検索結果 - 岡山大学学術成果リポジトリ

Role of a sensor histidine kinase ChiS of Vibrio cholerae in pathogenesis

フルテキストURL	Int_J_Med_Microbiol_306_8_657.pdf
著者	Chourashi, Rhishita\| Mondal, Moumita\| Sinha, Ritam\| Debnath, Anusuya\| Das, Suman\| Koley, Hemanta\| Sekhar Chatterjeea, Nabendu\|
キーワード	ChiS Mucin Vibrio cholerae Virulence
備考	This is an Accepted Manuscript of an article published by Elsevier GmbH\|
発行日	2016-12
出版物タイトル	International Journal of Medical Microbiology
巻	306巻
号	8号
出版者	ELSEVIER GMBH
開始ページ	657
終了ページ	665
ISSN	14384221
NCID	AA11427330
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	27670078
DOI	10.1016/j.ijmm.2016.09.003
Web of Science KeyUT	000390824600008
関連URL	isVersionf https://doi.org/10.1016/j.ijmm.2016.09.003

マウス視床下部・下垂体・生殖腺系における転写因子Runx3の役割

タイトル（別表記）	Transcription factor Runx3 in the mouse hypothalamo-pituitary-gonadal system
フルテキストURL	poalas_034_002.pdf
著者	高橋純夫\|
抄録	Runx3 is a transcription factor that belongs to the Runx family. Female Runx3 knockout (Runx3−⁄−) mouse was anovulatory and infertile. Ovarian transplantation experiment suggested that lack of ovulation in Runx3−⁄− mice was caused by alteration of gonadotropin secretion in Runx3−⁄− mice. Cyp11a1 mRNA expression was less in Runx3−⁄− mouse ovaries than in wt ones. Hypothalamic Gnrh1 mRNA was increased, and Kiss1 mRNA expression in the anteroventral periventricular nucleus was decreased, but Kisspeptin mRNA in the arcuate nucleus was increased in Runx3-/- mice. Pituitary Fshb mRNA levels were increased in Runx3−⁄− mice. Cholesterol side-chain cleavage enzyme gene (Cyp11a1) expression was decreased in ovaries of Runx3−⁄− mice. These findings suggest that anovulation in Runx3−⁄− mice was partly due to the alterations in hypothalamus-pituitary-ovary system. Runx3 plays a key role in female reproduction through alteration of gonadotropin secretion.
出版物タイトル	岡山実験動物研究会報
発行日	2018-04
巻	34巻
開始ページ	2
終了ページ	4
言語	日本語
論文のバージョン	publisher

Expressions of lipoprotein receptors and cholesterol efflux regulatory proteins during luteolysis in bovine corpus luteum

フルテキストURL	Reprod_Fertil_Dev_29_7_1280.pdf fig.pdf
著者	Horihata, Kei\| Yoshioka, Shin\| Sano, Masahiro\| Yamamoto, Yuki\| Kimura, Koji\| Skarzynski, Dariusz J.\| Okuda, Kiyoshi\|
キーワード	luteal phase ovary progesterone prostaglandin reproduction
備考	This is an Accepted Manuscript of an article published by CSIRO Publishing\|
発行日	2016-05-17
出版物タイトル	Reproduction, Fertility and Development
巻	29巻
号	7号
出版者	CSIRO Publishing
開始ページ	1280
終了ページ	1286
ISSN	10313613
NCID	AA10718189
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン	author
PubMed ID	27185011
DOI	10.1071/RD15538
Web of Science KeyUT	000403550200002
関連URL	https://doi.org/10.1071/RD15538

Endothelin as a local regulating factor in the bovine oviduct

フルテキストURL	Reprod_Fertil_Dev_28_6_673.pdf
著者	Yamamoto, Yuki\| Kohka, Misa\| Kobayashi, Yoshihiko\| Woclawek-Potocka, Izabela\| Okuda, Kiyoshi\|
キーワード	endothelin converting enzyme endothelin receptor epithelial cell ovarian steroids oviductal contraction and relaxation
備考	This is an Accepted Manuscript of an article published by CSIRO Publishing\|
発行日	2014-11
出版物タイトル	Reproduction, Fertility and Development
巻	28巻
号	6号
出版者	CSIRO Publishing
開始ページ	673
終了ページ	681
ISSN	1031-3613
NCID	AA10718189
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン	author
PubMed ID	25370848
DOI	10.1071/RD14076
Web of Science KeyUT	000374546100003
関連URL	isVersionOf https://doi.org/10.1071/RD14076

Presence of vascular endothelial growth factor during the first half of IVM improves the meiotic and developmental competence of porcine oocytes from small follicles

フルテキストURL	Reprod_Fertil_Dev_29_10_1902.pdf
著者	Bui, Tra M. T.\| Nguyễn, Khánh X.\| Karata, Asako\| Ferré, Pilar\| Trần, Minh T.\| Wakai, Takuya\| Funahashi, Hiroaki\|
キーワード	pig
備考	This is an Accepted Manuscript of an article published by CSIRO Publishing\|
発行日	2016-12-12
出版物タイトル	Reproduction, Fertility and Development
巻	29巻
号	10号
出版者	CSIRO Publishing
開始ページ	1902
終了ページ	1909
ISSN	1031-3613
NCID	AA10718189
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン	author
PubMed ID	27938625
DOI	10.1071/RD16321
Web of Science KeyUT	000409376900003
関連URL	https://doi.org/10.1071/RD16321

Histologic Evaluation of Lymphaticovenular Anastomosis Outcomes in the Rat Experimental Model: Comparison of Cases with Patency and Obstruction

フルテキストURL	K0005439_other2.pdf
著者	Onoda, Satoshi\| Kimata, Yoshihiro\| Matsumoto, Kumiko\| Yamada, Kiyoshi\|
備考	学位審査副論文\|
発行日	2016-01
出版物タイトル	Plastic and Reconstructive Surgery
巻	137巻
号	1号
出版者	Lippincott Williams & Wilkins
開始ページ	83e
終了ページ	91e
ISSN	00321052
NCID	AA00775696
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン	author
PubMed ID	26710064
DOI	10.1097/PRS.0000000000001884
Web of Science KeyUT	000367333300001
関連URL	https://doi.org/10.1097/PRS.0000000000001884

遺伝子改変マウスを利用した生体内間葉系幹細胞の階層性の理解

タイトル（別表記）	Dissecting the hierarchy and lineage of mesenchymal stem cells by mouse genetics
フルテキストURL	poalas_033_015_017.pdf
著者	宝田剛志\|
抄録	Determination of stem cell hierarchy/lineage is indispensable for a better understanding and augmentation of many aspects of medical sciences, including the mechanisms of tissue development and maintenance of tissue homeostasis, as well as disease development. It also has implications in the field of tissue regeneration for medical treatments and disease modeling for drug discovery using iPS technology. Mesenchymal stem cells are multipotent stem cell that can differentiate into various type of cells including osteoblasts, adipocytes, myocytes and chondrocytes. Runt-related transcription factor 2 (Runx2) is an essential transcriptional regulator of osteoblast differentiation. Runx2 deficiency in Prx1+-derived cells (Runx2prx1−/− mice) resulted in defective intramembranous ossification. Double-positive cells for Prx1-GFP and stem cell antigen-1 (Sca1) (Prx1+Sca1+ cells) in the calvaria expressed Runx2 at lower levels and were more homogeneous and primitive as compared with Prx1+Sca1− cells. Our results suggest that osteoblast differentiation in vivo may begin at the Prx1+Sca1+ MSC stage with sequential progression to Prx1+Sca1−cells, then Osx+Prx1−Sca1− osteoblast precursors, which eventually form mature α1(I)-collagen+ osteoblasts.
出版物タイトル	岡山実験動物研究会報
発行日	2017-04
巻	33巻
開始ページ	15
終了ページ	17
言語	日本語
論文のバージョン	publisher

Effect of Vandetanib on Lung Tumorigenesis in Transgenic Mice Carrying an Activating Egfr Gene Mutation

JaLCDOI	10.18926/AMO/54499
フルテキストURL	70_4_243.pdf
著者	Osawa, Masahiro\| Ohashi, Kadoaki\| Kubo, Toshio\| Ichihara, Eiki\| Takata, Saburo\| Takigawa, Nagio\| Takata , Minoru\| Tanimoto, Mitsune\| Kiura, Katsuyuki\|
抄録	Vandetanib (ZactimaTM) is a novel, orally available inhibitor of both vascular endothelial growth factor receptor-2 (VEGFR-2) and epidermal growth factor receptor (EGFR) tyrosine kinase. In the present study, a line of transgenic mice with a mouse Egfr gene mutation (delE748-A752) corresponding to a human EGFR mutation (delE746-A750) was established. The transgenic mice developed atypical adenomatous hyperplasia to adenocarcinoma of the lung at around 5 weeks of age and died of lung tumors at approximately 17 weeks of age. In the mice treated with vandetanib (6mg/kg/day), these lung tumors disappeared and the phosphorylations of EGFR and VEGFR-2 were reduced in lung tissues to levels comparable to those of non-transgenic control mice. The median overall survival time of the transgenic mice was 28 weeks in the vandetanib-treated group and 17 weeks in the vehicle-treated group. Vandetanib significantly prolonged the survival of the transgenic mice (log-rank test, p＜0.01); resistance to vandetanib occurred at 20 weeks of age and the animals died from their lung tumors at about 28 weeks of age. These data suggest that vandetanib could suppress the progression of tumors harboring an activating EGFR mutation.
キーワード	vandetanib VEGFR EGFR nonsmall cell lung cancer transgenic mouse
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2016-08
巻	70巻
号	4号
出版者	Okayama University Medical School
開始ページ	243
終了ページ	253
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2016 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	27549668
Web of Science KeyUT	000384748600003

ウシ卵管平滑筋運動を制御する局所因子とその発現制御機構

著者	山本ゆき\|
発行日	2016-02-01
出版物タイトル	岡山大学農学部学術報告
巻	105巻
資料タイプ	紀要論文

ウサギはなぜ糞を食べる？

著者	坂口英\|
発行日	2015-02-01
出版物タイトル	岡山大学農学部学術報告
巻	104巻
資料タイプ	紀要論文

Serum levels of platelet-derived growth factor-BB and vascular endothelial growth factor as prognostic factors for patients with fulminant hepatic failure

著者	Takayama, Hiroki\| Miyake, Yasuhiro\| Nouso, Kazuhiro\| Ikeda, Fusao\| Shiraha, Hidenori\| Takaki, Akinobu\| Kobashi, Haruhiko\| Yamamoto, Kazuhide\|
発行日	2011-01
出版物タイトル	Journal of Gastroenterology and Hepatology
巻	26巻
号	1号
資料タイプ	学術雑誌論文

Hox 遺伝子と聴覚回路の発生

著者	成田裕一\| Kajari Karmakar\| Sébastien Ducret\| Filippo M. Rijli\|
発行日	2014-04
出版物タイトル	岡山実験動物研究会報
巻	30巻
資料タイプ	その他

Effects of Biliverdin Administration on Acute Lung Injury Induced by Hemorrhagic Shock and Resuscitation in Rats

著者	Kosaka, Junko\| Morimatsu, Hiroshi\| Takahashi, Toru\| Shimizu, Hiroko\| Kawanishi, Susumu\| Omori, Emiko\| Endo, Yasumasa\| Tamaki, Naofumi\| Morita, Manabu\| Morita, Kiyoshi\|
発行日	2013-05-07
出版物タイトル	PLoS ONE
巻	8巻
号	5号
資料タイプ	学術雑誌論文

組織形成因子Fgf10

著者	大内淑代\|
発行日	2013-12-02
出版物タイトル	岡山医学会雑誌
巻	125巻
号	3号
資料タイプ	学術雑誌論文

Antiproliferative effect of a novel mTOR inhibitor temsirolimus contributes to the prolonged survival of orthotopic esophageal cancer-bearing mice

著者	Nishikawa, Toshio\| Takaoka, Munenori\| Ohara, Toshiaki\| Tomono, Yasuko\| Hao, Huifang\| Bao, Xiaohong\| Fukazawa, Takuya\| Wang, Zhigang\| Sakurama, Kazufumi\| Fujiwara, Yasuhiro\| Motoki, Takayuki\| Shirakawa, Yasuhiro\| Yamatsuji, Tomoki\| Tanaka, Noriaki\| Fujiwara, Toshiyoshi\| Naomoto, Yoshio\|
発行日	2013-03
出版物タイトル	Cancer Biology & Therapy
巻	14巻
号	3号
資料タイプ	学術雑誌論文

Hemin Treatment Abrogates Monocrotaline-Induced Pulmonary Hypertension

著者	Shimzu, K.\| Takahashi, T.\| Iwasaki, T.\| Shimizu, H.\| Inoue, K.\| Morimatsu, H.\| Omori, E.\| Matsumi, M.\| Akagi, R.\| Morita, K.\|
発行日	2008-11
出版物タイトル	Medicinal Chemistry
巻	4巻
号	6号
資料タイプ	学術雑誌論文

Preventive effects of trehalose on osteoclast differentiation in rat periodontitis model

著者	Endo, Yasumasa\| Tomofuji, Takaaki\| Ekuni, Daisuke\| Azuma, Tetsuji\| Irie, Koichiro\| Kasuyama, Kenta\| Morita, Manabu\|
発行日	2013-01
出版物タイトル	Journal of Clinical Periodontology
巻	40巻
号	1号
資料タイプ	学術雑誌論文

Redox-Active Protein Thioredoxin-1 Administration Ameliorates Influenza A Virus (H1N1)-Induced Acute Lung Injury in Mice

著者	Yashiro, Masato\| Tsukahara, Hirokazu\| Matsukawa, Akihiro\| Yamada, Mutsuko\| Fujii, Yosuke\| Nagaoka, Yoshiharu\| Tsuge, Mitsuru\| Yamashita, Nobuko\| Ito, Toshihiro\| Yamada, Masao\| Masutani, Hiroshi\|
発行日	2013-01
出版物タイトル	Critical Care Medicine
巻	41巻
号	1号
資料タイプ	学術雑誌論文

ニワトリのリンパ球造成と性ステロイドホルモン

著者	近藤康博\|
発行日	2013-02-01
出版物タイトル	岡山大学農学部学術報告
巻	102巻
資料タイプ	紀要論文

Water Extract of Vitis coignetiae Pulliat Leaves Attenuates Oxidative Stress and Inflammation in Progressive NASH Rats

JaLCDOI	10.18926/AMO/48686
フルテキストURL	66_4_317.pdf
著者	Pak, Wing\| Takayama, Fusako\| Hasegawa, Azusa\| Mankura, Mitsumasa\| Egashira, Toru\| Ueki, Keiji\| Nakamoto, Kazuo\| Kawasaki, Hiromu\| Mori, Akitane\|
抄録	This study aimed to investigate the therapeutic effects of the water extract of leaves of Vitis coignetiae Pulliat (VCPL) on nonalcoholic steatohepatitis (NASH) with advanced fibrosis, as our previous study exhibited its preventive effect on NASH. The NASH animal model [PCT/JP2007/52477] was prepared by loading recurrent and intermittent hypoxemia stress to a rat with fatty liver, which resembled the condition occurring in patients with obstructive sleep apnea (OSA) and fatty liver, who have a high incidence of NASH. Intermittent hypoxemia stress is regarded as a condition similar to warm ischemia followed by re-oxygenation, which induces oxidative stress (OS). The daily 100 or 300mg/kg VCPL administrations were performed for 3 weeks perorally beginning at the time of detection of advanced liver fibrosis. The therapeutic efficacy of VCPL on NASH was demonstrated by the reduction of the leakage of hepato-biliary enzymes and the amelioration of liver fibrosis. The OS elevation in NASH rats was measured based on the derivation of reactive oxygen species from liver mitochondrial energy metabolism and on the decrease in plasma SOD-like activity. The aggravation of inflammatory responses was demonstrated by the neutrophil infiltration (elevated myeloperoxidase activity) and the progression of fibrosis in the livers of NASH rats. In addition, the NASH rats without VCPL treatment also exhibited activation of nuclear factor-κB, a key factor in the link between oxidative stress and inflammation. All of these changes were reduced dose-dependently by the VCPL administration. These findings indicate that VCPL may improve hepatic fibrosis or at least suppress the progression of NASH, by breaking the crosstalk between OS and inflammation.
キーワード	non-alcoholic steatohepatitis antioxidative oxidative stress anti-inflammation Vitis coignetiae Pulliat
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2012-08
巻	66巻
号	4号
出版者	Okayama University Medical School
開始ページ	317
終了ページ	327
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	22918204
Web of Science KeyUT	000307918900004