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フルテキストURL fulltext.pdf
著者 Ikeda, Tomoka| Gion, Yuka| Sakamoto, Misa| Tachibana, Tomoyasu| Nishikori, Asami| Nishimura, Midori Filiz| Yoshino, Tadashi| Sato, Yasuharu|
キーワード Lymphoid tissues Lymphoma
発行日 2020-06-19
出版物タイトル Modern Pathology
33巻
12号
出版者 Springer Nature
開始ページ 2437
終了ページ 2448
ISSN 0893-3952
NCID AA1067307X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © Authors
論文のバージョン author
PubMed ID 32561847
DOI 10.1038/s41379-020-0599-8
Web of Science KeyUT 000541317200003
関連URL isVersionOf https://doi.org/10.1038/s41379-020-0599-8
フルテキストURL CCP_fulltext.pdf
著者 Tsukioki, Takahiro| Shien, Tadahiko| Tanaka, Takehiro| Suzuki, Yoko| Kajihara, Yukiko| Hatono, Minami| Kawada, Kengo| Kochi, Mariko| Iwamoto, Takayuki| Ikeda, Hirokuni| Taira, Naruto| Doihara, Hiroyoshi| Toyooka, Shinichi|
キーワード Breast cancer Metformin Preoperative Tils CD8 PD-L1
発行日 2020-06-12
出版物タイトル Cancer Chemotherapy and Pharmacology
86巻 86巻
1号 1号
出版者 Springer
開始ページ 55 55
終了ページ 63 63
ISSN 0344-5704
NCID AA00598397
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 ©Author(s)
論文のバージョン publisher
PubMed ID 32533334
DOI 10.1007/s00280-020-04092-2
Web of Science KeyUT 000539841500002
関連URL isVersionOf https://doi.org/10.1007/s00280-020-04092-2
JaLCDOI 10.18926/AMO/59961
フルテキストURL 74_3_261.pdf
著者 Nakahara, Keiichi| Ikeda, Tokunori| Takamatsu, Koutaro| Tawara, Nozomu| Hara, Kentaro| Enokida, Yuki| Tanoue, Naomi| Narita, Sawana| Fujii, Akiko| Yamanouchi, Yoshinori| Morinaga, Jun| Yamashita, Satoshi|
抄録 Muscle biopsy can be used to confirm the diagnosis of neuromuscular diseases. However, it is unclear whether antibiotic prophylaxis prior to muscle biopsy is needed to prevent surgical site infection (SSI). We are conducting a phase 2, single-center, open-labeled, prospective randomized trial to clarify the need for antibiotic prophylaxis in patients at low risk for SSI undergoing muscle biopsy. Patients will be randomized to an antibiotic prophylaxis group or a control group, and the incidence of SSI will be compared between the groups. Our findings will clarify the need for antibiotic prophylaxis in this patient population.
キーワード muscle biopsy antibiotic prophylaxis
Amo Type Clinical Study Protocol
出版物タイトル Acta Medica Okayama
発行日 2020-06
74巻
3号
出版者 Okayama University Medical School
開始ページ 261
終了ページ 264
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 32577026
Web of Science KeyUT 000543363400011
NAID 120006862802
JaLCDOI 10.18926/AMO/59960
フルテキストURL 74_3_257.pdf
著者 Hongo, Takashi| Ikeda, Fusao| Fujioka, Shinichi| Akatsuka, Riku| Fujiwara, Tosifumi| Yamamoto, Kazuhide|
抄録 A 65-year-old Japanese woman developed vesicular eruptions on her right ear due to varicella zoster virus (VZV) reactivation, followed by cranial polyneuritis and meningitis affecting her right cranial nerves V, VII, VIII, IX, and X. After acyclovir administration, her facial paralysis worsened. Intravenous methylprednisolone and vitamin C were administered on Day 4 post-admission. Her symptoms steadily improved, and by Day 45 she had fully recovered. Cranial polyneuritis is a rare complication of VZV reactivation, and there is no established method of treatment. This is the first report of full recovery from cranial polyneuritis using intravenous vitamin C as ancillary treatment.
キーワード varicella zoster virus polyneuritis vitamin C meningitis facial nerve palsy
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2020-06
74巻
3号
出版者 Okayama University Medical School
開始ページ 257
終了ページ 260
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 32577025
Web of Science KeyUT 000543363400010
NAID 120006862801
フルテキストURL fulltext.pdf
著者 Yamada, Keiko| Ito, Yoichi M.| Akagi, Masao| Chosa, Etsuo| Fuji, Takeshi| Hirano, Kenichi| Ikeda, Shinichi| Ishibashi, Hideaki| Ishibashi, Yasuyuki| Ishijima, Muneaki| Itoi, Eiji| Iwasaki, Norimasa| Izumida, Ryoichi| Kadoya, Ken| Kamimura, Masayuki| Kanaji, Arihiko| Kato, Hiroyuki| Kishida, Shunji| Mashima, Naohiko| Matsuda, Shuichi| Matsui, Yasumoto| Matsunaga, Toshiki| Miyakoshi, Naohisa| Mizuta, Hiroshi| Nakamura, Yutaka| Nakata, Ken| Omori, Go| Osuka, Koji| Uchio, Yuji| Ryu, Kazuteru| Sasaki, Nobuyuki| Sato, Kimihito| Senda, Masuo| Sudo, Akihiro| Takahira, Naonobu| Tsumura, Hiroshi| Yamaguchi, Satoshi| Yamamoto, Noriaki| Nakamura, Kozo| Takashi, Ohe|
発行日 2020-03-12
出版物タイトル Journal of Orthopaedic Science
出版者 Elsevier
ISSN 09492658
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2020 The Authors.
論文のバージョン publisher
PubMed ID 32173180
DOI 10.1016/j.jos.2020.01.011
フルテキストURL fulltext.pdf
著者 Katoh, Norito| Ohya, Yukihiro| Ikeda, Masanori| Ebihara, Tamotsu| Katayama, Ichiro| Saeki, Hidehisa| Shimojo, Naoki| Tanaka, Akio| Nakahara, Takeshi| Nagao, Mizuho| Hide, Michihiro| Fujita, Yuji| Fujisawa, Takao| Futamura, Masaki| Masuda, Koji| Murota, Hiroyuki| Yamamoto-Hanada, Kiwako|
キーワード Atopic dermatitis Clinical practice guidelines Eczema Evidence-based medicine Treatment
発行日 2020-04-04
出版物タイトル Allergology International
69巻
3号
出版者 Elsevier
開始ページ 356
終了ページ 369
ISSN 13238930
NCID AA11091750
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2020 Japanese Society of Allergology. Production and hosting by Elsevier B.V.
論文のバージョン publisher
PubMed ID 32265116
DOI 10.1016/j.alit.2020.02.006
関連URL IsVersionOf 10.1016/j.alit.2020.02.006
フルテキストURL fulltext.pdf
著者 Marti, Ll.| Ikeda, M.| Kato, Y.| Kishimoto, Y.| Nakahata, M.| Nakajima, Y.| Nakano, Y.| Nakayama, S.| Okajima, Y.| Orii, A.| Pronost, G.| Sekiya, H.| Shiozawa, M.| Tanaka, H.| Ueno, K.| Yamada, S.| Yano, T.| Yokozawa, T.| Murdoch, M.| Schuemann, J.| Vagins, M.R.| Bays, K.| Carminati, G.| Griskevich, N.J.| Kropp, W.R.| Locke, S.| Renshaw, A.| Smy, M.B.| Weatherly, P.| Ito, S.| Ishino, H.| Kibayashi, A.| Koshio, Y.| Mori, T.| Sakuda, M.| Yamaguchi, R.| Fernandez, P.| Labarga, L.| Bandac, I.| Perez, J.| Amey, J.| Litchfield, R.P.| Sztuc, A.| Uchida, Y.| Ma, W.Y.| Goldsack, A.| Simpson, C.| Wark, D.| Anthony, L.H.V.| McCauley, N.| Pritchard, A.| Di Lodovico, F.| Richards, B.| Cole, A.| Thiesse, M.| Thompson, L.| Imber, J.| Cao, S.V.| Ito, K.| Takeuchi, Y.| Akutsu, R.| Nishimura, Y.| Okumura, K.| Hirota, S.| Muto, F.| Yokoyama, M.| Suda, Y.| Zhang, H.|
発行日 2020-04-11
出版物タイトル Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
959巻
出版者 Elsevier
開始ページ 163549
ISSN 01689002
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2020 The Authors. Published by Elsevier B.V.
論文のバージョン publisher
DOI 10.1016/j.nima.2020.163549
Web of Science KeyUT 000518368800020
関連URL isVersionOf 10.1016/j.nima.2020.163549
フルテキストURL fulltext.pdf
著者 Kanazawa, Mai| Ikeda, Yoko| Nishihama, Ryuichi| Yamaoka, Shohei| Lee, Nam-Hee| Yamato, Katsuyuki T| Kohchi, Takayuk| Hirayama, Takashi|
キーワード Arabidopsis Marchantia polymorpha Mitochondria Poly(A) polymerase Poly(A) regulation Poly(A)-specific ribonuclease
備考 This is a pre-copyedited, author-produced version of an article accepted for publication in Plant and Cell Physiology following peer review. The version of record Mai Kanazawa et. al. Regulation of the Poly(A) Status of Mitochondrial mRNA by Poly(A)-Specific Ribonuclease Is Conserved among Land Plants. Plant and Cell Physiology 61(3), 470–480 (2020) is available online at: https://doi.org/10.1093/pcp/pcz212. |
発行日 2019-11-13
出版物タイトル Plant and Cell Physiology
61巻
3号
出版者 Oxford University Press
開始ページ 470
終了ページ 480
ISSN 00320781
NCID AA0077511X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 31722408
DOI 10.1093/pcp/pcz212
Web of Science KeyUT 000522855600004
関連URL isVersionOf https://doi.org/10.1093/pcp/pcz212
JaLCDOI 10.18926/AMO/58267
フルテキストURL 74_2_103.pdf
著者 Kawada, Yasumasa| Kubo, Toru| Baba, Yuichi| Hirota, Takayoshi| Tanioka, Katsutoshi| Yamasaki, Naohito| Kitaoka, Hiroaki|
抄録 This study examined whether switching from amlodipine and atorvastatin treatment using two pills to an equal dose of single-pill therapy is useful in Japanese outpatients. We retrospectively reviewed data obtained from 94 outpatients for whom treatment with two pills, namely amlodipine and atorvastatin, was switched to an equal dose of single-pill therapy in 11 hospitals. The criterion for enrollment in this study was that patients had switched their medication without changing other anti-hypertensive or anti-cholesterol drugs. Neither systolic nor diastolic blood pressure changed significantly after switching to an equal dose of single-pill therapy, whereas low-density lipoprotein (LDL) cholesterol levels significantly decreased after the medication was switched from 94±24 mg/dl to 89±17 mg/dl (p=0.015). A switch from medication with two separate pills of amlodipine and atorvastatin to an equal dose of single-pill therapy resulted in an overall decrease in LDL cholesterol. The results indicated that the switch to single-pill therapy might be a useful treatment.
キーワード hypertension dyslipidemia single-pill therapy
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2020-04
74巻
2号
出版者 Okayama University Medical School
開始ページ 103
終了ページ 108
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 32341583
Web of Science KeyUT 000528278500002
NAID 120006839446
フルテキストURL fulltext.pdf
著者 Suzuki, Yoko| Taniguchi, Kohei| Hatono, Minami| Kajiwara, Yukiko| Abe, Yuko| Kawada, Kengo| Tsukioki, Takahiro| Kochi, Mariko| Nishiyama, Keiko| Iwamoto, Takayuki| Ikeda, Hirokuni| Shien, Tadahiko| Taira, Naruto| Tabata, Masahiro| Yanai, Hiroyuki| Doihara, Hiroyoshi|
キーワード Radiation-induced angiosarcoma Radiotherapy Breast-conserving surgery Breast cancer Paclitaxel therapy Adjuvant therapy of angiosarcoma
発行日 2020-01-16
出版物タイトル Surgical Case Reports
6巻
1号
出版者 SpringerOpen
開始ページ 25
ISSN 2198-7793
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s). 2020
論文のバージョン publisher
PubMed ID 31950295
DOI 10.1186/s40792-020-0790-7
Web of Science KeyUT 000513920900001
関連URL isVersionOf https://doi.org/10.1186/s40792-020-0790-7
フルテキストURL fulltext.pdf fulltext2.pdf
著者 Fujii, Yosuke| Yashiro, Masato| Yamada, Mutsuko| Kikkawa, Tomonobu| Nosaka, Nobuyuki| Saito, Yukie| Tsukahara, Kohei| Ikeda, Masanori| Morishima, Tsuneo| Tsukahara, Hirokazu|
発行日 2018-03-14
出版物タイトル Disease Markers
出版者 Hindawi
開始ページ 2380179
ISSN 0278-0240
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2018 Yosuke Fujii et al.
論文のバージョン publisher
PubMed ID 29725488
DOI 10.1155/2018/2380179
Web of Science KeyUT 000428395400001
関連URL isVersionOf https://doi.org/10.1155/2018/2380179
フルテキストURL fulltext.pdf
著者 Yumoto, Tetsuya| Naitou, Hiromichi| Yorifuji, Takashi| Tahara, Yoshio| Yonemoto, Naohiro| Nonogi, Hiroshi| Nagao, Ken| Ikeda, Takanori| Sato, Naoki| Tsutsui, Hiroyuki|
キーワード out-of-hospital cardiac arrest outcome national meeting cardiopulmonary resuscitation
発行日 2019-12-16
出版物タイトル International Journal of Environmental Research and Public Health
16巻
24号
出版者 MDPI
開始ページ 5130
ISSN 1661-7827
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2019 by the authors.
論文のバージョン publisher
PubMed ID 31888125
DOI 10.3390/ijerph16245130
Web of Science KeyUT 000507312700245
関連URL isVersionOf https://doi.org/10.3390/ijerph16245130
フルテキストURL fulltext.pdf
著者 Ito, S.| Okada, T.| Takaku, Y.| Harada, M.| Ikeda, M.| Kishimoto, Y.| Koshio, Y.| Nakahata, M.| Nakajima, Y.| Sekiya, H.|
発行日 2019-06-29
出版物タイトル Progress of Theoretical and Experimental Physics
6号
出版者 Oxford University Press
開始ページ 063H03
ISSN 2050-3911
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2019.
論文のバージョン publisher
DOI 10.1093/ptep/ptz060
Web of Science KeyUT 000482307100015
関連URL isVersionOf https://doi.org/10.1093/ptep/ptz060
JaLCDOI 10.18926/AMO/57955
フルテキストURL 74_1_65.pdf
著者 Akiyama, Tomoyuki| Saigusa, Daisuke| Hyodo, Yuki| Umeda, Keiko| Saijo, Reina| Koshiba, Seizo| Kobayashi, Katsuhiro|
抄録 To characterize metabolic profiles within the central nervous system in epilepsy, we performed gas chromatography-tandem mass spectrometry (GC-MS/MS)-based metabolome analysis of the cerebrospinal fluid (CSF) in pediatric patients with and without epilepsy. The CSF samples obtained from 64 patients were analyzed by GC-MS/MS. Multivariate analyses were performed for two age groups, 0-5 years of age and 6-17 years of age, to elucidate the effects of epilepsy and antiepileptic drugs on the metabolites. In patients aged 0-5 years (22 patients with epilepsy, 13 without epilepsy), epilepsy patients had reduced 2-ketoglutaric acid and elevated pyridoxamine and tyrosine. In patients aged 6-17 years (12 with epilepsy, 17 without epilepsy), epilepsy patients had reduced 1,5-anhydroglucitol. Valproic acid was associated with elevated 2-aminobutyric acid, 2-ketoisocaproic acid, 4-hydroxyproline, acetylglycine, methionine, N-acetylserine, and serine. Reduced energy metabolism and alteration of vitamin B6 metabolism may play a role in epilepsy in young children. The roles of 1,5-anhydroglucitol in epilepsy in older children and in levetiracetam and zonisamide treatment remain to be explained. Valproic acid influenced the levels of amino acids and related metabolites involved in the metabolism of serine, methionine, and leucine.
キーワード antiepileptic drugs gas chromatography-tandem mass spectrometry metabolome analysis metabolomics
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2020-02
74巻
1号
出版者 Okayama University Medical School
開始ページ 65
終了ページ 72
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 32099251
Web of Science KeyUT 000516606200010
NAID 120006795622
フルテキストURL JCEH59_2_64.pdf
著者 Ikeda, Tomoka| Gion, Yuka| Yoshino, Tadashi| Sato, Yasuharu|
キーワード EBV-positive mucocutaneous ulcer clinical features immunosuppression pathological features
発行日 2019-06-28
出版物タイトル Journal of Clinical and Experimental Hematopathology
59巻
2号
出版者 Japanese Society for Lymphoratic Tissue Research
開始ページ 64
終了ページ 6471
ISSN 1346-4280
NCID AA11556796
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 Copyright © 2019 The Japanese Society for Lymphoreticular Tissue Research
論文のバージョン publisher
PubMed ID 31257347
DOI 10.3960/jslrt.18039
Web of Science KeyUT 000473169400004
関連URL isVersionOf https://doi.org/10.3960/jslrt.18039
フルテキストURL SR9_1_11934.pdf
著者 Takahara, Masahiro| Takaki, Akinobu| Hiraoka, Sakiko| Adach, Takuya| Shimomura, Yasuyuki| Matsushita, Hiroshi| Nguyen Tien Thi Thuy| Koike, Kazuko| Ikeda, Airi| Takashima, Shiho| Yamasaki, Yasushi| Inokuchi, Toshihiro| Kinugasa, Hideaki| Sugihara, Yusaku| Harada, Keita| Eikawa, Shingo| Morita, Hidetoshi| Udono, Heiichiro| Okada, Hiroyuki|
発行日 2019-8-15
出版物タイトル Scientific Reports
9巻
出版者 Nature Publishing Group
開始ページ 11934
ISSN 2045-2322
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2019
論文のバージョン publisher
PubMed ID 31417110
DOI 10.1038/s41598-019-48331-w
Web of Science KeyUT 000480680800048
関連URL isVersionOf https://doi.org/10.1038/s41598-019-48331-w
著者 Htoo Htoo Sandi Kyaw| Shwe Thinzar Aung| Hnin Aye Thant| Funabiki, Nobuo|
発行日 2018-07-19
出版物タイトル COMPLEX, INTELLIGENT, AND SOFTWARE INTENSIVE SYSTEMS
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/57720
フルテキストURL 73_6_537.pdf
著者 Takahara, Yasuhiro| Nishida, Keiichiro| Nakashima, Hirotaka| Ochi, Nobuaki| Uchida, Yoichiro| Kato, Hisayoshi| Itani, Satoru| Nakamura, Makoto| Iwasaki, Yuichi| Tsujimura, Yoshitaka|
抄録 High tibial osteotomy (HTO) procedure is generally contraindicated in rheumatoid arthritis (RA) patients because synovial inflammation may exacerbate joint damage post-surgery. The natural course of joint destruction in RA changed dramatically with new treatment strategies and the introduction of biologic disease-modifying anti-rheumatic drugs (bDMARDs). We report the cases of two RA patients who underwent HTO and whose disease activities were well controlled by bDMARDs. Despite their short follow-up periods, they showed acceptable objective and subjective clinical results. We believe that the combination of bDMARDs and HTO can be indicated for selected RA patients before total knee arthroplasty.
キーワード high tibial osteotomy rheumatoid arthritis biologic DMARD knee surgery
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2019-12
73巻
6号
出版者 Okayama University Medical School
開始ページ 537
終了ページ 542
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31871338
Web of Science KeyUT 000503431400011
JaLCDOI 10.18926/AMO/57375
フルテキストURL 73_5_441.pdf
著者 Watanabe, Toshiyuki| Sakurai, Toru| Mukai, Yuko| Kimata, Yoshihiro| Namba, Yuzaburo|
抄録 Gender dysphoria is a condition in which a discrepancy between biological sex and gender identity causes distress. Many female-to-male transsexuals (FTMTS) are uncomfortable with female breasts. Chest wall contouring surgery is effective for obtaining a male-type chest, reducing mental stress, and increasing sexual satisfaction in such cases. At the Okayama University Hospital Gender Center, we have obtained positive results using an algorithm to determine the most appropriate surgical method for chest wall contouring in FTMTS patients. However, serious complications requiring reoperation, such as hematoma, may still occur. Postoperative hematomas were found in 15 (4.18%) of 358 FTMTS patients who underwent chest contouring surgery at our hospital between 2006 and 2018. Postoperative hematoma was examined retrospectively. The median time to the onset of hematoma was 7 (6-12) h after the initial surgery. The main blood vessels causing bleeding were those in the head-side skin flap region where visual confirmation was difficult and the perforator vessels from the pectoralis major muscle. Intraoperative bleeding and the operation time had a significant impact on the onset of postoperative hematoma. This is the first retrospective study that investigated the blood vessels and other factors contributing to postoperative hematoma development after chest wall contouring.
キーワード female-to-male transsexuals chest wall contouring postoperative hematoma
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-10
73巻
5号
出版者 Okayama University Medical School
開始ページ 441
終了ページ 447
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31649371
Web of Science KeyUT 000491886600010
JaLCDOI 10.18926/AMO/57368
フルテキストURL 73_5_387.pdf
著者 Inoue, Miyabi| Yokoyama, Teruhiko|
抄録 To assess the efficacy and safety of 2 drugs for overactive bladder (OAB), solifenacin and mirabegron. Fortyseven female OAB patients were randomized into 2 groups. Twenty-three patients were initially prescribed solifenacin for 4 weeks, followed by mirabegron for 4 weeks (group S). The other 24 patients were initially prescribed mirabegron for 4 weeks, followed by solifenacin for 4 weeks (group M). Evaluations included clinical determination of the OAB symptom score (OABSS), International Prostate Symptom Score (IPSS), and Visual Analog Scale. The IPSS significantly improved after the administration of solifenacin in both groups. The OABSS significantly improved in both groups after 4 weeks. In group M, the OABSS after eight weeks was significantly improved compared to that after 4 weeks. However, in group S, it was not significantly improved. Twelve patients experienced adverse events during the solifenacin treatment, while 2 patients experienced adverse events during the mirabegron treatment. Both solifenacin and mirabegron led to improved OAB symptoms. Switching from mirabegron to solifenacin significantly improved the OABSS. However, mirabegron led to fewer adverse events than solifenacin. We recommend that mirabegron be prescribed first for OAB patients. If patients are not satisfied with mirabegron, solifenacin should be used.
キーワード overactive bladder, randomized crossover study solifenacin mirabegron
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-10
73巻
5号
出版者 Okayama University Medical School
開始ページ 387
終了ページ 392
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31649364
Web of Science KeyUT 000491886600003