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フルテキストURL K003017.pdf
著者 藤田 洋史|
発行日 2005-09-30
資料タイプ 学位論文
学位授与番号 甲第3017号
学位授与年月日 2005-09-30
学位・専攻分野 博士(医学)
授与大学 岡山大学
言語 英語
フルテキストURL fulltext.pdf
著者 Jinnai, Seihou| Murayama, Kasumi| Nagai, Keisuke| Mineshita, Megumi| Kato, Kosaku| Muraoka, Azusa| Yamakata, Akira| Saeki, Akinori| Kobori, Yasuhiro| Ie, Yutaka|
発行日 2022-08-09
出版物タイトル Journal of Materials Chemistry A
10巻
37号
出版者 Royal Society of Chemistry (RSC)
開始ページ 20035
終了ページ 20047
ISSN 2050-7488
NCID AA12603290
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Royal Society of Chemistry 2022
論文のバージョン publisher
DOI 10.1039/d2ta02604j
Web of Science KeyUT 000837730900001
関連URL isVersionOf https://doi.org/10.1039/d2ta02604j
フルテキストURL fulltext.pdf
著者 Inoue, Shin‐ichiro| Hayashi, Maki| Huang, Sheng| Yokosho, Kengo| Gotoh, Eiji| Ikematsu, Shuka| Okumura, Masaki| Suzuki, Takamasa| Kamura, Takumi| Kinoshita, Toshinori| Ma, Jian Feng|
キーワード ACDP CNNM Arabidopsis thaliana magnesium transport plant growth stomatal opening
発行日 2022-08-17
出版物タイトル New Phytologist
236巻
3号
出版者 Wiley
開始ページ 864
終了ページ 877
ISSN 0028-646X
NCID AA00755407
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 The Authors
論文のバージョン publisher
PubMed ID 35976788
DOI 10.1111/nph.18410
Web of Science KeyUT 000841377100001
関連URL isVersionOf https://doi.org/10.1111/nph.18410
フルテキストURL O004077.pdf
著者 馬場 雅子|
発行日 2005-12-31
資料タイプ 学位論文
学位授与番号 乙第4077号
学位授与年月日 2005-12-31
学位・専攻分野 博士(医学)
授与大学 岡山大学
言語 英語
フルテキストURL K003052.pdf
著者 信久 徹治|
発行日 2005-12-31
資料タイプ 学位論文
学位授与番号 甲第3052号
学位授与年月日 2005-12-31
学位・専攻分野 博士(医学)
授与大学 岡山大学
言語 英語
フルテキストURL fulltext20230828-02.pdf
著者 Ono, Ryota| Saeki, Nozomu| Kojima, Keiichi| Moriya, Hisao| Sudo, Yuki|
キーワード UVA Saccharomyces cerevisiae Iodide Growth inhibition Suppressive molecule
備考 © 2023 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Oct. 2024.|
発行日 2023-10-15
出版物タイトル Biochemical and Biophysical Research Communications
677巻
出版者 Elsevier BV
開始ページ 1
終了ページ 5
ISSN 0006-291X
NCID AA00564395
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2023 Elsevier Inc.
論文のバージョン author
PubMed ID 37523893
DOI 10.1016/j.bbrc.2023.07.048
Web of Science KeyUT 001047346900001
関連URL isVersionOf https://doi.org/10.1016/j.bbrc.2023.07.048
フルテキストURL fulltext.pdf
著者 Akagi, Satoshi| Nakamura, Kazufumi| Kondo, Megumi| Hirohata, Satoshi| Udono, Heiichiro| Nishida, Mikako| Saito, Yukihiro| Yoshida, Masashi| Miyoshi, Toru| Ito, Hiroshi|
キーワード glycolysis mitochondrial respiration pulmonary arterial hypertension pulmonary artery smooth muscle cells Seahorse technology hypoxia ATP production
発行日 2023-07-31
出版物タイトル Journal of Clinical Medicine
12巻
15号
出版者 MDPI
開始ページ 5028
ISSN 2077-0383
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2023 by the authors.
論文のバージョン publisher
PubMed ID 37568430
DOI 10.3390/jcm12155028
Web of Science KeyUT 001045690800001
関連URL isVersionOf https://doi.org/10.3390/jcm12155028
JaLCDOI 10.18926/AMO/65757
フルテキストURL 77_4_439.pdf
著者 Shiwaku, Takahiro| Ishida, Hisashi| Tatebe, Yasuhisa| Tamefusa, Kosuke| Ochi, Motoharu| Fujiwara, Kaori| Kubo, Toshihide| Nakata, Eiji| Washio, Kana| Tsukahara, Hirokazu|
抄録 A three-year-old boy with Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia (Ph+ALL) presented with an osteolytic lesion in his right upper arm. Tyrosine kinase inhibitors (TKIs) such as imatinib and dasatinib are an essential component throughout the course of treatment for Ph+ALL. However, TKIs are reported to affect the bone metabolism. In the treatment course of the current patient, the osteolytic lesion quickly improved despite the continuous use of TKIs, even during the concomitant use of corticosteroids. This suggests that TKIs can be safely given with concomitant corticosteroids to children with Ph+ALL, even when osteolytic lesions are present.
キーワード acute lymphoblastic leukemia children tyrosine kinase inhibitor osteolysis
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2023-08
77巻
4号
出版者 Okayama University Medical School
開始ページ 439
終了ページ 442
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 37635146
Web of Science KeyUT 001088434900002
JaLCDOI 10.18926/AMO/65752
フルテキストURL 77_4_415.pdf
著者 Jelcic, Dzenis| Puzovic, Velibor| Benzon, Benjamin| Palada, Ivan| Jerković, Jelena| Vulic, Marko|
抄録 The aim of our study was to determine whether the immunohistochemical expression of placental vitamin D receptors is altered in pregnancies complicated by preeclampsia. Vitamin D receptor expression was immunohistochemically analysed in the placentas of three groups: a control group, and early- and late-onset preeclampsia groups. Total immunohistochemical intensity staining of placentas showed that the control group had a median vitamin D receptor (VDR) expression significantly higher than the placentas of mothers with early- and late-onset preeclampsia. There was no difference among the three groups in a semiquantitative analysis of VDR staining of the stroma only. Vitamin D receptors showed lower median expression in preeclampsia-affected pregnancies, especially early-onset preeclampsia. Therefore, Vitamin D receptor expression may be an important marker for normal placentation and preeclampsia onset.
キーワード vitamin D receptor immunohistochemistry early and late-onset preeclampsia
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2023-08
77巻
4号
出版者 Okayama University Medical School
開始ページ 415
終了ページ 422
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 37635142
Web of Science KeyUT 001163659800006
JaLCDOI 10.18926/AMO/65750
フルテキストURL 77_4_395.pdf
著者 Pavlovic, Marko| Babic, Dragan| Rastovic, Pejana| Arapovic, Jurica| Martinac, Marko| Jakovac, Sanja| Barbaric, Romana|
抄録 We investigated the relationship between serum tumor necrosis factor-alpha (TNF-α) levels and psychopathological symptoms, clinical and socio-demographic characteristics and antipsychotic therapy in individuals with schizophrenia. TNF-α levels were measured in 90 patients with schizophrenia and 90 healthy controls matched by age, gender, smoking status, and body mass index. The Positive and Negative Syndrome Scale (PANSS) was used to assess the severity of psychopathology in patients. No significant differences in TNF-α levels were detected between the patients and controls (p=0.736). TNF-α levels were not correlated with total, positive, negative, general, or composite PANSS scores (all p>0.05). A significant negative correlation was observed between TNF-α levels and the PANSS cognitive factor (ρ=−0.222, p=0.035). A hierarchical regression analysis identified the cognitive factor as a significant predictor of the TNF-α level (beta=−0.258, t=−2.257, p=0.027). There were no significant differences in TNF-α levels among patients treated with different types of antipsychotics (p=0.596). TNF-α levels correlated positively with the age of onset (ρ=0.233, p=0.027) and negatively with illness duration (ρ=−0.247, p=0.019) and antipsychotic treatment duration (ρ=−0.256, p=0.015). These results indicate that TNF-α may be involved in cognitive impairment in schizophrenia, and would be a potential clinical-state marker in schizophrenia.
キーワード tumor necrosis factor-alpha schizophrenia psychopathology immune system
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2023-08
77巻
4号
出版者 Okayama University Medical School
開始ページ 395
終了ページ 405
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 37635140
Web of Science KeyUT 001163659800010
JaLCDOI 10.18926/AMO/65748
フルテキストURL 77_4_377.pdf
著者 Morimoto, Kosaku| Takeuchi, Yasuto| Takaki, Akinobu| Wada, Nozomu| Oyama, Atsushi| Adachi, Takuya| Onishi, Hideki| Shiraha, Hidenori| Okada, Hiroyuki|
抄録 Liver fibrosis is an important phenomenon in non-alcoholic fatty liver disease (NAFLD) progression. Standard markers reflecting liver fibrosis, including the FIB-4 index, increase with age. This study aimed to identify fibrosis progression-related markers that are diagnostically beneficial even in aged individuals. Serum levels of pro- and anti-inflammatory cytokines were measured by multiple enzyme-linked immunosorbent assay. Two standard NAFLD or fibrosis progression-related markers — the FIB-4 index and APRI score — were analyzed along with cytokine levels to define the best approach to discriminate advanced fibrosis. Ninety-eight NAFLD patients were enrolled: 59 and 39 patients with fibrosis stages 1-2 and 3-4 respectively. In addition to the FIB-4 index and APRI score, the following factors showed significant differences between stages 1-2 and stages 3-4 in a multivariate analysis: platelet counts, IP-10, and RANTES. The fibrosis stage, FIB-4, APRI, PDGF-BB, and RANTES were related to the prognosis. In aged patients, IP-10, GM-CSF, and RANTES differed between stages 1-2 and stages 3-4. FIB-4 and APRI were beneficial for their correlation with fibrosis. However, to stratify either young or elderly advanced fibrosis patients, and to identify patients likely to have a bad outcome, RANTES was the best marker.
キーワード NAFLD NASH liver fibrosis chemokine FIB-4
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2023-08
77巻
4号
出版者 Okayama University Medical School
開始ページ 377
終了ページ 385
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 37635138
Web of Science KeyUT 001163659800009
JaLCDOI 10.18926/AMO/65745
フルテキストURL 77_4_365.pdf
著者 Moldovan, Elena| Bănescu, Claudia| Cucerea, Manuela| Moldovan, Valeriu| Gozar, Liliana| Pușcașiu, Lucian|
抄録 Congenital heart disease is the most common malformative pathology in newborns, with a worldwide incidence at 0.4-5%. We investigated the possible relationship between variations in nucleotide sequences and specific cardiac malformations in the GATA-binding factor 4 (GATA4) exon 1 region by using Sanger sequencing. Forty-four newborns from a third-level neonatal intensive care unit who were diagnosed with nonsyndromic, ductal-dependent congenital heart disease (i.e., transposition of the great arteries or ductal-dependent coarctation of the aorta) were enrolled. Their DNA was extracted using commercial methods and tested using the multiplex ligation-dependent probe amplification (MLPA) technique. The Sanger sequencing for GATA4 exon 1 in the newborns’ DNA identified rs61277615, rs73203482, and rs35813172 variants not reported in the ClinVar archive of human variations in newborns previously diagnosed with transposition of the great arteries (n=5) and coarctation of the aorta (n=1). The identification of these novel variants in newborns with transposition of the great arteries or ductal-dependent coarctation of the aorta may be the first step in determining the variants’ contribution to the occurrence of congenital heart disease. However, these results may be inconclusive, since the observed variants within GATA4 gene were not previously reported.
キーワード transposition of the great arteries ductal-dependent coarctation of the aorta GATA4 MLPA Sanger sequencing
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2023-08
77巻
4号
出版者 Okayama University Medical School
開始ページ 365
終了ページ 370
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 37635136
Web of Science KeyUT 001163659800008
フルテキストURL fulltext.pdf
著者 Sukegawa, Shintaro| Ono, Sawako| Tanaka, Futa| Inoue, Yuta| Hara, Takeshi| Yoshii, Kazumasa| Nakano, Keisuke| Takabatake, Kiyofumi| Kawai, Hotaka| Katsumitsu, Shimada| Nakai, Fumi| Nakai, Yasuhiro| Miyazaki, Ryo| Murakami, Satoshi| Nagatsuka, Hitoshi| Miyake, Minoru|
備考 The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-38343-y|
発行日 2023-07-19
出版物タイトル Scientific Reports
13巻
1号
出版者 Nature Portfolio
開始ページ 11676
ISSN 2045-2322
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2023
論文のバージョン publisher
PubMed ID 37468501
DOI 10.1038/s41598-023-38343-y
Web of Science KeyUT 001033545700013
関連URL isVersionOf https://doi.org/10.1038/s41598-023-38343-y
フルテキストURL fulltext.pdf
著者 Chen, Mengxi| Tanaka, Takehiro| Igawa, Takuro| Han, Yanyan| Peng, Fangli| Jin, Zaishun| Yoshino, Tadashi|
キーワード PDX1 PTF1A SALL4 Ectopic pancreas Gastro-duodenum Jejunum
発行日 2023-07
出版物タイトル Heliyon
9巻
7号
出版者 Cell Press
開始ページ e18241
ISSN 2405-8440
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2023 The Authors.
論文のバージョン publisher
PubMed ID 37519669
DOI 10.1016/j.heliyon.2023.e18241
Web of Science KeyUT 001043928200001
関連URL isVersionOf https://doi.org/10.1016/j.heliyon.2023.e18241
JaLCDOI 10.18926/AMO/65741
フルテキストURL 77_4_359.pdf
著者 Koshida, Tomohiro| Maruta, Toyoaki| Tanaka, Nobuhiko| Hidaka, Kotaro| Kurogi, Mio| Nemoto, Takayuki| Yanagita, Toshihiko| Takeya, Ryu| Tsuneyoshi, Isao|
抄録 Pulsed radiofrequency (PRF) is a safe method of treating neuropathic pain by generating intermittent electric fields at the needle tip. Resiniferatoxin (RTX) is an ultrapotent agonist of transient receptor potential vanilloid subtype-1 (TRPV1) receptors. We investigated the mechanism of PRF using a rat model of RTX-induced neuropathic pain. After administering RTX intraperitoneally, PRF was applied to the right sciatic nerve. We observed the changes in TRPV1, calcitonin gene-related peptide (CGRP), and brain-derived neurotrophic factor (BDNF) in the dorsal root ganglia by western blotting. Expressions of TRPV1 and CGRP were significantly lower in the contralateral (RTX-treated, PRF-untreated) tissue than in control rats (p<0.0001 and p<0.0001, respectively) and the ipsilateral tissues (p<0.0001 and p<0.0001, respectively). BDNF levels were significantly higher in the contralateral tissues than in the control rats (p<0.0001) and the ipsilateral tissues (p<0.0001). These results suggest that, while TRPV1 and CGRP are decreased by RTX-induced neuronal damage, increased BDNF levels result in pain development. PRF may promote recovery from neuronal damage with concomitant restoration of TRPV1 and CGRP, and exert its analgesic effect by reversing BDNF increase. Further research is required to understand the role of TRPV1 and CGRP restoration in improving mechanical allodynia.
キーワード pulsed radiofrequency resiniferatoxin transient receptor potential vanilloid subtype-1 (TRPV1) calcitonin gene-related peptide (CGRP) brain-derived neurotrophic factor (BDNF)
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2023-08
77巻
4号
出版者 Okayama University Medical School
開始ページ 359
終了ページ 364
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 37635135
Web of Science KeyUT 001163659800011
JaLCDOI 10.18926/AMO/65740
フルテキストURL 77_4_347.pdf
著者 Iwamuro, Masaya| Kondo, Takumi| Ennishi, Daisuke| Fujii, Nobuharu| Matsuoka, Ken-ichi| Takahashi, Takahide| Hirabata, Araki| Tanaka, Takehiro| Otsuka, Fumio| Maeda, Yoshinobu| Okada, Hiroyuki|
抄録 The feasibility of lymphocyte isolation and flow cytometry using a single endoscopic biopsy specimen from the gastrointestinal tract of patients who have undergone hematopoietic stem cell transplantation has not been investigated. We acquired 51 endoscopic biopsy specimens from the gastrointestinal tract of 35 patients. We divided the flow cytometry samples into two groups: group A, successful lymphocyte isolation (n=24), and group B, incomplete isolation (n=27). We compared the backgrounds of the samples between the groups to reveal crucial elements in the successful isolation of lymphocytes residing in the gastrointestinal tract. Comparison between the groups revealed lymphocyte isolation success rates differed between biopsy sites. Isolation was most successful in samples from the duodenum (8/9, 88.9%), followed by the ileum (4/8, 50.0%), large intestine (4/11, 36.4%), and stomach (8/23, 34.8%). Tacrolimus was used more frequently in group B (92.6%) than in group A (62.5%) (p=0.015). Logistic regression analysis revealed that isolation from the duodenum or ileum was a significant factor for successful isolation, while tacrolimus use was not statistically significant. In conclusion, the duodenum and ileum are more suitable sites than the stomach and colorectum for acquiring samples for flow cytometry.
キーワード flow cytometry stem cell transplantation transplantation-associated microangiopathy
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2023-08
77巻
4号
出版者 Okayama University Medical School
開始ページ 347
終了ページ 357
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 37635134
Web of Science KeyUT 001163659800002
JaLCDOI 10.18926/AMO/65739
フルテキストURL 77_4_341.pdf
著者 Otsuka, Motoyuki|
抄録 Hepatitis B virus is a pathogenic virus that infects 300 million people worldwide and causes chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Hepatitis B virus encodes four proteins. Among them, the HBx protein plays a central role in the HBV pathogenesis. Because the HBx protein is considered to play a central role in the induction of viral replication and hepatocarcinogenesis, the regulation of its function could be a key factor in the development of new interventions against hepatitis B. In this review, HBx protein-related viral replication and hepatocarcinogenesis mechanisms are described, with a focus on the recently reported viral replication mechanisms related to degradation of the Smc5/6 protein complex. We also discuss our recent discovery of a compound that inhibits HBx protein-induced degradation of the Smc5/6 protein complex, and that exerts inhibitory effects on both viral replication and hepatocarcinogenesis. Finally, prospects for future research on the HBx protein are described.
キーワード HBx Smc5/6 DDB1 nitazoxianide DNA repair
Amo Type Review
出版物タイトル Acta Medica Okayama
発行日 2023-08
77巻
4号
出版者 Okayama University Medical School
開始ページ 341
終了ページ 345
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 37635133
Web of Science KeyUT 001163659800007
フルテキストURL fulltext.pdf
著者 Hirayama, Takashi| Mochida, Keiichi|
キーワード Biosensor Biostimulant Breeding Mass spectrometry Phytohormone
発行日 2022-05-18
出版物タイトル Plant and Cell Physiology
63巻
12号
出版者 Oxford University Press (OUP)
開始ページ 1826
終了ページ 1839
ISSN 0032-0781
NCID AA0077511X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2022.
論文のバージョン publisher
PubMed ID 35583356
DOI 10.1093/pcp/pcac067
Web of Science KeyUT 000808427800001
関連URL isVersionOf https://doi.org/10.1093/pcp/pcac067
フルテキストURL fulltext20230817-01.pdf fig20230817-01.pdf suppl_fig20230817-01.pdf suppl_table20230817-01.pdf
著者 Kawase, Katsushige| Kawashima, Shusuke| Nagasaki, Joji| Inozume, Takashi| Tanji, Etsuko| Kawazu, Masahito| Hanazawa, Toyoyuki| Togashi, Yosuke|
備考 This is an Accepted Manuscript of an article published by American Association for Cancer Research.| This fulltext file will be available in Jul. 2024.|
発行日 2023-07-05
出版物タイトル Cancer Immunology Research
11巻
7号
出版者 American Association for Cancer Research (AACR)
開始ページ 895
終了ページ 908
ISSN 2326-6066
NCID AA12626809
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2023 American Association for Cancer Research
論文のバージョン author
PubMed ID 37062030
DOI 10.1158/2326-6066.cir-22-0815
Web of Science KeyUT 001038030200001
関連URL isVersionOf https://doi.org/10.1158/2326-6066.CIR-22-0815
フルテキストURL fulltext.pdf
著者 Tsuchiya, Keisuke| Horikoshi, Kanako| Fujita, Minami| Hirano, Motoharu| Miyamoto, Maho| Yokoo, Hidetomo| Demizu, Yosuke|
キーワード cell-penetrating peptide stapled peptide hydrophobic peptide helical structure plasmid DNA delivery
発行日 2023-07-21
出版物タイトル International Journal of Molecular Sciences
24巻
14号
出版者 MDPI
開始ページ 11768
ISSN 1661-6596
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2023 by the authors.
論文のバージョン publisher
PubMed ID 37511527
DOI 10.3390/ijms241411768
Web of Science KeyUT 001038508200001
関連URL isVersionOf https://doi.org/10.3390/ijms241411768