検索結果 146 件
| JaLCDOI | 10.18926/AMO/64113 |
|---|---|
| フルテキストURL | 76_6_635.pdf |
| 著者 | Zhang, Cuicui| Ji, Yanan| Wang, Qin| Ruan, Lianying| |
| 抄録 | To investigate the association between serum miR-338-3p levels and neonatal acute respiratory distress syndrome (ARDS) and its mechanism. The relative miR-338-3p expression in serum was detected by quantitative real-time RT-PCR. Interleukin-1beta (IL-1β), IL-6, and tumor necrosis factor-alpha (TNF-α) levels were detected by ELISAs. A receiver operating characteristic (ROC) curve analysis of serum miR-338-3p evaluated the diagnosis of miR-338-3p in neonatal ARDS. Pearson’s correlation analysis evaluated the correlation between serum miR-338-3p and neonatal ARDS clinical factors. Flow cytometry evaluated apoptosis, and a CCK-8 assay assessed cell viability. A luciferase assay evaluated the miR-338-3p/AKT3 relationship. The miR- 338-3p expression was decreased in neonatal ARDS patients and in lipopolysaccharide (LPS)-treated cells. The ROC curve showed the accuracy of miR-338-3p for evaluating neonatal ARDS patients. The correlation analysis demonstrated that miR-338-3p was related to PRISM-III, PaO2/FiO2, oxygenation index, IL-1β, IL-6, and TNF-α in neonatal ARDS patients. MiR-338-3p overexpression inhibited the secretion of inflammatory components, stifled cell apoptosis, and LPS-induced advanced cell viability. The double-luciferase reporter gene experiment confirmed that miR-338-3p negatively regulates AKT3 mRNA expression. Serum miR-338-3p levels were related to the diagnosis and severity of neonatal ARDS, which may be attributed to its regulatory effect on inflammatory response in ARDS. |
| キーワード | miR-338-3p AKT3 neonatal ARDS inflammation diagnosis |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 635 |
| 終了ページ | 643 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549765 |
| Web of Science KeyUT | 000905195100003 |
| JaLCDOI | 10.18926/AMO/64025 |
|---|---|
| フルテキストURL | 76_5_503.pdf |
| 著者 | Ogawa, Hirohito| Honda, Tomoyuki| |
| 抄録 | Eukaryotic genomes contain numerous copies of endogenous viral elements (EVEs), most of which are considered endogenous retrovirus (ERV) sequences. Over the past decade, non-retroviral endogenous viral elements (nrEVEs) derived from ancient RNA viruses have been discovered. Several functions have been proposed for these elements, including antiviral defense. This review summarizes the current understanding of nrEVEs derived from RNA viruses, particularly endogenous bornavirus-like elements (EBLs) and endogenous filovirus-like elements (EFLs). EBLs are one of the most extensively studied nrEVEs. The EBL derived from bornavirus nucleoprotein (EBLN) is thought to function as a non-coding RNA or protein that regulates host gene expression or inhibits virus propagation. Ebolavirus and marburgvirus, which are filoviruses, induce severe hemorrhagic fever in humans and nonhuman primates. Although the ecology of filoviruses remains unclear, bats are believed to be potential reservoirs. Based on the knowledge from EBLs, it is postulated that EFLs in the bat genome help to maintain the balance between filovirus infection and the bat’s defense system, which may partially explain why bats act as potential reservoirs. Further research into the functions of nrEVEs could reveal novel antiviral systems and inspire novel antiviral approaches. |
| キーワード | EVE nrEVE bornavirus filovirus antiviral |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-10 |
| 巻 | 76巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 503 |
| 終了ページ | 510 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36352796 |
| Web of Science KeyUT | 000884907100002 |
| JaLCDOI | 10.18926/AMO/64024 |
|---|---|
| フルテキストURL | 76_5_489.pdf |
| 著者 | Matsumoto, Yuji| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Date, Isao| |
| 抄録 | Glioblastoma (GBM) is a fatal primary malignant brain tumor in adults. Despite decades of research, the prognosis for GBM patients is still disappointing. One major reason for the intense therapeutic resistance of GBM is inter- and intra-tumor heterogeneity. GBM-intrinsic transcriptional profiling has suggested the presence of at least three subtypes of GBM: the proneural, classic, and mesenchymal subtypes. The mesenchymal subtype is the most aggressive, and patients with the mesenchymal subtype of primary and recurrent tumors tend to have a worse prognosis compared with patients with the other subtypes. Furthermore, GBM can shift from other subtypes to the mesenchymal subtype over the course of disease progression or recurrence. This phenotypic transition is driven by diverse tumor-intrinsic molecular mechanisms or microenvironmental factors. Thus, better understanding of the plastic nature of mesenchymal transition in GBM is pivotal to developing new therapeutic strategies. In this review, we provide a comprehensive overview of the current understanding of the elements involved in the mesenchymal transition of GBM and discuss future perspectives. |
| キーワード | glioma glioblastoma mesenchymal subtype mesenchymal transition heterogeneity |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-10 |
| 巻 | 76巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 489 |
| 終了ページ | 502 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36352795 |
| Web of Science KeyUT | 000884907100001 |
| JaLCDOI | 10.18926/AMO/63889 |
|---|---|
| フルテキストURL | 76_4_373.pdf |
| 著者 | Imafuku, Fuminori| Miyazaki, Ikuko| Sun, Jin| Kamimai, Sunao| Shimizu, Takashi| Toyota, Toshiaki| Okamoto, Yusei| Isooka, Nami| Kikuoka, Ryo| Kitamura, Yoshihisa| Asanuma, Masato| |
| 抄録 | Parkinson’s disease (PD) is a progressive neurodegenerative disease of both the central and peripheral / enteric nervous systems. Oxidative stress and neuroinflammation are associated with the pathogenesis of PD, suggesting that anti-oxidative and anti-inflammatory compounds could be neuroprotective agents for PD. Eucommia ulmoides (EU) is a traditional herbal medicine which exerts neuroprotective effects by anti-inflammatory and anti-oxidative properties. Our previous study showed that treatment with chlorogenic acid, a component of EU, protected against neurodegeneration in the central and enteric nervous systems in a PD model. In this study, we examined the effects of EU extract (EUE) administration on dopaminergic neurodegeneration, glial response and α-synuclein expression in the substantia nigra pars compacta (SNpc), and intestinal enteric neurodegeneration in low-dose rotenone-induced PD model mice. Daily oral administration of EUE ameliorated dopaminergic neurodegeneration and α-synuclein accumulation in the SNpc. EUE treatment inhibited rotenone- induced decreases in the number of total astrocytes and in those expressing the antioxidant molecule metallothionein. EUE also prevented rotenone-induced microglial activation. Furthermore, EUE treatment exerted protective effects against intestinal neuronal loss in the PD model. These results suggest that EU exerts neuroprotective effects in the central and enteric nervous systems of rotenone-induced parkinsonism mice, in part by glial modification. |
| キーワード | Eucommia ulmoides dopamine neuron enteric neuron glia Parkinson’s disease |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 373 |
| 終了ページ | 383 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123151 |
| Web of Science KeyUT | 000882167300003 |
| JaLCDOI | 10.18926/AMO/63719 |
|---|---|
| フルテキストURL | 76_3_255.pdf |
| 著者 | Nakatsuka, Kosuke| Matsuoka, Yoshikazu| Kurita, Masako| Wang, Ruilin| Tsuboi, Chika| Sue, Nobutaka| Kaku, Ryuji| Morimatsu, Hiroshi| |
| 抄録 | Mirror image pain (MIP) is a type of extraterritorial pain that results in contralateral pain or allodynia. Glutamate transporter-1 (GLT-1) is expressed in astrocytes and plays a role in maintaining low glutamate levels in the synaptic cleft. Previous studies have shown that GLT-1 dysfunction induces neuropathic pain. Our previous study revealed bilateral GLT-1 downregulation in the spinal cord of a spared nerve injury (SNI) rat. We hypothesized that spinal GLT-1 is involved in the mechanism of MIP. We also previously demonstrated noradrenergic GLT-1 regulation. Therefore, this study aimed to investigate the effect of an α1 adrenergic antagonist on the development of MIP. Rats were subjected to SNI. Changes in pain behavior and GLT-1 protein levels in the SNI rat spinal cords were then examined by intrathecal administration of the α1 adrenergic antagonist phentolamine, followed by von Frey test and western blotting. SNI resulted in the development of MIP and bilateral downregulation of GLT-1 protein in the rat spinal cord. Intrathecal phentolamine increased contralateral GLT-1 protein levels and partially ameliorated the 50% paw withdrawal threshold in the contralateral hind paw. Spinal GLT-1 upregulation by intrathecal phentolamine ameliorates MIP. GLT-1 plays a role in the development of MIPs. |
| キーワード | alpha adrenergic receptor glutamate transporter-1 mirror image pain neuropathic pain spared nerve injury |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-06 |
| 巻 | 76巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 255 |
| 終了ページ | 263 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35790355 |
| Web of Science KeyUT | 000823568300004 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Satoh, Akira| Kashimoto, Rena| Ohashi, Ayaka| Furukawa, Saya| Yamamoto, Sakiya| Inoue, Takeshi| Hayashi, Toshinori| Agata, Kiyokazu| |
| キーワード | Pde4b Limb regeneration Pleurodels waltl Ambystoma mexicanum Dedifferentiation Reprogramming |
| 発行日 | 2022-04-28 |
| 出版物タイトル | Zoological Letters |
| 巻 | 8巻 |
| 号 | 1号 |
| 出版者 | BMC |
| 開始ページ | 6 |
| ISSN | 2056-306X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2022. |
| 論文のバージョン | publisher |
| PubMed ID | 35484631 |
| DOI | 10.1186/s40851-022-00190-6 |
| Web of Science KeyUT | 000788596700001 |
| 関連URL | isVersionOf https://doi.org/10.1186/s40851-022-00190-6 |
| フルテキストURL | fulltext20220413-1.pdf FeaturedImage20220413-1.pdf figures20220413-1.pdf tables20220413-1.pdf SI20220413-1.pdf |
|---|---|
| 著者 | Takemura-Uchiyama, Iyo| Tsurui, Hiroki| Shimakura, Hidekatsu| Nasukawa, Tadahiro| Imanishi, Ichiro| Uchiyama, Jumpei| Fukuyama, Tomoki| Sakamoto, Shuji| Morisawa, Keiko| Fujimura, Masato| Murakami, Hironobu| Kanamaru, Shuji| Kurokawa, Kenji| Kawamoto, Keiko| Iyori, Keita| Sakaguchi, Masahiro| |
| キーワード | Staphylococcus pseudintermedius atopic dermatitis IgE dogs DM13-domain-containing protein exacerbation factor |
| 備考 | This is a pre-copyedited, author-produced version of an article accepted for publication in [insert journal title] following peer review. The version of record [insert complete citation information here] is available online at: https://doi.org/10.1093/femsle/fnac019| |
| 発行日 | 2022 |
| 出版物タイトル | FEMS Microbiology Letters |
| 巻 | 369巻 |
| 号 | 1号 |
| 出版者 | Oxford University Press (OUP) |
| 開始ページ | fnac019 |
| ISSN | 1574-6968 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2022. Published by Oxford University Press on behalf of FEMS. |
| 論文のバージョン | author |
| PubMed ID | 35191469 |
| DOI | 10.1093/femsle/fnac019 |
| Web of Science KeyUT | 000764887500001 |
| 関連URL | isVersionOf https://doi.org/10.1093/femsle/fnac019 |
| JaLCDOI | 10.18926/AMO/62771 |
|---|---|
| フルテキストURL | 75_5_585.pdf |
| 著者 | Omiya, Hiroki| Takatori, Makoto| Yunoki, Keiji| Morimatsu, Hiroshi| |
| 抄録 | Many patients develop acute kidney injury (AKI) after vascular surgery. In this retrospective observational study, we investigated the risk factors for AKI defined using the Kidney Disease Improving Global Outcomes criteria after total arch replacement (TAR). Additionally, we investigated the influence of temperature manage-ment during cardiopulmonary bypass (CPB) on postoperative renal function by propensity score-matched anal-ysis. We retrospectively analyzed 161 consecutive patients who underwent TAR between 2016 and 2019. Postoperative AKI occurred in 48.7% of the patients. In the multivariate analysis, male sex (odds ratio [OR] 3.95, 95% confidence interval [95%CI] 1.56-8.27, p = 0.002), ACE inhibitors/ARB medication (OR 3.19, 95%CI 1.49-6.82, p = 0.003), preoperative chronic kidney disease (OR 2.47, 95%CI 1.17-5.23, p = 0.02), pro-longed CPB time (OR 2.36, 95%CI 1.05-5.34, p = 0.04), and lower body ischemic time during CPB (OR 2.20, 95%CI 1.05-4.46, p = 0.04) were identified as independent risk factors for AKI. Propensity score-matched anal-ysis showed no significant difference in the risk of AKI following TAR between mild hypothermia or normo-thermia and moderate hypothermia (37.2% vs. 41.9%, p = 0.83). In conclusion, modifiable risk factors for AKI included prolonged CPB time and lower body ischemic time. Temperature management during CPB had no clear effect on outcomes. |
| キーワード | acute kidney injury total arch replacement cardiopulmonary bypass lower body ischemic time |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-10 |
| 巻 | 75巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 585 |
| 終了ページ | 593 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34703041 |
| Web of Science KeyUT | 000711561600005 |
| NAID | 120007166671 |
| JaLCDOI | 10.18926/AMO/62767 |
|---|---|
| フルテキストURL | 75_5_549.pdf |
| 著者 | Isooka, Nami| Miyazaki, Ikuko| Asanuma, Masato| |
| 抄録 | Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide. The loss of nigrostriatal dopaminergic neurons produces its characteristic motor symptoms, but PD patients also have non-motor symptoms such as constipation and orthostatic hypotension. The pathological hallmark of PD is the presence of α-synuclein-containing Lewy bodies and neurites in the brain. However, the PD pathology is observed in not only the central nervous system (CNS) but also in parts of the peripheral nervous system such as the enteric nervous system (ENS). Since constipation is a typical prodromal non-motor symptom in PD, often preceding motor symptoms by 10-20 years, it has been hypothesized that PD pathology propagates from the ENS to the CNS via the vagal nerve. Discovery of pharmacological and other methods to halt this progression of neurodegeneration in PD has the potential to improve millions of lives. Astrocytes protect neurons in the CNS by secretion of neurotrophic and antioxidative factors. Similarly, astrocyte-like enteric glial cells (EGCs) are known to secrete neuroprotective factors in the ENS. In this article, we summarize the neuroprotective function of astrocytes and EGCs and discuss therapeutic strategies for the prevention of neurodegeneration in PD targeting neurotrophic and antioxidative molecules in glial cells. |
| キーワード | Parkinson’s disease astrocyte enteric glial cell neurotrophic factor antioxidative molecule |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-10 |
| 巻 | 75巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 549 |
| 終了ページ | 556 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34703037 |
| Web of Science KeyUT | 000711561600001 |
| NAID | 120007166678 |
| フルテキストURL | fulltext20210512_2.pdf figure20210512_2.pdf Supplemental20210512_2.pdf |
|---|---|
| 著者 | Urmi, Alam Saki| Inaba, Hiroaki| Nomura, Ryota| Yoshida, Shoko| Ohara, Naoya| Asai, Fumitoshi| Nakano, Kazuhiko| Matsumoto‐Nakano, Michiyo| |
| キーワード | coaggregation haemagglutination P. gulae protease protein degradation |
| 備考 | This is an Accepted Manuscript of an article published by Wiley. This is the peer reviewed version of the following article: [Urmi, AS, Inaba, H, Nomura, R, et al. Roles of Porphyromonas gulae proteases in bacterial and host cell biology. Cellular Microbiology. 2021; 23:e13312. https://doi.org/10.1111/cmi.13312], which has been published in final form at [https://doi.org/10.1111/cmi.13312]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| |
| 発行日 | 2021-5-3 |
| 出版物タイトル | Cellular Microbiology |
| 出版者 | Wiley |
| 開始ページ | e13312 |
| ISSN | 1462-5814 |
| NCID | AA1136678X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| PubMed ID | 33486854 |
| DOI | 10.1111/cmi.13312 |
| Web of Science KeyUT | 000646670900001 |
| 関連URL | isVersionOf https://doi.org/10.1111/cmi.13312 |
| JaLCDOI | 10.18926/ATM/61436 |
|---|---|
| フルテキストURL | 75_1_63.pdf |
| 著者 | Tada, Katsuhiko| Miyagi, Yasunari| Nakamura, Kazue| Yorozu, Moe| Fukushima, Emi| Kumazawa, Kazumasa| Nakamura, Makoto| Kageyama, Misao| |
| 抄録 | We used a differential equation to identify the biological relationship between the maternal prepregnancy body mass index (BMI) and lactation on postpartum day 4 in Japanese women with neonatal separation. This retro-spective observational study included 252 mothers (135 primiparas, 117 multiparas) whose singleton neonates were admitted to a neonatal ICU. We formulated hypotheses based on breast anatomy to analyze the relation-ship between the expressed milk obtained on postpartum day 4 and the maternal prepregnancy BMI with the following differential equation: y’(x) = k y(x)/x, where k is the constant, x is the prepregnancy BMI, and y is the expressed milk volume. The formula was then obtained as y(x) = axk, where a is the constant. The Akaike information criterion (AIC) was used to estimate the regression equation with the maximum likelihood for primiparas and multiparas. The best criteria for BMI determined by the AIC were 20.89 kg/m2 in primiparas and 20.19 kg/m2 in multiparas. These were the optimal BMI values for lactation, coinciding with the median prepregnancy BMI in the study population (20.78 kg/m2 in primiparas and 20.06 kg/m2 in multiparas). The formula based on biomathematics might help establish the biological relationship between prepregnancy BMI and breastmilk volume. |
| キーワード | biomathematics body mass index expressed milk lactation |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-02 |
| 巻 | 75巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 63 |
| 終了ページ | 69 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33649615 |
| JaLCDOI | 10.18926/AMO/61428 |
|---|---|
| フルテキストURL | 75_1_9.pdf |
| 著者 | Gobara, Hideo| Yamamoto, Akira| Komakic, Toshiyuki| Kitayama, Toshiaki| Sakurai, Jun| Iguchi, Toshihiro| Matsui, Yusuke| Uka, Mayu| Tomita, Koji| Hiraki, Takao| Kanazawa, Susumu| |
| 抄録 | To assess the feasibility of needle tract ablation in liver tissue in ex vivo and in vivo animal models using a cryo-probe and electrosurgical device. The experimental device is made by inserting a cryoprobe through an intro-ducer sheath for insulation, with 2-cm of probe tip projecting out. A beagle liver was punctured by the device, and electric current was applied at 30-W with the electrosurgical knife touching the non-insulated device base. The discolored area of cut surface along the device was evaluated in 5 application-time groups (5 , 10 , 15 , 20, or 25 seconds). An ex vivo experiment was performed to determine an ablation algorithm with an appropriate application time by comparison with radiofrequency ablation (RFA) results. Thereafter, an in vivo experiment was performed to verify the algorithm’s feasibility. In the ex vivo model, the cut surface demonstrated different amounts of discolored area according to the application time. The total discolored area in the 20-seconds group was similar to that by RFA. In the in vivo model, the liver did not bleed, the total discolored area was similar to that ex vivo, and coagulation necrosis was confirmed by photomicrograph. Needle tract ablation can be per-formed using the experimental device and electrosurgical device. |
| キーワード | needle tract ablation cryoablation electrosurgical device animal liver |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-02 |
| 巻 | 75巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 9 |
| 終了ページ | 14 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 33649608 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Sivixay, Souliphone| Bai, Gaowa| Tsuruta, Takeshi| Nishino, Naoki| |
| キーワード | diet gut microbiota protein prebiotics |
| 発行日 | 2021-01-14 |
| 出版物タイトル | AIMS Microbiology |
| 巻 | 7巻 |
| 号 | 1号 |
| 出版者 | AIMS Press |
| 開始ページ | 1 |
| 終了ページ | 12 |
| ISSN | 2471-1888 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2021 the Author(s) |
| 論文のバージョン | publisher |
| DOI | 10.3934/microbiol.2021001 |
| Web of Science KeyUT | 000608483600001 |
| 関連URL | isVersionOf https://doi.org/10.3934/microbiol.2021001 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Nguyen, Thuong Thi| Wu, Haoming| Nishino, Naoki| |
| キーワード | Cowshed Dairy Cow Microbiota Milk Season |
| 発行日 | 2019-12-24 |
| 出版物タイトル | Animal Bioscience |
| 巻 | 33巻 |
| 号 | 11号 |
| 出版者 | Asian-Australasian Journal of Animal Sciences |
| 開始ページ | 1858 |
| 終了ページ | 1865 |
| ISSN | 1011-2367 |
| NCID | AA10742423 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2020 by Asian-Australasian Journal of Animal Sciences |
| 論文のバージョン | publisher |
| PubMed ID | 32054182 |
| DOI | 10.5713/ajas.19.0506 |
| Web of Science KeyUT | 000582676500017 |
| 関連URL | isVersionOf https://doi.org/10.5713/ajas.19.0506 |
| フルテキストURL | JCR_230_fulltext.pdf |
|---|---|
| 著者 | Sakai, Satoshi| Iwata, Caname| Tanaka, Hiroyoshi Y.| Cabral, Horacio| Morishita, Yasuyuki| Miyazon, Kohei| Kano, Mitsunobu R.| |
| キーワード | Macromolecular drugs Drug distribution Pancreatic ductal adenocarcinoma Fibrosis FGF-2 |
| 発行日 | 2016-05-28 |
| 出版物タイトル | Journal of Controlled Release |
| 巻 | 230巻 |
| 出版者 | Elsevier |
| 開始ページ | 109 |
| 終了ページ | 115 |
| ISSN | 0168-3659 |
| NCID | AA10458678 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| PubMed ID | 27080571 |
| DOI | 10.1016/j.jconrel.2016.04.007 |
| Web of Science KeyUT | 000375412500012 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.jconrel.2016.04.007 |
| JaLCDOI | 10.18926/AMO/58269 |
|---|---|
| フルテキストURL | 74_2_115.pdf |
| 著者 | Kotani, Sayoko| Kamada, Yasuhiko| Shimizu, Keiko| Sakamoto, Ai| Nakatsuka, Mikiya| Hiramatsu, Yuji| Masuyama, Hisashi| |
| 抄録 | Thrombosis in decidual vessels is one of the mechanisms of pregnancy loss. However, few studies have assessed the relation between platelet activation, which is known to cause of thrombosis, and recurrent pregnancy loss (RPL). We investigated platelet activation in women with RPL compared to controls by measuring plasma levels of platelet factor 4 (PF4) and β-thromboglobulin (βTG), and assessed correlations between PF4/βTG and coagulative risk factors associated with RPL. The study group included 135 women who had experienced two or more consecutive pregnancy losses. The control group included 28 age-matched healthy women who had never experienced pregnancy loss. PF4 and βTG plasma levels were significantly higher in the women with RPL than controls (PF4: 14.0 [8.0-20.0] vs. 9.0 [6.0-12.0] ng/ml, p=0.043; βTG: 42.0 [24.3-59.8] vs. 31.5 [26.6-36.4] ng/ml, p=0.002). There was a significant association between βTG and anti-phosphatidylethanolamine antibody immunoglobulin M (aPE IgM) (p=0.048). Among the women with RPL, 18 of those who were positive for PF4 (45%) and 18 of those who were positive for βTG (37%) were negative for all known coagulative risk factors associated with RPL. Measurements of PF4 and βTG may be important because they help identify women who are at risk of RPL. |
| キーワード | recurrent pregnancy loss platelet factor 4 β-thromboglobulin platelet activation |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-04 |
| 巻 | 74巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 115 |
| 終了ページ | 122 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32341585 |
| Web of Science KeyUT | 000528278500004 |
| NAID | 120006839448 |
| フルテキストURL | ApplEntomolZool_2019_00643.pdf |
|---|---|
| 著者 | Terada, Kenji| Matsumura, Kentarou| Miyatake, Takahisa| |
| キーワード | Temperature Experimental evolution Hatching rate Seed beetle Callosobruchus chinensis |
| 備考 | This is an Accepted Manuscript of an article published by Springer Japan| |
| 発行日 | 2019-09-13 |
| 出版物タイトル | Applied Entomology and Zoology |
| 巻 | 54巻 |
| 出版者 | Springer Japan |
| 開始ページ | 459 |
| 終了ページ | 464 |
| ISSN | 00036862 |
| NCID | AA00543238 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| DOI | 10.1007/s13355-019-00643-z |
| NAID | 40022061862 |
| Web of Science KeyUT | 000503219100014 |
| 関連URL | isVersionOf https://doi.org/10.1007/s13355-019-00643-z |
| JaLCDOI | 10.18926/AMO/56930 |
|---|---|
| フルテキストURL | 73_4_285.pdf |
| 著者 | Otani, Yoshihiro| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Date, Isao| |
| 抄録 | Gliomas are characterized as highly diffuse infiltrating tumors, and currently available treatments such as surgery, radiation and chemotherapy are unfeasible or show limited efficacy against these tumors. Recent genetic and epigenetic analyses of glioma have revealed increasing evidence of the role of driver genetic alterations in glioma development and led to the identification of prognostic factors. Despite these findings, the survival rates of glioma patients remain low, and alternative treatments and novel targets are needed. Recent studies identified neural stem cells as the possible origin of gliomas, and some evidence has revealed shared functions and mechanisms between glioma cells and neurons, also supporting their similarity. The cytoskeleton plays important roles in the migration of normal cells as well as cancer cells. Recent reports have described a role for microtubules, a component of the cytoskeleton, in glioma invasion. Notably, several factors that regulate microtubule functions, such as microtubule-associated proteins, plus-end tracking proteins, or motor proteins, are upregulated in glioma tissues compared with normal tissue, and upregulation of these factors is associated with high invasiveness of glioma cells. In this review, we describe the mechanism of microtubules in glioma invasion and discuss the possibility of microtubule-targeted therapy to inhibit glioma invasion. |
| キーワード | glioma cytoskeletons invasion microtubules |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-08 |
| 巻 | 73巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 285 |
| 終了ページ | 297 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31439951 |
| JaLCDOI | 10.18926/AMO/56860 |
|---|---|
| フルテキストURL | 73_3_189.pdf |
| 著者 | Sakamoto, Shinji| Kawai, Hiroki| Okahisa, Yuko| Tsutsui, Ko| Kanbayashi, Takashi| Tanaka, Keiko| Mizuki, Yutaka| Takaki, Manabu| Yamada, Norihito| |
| 抄録 | Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a recently-discovered autoimmune disorder in which antibodies target NMDAR in the brain. The number of reported cases of anti-NMDAR encephalitis has increased rapidly. Anti-NMDAR encephalitis can be mistakenly diagnosed as psychiatric disorders because many patients present with prominent psychiatric symptoms and visit psychiatric institutions first. Thus, psychiatrists should cultivate a better understanding of anti-NMDAR encephalitis. In this review, we present the mechanisms, epidemiology, symptoms and clinical course, diagnostic tests, treatment and outcomes of patients with anti-NMDAR encephalitis. Furthermore, we discuss the diversity of clinical spectra of anti-NMDAR encephalitis, and demonstrate a differential diagnosis of psychiatric disease from the perspective of psychiatry. |
| キーワード | NMDAR encephalitis psychiatric symptom schizophrenia mood disorder |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-06 |
| 巻 | 73巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 189 |
| 終了ページ | 195 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31235965 |
| フルテキストURL | InfectGenetEvol_54_47.pdf |
|---|---|
| 著者 | Ghosh, Priyanka| Kumar, Dhirendra| Chowdhury, Goutam| Singh, Puneeta| Samanta, Prosenjit| Dutta, Shanta| Ramamurthy, T.| Sharma, N. C.| Sinha, Preety| Prasad, Yogendra| Shinoda, Sumio| Mukhopadhyay, Asish K.| |
| キーワード | Cholera Vibrio cholerae ctxAB promoter ctxB gyrA rstB rtxA tcpA |
| 発行日 | 2017-10 |
| 出版物タイトル | Infection, Genetics and Evolution |
| 巻 | 54巻 |
| 出版者 | Elsevier Science |
| 開始ページ | 47 |
| 終了ページ | 53 |
| ISSN | 15671348 |
| NCID | AA11697619 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| PubMed ID | 28625543 |
| DOI | 10.1016/j.meegid.2017.06.015 |
| Web of Science KeyUT | 000411461400006 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.meegid.2017.06.015 |