検索結果 - 岡山大学学術成果リポジトリ

Programmable Clock Distribution Using Switching Matrices for Field Programmable Gate Arrays

フルテキストURL	fulltext.pdf
著者	Ogura, Ayumu\| Watanabe, Minoru\| Watanabe, Nobuya\|
キーワード	Clock distribution field programmable gate array (FPGA) programmable device two-phase clock
発行日	2026
出版物タイトル	IEEE Access
巻	14巻
出版者	Institute of Electrical and Electronics Engineers (IEEE)
開始ページ	52641
終了ページ	52653
ISSN	2169-3536
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2026 The Authors.
論文のバージョン	publisher
DOI	10.1109/access.2026.3678349
Web of Science KeyUT	001737491000044
関連URL	isVersionOf https://doi.org/10.1109/access.2026.3678349

Development of a generative AI agent for family support in implementing family-based treatment for children and adolescents with anorexia nervosa

フルテキストURL	fulltext.pdf
著者	Hanzawa, Mana\| Hasei, Joe\| Okada, Ayumi\| Tanaka, Chie\| Shigeyasu, Yoshie\| Fujii, Chikako\| Horiuchi, Makiko\| Sugihara, Akiko\| Takeuchi, Koichi\| Nakahara, Ryuichi\| Katayama, Hideki\| Takahashi, Yasushi\| Ozaki, Toshifumi\| Tsukahara, Hirokazu\|
キーワード	anorexia nervosa caregiver burden family support family-based treatment generative AI agent large language model retrieval-augmented generation
発行日	2026-03-09
出版物タイトル	Frontiers in Digital Health
巻	8巻
出版者	Frontiers Media SA
開始ページ	1759690
ISSN	2673-253X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2026 Hanzawa, Hasei, Okada, Tanaka, Shigeyasu, Fujii, Horiuchi, Sugihara, Takeuchi, Nakahara, Katayama, Takahashi, Ozaki and Tsukahara.
論文のバージョン	publisher
PubMed ID	41878376
DOI	10.3389/fdgth.2026.1759690
Web of Science KeyUT	001720251900001
関連URL	isVersionOf https://doi.org/10.3389/fdgth.2026.1759690

「有翼の天女図」十三考― 竹内栖鳳による東本願寺御影堂門の天井画とその周辺 ―

JaLCDOI	10.18926/70033
タイトル（別表記）	On Ten-nyo (Heavenly Maidens) with Wings, Part 13: The Ceiling of the Main Gate of the Higashi Hongan-ji Temple by Takeuchi Seiho and its Surroundings
フルテキストURL	hss_060_(021).pdf
著者	龍野　有子\|
出版物タイトル	岡山大学大学院社会文化科学研究科紀要
発行日	2025-12-10
巻	60巻
開始ページ	(21)
終了ページ	(39)
ISSN	1881-1671
言語	日本語
著作権者	Copyright (c) 2025 岡山大学大学院社会文化科学研究科
論文のバージョン	publisher

Bladder Trigone as a Sensory Hub: A Narrative Review

フルテキストURL	fulltext.pdf
著者	Sadahira, Takuya\| Maruyama, Yuki\| Mitsui, Yosuke\| Sekito, Takanori\| Watanabe, Tomofumi\| Watanabe, Masami\|
キーワード	bladder trigone botulinum toxin lower urinary tract symptoms sensory afferents varicosities
発行日	2025-10-19
出版物タイトル	Cureus
巻	17巻
号	10号
出版者	Springer Science and Business Media LLC
開始ページ	e94951
ISSN	2168-8184
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© Copyright 2025 Sadahira et al.
論文のバージョン	publisher
PubMed ID	41267700
DOI	10.7759/cureus.94951
関連URL	isVersionOf https://doi.org/10.7759/cureus.94951

Blood Pressure and Heart Rate Patterns Identified by Unsupervised Machine Learning and Their Associations with Subclinical Cerebral and Renal Damage in a Japanese Community: The Masuda Study

JaLCDOI	10.18926/AMO/69438
フルテキストURL	79_5_369.pdf
著者	Hisamatsu, Takashi\| Kinuta, Minako\| Munetomo, Sosuke\| Fukuda, Mari\| Kojima, Katsuhide\| Taniguchi, Kaori\| Nakahata, Noriko\| Kanda, Hideyuki\|
抄録	We applied unsupervised machine learning to analyze blood pressure (BP) and resting heart rate (HR) patterns measured during a 1-year period to assess their cross-sectional relationships with subclinical cerebral and renal target damage. Dimension reduction via uniform manifold approximation and projection, followed by K-means++ clustering, was used to categorize 362 community-dwelling participants (mean age, 56.2 years; 54.9% women) into three groups: Low BP and Low HR (Lo-BP/Lo-HR), High BP and High HR (Hi-BP/Hi-HR), and Low BP and High HR (Lo-BP/Hi-HR). Cerebral vessel lesions were defined as the presence of at least one of the following magnetic resonance imaging findings: lacunar infarcts, white matter hyperintensities, cerebral microbleeds, or intracranial artery stenosis. A high urinary albumin-to-creatinine ratio (UACR) was defined as the top 10% (≥ 12 mg/g) of the mean value from ≥2 measurements. Poisson regression with robust error variance, adjusted for demographics, lifestyle, and medical history, showed that the Hi-BP/Hi-HR group had relative risks of 3.62 (95% confidence interval, 1.75-7.46) for cerebral vessel lesions and 3.58 (1.33-9.67) for high UACR, and the Lo-BP/Hi-HR group had a relative risk of 3.09 (1.12-8.57) for high UACR, compared with the Lo-BP/Lo-HR group. These findings demonstrate the utility of an unsupervised, data-driven approach for identifying physiological patterns associated with subclinical target organ damage.
キーワード	blood pressure heart rate subclinical disease uniform manifold approximation and projection unsupervised machine learning
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2025-10
巻	79巻
号	5号
出版者	Okayama University Medical School
開始ページ	369
終了ページ	379
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2025 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	41126468
Web of Science KeyUT	001606013200007

Security in Post-Quantum Era: A Comprehensive Survey on Lattice-Based Algorithms

フルテキストURL	fulltext.pdf
著者	Nguyen, Hien\| Huda, Samsul\| Nogami, Yasuyuki\| Nguyen, Tuy Tan\|
キーワード	Post-quantum cryptography lattice-based cryptography number theoretic transform hardware and software implementation
発行日	2025-05-19
出版物タイトル	IEEE Access
巻	13巻
出版者	Institute of Electrical and Electronics Engineers (IEEE)
開始ページ	89003
終了ページ	89024
ISSN	2169-3536
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2025 The Authors.
論文のバージョン	publisher
DOI	10.1109/access.2025.3571307
Web of Science KeyUT	001498285200014
関連URL	isVersionOf https://doi.org/10.1109/access.2025.3571307

Commissioning of respiratory‐gated 4D dynamic dose calculations for various gating widths without spot timestamp in proton pencil beam scanning

フルテキストURL	fulltext.pdf suppl.pdf
著者	Tominaga, Yuki\| Wakisaka, Yushi\| Kato, Takahiro\| Ichihara, Masaya\| Yasui, Keisuke\| Sasaki, Motoharu\| Oita, Masataka\| Nishio, Teiji\|
キーワード	4D dynamic dose interplay effect pencil beam scanning proton therapy respiratory gating
発行日	2025-08
出版物タイトル	Medical Physics
巻	52巻
号	8号
出版者	Wiley
開始ページ	e18026
ISSN	0094-2405
NCID	AA00727671
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2025 The Author(s).
論文のバージョン	publisher
PubMed ID	40790932
DOI	10.1002/mp.18026
Web of Science KeyUT	001547587700001
関連URL	isVersionOf https://doi.org/10.1002/mp.18026

CNGC2 Negatively Regulates Stomatal Closure and Is Not Required for flg22- and H2O2-Induced Guard Cell [Ca2+]cyt Elevation in Arabidopsis thaliana

フルテキストURL	fulltext.pdf suppl.pdf
著者	Akter, Rojina\| Inoue, Yasuhiro\| Masumoto, Saori\| Mimata, Yoshiharu\| Matsuura, Takakazu\| Mori, Izumi C.\| Nakamura, Toshiyuki\| Nakamura, Yoshimasa\| Murata, Yoshiyuki\| Munemasa, Shintaro\|
キーワード	calcium signaling CNGC stomata
発行日	2025-07
出版物タイトル	Physiologia Plantarum
巻	177巻
号	4号
出版者	Wiley
開始ページ	e70396
ISSN	0031-9317
NCID	AA00774354
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2025 The Author(s).
論文のバージョン	publisher
PubMed ID	40635129
DOI	10.1111/ppl.70396
Web of Science KeyUT	001524789000001
関連URL	isVersionOf https://doi.org/10.1111/ppl.70396

Effect of Lipopolysaccharide on the Duration of Zolpidem-Induced Loss of Righting Reflex in Mice

JaLCDOI	10.18926/AMO/67197
フルテキストURL	78_3_227.pdf
著者	Wada, Yudai\| Ushio, Soichiro\| Kitamura, Yoshihisa\| Zamami, Yoshito\| Sendo, Toshiaki\|
抄録	Zolpidem, a non-benzodiazepine hypnotic, is primarily used to treat insomnia. In a previous study, pior treatment with non-benzodiazepine receptor agonists was associated with inflammation. The present study aimed to clarify the association between the effects of zolpidem and inflammation in mice treated with lipopolysaccharide (LPS), a known model of inflammation. We assessed the zolpidem-induced loss of righting reflex (LORR) duration 24 h after LPS treatment in mice. Additionally, the expressions of γ-aminobutyric acid (GABA)A receptor subunit and K+-Cl− cotransporter isoform 2 (KCC2) mRNA in the hippocampus and frontal cortex were examined in LPS-treated mice. Pretreatment with LPS was associated with significantly prolonged duration of zolpidem-induced LORR compared to control mice. This effect was significantly attenuated by administering bicuculline, a GABAA receptor antagonist, or flumazenil, a benzodiazepine receptor antagonist, in LPS-treated mice. Compared to controls, LPS-treated mice showed no significant change in the expression of GABAA receptor subunits in the hippocampus or frontal cortex. Bumetanide, an Na+-K+-2Cl− cotransporter isoform 1 blocker, attenuated the extended duration of zolpidem-induced LORR observed in LPS-treated mice. LPS significantly decreased Kcc2 mRNA expression in the hippocampus and the frontal cortex. These findings suggest that inflammation increases zolpidem-induced LORR, possibly through a reduction in KCC2 expression.
キーワード	lipopolysaccharide zolpidem GABAA receptor K+-Cl− cotransporters
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2024-06
巻	78巻
号	3号
出版者	Okayama University Medical School
開始ページ	227
終了ページ	235
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38902210
Web of Science KeyUT	001267351000003

Optical multi-context scrubbing operation on a redundant system

フルテキストURL	fulltext.pdf
著者	Ando, Kakeru\| Watanabe, Minoru\| Watanabe, Nobuya\|
備考	© 2023 Optica Publishing Group. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for non-commercial purposes and appropriate attribution is maintained. All other rights are reserved.\|
発行日	2023-11-06
出版物タイトル	Optics Express
巻	31巻
号	23号
出版者	Optica Publishing Group
開始ページ	38529
終了ページ	38539
ISSN	1094-4087
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement
論文のバージョン	publisher
PubMed ID	38017956
DOI	10.1364/OE.500666
Web of Science KeyUT	001108090500007
関連URL	isVersionOf https://doi.org/10.1364/OE.500666

Antimicrobials in the Hospital Are Unevenly Discontinued on Weekdays

フルテキストURL	fulltext.pdf
著者	Hagiya, Hideharu\| Uno, Mika\| Higashionna, Tsukasa\| Honda, Hiroyuki\| Otsuka, Fumio\|
キーワード	antimicrobial resistance antimicrobial stewardship antibiotics weekdays weekends
発行日	2023-06-15
出版物タイトル	Internal Medicine
巻	62巻
号	12号
出版者	Japanese Society of Internal Medicine
開始ページ	1739
終了ページ	1742
ISSN	0918-2918
NCID	AA10827774
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 by The Japanese Society of Internal Medicine
論文のバージョン	publisher
PubMed ID	36288987
DOI	10.2169/internalmedicine.0707-22
Web of Science KeyUT	001015018300001
関連URL	isVersionOf https://doi.org/10.2169/internalmedicine.0707-22

A blue-shifted anion channelrhodopsin from the Colpodellida alga Vitrella brassicaformis

フルテキストURL	fulltext.pdf
著者	Kojima, Keiichi\| Kawanishi, Shiho\| Nishimura, Yosuke\| Hasegawa, Masumi\| Nakao, Shin\| Nagata, Yuya\| Yoshizawa, Susumu\| Sudo, Yuki\|
備考	The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-34125-8\|
発行日	2023-04-28
出版物タイトル	Scientific Reports
巻	13巻
号	1号
出版者	nature portfolio
開始ページ	6974
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2023
論文のバージョン	publisher
PubMed ID	37117398
DOI	10.1038/s41598-023-34125-8
Web of Science KeyUT	000985908500047
関連URL	isVersionOf https://doi.org/10.1038/s41598-023-34125-8

Semiconductor-metal transition in Bi2Se3 caused by impurity doping

フルテキストURL	fulltext.pdf
著者	Uchiyama, Takaki\| Goto, Hidenori\| Uesugi, Eri\| Takai, Akihisa\| Zhi, Lei\| Miura, Akari\| Hamao, Shino\| Eguchi, Ritsuko\| Ota, Hiromi\| Sugimoto, Kunihisa\| Fujiwara, Akihiko\| Matsui, Fumihiko\| Kimura, Koji\| Hayashi, Kouichi\| Ueno, Teppei\| Kobayashi, Kaya\| Akimitsu, Jun\| Kubozono, Yoshihiro\|
備考	The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-27701-5\|
発行日	2023-01-11
出版物タイトル	Scientific Reports
巻	13巻
号	1号
出版者	nature portfolio
開始ページ	537
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2023
論文のバージョン	publisher
PubMed ID	36631625
DOI	10.1038/s41598-023-27701-5
Web of Science KeyUT	000986510100067
関連URL	isVersionOf https://doi.org/10.1038/s41598-023-27701-5

Patient-specific respiratory motion management using lung tumors vs fiducial markers for real-time tumor-tracking stereotactic body radiotherapy

フルテキストURL	fulltext.pdf
著者	Tanabe, Yoshinori\| Kiritani, Michiru\| Deguchi, Tomomi\| Hira, Nanami\| Tomimoto, Syouta\|
キーワード	Patient-specific respiratory motion management Stereotactic body radiotherapy Four-dimensional computed tomography Fiducial marker Lung cancer Gating window
発行日	2023-01
出版物タイトル	Physics and Imaging in Radiation Oncology
巻	25巻
出版者	Elsevier
開始ページ	100405
ISSN	2405-6316
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 The Author(s).
論文のバージョン	publisher
PubMed ID	36655212
DOI	10.1016/j.phro.2022.12.002
Web of Science KeyUT	000974743600001
関連URL	isVersionOf https://doi.org/10.1016/j.phro.2022.12.002

Statistical evaluation of the effectiveness of dual amplitude-gated stereotactic body radiotherapy using fiducial markers and lung volume

フルテキストURL	fulltext.pdf
著者	Tanabe, Yoshinori\| Tanaka, Hidekazu\|
キーワード	Fiducial marker Respiratory gating method Stereotactic body radiotherapy Tumor tracking Lung cancer 4DCT
発行日	2022-10-12
出版物タイトル	Physics and Imaging in Radiation Oncology
巻	24巻
出版者	Elsevier B.V.
開始ページ	82
終了ページ	87
ISSN	24056316
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 The Author(s).
論文のバージョン	publisher
PubMed ID	36267878
DOI	10.1016/j.phro.2022.10.001
Web of Science KeyUT	000876945200001
関連URL	isVersionOf https://doi.org/10.1016/j.phro.2022.10.001

Roles of the Flexible Primary Coordination Sphere of the Mn4CaOx Cluster: What Are the Immediate Decay Products of the S-3 State?

フルテキストURL	fulltext20221114-1.pdf
著者	Isobe, Hiroshi\| Shoji, Mitsuo\| Suzuki, Takayoshi\| Shen, Jian-Ren\| Yamaguchi, Kizashi\|
備考	This document is the Accepted Manuscript version of a Published Work that appeared in final form in The Journal of Physical Chemistry B, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.jpcb.2c02596\| This full-text will be available in Sep. 2023.\|
発行日	2022-09-15
出版物タイトル	The Journal of Physical Chemistry B
巻	126巻
号	38号
出版者	American Chemical Society (ACS)
開始ページ	7212
終了ページ	7228
ISSN	1520-6106
NCID	AA11114073
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 American Chemical Society
論文のバージョン	author
PubMed ID	36107406
DOI	10.1021/acs.jpcb.2c02596
Web of Science KeyUT	000863255500001
関連URL	isVersionOf https://doi.org/10.1021/acs.jpcb.2c02596

Current Insights into Mesenchymal Signatures in Glioblastoma

JaLCDOI	10.18926/AMO/64024
フルテキストURL	76_5_489.pdf
著者	Matsumoto, Yuji\| Ichikawa, Tomotsugu\| Kurozumi, Kazuhiko\| Date, Isao\|
抄録	Glioblastoma (GBM) is a fatal primary malignant brain tumor in adults. Despite decades of research, the prognosis for GBM patients is still disappointing. One major reason for the intense therapeutic resistance of GBM is inter- and intra-tumor heterogeneity. GBM-intrinsic transcriptional profiling has suggested the presence of at least three subtypes of GBM: the proneural, classic, and mesenchymal subtypes. The mesenchymal subtype is the most aggressive, and patients with the mesenchymal subtype of primary and recurrent tumors tend to have a worse prognosis compared with patients with the other subtypes. Furthermore, GBM can shift from other subtypes to the mesenchymal subtype over the course of disease progression or recurrence. This phenotypic transition is driven by diverse tumor-intrinsic molecular mechanisms or microenvironmental factors. Thus, better understanding of the plastic nature of mesenchymal transition in GBM is pivotal to developing new therapeutic strategies. In this review, we provide a comprehensive overview of the current understanding of the elements involved in the mesenchymal transition of GBM and discuss future perspectives.
キーワード	glioma glioblastoma mesenchymal subtype mesenchymal transition heterogeneity
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2022-10
巻	76巻
号	5号
出版者	Okayama University Medical School
開始ページ	489
終了ページ	502
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36352795
Web of Science KeyUT	000884907100001

5-Nitro-2-(3-phenylpropylamino) Benzoic Acid Inhibits the Proliferation and Migration of Lens Epithelial Cells by Blocking CaMKII Signaling

JaLCDOI	10.18926/AMO/63896
フルテキストURL	76_4_415.pdf
著者	Kang, Haijun\| Huang, Dongmei\| Kang, Gangjin\| Yang, Xu\| Li, Heng\| Liu, Siyuan\| Gou, Wenjun\| Liu, Linglin\| Qiu, Yuyan\|
抄録	Posterior capsule opacification (PCO) is a post-surgery complication of cataract surgery, and lens epithelial cells (LECs) are involved in its development. A suppressive effect on LECs is exerted by the non specific chloride channel inhibitor 5-nitro-2-(3-phenylpropylamino) benzoic acid (NPPB) exerts. Herein, the growth and migration inhibitory effects of NPPB on LECs were assessed, and the mechanism underlying the effects were investigated by focusing on Ca2+/CaMKII signaling. LECs were treated with different concentrations of NPPB, and the changes in cell viability, cell-cycle distribution, anchorage-dependent growth, migration, Ca2+ level, and CaMKII expression were evaluated. NPPB inhibited LECs’ proliferation and induced G1 cell-cycle arrest in the cells. Regarding LECs’ mobility, NPPB suppressed the cells’ anchorage-dependent growth ability and inhibited their migration. Changes in cell phenotypes were associated with an increased intracellular Ca2+ level and down-regulation of CaMKII. Together these results confirmed the inhibitory effect of NPPB on the proliferation and migration of LECs, and the effect was shown to be associated with the induced level of Ca2+ and the inhibition of CaMKII signaling transduction.
キーワード	5-nitro-2-(3-phenylpropylamino) benzoic acid CaMKII lens epithelial cell migration proliferation
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-08
巻	76巻
号	4号
出版者	Okayama University Medical School
開始ページ	415
終了ページ	421
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36123156
Web of Science KeyUT	000882167300007

Intrathecal Administration of the α1 Adrenergic Antagonist Phentolamine Upregulates Spinal GLT-1 and Improves Mirror Image Pain in SNI Model Rats

JaLCDOI	10.18926/AMO/63719
フルテキストURL	76_3_255.pdf
著者	Nakatsuka, Kosuke\| Matsuoka, Yoshikazu\| Kurita, Masako\| Wang, Ruilin\| Tsuboi, Chika\| Sue, Nobutaka\| Kaku, Ryuji\| Morimatsu, Hiroshi\|
抄録	Mirror image pain (MIP) is a type of extraterritorial pain that results in contralateral pain or allodynia. Glutamate transporter-1 (GLT-1) is expressed in astrocytes and plays a role in maintaining low glutamate levels in the synaptic cleft. Previous studies have shown that GLT-1 dysfunction induces neuropathic pain. Our previous study revealed bilateral GLT-1 downregulation in the spinal cord of a spared nerve injury (SNI) rat. We hypothesized that spinal GLT-1 is involved in the mechanism of MIP. We also previously demonstrated noradrenergic GLT-1 regulation. Therefore, this study aimed to investigate the effect of an α1 adrenergic antagonist on the development of MIP. Rats were subjected to SNI. Changes in pain behavior and GLT-1 protein levels in the SNI rat spinal cords were then examined by intrathecal administration of the α1 adrenergic antagonist phentolamine, followed by von Frey test and western blotting. SNI resulted in the development of MIP and bilateral downregulation of GLT-1 protein in the rat spinal cord. Intrathecal phentolamine increased contralateral GLT-1 protein levels and partially ameliorated the 50% paw withdrawal threshold in the contralateral hind paw. Spinal GLT-1 upregulation by intrathecal phentolamine ameliorates MIP. GLT-1 plays a role in the development of MIPs.
キーワード	alpha adrenergic receptor glutamate transporter-1 mirror image pain neuropathic pain spared nerve injury
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-06
巻	76巻
号	3号
出版者	Okayama University Medical School
開始ページ	255
終了ページ	263
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35790355
Web of Science KeyUT	000823568300004

Enhancement of pacing function by HCN4 overexpression in human pluripotent stem cell-derived cardiomyocytes

フルテキストURL	fulltext.pdf
著者	Saito, Yukihiro\| Nakamura, Kazufumi\| Yoshida, Masashi\| Sugiyama, Hiroki\| Akagi, Satoshi\| Miyoshi, Toru\| Morita, Hiroshi\| Ito, Hiroshi\|
キーワード	Hyperpolarization-activated cyclic nucleotide-gated potassium channel 4 Human induced pluripotent stem cell-derived cardiomyocytes Pacing
発行日	2022-04-01
出版物タイトル	STEM Cell Research & Therapy
巻	13巻
号	1号
出版者	BMC
開始ページ	141
ISSN	1757-6512
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2022.
論文のバージョン	publisher
PubMed ID	35365232
DOI	10.1186/s13287-022-02818-y
Web of Science KeyUT	000778298400007
関連URL	isVersionOf https://doi.org/10.1186/s13287-022-02818-y