検索結果 473 件
| JaLCDOI | 10.18926/AMO/64126 |
|---|---|
| フルテキストURL | 76_6_743.pdf |
| 著者 | Tanaka, Masato| Suthar, Hardik| Desai, Dhvanit| Yamauchi, Taro| Arataki, Shinya| Fujiwara, Yoshihiro| Uotani, Koji| Oda, Yoshiaki| Misawa, Haruo| |
| 抄録 | We describe a floating technique via a posterolateral approach with intraoperative O-arm navigation to facilitate decompression of the spinal cord in thoracic myelopathy due to severe ossification of the posterior longitudinal ligament (OPLL). A 62-year-old man with myelopathy due to thoracic OPLL had left-leg muscle weakness, urinary disturbance, and spastic gait. Bilateral leg pain and gait disturbance had persisted for 2 years. He was successfully treated by the posterolateral OPLL floating procedure and posterior pedicle fixation under O-arm navigation. At a 2-year follow-up, manual muscle testing results and sensory function of the left leg had recovered fully. His cervical Japanese Orthopedic Association score had improved from 5/12 to 11/12. The novel intraoperative O-arm navigation-guided posterolateral floating procedure for thoracic OPLL is effective for achieving precise decompression and strong fixation with a posterior approach only and can provide an excellent result for severe thoracic OPLL without the risk of adverse events from intraoperative radiation. |
| キーワード | ossification of the posterior longitudinal ligament floating method navigation surgery C-arm free |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 743 |
| 終了ページ | 748 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549778 |
| Web of Science KeyUT | 000905195100016 |
| JaLCDOI | 10.18926/AMO/64121 |
|---|---|
| フルテキストURL | 76_6_705.pdf |
| 著者 | Higashikawa, Toshihiro| Ito, Tomohiko| Mizuno, Takurou| Ishigami, Keiichiro| Kuroki, Kengo| Maekawa, Naoto| Usuda, Daisuke| Izumida, Toshihide| Yamada, Shinya| Sangen, Ryusho| Hamada, Kazu| Kiyosawa, Jun| Saito, Atsushi| Iguchi, Masaharu| Kasamaki, Yuji| Nakahashi, Takeshi| Fukuda, Akihiro| Saito, Hitoshi| Kanda, Tsugiyasu| Okuro, Masashi| |
| 抄録 | The sodium glucose transporter 2 (SGLT2) inhibitor tofogliflozin is a glucose-lowering drug that causes the excretion of surplus glucose by inhibiting SGLT2. Because of tofogliflozin’s osmotic diuresis mechanism, patients’ serum electrolytes, body fluid levels, and cardiac function must be monitored. We retrospectively analyzed the cases of 64 elderly Japanese patients with type 2 diabetes mellitus (T2DM) who received tofogliflozin for 3 months. Their HbA1c, serum electrolytes (sodium, potassium, chloride), hematocrit, brain natriuretic peptide (cardiac volume load marker) and renin and aldosterone (RAA; an index of regulatory hormones involved in body fluid retention) were continuously monitored during the investigation period. Renal function and cardiac function (by echocardiography) were assessed throughout the period. HbA1c significantly decreased (β1=−0.341, p<0.0001, linear regression analysis [LRA]). Most of the hormonal, electrolyte, and physiological parameters were maintained throughout the study period. In these circumstances, E/e’ tended to decrease (β1=−0.382, p=0.13, LRA). Compared to the baseline, E/e’ was significantly decreased at 1 and 3 months (p<0.01, p<0.05). In the higher E/e’ group (E/e’≥10, n=34), E/e’ decreased significantly (β1=−0.63, p<0.05, LRA). ΔE/e’ was correlated with body-weight change during treatment (r=0.64, p<0.01). The 3-month tofogliflozin treatment improved glycemic control and diastolic function represented by E/e’ in T2DM patients, without affecting serum electrolytes, renal function, or RAA. No negative impacts on the patients were observed. Three-month tofogliflozin treatment lowered glucose and improved cardiac diastolic function. |
| キーワード | tofogliflozin SGLT2 inhibitor elderly patient HbA1c cardiac diastolic function |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 705 |
| 終了ページ | 713 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549773 |
| Web of Science KeyUT | 000905195100011 |
| JaLCDOI | 10.18926/AMO/64120 |
|---|---|
| フルテキストURL | 76_6_695.pdf |
| 著者 | Onishi, Hideki| Nouso, Kazuhiro| Takaki, Akinobu| Oyama, Atsushi| Adachi, Takuya| Wada, Nozomu| Takeuchi, Yasuto| Shiraha, Hidenori| Okada, Hiroyuki| |
| 抄録 | This study sought to identify factors that are predictive of a therapeutic response to hepatic arterial infusion chemotherapy (HAIC) by focusing on the number of prior transcatheter arterial chemoembolization (TACE) sessions. To determine the parameters predicting a good response to HAIC, we retrospectively analyzed 170 patients with hepatocellular carcinoma (HCC) who received HAIC regimens comprising low-dose cisplatin combined with 5-fluorouracil (LFP) or cisplatin (CDDP) for the first time. In both the LFP and CDDP regimens, the response rates were significantly lower in patients with three or more prior TACE sessions than in those with two or fewer prior TACE sessions (LFP 57% versus 28%; p=0.01, CDDP 27% versus 6%; p=0.01). Multivariable logistic regression analysis revealed that the number of prior TACE sessions (≥ 3) was significantly associated with non-responder status (odds ratio 4.17, 95% Confidence Interval (CI) 1.76-9.86) in addition to the HAIC regimen. Multivariable analysis using the Cox proportional hazards model revealed that a larger number of prior TACE sessions (≥ 3) was a significant risk factor for survival (hazard ratio 1.60, 95% CI 1.12-2.29) in addition to Child-Pugh class, serum alpha-fetoprotein concentration, and maximum diameter of HCC. HCC patients who receive fewer prior TACE sessions (≤ 2) were found to be better responders to HAIC. |
| キーワード | hepatic arterial infusion chemotherapy hepatocellular carcinoma refractory transcatheter arterial chemoembolization |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 695 |
| 終了ページ | 703 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549772 |
| Web of Science KeyUT | 000905195100010 |
| JaLCDOI | 10.18926/AMO/64118 |
|---|---|
| フルテキストURL | 76_6_679.pdf |
| 著者 | Asagi, Akinori| Sakaguchi, Chihiro| Nadano, Seijin| Nishina, Tomohiro| Hamamoto, Yasushi| Kataoka, Masaaki| Yamashita, Natsumi| Tanimizu, Masahito| Hyodo, Ichinosuke| |
| 抄録 | Chemotherapy is insufficient to treat macroscopic vascular invasion (MVI) of hepatocellular carcinoma (HCC). We retrospectively investigated the treatment outcomes of patients who underwent three-dimensional conformal radiotherapy (3D-CRT) for HCC MVI and analyzed prognostic factors by multivariate analysis using a Cox proportional hazard model. Sixty-five patients were studied. MVI sites were the portal vein (n=48 patients), portal and hepatic veins (n=8), and hepatic vein (n=9). The median irradiation dose was 50 Gy. The median survival time (MST) was 7.5 months. Performance status 2 or 3, modified albumin-bilirubin grade 2b or 3, and massive/diffuse type were poor prognostic factors. Nineteen patients (29%) with a treatment effect of 3 or 4 (≥ 50% of tumor necrosis or regression) at the irradiation sites according to the Response Evaluation Criteria in Cancer of the Liver showed longer survival than those with an effect of 1 or 2 (MST 18.7 vs. 5.9 months, p<0.001). No treatment-related death occurred. The hepatic function reserve was preserved in more than 70% of patients. 3D-CRT controlled HCC MVI safely and was suggested to be a good treatment option. |
| キーワード | hepatocellular carcinoma macroscopic vascular invasion portal vein tumor thrombosis hepatic vein tumor thrombosis three-dimensional conformal radiotherapy |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 679 |
| 終了ページ | 688 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549770 |
| Web of Science KeyUT | 000905195100008 |
| JaLCDOI | 10.18926/AMO/64116 |
|---|---|
| フルテキストURL | 76_6_661.pdf |
| 著者 | Abe, Yuko| Taira, Naruto| Kashiwabara, Kosuke| Tsurutani, Junji| Kitada, Masahiro| Takahashi, Masato| Kato, Hiroaki| Kikawa, Yuichiro| Sakata, Eiko| Naito, Yoichi| Hasegawa, Yoshie| Saito, Tsuyoshi| Iwasa, Tsutomu| Takashima, Tsutomu| Aihara, Tomohiko| Mukai, Hirofumi| Hara, Fumikata| Shien, Tadahiko| Doihara, Hiroyoshi| Toyooka, Shinichi| |
| 抄録 | Chemotherapy-induced peripheral neuropathy (CIPN) is an important clinical challenge that threatens patients’ quality of life. This sub-study of the ABROAD trial investigated the influence of single nucleotide polymorphisms (SNPs) on CIPN, using genotype data from a randomized study to determine the optimal dose of a 3-week-cycle regimen of nab-paclitaxel (q3w nab-PTX) in patients with metastatic breast cancer (MBC). Patients with HER2-negative MBC were randomly assigned to three doses of q3w nab-PTX (SD: 260 mg/m2 vs. MD: 220 mg/m2 vs. LD: 180 mg/m2). Five SNPs (EPHA4-rs17348202, EPHA5-rs7349683, EPHA6-rs301927, LIMK2-rs5749248, and XKR4-rs4737264) were analyzed based on the results of a previous genome-wide association study. Per-allele SNP associations were assessed by a Cox regression to model the cumulative dose of nab-PTX up to the onset of severe or worsening sensory neuropathy. A total of 141 patients were enrolled in the parent study; 91(65%) were included in this sub-study. Worsening of CIPN was significantly greater in the cases with XKR4 AC compared to those with a homozygote AA (HR 1.86, 95%CI: 1.00001−3.46, p=0.049). There was no significant correlation of CIPN with any other SNP. A multivariate analysis showed that the cumulative dose of nab-PTX was most strongly correlated with CIPN (p<0.01). |
| キーワード | metastatic breast cancer taxane-induced peripheral neuropathy chemotherapy-induced peripheral neuropathy nab-paclitaxel single nucleotide polymorphism |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 661 |
| 終了ページ | 671 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549768 |
| Web of Science KeyUT | 000905195100006 |
| フルテキストURL | K0006690_abstract_review.pdf K0006690_fulltext.pdf K0006690_summary.pdf |
|---|---|
| 著者 | 突沖 貴宏| |
| 発行日 | 2022-09-22 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第6690号 |
| 学位授与年月日 | 2022-09-22 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| 著作権者 | © The Author(s) 2020 |
| JaLCDOI | 10.18926/AMO/64044 |
|---|---|
| フルテキストURL | 76_5_609.pdf |
| 著者 | Matsumoto, Ken| Fujishita, Keigo| Matsuda, Masayuki| Oka, Satoshi| Fujisawa, Yuka| Imai, Toshi| Machida, Takuya| |
| 抄録 | A 69-year-old Japanese man with acute leukemia received post-transplant cyclophosphamide-based haploidentical stem cell transplantation (PTCY-haplo-SCT) but was readmitted with dyspnea and ground-glass-opacities of the lungs. Bronchoscopy showed inflammatory changes with no signs of infection. He received steroids but required intubation as his condition deteriorated. In addition to antithymocyte globulin and cyclophosphamide, we administered ruxolitinib but failed to save him. Autopsy findings revealed fibrotic nonspecific interstitial pneumonia (NSIP) without evidence of organizing pneumonia or infection. Thus, we diagnosed idiopathic pneumonia syndrome (IPS). As far as our knowledge, this is the first case of IPS with NSIP histology after PTCY-haplo-SCT. |
| キーワード | idiopathic pneumonia syndrome ruxolitinib post-transplant cyclophosphamide-based haploidentical stem cell transplantation nonspecific interstitial pneumonia |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-10 |
| 巻 | 76巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 609 |
| 終了ページ | 615 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36352810 |
| Web of Science KeyUT | 000884907100016 |
| JaLCDOI | 10.18926/AMO/64040 |
|---|---|
| フルテキストURL | 76_5_585.pdf |
| 著者 | Choshi, Haruki| Watanabe, Mototsugu| Furukawa, Shinichi| Ujike, Hiroyuki| Kataoka, Kazuhiko| |
| 抄録 | Pulmonary metastatic resection is a standard therapy for renal cell carcinoma (RCC). Although patients with pulmonary metastases who do not undergo any treatment have poor prognoses, it has been reported that resection for pulmonary metastases yields good clinical outcomes. We investigated the prognoses of the 10 Japanese patients (eight males, two females) who underwent a surgical resection of pulmonary metastasectomy from RCC at our institution between April 1, 2012 and March 31, 2020 and analyzed the prognostic factors. We determined the prognoses and calculated the 5-year overall survival (OS) and disease-free survival (DFS) rates. To identify prognostic factors, we compared the median DFS duration for each factor. Elderly patients (median age, 75.5 years) were more predominant compared to previous studies, and all 10 patients underwent a complete resection. The 5-year DFS rate was 30.5% (95%CI: 0.045-0.63) and the 5-year OS rate was 80% (95%CI: 0.20-0.97). The following factors were associated with better prognosis: female, disease-free interval≥36 months, and metastases size<12 mm. These results indicate that complete resection for pulmonary metastases from RCC resulted in good clinical outcomes, particularly for patients with better prognostic factors. |
| キーワード | renal cell carcinoma pulmonary metastasis complete resection |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-10 |
| 巻 | 76巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 585 |
| 終了ページ | 591 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36352806 |
| Web of Science KeyUT | 000884907100012 |
| JaLCDOI | 10.18926/AMO/64033 |
|---|---|
| フルテキストURL | 76_5_527.pdf |
| 著者 | Makihara, Seiichiro| Kariya, Shin| Miyamoto, Shotaro| Uraguchi, Kensuke| Oka, Aiko| Tsumura, Munechika| Noda, Yohei| Ando, Mizuo| Okano, Mitsuhiro| |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-10 |
| 巻 | 76巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 527 |
| 終了ページ | 533 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36352799 |
| Web of Science KeyUT | 000884907100005 |
| JaLCDOI | 10.18926/AMO/64031 |
|---|---|
| フルテキストURL | 76_5_511.pdf |
| 著者 | Tomita, Hayato| Kuramochi, Kenji| Fujikawa, Atsuko| Ikeda, Hirotaka| Komita, Midori| Kurihara, Yoshiko| Kobayashi, Yasuyuki| Mimura, Hidefumi| |
| 抄録 | Iterative reconstruction (IR) improves image quality compared with filtered back projection (FBP). This study investigated the usefulness of model-based IR (forward-projected model-based iterative reconstruction solution [FIRST]) in comparison with FBP and hybrid IR (adaptive iterative dose reduction three-dimensional processing [AIDR 3D]) in low-dose paranasal CT. Twenty-four patients with paranasal sinusitis who underwent standard-dose CT (120 kV) and low-dose CT (100 kV) scanning before and after medical treatment were enrolled. Standard-dose CT scans were reconstructed with FBP (FBP120), and low-dose CT scans with FBP (FBP100), AIDR 3D, and FIRST. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) in three anatomical structures and effective doses were compared using Mann–Whitney U test. Two radiologists independently evaluated the visibility of 16 anatomical structures, overall image quality, and artifacts. Effective doses in lowdose CT were significantly reduced compared with those in standard-dose CT (0.24 vs 0.43 mSv, p<0.001). FIRST achieved significantly higher SNR (p<0.01, respectively) and CNR (p<0.001, respectively) of evaluated structures and significant improvement in overall image quality (p<0.001), artifacts (p<0.001), and visibility related to muscles (p<0.05) compared to FBP120, FBP100, and AIDR 3D. FIRST allowed radiation-dose reduction, while maintaining objective and subjective image quality in low-dose paranasal CT. |
| キーワード | paranasal sinuses iterative reconstruction dose reduction low dose |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-10 |
| 巻 | 76巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 511 |
| 終了ページ | 517 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36352797 |
| Web of Science KeyUT | 000884907100003 |
| JaLCDOI | 10.18926/bgeou/63922 |
|---|---|
| タイトル（別表記） | Development of Discussion Instruction with Inevitable Use of ICT in Japanese Language Studies at High School: Setting up a “Non-private Relationship” Place Through Connections Between Different Schools |
| フルテキストURL | bgeou_180_039_047.pdf |
| 著者 | 池田 匡史| 三樹 亮太| 里村 啓| |
| 抄録 | 国語教育学研究における話し合い指導は，現実的な制約から教室内の関係の中で展開されるものにとどまっていた。その結果，公的な関係での話し合いの場が設定されにくい現状にあった。しかしながら，ICTの活用を通して学校間を繋ぐことによって，関係性の築き上げられていない関係での話し合いの場の設定が可能になる。そこで，ICTの活用による文字化資料の作成の効率化などの利点も取り入れながら，実際に県を跨いで高等学校間を接続し，話し合いを行うとともに，その話し合いの対象化を行う実践を開発，展開した。結果，学習者は学校間の接続に肯定的な評価を示すとともに，方法知の獲得の土台となるであろう認識を獲得したことを明らかにした。 |
| キーワード | 話し合い 文字化資料 学校間交流 ICTの活用 公的な関係性 |
| 出版物タイトル | 岡山大学大学院教育学研究科研究集録 |
| 発行日 | 2022-08-26 |
| 巻 | 180巻 |
| 開始ページ | 39 |
| 終了ページ | 47 |
| ISSN | 1883-2423 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| JaLCDOI | 10.18926/AMO/63908 |
|---|---|
| フルテキストURL | 76_4_479.pdf |
| 著者 | Ogawa, Chikako| Hirasawa, Akira| Sogawa, Reimi| Hasuoka, Kayoko| Tomida, Shuta| Futagawa, Mashu| Urakawa, Yusaku| Kochi, Mariko| Yamamoto, Hideki| Nakamura, Keiichiro| Masuyama, Hisashi| |
| 抄録 | A hereditary breast and ovarian cancer (HBOC) pedigree was detected via liquid biopsy, and cancer prevention was initiated for the patient’s daughter, after receiving a definitive result from BRCA genetic testing. A 48-yearold woman with ovarian cancer was administered precision medicine, which used cell-free DNA from plasma. The results revealed a pathogenic variant of BRCA1 as a presumed germline pathogenic mutation. We confirmed the germline pathological variant BRCA1 c.81-1G> A and suggested treatment with a PARP inhibitor. One of her three children had the variant, was diagnosed as an unaffected pathogenic variant carrier, and was advised to initiate surveillance. |
| キーワード | hereditary breast and ovarian cancer (HBOC) BRCA 1 presumed germline pathogenic variants (PGPV) germline findings cancer precision medicine |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 479 |
| 終了ページ | 483 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123164 |
| Web of Science KeyUT | 000882167300012 |
| JaLCDOI | 10.18926/AMO/63894 |
|---|---|
| フルテキストURL | 76_4_399.pdf |
| 著者 | Kajiwara, Yukiko| Iwamoto, Takayuki| Zhu, Yidan| Kochi, Mariko| Shien, Tadahiko| Taira, Naruto| Doihara, Hiroyoshi| Toyooka, Shinichi| |
| 抄録 | According to a recent report, a low Ki67 level after short-term preoperative hormone therapy (post-Ki67) might suggest a more favorable prognosis compared with a high post-Ki67 level in patients with hormone receptorpositive/human epidermal growth factor 2-negative (HR+/HER2−) breast cancer with high levels of Ki67. This study aimed to evaluate the pre-treatment genetic differences between these two patient groups. Forty-five luminal B-like patients were stratified into two groups, namely, a group with high (H→H) and one with low (H→L) Ki67 levels after short-term preoperative aromatase inhibitor (AI) treatment. We compared pre-treatmentgene expression profiles between the two groups. In gene level analysis, there was no significant difference between the two groups by the class comparison test. In pathway analysis, five metabolism-related gene sets were significantly upregulated in the H→L group (p≤0.05). In the search for novel targets, five genes (PARP, BRCA2, FLT4, CDK6, and PDCD1LG2) showed significantly higher expression in the H→H group (p≤0.05). Several metabolism-related pathways were associated with sensitivity to AI. In the future, it will be necessary to seek out new therapeutic strategies for the poor prognostic group with high post-Ki67. |
| キーワード | breast cancer short-term hormone therapy gene expression profiling Ki-67 targeted therapy |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 399 |
| 終了ページ | 408 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123154 |
| Web of Science KeyUT | 000882167300005 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Tsuge, Mitsuru| Ikeda, Masanori| Tsukahara, Hirokazu| |
| キーワード | bronchial asthma chronic obstructive pulmonary disease lung function trajectory type 2 inflammation airway remodeling omalizumab mepolizumab benralizumab dupilumab |
| 発行日 | 2022-08-19 |
| 出版物タイトル | Children - Basel |
| 巻 | 9巻 |
| 号 | 8号 |
| 出版者 | MDPI |
| 開始ページ | 1253 |
| ISSN | 2227-9067 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 36010143 |
| DOI | 10.3390/children9081253 |
| Web of Science KeyUT | 000846009500001 |
| 関連URL | isVersionOf https://doi.org/10.3390/children9081253 |
| フルテキストURL | fulltext20220708-1.pdf |
|---|---|
| 著者 | NAKAMURA, Eizo| KOBAYASHI, Katsura| TANAKA, Ryoji| KUNIHIRO, Tak| KITAGAWA, Hiroshi| POTISZIL, Christian| OTA, Tsutomu| SAKAGUCHI, Chie| YAMANAKA, Masahiro| RATNAYAKE, Dilan M.| TRIPATHI, Havishk| KUMAR, Rahul| AVRAMESCU, Maya-Liliana| TSUCHIDA, Hidehisa| YACHI, Yusuke| MIURA, Hitoshi| ABE, Masanao| FUKAI, Ryota| FURUYA, Shizuho| HATAKEDA, Kentaro| HAYASHI, Tasuku| HITOMI, Yuya| KUMAGAI, Kazuya| MIYAZAKI, Akiko| NAKATO, Aiko| NISHIMURA, Masahiro| OKADA, Tatsuaki| SOEJIMA, Hiromichi| SUGITA, Seiji| SUZUKI, Ayako| USUI, Tomohiro| YADA, Toru| YAMAMOTO, Daiki| YOGATA, Kasumi| YOSHITAKE, Miwa| ARAKAWA, Masahiko| FUJII, Atsushi| HAYAKAWA, Masahiko| HIRATA, Naoyuki| HIRATA, Naru| HONDA, Rie| HONDA, Chikatoshi| HOSODA, Satoshi| IIJIMA, Yu-ichi| IKEDA, Hitoshi| ISHIGURO, Masateru| ISHIHARA, Yoshiaki| IWATA, Takahiro| KAWAHARA, Kosuke| KIKUCHI, Shota| KITAZATO, Kohei| MATSUMOTO, Koji| MATSUOKA, Moe| MICHIKAMI, Tatsuhiro| MIMASU, Yuya| MIURA, Akira| MOROTA, Tomokatsu| NAKAZAWA, Satoru| NAMIKI, Noriyuki| NODA, Hirotomo| NOGUCHI, Rina| OGAWA, Naoko| OGAWA, Kazunori| OKAMOTO, Chisato| ONO, Go| OZAKI, Masanobu| SAIKI, Takanao| SAKATANI, Naoya| SAWADA, Hirotaka| SENSHU, Hiroki| SHIMAKI, Yuri| SHIRAI, Kei| TAKEI, Yuto| TAKEUCHI, Hiroshi| TANAKA, Satoshi| TATSUMI, Eri| TERUI, Fuyuto| TSUKIZAKI, Ryudo| WADA, Koji| YAMADA, Manabu| YAMADA, Tetsuya| YAMAMOTO, Yukio| YANO, Hajime| YOKOTA, Yasuhiro| YOSHIHARA, Keisuke| YOSHIKAWA, Makoto| YOSHIKAWA, Kent| FUJIMOTO, Masaki| WATANABE, Sei-ichiro| TSUDA, Yuichi| |
| 発行日 | 2022-06-10 |
| 出版物タイトル | Proceedings of the Japan Academy, Series B |
| 巻 | 98巻 |
| 号 | 6号 |
| 出版者 | Japan Academy |
| 開始ページ | 227 |
| 終了ページ | 282 |
| ISSN | 0386-2208 |
| NCID | AA00785485 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | ©2022 The Author(s). |
| 論文のバージョン | author |
| PubMed ID | 35691845 |
| DOI | 10.2183/pjab.98.015 |
| Web of Science KeyUT | 000812946100001 |
| 関連URL | isVersionOf https://doi.org/10.2183/pjab.98.015 |
| JaLCDOI | 10.18926/AMO/63745 |
|---|---|
| フルテキストURL | 76_3_339.pdf |
| 著者 | Yano, Akihiko| Sada, Ken-ei| Sawada, Tsutomu| Ito, Hideki| Yano, Hiroko| Ikeda, Tatsuya| |
| 抄録 | A 90-year-old man presented with muscle weakness, difficulty concentrating, and dysphagia. About eighteen months prior to presentation, lansoprazole had been initiated to prevent stress ulcers; he also had a history of total thyroidectomy due to papillary thyroid cancer ten years prior. Laboratory findings were as follows: K 2.4 mEq/L, Ca 3.7 mg/dL, Mg 1.3 mg/dL, CK 5386 U/L, and intact PTH (iPTH) 14 pg/mL. Rhabdomyolysis with multiple electrolyte imbalances under proton pump inhibitor (PPI) treatment was diagnosed. We initiated intravenous hydration and electrolyte supplementation with discontinuation of PPI. After discontinuing PPI, the patient’s serum magnesium, potassium, and calcium levels normalised with oral vitamin D and calcium supplementation. PPIs can cause hypocalcaemia and hypokalaemia via hypomagnesemia; hypocalcaemia is also a common postoperative complication of thyroidectomy. Careful monitoring of electrolyte levels is required in patients with long-term PPI treatment, especially in post-thyroidectomy cases. |
| キーワード | hypocalcaemia thyroidectomy proton pump inhibitors hypomagnesemia rhabdomyolysis |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-06 |
| 巻 | 76巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 339 |
| 終了ページ | 342 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35790366 |
| Web of Science KeyUT | 000823568300014 |
| JaLCDOI | 10.18926/AMO/63740 |
|---|---|
| フルテキストURL | 76_3_307.pdf |
| 著者 | Sugiura, Satoshi| Kitamura, Yoshihisa| Izushi, Yasuhisa| Ushio, Soichiro| Sendo, Toshiaki| |
| 抄録 | In recent years, medical staff including physicians and nurses have been participating in home health care, reflecting the needs of an aging society in Japan. Pharmacists are also asked to work on home health care teams to ensure the medical safety of patients. It currently remains unclear whether direct communication, i.e. a meeting, between home-visiting physicians and pharmacists contributes to the proper use of medications and continuous medical care. We retrospectively analyzed the medication management guidance records of home-visited patients who received their first home visit between April 2014 and March 2017. We collected data on pharmacist inquiries, the duration of visits, and details from a meeting between home-visiting physicians and pharmacists. Thirty-five patients were included. At the first visit, the inquiry rate by pharmacists was 65.7%. The prescription question rate was significantly lower in patients with a meeting than in those without (p=0.033). The average duration of visits was significantly shorter for home-visited patients whose health care providers had a meeting (p=0.007). These results suggest that pharmacists who held a meeting with the home-visiting physician before the first patient visit were able to resolve drug-related issues earlier, which increased the work efficiency of home-visiting pharmacists. |
| キーワード | home visit pharmacist meeting inquiry home health care |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-06 |
| 巻 | 76巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 307 |
| 終了ページ | 315 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35790361 |
| Web of Science KeyUT | 000823568300001 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Muzembo, Basilua Andre| Ntontolo, Ngangu Patrick| Ngatu, Nlandu Roger| Khatiwada, Januka| Suzuki, Tomoko| Wada, Koji| Kitahara, Kei| Ikeda, Shunya| Miyoshi, Shin-Ichi| |
| キーワード | Ebola knowledge attitudes practices beliefs misperceptions rumors sub-Saharan Africa |
| 発行日 | 2022-04-13 |
| 出版物タイトル | International Journal Of Environmental Research and Public Health |
| 巻 | 19巻 |
| 号 | 8号 |
| 出版者 | MDPI |
| 開始ページ | 4714 |
| ISSN | 1660-4601 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 35457585 |
| DOI | 10.3390/ijerph19084714 |
| Web of Science KeyUT | 000785094500001 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijerph19084714 |
| JaLCDOI | 10.18926/AMO/63410 |
|---|---|
| フルテキストURL | 76_2_167.pdf |
| 著者 | Higashionna, Tsukasa| Ushio, Soichiro| Esumi, Satoru| Murakawa, Kiminaka| Kitamura, Yoshihisa| Sendo, Toshiaki| |
| 抄録 | Febrile neutropenia (FN) is a serious side effect in patients undergoing cancer chemotherapy and frequently proves fatal. Since infection control is crucial in the management of FN, the antimicrobial agent cefozopran (CZOP) has been recommended but not approved for routine use in clinical care of FN in Japan. However, few studies of CZOP in the management of FN have used a thrice daily dose schedule. The aim of this study was to retrospectively compare the efficacy and safety of CZOP at a dose of 1 g three times daily to those of cefepime (CFPM) in the treatment of FN in our lung cancer patients. The response rates of the CZOP and CFPM groups were 89.5% (17/19 cases) and 83.0% (39/47 cases), respectively, with no significant difference between the two groups. The median duration of antimicrobial treatment was 6 days (4-10 days) in the CZOP group and 7 days (3-13 days) in the CFPM group, with no significant difference between groups. The incidence rates of adverse events were 21.1% (4/19 cases) in the CZOP group and 19.1% (9/47 cases) in the CFPM group. No adverse events of Grade 3 or higher were observed in either group. The findings of the present study suggest that CZOP administration at a dose of 1 g three times per day as an antimicrobial treatment alternative against FN. |
| キーワード | febrile neutropenia cefozopran cefepime lung cancer retrospective |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 167 |
| 終了ページ | 172 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503444 |
| Web of Science KeyUT | 000792374900008 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Kaneshiro, Nanaka| Komai, Masato| Imaoka, Ryosuke| Ikeda, Atsuya| Kamikubo, Yuji| Saito, Takashi| Saido, Takaomi C.| Tomita, Taisuke| Hashimoto, Tadafumi| Iwatsubo, Takeshi| Sakurai, Takashi| Uehara, Takashi| Takasugi, Nobumasa| |
| 発行日 | 2022-03-18 |
| 出版物タイトル | Iscience |
| 巻 | 25巻 |
| 号 | 3号 |
| 出版者 | Cell Press |
| 開始ページ | 103869 |
| ISSN | 2589-0042 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 The Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 35243232 |
| DOI | 10.1016/j.isci.2022.103869 |
| Web of Science KeyUT | 000773445100002 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.isci.2022.103869 |