in patients with CHARGE syndrome. There are few reports of this type of surgical intervention, and the present case highlights the feasibility and clinical benefits of individualized surgical planning for CI in anatomically complex patients. |
| キーワード | CHARGE syndrome cochlear implantation transcanal approach temporal bone anomaly pediatric otologic surgery |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-08 |
| 巻 | 80巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 265 |
| 終了ページ | 270 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| JaLCDOI | 10.18926/AMO/71070 |
|---|---|
| フルテキストURL | 80_4_259.pdf |
| 著者 | Yabuno, Satoru| Yunoki, Masatoshi| Takeuchi, Saori| Hirashita, Koji| |
| 抄録 | Diffuse idiopathic skeletal hyperostosis (DISH) predisposes the spine to highly unstable fractures because of long lever-arm biomechanics. Unstable injuries, including AO Spine Osteoporotic Fracture (OF) type 5, are typically treated with long-segment posterior instrumentation; however, pedicle-screw fixation may be infeasible in very elderly patients with severe osteoporosis, critically narrow pedicles, and/or significant comorbidities. A 93-year-old Japanese woman presented with severe back pain without apparent trauma. Computed tomography (CT) revealed a T12 fracture with DISH, classified as OF5. The pedicles were critically narrow (3.7-4.1 mm), and dual-energy X-ray absorptiometry confirmed severe osteoporosis. Because conventional pedicle-screw fixation was considered technically unsafe and excessively invasive, limited posterior stabilization was performed using a single spinous process plate spanning T10-L1. The operative time was 48 min and the estimated blood loss was 10 ml. Immediate postoperative CT confirmed appropriate implant positioning and maintained alignment. At the 1-year follow-up, CT demonstrated solid bony union with preserved alignment and no implant failure; the patient had remained pain-free and ambulatory. This case demonstrates that spinous process-plate fixation can be a minimally invasive salvage option for carefully selected very-elderly patients with DISH when pedicle-screw instrumentation is not feasible. |
| キーワード | DISH vertebral fracture osteoporosis spinous process plate |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-08 |
| 巻 | 80巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 259 |
| 終了ページ | 264 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| レファレンス | Resnick D and Niwayama G: Radiographic and pathologic features of spinal involvement in diffuse idiopathic skeletal hyperostosis (DISH). Radiology (1976) 119: 559-568.| Wu Y, Ye Q, He D, Wei Y, Pan Y and Wang Y: Effect of Diffuse Idiopathic Skeletal Hyperostosis on the Occurrence of Thoracolumbar Vertebral Fragility Fractures at Different Ages. Global Spine J (2025) 15: 2075-2086.| Harlianto NI, Ezzafzafi S, Foppen W, Kuperus JS, van der Horst-Bruinsma IE, de Jong PA and Verlaan JJ: The prevalence of vertebral fractures in diffuse idiopathic skeletal hyperostosis and ankylosing spondylitis: A systematic review and meta-analysis. N Am Spine Soc J (2024) 17: 100312.| Blattert TR, Schnake KJ, Gonschorek O, Gercek E, Hartmann F, Katscher S, Mork S, Morrison R, Muller M, Partenheimer A, Piltz S, Scherer MA, Ullrich BW, Verheyden A, Zimmermann V and the Spine Section of the German Society for Orthopaedics and Trauma. Nonsurgical and Surgical Management of Osteoporotic Vertebral Body Fractures: Recommendations of the Spine Section of the German Society for Orthopaedics and Trauma (DGOU). Global Spine J (2018) 8: 50-55.| Tomii M, Itoh Y, Numazawa S, Watanabe K and Nakagawa H: Spinous process plate (S-plate) fixation after posterior interbody fusion for lumbar canal stenosis due to spondylolisthesis. Neurosurg Rev (2013) 36: 139-143.| Diederichs G, Engelken F, Marshall LM, Peters K, Black DM, Issever AS, Barrett-Connor E, Orwoll E, Hamm B, Link TM and Osteoporotic Fractures in Men (MrOs) Research Group: Diffuse idiopathic skeletal hyperostosis (DISH): relation to vertebral fractures and bone density. Osteoporos Int (2011) 22: 1789-1797.| Page PS, Greeneway GP, Lake WB, Brooks NP, Josiah DT, Hanna AS and Resnick DK: Outcomes following conservative treatment of extension fractures in the setting of diffuse idiopathic skeletal hyperostosis: is external orthosis alone a reasonable option? J Neurosurg Spine (2022) 37: 927-931.| Solitro GF, Whitlock K, Amirouche F, Mehta AI and McDonnell A: Currently Adopted Criteria for Pedicle Screw Diameter Selection. Int J Spine Surg (2019) 13: 132-145.| Matsukawa K, Yato Y, Hynes RA, Imabayashi H, Hosogane N, Asazuma T, Matsui T, Kobayashi Y and Nemoto K: Cortical Bone Trajectory for Thoracic Pedicle Screws: A Technical Note. Clin Spine Surg (2017) 30: 497-504.| Wang H, Wang H, Sribastrav SS, Ye F, Liang C, Li Z, Wang J, Liu H, Wang X and Zheng Z: Comparison of pullout strength of the thoracic pedicle screw between intrapedicular and extrapedicular technique: a meta-analysis and literature review. Int J Clin Exp Med (2015) 8: 22237-22245.| Ikuma H, Takao S, Inoue Y, Hirose T, Matsukawa K and Kawasaki K: Treatment of Thoracolumbar Spinal Fracture Accompanied by Diffuse Idiopathic Skeletal Hyperostosis Using Transdiscal Screws for Diffuse Idiopathic Skeletal Hyperostosis: Preliminary Results. Asian Spine J (2021) 15: 340-348.| Hishiya T, Ishikawa T and Ota M: Posterior spinal fixation using penetrating endplate screws in patients with diffuse idiopathic skeletal hyperostosis-related thoracolumbar fractures. J Neurosurg Spine (2021) 34: 936-941.| Nakao Y SS, Kimura M, Yamada T, Yamamoto Y and Takashiba K: Spinal fusion using a spinous process plate (S-plate)- clinical results and mechanical strength. The journal of the Japan Spine Research Society (2006) 17: 119.| Ugawa R, Fujiwara Y and Matsumoto T: Clinical Outcomes of Transdiscal Screws for Thoracolumbar Spinal Fractures with Marked Anterior Distraction Gap Accompanied by Diffuse Idiopathic Skeletal Hyperostosis. Medicina (Kaunas) (2025) 61: 1-9.| |
| JaLCDOI | 10.18926/AMO/71069 |
|---|---|
| フルテキストURL | 80_4_253.pdf |
| 著者 | Ishikami, Sachiko| Tamura, Shuta| Tabuchi, Motoyasu| Yamamoto, Nao| Okamoto, Yuki| Yoshimatsu, Rika| Matsumoto, Manabu| Iwata, Jun| Okabayashi, Takehiro| |
| 抄録 | Lymphangioma is a benign tumor arising from lymphatic vessel proliferation and most commonly occurs in the head, neck, or axilla. Involvement of the small intestine is rare and is often overlooked as a source of obscure gastrointestinal bleeding. Because jejunal lymphangiomas frequently present with nonspecific symptoms and may escape detection by conventional upper and lower gastrointestinal endoscopy or cross-sectional imaging, diagnosis is often delayed. Advances in balloon-assisted enteroscopy have enabled direct visualization of small intestinal lesions, facilitating accurate diagnosis and appropriate therapeutic decision-making. Here, we report a case of jejunal lymphangioma presenting with severe anemia due to active bleeding, which was detected by double-balloon endoscopy and successfully managed by laparoscopic-assisted resection. This case highlights the importance of considering small intestinal lymphangioma in the differential diagnosis of unexplained gastrointestinal bleeding and underscores the clinical utility of deep enteroscopy in identifying rare but clinically significant small bowel tumors. |
| キーワード | jejunal lymphangioma double-balloon endoscopy surgery |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-08 |
| 巻 | 80巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 253 |
| 終了ページ | 257 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| レファレンス | Galifer RB, Pous JG, Juskiewenski S, Pasquie M and Gaubert J: Intra-abdominal cystic lymphangiomas in childhood. Prog Pediatr Surg (1978) 11: 173-238.| Chin CC, Shiau J, Luo CW and Hou MF: Lymphangioma of the small bowel in adults: a rare cause of abdominal symptoms. Asian J Surg (2023) 46: 863-867.| Kida A, Matsuda K, Hirai S, Shimatani A, Horita Y, Hiramatsu K, Matsuda M, Ogino H, Ishizawa S and Noda Y: A pedunculated polyp-shaped small-bowel lymphangioma causing gastrointestinal bleeding and treated by double-balloon enteroscopy. World J Gastroenterol (2012) 18: 4798-4800.| Zhao N, Fu Y, Wang Z, An Q and Jia W: Submucosal cavernous lymphangioma causing jejuno-jejunal intussusception in an adult: a case report. Front Surg (2022) 9: 953840.| Hanagiri T, Baba M, Shimabukuro T, Hashimoto M, Takemoto H, Inoue A, Sugitani A and Shirakusa T: Lymphangioma in the small intestine: report of a case and review of the Japanese literature. Surg Today (1992) 22: 363-367.| Cheung DY and Choi MG: Current advances in small bowel tumors. Clin Endosc (2011) 44: 13-21.| Yamamoto H, Sekine Y, Sato Y, Higashizawa T, Miyata T, Iino S, Ido K and Sugano K: Total enteroscopy with a nonsurgical steerable double-balloon method. Gastrointest Endosc (2001) 53: 216-220.| Pennazio M, Spada C, Eliakim R, Keuchel M, May A, Mulder CJ, Rondonotti E, Adler SN, Albert J, Baltes P, Barbaro F, Cellier C, Charton JP, Delvaux M, Despott EJ, Domagk D, Klein A, McAlindon M, Rosa B, Rowse G, Sanders DS, Saurin JC, Sidhu R, Dumonceau JM, Hassan C and Gralnek IM: Small-bowel capsule endoscopy and device-assisted enteroscopy. Endoscopy (2015) 47: 352-376.| Peters FT, Rutgers EJ and Driessen WM: Intra-abdominal lymphangiomatous cysts in adults. Neth J Med (1987) 31: 152-157.| Wang ZZ, Shen LY, Zhou JJ, Tang JL, Ye LP, Shen CB, Li SW and Zhou XB: Clinical manifestation and treatment of small intestinal lymphangioma: a single-center analysis of 15 cases. Front Med (Lausanne) (2022) 9: 975698.| Iwabuchi A, Otaka M, Okuyama A, Jin M, Otani S, Itoh S, Sasahara H, Odashima M, Kotanagi H, Satoh M, Masuda H and Masamune O: Disseminated intra-abdominal cystic lymphangiomatosis with severe intestinal bleeding: a case report. J Clin Gastroenterol (1997) 25: 383-386.| Tan B, Zhang SY, Wang YN, Li Y, Shi XH and Qian JM: Jejunal cavernous lymphangioma manifested as gastrointestinal bleeding with hypogammaglobulinemia in an adult: a case report and literature review. World J Clin Cases (2020) 8: 140-148.| Meşină C, Paşalega M, Calotă F, Comănescu V, Vîlcea D, Tenea T, Mirea C and Vasile I: Hemorrhagic intestinal lymphangioma: report of a case. Chirurgia (Bucur) (2006) 101: 201-204.| Lim DR, Kuk JC, Kim T and Shin EJ: Surgery of multiple lymphangioma in the small bowel: a rare case report of chronic gastrointestinal bleeding. Ann Surg Treat Res (2018) 94: 52-56.| Barquist ES, Apple SK, Jensen DM and Ashley SW: Jejunal lymphangioma: an unusual cause of chronic gastrointestinal bleeding. Dig Dis Sci (1997) 42: 1179-1183.| Xiao NJ, Ning SB, Li T, Li BR and Sun T: Small intestinal hemolymphangioma treated with enteroscopic injection sclerotherapy: a case report and review of the literature. World J Gastroenterol (2020) 26: 1540-1545.| Yang J, Zhang Y, Kou G and Li Y: Jejunum hemolymphangioma causing refractory anemia in a young woman. Am J Gastroenterol (2020) 115: 810.| Yang SX, Zhou YH, Zhang J, Miao L, Zhong JW, Wang WX, Xu CL, Cai ZZ and Lu GR: Haemorrhagic ileal haemolymphangioma: a case report and review of the literature. J Int Med Res (2021) 49: 300060520986677.| Tomizawa Y, Garner K and Sohnen A: Lymphangioma of the small bowel mesentery: a rare intra-abdominal tumor causing anemia. Clin Gastroenterol Hepatol (2013) 11: e57.| Fang YF, Qiu LF, Du Y, Jiang ZN and Gao M: Small intestinal hemolymphangioma with bleeding: a case report. World J Gastroenterol (2012) 18: 2145-2146.| Park JG, Aubry MC, Godfrey JA and Midthun DE: Mediastinal lymphangioma: Mayo Clinic experience of 25 cases. Mayo Clin Proc (2006) 81: 1197-1203.| Landing BH and Farber S: Tumors of the cardiovascular system. Atlas of tumor pathology Armed forces Inst. Path. Washington D. C 1956.| |
| JaLCDOI | 10.18926/AMO/71068 |
|---|---|
| フルテキストURL | 80_4_247.pdf |
| 著者 | Shiina, Tsuyoshi| Watanabe, Hirokazu| Yoshimoto, Junko| Sato, Takeshi| Morimoto, Daisaku| Okamura, Tomoka| Tanimoto, Terutaka| Washio, Yosuke| Oyama, Takanori| Tsukahara, Hirokazu| Noda, Takuo| |
| 抄録 | The long-term survival of individuals with trisomy 18 has improved, and the need for tracheostomy in this population has thus increased. We describe the case of a 3-year-old Japanese boy with trisomy 18 who developed a tracheoarterial fistula involving the left common carotid artery (LCCA). He underwent an emergency tracheostomy for respiratory failure secondary to pneumonia. Massive hemorrhage from the tracheostoma occurred on postoperative day 31, leading to his death. The autopsy revealed that the LCCA originated from the brachiocephalic trunk and coursed medially, forming a fistulous connection with the trachea. This case highlights the clinical importance of preoperative vascular mapping in patients with chromosomal abnormalities. |
| キーワード | tracheoarterial fistula tracheocarotid fistula trisomy 18 |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-08 |
| 巻 | 80巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 247 |
| 終了ページ | 252 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| JaLCDOI | 10.18926/AMO/71067 |
|---|---|
| フルテキストURL | 80_4_241.pdf |
| 著者 | Hasegawa, Yuta| Tsujimoto, Hironori| Uehata, Naoyuki| Kariya, Risa| Ide, Asuma| Suzuki, Takafumi| Fujishima, Seiichiro| Kouzu, Keita| Yaguchi, Yoshihisa| Miyai, Kosuke| Kurihara, Ayumu| Ogata, Sho| Matsukuma, Susumu| Ueno, Hideki| |
| 抄録 | Primary hyperparathyroidism (pHPT) is typically caused by a parathyroid adenoma, although some cases arise from ectopic glands. Accurate preoperative localization is essential for guiding surgical strategy, particularly for mediastinal lesions. We report successful video-assisted thoracoscopic surgery (VATS) for an upper mediastinal parathyroid adenoma. A 68-year-old woman was referred for hypercalcemia during evaluation for recurrent ureteral stones. Laboratory tests revealed elevated serum calcium (13.2 mg/dl) and intact parathyroid hormone (iPTH) levels (266 pg/ml). Contrast-enhanced computed tomography, magnetic resonance imaging, and 99mTc-methoxyisobutylisonitrile scintigraphy identified a 20-mm mass adjacent to the right esophageal wall. VATS was performed due to the tumor’s mediastinal location. The lesion was resected with intraoperative nerve monitoring (IONM) to avoid recurrent laryngeal nerve damage. Postoperatively, iPTH and calcium levels rapidly normalized. Transient hypocalcemia and mild hoarseness occurred but resolved with calcium supplementation and conservative management. Pathological examination confirmed a parathyroid adenoma without malignancy. VATS offers a safe and minimally invasive approach for upper mediastinal parathyroid adenomas. IONM and vigilant calcium management are crucial for minimizing these complications. This case highlights the importance of comprehensive imaging, surgical planning, and postoperative care in managing upper mediastinal pHPT. |
| キーワード | primary hyperparathyroidism parathyroid neoplasm ectopic tissue video-assisted thoracoscopic surgery |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-08 |
| 巻 | 80巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 241 |
| 終了ページ | 246 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| JaLCDOI | 10.18926/AMO/71066 |
|---|---|
| フルテキストURL | 80_4_233.pdf |
| 著者 | Ogawa, Sakura| Fukushima, Shinnosuke| Akazawa, Hidemasa| Namba, Sachie| Hirota, Chiyoko| Kishiue, Tomoyoshi| Ibara, Shohei| Kondo, Takayuki| Fukuda, Genshi| Iio, Koji| Tsuji, Shuma| Gotoh, Kazuyoshi| Otsuka, Fumio| Hagiya, Hideharu| |
| 抄録 | Carbapenemase-producing Enterobacterales (CPE) and extended-spectrum β-lactamase (ESBL)-producing Enterobacterales (ESBL-E) are representative antimicrobial-resistant pathogens. We investigated the prevalence of CPE and ESBL-E in Okayama, Japan to clarify their current epidemiology and potential clinical burden. Active surveillance for CPE and ESBL-E was performed first, using stool samples submitted to the Okayama Medical Laboratory (Japan) in the years 2024-2025. Screening was performed using a selective agar (CHROMagar mSuper CARBA/ESBL). Phenotypic identification was conducted with the use of a modified carbapenem inactivation method and double-disk phenotypic confirmatory tests. Clinical information including patient age, sex, sampling date, and hospital address were collected, and the data were analyzed according to specimen origin (hospitals, clinics, and health checkups). A total of 2,000 stool samples were screened, of which two CPE isolates (0.1%) and 285 ESBL-E isolates (14.3%) were identified. By specimen origin, the ESBL-E positivity rate was significantly higher in hospitals (17.4%) than in clinics (11.8%). By age category, the late elderly (> 75 years) exhibited the highest ESBL-E positivity rate (22.6%) compared to other age groups. In the clinics and health checkups, infants (0 years) demonstrated high ESBL-E positivity rates (18.2% and 14.3%, respectively). Escherichia coli was the most common ESBL-E organism in the hospitals (77.2%), clinics (88.8%), and health checkups (87.5%). Our active screening demonstrated that the prevalences of CPE and ESBL-E were within the reported ranges; however, in this era of increasing internationalization, continuous surveillance of these notifiable pathogens is warranted. |
| キーワード | antimicrobial resistance carbapenem-resistant Enterobacteriaceae extended-spectrum β-lactamase infection prevention and control Okayama Medical Laboratory |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-08 |
| 巻 | 80巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 233 |
| 終了ページ | 240 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| レファレンス | Jean SS, Harnod D and Hsueh PR: Global threat of carbapenem-resistant Gram-negative bacteria. Front Cell Infect Microbiol (2022) 12: 823684.| Baek MS, Kim JH, Park JH, Kim TW, Jung HI and Kwon YS: Comparison of mortality rates in patients with carbapenem-resistant Enterobacterales bacteremia according to carbapenemase production: a multicenter propensity-score matched study. Sci Rep (2024) 14: 597.| Takei K, Ogawa M, Sakata R and Kanamori H: Epidemiological characteristics of carbapenem-resistant Enterobacterales in Japan: a nationwide analysis of data from a clinical laboratory center (2016-2022). Pathogens (2023) 12: 1246.| Yamamoto N, Asada R, Kawahara R, Hagiya H, Akeda Y and Shanmugakani RK: Prevalence of, and risk factors for, carriage of carbapenem-resistant Enterobacteriaceae among hospitalized patients in Japan. J Hosp Infect (2017) 97: 212-217.| Hagiya H, Yamamoto N, Kawahara R, Akeda Y, Shanmugakani RK and Ueda A: Risk factors for fecal carriage of IMP-6-producing Enterobacteriaceae at a long-term care hospital in Japan: a follow-up report from the northern Osaka multicentre study group. J Infect Chemother (2018) 24: 769-772.| Ohno Y, Nakamura A, Hashimoto E, Noguchi N, Matsumoto G and Fukuda S: Fecal carriage and molecular epidemiologic characteristics of carbapenemase-producing Enterobacterales in a primary care hospital in a Japanese city. J Infect Chemother (2020) 26: 928-932.| Ishii Y, Aoki K, Tateda K and Kiyota H: Multicenter collaboration study on the β-lactam-resistant Enterobacteriaceae in Japan ‒ the 65th anniversary public interest purpose project of the Japanese Society of Chemotherapy. J Infect Chemother (2017) 23: 583-586.| Nakai M, Oka K, Watanabe G, Kamei K, Tsukada N and Mori R: Epidemiology and molecular characterization of fecal carriage of third-generation cephalosporin-resistant Enterobacterales among elderly residents in Japan. J Infect Chemother (2022) 28: 569-575.| Hagiya H, Onishi Y, Shinohara N, Tokuyasu M, Imanishi A and Fukushima S: High frequency of extended-spectrum beta-lactamase-producing Enterobacteriaceae carriers at a Japanese long-term care hospital. J Infect Chemother (2022) 28: 1578-1581.| Fukushima S, Hagiya H, Uda K, Gotoh K and Otsuka F: Current prevalence of antimicrobial resistance in Okayama from a national database between 2018 and 2021. Acta Med Okayama (2023) 77: 255-262.| Fukushima S, Hagiya H, Gotoh K, Tsuji S, Iio K and Matsushita O: Detection of imported clinical strain of blaNDM-1-harbouring ST147 Klebsiella pneumoniae from a Ukrainian immigrant. J Travel Med (2024) 31: taae011.| Gotoh K, Hagiya H, Iio K, Yamada H, Matsushita O and Otsuka F: Detection of Enterobacter cloacae complex strain with a blaNDM-1-harboring plasmid from an elderly resident at a long-term care facility in Okayama, Japan. J Infect Chemother (2022) 28: 1697-1699.| Gotoh K, Miyoshi M, I Putu Bayu Mayura, Tsuji S, Iio K and Fukushima S: Phenotypic and genetic characteristics of carbapenemase-producing Enterobacterales isolates at Okayama University Hospital. Acta Med Okayama (2024) 78: 371-376.| Pierce VM, Simner PJ, Lonsway DR, Roe-Carpenter DE, Johnson JK and Brasso WB: Modified carbapenem inactivation method for phenotypic detection of carbapenemase production among Enterobacteriaceae. J Clin Microbiol (2017) 55: 2321-2333.| Kanda Y: Investigation of the freely available easy-to-use software “EZR” for medical statistics. Bone Marrow Transplant (2013) 48: 452-458.| Bezabih YM, Bezabih A, Dion M, Batard E, Teka S and Obole A: Comparison of the global prevalence and trend of human intestinal carriage of ESBL-producing Escherichia coli between healthcare and community settings: a systematic review and meta-analysis. JAC Antimicrob Resist (2022) 4: dlac048.| Ng RWY, Yang L, Lau SH, Hawkey P and Ip M: Global prevalence of human intestinal carriage of ESBL-producing Escherichia coli during and after the COVID-19 pandemic. JAC Antimicrob Resist (2025) 7: dlaf001.| Raffelsberger N, Buczek DJ, Svendsen K, Småbrekke L, Pöntinen AK and Löhr IH: Community carriage of ESBL-producing Escherichia coli and Klebsiella pneumoniae: a cross-sectional study of risk factors and comparative genomics of carriage and clinical isolates. mSphere (2023) 8: e00025-23.| Islam K, Heffernan AJ, Naicker S, Henderson A, Chowdhury MAH and Roberts JA: Epidemiology of extended-spectrum β-lactamase and metallo-β-lactamase-producing Escherichia coli in South Asia. Future Microbiol (2021) 16: 521-535.| Rahaman A, Mimi A, Antor MTH, Bakhtiyar Z, Hasan MAE and Fahim NAI: Prevalence of extended-spectrum beta-lactamase-producing Enterobacteriaceae isolated from animals in Bangladesh: a systematic review and meta-analysis. One Health (2025) 21: 101237.| Xie Y, Srivastava IM, Jing F, Ma C, Wu X, Chen Y, Du Y, Low XYC, Ping Y, Pan J, Gupta A, Graves N and Mo Y: One Health perspective of antibiotic resistance in Enterobacterales from Southeast Asia: a systematic review and meta-analysis. Res Sq (2025) 16: 1694.| Jia P, Zhu Y, Li X, Kudinha T, Yang Y and Zhang G: High prevalence of extended-spectrum beta-lactamases in Escherichia coli strains collected from strictly defined community-acquired urinary tract infections in adults in China: a multicenter prospective clinical microbiological and molecular study. Front Microbiol (2021) 12: 663033.| Chao CM, Lai CC and Yu WL: Epidemiology of extended-spectrum β-lactamases in Enterobacterales in Taiwan for over two decades. Front Microbiol (2022) 13: 1060050.| Chaisaeng S, Chopjitt P, Kasemsiri P, Putthanachote N, Boueroy P and Takeuchi D: High prevalence of ESBL-producing Escherichia coli phylogroup B2 clinical isolates in northeastern Thailand. BMC Microbiol (2024) 24: 425.| Sawatwong P, Sapchookul P, Whistler T, Gregory CJ, Sangwichian O and Makprasert S: High burden of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae bacteremia in older adults: a seven-year study in two rural Thai provinces. Am J Trop Med Hyg (2019) 100: 943-951.| Sunarno S, Puspandari N, Fitriana F, Nikmah UA, Idrus HH and Panjaitan NSD: Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in Indonesia and Southeast Asian countries: GLASS data 2018. AIMS Microbiol (2023) 9: 218-227.| Kawamura K, Nagano N, Suzuki M, Wachino JI, Kimura K and Arakawa Y: ESBL-producing Escherichia coli and its rapid rise among healthy people. Food Saf (2017) 5: 122-150.| Shibuki R, Nishiyama M, Mori M, Baba H, Kanamori H and Watanabe T: Characterization of extended-spectrum β-lactamase-producing Escherichia coli isolated from municipal and hospital wastewater in Japan. J Glob Antimicrob Resist (2023) 32: 145-151.| Kawata S, Morimoto S, Kosai K, Kawamoto Y, Nakashima Y and Morinaga Y: The fecal carriage rate of extended-spectrum β-lactamase-producing or carbapenem-resistant Enterobacterales among Japanese infants in the community at the 4-month health examination in a rural city. Front Cell Infect Microbiol (2023) 13: 1168451.| |