検索結果 - 岡山大学学術成果リポジトリ

Comprehensive Comparative Genomics and Phenotyping of Methylobacterium Species

フルテキストURL	fulltext.pdf
著者	Alessa, Ola\| Ogura, Yoshitoshi\| Fujitani, Yoshiko\| Takami, Hideto\| Hayashi, Tetsuya\| Sahin, Nurettin\| Tani, Akio\|
キーワード	Methylobacterium comparative genomics methylotroph methanol dehydrogenase Methylorubrum
発行日	2021-10-06
出版物タイトル	Frontiers In Microbiology
巻	12巻
出版者	Frontiers Media
開始ページ	740610
ISSN	1664-302X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 Alessa, Ogura, Fujitani, Takami, Hayashi, Sahin and Tani.
論文のバージョン	publisher
PubMed ID	34737731
DOI	10.3389/fmicb.2021.740610
Web of Science KeyUT	000715823300001
関連URL	isVersionOf https://doi.org/10.3389/fmicb.2021.740610

Biphasic Roles of Clock Genes and Bone Morphogenetic Proteins in Gonadotropin Expression by Mouse Gonadotrope Cells

フルテキストURL	fulltext.pdf
著者	Soejima, Yoshiaki\| Iwata, Nahoko\| Nakano, Yasuhiro\| Yamamoto, Koichiro\| Suyama, Atsuhito\| Nada, Takahiro\| Otsuka, Fumio\|
キーワード	bone morphogenetic protein (BMP) Clock gonadotropins luteinizing hormone mitogen-activated protein kinase (MAPK)
発行日	2021-10-17
出版物タイトル	International Journal of Molecular Sciences
巻	22巻
号	20号
出版者	MDPI
開始ページ	11186
ISSN	1422-0067
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 by the authors.
論文のバージョン	publisher
PubMed ID	34681844
DOI	10.3390/ijms222011186
Web of Science KeyUT	000715120500001
関連URL	isVersionOf https://doi.org/10.3390/ijms222011186

First-line pembrolizumab vs chemotherapy in metastatic non-small-cell lung cancer: KEYNOTE-024 Japan subset

フルテキストURL	fulltext.pdf
著者	Satouchi, Miyako\| Nosaki, Kaname\| Takahashi, Toshiaki\| Nakagawa, Kazuhiko\| Aoe, Keisuke\| Kurata, Takayasu\| Sekine, Akimasa\| Horiike, Atsushi\| Fukuhara, Tatsuro\| Sugawara, Shunichi\| Umemura, Shigeki\| Saka, Hideo\| Okamoto, Isamu\| Yamamoto, Nobuyuki\| Sakai, Hiroshi\| Kishi, Kazuma\| Katakami, Nobuyuki\| Horinouchi, Hidehito\| Hida, Toyoaki\| Okamoto, Hiroaki\| Atagi, Shinji\| Ohira, Tatsuo\| Han, Shi Rong\| Noguchi, Kazuo\| Ebiana, Victoria\| Hotta, Katsuyuki\|
キーワード	Japan non-small-cell lung carcinoma PD-L1 protein pembrolizumab treatment outcome
発行日	2021-09-20
出版物タイトル	Cancer Science
出版者	Wiley
ISSN	1347-9032
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 The Authors.
論文のバージョン	publisher
PubMed ID	34543477
DOI	10.1111/cas.15144
Web of Science KeyUT	000714623800001
関連URL	isVersionOf https://doi.org/10.1111/cas.15144

Characteristics of channel pores formed by Bacillus thuringiensis mosquito-larvicidal Cry4Aa toxin

フルテキストURL	fulltext20211109-2.pdf Figs20211109-2.pdf
著者	Shiraishi, Yuri\| Shiozaki, Tomoya\| Asakura, Mami\| Ide, Toru\| Hayakawa, Tohru\|
キーワード	Bacillus thuringiensis Cry4Aa toxin Culex pipiens mosquito larvae electrophysiologic analysis of channel-pores
備考	This is an Accepted Manuscript of an article published by Springer. This fulltext is available in Oct. 2022.\|
発行日	2021-10-23
出版物タイトル	Applied Entomology and Zoology
巻	57巻
号	1号
出版者	Springer Science and Business Media LLC
開始ページ	63
終了ページ	70
ISSN	0003-6862
NCID	AA00543238
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 Springer Nature Switzerland AG.
論文のバージョン	author
DOI	10.1007/s13355-021-00762-6
Web of Science KeyUT	000710605800001
関連URL	isVersionOf https://doi.org/10.1007/s13355-021-00762-6

光受容タンパク質・ロドプシンの生物物理化学研究

タイトル（別表記）	Biophysical and Biochemical Research of Animal Rhodopsins
フルテキストURL	fulltext20211102-2.pdf
著者	小島慧一\|
キーワード	rhodopsin opsin retinal G protein coupled receptor vision
発行日	2021-10-1
出版物タイトル	YAKUGAKU ZASSHI
巻	141巻
号	10号
出版者	Pharmaceutical Society of Japan
開始ページ	1155
終了ページ	1160
ISSN	0031-6903
NCID	AN00284903
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 The Pharmaceutical Society of Japan
論文のバージョン	publisher
PubMed ID	34602512
DOI	10.1248/yakushi.21-00144
Web of Science KeyUT	000708444600004
関連URL	isVersionOf https://doi.org/10.1248/yakushi.21-00144

Repurposing of posaconazole as a hedgehog/SMO signaling inhibitor for embryonal rhabdomyosarcoma therapy

フルテキストURL	fulltext.pdf
著者	Sun, Jingkai\| Lin, Wenfeng\| Li, Chaoming\| Ueki, Hideo\| Xue, Ruizhi\| Sadahira, Takuya\| Hu, Hao\| Wada, Koichiro\| Li, Na\| Liu, Chunxiao\| Araki, Motoo\| Xu, Abai\| Huang, Peng\|
キーワード	Posaconazole cell cycle autophagy rhabdomyosarcoma hedgehog proteins
発行日	2021-09-30
出版物タイトル	American Journal of Cancer Research
巻	11巻
号	9号
出版者	e-Century Publishing Corporation
開始ページ	4528
終了ページ	4540
ISSN	2156-6976
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	AJCR (c)2021 e-Century Publishing Corp.
論文のバージョン	publisher
PubMed ID	34659903
Web of Science KeyUT	000707716300029

Production of TRPM4 knockout cell line using rat cardiomyocyte H9c2

フルテキストURL	fulltext.pdf Corrigendum.pdf
著者	Wang, Chen\| Maeda, Masakazu\| Chen, Jian\| Wang, Mengxue\| Naruse, Keiji\| Takahashi, Ken\|
キーワード	TRPM4 Cardiomyocyte H9c2 CRISPR/Cas9 Confocal microscopy DNA sequencing Flow cytometry Western blotting
発行日	2021
出版物タイトル	MethodsX
巻	8巻
出版者	ELSEVIER
開始ページ	101404
ISSN	2215-0161
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 The Authors.
論文のバージョン	publisher
PubMed ID	34430300
DOI	10.1016/j.mex.2021.101404
Web of Science KeyUT	000707187100026
関連URL	isVersionOf https://doi.org/10.1016/j.mex.2021.101404

Pulmonary Enteric Adenocarcinoma Harboring a BRAF G469V Mutation

JaLCDOI	10.18926/AMO/62819
フルテキストURL	75_6_759.pdf
著者	Shimizu, Dai\| Yamamoto, Hiromasa\| Shien, Kazuhiko\| Taniguchi, Kohei\| Miyoshi, Kentaroh\| Namba, Kei\| Mesaki, Kumi\| Sugimoto, Seiichiro\| Soh, Junichi\| Yamane, Masaomi\| Toyooka, Shinichi\|
抄録	Pulmonary enteric adenocarcinoma (PEAC) is a rare subtype of lung cancer that should be differentiated from colorectal cancer metastasis. Little is known about its genetic background. An 84-year-old male with adenocarcinoma of the lung underwent left upper lobectomy. The histology of the surgical specimen was suggestive of PEAC. Gastrointestinal and colorectal fiberscopy revealed no evidence of colorectal cancer. Next-generation sequencing of the tumor identified a G469V substitution in serine/threonine-protein kinase B-raf (BRAF). Based on the higher prevalence of the G469 substitution in BRAF-mutant lung adenocarcinoma than in BRAFmutant colorectal cancer, the tumor likely originated from the lung. Identification of mutational genotype may be of some help in distinguishing PEAC from the lung metastasis of colorectal cancer.
キーワード	non-small cell lung cancer somatic mutations pulmonary adenocarcinoma with enteric differentiation non-V600E BRAF mutation next-generation sequencing
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2021-12
巻	75巻
号	6号
出版者	Okayama University Medical School
開始ページ	759
終了ページ	762
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34955547
Web of Science KeyUT	000735319800005
NAID	120007180273

Non-Invasive Prenatal Genetic Testing (NIPT) Leading to Prenatal Diagnosis of Trisomy 21 Mosaicism and 18q Deletion Syndrome: Two Cases

JaLCDOI	10.18926/AMO/62816
フルテキストURL	75_6_745.pdf
著者	Hayata, Kei\| Mishima, Sakurako\| Ohira, Akiko\| Tani, Kazumasa\| Maki, Jota\| Eto, Eriko\| Ogawa, Chikako\| Masuyama, Hisashi\|
抄録	NIPT is non-definitive testing to estimate the possibility that fetuses have trisomy 21, trisomy 18, or trisomy 13. However, in NIPT-positive and indeterminate cases, rare chromosomal disease may become apparent, requiring advanced genetic considerations and counseling skills. We experienced two such cases, a trisomy 21 mosaicism case triggered by NIPT-positive status and 18q deletion syndrome triggered by NIPT-indeterminate status. These cases have two clinical implications for NIPT. First, it was revealed that trisomy mosaicism might be found in NIPT-positive cases that have lower Z-Scores than those inferred from the fraction of fetal cfDNA in the case of standard trisomy. Second, it is possible that microdeletion syndrome could be the reason for an indeterminate NIPT result. Today’s genetic counseling requires more expertise in ethics and communication as well as genetic science because NIPT can lead to totally unexpected results.
キーワード	NIPT massively parallel sequencing trisomy 21 mosaicism 18q-deletion syndrome genetic counseling
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2021-12
巻	75巻
号	6号
出版者	Okayama University Medical School
開始ページ	745
終了ページ	750
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34955544
Web of Science KeyUT	000735319800002
NAID	120007180276

Morphological Changes and Durability of Skin and Mucosal Flaps in Intraoral and Pharyngeal Reconstructions: Long-term Follow-up and Literature Review for Potential Second Carcinomas

JaLCDOI	10.18926/AMO/62813
フルテキストURL	75_6_725.pdf
著者	Matsumoto, Hiroshi\| Kimata, Yoshihiro\| Ota, Tomoyuki\| Sugiyama, Narushi\| Onoda, Satoshi\| Makino, Takuma\| Takeda, Seiko\| Mizukawa, Nobuyoshi\|
抄録	The long-term changes in tissues implanted in the oral cavity and pharynx after head and neck reconstruction have not been fully evaluated. This study aimed to clarify the morphological changes, long-term durability, and potential for secondary carcinogenesis in such tissues. In our single-center study, the rough morphological changes in 54 cases of intraoral and pharyngeal skin and mucosal flaps were evaluated more than 10 years after flap transfer. In addition, the literature on the development of second carcinomas from skin flaps was reviewed. The mean follow-up period for transferred flaps was 148 months. The reconstruction areas and the probability of morphological changes were significantly correlated (p=0.006), especially in cases with tongue, lower gingiva, and buccal mucosal reconstruction. Free jejunal flap surfaces were well maintained, whereas tubed skin flaps showed severe morphological changes in cases with pharyngeal reconstruction. None of the flaps in our series developed second primary carcinomas. Skin flaps generally had good durability for > 10 years in intraoral environments, while mucosal flaps had better durability for pharyngeal reconstruction. Second squamous carcinomas arising from skin flaps are extremely rare; however, surgeons should take this possibility into consideration and conduct meticulous and long-term follow-up.
キーワード	skin flap mucosal flap oral reconstruction morphological change second primary carcinoma
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-12
巻	75巻
号	6号
出版者	Okayama University Medical School
開始ページ	725
終了ページ	734
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34955541
NAID	120007180279

EG-VEGF Induces Invasion of a Human Trophoblast Cell Line via PROKR2

JaLCDOI	10.18926/AMO/62806
フルテキストURL	75_6_677.pdf
著者	Tani Kazumasa\| Mitsui, Takashi\| Mishima, Sakurako\| Ohira, Akiko\| Maki, Jota\| Eto, Eriko\| Hayata, Kei\| Nakamura, Keiichiro\| Masuyama, Hisashi\|
抄録	Extravillous trophoblast (EVT) invasion is important for embryo implantation, placental development, and successful remodeling of the uterine spiral artery. Endocrine gland derived-vascular endothelial growth factor (EG-VEGF) and matrix metalloproteinases (MMPs) are implicated in EVT invasion; however, the high con-centrations found in pregnancy pathologies have not been investigated in non-tumor trophoblasts. The roles of EG-VEGF, prokineticin receptors (PROKR1/2), MMP-2, and MMP-9 in EVT invasion during spiral artery remodeling were evaluated using human EVT from HTR-8/SVneo cell lines. The expression of MMP-2, MMP-9, and mitogen-activated protein kinase (MAPK), and Akt pathways in HTR-8/SVneo cells treated with recom-binant EG-VEGF alongside anti-PROKR1 and/or anti-PROKR2 antibodies was evaluated using quantitative reverse transcription-PCR and western blotting. Wound-healing and cell invasion assays were performed to assess the migration and invasion of these treated cells. Interestingly, 20 nM EG-VEGF activated ERK1/2 sig-naling and upregulated MMP-2 and MMP-9. This effect was suppressed by anti-PROKR2 antibody via ERK1/2 downregulation. Anti-PROKR2 antibody inhibited the migration and invasion of EG-VEGF-stimulated HTR-8/SVneo cells. Elevated concentrations of EG-VEGF enhance EVT invasion in a human trophoblast cell line by upregulating MMP-2 and MMP-9 via PROKR2. These new insights into the regulation of epithelial cell invasion may help in developing therapeutic interventions for placental-related diseases during pregnancy.
キーワード	endocrine gland-derived vascular endothelial growth factor prokineticin extravillous trophoblast matrix metalloproteinase obstetric diseases
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-12
巻	75巻
号	6号
出版者	Okayama University Medical School
開始ページ	677
終了ページ	684
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34955534
Web of Science KeyUT	000735297900002
NAID	120007180286

Multiple Roles of Histidine-Rich Glycoprotein in Vascular Homeostasis and Angiogenesis

JaLCDOI	10.18926/AMO/62805
フルテキストURL	75_6_671.pdf
著者	Gao, Shangze\| Nishibori, Masahiro\|
抄録	Histidine-rich glycoprotein (HRG) is a 75 kDa plasma protein that is synthesized in the liver of many verte-brates and present in their plasma at relatively high concentrations of 100-150 μg/mL. HRG is an abundant and well-characterized protein having a multidomain structure that enable it to interact with many ligands, func-tion as an adaptor molecule, and participate in numerous physiological and pathological processes. As a plasma protein, HRG has been reported to regulate vascular biology, including coagulation, fibrinolysis and angiogenesis, through its binding with several ligands (heparin, FXII, fibrinogen, thrombospondin, and plas-minogen) and interaction with many types of cells (endothelial cells, erythrocytes, neutrophils and platelets). This review aims to summarize the roles of HRG in maintaining vascular homeostasis and regulating angiogen-esis in various pathological conditions.
キーワード	histidine-rich glycoprotein vascular biology coagulation angiogenesis
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2021-12
巻	75巻
号	6号
出版者	Okayama University Medical School
開始ページ	671
終了ページ	675
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34955533
Web of Science KeyUT	000735297900001
NAID	120007180287

Effectiveness of Create ML in microscopy image classifications: a simple and inexpensive deep learning pipeline for non-data scientists

フルテキストURL	fulltext20211026-3.pdf Supplementary_Information_of_Nagaki_Rev.pdf
著者	Nagaki, Kiyotaka\| Furuta, Tomoyuki\| Yamaji, Naoki\| Kuniyoshi, Daichi\| Ishihara, Megumi\| Kishima, Yuji\| Murata, Minoru\| Hoshino, Atsushi\| Takatsuka, Hirotomo\|
キーワード	Machine learning deep learning mitotic cell chromosome tetrad microscope
備考	This is an Accepted Manuscript of an article published by Springer. This fulltext is available in Oct. 2022.\|
発行日	2021-10-14
出版物タイトル	Chromosome Research
巻	29巻
号	3-4号
出版者	Springer Science and Business Media LLC
開始ページ	361
終了ページ	371
ISSN	0967-3849
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s), under exclusive licence to Springer Nature B.V. 2021
論文のバージョン	author
DOI	10.1007/s10577-021-09676-z

Chronic exposure to FGF2 converts iPSCs into cancer stem cells with an enhanced integrin/focal adhesion/PI3K/AKT axis

フルテキストURL	fulltext20211026-1.pdf Supplementary Figures.docx Supplementary Table S1.docx Supplementary Table S2.xlsx Supplementary Table S3.docx Supplementary Table S4.docx Supplementary Table S5.xls Supplementary Table S6.docx
著者	Sheta, Mona\| Hassan, Ghmkin\| Afify, Said M.\| Monzur, Sadia\| Kumon, Kazuki\| Abu Quora, Hagar A.\| Farahat, Mahmoud\| Zahra, Maram H.\| Fu, Xiaoying\| Seno, Akimasa\| Seno, Masaharu\|
キーワード	Cancer initiation Cancer stem cells iPSCs FGF2 Chronic inflammation
備考	©2021 Elsevier BV. This manuscript version is made available under the CC-BY-NC-ND 4.0 License.http://creativecommons.org/licenses/by-nc-nd/4.0/.This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.canlet.2021.08.026] .\|
発行日	2021-11
出版物タイトル	Cancer Letters
巻	521巻
号	28号
出版者	Elsevier BV
開始ページ	142
終了ページ	154
ISSN	0304-3835
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 Elsevier B.V.
論文のバージョン	author
PubMed ID	34455015
DOI	10.1016/j.canlet.2021.08.026
Web of Science KeyUT	000704341600001
関連URL	isVersionOf https://doi.org/10.1016/j.canlet.2021.08.026

NB-LRR-encoding genes conferring susceptibility to organophosphate pesticides in sorghum

フルテキストURL	fulltext.pdf
著者	Jing, Zihuan\| Wacera, Fiona W.\| Takami, Tsuneaki\| Takanashi, Hideki\| Fukada, Fumi\| Kawano, Yoji\| Kajiya-Kanegae, Hiromi\| Iwata, Hiroyoshi\| Tsutsumi, Nobuhiro\| Sakamoto, Wataru\|
発行日	2021-10-06
出版物タイトル	Scientific Reports
巻	11巻
号	1号
出版者	Nature Portfolio
開始ページ	19828
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2021
論文のバージョン	publisher
PubMed ID	34615901
DOI	10.1038/s41598-021-98908-7
Web of Science KeyUT	000706380800049
関連URL	isVersionOf https://doi.org/10.1038/s41598-021-98908-7

Outer membrane vesicles of Porphyromonas gingivalis: Novel communication tool and strategy

フルテキストURL	fulltext.pdf
著者	Okamura, Hirohiko\| Hirota, Katsuhiko\| Yoshida, Kaya\| Weng, Yao\| He, Yuhan\| Shiotsu, Noriko\| Ikegame, Mika\| Uchida-Fukuhara, Yoko\| Tanai, Airi\| Guo, Jiajie\|
キーワード	Extracellular vesicles Outer membrane vesicles Porphyromonas gingivalis Host cell interaction In vivo imaging
発行日	2021-11
出版物タイトル	Japanese Dental Science Review
巻	57巻
出版者	Elsevier Ltd.
開始ページ	138
終了ページ	146
ISSN	1882-7616
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 The Authors.
論文のバージョン	publisher
PubMed ID	34484474
DOI	10.1016/j.jdsr.2021.07.003
Web of Science KeyUT	000704811500018
関連URL	isVersionOf https://doi.org/10.1016/j.jdsr.2021.07.003

Nodal Peripheral T-cell Lymphoma with T Follicular Helper Phenotype Presenting as Chorea During Treatment: A Case Report and Literature Review

フルテキストURL	fulltext.pdf
著者	Kitamura, Wataru\| Ennishi, Daisuke\| Yukawa, Ryoya\| Sasaki, Ryo\| Yoshida, Chikamasa\| Takasuka, Hiroki\| Fujiwara, Hideaki\| Asada, Noboru\| Nishimori, Hisakazu\| Fujii, Keiko\| Fujii, Nobuharu\| Matsuoka, Ken-Ichi\| Abe, Koji\| Yoshino, Tadashi\| Maeda, Yoshinobu\|
キーワード	peripheral T-cell lymphoma chorea single photon-emission computed tomography
発行日	2021-10-01
出版物タイトル	Internal Medicine
巻	60巻
号	19号
出版者	The Japanese Society of Internal Medicine
開始ページ	3155
終了ページ	3160
ISSN	0918-2918
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 The Japanese Society of Internal Medicine
論文のバージョン	publisher
PubMed ID	33814503
DOI	10.2169/internalmedicine.7180-21
Web of Science KeyUT	000706487700015
関連URL	isVersionOf https://doi.org/10.2169/internalmedicine.7180-21

Added Diagnostic Value of Cerebrospinal Fluid Carcinoembryonic Antigen in a Patient with Leptomeningeal Carcinomatosis as the Initial Manifestation of Gastric Cancer

JaLCDOI	10.18926/AMO/62781
フルテキストURL	75_5_659.pdf
著者	Ino, Riku\| Sada, Ken-ei \| Miyauchi, Atsushi\| Hashimoto, Daisuke\| Nojima, Shigeru\| Yamanaka, Shingo\| Kawamura, Masafumi\|
抄録	A 77-year-old woman with no history of malignancy presented with anorexia and bilateral lower extremity weakness. Her consciousness level worsened daily, so we performed a lumbar puncture. Cerebrospinal fluid (CSF) analysis indicated meningitis, but three rounds of CSF cytology showed no malignant cells. The patient’s carcinoembryonic antigen (CEA) level was highly elevated in CSF, but normal in serum. Through gadolinium-enhanced brain/spinal magnetic resonance imaging and gastrointestinal endoscopy, she was diagnosed with leptomeningeal carcinomatosis (LC) from gastric cancer. CEA level in CSF facilitated the diagnosis of LC from gastric cancer because there were no malignant cells on CSF cytology.
キーワード	leptomeningeal carcinomatosis gastric cancer carcinoembryonic antigen cerebrospinal fluid cytology
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2021-10
巻	75巻
号	5号
出版者	Okayama University Medical School
開始ページ	659
終了ページ	661
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34703051
Web of Science KeyUT	000711568400006
NAID	120007166666

Histologic Transformation from Follicular Lymphoma to Diffuse Large B-cell Lymphoma Detected during Colonoscopy

JaLCDOI	10.18926/AMO/62775
フルテキストURL	75_5_625.pdf
著者	Iwamuro, Masaya\| Yamasaki, Yasushi\| Tanaka, Takehiro\| Asada, Noboru\| Matsuoka, Ken-ichi\| Hiraoka, Sakiko\| Kawahara, Yoshiro\| Okada, Hiroyuki\|
抄録	A 77-year-old Japanese woman who had been treated for follicular lymphoma for 8 years developed abdominal pain and intra-abdominal lymphadenopathies. Colonoscopy revealed an elevated lesion in the rectum, which presented as two humps with erosions. A diagnosis of histologic transformation of follicular lymphoma to diffuse large B-cell lymphoma was made by endoscopic biopsy. This case underscores the importance of endoscopy examinations and biopsy of newly emerged gastrointestinal lesions for the prompt diagnosis of histologic transformation, since salvage chemotherapy must be initiated quickly in such cases.
キーワード	colorectal lymphoma follicular lymphoma diffuse large B-cell lymphoma histologic transformation
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2021-10
巻	75巻
号	5号
出版者	Okayama University Medical School
開始ページ	625
終了ページ	629
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34703045
Web of Science KeyUT	000711561300001
NAID	120007166675

Glial Cells as Possible Targets of Neuroprotection through Neurotrophic and Antioxidative Molecules in the Central and Enteric Nervous Systems in Parkinson’s Disease

JaLCDOI	10.18926/AMO/62767
フルテキストURL	75_5_549.pdf
著者	Isooka, Nami\| Miyazaki, Ikuko\| Asanuma, Masato\|
抄録	Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide. The loss of nigrostriatal dopaminergic neurons produces its characteristic motor symptoms, but PD patients also have non-motor symptoms such as constipation and orthostatic hypotension. The pathological hallmark of PD is the presence of α-synuclein-containing Lewy bodies and neurites in the brain. However, the PD pathology is observed in not only the central nervous system (CNS) but also in parts of the peripheral nervous system such as the enteric nervous system (ENS). Since constipation is a typical prodromal non-motor symptom in PD, often preceding motor symptoms by 10-20 years, it has been hypothesized that PD pathology propagates from the ENS to the CNS via the vagal nerve. Discovery of pharmacological and other methods to halt this progression of neurodegeneration in PD has the potential to improve millions of lives. Astrocytes protect neurons in the CNS by secretion of neurotrophic and antioxidative factors. Similarly, astrocyte-like enteric glial cells (EGCs) are known to secrete neuroprotective factors in the ENS. In this article, we summarize the neuroprotective function of astrocytes and EGCs and discuss therapeutic strategies for the prevention of neurodegeneration in PD targeting neurotrophic and antioxidative molecules in glial cells.
キーワード	Parkinson’s disease astrocyte enteric glial cell neurotrophic factor antioxidative molecule
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2021-10
巻	75巻
号	5号
出版者	Okayama University Medical School
開始ページ	549
終了ページ	556
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34703037
Web of Science KeyUT	000711561600001
NAID	120007166678