start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=
article-no=
start-page=52641
end-page=52653
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2026
dt-pub=2026
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Programmable Clock Distribution Using Switching Matrices for Field Programmable Gate Arrays
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Every digital systems using very large scale integration require clock distributions, for which a dedicated clock tree or a mesh clock is frequently used. Field programmable gate arrays have numerous general-purpose programmable wires based on switching matrices to connect the outputs and inputs of look-up tables and input–output ports. However, field programmable gate arrays never use numerous general-purpose programmable wires for their clock distributions to satisfy the clock skew margin similarly to very large scale integrations. Field programmable gate arrays also use dedicated clock trees, although their programmability is not high. Currently, field programmable gate arrays can support multiple dedicated clock routing or multiple clock trees. Unfortunately, the number of clock trees is fixed. They remain limited to a small number. Even if an application requires many clock distributions, such a clock distribution cannot be supported in current field programmable gate arrays. This paper therefore presents a proposal of a more flexible clock distribution method based on wiring channels and switching matrices. The method uses general-purpose programmable wires. In addition, to resolve clock skew increase difficulties, we have introduced a new flip-flop with a two-phase clock signal. This paper presents simulation results obtained using the proposed clock distribution method on an originally designed field programmable gate array. In addition, experimentally obtained results indicate that the proposed clock distribution method can function correctly on a Cyclone V field programmable gate array.
en-copyright=
kn-copyright=

en-aut-name=OguraAyumu
en-aut-sei=Ogura
en-aut-mei=Ayumu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=WatanabeMinoru
en-aut-sei=Watanabe
en-aut-mei=Minoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WatanabeNobuya
en-aut-sei=Watanabe
en-aut-mei=Nobuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Okayama University
kn-affil=

affil-num=2
en-affil=Okayama University
kn-affil=

affil-num=3
en-affil=Okayama University
kn-affil=
en-keyword=Clock distribution
kn-keyword=Clock distribution
en-keyword=field programmable gate array (FPGA)
kn-keyword=field programmable gate array (FPGA)
en-keyword=programmable device
kn-keyword=programmable device
en-keyword=two-phase clock
kn-keyword=two-phase clock
END

start-ver=1.4
cd-journal=joma
no-vol=8
cd-vols=
no-issue=
article-no=
start-page=1759690
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2026
dt-pub=20260309
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Development of a generative AI agent for family support in implementing family-based treatment for children and adolescents with anorexia nervosa
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Introduction: Family-based treatment (FBT) is a first-line psychotherapy for children and adolescents with anorexia nervosa (AN). However, families must understand the principles of FBT, provide meal support, and manage their children's pathological behaviors. Difficulties occur outside clinic hours when it is impossible to consult professionals. This “support gap” increases caregivers’ psychological distress and threatens their treatment continuity. To the best of our knowledge, this is the first domain-specific generative artificial intelligence (AI) agent designed to provide situation-specific, FBT-concordant advice and psychological support.<br>
Methods: The system integrates three components: (1) an FBT-specific knowledge base constructed from treatment manuals, family guides, guideline-compliant resources, and a clinical Q&A corpus; (2) a multistage natural language processing pipeline using Retrieval-Augmented Generation (RAG), with intent and sentiment analyses; and (3) safety guardrails that prohibit unsolicited numerical goals or direct hospitalization recommendations and standardized escalation to clinicians. When strong negative emotions are detected, empowerment messages are dynamically incorporated to maintain caregivers’ confidence. Six clinicians with expertise with pediatric mental health authored queries that simulated common FBT-related concerns and evaluated each response for clinical appropriateness and safety, and classified problems as information insufficiency, not FBT concordant, or escalation insufficiency.<br>
Results: Of the 477 queries, 57.0% were FBT-related, 24.5% were general AN, 16.5% were parental psychological distress, and 1.8% were related to other topics. The clinically appropriate response rate was 91.6% (437/477), including 92.3% for FBT-related questions, 88.0% for general knowledge, 93.7% for psychological distress, and 100.0% for other questions. Clinically inappropriate responses (8.4%) were mainly attributable to information insufficiency; not FBT concordant (1.8% of FBT-related responses) and escalation insufficiency (0.6% of all dialogs) rarely occurred.<br>
Discussion: In this expert review, the safety-gated RAG system predominantly generated FBT-concordant responses that provided meal-level guidance and empathic empowerment-oriented support to families. By proceduralizing complex FBT concepts and presenting multiple response options for pathological behaviors, the system translates FBT principles into practical guidance supporting refeeding adherence, preserving family self-efficacy, and suggesting that domain-specific AI may help bridge structural limitations in FBT. Usability studies and randomized controlled trials are warranted to determine their impact on caregiver burden, self-efficacy, treatment adherence, and clinical outcomes.
en-copyright=
kn-copyright=

en-aut-name=HanzawaMana
en-aut-sei=Hanzawa
en-aut-mei=Mana
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HaseiJoe
en-aut-sei=Hasei
en-aut-mei=Joe
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OkadaAyumi
en-aut-sei=Okada
en-aut-mei=Ayumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TanakaChie
en-aut-sei=Tanaka
en-aut-mei=Chie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ShigeyasuYoshie
en-aut-sei=Shigeyasu
en-aut-mei=Yoshie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=FujiiChikako
en-aut-sei=Fujii
en-aut-mei=Chikako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=HoriuchiMakiko
en-aut-sei=Horiuchi
en-aut-mei=Makiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=SugiharaAkiko
en-aut-sei=Sugihara
en-aut-mei=Akiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=TakeuchiKoichi
en-aut-sei=Takeuchi
en-aut-mei=Koichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=NakaharaRyuichi
en-aut-sei=Nakahara
en-aut-mei=Ryuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=KatayamaHideki
en-aut-sei=Katayama
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=TakahashiYasushi
en-aut-sei=Takahashi
en-aut-mei=Yasushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=TsukaharaHirokazu
en-aut-sei=Tsukahara
en-aut-mei=Hirokazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

affil-num=1
en-affil=Department of Pediatrics, Okayama University Hospital Medical Center for Children
kn-affil=

affil-num=2
en-affil=Department of Medical Informatics and Clinical Support Technology Development, Faculty of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Pediatrics, Okayama University Hospital Medical Center for Children
kn-affil=

affil-num=4
en-affil=Department of Pediatrics, Okayama University Hospital Medical Center for Children
kn-affil=

affil-num=5
en-affil=Department of Pediatrics, Okayama University Hospital Medical Center for Children
kn-affil=

affil-num=6
en-affil=Department of Pediatrics, Okayama University Hospital Medical Center for Children
kn-affil=

affil-num=7
en-affil=Clinical Psychology Section, Department of Medical Support, Okayama University Hospital
kn-affil=

affil-num=8
en-affil=Department of Pediatrics, Okayama University Hospital Medical Center for Children
kn-affil=

affil-num=9
en-affil=Life Natural Science and Technology, Graduate School of Environmental, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Musculoskeletal Health Promotion, Faculty of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Department of Palliative and Supportive Care, Okayama University Hospital
kn-affil=

affil-num=12
en-affil=NEC Corporation
kn-affil=

affil-num=13
en-affil=Department of Orthopaedic Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=14
en-affil=Department of Pediatrics, Okayama University Hospital Medical Center for Children
kn-affil=
en-keyword=anorexia nervosa
kn-keyword=anorexia nervosa
en-keyword=caregiver burden
kn-keyword=caregiver burden
en-keyword=family support
kn-keyword=family support
en-keyword=family-based treatment
kn-keyword=family-based treatment
en-keyword=generative AI agent
kn-keyword=generative AI agent
en-keyword=large language model
kn-keyword=large language model
en-keyword=retrieval-augmented generation
kn-keyword=retrieval-augmented generation
END

start-ver=1.4
cd-journal=joma
no-vol=60
cd-vols=
no-issue=
article-no=
start-page=(21)
end-page=(39)
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20251210
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=On Ten-nyo (Heavenly Maidens) with Wings, Part 13: The Ceiling of the Main Gate of the Higashi Hongan-ji Temple by Takeuchi Seiho and its Surroundings
kn-title=「有翼の天女図」十三考― 竹内栖鳳による東本願寺御影堂門の天井画とその周辺 ―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TATSUNOYuko
en-aut-sei=TATSUNO
en-aut-mei=Yuko
kn-aut-name=龍野　有子
kn-aut-sei=龍野　
kn-aut-mei=有子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学学術研究院社会文化科学学域
END

start-ver=1.4
cd-journal=joma
no-vol=17
cd-vols=
no-issue=10
article-no=
start-page=e94951
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20251019
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Bladder Trigone as a Sensory Hub: A Narrative Review
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The bladder trigone is an anatomically and functionally distinct region within the lower urinary tract (LUT), characterized by a dense network of afferent sensory fibers, specialized urothelial interactions, and prominent mechanotransduction mechanisms. Its intricate neuroarchitecture enables precise detection of bladder filling and coordination of micturition, whereas dysregulation of these pathways contributes to lower urinary tract symptoms (LUTS), including urgency, frequency, and bladder pain. Despite its recognized clinical relevance, the structural and functional basis of trigonal sensory signaling - and its role - remain incompletely understood.<br>
This review synthesizes current evidence on trigonal afferent organization, integrating data from anatomical mapping, receptor profiling, electrophysiological characterization, and translational research. Seminal anatomical observations are combined with recent advances in mechanotransduction and purinergic, peptidergic, and transient receptor potential (TRP) signaling to provide a comprehensive perspective. The trigone exhibits three principal afferent classes: (1) intraepithelial fibers penetrating umbrella cells, marked by P2X purinoceptor 3 (P2X3), transient receptor potential vanilloid 1 (TRPV1), calcitonin gene-related peptide (CGRP), and substance P (SP); (2) subepithelial plexuses surrounding microvasculature, enriched in vasoactive neuropeptides and exhibiting plastic hypertrophy in overactive bladder (OAB) and interstitial cystitis/bladder pain syndrome (IC/BPS); and (3) encapsulated corpuscular endings at the lamina propria-detrusor junction, expressing PIEZO1/2 and acid-sensing ion channels (ASICs) for rapid adaptation. In trigeminal dorsal root ganglion (DRG) neurons, high expression of PIEZO2, P2RX3, and voltage-gated sodium channel, type 1.8 (Nav1.8) was observed, revealing their role as the foundation for multisensory information processing. Functional assays highlight distinct mechanotransductive and chemosensory pathways, with aging, inflammation, and neurotrophic factors driving afferent plasticity underlying abnormal bladder sensation, such as urgency, frequency, and pain. Early clinical trials of P2X3 antagonists and intravesical TRPV1 inhibitors demonstrate promising symptomatic benefits. Collectively, evidence positions the bladder trigone as a critical sensory hub where neuronal, urothelial, and immune signals converge to regulate bladder sensation. Understanding its molecular and structural specialization may inform the development of region-specific neuromodulatory therapies targeting sensory urgency and afferent-driven bladder dysfunction.
en-copyright=
kn-copyright=

en-aut-name=SadahiraTakuya
en-aut-sei=Sadahira
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MaruyamaYuki
en-aut-sei=Maruyama
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MitsuiYosuke
en-aut-sei=Mitsui
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SekitoTakanori
en-aut-sei=Sekito
en-aut-mei=Takanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=WatanabeTomofumi
en-aut-sei=Watanabe
en-aut-mei=Tomofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=WatanabeMasami
en-aut-sei=Watanabe
en-aut-mei=Masami
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=bladder trigone
kn-keyword=bladder trigone
en-keyword=botulinum toxin
kn-keyword=botulinum toxin
en-keyword=lower urinary tract symptoms
kn-keyword=lower urinary tract symptoms
en-keyword=sensory afferents
kn-keyword=sensory afferents
en-keyword=varicosities
kn-keyword=varicosities
END

start-ver=1.4
cd-journal=joma
no-vol=79
cd-vols=
no-issue=5
article-no=
start-page=369
end-page=379
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=202510
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Blood Pressure and Heart Rate Patterns Identified by Unsupervised Machine Learning and Their Associations with Subclinical Cerebral and Renal Damage in a Japanese Community: The Masuda Study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We applied unsupervised machine learning to analyze blood pressure (BP) and resting heart rate (HR) patterns measured during a 1-year period to assess their cross-sectional relationships with subclinical cerebral and renal target damage. Dimension reduction via uniform manifold approximation and projection, followed by K-means++ clustering, was used to categorize 362 community-dwelling participants (mean age, 56.2 years; 54.9% women) into three groups: Low BP and Low HR (Lo-BP/Lo-HR), High BP and High HR (Hi-BP/Hi-HR), and Low BP and High HR (Lo-BP/Hi-HR). Cerebral vessel lesions were defined as the presence of at least one of the following magnetic resonance imaging findings: lacunar infarcts, white matter hyperintensities, cerebral microbleeds, or intracranial artery stenosis. A high urinary albumin-to-creatinine ratio (UACR) was defined as the top 10% (≥ 12 mg/g) of the mean value from ≥2 measurements. Poisson regression with robust error variance, adjusted for demographics, lifestyle, and medical history, showed that the Hi-BP/Hi-HR group had relative risks of 3.62 (95% confidence interval, 1.75-7.46) for cerebral vessel lesions and 3.58 (1.33-9.67) for high UACR, and the Lo-BP/Hi-HR group had a relative risk of 3.09 (1.12-8.57) for high UACR, compared with the Lo-BP/Lo-HR group. These findings demonstrate the utility of an unsupervised, data-driven approach for identifying physiological patterns associated with subclinical target organ damage.
en-copyright=
kn-copyright=

en-aut-name=HisamatsuTakashi
en-aut-sei=Hisamatsu
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KinutaMinako
en-aut-sei=Kinuta
en-aut-mei=Minako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MunetomoSosuke
en-aut-sei=Munetomo
en-aut-mei=Sosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=FukudaMari
en-aut-sei=Fukuda
en-aut-mei=Mari
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KojimaKatsuhide
en-aut-sei=Kojima
en-aut-mei=Katsuhide
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TaniguchiKaori
en-aut-sei=Taniguchi
en-aut-mei=Kaori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NakahataNoriko
en-aut-sei=Nakahata
en-aut-mei=Noriko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KandaHideyuki
en-aut-sei=Kanda
en-aut-mei=Hideyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Environmental Medicine and Public Health, Izumo, Shimane University Faculty of Medicine
kn-affil=

affil-num=7
en-affil=Department of Health and Nutrition, The University of Shimane Faculty of Nursing and Nutrition
kn-affil=

affil-num=8
en-affil=Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=blood pressure
kn-keyword=blood pressure
en-keyword=heart rate
kn-keyword=heart rate
en-keyword=subclinical disease
kn-keyword=subclinical disease
en-keyword=uniform manifold approximation and projection
kn-keyword=uniform manifold approximation and projection
en-keyword=unsupervised machine learning
kn-keyword=unsupervised machine learning
END

start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=
article-no=
start-page=89003
end-page=89024
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250519
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Security in Post-Quantum Era: A Comprehensive Survey on Lattice-Based Algorithms
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Lattice-based post-quantum cryptography (PQC) has attracted significant attention as a promising solution to the security challenges posed by quantum computing. Unlike traditional cryptographic algorithms, lattice-based schemes are expected to remain secure even in the presence of quantum attacks, making them essential for securing future data. Despite their strong theoretical foundations, lattice-based schemes face several practical challenges, particularly in optimizing performance and scalability for real-world applications. This survey provides a novel taxonomy that categorizes lattice-based PQC designs, with an emphasis on computational paradigms and security considerations. We systematically evaluate lattice-based PQC implementations across both software platforms, including central processing units and graphics processing units, as well as hardware platforms like field-programmable gate arrays and application-specific integrated circuits, highlighting their strengths and limitations. In addition, we explore the practical applications of lattice-based cryptography in fields such as secure communication, critical infrastructure, privacy-preserving data analytics, artificial intelligence, and trust and authentication systems. By offering a comprehensive overview of the current state of lattice-based PQC, this survey aims to provide valuable insights into the ongoing advancements and future research directions in the field as we transition to a post-quantum era.
en-copyright=
kn-copyright=

en-aut-name=NguyenHien
en-aut-sei=Nguyen
en-aut-mei=Hien
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HudaSamsul
en-aut-sei=Huda
en-aut-mei=Samsul
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NogamiYasuyuki
en-aut-sei=Nogami
en-aut-mei=Yasuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NguyenTuy Tan
en-aut-sei=Nguyen
en-aut-mei=Tuy Tan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=School of Informatics, Computing, and Cyber Systems, Northern Arizona University
kn-affil=

affil-num=2
en-affil=Interdisciplinary Education and Research Field, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=School of Informatics, Computing, and Cyber Systems, Northern Arizona University
kn-affil=
en-keyword=Post-quantum cryptography
kn-keyword=Post-quantum cryptography
en-keyword=lattice-based cryptography
kn-keyword=lattice-based cryptography
en-keyword=number theoretic transform
kn-keyword=number theoretic transform
en-keyword=hardware and software implementation
kn-keyword=hardware and software implementation
END

start-ver=1.4
cd-journal=joma
no-vol=52
cd-vols=
no-issue=8
article-no=
start-page=e18026
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=202508
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Commissioning of respiratory‐gated 4D dynamic dose calculations for various gating widths without spot timestamp in proton pencil beam scanning
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: Proton pencil beam scanning (PBS) is susceptible to dose degradation because of interplay effects on moving targets. For cases of unacceptable motion, respiratory-gated (RG) irradiation is an effective alternative to free breathing (FB) irradiation. However, the introduction of RG irradiation with larger gate widths (GW) is hindered by interplay effects, which are analogous to those observed with FB irradiation. Accurate estimation of interplay effects can be performed by recording spot timestamps. However, our machine lacks this feature, making it imperative to find an alternative approach. Thus, we developed an RG 4-dimensional dynamic dose (RG-4DDD) system without spot timestamps.<br>
Purpose: This study aimed to investigate the accuracy of calculated doses from the RG-4DDD system for PBS plans with varying breathing curves, amplitudes, and periods for 10%–50% GW.<br>
Methods: RG-4DDDs were reconstructed using in-house developed software that assigned timestamps to individual spots, integrated start times for spills with breathing curves, and utilized deformable registrations for dose accumulation. Three cubic verification plans were created using a heterogeneous phantom. Additionally, typical liver and lung cases were employed for patient plan validation. Single- and multi-field-optimized (SFO and IMPT) plans (ten beams in total) were created for the liver and lung cases in a homogeneous phantom. Lateral profile measurements were obtained under both motion and no-motion conditions using a 2D ionization chamber array (2D-array) and EBT3 Gafchromic films on the CIRS dynamic platform. Breathing curves from the cubic plans were used to assess nine patterns of sine curves, with amplitudes of 5.0–10.0 mm (10.0–20.0 mm target motions) and periods of 3–6 sec. Patient field verifications were conducted using a representative patient curve with an average amplitude of 6.4 mm and period of 3.2 sec. Additional simulations were performed assuming a ± 10% change in assigned timestamps for the dose rate (DR), spot spill (0.08-s), and gate time delay (0.1-s) to evaluate the effect of parameter selection on our 4DDD models. The 4DDDs were compared with measured values using the 2D gamma index and absolute doses over that required for dosing 95% of the target.<br>
Results: The 2D-array measurements showed that average gamma scores for the reference (no motion) and 4DDD plans for all GWs were at least 99.9 ± 0.2% and 98.2 ± 2.4% at 3%/3 mm, respectively. The gamma scores of the 4DDDs in film measurements exceeded 95.4% and 92.9% at 2%/2 mm for the cubic and patient plans, respectively. The 4DDD calculations were acceptable under DR changes of ±10% and both spill and gate time delays of ±0.18 sec. For the 4DDD plan using all GWs for all measurement points, the absolute point differences for all validation plans were within ±5.0% for 99.1% of the points.<br>
Conclusions: The RG-4DDD calculations (less than 50% GW) of the heterogeneous and actual patient plans showed good agreement with measurements for various breathing curves in the amplitudes and periods described above. The proposed system allows us to evaluate actual RG irradiation without requiring the ability to record spot timestamps.
en-copyright=
kn-copyright=

en-aut-name=TominagaYuki
en-aut-sei=Tominaga
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=WakisakaYushi
en-aut-sei=Wakisaka
en-aut-mei=Yushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KatoTakahiro
en-aut-sei=Kato
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=IchiharaMasaya
en-aut-sei=Ichihara
en-aut-mei=Masaya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YasuiKeisuke
en-aut-sei=Yasui
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SasakiMotoharu
en-aut-sei=Sasaki
en-aut-mei=Motoharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=OitaMasataka
en-aut-sei=Oita
en-aut-mei=Masataka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=NishioTeiji
en-aut-sei=Nishio
en-aut-mei=Teiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Radiotherapy, Medical Co. Hakuhokai, Osaka Proton Therapy Clinic
kn-affil=

affil-num=2
en-affil=Department of Radiotherapy, Medical Co. Hakuhokai, Osaka Proton Therapy Clinic
kn-affil=

affil-num=3
en-affil=Department of Radiological Sciences, School of Health Sciences, Fukushima Medical University
kn-affil=

affil-num=4
en-affil=Medical Physics Laboratory, Division of Health Science, Graduate School of Medicine, The University of Osaka
kn-affil=

affil-num=5
en-affil=School of Medical Sciences, Fujita Health University
kn-affil=

affil-num=6
en-affil=Graduate School of Biomedical Sciences, Tokushima University
kn-affil=

affil-num=7
en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=8
en-affil=Medical Physics Laboratory, Division of Health Science, Graduate School of Medicine, The University of Osaka
kn-affil=
en-keyword=4D dynamic dose
kn-keyword=4D dynamic dose
en-keyword=interplay effect
kn-keyword=interplay effect
en-keyword=pencil beam scanning
kn-keyword=pencil beam scanning
en-keyword=proton therapy
kn-keyword=proton therapy
en-keyword=respiratory gating
kn-keyword=respiratory gating
END

start-ver=1.4
cd-journal=joma
no-vol=177
cd-vols=
no-issue=4
article-no=
start-page=e70396
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=202507
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=CNGC2 Negatively Regulates Stomatal Closure and Is Not Required for flg22- and H2O2-Induced Guard Cell [Ca2+]cyt Elevation in Arabidopsis thaliana
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In guard cells, cytosolic Ca2+ acts as a second messenger that mediates abscisic acid (ABA)- and pathogen-associated molecular pattern (PAMP)-induced stomatal closure. It was reported that Arabidopsis cyclic nucleotide-gated ion channel 2 (CNGC2) functions as hydrogen peroxide (H2O2)- and PAMP-activated Ca2+-permeable channels at the plasma membrane of mesophyll cells and mediates Ca2+-dependent PAMP-triggered immunity. In this study, we examined the role of CNGC2 in the regulation of stomatal movement because CNGC2 is also expressed in guard cells. We found that stomata of the CNGC2 disruption mutant cngc2-3 are constitutively closed even in the absence of ABA or the flagellar-derived PAMP, flg22. Consistently, leaf temperatures of the cngc2-3 mutant were higher than those of wild-type (WT) plants. The stomatal phenotype of the cngc2-3 mutant was restored by complementation with wild-type CNGC2 under the control of the guard cell preferential promoter, pGC1. Elevation of cytosolic free Ca2+ concentration in guard cells induced by flg22 and H2O2 remained intact in the cngc2-3 mutant. The introduction of the ost1-3 mutation into the cngc2-3 background did not alter the stomatal phenotype. However, the stomatal phenotype of the cngc2-3 mutant was successfully rescued in the double disruption mutant cngc2-3aba2-2. Taken together, these results suggest that CNGC2 negatively regulates stomatal closure response and does not function as flg22– and H2O2-activated Ca2+ channels in guard cells. Though CNGC2 is responsive for H2O2- and flg22-induced [Ca2+]cyt elevation in mesophyll cells, the involvement of CNGC2 in the response to H2O2 and flg22 in guard cells is questionable.
en-copyright=
kn-copyright=

en-aut-name=AkterRojina
en-aut-sei=Akter
en-aut-mei=Rojina
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=InoueYasuhiro
en-aut-sei=Inoue
en-aut-mei=Yasuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MasumotoSaori
en-aut-sei=Masumoto
en-aut-mei=Saori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MimataYoshiharu
en-aut-sei=Mimata
en-aut-mei=Yoshiharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MatsuuraTakakazu
en-aut-sei=Matsuura
en-aut-mei=Takakazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MoriIzumi C.
en-aut-sei=Mori
en-aut-mei=Izumi C.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NakamuraToshiyuki
en-aut-sei=Nakamura
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=NakamuraYoshimasa
en-aut-sei=Nakamura
en-aut-mei=Yoshimasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MurataYoshiyuki
en-aut-sei=Murata
en-aut-mei=Yoshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=MunemasaShintaro
en-aut-sei=Munemasa
en-aut-mei=Shintaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Faculty of Agriculture, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=5
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=6
en-affil=
kn-affil=

affil-num=7
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=8
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=9
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=10
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=calcium signaling
kn-keyword=calcium signaling
en-keyword=CNGC
kn-keyword=CNGC
en-keyword=stomata
kn-keyword=stomata
END

start-ver=1.4
cd-journal=joma
no-vol=78
cd-vols=
no-issue=3
article-no=
start-page=227
end-page=235
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202406
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effect of Lipopolysaccharide on the Duration of Zolpidem-Induced Loss of Righting Reflex in Mice
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Zolpidem, a non-benzodiazepine hypnotic, is primarily used to treat insomnia. In a previous study, pior treatment with non-benzodiazepine receptor agonists was associated with inflammation. The present study aimed to clarify the association between the effects of zolpidem and inflammation in mice treated with lipopolysaccharide (LPS), a known model of inflammation. We assessed the zolpidem-induced loss of righting reflex (LORR) duration 24 h after LPS treatment in mice. Additionally, the expressions of γ-aminobutyric acid (GABA)A receptor subunit and K+-Cl− cotransporter isoform 2 (KCC2) mRNA in the hippocampus and frontal cortex were examined in LPS-treated mice. Pretreatment with LPS was associated with significantly prolonged duration of zolpidem-induced LORR compared to control mice. This effect was significantly attenuated by administering bicuculline, a GABAA receptor antagonist, or flumazenil, a benzodiazepine receptor antagonist, in LPS-treated mice. Compared to controls, LPS-treated mice showed no significant change in the expression of GABAA receptor subunits in the hippocampus or frontal cortex. Bumetanide, an Na+-K+-2Cl− cotransporter isoform 1 blocker, attenuated the extended duration of zolpidem-induced LORR observed in LPS-treated mice. LPS significantly decreased Kcc2 mRNA expression in the hippocampus and the frontal cortex. These findings suggest that inflammation increases zolpidem-induced LORR, possibly through a reduction in KCC2 expression.
en-copyright=
kn-copyright=

en-aut-name=WadaYudai
en-aut-sei=Wada
en-aut-mei=Yudai
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=UshioSoichiro
en-aut-sei=Ushio
en-aut-mei=Soichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KitamuraYoshihisa
en-aut-sei=Kitamura
en-aut-mei=Yoshihisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ZamamiYoshito
en-aut-sei=Zamami
en-aut-mei=Yoshito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SendoToshiaki
en-aut-sei=Sendo
en-aut-mei=Toshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Clinical Pharmacy, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Pharmacy, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Clinical Pharmacy, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Clinical Pharmacy, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Clinical Pharmacy, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=lipopolysaccharide
kn-keyword=lipopolysaccharide
en-keyword=zolpidem
kn-keyword=zolpidem
en-keyword=GABAA receptor
kn-keyword=GABAA receptor
en-keyword=K+-Cl− cotransporters
kn-keyword=K+-Cl− cotransporters
END

start-ver=1.4
cd-journal=joma
no-vol=31
cd-vols=
no-issue=23
article-no=
start-page=38529
end-page=38539
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20231106
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Optical multi-context scrubbing operation on a redundant system
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This paper presents a proposal of the world-first optical multi-context scrubbing operation on a redundant system that can maintain the state of a sequential circuit and the operation continuously without any interruption on a radiation-hardened optically reconfigurable gate array even after a permanent failure suddenly happens on the sequential circuit or a flip-flop by radiation. Up to now, a high-speed optical scrubbing operation has been demonstrated on a radiation-hardened optically reconfigurable gate array. In addition, a multi-context scrubbing operation based on the high-speed optical scrubbing operation has already been demonstrated. Although the multi-context scrubbing operation presents the benefit that it can treat both soft errors and permanent failures caused by radiation simultaneously, the conventional contributions have never presented how to maintain the state of a sequential circuit after a permanent failure occurs on flip-flops. Therefore, in the conventional multi-context scrubbing operation, all the operations must be restarted from the initial condition each time a permanent failure occurs on a programmable gate array. As a result, conventional multi-context scrubbing operations could not be applied for real-time systems. The proposed optical multi-context scrubbing method that can solve the issue has been experimentally evaluated on a radiation-hardened optically reconfigurable gate array.
en-copyright=
kn-copyright=

en-aut-name=AndoKakeru
en-aut-sei=Ando
en-aut-mei=Kakeru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=WatanabeMinoru
en-aut-sei=Watanabe
en-aut-mei=Minoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WatanabeNobuya
en-aut-sei=Watanabe
en-aut-mei=Nobuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=62
cd-vols=
no-issue=12
article-no=
start-page=1739
end-page=1742
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230615
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Antimicrobials in the Hospital Are Unevenly Discontinued on Weekdays
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Objective　Amid the global spread of antimicrobial resistance, antimicrobial stewardship should be further promoted in the clinical setting. Our previous study suggested an intra-week disproportion of discontinuation of broad-spectrum antibiotics. We therefore explored the generalization of this prescription trend by investi-gating the use of all intravenous antibiotics.<br>
Methods　A retrospective, observational study.<br>
Patients　Between January 1, 2018, and December 31, 2020, we collected data on the initiation and discon-tinuation of intravenous antimicrobials on each day of the week and on days after holidays at Okayama Uni-versity Hospital, Japan. We compared the monthly antimicrobial prescription initiation and discontinuation using the Kruskal-Wallis test and Mann-Whitney U-test with Bonferroni correction as a post-hoc procedure.<br>
Results　Data from 15,293 hospitalized cases were analyzed. The initiation of antimicrobials differed slightly among days of the week, although this trend was clinically insignificant. Compared with the initia-tions, antimicrobial discontinuations were disproportionately biased among the weekdays, tending to occur on Mondays (p<0.001) about twice as often as on other days. Similarly, antimicrobials were unevenly discontin-ued on the day after holidays compared to other days (p<0.001), with an approximately 2-fold difference. The use of antimicrobials in the hospital was thus unequally terminated on weekdays.<br>
Conclusion　To further promote antimicrobial stewardship, clinicians should be aware of the influence of behavioral, environmental, and social factors on antimicrobial prescription, which is seemingly beyond medi-cal indications.
en-copyright=
kn-copyright=

en-aut-name=HagiyaHideharu
en-aut-sei=Hagiya
en-aut-mei=Hideharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=UnoMika
en-aut-sei=Uno
en-aut-mei=Mika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HigashionnaTsukasa
en-aut-sei=Higashionna
en-aut-mei=Tsukasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HondaHiroyuki
en-aut-sei=Honda
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OtsukaFumio
en-aut-sei=Otsuka
en-aut-mei=Fumio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Pharmacy, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=antimicrobial resistance
kn-keyword=antimicrobial resistance
en-keyword=antimicrobial stewardship
kn-keyword=antimicrobial stewardship
en-keyword=antibiotics
kn-keyword=antibiotics
en-keyword=weekdays
kn-keyword=weekdays
en-keyword=weekends
kn-keyword=weekends
END

start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=1
article-no=
start-page=6974
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230428
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A blue-shifted anion channelrhodopsin from the Colpodellida alga Vitrella brassicaformis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Microbial rhodopsins, a family of photoreceptive membrane proteins containing the chromophore retinal, show a variety of light-dependent molecular functions. Channelrhodopsins work as light-gated ion channels and are widely utilized for optogenetics, which is a method for controlling neural activities by light. Since two cation channelrhodopsins were identified from the chlorophyte alga Chlamydomonas reinhardtii, recent advances in genomic research have revealed a wide variety of channelrhodopsins including anion channelrhodopsins (ACRs), describing their highly diversified molecular properties (e.g., spectral sensitivity, kinetics and ion selectivity). Here, we report two channelrhodopsin-like rhodopsins from the Colpodellida alga Vitrella brassicaformis, which are phylogenetically distinct from the known channelrhodopsins. Spectroscopic and electrophysiological analyses indicated that these rhodopsins are green- and blue-sensitive pigments (lambda(max) = similar to 550 and similar to 440 nm) that exhibit light-dependent ion channeling activities. Detailed electrophysiological analysis revealed that one of them works as a monovalent anion (Cl-, Br- and NO3-) channel and we named it V. brassicaformis anion channelrhodopsin-2, VbACR2. Importantly, the absorption maximum of VbACR2 (similar to 440 nm) is blue-shifted among the known ACRs. Thus, we identified the new blue-shifted ACR, which leads to the expansion of the molecular diversity of ACRs.
en-copyright=
kn-copyright=

en-aut-name=KojimaKeiichi
en-aut-sei=Kojima
en-aut-mei=Keiichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KawanishiShiho
en-aut-sei=Kawanishi
en-aut-mei=Shiho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NishimuraYosuke
en-aut-sei=Nishimura
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HasegawaMasumi
en-aut-sei=Hasegawa
en-aut-mei=Masumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakaoShin
en-aut-sei=Nakao
en-aut-mei=Shin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NagataYuya
en-aut-sei=Nagata
en-aut-mei=Yuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YoshizawaSusumu
en-aut-sei=Yoshizawa
en-aut-mei=Susumu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=SudoYuki
en-aut-sei=Sudo
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Research Center for Bioscience and Nanoscience (CeBN), Research Institute for  Marine Resources Utilization, Japan Agency for Marine-Earth Science and Technology (JAMSTEC)
kn-affil=

affil-num=4
en-affil=Institute for Extra‑Cutting‑Edge Science and Technology Avant‑Garde Research (X‑Star)
kn-affil=

affil-num=5
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Atmosphere and  Ocean Research Institute, The University of Tokyo
kn-affil=

affil-num=8
en-affil=Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=1
article-no=
start-page=537
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230111
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Semiconductor-metal transition in Bi2Se3 caused by impurity doping
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Doping a typical topological insulator, Bi2Se3, with Ag impurity causes a semiconductor-metal (S-M) transition at 35 K. To deepen the understanding of this phenomenon, structural and transport properties of Ag-doped Bi2Se3 were studied. Single-crystal X-ray diffraction (SC-XRD) showed no structural transitions but slight shrinkage of the lattice, indicating no structural origin of the transition. To better understand electronic properties of Ag-doped Bi2Se3, extended analyses of Hall effect and electric-field effect were carried out. Hall effect measurements revealed that the reduction of resistance was accompanied by increases in not only carrier density but carrier mobility. The field-effect mobility is different for positive and negative gate voltages, indicating that the E-F is located at around the bottom of the bulk conduction band (BCB) and that the carrier mobility in the bulk is larger than that at the bottom surface at all temperatures. The pinning of the E-F at the BCB is found to be a key issue to induce the S-M transition, because the transition can be caused by depinning of the E-F or the crossover between the bulk and the top surface transport.
en-copyright=
kn-copyright=

en-aut-name=UchiyamaTakaki
en-aut-sei=Uchiyama
en-aut-mei=Takaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=GotoHidenori
en-aut-sei=Goto
en-aut-mei=Hidenori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=UesugiEri
en-aut-sei=Uesugi
en-aut-mei=Eri
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TakaiAkihisa
en-aut-sei=Takai
en-aut-mei=Akihisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ZhiLei
en-aut-sei=Zhi
en-aut-mei=Lei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MiuraAkari
en-aut-sei=Miura
en-aut-mei=Akari
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=HamaoShino
en-aut-sei=Hamao
en-aut-mei=Shino
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=EguchiRitsuko
en-aut-sei=Eguchi
en-aut-mei=Ritsuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OtaHiromi
en-aut-sei=Ota
en-aut-mei=Hiromi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=SugimotoKunihisa
en-aut-sei=Sugimoto
en-aut-mei=Kunihisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=FujiwaraAkihiko
en-aut-sei=Fujiwara
en-aut-mei=Akihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=MatsuiFumihiko
en-aut-sei=Matsui
en-aut-mei=Fumihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=KimuraKoji
en-aut-sei=Kimura
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=HayashiKouichi
en-aut-sei=Hayashi
en-aut-mei=Kouichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=UenoTeppei
en-aut-sei=Ueno
en-aut-mei=Teppei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=KobayashiKaya
en-aut-sei=Kobayashi
en-aut-mei=Kaya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=AkimitsuJun
en-aut-sei=Akimitsu
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=KubozonoYoshihiro
en-aut-sei=Kubozono
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

affil-num=1
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=2
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=3
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=4
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=5
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=6
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=7
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=8
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=9
en-affil=Advanced Science Research Center, Okayama University
kn-affil=

affil-num=10
en-affil=Faculty of Science and Engineering, Kindai University
kn-affil=

affil-num=11
en-affil=Department of Nanotechnology for Sustainable Energy, Kwansei Gakuin University
kn-affil=

affil-num=12
en-affil=Institute for Molecular Science, UVSOR Synchrotron Facility
kn-affil=

affil-num=13
en-affil=Department of Physical Science and Engineering, Nagoya Institute of Technology
kn-affil=

affil-num=14
en-affil=Department of Physical Science and Engineering, Nagoya Institute of Technology
kn-affil=

affil-num=15
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=16
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=17
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=18
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=25
cd-vols=
no-issue=
article-no=
start-page=100405
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202301
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Patient-specific respiratory motion management using lung tumors vs fiducial markers for real-time tumor-tracking stereotactic body radiotherapy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background and purpose: In real-time lung tumor-tracking stereotactic body radiotherapy (SBRT), tracking accuracy is related to radiotherapy efficacy. This study aimed to evaluate the respiratory movement relationship between a lung tumor and a fiducial marker position in each direction using four-dimensional (4D) computed tomography (CT) images.<br>
Materials and methods: A series of 31 patients with a fiducial marker for lung SBRT was retrospectively analyzed using 4DCT. In the upper (UG) and middle and lower lobe groups (MLG), the cross-correlation coefficients of respiratory movement between the lung tumor and fiducial marker position in four directions (anterior–posterior, left–right, superior–inferior [SI], and three-dimensional [3D]) were calculated for each gating window (≤1, ≤2, and ≤ 3 mm). Subsequently, the proportions of phase numbers in unplanned irradiation (with lung tumors outside the gating window and fiducial markers inside the gating window) were calculated for each gating window.<br>
Results: In the SI and 3D directions, the cross-correlation coefficients were significantly different between UG (mean r = 0.59, 0.63, respectively) and MLG (mean r = 0.95, 0.97, respectively). In both the groups, the proportions of phase numbers in unplanned irradiation were 11 %, 28 %, and 63 % for the ≤ 1-, ≤2-, and ≤ 3-mm gating windows, respectively.<br>
Conclusions: Compared with MLG, fiducial markers for UG have low cross-correlation coefficients between the lung tumor and the fiducial marker position. Using 4DCT to assess the risk of unplanned irradiation in a gating window setting and selecting a high cross-correlation coefficient fiducial marker in advance are important for accurate treatment using lung SBRT.
en-copyright=
kn-copyright=

en-aut-name=TanabeYoshinori
en-aut-sei=Tanabe
en-aut-mei=Yoshinori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KiritaniMichiru
en-aut-sei=Kiritani
en-aut-mei=Michiru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=DeguchiTomomi
en-aut-sei=Deguchi
en-aut-mei=Tomomi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HiraNanami
en-aut-sei=Hira
en-aut-mei=Nanami
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TomimotoSyouta
en-aut-sei=Tomimoto
en-aut-mei=Syouta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Faculty of Medicine, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Facilty of Health Sciences, Okayama University Medical School
kn-affil=

affil-num=3
en-affil=Facilty of Health Sciences, Okayama University Medical School
kn-affil=

affil-num=4
en-affil=Facilty of Health Sciences, Okayama University Medical School
kn-affil=

affil-num=5
en-affil=Facilty of Health Sciences, Okayama University Medical School
kn-affil=
en-keyword=Patient-specific respiratory motion management
kn-keyword=Patient-specific respiratory motion management
en-keyword=Stereotactic body radiotherapy
kn-keyword=Stereotactic body radiotherapy
en-keyword=Four-dimensional computed tomography
kn-keyword=Four-dimensional computed tomography
en-keyword=Fiducial marker
kn-keyword=Fiducial marker
en-keyword=Lung cancer
kn-keyword=Lung cancer
en-keyword=Gating window
kn-keyword=Gating window
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=82
end-page=87
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20221012
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Statistical evaluation of the effectiveness of dual amplitude-gated stereotactic body radiotherapy using fiducial markers and lung volume
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background and purpose: The low tracking accuracy of lung stereotactic body radiotherapy (SBRT) risks reduced treatment efficacy. We used four-dimensional computed tomography (4DCT) images to determine the correlation between changes in fiducial marker positions and lung volume for lung tumors, and we evaluated the effectiveness of the combined use of these images in lung SBRT.<br>
Materials and methods: Data of 30 patients who underwent fiducial marker placement were retrospectively analyzed. We calculated the motion amplitudes of the center of gravity coordinates of the lung tumor and fiducial markers in each phase and the ipsilateral, contralateral, and bilateral lung volumes using 4DCT. Moreover, we calculated the cross-correlation coefficient between the fiducial marker position and the lung volume changes waveform for the motion amplitude waveform of the lung tumor over three gating windows (all phases, ≤2 mm3, and ≤3 mm3).<br>
Results: Compared with the lung volume, approximately 30 % of the fiducial markers demonstrated a low correlation with the lung tumor. In the ≤2 mm3 and ≤3 mm3 gating windows, the cross-correlation coefficients between the lung tumor and the optimal marker (r > 0.9: 83 % and 86 %) were significantly different for all fiducial markers (r > 0.9: 39 %, 53 %) and the ipsilateral (r > 0.9: 35 % and 40 %), contralateral (r > 0.9: 44 % and 41 %), and bilateral (r > 0.9: 39 % and 45 %) lung volumes.<br>
Conclusions: Some of the fiducial markers showed a low correlation with the lung tumor. This study indicated that the combined use of lung volume monitoring can improve tracking accuracy.
en-copyright=
kn-copyright=

en-aut-name=TanabeYoshinori
en-aut-sei=Tanabe
en-aut-mei=Yoshinori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TanakaHidekazu
en-aut-sei=Tanaka
en-aut-mei=Hidekazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Department of Radiological Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Radiation Oncology, Yamaguchi University Graduate School of Medicine
kn-affil=
en-keyword=Fiducial marker
kn-keyword=Fiducial marker
en-keyword=Respiratory gating method
kn-keyword=Respiratory gating method
en-keyword=Stereotactic body radiotherapy
kn-keyword=Stereotactic body radiotherapy
en-keyword=Tumor tracking
kn-keyword=Tumor tracking
en-keyword=Lung cancer
kn-keyword=Lung cancer
en-keyword=4DCT
kn-keyword=4DCT
END

start-ver=1.4
cd-journal=joma
no-vol=126
cd-vols=
no-issue=38
article-no=
start-page=7212
end-page=7228
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220915
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Roles of the Flexible Primary Coordination Sphere of the Mn4CaOx Cluster: What Are the Immediate Decay Products of the S-3 State?
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The primary coordination sphere of the multinuclear cofactor (Mn4CaOx) in the oxygen-evolving complex (OEC) of photosystem II is absolutely conserved to maintain its structure and function. Recent time-resolved serial femtosecond crystallography identified large reorganization of the primary coordination sphere in the S-2 to S-3 transition, which elicits a cascade of events involving Mn oxidation and water molecule binding to a putative catalytic Mn site. We examined how the crystallographic fields, created by transient conformational states of the OEC at various time points, affect the thermodynamics of various isomers of the Mn cluster using DFT calculations, with an aim of comprehending the functional roles of the flexible primary coordination sphere in the S-2 to S-3 transition and in the recovery of the S-2 state. The results show that the relative movements of surrounding residues change the size and shape of the cavity of the cluster and thereby affect the thermodynamics of various catalytic intermediates as well as the ability to capture a new water molecule at a coordinatively unsaturated site. The implication of these findings is that the protein dynamics may serve to gate the catalytic reaction efficiently by controlling the sequence of Mn oxidation/reduction and water binding/release. This interpretation is consistent with EPR experiments; g similar to 5 and g similar to 3 signals obtained after near-infrared (NIR) excitation of the S-3 state at 4 K and a g similar to 5 only signal produced after prolonged incubation of the S-3 state at 77 K can be best explained as originating from water-bound S-2 clusters (S-total = 7/2) under a S-3 ligand field, i.e., the immediate one-electron reduction products of the oxyl-oxo (S-total = 6) and hydroxo-oxo (S-total = 3) species in the S-3 state.
en-copyright=
kn-copyright=

en-aut-name=IsobeHiroshi
en-aut-sei=Isobe
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ShojiMitsuo
en-aut-sei=Shoji
en-aut-mei=Mitsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SuzukiTakayoshi
en-aut-sei=Suzuki
en-aut-mei=Takayoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ShenJian-Ren
en-aut-sei=Shen
en-aut-mei=Jian-Ren
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YamaguchiKizashi
en-aut-sei=Yamaguchi
en-aut-mei=Kizashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=2
en-affil=Center for Computational Science, University of Tsukuba,
kn-affil=

affil-num=3
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=4
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=5
en-affil=Institute for NanoScience Design, Osaka University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=5
article-no=
start-page=489
end-page=502
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202210
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Current Insights into Mesenchymal Signatures in Glioblastoma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Glioblastoma (GBM) is a fatal primary malignant brain tumor in adults. Despite decades of research, the prognosis for GBM patients is still disappointing. One major reason for the intense therapeutic resistance of GBM is inter- and intra-tumor heterogeneity. GBM-intrinsic transcriptional profiling has suggested the presence of at least three subtypes of GBM: the proneural, classic, and mesenchymal subtypes. The mesenchymal subtype is the most aggressive, and patients with the mesenchymal subtype of primary and recurrent tumors tend to have a worse prognosis compared with patients with the other subtypes. Furthermore, GBM can shift from other subtypes to the mesenchymal subtype over the course of disease progression or recurrence. This phenotypic transition is driven by diverse tumor-intrinsic molecular mechanisms or microenvironmental factors. Thus, better understanding of the plastic nature of mesenchymal transition in GBM is pivotal to developing new therapeutic strategies. In this review, we provide a comprehensive overview of the current understanding of the elements involved in the mesenchymal transition of GBM and discuss future perspectives.
en-copyright=
kn-copyright=

en-aut-name=MatsumotoYuji
en-aut-sei=Matsumoto
en-aut-mei=Yuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IchikawaTomotsugu
en-aut-sei=Ichikawa
en-aut-mei=Tomotsugu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KurozumiKazuhiko
en-aut-sei=Kurozumi
en-aut-mei=Kazuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=DateIsao
en-aut-sei=Date
en-aut-mei=Isao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Neurological Surgery, Kagawa Prefectural Central Hospital
kn-affil=

affil-num=3
en-affil=Department of Neurosurgery, Hamamatsu University Hospital
kn-affil=

affil-num=4
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
en-keyword=glioma
kn-keyword=glioma
en-keyword=glioblastoma
kn-keyword=glioblastoma
en-keyword=mesenchymal subtype
kn-keyword=mesenchymal subtype
en-keyword=mesenchymal transition
kn-keyword=mesenchymal transition
en-keyword=heterogeneity
kn-keyword=heterogeneity
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=4
article-no=
start-page=415
end-page=421
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202208
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=5-Nitro-2-(3-phenylpropylamino) Benzoic Acid Inhibits the Proliferation and Migration of Lens Epithelial Cells by Blocking CaMKII Signaling
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Posterior capsule opacification (PCO) is a post-surgery complication of cataract surgery, and lens epithelial cells (LECs) are involved in its development. A suppressive effect on LECs is exerted by the non specific chloride channel inhibitor 5-nitro-2-(3-phenylpropylamino) benzoic acid (NPPB) exerts. Herein, the growth and migration inhibitory effects of NPPB on LECs were assessed, and the mechanism underlying the effects were investigated by focusing on Ca2+/CaMKII signaling. LECs were treated with different concentrations of NPPB, and the changes in cell viability, cell-cycle distribution, anchorage-dependent growth, migration, Ca2+ level, and CaMKII expression were evaluated. NPPB inhibited LECs’ proliferation and induced G1 cell-cycle arrest in the cells. Regarding LECs’ mobility, NPPB suppressed the cells’ anchorage-dependent growth ability and inhibited their migration. Changes in cell phenotypes were associated with an increased intracellular Ca2+ level and down-regulation of CaMKII. Together these results confirmed the inhibitory effect of NPPB on the proliferation and migration of LECs, and the effect was shown to be associated with the induced level of Ca2+ and the inhibition of CaMKII signaling transduction.
en-copyright=
kn-copyright=

en-aut-name=KangHaijun
en-aut-sei=Kang
en-aut-mei=Haijun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HuangDongmei
en-aut-sei=Huang
en-aut-mei=Dongmei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KangGangjin
en-aut-sei=Kang
en-aut-mei=Gangjin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YangXu
en-aut-sei=Yang
en-aut-mei=Xu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=LiHeng
en-aut-sei=Li
en-aut-mei=Heng
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=LiuSiyuan
en-aut-sei=Liu
en-aut-mei=Siyuan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=GouWenjun
en-aut-sei=Gou
en-aut-mei=Wenjun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=LiuLinglin
en-aut-sei=Liu
en-aut-mei=Linglin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=QiuYuyan
en-aut-sei=Qiu
en-aut-mei=Yuyan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Ophthalmology, Suining Central Hospital
kn-affil=

affil-num=2
en-affil=Department of Cardiovascular, Suining Central Hospital
kn-affil=

affil-num=3
en-affil=Department of Ophthalmology, The Affiliated Hospital of Southwest Medical University
kn-affil=

affil-num=4
en-affil=Department of Ophthalmology, Suining Central Hospital
kn-affil=

affil-num=5
en-affil=Department of Ophthalmology, Suining Central Hospital
kn-affil=

affil-num=6
en-affil=Department of Ophthalmology, Suining Central Hospital
kn-affil=

affil-num=7
en-affil=Department of Ophthalmology, Suining Central Hospital
kn-affil=

affil-num=8
en-affil=Department of Ophthalmology, Suining Central Hospital
kn-affil=

affil-num=9
en-affil=Department of Ophthalmology, Suining Central Hospital
kn-affil=
en-keyword=5-nitro-2-(3-phenylpropylamino) benzoic acid
kn-keyword=5-nitro-2-(3-phenylpropylamino) benzoic acid
en-keyword=CaMKII
kn-keyword=CaMKII
en-keyword=lens epithelial cell
kn-keyword=lens epithelial cell
en-keyword=migration
kn-keyword=migration
en-keyword=proliferation
kn-keyword=proliferation
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=3
article-no=
start-page=255
end-page=263
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202206
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Intrathecal Administration of the α1 Adrenergic Antagonist Phentolamine Upregulates Spinal GLT-1 and Improves Mirror Image Pain in SNI Model Rats
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Mirror image pain (MIP) is a type of extraterritorial pain that results in contralateral pain or allodynia. Glutamate transporter-1 (GLT-1) is expressed in astrocytes and plays a role in maintaining low glutamate levels in the synaptic cleft. Previous studies have shown that GLT-1 dysfunction induces neuropathic pain. Our previous study revealed bilateral GLT-1 downregulation in the spinal cord of a spared nerve injury (SNI) rat. We hypothesized that spinal GLT-1 is involved in the mechanism of MIP. We also previously demonstrated noradrenergic GLT-1 regulation. Therefore, this study aimed to investigate the effect of an α1 adrenergic antagonist on the development of MIP. Rats were subjected to SNI. Changes in pain behavior and GLT-1 protein levels in the SNI rat spinal cords were then examined by intrathecal administration of the α1 adrenergic antagonist phentolamine, followed by von Frey test and western blotting. SNI resulted in the development of MIP and bilateral downregulation of GLT-1 protein in the rat spinal cord. Intrathecal phentolamine increased contralateral GLT-1 protein levels and partially ameliorated the 50% paw withdrawal threshold in the contralateral hind paw. Spinal GLT-1 upregulation by intrathecal phentolamine ameliorates MIP. GLT-1 plays a role in the development of MIPs.
en-copyright=
kn-copyright=

en-aut-name=NakatsukaKosuke
en-aut-sei=Nakatsuka
en-aut-mei=Kosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MatsuokaYoshikazu
en-aut-sei=Matsuoka
en-aut-mei=Yoshikazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KuritaMasako
en-aut-sei=Kurita
en-aut-mei=Masako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=WangRuilin
en-aut-sei=Wang
en-aut-mei=Ruilin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TsuboiChika
en-aut-sei=Tsuboi
en-aut-mei=Chika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SueNobutaka
en-aut-sei=Sue
en-aut-mei=Nobutaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KakuRyuji
en-aut-sei=Kaku
en-aut-mei=Ryuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MorimatsuHiroshi
en-aut-sei=Morimatsu
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Kinoshita Pain Clinic
kn-affil=

affil-num=4
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=alpha adrenergic receptor
kn-keyword=alpha adrenergic receptor
en-keyword=glutamate transporter-1
kn-keyword=glutamate transporter-1
en-keyword=mirror image pain
kn-keyword=mirror image pain
en-keyword=neuropathic pain
kn-keyword=neuropathic pain
en-keyword=spared nerve injury
kn-keyword=spared nerve injury
END

start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=1
article-no=
start-page=141
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Enhancement of pacing function by HCN4 overexpression in human pluripotent stem cell-derived cardiomyocytes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background The number of patients with bradyarrhythmia and the number of patients with cardiac pacemakers are increasing with the aging population and the increase in the number of patients with heart diseases. Some patients in whom a cardiac pacemaker has been implanted experience problems such as pacemaker infection and inconvenience due to electromagnetic interference. We have reported that overexpression of HCN channels producing a pacemaker current in mouse embryonic stem cell-derived cardiomyocytes showed enhanced pacing function in vitro and in vivo. The aim of this study was to determine whether HCN4 overexpression in human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) can strengthen the pacing function of the cells. Methods Human HCN4 was transduced in the AAVS1 locus of human induced pluripotent stem cells by nucleofection and HCN4-overexpressing iPSC-CMs were generated. Gene expression profiles, frequencies of spontaneous contraction and pacing abilities of HCN4-overexpressing and non-overexpressing iPSC-CMs in vitro were compared. Results HCN4-overexpressing iPSC-CMs showed higher spontaneous contraction rates than those of non-overexpressing iPSC-CMs. They responded to an HCN channel blocker and beta adrenergic stimulation. The pacing rates against parent iPSC line-derived cardiomyocytes were also higher in HCN4-overexpressing iPSC-CMs than in non-overexpressing iPSC-CMs. Conclusions Overexpression of HCN4 showed enhancement of I-f current, spontaneous firing and pacing function in iPSC-CMs. These data suggest this transgenic cell line may be useful as a cardiac pacemaker.
en-copyright=
kn-copyright=

en-aut-name=SaitoYukihiro
en-aut-sei=Saito
en-aut-mei=Yukihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NakamuraKazufumi
en-aut-sei=Nakamura
en-aut-mei=Kazufumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YoshidaMasashi
en-aut-sei=Yoshida
en-aut-mei=Masashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SugiyamaHiroki
en-aut-sei=Sugiyama
en-aut-mei=Hiroki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=AkagiSatoshi
en-aut-sei=Akagi
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MiyoshiToru
en-aut-sei=Miyoshi
en-aut-mei=Toru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MoritaHiroshi
en-aut-sei=Morita
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=ItoHiroshi
en-aut-sei=Ito
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Cardiovascular Medicine, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Cardiovascular Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=3
en-affil=Department of Chronic Kidney Disease and Cardiovascular Disease, Dentistry, and Pharmaceutical Science, Okayama University Graduate School of Medicine
kn-affil=

affil-num=4
en-affil=Department of Internal Medicine, Okayama Saiseikai General Hospital
kn-affil=

affil-num=5
en-affil=Department of Cardiovascular Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=6
en-affil=Department of Cardiovascular Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=7
en-affil=Department of Cardiovascular Therapeutics, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=8
en-affil=Department of Cardiovascular Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=
en-keyword=Hyperpolarization-activated cyclic nucleotide-gated potassium channel 4
kn-keyword=Hyperpolarization-activated cyclic nucleotide-gated potassium channel 4
en-keyword=Human induced pluripotent stem cell-derived cardiomyocytes
kn-keyword=Human induced pluripotent stem cell-derived cardiomyocytes
en-keyword=Pacing
kn-keyword=Pacing
END

start-ver=1.4
cd-journal=joma
no-vol=2021
cd-vols=
no-issue=
article-no=
start-page=4629459
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20211206
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Number of Frames on ECG-Gated F-18-FDG Small Animal PET Has a Significant Impact on LV Systolic and Diastolic Functional Parameters
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Objectives. This study is aimed at investigating the impact of frame numbers in preclinical electrocardiogram- (ECG-) gated F-18-fluorodeoxyglucose (F-18-FDG) positron emission tomography (PET) on systolic and diastolic left ventricular (LV) parameters in rats. Methods. F-18-FDG PET imaging using a dedicated small animal PET system with list mode data acquisition and continuous ECG recording was performed in diabetic and control rats. The list-mode data was sorted and reconstructed with different numbers of frames (4, 8, 12, and 16) per cardiac cycle into tomographic images. Using an automatic ventricular edge detection software, left ventricular (LV) functional parameters, including ejection fraction (EF), end-diastolic (EDV), and end-systolic volume (ESV), were calculated. Diastolic variables (time to peak filling (TPF), first third mean filling rate (1/3 FR), and peak filling rate (PFR)) were also assessed. Results. Significant differences in multiple parameters were observed among the reconstructions with different frames per cardiac cycle. EDV significantly increased by numbers of frames (353.8 & PLUSMN; 57.7 mu l*, 380.8 & PLUSMN; 57.2 mu l*, 398.0 & PLUSMN; 63.1 mu l*, and 444.8 & PLUSMN; 75.3 mu l at 4, 8, 12, and 16 frames, respectively; *P < 0.0001 vs. 16 frames), while systolic (EF) and diastolic (TPF, 1/3 FR and PFR) parameters were not significantly different between 12 and 16 frames. In addition, significant differences between diabetic and control animals in 1/3 FR and PFR in 16 frames per cardiac cycle were observed (P < 0.005), but not for 4, 8, and 12 frames. Conclusions. Using ECG-gated PET in rats, measurements of cardiac function are significantly affected by the frames per cardiac cycle. Therefore, if you are going to compare those functional parameters, a consistent number of frames should be used.
en-copyright=
kn-copyright=

en-aut-name=EisslerChristoph
en-aut-sei=Eissler
en-aut-mei=Christoph
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=WernerRudolf A.
en-aut-sei=Werner
en-aut-mei=Rudolf A.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=Arias-LozaPaula
en-aut-sei=Arias-Loza
en-aut-mei=Paula
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NoseNaoko
en-aut-sei=Nose
en-aut-mei=Naoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ChenXinyu
en-aut-sei=Chen
en-aut-mei=Xinyu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=PomperMartin G.
en-aut-sei=Pomper
en-aut-mei=Martin G.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=RoweSteven P.
en-aut-sei=Rowe
en-aut-mei=Steven P.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=LapaConstantin
en-aut-sei=Lapa
en-aut-mei=Constantin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=BuckAndreas K.
en-aut-sei=Buck
en-aut-mei=Andreas K.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=HiguchiTakahiro
en-aut-sei=Higuchi
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Nuclear Medicine, University Hospital Würzburg
kn-affil=

affil-num=2
en-affil=Department of Nuclear Medicine, University Hospital Würzburg
kn-affil=

affil-num=3
en-affil=Department of Nuclear Medicine, University Hospital Würzburg
kn-affil=

affil-num=4
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Nuclear Medicine, University Hospital Würzburg
kn-affil=

affil-num=6
en-affil=The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine
kn-affil=

affil-num=7
en-affil=The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine
kn-affil=

affil-num=8
en-affil=Department of Nuclear Medicine, University Hospital Augsburg
kn-affil=

affil-num=9
en-affil=Department of Nuclear Medicine, University Hospital Würzburg
kn-affil=

affil-num=10
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=10
cd-vols=
no-issue=
article-no=
start-page=e72264
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20211221
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Proton transfer pathway in anion channelrhodopsin-1
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Anion channelrhodopsin from Guillardia theta (GtACR1) has Asp234 (3.2 angstrom) and Glu68 (5.3 angstrom) near the protonated Schiff base. Here, we investigate mutant GtACR1s (e.g., E68Q/D234N) expressed in HEK293 cells. The influence of the acidic residues on the absorption wavelengths was also analyzed using a quantum mechanical/molecular mechanical approach. The calculated protonation pattern indicates that Asp234 is deprotonated and Glu68 is protonated in the original crystal structures. The D234E mutation and the E68Q/D234N mutation shorten and lengthen the measured and calculated absorption wavelengths, respectively, which suggests that Asp234 is deprotonated in the wild-type GtACR1. Molecular dynamics simulations show that upon mutation of deprotonated Asp234 to asparagine, deprotonated Glu68 reorients toward the Schiff base and the calculated absorption wavelength remains unchanged. The formation of the proton transfer pathway via Asp234 toward Glu68 and the disconnection of the anion conducting channel are likely a basis of the gating mechanism.
en-copyright=
kn-copyright=

en-aut-name=TsujimuraMasaki
en-aut-sei=Tsujimura
en-aut-mei=Masaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KojimaKeiichi
en-aut-sei=Kojima
en-aut-mei=Keiichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KawanishiShiho
en-aut-sei=Kawanishi
en-aut-mei=Shiho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SudoYuki
en-aut-sei=Sudo
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=IshikitaHiroshi
en-aut-sei=Ishikita
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Applied Chemistry, The University of Tokyo
kn-affil=

affil-num=2
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Applied Chemistry, The University of Tokyo
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=23
cd-vols=
no-issue=9
article-no=
start-page=1168
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210905
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Consideration for Affects of an XOR in a Random Number Generator Using Ring Oscillators
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A cloud service to offer entropy has been paid much attention to. As one of the entropy sources, a physical random number generator is used as a true random number generator, relying on its irreproducibility. This paper focuses on a physical random number generator using a field-programmable gate array as an entropy source by employing ring oscillator circuits as a representative true random number generator. This paper investigates the effects of an XOR gate in the oscillation circuit by observing the output signal period. It aims to reveal the relationship between inputs and the output through the XOR gate in the target generator. The authors conduct two experiments to consider the relevance. It is confirmed that combining two ring oscillators with an XOR gate increases the complexity of the output cycle. In addition, verification using state transitions showed that the probability of the state transitions was evenly distributed by increasing the number of ring oscillator circuits.
en-copyright=
kn-copyright=

en-aut-name=SatoRyoichi
en-aut-sei=Sato
en-aut-mei=Ryoichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KoderaYuta
en-aut-sei=Kodera
en-aut-mei=Yuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=AliMd. Arshad
en-aut-sei=Ali
en-aut-mei=Md. Arshad
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KusakaTakuya
en-aut-sei=Kusaka
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NogamiYasuyuki
en-aut-sei=Nogami
en-aut-mei=Yasuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=Morelos-ZaragozaRobert H.
en-aut-sei=Morelos-Zaragoza
en-aut-mei=Robert H.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Computer Science and Engineering, Hajee Mohammad Danesh Science and Technology University (HSTU)
kn-affil=

affil-num=4
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Electrical Engineering, San José State University
kn-affil=
en-keyword=entropy
kn-keyword=entropy
en-keyword=field programmable gate array
kn-keyword=field programmable gate array
en-keyword=true random number generator
kn-keyword=true random number generator
en-keyword=period
kn-keyword=period
en-keyword=ring oscillator
kn-keyword=ring oscillator
en-keyword=stomatic process
kn-keyword=stomatic process
en-keyword=state transition
kn-keyword=state transition
en-keyword=XOR gate
kn-keyword=XOR gate
END

start-ver=1.4
cd-journal=joma
no-vol=139
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=202110
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Reduction of macrophages by carrageenan decreases oocyst output and modifies local immune reaction in chick cecum with Eimeria tenella
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This study aimed to evaluate the disease severity and local immune responses in macrophage-depleted chicks with Eimeria tenella. Macrophages were reduced by intraperitoneal injection of a carrageenan solution at 12, 13, and 16 days old, whereas the control group received intraperitoneal phosphate-buffered saline. Both chick groups were orally inoculated with E. tenella sporulated oocysts at 14 days old. Feces were collected daily, which were then quantified for oocysts. The chicks were sacrificed on day 5, and the ceca were collected for histopathological observation. The gene expression levels were measured using real-time quantitative reverse transcription-polymerase chain reaction. Macrophage-depleted chicks have been observed to shed a significantly reduced number of fecal oocysts compared to the infected control group. The parasite burden score in cecum specimens of macrophage-depleted chicks was significantly lower than those of infected control on day 5 after infection. Furthermore, macrophage reduction yielded significantly lower cecum histopathological scores and CD4 expression than those of the infected control group. The expression of interleukin (IL)-18, IL-22, interferon-γ, and inducible nitric oxide synthase was also noted to be significantly upregulated in both infected control and macrophage-depleted chicks compared to uninfected chicks. IL-4, IL-13, IL-17, and perforin expressions were also higher with macrophage depletion than in both control groups. These results suggest that macrophages serve as an invasive gate or a transporting vehicle to the site of first merogony. Furthermore, mononuclear phagocytes may play an important role in local immune responses, thus contributing to parasite development during early E. tenella infection.
en-copyright=
kn-copyright=

en-aut-name=HoDung Thi
en-aut-sei=Ho
en-aut-mei=Dung Thi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=PhamHung Hoang Son
en-aut-sei=Pham
en-aut-mei=Hung Hoang Son
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=AotaWataru
en-aut-sei=Aota
en-aut-mei=Wataru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MatsubayashiMakoto
en-aut-sei=Matsubayashi
en-aut-mei=Makoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TsujiNaotoshi
en-aut-sei=Tsuji
en-aut-mei=Naotoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=HatabuToshimitsu
en-aut-sei=Hatabu
en-aut-mei=Toshimitsu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Laboratory of Animal Physiology, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Laboratory of Animal Physiology, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Laboratory of Animal Physiology, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
kn-affil=

affil-num=5
en-affil=Department of Parasitology and Tropical Medicine, Kitasato University School of Medicine
kn-affil=

affil-num=6
en-affil=Laboratory of Animal Physiology, Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=Eimeria tenella
kn-keyword=Eimeria tenella
en-keyword=Local immune response
kn-keyword=Local immune response
en-keyword=Macrophage
kn-keyword=Macrophage
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=4
article-no=
start-page=447
end-page=453
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=202108
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Clinical Parameters Reflecting Globe/orbit Volume Imbalances in Japanese Acquired Esotropia Patients with High Myopia but without Abduction Limitations
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In high myopia, eye dislocation due to increased globe volume or tight orbital volume causes acquired esotro-pia. GOR (globe/orbit volume ratio), an indicator of the degree of progression of this pathology, was investi-gated the relationships among easily obtained clinical parameters. In this retrospective study, 20 eyes from 10 acquired esotropia patients with high myopia but without abduction limitations were examined. The mean age of the patients was 63.7 ± 8.2 years (mean ± standard deviation). Volumes were measured on the three-dimen-sional fast imaging employing steady-state acquisition magnetic resonance imaging images using the vol-ume-measurement function. Correlations between GOR and the displacement angle of the globe (DA), axial length (AL), and equatorial diameter (ED) were investigated. Mean DA, AL, ED, and GOR values were 107.5 ± 8.5°, 28.86 ± 1.92 mm, 25.00 ± 1.16 mm, and 0.36 ± 0.05, respectively. Only AL was correlated with GOR (p < 0.0001, R2 = 0.6649); DA (p = 0.30, R2 = 0.0633) and ED (p = 0.91, R2 = 0.0008) were not. AL was the only clinically available parameter to indicate globe/orbit volume imbalances in acquired esotropia with high myopia but without abduction limitation. AL may be important for the clinical assessment of the progression of this pathology.
en-copyright=
kn-copyright=

en-aut-name=KonoReika
en-aut-sei=Kono
en-aut-mei=Reika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HamasakiIchiro
en-aut-sei=Hamasaki
en-aut-mei=Ichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KishimotoFumiko
en-aut-sei=Kishimoto
en-aut-mei=Fumiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OhtuskiHiroshi
en-aut-sei=Ohtuski
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ShibataKiyo
en-aut-sei=Shibata
en-aut-mei=Kiyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MorizaneYuki
en-aut-sei=Morizane
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ShiragaFumio
en-aut-sei=Shiraga
en-aut-mei=Fumio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Ophthalmology, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Ophthalmology, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Division of Ophthalmology, Ibara City Hospital
kn-affil=

affil-num=4
en-affil=Division of Ophthalmology, Okayama Saiseikai General Hospital
kn-affil=

affil-num=5
en-affil=Department of Ophthalmology, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
en-keyword=acquired esotropia
kn-keyword=acquired esotropia
en-keyword=high myopia (high myopes)
kn-keyword=high myopia (high myopes)
en-keyword=globe volume
kn-keyword=globe volume
en-keyword=magnetic resonance imaging
kn-keyword=magnetic resonance imaging
en-keyword=limitation of abduction
kn-keyword=limitation of abduction
END

start-ver=1.4
cd-journal=joma
no-vol=16
cd-vols=
no-issue=3
article-no=
start-page=e0245502
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210304
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Usefulness of right ventriculography compared with computed tomography for ruling out the possibility of lead perforation before lead extraction
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Purpose High-risk patients can be identified by preprocedural computed tomography (CT) before lead extraction. However, CT evaluation may be difficult especially for lead tip identification due to artifacts in the leads. Selective right ventriculography (RVG) may enable preprocedural evaluation of lead perforation. We investigated the efficacy of RVG for identifying right ventricular (RV) lead perforation compared with CT in patients who underwent lead extraction. Methods Ninety-five consecutive patients who were examined by thin-section non-ECG-gated multi-detector CT and RVG before lead extraction were investigated retrospectively. Newly recognized pericardial effusion after lead extraction was used as a reference standard for lead perforation. We analyzed the prevalence of RV lead perforation diagnosed by each method. The difference in the detection rates of lead perforation by RVG and CT was evaluated. Results Of the 115 RV leads in the 95 patients, lead perforation was diagnosed for 35 leads using CT, but the leads for 29 (83%) of those 35 leads diagnosed as lead perforation by CT were shown to be within the right ventricle by RVG. Three patients with 5 leads could not be evaluated by CT due to motion artifacts. The diagnostic accuracies of RVG and CT were significantly different (p < 0.001). There was no complication of pericardial effusion caused by RV lead extraction. Conclusion RVG for identification of RV lead perforation leads to fewer false-positives compared to non-ECG-gated CT. However, even in cases in which lead perforation is diagnosed, most leads may be safely extracted by transvenous lead extraction.
en-copyright=
kn-copyright=

en-aut-name=AsadaSaori
en-aut-sei=Asada
en-aut-mei=Saori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NishiiNobuhiro
en-aut-sei=Nishii
en-aut-mei=Nobuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ShinyaTakayoshi
en-aut-sei=Shinya
en-aut-mei=Takayoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MiyoshiAkihito
en-aut-sei=Miyoshi
en-aut-mei=Akihito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MorimotoYoshimasa
en-aut-sei=Morimoto
en-aut-mei=Yoshimasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MiyamotoMasakazu
en-aut-sei=Miyamoto
en-aut-mei=Masakazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NakagawaKoji
en-aut-sei=Nakagawa
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=NakamuraKazufumi
en-aut-sei=Nakamura
en-aut-mei=Kazufumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MoritaHiroshi
en-aut-sei=Morita
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=ItoHiroshi
en-aut-sei=Ito
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Cardiovascular Therapeutics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Pediatric Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Cardiovascular Therapeutics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=158
cd-vols=
no-issue=
article-no=
start-page=233
end-page=245
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20201215
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Phosphatidylinositol‐3 kinase mediates the sweet suppressive effect of leptin in mouse taste cells
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Leptin is known to selectively suppress neural and taste cell responses to sweet compounds. The sweet suppressive effect of leptin is mediated by the leptin receptor Ob‐Rb, and the ATP‐gated K+ (KATP) channel expressed in some sweet‐sensitive, taste receptor family 1 member 3 (T1R3)‐positive taste cells. However, the intracellular transduction pathway connecting Ob‐Rb to KATP channel remains unknown. Here we report that phosphoinositide 3‐kinase (PI3K) mediates leptin's suppression of sweet responses in T1R3‐positive taste cells. In in situ taste cell recording, systemically administrated leptin suppressed taste cell responses to sucrose in T1R3‐positive taste cells. Such leptin's suppression of sucrose responses was impaired by co‐administration of PI3K inhibitors (wortmannin or LY294002). In contrast, co‐administration of signal transducer and activator of transcription 3 inhibitor (Stattic) or Src homology region 2 domain‐containing phosphatase‐2 inhibitor (SHP099) had no effect on leptin's suppression of sucrose responses, although signal transducer and activator of transcription 3 and Src homology region 2 domain‐containing phosphatase‐2 were expressed in T1R3‐positive taste cells. In peeled tongue epithelium, phosphatidylinositol (3,4,5)‐trisphosphate production and phosphorylation of AKT by leptin were immunohistochemically detected in some T1R3‐positive taste cells but not in glutamate decarboxylase 67‐positive taste cells. Leptin‐induced phosphatidylinositol (3,4,5)‐trisphosphate production was suppressed by LY294002. Thus, leptin suppresses sweet responses of T1R3‐positive taste cells by activation of Ob‐Rb–PI3K–KATP channel pathway. 
en-copyright=
kn-copyright=

en-aut-name=YoshidaRyusuke
en-aut-sei=Yoshida
en-aut-mei=Ryusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MargolskeeRobert F.
en-aut-sei=Margolskee
en-aut-mei=Robert F.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NinomiyaYuzo
en-aut-sei=Ninomiya
en-aut-mei=Yuzo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Oral Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Monell Chemical Senses Center
kn-affil=

affil-num=3
en-affil=Monell Chemical Senses Center
kn-affil=
en-keyword=energy homeostasis
kn-keyword=energy homeostasis
en-keyword=leptin signaling
kn-keyword=leptin signaling
en-keyword=metabolic sensor
kn-keyword=metabolic sensor
en-keyword=obesity
kn-keyword=obesity
en-keyword=sweet receptor cell
kn-keyword=sweet receptor cell
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=6
article-no=
start-page=495
end-page=503
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202012
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Antenatal Care Visits and Adverse Pregnancy Outcomes at a Hospital in Rural Western Province, Rwanda
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In many economically developing countries, and especially in the rural regions of sub-Saharan African coun-tries, there have been only limited investigations into the association between antenatal care (ANC) and adverse pregnancy outcomes. We obtained information on ANC and pregnancy outcomes between 2011 and 2016 from hospital files of pregnant women (n = 4,960) served at a rural hospital in Rwanda, and we examined the associa-tions between their ANC visits and the adverse pregnancy and neonatal outcomes by using univariate and mul-tivariate logistic regression models to estimate the odds ratios (ORs) and 95% confidence intervals (CIs). Most of the pregnant women had ≥ 4 ANC visits, but 39% (n = 1,911) did not have ≥ 3 visits before delivery. The prev-alence of low birth weight (LBW) and that of preterm birth (PTB) were 12% and 9.9%, respectively. Compared to the women who attended only one ANC visit, those who attended ≥ 4 ANC visits had lower risks of LBW (OR 0.20; 95%CI: 0.11-0.36) and PTB (OR 0.28; 95%CI: 0.11-0.76). Frequent ANC visits were also associ-ated with better postnatal outcomes of the newborns. Encouraging women to attend ANC visits before delivery can markedly reduce PTB-related and LBW-related complications, especially in resource-limited settings.
en-copyright=
kn-copyright=

en-aut-name=CalliopeSimba Akintije
en-aut-sei=Calliope
en-aut-mei=Simba Akintije
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YorifujiTakashi
en-aut-sei=Yorifuji
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WadaTakayuki
en-aut-sei=Wada
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MukakarakeMarie Goret
en-aut-sei=Mukakarake
en-aut-mei=Marie Goret
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MutesaLeon
en-aut-sei=Mutesa
en-aut-mei=Leon
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YamamotoTaro
en-aut-sei=Yamamoto
en-aut-mei=Taro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of International Health and Medical Anthropology, Institute of Tropical Medicine, Nagasaki University
kn-affil=

affil-num=2
en-affil=Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Graduate School of Human Life Science, Osaka City University
kn-affil=

affil-num=4
en-affil=Mibilizi District Hospital
kn-affil=

affil-num=5
en-affil=Center for Human Genetics, College of Medicine and Health Sciences, University of Rwanda
kn-affil=

affil-num=6
en-affil=Department of International Health and Medical Anthropology, Institute of Tropical Medicine, Nagasaki University
kn-affil=
en-keyword=antenatal care
kn-keyword=antenatal care
en-keyword=epidemiology
kn-keyword=epidemiology
en-keyword=low birth weight
kn-keyword=low birth weight
en-keyword=preterm birth
kn-keyword=preterm birth
en-keyword=rural
kn-keyword=rural
END

start-ver=1.4
cd-journal=joma
no-vol=10
cd-vols=
no-issue=52
article-no=
start-page=31547
end-page=31552
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200826
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Facile synthesis of picenes incorporating imide moieties at both edges of the molecule and their application to n-channel field-effect transistors
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Picene derivatives incorporating imide moieties along the long-axis direction of the picene core (Cn-PicDIs) were conveniently synthesized through a four-step synthesis. Photochemical cyclization of dinaphthylethenes was used as the key step for constructing the picene skeleton. Field-effect transistor (FET) devices of Cn-PicDIs were fabricated by using ZrO2 as a gate substrate and their FET characteristics were investigated. The FET devices showed normally-off n-channel operation; the averaged electron mobility (μ) was evaluated to be 2(1) × 10−4, 1.0(6) × 10−1 and 1.4(3) × 10−2 cm2 V−1 s−1 for C4-PicDI, C8-PicDI and C12-PicDI, respectively. The maximum μ value as high as 2.0 × 10−1 cm2 V−1 s−1 was observed for C8-PicDI. The electronic spectra of Cn-PicDIs in solution showed the same profiles irrespective of the alkyl chain lengths. In contrast, in thin films, the UV absorption and photoelectron yield spectroscopy (PYS) indicated that the lowest unoccupied molecular orbital (LUMO) level of Cn-PicDIs gradually lowered upon the elongation of the alkyl chains, suggesting that the alkyl chains modify intermolecular interactions between the Cn-PicDI molecules in thin films. The present results provide a new strategy for constructing a high performance n-channel organic semiconductor material by utilizing the electronic features of phenacenes.
en-copyright=
kn-copyright=

en-aut-name=GuoYuxin
en-aut-sei=Guo
en-aut-mei=Yuxin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YoshiokaKaito
en-aut-sei=Yoshioka
en-aut-mei=Kaito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HamaoShino
en-aut-sei=Hamao
en-aut-mei=Shino
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KubozonoYoshihiro
en-aut-sei=Kubozono
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TaniFumito
en-aut-sei=Tani
en-aut-mei=Fumito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=GotoKenta
en-aut-sei=Goto
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=OkamotoHideki
en-aut-sei=Okamoto
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=4
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=5
en-affil=Institute for Materials Chemistry and Engineering, Kyushu University
kn-affil=

affil-num=6
en-affil=Institute for Materials Chemistry and Engineering, Kyushu University
kn-affil=

affil-num=7
en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=15
cd-vols=
no-issue=1
article-no=
start-page=191
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200526
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Short-term outcomes of mirogabalin in patients with peripheral neuropathic pain: a retrospective study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background</br>
Mirogabalin, which is approved for the treatment of peripheral neuropathic pain in Japan, is a ligand for the α2δ subunit of voltage-gated calcium channels. Both pregabalin and mirogabalin act as nonselective ligands at the α2δ-1 and α2δ-2 subunits. Mirogabalin has a unique binding profile and long duration of action. Pregabalin has been reported to produce intolerable adverse effects in some patients. This study investigated outcomes associated with mirogabalin administration in patients with peripheral neuropathic pain who ceased treatment with pregabalin.</br>
Methods</br>
We retrospectively assessed peripheral neuropathic pain using the neuropathic pain screening questionnaire (NeP score) in 187 patients (58 men, 129 women) who were treated with mirogabalin. All patients had switched from pregabalin to mirogabalin due to lack of efficacy or adverse events. Differences in the treatment course (i.e., numeric rating scale (NRS) scores) were compared using one-way analysis of variance with Bonferroni post hoc tests.</br>
Results</br>
The mean age of the patients was 72.3 years (range, 30–94 years), and the mean duration of disease was 37 months (range, 3–252 months). After treatment with mirogabalin for 1 week, NRS scores significantly decreased compared with baseline and continued to decrease over time. After 8 weeks, NRS scores improved by ≥ 30% from baseline in 113 patients (69.3%). Twenty-four patients (12.8%) stopped mirogabalin treatment due to adverse events. Somnolence (26.7%), dizziness (12.3%), edema (5.9%), and weight gain (0.5%) were noted as adverse events of mirogabalin.</br>
Conclusions</br>
The results of this investigation indicate that mirogabalin is safe and effective for reducing peripheral neuropathic pain.
en-copyright=
kn-copyright=

en-aut-name=TetsunagaTomoko
en-aut-sei=Tetsunaga
en-aut-mei=Tomoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TetsunagaTomonori
en-aut-sei=Tetsunaga
en-aut-mei=Tomonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NishidaKeiichiro
en-aut-sei=Nishida
en-aut-mei=Keiichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MisawaHaruo
en-aut-sei=Misawa
en-aut-mei=Haruo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TakigawaTomoyuki
en-aut-sei=Takigawa
en-aut-mei=Tomoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YamaneKentaro
en-aut-sei=Yamane
en-aut-mei=Kentaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TsujiHironori
en-aut-sei=Tsuji
en-aut-mei=Hironori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TakeiYoshitaka
en-aut-sei=Takei
en-aut-mei=Yoshitaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Orthopedic Surgery, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Orthopedic Surgery, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Orthopedic Surgery, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of Orthopedic Surgery, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Orthopedic Surgery, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Orthopedic Surgery, Okayama University Hospital
kn-affil=

affil-num=7
en-affil=Department of Orthopedic Surgery, Okayama University Hospital
kn-affil=

affil-num=8
en-affil=Department of Orthopedic Surgery, Kurashiki Municipal Hospital
kn-affil=

affil-num=9
en-affil=Department of Orthopedic Surgery, Okayama University Hospital
kn-affil=
en-keyword=Peripheral neuropathic pain
kn-keyword=Peripheral neuropathic pain
en-keyword=Mirogabalin
kn-keyword=Mirogabalin
en-keyword=Pregabalin
kn-keyword=Pregabalin
en-keyword=Adverse event
kn-keyword=Adverse event
END

start-ver=1.4
cd-journal=joma
no-vol=8
cd-vols=
no-issue=22
article-no=
start-page=7422
end-page=7435
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200418
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Synthesis of [7]phenacene incorporating tetradecyl chains in the axis positions and its application in field-effect transistors
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Field-effect transistors (FETs) were fabricated using a new type of phenacene molecule, 3,12-ditetradecyl[7]phenacene ((C14H29)2-[7]phenacene), and solid gate dielectrics or an electric double layer (EDL) capacitor with an ionic liquid (1-butyl-3-methylimidazolium hexafluorophosphate (bmim[PF6])). The new molecule, (C14H29)2-[7]phenacene, was efficiently synthesized via the Mallory photoreaction. Its crystal structure and electronic properties were determined, using X-ray diffraction, scanning tunneling microscopy/spectroscopy (STM and STS), absorption spectroscopy, and photoelectron yield spectroscopy, which showed a monoclinic crystal lattice (space group P21 (no. 4)) and an energy gap of ∼3.0 eV. The STM image clearly showed the molecular structure of (C14H29)2-[7]phenacene, as well as the closed molecular stacking, indicative of a strong fastener effect between alkyl chains. The X-ray diffraction pattern of thin films of (C14H29)2-[7]phenacene formed on a SiO2/Si substrate suggested that the molecule stood on the surface with an inclined angle of 30° with respect to the normal axis of the surface. The FET properties were recorded in two-terminal measurement mode, showing p-channel normally-off characteristics. The averaged values of field-effect mobility, μ, were 1.6(3) cm2 V−1 s−1 for a (C14H29)2-[7]phenacene thin-film FET with a SiO2 gate dielectric and 6(4) × 10−1 cm2 V−1 s−1 for a (C14H29)2-[7]phenacene thin-film EDL FET with bmim[PF6]. Thus, higher FET performance was obtained with an FET using a thin film of (C14H29)2-[7]phenacene compared to parent [7]phenacene. This study could pioneer an avenue for the realization of high-performance FETs through the addition of alkyl chains to phenacene molecules.
en-copyright=
kn-copyright=

en-aut-name=OkamotoHideki
en-aut-sei=Okamoto
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HamaoShino
en-aut-sei=Hamao
en-aut-mei=Shino
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KozasaKeiko
en-aut-sei=Kozasa
en-aut-mei=Keiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=WangYanan
en-aut-sei=Wang
en-aut-mei=Yanan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KubozonoYoshihiro
en-aut-sei=Kubozono
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=PanYong-He
en-aut-sei=Pan
en-aut-mei=Yong-He
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YenYu-Hsiang
en-aut-sei=Yen
en-aut-mei=Yu-Hsiang
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=HoffmannGermar
en-aut-sei=Hoffmann
en-aut-mei=Germar
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=TaniFumito
en-aut-sei=Tani
en-aut-mei=Fumito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=GotoKenta
en-aut-sei=Goto
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=5
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Physics & Center for Quantum Technology, National Tsing Hua University
kn-affil=

affil-num=7
en-affil=Department of Physics & Center for Quantum Technology, National Tsing Hua University
kn-affil=

affil-num=8
en-affil=Department of Physics & Center for Quantum Technology, National Tsing Hua University
kn-affil=

affil-num=9
en-affil=Institute for Materials Chemistry and Engineering, Kyushu University
kn-affil=

affil-num=10
en-affil=Institute for Materials Chemistry and Engineering, Kyushu University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=2
article-no=
start-page=123
end-page=128
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202004
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Diagnostic Capacity of Pre-treatment 18F-FDG PET/CT for Predicting the Extranodular Spread of Lymph Node Metastases in Patients with Oral Squamous Cell Carcinoma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= The aim of this study was to evaluate the ability of pretreatment 90-min 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) to predict the extranodular spread of lymph node metastases in oral squamous cell carcinoma. We retrospectively reviewed the cases of 56 patients who underwent pretreatment 18F-FDG PET/CT and surgery with neck dissection. Maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis were measured for the 56 primary sites and maximum standardized uptake value was measured for 115 lymph node levels. Extranodular spread was present at 9 lymph node levels in 7 patients. Significant differences were found in metabolic tumor volume and total lesion glycolysis of the primary site, and in lymph node maximum standardized uptake value, between patients with and without extranodular spread (p<0.05). Combining primary site total lesion glycolysis and lymph node maximum standardized uptake volume at their respective optimal cutoffs, the sensitivity, specificity, and accuracy for predicting extranodular spread were 89%, 92%, and 92%, respectively. Pretreatment 18F-FDG PET/CT is useful for predicting extranodular spread in patients with oral squamous cell carcinoma. The combined use of primary site total lesion glycolysis and lymph node maximum standardized uptake value showed greater predictive value than either predictor singly.
en-copyright=
kn-copyright=

en-aut-name=FukuharaRyuichiro
en-aut-sei=Fukuhara
en-aut-mei=Ryuichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ShinyaTakayoshi
en-aut-sei=Shinya
en-aut-mei=Takayoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=FukumaShogo
en-aut-sei=Fukuma
en-aut-mei=Shogo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OgawaNanako
en-aut-sei=Ogawa
en-aut-mei=Nanako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MasaokaYoshihisa
en-aut-sei=Masaoka
en-aut-mei=Yoshihisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TanakaTakehiro
en-aut-sei=Tanaka
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MarunakaHidenori
en-aut-sei=Marunaka
en-aut-mei=Hidenori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=AriokaTadashi
en-aut-sei=Arioka
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=HirakiTakao
en-aut-sei=Hiraki
en-aut-mei=Takao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KajiMitsumasa
en-aut-sei=Kaji
en-aut-mei=Mitsumasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=KanazawaSusumu
en-aut-sei=Kanazawa
en-aut-mei=Susumu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital
kn-affil=

affil-num=3
en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital
kn-affil=

affil-num=4
en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital
kn-affil=

affil-num=5
en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital
kn-affil=

affil-num=6
en-affil=Department of Pathology, Okayama Diagnostic Imaging Center, Okayama university Hospital
kn-affil=

affil-num=7
en-affil=Department of Otolaryngology-Head & Neck Surgery, Okayama Diagnostic Imaging Center, Okayama university Hospital
kn-affil=

affil-num=8
en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital
kn-affil=

affil-num=9
en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital
kn-affil=

affil-num=10
en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital
kn-affil=

affil-num=11
en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital
kn-affil=
en-keyword=18F-fluorodeoxyglucose positron emission tomography/computed tomography
kn-keyword=18F-fluorodeoxyglucose positron emission tomography/computed tomography
en-keyword=extranodular spread
kn-keyword=extranodular spread
en-keyword=metastasis
kn-keyword=metastasis
en-keyword=oral squamous cell carcinoma
kn-keyword=oral squamous cell carcinoma
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=
article-no=
start-page=4009
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201938
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Synthesis of the extended phenacene molecules, [10]phenacene and [11]phenacene, and their performance in a field-effect transistor 
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= The [10]phenacene and [11]phenacene molecules have been synthesized using a simple repetition of Wittig reactions followed by photocyclization. Sufficient amounts of [10]phenacene and [11]phenacene were obtained, and thin-film FETs using these molecules have been fabricated with SiO2 and ionic liquid gate dielectrics. These FETs operated in p-channel. The averaged measurements of field-effect mobility, <μ>, were 3.1(7) × 10-2 and 1.11(4) × 10-1 cm2 V-1 s-1, respectively, for [10]phenacene and [11]phenacene thin-film FETs with SiO2 gate dielectrics. Furthermore, [10]phenacene and [11]phenacene thin-film electric-double-layer (EDL) FETs with ionic liquid showed low-voltage p-channel FET properties, with <μ> values of 3(1) and 1(1) cm2 V-1 s-1, respectively. This study also discusses the future utility of the extremely extended π-network molecules [10]phenacene and [11]phenacene as the active layer of FET devices, based on the experimental results obtained.
en-copyright=
kn-copyright=

en-aut-name=OkamotoHideki
en-aut-sei=Okamoto
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HamaoShino
en-aut-sei=Hamao
en-aut-mei=Shino
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=EguchiRitsuko
en-aut-sei=Eguchi
en-aut-mei=Ritsuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=GotoHidenori
en-aut-sei=Goto
en-aut-mei=Hidenori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TakabayashiYasuhiro
en-aut-sei=Takabayashi
en-aut-mei=Yasuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YenPaul Yu-Hsiang
en-aut-sei=Yen
en-aut-mei=Paul Yu-Hsiang
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=LiangLuo Uei
en-aut-sei=Liang
en-aut-mei=Luo Uei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=ChouChia-Wei
en-aut-sei=Chou
en-aut-mei=Chia-Wei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=HoffmannGermar
en-aut-sei=Hoffmann
en-aut-mei=Germar
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=GohdaShin
en-aut-sei=Gohda
en-aut-mei=Shin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=SuginoHisako
en-aut-sei=Sugino
en-aut-mei=Hisako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=LiaosYen-Fa
en-aut-sei=Liaos
en-aut-mei=Yen-Fa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=IshiiHirofumi
en-aut-sei=Ishii
en-aut-mei=Hirofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=KubozonoYoshihiro
en-aut-sei=Kubozono
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

affil-num=1
en-affil= Department of Chemistry, Okayama University
kn-affil=

affil-num=2
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=3
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=4
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=5
en-affil= Department of Chemistry, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Physics, National Tsing Hua University
kn-affil=

affil-num=7
en-affil=Department of Physics, National Tsing Hua University
kn-affil=

affil-num=8
en-affil=Department of Physics, National Tsing Hua University
kn-affil=

affil-num=9
en-affil=Department of Physics, National Tsing Hua University
kn-affil=

affil-num=10
en-affil=NARD Co Ltd
kn-affil=

affil-num=11
en-affil=NARD Co Ltd
kn-affil=

affil-num=12
en-affil=National Synchrotron Radiation Center
kn-affil=

affil-num=13
en-affil=National Synchrotron Radiation Center
kn-affil=

affil-num=14
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=
article-no=
start-page=5376
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=2019329
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Fermi level tuning of Ag-doped Bi2Se3 topological insulator
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The temperature dependence of the resistivity (rho) of Ag-doped Bi2Se3 (AgxBi2-xSe3) shows insulating behavior above 35 K, but below 35 K, rho suddenly decreases with decreasing temperature, in contrast to the metallic behavior for non-doped Bi2Se3 at 1.5-300 K. This significant change in transport properties from metallic behavior clearly shows that the Ag doping of Bi2Se3 can effectively tune the Fermi level downward. The Hall effect measurement shows that carrier is still electron in AgxBi2-xSe3 and the electron density changes with temperature to reasonably explain the transport properties. Furthermore, the positive gating of AgxBi2-xSe3 provides metallic behavior that is similar to that of non-doped Bi2Se3, indicating a successful upward tuning of the Fermi level.
en-copyright=
kn-copyright=

en-aut-name=UesugiEri
en-aut-sei=Uesugi
en-aut-mei=Eri
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=UchiyamaTakaki
en-aut-sei=Uchiyama
en-aut-mei=Takaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=GotoHidenori
en-aut-sei=Goto
en-aut-mei=Hidenori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OtaHiromi
en-aut-sei=Ota
en-aut-mei=Hiromi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=UenoTeppei
en-aut-sei=Ueno
en-aut-mei=Teppei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=FujiwaraHirokazu
en-aut-sei=Fujiwara
en-aut-mei=Hirokazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TerashimaKensei
en-aut-sei=Terashima
en-aut-mei=Kensei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=YokoyaTakayoshi
en-aut-sei=Yokoya
en-aut-mei=Takayoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MatsuiFumihiko
en-aut-sei=Matsui
en-aut-mei=Fumihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=AkimitsuJun
en-aut-sei=Akimitsu
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=KobayashiKaya
en-aut-sei=Kobayashi
en-aut-mei=Kaya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=KubozonoYoshihiro
en-aut-sei=Kubozono
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

affil-num=1
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=2
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=3
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=4
en-affil= Advanced Science Research Centre, Okayama University
kn-affil=

affil-num=5
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=6
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=7
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=8
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=9
en-affil=Graduate School of Materials Science, Nara Institute of Science and Technology
kn-affil=

affil-num=10
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=11
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=12
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=383
cd-vols=
no-issue=2
article-no=
start-page=111556
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191015
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Mechanical strain attenuates cytokine-induced ADAMTS9 expression via transient receptor potential vanilloid type 1
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= The synovial fluids of patients with osteoarthritis (OA) contain elevated levels of inflammatory cytokines, which induce the expression of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) and of the matrix metalloproteinase (MMP) in chondrocytes. Mechanical strain has varying effects on organisms depending on the strength, cycle, and duration of the stressor; however, it is unclear under inflammatory stimulation how mechanical strain act on. Here, we show that mechanical strain attenuates inflammatory cytokine-induced expression of matrix-degrading enzymes. Cyclic tensile strain (CTS), as a mechanical stressor, attenuated interleukin (IL)-1β and tumor necrosis factor (TNF)-α-induced mRNA expression of ADAMTS4, ADAMTS9, and MMP-13 in normal chondrocytes (NHAC-kn) and in a chondrocytic cell line (OUMS-27). This effect was abolished by treating cells with mechano-gated channel inhibitors, such as gadolinium, transient receptor potential (TRP) family inhibitor, ruthenium red, and with pharmacological and small interfering RNA-mediated TRPV1 inhibition. Furthermore, nuclear factor κB (NF-κB) translocation from the cytoplasm to the nucleus resulting from cytokine stimulation was also abolished by CTS. These findings suggest that mechanosensors such as the TRPV protein are potential therapeutic targets in treating OA.
en-copyright=
kn-copyright=

en-aut-name=OhtsukiTakashi
en-aut-sei=Ohtsuki
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ShinaokaAkira
en-aut-sei=Shinaoka
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=Kumagishi-ShinaokaKanae
en-aut-sei=Kumagishi-Shinaoka
en-aut-mei=Kanae
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=AsanoKeiichi
en-aut-sei=Asano
en-aut-mei=Keiichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HatipogluOmer Faruk
en-aut-sei=Hatipoglu
en-aut-mei=Omer Faruk
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=InagakiJunko
en-aut-sei=Inagaki
en-aut-mei=Junko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TakahashiKen
en-aut-sei=Takahashi
en-aut-mei=Ken
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OohashiToshitaka
en-aut-sei=Oohashi
en-aut-mei=Toshitaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=NishidaKeiichiro
en-aut-sei=Nishida
en-aut-mei=Keiichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=NaruseKeiji
en-aut-sei=Naruse
en-aut-mei=Keiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=HirohataSatoshi
en-aut-sei=Hirohata
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Human Morphology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Human Morphology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Cell Chemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=49
cd-vols=
no-issue=3
article-no=
start-page=521
end-page=526
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2007
dt-pub=20071121
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Rasmussen encephalitis associated with SCN1A mutation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Mutations in the SCN 1 A gene, encoding the neuronal voltage-gated sodium channel alpha1 subunit, cause SMEI, GEFS+, and related epileptic syndromes. We herein report the R1575C-SCN 1 A mutation identified in a patient with Rasmussen encephalitis. R1575C were constructed in a recombinant human SCN 1 A and then heterologously expressed in HEK293 cells along with the human beta1 and beta2 sodium channel accessory subunits. Whole-cell patch-clamp recording was used to define biophysical properties. The R1575C channels exhibited increased channel availability and an increased persistent sodium current in comparison to the wild-type. These defects of electrophysiological properties can result in neuronal hyperexitability. The seizure susceptibility allele may influence the pathogenesis of Rasmussen encephalitis in this case.
en-copyright=
kn-copyright=

en-aut-name=OhmoriIori
en-aut-sei=Ohmori
en-aut-mei=Iori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OuchidaMamoru
en-aut-sei=Ouchida
en-aut-mei=Mamoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KobayashiKatsuhiro
en-aut-sei=Kobayashi
en-aut-mei=Katsuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=JitsumoriYoshimi
en-aut-sei=Jitsumori
en-aut-mei=Yoshimi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=InoueTakushi
en-aut-sei=Inoue
en-aut-mei=Takushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ShimizuKenji
en-aut-sei=Shimizu
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MatsuiHideki
en-aut-sei=Matsui
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OhtsukaYoko
en-aut-sei=Ohtsuka
en-aut-mei=Yoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MaegakiYoshihiro
en-aut-sei=Maegaki
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Departments of Cellular Physiology, Graduate School of Medicine,Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Departments of Molecular Genetics, Graduate School of Medicine,Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Departments of Child Neurology, Graduate School of Medicine,Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=
kn-affil=

affil-num=5
en-affil=Departments of Child Neurology, Graduate School of Medicine,Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Departments of Molecular Genetics, Graduate School of Medicine,Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Departments of Cellular Physiology, Graduate School of Medicine,Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Departments of Child Neurology, Graduate School of Medicine,Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Division of Child Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University
kn-affil=
en-keyword=Rasmussen encephalitis
kn-keyword=Rasmussen encephalitis
en-keyword=SCN1A
kn-keyword=SCN1A
en-keyword=genetic-environmental interaction
kn-keyword=genetic-environmental interaction
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=1
article-no=
start-page=7863
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190527
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Quantitation of the neural silencing activity of anion channelrhodopsins in Caenorhabditis elegans and their applicability for long-term illumination
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Ion pumps and channels are responsible for a wide variety of biological functions. Ion pumps transport only one ion during each stimulus-dependent reaction cycle, whereas ion channels conduct a large number of ions during each cycle. Ion pumping rhodopsins such as archaerhodopsin-3 (Arch) are often utilized as light-dependent neural silencers in animals, but they require a high-density light illumination of around 1 mW/mm2. Recently, anion channelrhodopsins -1 and -2 (GtACR1 and GtACR2) were discovered as light-gated anion channels from the cryptophyte algae Guillardia theta. GtACRs are therefore expected to silence neural activity much more efficiently than Arch. In this study, we successfully expressed GtACRs in neurons of the nematode Caenorhabditis elegans (C. elegans) and quantitatively evaluated how potently GtACRs can silence neurons in freely moving C. elegans. The results showed that the light intensity required for GtACRs to cause locomotion paralysis was around 1 µW/mm2, which is three orders of magnitude smaller than the light intensity required for Arch. As attractive features, GtACRs are less harmfulness to worms and allow stable neural silencing effects under long-term illumination. Our findings thus demonstrate that GtACRs possess a hypersensitive neural silencing activity in C. elegans and are promising tools for long-term neural silencing.
en-copyright=
kn-copyright=

en-aut-name=YamanashiTaro
en-aut-sei=Yamanashi
en-aut-mei=Taro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=Maki Misayo
en-aut-sei=Maki
en-aut-mei= Misayo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KojimaKeiichi
en-aut-sei=Kojima
en-aut-mei=Keiichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ShibukawaAtsushi
en-aut-sei=Shibukawa
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TsukamotoTakashi
en-aut-sei=Tsukamoto
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ChowdhurySrikanta
en-aut-sei=Chowdhury
en-aut-mei=Srikanta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YamanakaAkihiro
en-aut-sei=Yamanaka
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TakagiShin
en-aut-sei=Takagi
en-aut-mei=Shin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SudoYuki
en-aut-sei=Sudo
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=
kn-affil=

affil-num=7
en-affil=
kn-affil=

affil-num=8
en-affil=
kn-affil=

affil-num=9
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=50
cd-vols=
no-issue=
article-no=
start-page=209
end-page=217
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=201302
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=CACNA1A variants may modify the epileptic phenotype of Dravet syndrome
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Dravet syndrome is an intractable epileptic syndrome beginning in the first year of life. De novo mutations of SCN1A, which encode the Na(v)1.1 neuronal voltage-gated sodium channel, are considered the major cause of Dravet syndrome. In this study, we investigated genetic modifiers of this syndrome. We performed a mutational analysis of all coding exons of CACNA1A in 48 subjects with Dravet syndrome. To assess the effects of CACNA1A variants on the epileptic phenotypes of Dravet syndrome, we compared clinical features in two genotype groups: 1) subjects harboring SCN1A mutations but no CACNA1A variants (n=20) and 2) subjects with SCN1A mutations plus CACNA1A variants (n=20). CACNA1A variants detected in patients were studied using heterologous expression of recombinant human Ca(v)2.1 in HEK 293 cells and whole-cell patch-clamp recording. Nine CACNA1A variants, including six novel ones, were detected in 21 of the 48 subjects (43.8%). Based on the incidence of variants in healthy controls, most of the variants seemed to be common polymorphisms. However, the subjects harboring SCN1A mutations and CACNA1A variants had absence seizures more frequently than the patients with only SCN1A mutations (8/20 vs. 0/20, p=0.002). Moreover, the former group of subjects exhibited earlier onset of seizures and more frequent prolonged seizures before one year of age, compared to the latter group of subjects. The electrophysiological properties of four of the five novel Ca(v)2.1 variants exhibited biophysical changes consistent with gain-of-function. We conclude that CACNA1A variants in some persons with Dravet syndrome may modify the epileptic phenotypes.
en-copyright=
kn-copyright=

en-aut-name=OhmoriIori
en-aut-sei=Ohmori
en-aut-mei=Iori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OuchidaMamoru
en-aut-sei=Ouchida
en-aut-mei=Mamoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KobayashiKatsuhiro
en-aut-sei=Kobayashi
en-aut-mei=Katsuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=JitsumoriYoshimi
en-aut-sei=Jitsumori
en-aut-mei=Yoshimi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MoriAkiko
en-aut-sei=Mori
en-aut-mei=Akiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MichiueHiroyuki
en-aut-sei=Michiue
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NishikiTeiichi
en-aut-sei=Nishiki
en-aut-mei=Teiichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OhtsukaYoko
en-aut-sei=Ohtsuka
en-aut-mei=Yoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MatsuiHideki
en-aut-sei=Matsui
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Molecular Genetics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=
kn-affil=

affil-num=4
en-affil=
kn-affil=

affil-num=5
en-affil=Department of Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=
kn-affil=

affil-num=9
en-affil=Department of Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=3
article-no=
start-page=247
end-page=257
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201906
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Simultaneous Integrated Boost Volumetric Modulated Arc Therapy for Middle or Lower Esophageal Cancer Using Elective Nodal Irradiation: Comparison with 3D Conformal Radiotherapy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= We investigated the feasibility of simultaneous integrated boost (SIB) volumetric modulated arc therapy (VMAT) using elective nodal irradiation (ENI) for middle or lower esophageal cancer and compared it with three-dimensional conformal radiotherapy (3D-CRT). The study included 15 patients. The prescribed doses included a standard dose (50.4 Gy) and a high dose (60 Gy) for the planning target volume (PTV) of the involved lesions. The objective of the whole lung volume receiving ≥ 20 Gy (V20Gy) was < 30%, and the mean lung dose (MLD) was < 20 Gy. The volumes of the lung receiving 5 Gy (V5Gy) and the heart receiving 30-50 Gy (V30-50Gy) were kept as low as reasonably achievable. As a result, SIB-VMAT showed superior dose conformity for the PTV (p<0.001). Although the lung V5Gy was significantly increased (p<0.001), the V20Gy and MLD showed no significant increase. The heart V30-50Gy showed a > 20% reduction in the mean against 3D-CRTs. Our results demonstrate the feasibility of SIB-VMAT for the treatment of middle or lower esophageal cancer with ENI. Although attention should be paid to the low-dose area of the lungs, SIB-VMAT would be a promising treatment option with improved outcomes for esophageal cancer.
en-copyright=
kn-copyright=

en-aut-name=YoshioKotaro
en-aut-sei=Yoshio
en-aut-mei=Kotaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=WakitaAkihisa
en-aut-sei=Wakita
en-aut-mei=Akihisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MitsuhashiToshiharu
en-aut-sei=Mitsuhashi
en-aut-mei=Toshiharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KitayamaTakahiro
en-aut-sei=Kitayama
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HisazumiKento
en-aut-sei=Hisazumi
en-aut-mei=Kento
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=InoueDaisaku
en-aut-sei=Inoue
en-aut-mei=Daisaku
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TajiriNobuhisa
en-aut-sei=Tajiri
en-aut-mei=Nobuhisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=ShiodeTsuyoki
en-aut-sei=Shiode
en-aut-mei=Tsuyoki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=AkakiShiro
en-aut-sei=Akaki
en-aut-mei=Shiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KanazawaSusumu
en-aut-sei=Kanazawa
en-aut-mei=Susumu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Radiology, Kagawa Prefectural Central Hospital
kn-affil=

affil-num=2
en-affil=Division of Medical Physics, Euro MediTech Co. Ltd
kn-affil=

affil-num=3
en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of Radiology, Kagawa Prefectural Central Hospital
kn-affil=

affil-num=5
en-affil=Department of Radiology, Kagawa Prefectural Central Hospital
kn-affil=

affil-num=6
en-affil=Department of Radiology, Kagawa Prefectural Central Hospital
kn-affil=

affil-num=7
en-affil=Department of Radiology, Kagawa Prefectural Central Hospital
kn-affil=

affil-num=8
en-affil=Department of Radiology, Kagawa Prefectural Central Hospital
kn-affil=

affil-num=9
en-affil=Department of Radiology, Kagawa Prefectural Central Hospital
kn-affil=

affil-num=10
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=
en-keyword=esophageal cancer
kn-keyword=esophageal cancer
en-keyword=middle and lower thoracic
kn-keyword=middle and lower thoracic
en-keyword=volumetric modulated arc therapy,
kn-keyword=volumetric modulated arc therapy,
en-keyword=3D-CRT
kn-keyword=3D-CRT
en-keyword=elective nodal irradiation
kn-keyword=elective nodal irradiation
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Dual-Source CTを使用したHigh-Pitch 心電図非同期CTによる小児先天性心疾患患児における冠動脈描出能
kn-title=Image Quality of Coronary Arteries on Non-electrocardiography-gated High-Pitch Dual-Source Computed Tomography in Children with Congenital Heart Disease
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KanieYuichiro
en-aut-sei=Kanie
en-aut-mei=Yuichiro
kn-aut-name=蟹江悠一郎
kn-aut-sei=蟹江
kn-aut-mei=悠一郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=3
article-no=
start-page=267
end-page=273
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=201806
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Image Evaluation of Free-breathing Navigator Echo and Triggered Cardiac-gated Delayed Myocardial Enhancement Magnetic Resonance Imaging in Sedated Infants
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= We validated a navigator-echo-triggered sequence that drives magnetization before cardiac-gated inversion recovery T1 turbo field echo acquisition, in the sedated free-breathing pediatric population. Cardiac magnetic resonance imaging was performed on sedated infants with single ventricle. We calculated the signal-to-noise ratios and contrast-to-noise ratios of 2 groups of images obtained using respiratory triggering with and without navigator echo. All images were then visually assessed by 2 observers. The signal-to-noise ratio and the contrast-to-noise ratio were significantly higher with than without navigator echo (p<0.01; p<0.05). The visual assessment scores were also consistently better with than without navigator echo (p<0.01). Free-breathing navigator echo was found to have the advantage of decreasing the motion artifact caused by respiration. Cardiacgated inversion recovery T1 turbo field echo sequence for free-breathing navigator-echo-triggered respiration allows for the acquisition, in sedated infants, of diagnostic images whose quality exceeds that of the non-navigator-echo-triggered alternative.
en-copyright=
kn-copyright=

en-aut-name=MatsuuraRyutaro
en-aut-sei=Matsuura
en-aut-mei=Ryutaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=GotoSachiko
en-aut-sei=Goto
en-aut-mei=Sachiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SatoShuhei
en-aut-sei=Sato
en-aut-mei=Shuhei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=AkagiNoriaki
en-aut-sei=Akagi
en-aut-mei=Noriaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TaharaSeiji
en-aut-sei=Tahara
en-aut-mei=Seiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Health Informatics, Kawasaki University of Medical Welfare
kn-affil=

affil-num=4
en-affil=Division of Radiology, Department of Medical Technology, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Division of Radiology, Department of Medical Technology, Okayama University Hospital
kn-affil=
en-keyword=magnetic resonance imaging
kn-keyword=magnetic resonance imaging
en-keyword=navigator echo
kn-keyword=navigator echo
en-keyword=inversion recovery T1 turbo field echo
kn-keyword=inversion recovery T1 turbo field echo
en-keyword=cardiac
kn-keyword=cardiac
en-keyword=infant
kn-keyword=infant
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=20180323
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=鎮静乳幼児における自由呼吸下でのナビゲータエコーと心臓同期筋遅延造影MRIにおける画像評価関す研究 
kn-title=Image Evaluation of Free-breathing Navigator Echo and Triggered Cardiac-gated Delayed Myocardial Enhancement Magnetic Resonance Imaging in Sedated Infants
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MatsuuraRyutaro
en-aut-sei=Matsuura
en-aut-mei=Ryutaro
kn-aut-name=松浦龍太郎
kn-aut-sei=松浦
kn-aut-mei=龍太郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=岡山大学大学院保健学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=7
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=201802
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Cell-based Biological Pacemakers: Progress and Problems
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= The number of permanent pacemaker implantations has been increasing due to the aging of populations worldwide and the increase in the numbers of patients with heart diseases. Commercially available mechanical pacemakers are very useful but still have some problems including short battery life, a risk of infection, the absence of physiological autonomic responsiveness, metal allergy, and electronic interference. A biological pacemaker may resolve these problems and regenerate the cardiac pacemaker. Cell-based therapy and gene therapy have been addressed with the goal of solving the challenges of biological pacemaker. However, the clinical application of a biological pacemaker has not yet been realized. Here we discuss the types of cells that can be used for a biological pacemaker and the problems that remain regarding the clinical applications of cell-based therapy.
en-copyright=
kn-copyright=

en-aut-name=SaitoYukihiro
en-aut-sei=Saito
en-aut-mei=Yukihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NakamuraKazufumi
en-aut-sei=Nakamura
en-aut-mei=Kazufumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ItoHiroshi
en-aut-sei=Ito
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Density and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Density and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Density and Pharmaceutical Sciences
kn-affil=
en-keyword=cell therapy
kn-keyword=cell therapy
en-keyword=pluripotent stem cells
kn-keyword=pluripotent stem cells
en-keyword=cardiomyocytes
kn-keyword=cardiomyocytes
en-keyword=biological pacemaker
kn-keyword=biological pacemaker
en-keyword=hyperpolarization activated cyclic nucleotide gated potassium channel 4
kn-keyword=hyperpolarization activated cyclic nucleotide gated potassium channel 4
END

start-ver=1.4
cd-journal=joma
no-vol=52
cd-vols=
no-issue=5
article-no=
start-page=1010
end-page=1017
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=201105
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Therapy for hyperthermia-induced seizures in Scn1a mutant rats
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Purpose: Mutations in the SCN1A gene, which encodes the alpha 1 subunit of voltage-gated sodium channels, cause generalized epilepsy with febrile seizures plus (GEFS+) and severe myoclonic epilepsy of infancy (SMEI). N1417H-Scn1a mutant rats are considered to be an animal model of human FS+ or GEFS+. To assess the pharmacologic validity of this model, we compared the efficacies of eight different antiepileptic drugs (AEDs) for the treatment of hyperthermia-induced seizures using N1417H-Scn1a mutant rats. 

Methods: AEDs used in this study included valproate, carbamazepine (CBZ), phenobarbital, gabapentin, acetazolamide, diazepam (DZP), topiramate, and potassium bromide (KBr). The effects of these AEDs were evaluated using the hot water model, which is a model of experimental FS. Five-week-old rats were pretreated with each AED and immersed in water at 45 degrees C to induce hyperthermia-induced seizures. The seizure manifestations and video-electroencephalographic recordings were evaluated. Furthermore, the effects of each AED on motor coordination and balance were assessed using the balance-beam test. 

Key Findings: KBr significantly reduced seizure durations, and its anticonvulsant effects were comparable to those of DZP. On the other hand, CBZ decreased the seizure threshold. In addition, DZP and not KBr showed significant impairment in motor coordination and balance. 

Significance: DZP and KBr showed potent inhibitory effects against hyperthermia-induced seizures in the Scn1a mutant rats, whereas CBZ exhibited adverse effects. These responses to hyperthermia-induced seizures were similar to those in patients with GEFS+ and SMEI. N1417H-Scn1a mutant rats may, therefore, be useful for testing the efficacy of new AEDs against FS in GEFS+ and SMEI patients.
en-copyright=
kn-copyright=

en-aut-name=HayashiKeiichiro
en-aut-sei=Hayashi
en-aut-mei=Keiichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=UeshimaSatoshi
en-aut-sei=Ueshima
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OuchidaMamoru
en-aut-sei=Ouchida
en-aut-mei=Mamoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MashimoTomoji
en-aut-sei=Mashimo
en-aut-mei=Tomoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NishikiTeiichi
en-aut-sei=Nishiki
en-aut-mei=Teiichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SendoToshiaki
en-aut-sei=Sendo
en-aut-mei=Toshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SerikawaTadao
en-aut-sei=Serikawa
en-aut-mei=Tadao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MatsuiHideki
en-aut-sei=Matsui
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OhmoriIori
en-aut-sei=Ohmori
en-aut-mei=Iori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Physiol

affil-num=2
en-affil=
kn-affil=Okayama Univ Hosp, Dept Pharm

affil-num=3
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Mol Genet

affil-num=4
en-affil=
kn-affil=Kyoto Univ, Grad Sch Med, Inst Lab Anim

affil-num=5
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Physiol

affil-num=6
en-affil=
kn-affil=Okayama Univ Hosp, Dept Pharm

affil-num=7
en-affil=
kn-affil=Kyoto Univ, Grad Sch Med, Inst Lab Anim

affil-num=8
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Physiol

affil-num=9
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Physiol
en-keyword=Febrile seizure
kn-keyword=Febrile seizure
en-keyword=Animal models
kn-keyword=Animal models
en-keyword=Scn1a gene
kn-keyword=Scn1a gene
en-keyword=Generalized epilepsy with febrile seizures plus
kn-keyword=Generalized epilepsy with febrile seizures plus
en-keyword=Severe myoclonic epilepsy of infancy
kn-keyword=Severe myoclonic epilepsy of infancy
END

start-ver=1.4
cd-journal=joma
no-vol=3
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130413
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Electric double-layer capacitance between an ionic liquid and few-layer graphene
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Ionic-liquid gates have a high carrier density due to their atomically thin electric double layer (EDL) and extremely large geometrical capacitance C-g. However, a high carrier density in graphene has not been achieved even with ionic-liquid gates because the EDL capacitance C-EDL between the ionic liquid and graphene involves the series connection of C-g and the quantum capacitance C-q, which is proportional to the density of states. We investigated the variables that determine C-EDL at the molecular level by varying the number of graphene layers n and thereby optimising C-q. The C-EDL value is governed by C-q at n, 4, and by C-g at n > 4. This transition with n indicates a composite nature for C-EDL. Our finding clarifies a universal principle that determines capacitance on a microscopic scale, and provides nanotechnological perspectives on charge accumulation and energy storage using an ultimately thin capacitor.
en-copyright=
kn-copyright=

en-aut-name=UesugiEri
en-aut-sei=Uesugi
en-aut-mei=Eri
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=GotoHidenori
en-aut-sei=Goto
en-aut-mei=Hidenori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=EguchiRitsuko
en-aut-sei=Eguchi
en-aut-mei=Ritsuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=FujiwaraAkihiko
en-aut-sei=Fujiwara
en-aut-mei=Akihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KubozonoYoshihiro
en-aut-sei=Kubozono
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama Univ, Surface Sci Res Lab

affil-num=2
en-affil=
kn-affil=Okayama Univ, Surface Sci Res Lab

affil-num=3
en-affil=
kn-affil=Okayama Univ, Surface Sci Res Lab

affil-num=4
en-affil=
kn-affil=SPring 8, Japan Synchrotron Radiat Res Inst

affil-num=5
en-affil=
kn-affil=Okayama Univ, Surface Sci Res Lab
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=5
article-no=
start-page=369
end-page=376
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=201210
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Dravet Syndrome : A Genetic Epileptic Disorder
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Dravet syndrome (DS), or severe myoclonic epilepsy in infancy, is one of the most severe types of genetic epilepsy. It is characterized by the initial occurrence of febrile or afebrile seizures that often evolve into status epilepticus in infants with normal development, and by the subsequent appearance of myoclonic and/or atypical absence seizures as well as complex partial seizures. The key feature that characterizes DS is fever sensitivity, although photosensitivity and pattern-sensitivity are also often seen. The prognosis is unfavorable in most cases. Seizures become drug-resistant and persist, with many patients suffering from motor and cognitive impairment. Mutations of SCN1A, which encodes the voltage-gated sodium channel NaV1.1, are the most frequent genetic cause of this syndrome. SCN1A mutations and/or microchromosomal rearrangements involving SCN1A are detected in about 85% of patients. Mutations of PCDH19 have also been reported in female patients with clinical findings compatible with DS. PCDH19 mutations might account for 5% of overall DS cases. Thirty years after its first description, DS is considered as a model of channelopathy. This survey reviews recent developments in the research literature on DS, focusing on the clinical course, as well as its genetic causes.
en-copyright=
kn-copyright=

en-aut-name=AkiyamaMari
en-aut-sei=Akiyama
en-aut-mei=Mari
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KobayashiKatsuhiro
en-aut-sei=Kobayashi
en-aut-mei=Katsuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OhtsukaYoko
en-aut-sei=Ohtsuka
en-aut-mei=Yoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, and Okayama University Hospital

affil-num=2
en-affil=
kn-affil=Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, and Okayama University Hospital

affil-num=3
en-affil=
kn-affil=Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, and Okayama University Hospital
en-keyword=Dravet syndrome
kn-keyword=Dravet syndrome
en-keyword=long-term outcome
kn-keyword=long-term outcome
en-keyword=SCN1A
kn-keyword=SCN1A
en-keyword=PCDH19
kn-keyword=PCDH19
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120323
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=空港における飛行機のゲート最適配置問題－計画アルゴリズムとシミュレーションによる接近法
kn-title=The Airport Gate Assignment Problem: Scheduling Algorithms and Simulation Approach
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=Thanyan ALSultanAhmed
en-aut-sei=Thanyan ALSultan
en-aut-mei=Ahmed
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=124
cd-vols=
no-issue=1
article-no=
start-page=67
end-page=70
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Bisphosphonate treatment in osteogenesis imperfecta
kn-title=骨形成不全症の治療
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TanakaHiroyuki
en-aut-sei=Tanaka
en-aut-mei=Hiroyuki
kn-aut-name=田中弘之
kn-aut-sei=田中
kn-aut-mei=弘之
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山済生会総合病院　小児科
en-keyword=ビスフォスフォネート
kn-keyword=ビスフォスフォネート
en-keyword=パミドロネート
kn-keyword=パミドロネート
en-keyword=ゾレドロネート
kn-keyword=ゾレドロネート
en-keyword=骨折
kn-keyword=骨折
en-keyword=コラーゲン
kn-keyword=コラーゲン
END

start-ver=1.4
cd-journal=joma
no-vol=101
cd-vols=
no-issue=1-2
article-no=
start-page=37
end-page=41
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1989
dt-pub=198902
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=CT evaluation of vascular invasion in pancreatic carcinoma
kn-title=CTによる膵癌の大血管浸潤の評価―血管造影所見・手術所見との対比―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A new method of factor analysis has been devised as a dynamic study in nuclear medicine. Instead of whole sequence factor analysis of images, partially-sequenced images of Kr-81m pulmonary ventilation scintigrams, acquired with respiratory-gated signals, were analysed using this method. Incrementing the first and last frame number of the image sequence, the motion of the factor images, was obtained including diaphragmatic images, thoracic images and physiological pathological dead space, during one respiratory cycle. The varying form of the correlation between two factor images over time provided a distinguishable pattern of patients with pathological conditions such as chronic obstructive pulmonary disese from normal subjects.
en-copyright=
kn-copyright=

en-aut-name=HosokawaNobuyuki
en-aut-sei=Hosokawa
en-aut-mei=Nobuyuki
kn-aut-name=細川敦之
kn-aut-sei=細川
kn-aut-mei=敦之
aut-affil-num=1
ORCID=

en-aut-name=TanabeMasatada
en-aut-sei=Tanabe
en-aut-mei=Masatada
kn-aut-name=田邉正忠
kn-aut-sei=田邉
kn-aut-mei=正忠
aut-affil-num=2
ORCID=

en-aut-name=OhkawaMotoomi
en-aut-sei=Ohkawa
en-aut-mei=Motoomi
kn-aut-name=大川元臣
kn-aut-sei=大川
kn-aut-mei=元臣
aut-affil-num=3
ORCID=

en-aut-name=TamaiToyosato
en-aut-sei=Tamai
en-aut-mei=Toyosato
kn-aut-name=玉井豊理
kn-aut-sei=玉井
kn-aut-mei=豊理
aut-affil-num=4
ORCID=

en-aut-name=KojimaKanji
en-aut-sei=Kojima
en-aut-mei=Kanji
kn-aut-name=児島完治
kn-aut-sei=児島
kn-aut-mei=完治
aut-affil-num=5
ORCID=

en-aut-name=KageyamaJunichi
en-aut-sei=Kageyama
en-aut-mei=Junichi
kn-aut-name=影山淳一
kn-aut-sei=影山
kn-aut-mei=淳一
aut-affil-num=6
ORCID=

en-aut-name=TsuuchiYasuhiko
en-aut-sei=Tsuuchi
en-aut-mei=Yasuhiko
kn-aut-name=津内保彦
kn-aut-sei=津内
kn-aut-mei=保彦
aut-affil-num=7
ORCID=

en-aut-name=ToyamaYoshihiro
en-aut-sei=Toyama
en-aut-mei=Yoshihiro
kn-aut-name=外山芳弘
kn-aut-sei=外山
kn-aut-mei=芳弘
aut-affil-num=8
ORCID=

en-aut-name=MoriYasutane
en-aut-sei=Mori
en-aut-mei=Yasutane
kn-aut-name=森泰胤
kn-aut-sei=森
kn-aut-mei=泰胤
aut-affil-num=9
ORCID=

en-aut-name=YodenMidori
en-aut-sei=Yoden
en-aut-mei=Midori
kn-aut-name=余田みどり
kn-aut-sei=余田
kn-aut-mei=みどり
aut-affil-num=10
ORCID=

affil-num=1
en-affil=
kn-affil=香川医科大学放射線医学教室

affil-num=2
en-affil=
kn-affil=香川医科大学放射線医学教室

affil-num=3
en-affil=
kn-affil=香川医科大学放射線医学教室

affil-num=4
en-affil=
kn-affil=香川医科大学放射線医学教室

affil-num=5
en-affil=
kn-affil=香川医科大学放射線医学教室

affil-num=6
en-affil=
kn-affil=香川医科大学放射線医学教室

affil-num=7
en-affil=
kn-affil=香川医科大学放射線医学教室

affil-num=8
en-affil=
kn-affil=香川医科大学放射線医学教室

affil-num=9
en-affil=
kn-affil=香川医科大学放射線医学教室

affil-num=10
en-affil=
kn-affil=香川医科大学放射線医学教室
en-keyword=膵癌
kn-keyword=膵癌
en-keyword=大血管浸潤
kn-keyword=大血管浸潤
en-keyword=CT所見
kn-keyword=CT所見
en-keyword=血管造影所見
kn-keyword=血管造影所見
en-keyword=手術所見
kn-keyword=手術所見
END

start-ver=1.4
cd-journal=joma
no-vol=101
cd-vols=
no-issue=1-2
article-no=
start-page=31
end-page=36
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1989
dt-pub=198902
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Dynamic study of lung ventilation by partial sequence factor analysis
kn-title=Partial Sequence Factor Analysisによる肺機能解析
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A new method of factor analysis has been devised as a dynamic study in nuclear medicine. Instead of whole sequence factor analysis of images, partially-sequenced images of Kr-81m pulmonary ventilation scintigrams, acquired with respiratory-gated signals, were analysed using this method. Incrementing the first and last frame number of the image sequence, the motion of the factor images, was obtained including diaphragmatic images, thoracic images and physiological pathological dead space, during one respiratory cycle. The varying form of the correlation between two factor images over time provided a distinguishable pattern of patients with pathological conditions such as chronic obstructive pulmonary disese from normal subjects.
en-copyright=
kn-copyright=

en-aut-name=TachikawaAkira
en-aut-sei=Tachikawa
en-aut-mei=Akira
kn-aut-name=立川光
kn-aut-sei=立川
kn-aut-mei=光
aut-affil-num=1
ORCID=

en-aut-name=TanabeMasatada
en-aut-sei=Tanabe
en-aut-mei=Masatada
kn-aut-name=田邉正忠
kn-aut-sei=田邉
kn-aut-mei=正忠
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=香川医科大学放射線医学教室

affil-num=2
en-affil=
kn-affil=香川医科大学放射線医学教室
en-keyword=ファクター・アナリシス
kn-keyword=ファクター・アナリシス
en-keyword=(81m)Kr-ガス肺換気シンチ
kn-keyword=(81m)Kr-ガス肺換気シンチ
en-keyword=呼吸同調
kn-keyword=呼吸同調
en-keyword=因子画像
kn-keyword=因子画像
END

start-ver=1.4
cd-journal=joma
no-vol=413
cd-vols=
no-issue=4-6
article-no=
start-page=379
end-page=383
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2005
dt-pub=20050926
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Fabrication of a logic gate circuit based on ambipolar field-effect transistors with thin films of C<sub>60</sub> and pentacene
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>Ambipolar field-effect transistor (FET) devices were fabricated with a heterostructure of C<sub>60</sub> and pentacene, and their p- and n-channel field-effect mobilities were studied as a function of thickness of pentacene thin-films. The observed dependences of the μ values were interpreted in terms of the morphology of the thin films and the band structure of C<sub>60</sub>/pentacene heterostructure. A complementary metal-oxide-semiconductor (CMOS) circuit was fabricated by integration of two ambipolar FETs, aiming at realization of a new CMOS inverter circuit composed of FETs with the same device structure. The gain of 4, the threshold voltage of 85 V, and the complex output characteristics were explained on the basis of the properties of the component FET devices.</p>
en-copyright=
kn-copyright=

en-aut-name=KuwaharaEiji
en-aut-sei=Kuwahara
en-aut-mei=Eiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KusaiHaruka
en-aut-sei=Kusai
en-aut-mei=Haruka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NaganoTakayuki
en-aut-sei=Nagano
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TakayanagiToshio
en-aut-sei=Takayanagi
en-aut-mei=Toshio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KubozonoYoshihiro
en-aut-sei=Kubozono
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Chemistry, Okayama University

affil-num=2
en-affil=
kn-affil=Department of Chemistry, Okayama University

affil-num=3
en-affil=
kn-affil=Department of Chemistry, Okayama University

affil-num=4
en-affil=
kn-affil=Department of Chemistry, Okayama University

affil-num=5
en-affil=
kn-affil=Department of Chemistry, Okayama University
en-keyword=Band structure
kn-keyword=Band structure
en-keyword=Carbon
kn-keyword=Carbon
en-keyword=CMOS integrated circuits
kn-keyword=CMOS integrated circuits
en-keyword=Field effect transistors
kn-keyword=Field effect transistors
en-keyword=Logic gates
kn-keyword=Logic gates
en-keyword=Thin films
kn-keyword=Thin films
en-keyword=Threshold voltage
kn-keyword=Threshold voltage
en-keyword=Band structures
kn-keyword=Band structures
en-keyword=Logic gate circuits
kn-keyword=Logic gate circuits
en-keyword=N-channel field-effective mobilities
kn-keyword=N-channel field-effective mobilities
en-keyword=Pentacene
kn-keyword=Pentacene
en-keyword=Logic circuits
kn-keyword=Logic circuits
END

start-ver=1.4
cd-journal=joma
no-vol=87
cd-vols=
no-issue=14
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2005
dt-pub=200510
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Fabrication of C<sub>60</sub> field-effect transistors with polyimide and Ba<sub>0.4</sub>Sr<sub>0.6</sub>Ti<sub>0.96</sub>O<sub>3</sub> gate insulators
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>Flexible C<sub>60</sub> field-effect transistor (FET) device has been fabricated with polyimide gate insulator on the poly(ethylene terephthalate) substrate, and n-channel normally-off FET properties are observed in this FET device. The field-effect mobility, ?, is estimated to be ~10<sup>-2</sup> cm<sup>2</sup> V<sup>-1</sup> s<sup>-1</sup> at 300 K. Furthermore, the C<sub>60</sub> FET has been fabricated with high dielectric Ba<sub>0.4</sub>Sr<sub>0.6</sub>Ti<sub>0.96</sub>O<sub>3</sub> (BST) gate insulator, showing n-channel properties; the ? value is estimated to be ~10<sup>-4</sup> cm<sup>2</sup> V<sup>-1</sup> s<sup>-1</sup> at 300 K. The FET device operates at very low gate voltage, VG, and low drain-source voltage, VDS. Thus these C<sub>60</sub> FET devices possess flexibility and low-voltage operation characteristic of polyimide and BST gate insulators, respectively.</p>
en-copyright=
kn-copyright=

en-aut-name=KubozonoYoshihiro
en-aut-sei=Kubozono
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NaganoTakayuki
en-aut-sei=Nagano
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HaruyamaYusuke
en-aut-sei=Haruyama
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KuwaharaEiji
en-aut-sei=Kuwahara
en-aut-mei=Eiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TakayanagiToshio
en-aut-sei=Takayanagi
en-aut-mei=Toshio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OchiKenji
en-aut-sei=Ochi
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=FujiwaraAkihiko
en-aut-sei=Fujiwara
en-aut-mei=Akihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University

affil-num=3
en-affil=
kn-affil=Okayama University

affil-num=4
en-affil=
kn-affil=Okayama University

affil-num=5
en-affil=
kn-affil=Okayama University

affil-num=6
en-affil=
kn-affil=Okayama University

affil-num=7
en-affil=
kn-affil=Japan Advanced Institute of Science and Technology
en-keyword=fullerene devices
kn-keyword=fullerene devices
en-keyword=insulated gate field effect transistors
kn-keyword=insulated gate field effect transistors
en-keyword=polymers
kn-keyword=polymers
en-keyword=barium compounds
kn-keyword=barium compounds
en-keyword=strontium compounds
kn-keyword=strontium compounds
en-keyword=dielectric materials
kn-keyword=dielectric materials
END

start-ver=1.4
cd-journal=joma
no-vol=409
cd-vols=
no-issue=4-6
article-no=
start-page=187
end-page=191
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2005
dt-pub=20050630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Fabrication and characterization of field-effect transistor device with C<sub>2v</sub> isomer of Pr@C<sub>82</sub>
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>A field-effect transistor (FET) device was fabricated with thin films of C<sub>2v</sub> isomer of Pr@C<sub>82</sub>. This device apparently showed n-channel normally-on type FET properties, where non-zero current was observed at gate-source voltage of 0 V<sub>GS</sub>, of 0V. Normally off FET properties were observed by subtraction of the non-zero current from the drain current.Thus the normally on properties are ascribed to the high bulk current caused by the small energy gap ≈0.3 eV. The field-effect mobility for this FET was 1.5 x 10<sup>-4</sup> cm<sup>2</sup> V<sup>-1</sup> s<sup>-1</sup> at 320 K, being comparable to those of other endohedral metallofullerene FET devices.</p>
en-copyright=
kn-copyright=

en-aut-name=NaganoTakayuki
en-aut-sei=Nagano
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KuwaharaEiji
en-aut-sei=Kuwahara
en-aut-mei=Eiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TakayanagiToshio
en-aut-sei=Takayanagi
en-aut-mei=Toshio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KubozonoYoshihiro
en-aut-sei=Kubozono
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=FujiwaraAkihiko
en-aut-sei=Fujiwara
en-aut-mei=Akihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Chemistry, Okayama University

affil-num=2
en-affil=
kn-affil=Department of Chemistry, Okayama University

affil-num=3
en-affil=
kn-affil=Department of Chemistry, Okayama University

affil-num=4
en-affil=
kn-affil=Department of Chemistry, Okayama University

affil-num=5
en-affil=
kn-affil=CREST, Japan Science and Technology Agency
en-keyword=Field effect transistors
kn-keyword=Field effect transistors
END

start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=5
article-no=
start-page=835
end-page=841
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1997
dt-pub=19971230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=An active circuit for cancellation of common-mode voltage generated by a PWM inverter
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>This paper proposes an active common-noise canceler (ACC) that is capable of eliminating the common-mode voltage produced by a pulsewidth modulation (PWM) inverter. An emitter follower using complementary transistors and a common-mode transformer are incorporated into the ACC, the design method of which is also presented in detail. Experiments using a prototype ACC, whose design and construction are discussed in this paper, verify its viability and effectiveness in eliminating common-mode voltage in a 3.7 kW induction motor drive using an insulated gate bipolar transistor (IGBT) inverter. Some experimental results show that the ACC makes significant contributions to reducing a ground current and a conducted electromagnetic interference (EMI). In addition, the ACC can prevent an electric shock on a nongrounded motor frame and can suppress motor shaft voltage</p>

en-copyright=
kn-copyright=

en-aut-name=OgasawaraSatoshi
en-aut-sei=Ogasawara
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=AyanoHideki
en-aut-sei=Ayano
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=AkagiHirofumi
en-aut-sei=Akagi
en-aut-mei=Hirofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University

affil-num=3
en-affil=
kn-affil=Okayama University
en-keyword=PWM invertors
kn-keyword=PWM invertors
en-keyword=active networks
kn-keyword=active networks
en-keyword=amplifiers
kn-keyword=amplifiers
en-keyword=electromagnetic compatibility
kn-keyword=electromagnetic compatibility
en-keyword=electromagnetic interference
kn-keyword=electromagnetic interference
en-keyword=induction motor drives
kn-keyword=induction motor drives
en-keyword=insulated gate bipolar transistors
kn-keyword=insulated gate bipolar transistors
en-keyword=interference suppression
kn-keyword=interference suppression
END

start-ver=1.4
cd-journal=joma
no-vol=2
cd-vols=
no-issue=
article-no=
start-page=1235
end-page=1241
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1996
dt-pub=199610
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Control and performance of a zero-current-switched three-phase inverter equipped with resonant circuits on the AC-side
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>This paper presents a zero-current-switched voltage-fed inverter equipped with resonant circuits on the AC side. The current flowing through a switching device, i.e., an IGBT is a sum of the load current and the resonant current. If the amplitude of the resonant current is larger than that of the load current, the current in a switching device becomes zero at an instant in each resonant cycle. This allows the switching device to be turned on or off at the zero current. The zero-current-switching makes a significant contribution to reduction of switching losses and electromagnetic noises. In this paper, the principle of zero-current-switching operation, and a novel control scheme are described from a theoretical and practical point of view. Experimental results obtained from a laboratory system of 5 kVA verify the practicability. Moreover, the efficiency and losses of the proposed soft-switched inverter are compared with those of a hard-switched inverter </p>

en-copyright=
kn-copyright=

en-aut-name=FujitaHideaki
en-aut-sei=Fujita
en-aut-mei=Hideaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OgasawaraSatoshi
en-aut-sei=Ogasawara
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=AkagiHirofumi
en-aut-sei=Akagi
en-aut-mei=Hirofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University

affil-num=3
en-affil=
kn-affil=Okayama University
en-keyword=electric current control
kn-keyword=electric current control
en-keyword=electromagnetic interference
kn-keyword=electromagnetic interference
en-keyword=insulated gate bipolar transistors
kn-keyword=insulated gate bipolar transistors
en-keyword=invertors
kn-keyword=invertors
en-keyword=losses
kn-keyword=losses
en-keyword=power semiconductor switches
kn-keyword=power semiconductor switches
en-keyword=switching circuits
kn-keyword=switching circuits
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=417
end-page=422
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=200211
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=CMOS floating gate defect detection using I/sub DDQ/ test with DC power supply superposed by AC component
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>In this paper, we propose a new I/sub DDQ/ test method for detecting floating gate defects in CMOS ICs. In the method, an unusual increase of the supply current, caused by defects, is promoted by superposing an AC component on the DC power supply. The feasibility of the test is examined by some experiments on four DUTs with an intentionally caused defect. The results showed that our method could detect clearly all the defects, one of which may be detected by neither any functional logic test nor any conventional I/sub DDQ/ test.</p>

en-copyright=
kn-copyright=

en-aut-name=MichinishiHiroyuki
en-aut-sei=Michinishi
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YokohiraTokumi
en-aut-sei=Yokohira
en-aut-mei=Tokumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OkamotoTakuji
en-aut-sei=Okamoto
en-aut-mei=Takuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KobayashiToshifumi
en-aut-sei=Kobayashi
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HondoTsutomu
en-aut-sei=Hondo
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University of Science

affil-num=2
en-affil=
kn-affil=Okayama University

affil-num=3
en-affil=
kn-affil=Okayama University of Science

affil-num=4
en-affil=
kn-affil=Mitsubishi Electric Company Limited

affil-num=5
en-affil=
kn-affil=Sharp Takaya Electronics Industry Company Limited
en-keyword=CMOS logic circuits
kn-keyword=CMOS logic circuits
en-keyword=electric current measurement
kn-keyword=electric current measurement
en-keyword=integrated circuit testing
kn-keyword=integrated circuit testing
en-keyword=logic testing
kn-keyword=logic testing
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=68
end-page=74
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1996
dt-pub=199611
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A test methodology for interconnect structures of LUT-based FPGAs
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>In this paper we consider testing for programmable interconnect structures of look-up table based FPGAs. The interconnect structure considered in the paper consists of interconnecting wires and programmable points (switches) to join them. As fault models, stuck-at faults of the wires, and extra-device faults and missing-device faults of the programmable points are considered. We heuristically derive test procedures for the faults and then show their validness and complexity</p>

en-copyright=
kn-copyright=

en-aut-name=MichinishiHiroyuki
en-aut-sei=Michinishi
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YokohiraTokumi
en-aut-sei=Yokohira
en-aut-mei=Tokumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OkamotoTakuji
en-aut-sei=Okamoto
en-aut-mei=Takuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=InoueTomoo
en-aut-sei=Inoue
en-aut-mei=Tomoo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=FujiwaraHideo
en-aut-sei=Fujiwara
en-aut-mei=Hideo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University

affil-num=3
en-affil=
kn-affil=Okayama University

affil-num=4
en-affil=
kn-affil=Nara Institute of Science and Technology

affil-num=5
en-affil=
kn-affil=Nara Institute of Science and Technology
en-keyword=SRAM chips
kn-keyword=SRAM chips
en-keyword=automatic testing
kn-keyword=automatic testing
en-keyword=design for testability
kn-keyword=design for testability
en-keyword=fault diagnosis
kn-keyword=fault diagnosis
en-keyword=field programmable gate arrays
kn-keyword=field programmable gate arrays
en-keyword=integrated circuit interconnections
kn-keyword=integrated circuit interconnections
en-keyword=logic testing
kn-keyword=logic testing
en-keyword=reconfigurable architectures
kn-keyword=reconfigurable architectures
en-keyword=sequential circuits
kn-keyword=sequential circuits
en-keyword=table lookup
kn-keyword=table lookup
END

start-ver=1.4
cd-journal=joma
no-vol=2
cd-vols=
no-issue=
article-no=
start-page=928
end-page=933
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2000
dt-pub=20006
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Analysis and reduction of EMI conducted by a PWM inverter-fed AC motor drive system having long power cables
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>This paper analyzes conducted EMI generated by a PWM inverter-fed induction motor drive system. It is shown experimentally and analytically that resonant phenomena in a high-frequency range beyond a dominant resonant frequency are originated from the behavior of power cables as a distributed-constant circuit. Spectra of common-mode and differential-mode currents are simulated by means of introducing a distributed-constant model of the power cables, which consists of a 20-step ladder circuit. As a result, it is also shown that these resonances can be damped out by a single common-mode transformer (CMT) and three differential-mode filters (DMFs), both of which have been proposed by the authors</p>

en-copyright=
kn-copyright=

en-aut-name=OgasawaraSatoshi
en-aut-sei=Ogasawara
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=AkagiHirofumi
en-aut-sei=Akagi
en-aut-mei=Hirofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Tokyo Institute of Technology
en-keyword=DC-AC power convertors
kn-keyword=DC-AC power convertors
en-keyword=PWM invertors
kn-keyword=PWM invertors
en-keyword=bipolar transistor switches
kn-keyword=bipolar transistor switches
en-keyword=electromagnetic interference
kn-keyword=electromagnetic interference
en-keyword=induction motor drives
kn-keyword=induction motor drives
en-keyword=insulated gate bipolar transistors
kn-keyword=insulated gate bipolar transistors
en-keyword=ladder networks
kn-keyword=ladder networks
en-keyword=power bipolar transistors
kn-keyword=power bipolar transistors
en-keyword=power cables
kn-keyword=power cables
en-keyword=power semiconductor switches
kn-keyword=power semiconductor switches
en-keyword=power transformers
kn-keyword=power transformers
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=406
end-page=409
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2003
dt-pub=200311
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Improvement of detectability for CMOS floating gate defects in supply current test
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>We already proposed a supply current test method for detecting floating gate defects in CMOS ICs. In the method, increase of the supply current caused by defects is promoted by superposing a sinusoidal signal on the supply voltage. In this study, we propose one way to improve detectability of the method for the defects. They are detected by analyzing the frequency of supply current and judging whether secondary harmonics of the sinusoidal signal exist or not. Effectiveness of our way is confirmed by some experiments.</p>

en-copyright=
kn-copyright=

en-aut-name=MichinishiHiroyuki
en-aut-sei=Michinishi
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YokohiraTokumi
en-aut-sei=Yokohira
en-aut-mei=Tokumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OkamotoTakuji
en-aut-sei=Okamoto
en-aut-mei=Takuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KobayashiToshifumi
en-aut-sei=Kobayashi
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HondoTsutomu
en-aut-sei=Hondo
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University of Science

affil-num=2
en-affil=
kn-affil=Okayama University

affil-num=3
en-affil=
kn-affil=Okayama University of Science

affil-num=4
en-affil=
kn-affil=Mitsubishi Electric Company Limited

affil-num=5
en-affil=
kn-affil=Sharp Takaya Electronics Industry Company Limited
en-keyword=CMOS logic circuits
kn-keyword=CMOS logic circuits
en-keyword=built-in self test
kn-keyword=built-in self test
en-keyword=equivalent circuits
kn-keyword=equivalent circuits
en-keyword=integrated circuit testing
kn-keyword=integrated circuit testing
en-keyword=logic testing
kn-keyword=logic testing
END

start-ver=1.4
cd-journal=joma
no-vol=2
cd-vols=
no-issue=
article-no=
start-page=1547
end-page=1533
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1997
dt-pub=19976
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=An active circuit for cancellation of common-mode voltage generated by a PWM inverter
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>This paper proposes an “active common-noise canceler (ACC)” that is capable of eliminating the common-mode voltage produced by a PWM inverter. An emitter follower using complementary transistors and a common-mode transformer are incorporated into the ACC, the design method of which is also presented in detail. A prototype ACC designed and constructed in this paper verifies the viability and effectiveness in a 3.7 kW induction motor drive using an IGBT inverter. Some experimental results show that the ACC makes significant contributions to reducing ground current and conducted EMI. In addition, the ACC can prevent electric shock on a ungrounded motor frame and can suppress motor shaft voltage</p>

en-copyright=
kn-copyright=

en-aut-name=OgasawaraSatoshi
en-aut-sei=Ogasawara
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=AyanoHideki
en-aut-sei=Ayano
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=AkagiHirofumi
en-aut-sei=Akagi
en-aut-mei=Hirofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University

affil-num=3
en-affil=
kn-affil=Okayama University
en-keyword=DC-AC power convertors
kn-keyword=DC-AC power convertors
en-keyword=PWM invertors
kn-keyword=PWM invertors
en-keyword=active networks
kn-keyword=active networks
en-keyword=bipolar transistor switches
kn-keyword=bipolar transistor switches
en-keyword=electromagnetic compatibility
kn-keyword=electromagnetic compatibility
en-keyword=electromagnetic interference
kn-keyword=electromagnetic interference
en-keyword=insulated gate bipolar transistors
kn-keyword=insulated gate bipolar transistors
en-keyword=power bipolar transistors
kn-keyword=power bipolar transistors
en-keyword=power semiconductor switches
kn-keyword=power semiconductor switches
en-keyword=power transformers
kn-keyword=power transformers
en-keyword=switching circuits
kn-keyword=switching circuits
END

start-ver=1.4
cd-journal=joma
no-vol=133
cd-vols=
no-issue=2
article-no=
start-page=538
end-page=542
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=20080812
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Analysis of response mechanism of a proton-pumping gate FET hydrogen gas sensor in air
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>Two different types of hydrogen response signals (DC and AC) of a proton-pumping gate FET with triple layer gate structure (Pd/proton conducting polymer/Pt) were obtained. The proton-pumping gate FET showed good selectivity against other gases (CH<sub>4</sub>, C<sub>2</sub>H<sub>6</sub>, NH<sub>3</sub>, and O<sub>2</sub>). For practical use, the hydrogen response characteristics of the proton-pumping gate FET were investigated in air (a gaseous mixture of oxygen and nitrogen). The proton-pumping gate FET showed different hydrogen response characteristics in nitrogen as well as in air, despite the lack of oxygen interference independently. To clarify the response mechanism of the proton-pumping gate FET, a hydrogen response measurement was performed, using a gas flow system and electrochemical impedance spectroscopy. Consequently, the difference in response between nitrogen and air was found to be due to the hydrogen dissociation reaction and the interference with the proton transfer caused by the adsorbed oxygen on the upper Pd gate electrode</p>
en-copyright=
kn-copyright=

en-aut-name=YamaguchiTomiharu
en-aut-sei=Yamaguchi
en-aut-mei=Tomiharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TakisawaMasanori
en-aut-sei=Takisawa
en-aut-mei=Masanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KiwaToshihiko
en-aut-sei=Kiwa
en-aut-mei=Toshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YamadaHironobu
en-aut-sei=Yamada
en-aut-mei=Hironobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TsukadaKeiji
en-aut-sei=Tsukada
en-aut-mei=Keiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University

affil-num=3
en-affil=
kn-affil=Department of Electrical and Electronic Engineering, Okayama University

affil-num=4
en-affil=
kn-affil=Department of Electrical and Electronic Engineering, Okayama University

affil-num=5
en-affil=
kn-affil=Department of Electrical and Electronic Engineering, Okayama University
en-keyword=Field effect transistor (FET)
kn-keyword=Field effect transistor (FET)
en-keyword=Hydrogen sensor
kn-keyword=Hydrogen sensor
en-keyword=Proton-pumping gate
kn-keyword=Proton-pumping gate
en-keyword=Oxygen
kn-keyword=Oxygen
en-keyword=Electrochemical impedance spectroscopy (EIS)
kn-keyword=Electrochemical impedance spectroscopy (EIS)
END

start-ver=1.4
cd-journal=joma
no-vol=2
cd-vols=
no-issue=
article-no=
start-page=409
end-page=416
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1997
dt-pub=199711
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Utility applications of power electronics in Japan
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>Since the late 1950s, power electronics has been developing by leaps and bounds without saturation into the key technology essential to modern society and human life, as well as to electrical engineering. This paper is focused on utility applications of power electronics technology in Japan, and on the state of the art of power semiconductor devices for high power applications. For instance, attention is paid to a ±500 kV, 2.8 GW high-voltage DC transmission system under construction, and to 8 kV, 3.5 kA light-triggered thyristors used for constituting its thyristor valves. This paper also presents future prospects and directions of power electronics technology in the 21st century, including the personal views and expectations of the author</p>

en-copyright=
kn-copyright=

en-aut-name=AkagiHirofumi
en-aut-sei=Akagi
en-aut-mei=Hirofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University
en-keyword=HVDC power transmission
kn-keyword=HVDC power transmission
en-keyword=active filters
kn-keyword=active filters
en-keyword=distribution networks
kn-keyword=distribution networks
en-keyword=electricity supply industry
kn-keyword=electricity supply industry
en-keyword=hydroelectric generators
kn-keyword=hydroelectric generators
en-keyword=insulated gate bipolar transistors
kn-keyword=insulated gate bipolar transistors
en-keyword=power electronics
kn-keyword=power electronics
en-keyword=pumped-storage power stations
kn-keyword=pumped-storage power stations
en-keyword=thyristor applications
kn-keyword=thyristor applications
en-keyword=variable speed gear
kn-keyword=variable speed gear
END

start-ver=1.4
cd-journal=joma
no-vol=57
cd-vols=
no-issue=5
article-no=
start-page=257
end-page=260
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2003
dt-pub=200310
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A simple method for screening photoelectric dyes towards their use for retinal prostheses.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>Photoelectric dyes absorb light and convert photon energy to electric potentials. To test whether these dyes could be used for retinal prostheses, a simple in vitro screening system was developed. Retinal neurons were cultured from the eyes of chick embryos at the 10-day embryonic stage, at which time no retinal photoreceptor cells have yet developed. Intracellular calcium elevation was observed with Fluo-4 in cultured retinal neurons before and after photoelectric dye was applied at varying concentrations to the culture medium. Five of 7 photoelectric dyes tested in this in vitro system induced intracellular calcium elevation in cultured chick retinal neurons. The intracellular calcium elevation generated by the 5 photoelectric dyes was blocked by extracellular calcium depletion in the case of all 5 dyes, and, except for one dye, by the presence of voltage-gated calcium channel blockers. The photoelectric dyes absorbed light under an inverted microscope and stimulated retinal neurons. This simple in vitro system allows the screening of photoelectric dyes which can be used for retinal prostheses.</p>

en-copyright=
kn-copyright=

en-aut-name=MatsuoToshihiko
en-aut-sei=Matsuo
en-aut-mei=Toshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University
en-keyword=photoelectric dye (pigment)
kn-keyword=photoelectric dye (pigment)
en-keyword=chick retinal neurons
kn-keyword=chick retinal neurons
en-keyword=intracellular calcium
kn-keyword=intracellular calcium
en-keyword=retinal prostheses
kn-keyword=retinal prostheses
en-keyword=retinal implant
kn-keyword=retinal implant
END

start-ver=1.4
cd-journal=joma
no-vol=35
cd-vols=
no-issue=5
article-no=
start-page=307
end-page=317
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1981
dt-pub=198111
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Inhibition of anaphylactic histamine release from heterologously sensitized mast cells: differential effects of drugs which interfere with calcium influx.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>Drug effects were studied on anaphylactic histamine release from rat mast cells sensitized in vitro with mouse IgE antibody. When histamine release was elicited by adding Ca-++ at various times after antigen-stimulation of sensitized cells in Ca++-free medium, the drugs to be tested were added shortly before each Ca++ addition. Quercetin was effective only when added before or immediately after antigen. Theophylline and disodium cromoglycate (DSCG) were active irrespective of the time interval between antigen and Ca++ addition. Verapamil was more effective when added before or simultaneously with antigen than when added later. When tested in the two-stage experiments, quercetin showed inhibition only in Stage 1 and verapamil was inhibitive primarily in Stage 1, while theophylline and DSCG wee only inhibitive in Stage 2. It seems that quercetin selectively and verapamil primarily act to block calcium-gate opening resulting from antigen-antibody interaction on the mast cell membrane, while theophylline and DSCG selectively inhibit the passage of calcium through open calcium channels.</p>

en-copyright=
kn-copyright=

en-aut-name=KuroseMasao
en-aut-sei=Kurose
en-aut-mei=Masao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University
en-keyword=histamine release
kn-keyword=histamine release
en-keyword=quercetin
kn-keyword=quercetin
en-keyword=disodium cromoglycate
kn-keyword=disodium cromoglycate
en-keyword=theophylline
kn-keyword=theophylline
en-keyword= verapamil.
kn-keyword= verapamil.
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=242
end-page=247
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1997
dt-pub=19971117
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Testing for the programming circuit of LUT-based FPGAs
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>The programming circuit of look-up table based FPGAs consists of two shift registers, a control circuit and a configuration memory (SRAM) cell array. Because the configuration memory cell array can be easily tested by conventional test methods for RAMs, we focus on testing for the shift registers. We show that the testing can be done by using only the faculties of the programming circuit, without using additional hardware</p>

en-copyright=
kn-copyright=

en-aut-name=MichinishiHiroyuki
en-aut-sei=Michinishi
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YokohiraTokumi
en-aut-sei=Yokohira
en-aut-mei=Tokumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OkamotoTakuji
en-aut-sei=Okamoto
en-aut-mei=Takuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=InoueTomoo
en-aut-sei=Inoue
en-aut-mei=Tomoo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=FujiwaraHideo
en-aut-sei=Fujiwara
en-aut-mei=Hideo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University

affil-num=3
en-affil=
kn-affil=Okayama University

affil-num=4
en-affil=
kn-affil=Nara Institute of Science and Technology

affil-num=5
en-affil=
kn-affil=Nara Institute of Science and Technology
en-keyword=SRAM chips
kn-keyword=SRAM chips
en-keyword=field programmable gate arrays
kn-keyword=field programmable gate arrays
en-keyword=logic CAD
kn-keyword=logic CAD
en-keyword=logic testing
kn-keyword=logic testing
en-keyword=shift registers
kn-keyword=shift registers
en-keyword=table lookup
kn-keyword=table lookup
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=68
end-page=74
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1996
dt-pub=199611
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A test methodology for interconnect structures of LUT-based FPGAs
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>In this paper we consider testing for programmable interconnect structures of look-up table based FPGAs. The interconnect structure considered in the paper consists of interconnecting wires and programmable points (switches) to join them. As fault models, stuck-at faults of the wires, and extra-device faults and missing-device faults of the programmable points are considered. We heuristically derive test procedures for the faults and then show their validness and complexity</p>

en-copyright=
kn-copyright=

en-aut-name=MichinishiHiroyuki
en-aut-sei=Michinishi
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YokohiraTokumi
en-aut-sei=Yokohira
en-aut-mei=Tokumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OkamotoTakuji
en-aut-sei=Okamoto
en-aut-mei=Takuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=InoueTomoo
en-aut-sei=Inoue
en-aut-mei=Tomoo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=FujiwaraHideo
en-aut-sei=Fujiwara
en-aut-mei=Hideo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University

affil-num=3
en-affil=
kn-affil=Okayama University

affil-num=4
en-affil=
kn-affil=Nara Institute of Science and Technology

affil-num=5
en-affil=
kn-affil=Nara Institute of Science and Technology
en-keyword=SRAM chips
kn-keyword=SRAM chips
en-keyword=automatic testing
kn-keyword=automatic testing
en-keyword=design for testability
kn-keyword=design for testability
en-keyword=fault diagnosis
kn-keyword=fault diagnosis
en-keyword=field programmable gate arrays
kn-keyword=field programmable gate arrays
en-keyword=integrated circuit interconnections
kn-keyword=integrated circuit interconnections
en-keyword=logic testing
kn-keyword=logic testing
en-keyword=reconfigurable architectures
kn-keyword=reconfigurable architectures
en-keyword=sequential circuits
kn-keyword=sequential circuits
en-keyword=table lookup
kn-keyword=table lookup
END

start-ver=1.4
cd-journal=joma
no-vol=2009
cd-vols=
no-issue=1
article-no=
start-page=170
end-page=175
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20091110
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Proposal for Town Development in Aged Society
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=According to the Aged day commemorative report issued in September of 2007 from the Ministry of Internal Affairs and Communication, the population of over sixty five years old attained the historical record high of 27.44 million or 21.5% of total population. On the other hand, the many of shopping malls with large parking have been located in suburbs with expanding of suburban residential area and the effect of motorization. In addition, the growth of remote shopping such as internet and catalog one, helps accelerate the decline of old shopping malls. However, these malls give the only one life-line to the elder and disabled population. In this paper, we discuss on the way of maintaining this life-line for elder and disabled one from the study of questionnaire surveys for visitors of two shopping mall in Wakamatsu-ward and Tobata-ward, Kitakyushu, the gate way city to Kitakyushu in Fukuoka Prefecture. Some of methodology is proposed to facilitate
revitalization of local areas as the result of this study.
en-copyright=
kn-copyright=

en-aut-name=MatsuoTetsuko
en-aut-sei=Matsuo
en-aut-mei=Tetsuko
kn-aut-name=松尾哲子
kn-aut-sei=松尾
kn-aut-mei=哲子
aut-affil-num=1
ORCID=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=88
cd-vols=
no-issue=1-2
article-no=
start-page=83
end-page=88
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1976
dt-pub=19760228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The fine distribution of lymph vessels in the aortic wall
kn-title=イエウサギの大動脈壁におけるリンパ管の微細分布
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=With adult rabbit under nembutal anesthesia they were subjected to laparotomy, and after ligating chylus about 10ml of India ink diluted 4-fold with physiological saline solution was injected slowly into inguinal lymph nodes and external iliacal lymph nodes. About 5 hours later the abdominal aorta was taken out, and it was cut into longitudinal and cross celloidin sections of about 100μ in thickness, which were stained with aldehyde-fuchsin or light-green solution and the distribution of lymph vessels in the arterial wall was observed. With some of the above specimens transparent samples were also prepared. By the forced reverse flow of lymph it was found that the excretory lymph vessel group arising from lymph capillary immediately adjacent to the internal elastic membrane of the aortic wall runs gradually along collagenous fibers through the fenestrations of each elastic membrane of the tunica media, and appears at the tunica adventitia and after confluencing they become a ralatively large excretory lymph vessel, but they further confluence with the excretory lymph vessel arising from the lymph capillary of fat tissue in the tunica adventitia, and they form an aggregative lymph vessel which runs over the exterior layer of the tunica adventitia, and when it comes out of the tunica adventitia it enters into the aortic lymph node.
What is noteworthy is the fact that both the aggregative and excretory lymph vessels have peri-lymphvessel spaces. Embryologically, such a peri-lymphvessel space is a kind of closed space formed by the peri-arterialwall connective tissue consistig of double membrane that covers a part of the aortic lymph nodes to make an aggregative lymph vessel, and then excretory lymph vessel, which should be considered as a lymph space. Further at the site where the aggregative lymph vessel come in this closed space there is a narrow gate.
en-copyright=
kn-copyright=

en-aut-name=SuwaKiichi
en-aut-sei=Suwa
en-aut-mei=Kiichi
kn-aut-name=諏訪喜一
kn-aut-sei=諏訪
kn-aut-mei=喜一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一解剖学教室
END

start-ver=1.4
cd-journal=joma
no-vol=121
cd-vols=
no-issue=3
article-no=
start-page=149
end-page=156
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20091201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A CACNB4 mutation showing altered Ca(v)2.1 function in a patient with Dravet syndrome
kn-title=Dravet 症候群患者に認められたカルシウムチャネル　機能異常を引き起こす CACNB4 遺伝子変異
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OhmoriIori
en-aut-sei=Ohmori
en-aut-mei=Iori
kn-aut-name=大守伊織
kn-aut-sei=大守
kn-aut-mei=伊織
aut-affil-num=1
ORCID=

en-aut-name=OuchidaMamoru
en-aut-sei=Ouchida
en-aut-mei=Mamoru
kn-aut-name=大内田守
kn-aut-sei=大内田
kn-aut-mei=守
aut-affil-num=2
ORCID=

en-aut-name=MimakiNobuyoshi
en-aut-sei=Mimaki
en-aut-mei=Nobuyoshi
kn-aut-name=御牧信義
kn-aut-sei=御牧
kn-aut-mei=信義
aut-affil-num=3
ORCID=

en-aut-name=NishikiTeiichi
en-aut-sei=Nishiki
en-aut-mei=Teiichi
kn-aut-name=西木禎一
kn-aut-sei=西木
kn-aut-mei=禎一
aut-affil-num=4
ORCID=

en-aut-name=TomizawaKazuhito
en-aut-sei=Tomizawa
en-aut-mei=Kazuhito
kn-aut-name=富澤一仁
kn-aut-sei=富澤
kn-aut-mei=一仁
aut-affil-num=5
ORCID=

en-aut-name=MatsuiHideki
en-aut-sei=Matsui
en-aut-mei=Hideki
kn-aut-name=松井秀樹
kn-aut-sei=松井
kn-aut-mei=秀樹
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　細胞生理学

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　分子遺伝学

affil-num=3
en-affil=
kn-affil=倉敷成人病センター　小児科

affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　細胞生理学

affil-num=5
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　細胞生理学

affil-num=6
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　細胞生理学
en-keyword=てんかん
kn-keyword=てんかん
en-keyword=Dravet 症候群
kn-keyword=Dravet 症候群
en-keyword=CACNB4遺伝子
kn-keyword=CACNB4遺伝子
en-keyword=SCN1A 遺伝子
kn-keyword=SCN1A 遺伝子
END

start-ver=1.4
cd-journal=joma
no-vol=91
cd-vols=
no-issue=7-8
article-no=
start-page=837
end-page=846
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19790830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Physiological research into fundamental touch in piano playing Part 2. Equipment for analyzing and measuring the intensity of the swing-stroke
kn-title=ピアノ奏法における基本的タッチの生理学的研究 第2編 特に打鍵強度分析装置に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This paper describes instruments designed to measure the tone-volume of the piano. The tone-volume depends on the amount of kinetic energy which the player spends on striking the key. The kinetic energy is in direct proportion to the mass set in motion and is the square of the velocity. The mass set is always constant and the energy depends only upon the velocity of the hammer. Thus it is possible to analyze the tone-volume by measuring the velocity of the hammer. Electronic digital devices generally have great advantages over analog ones in the field of physical measurement. The velocity is converted to the time interval by photo-transistors and flip-flop. The signal opens the gate, through which flows a clock pulse of 100KHz. This is transmitted to an electronic pulse counter consisting of 4 decimal counting units. The number of pulses counted by this counter is proportional to the inverse of the velocity, and is compared with 5 preset values to activate one of 6 magnetic counters. Each magnetic counter indicates the number of the swing-stroke, of which the velocity belongs to a previously classified group. This equipment makes it possible to measure the intensity of the tone and its distribution precisely. A velocity of 10m/sec. corresponds to an "ff" tone, with a precision of about 1.25%. The precision increase with decrease of the tone-volume.
en-copyright=
kn-copyright=

en-aut-name=KatayamaSho
en-aut-sei=Katayama
en-aut-mei=Sho
kn-aut-name=片山昭
kn-aut-sei=片山
kn-aut-mei=昭
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一生理学教室
en-keyword=ピアノ奏法の生理学的研究
kn-keyword=ピアノ奏法の生理学的研究
END

start-ver=1.4
cd-journal=joma
no-vol=91
cd-vols=
no-issue=7-8
article-no=
start-page=831
end-page=835
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19790830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Physiological research into fundamental touch in piano playing Part 1. Development of equipment for measuring and analyzing the intensity of the swing-stroke and the time interval
kn-title=ピアノ奏法における基本的タッチの生理学的研究 第1編 打鍵強度および間隔の測定分析装置の開発
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This paper deals with the design of instruments for measurement of the strength of the swing-stroke in piano playing. The strength can be measured by the velocity of the hammer. This is easily detected by a photo-sensitive transistor, and is suitable for digital electronic notation. The velocity is converted to the time interval by photo-transistors and flip-flop. The signal opens a gate, through which flows a clock pulse of 100KHz. This is transmitted to an electronic, pulse counter consisting of 4 decimal counting units. The number of pulses counted by this counter is proportional to the inverse of the velocity, and is compared with 5 present values to activate one of 6 magnetic counters. Each magnetic counter indicates the number of the swing-stroke, of which the velocity belongs to a previously calssified group. This equipment makes it possible to measure the intensity of the tone and its distribution precisely.
en-copyright=
kn-copyright=

en-aut-name=KatayamaSho
en-aut-sei=Katayama
en-aut-mei=Sho
kn-aut-name=片山昭
kn-aut-sei=片山
kn-aut-mei=昭
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一生理学教室
en-keyword=ピアノ奏法の生理学的研究
kn-keyword=ピアノ奏法の生理学的研究
END

start-ver=1.4
cd-journal=joma
no-vol=100
cd-vols=
no-issue=11-12
article-no=
start-page=1113
end-page=1116
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1988
dt-pub=1988
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Factor analysis of gated pulmonary ventilation study with Kr-81m gas in normal volunteers
kn-title=呼吸同調装置による(81m)Kr-ガス持続吸入シンチグラフィのfactor analysis―正常者の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Factor analysis of the steady state breathing cycle using Kr-81m gas wa performed in 7 normal volunteers. Two-factor analysis showed diaphragmatic and thoracic components, including the large airway space component. The contribution of the former was 19.2%±2.1% SD, and the contribution of the latter was 80.2%±2.1% SD. Three-factor analysis showed diaphragmatic (14.3% ±3.3% SD), thoracic (55.7% ±2.1% SD) and large airway space (29.5% ±12.1% SD) components. Factor analysis of dynamic structures appears to be a very useful method for the study of lung ventilation.
en-copyright=
kn-copyright=

en-aut-name=TanabeMasatada
en-aut-sei=Tanabe
en-aut-mei=Masatada
kn-aut-name=田邉正忠
kn-aut-sei=田邉
kn-aut-mei=正忠
aut-affil-num=1
ORCID=

en-aut-name=KawaseYoshiroh
en-aut-sei=Kawase
en-aut-mei=Yoshiroh
kn-aut-name=川瀬良郎
kn-aut-sei=川瀬
kn-aut-mei=良郎
aut-affil-num=2
ORCID=

en-aut-name=SeoHiroyuki
en-aut-sei=Seo
en-aut-mei=Hiroyuki
kn-aut-name=瀬尾裕之
kn-aut-sei=瀬尾
kn-aut-mei=裕之
aut-affil-num=3
ORCID=

en-aut-name=SatohKatashi
en-aut-sei=Satoh
en-aut-mei=Katashi
kn-aut-name=佐藤功
kn-aut-sei=佐藤
kn-aut-mei=功
aut-affil-num=4
ORCID=

en-aut-name=HosokawaNobuyuki
en-aut-sei=Hosokawa
en-aut-mei=Nobuyuki
kn-aut-name=細川敦之
kn-aut-sei=細川
kn-aut-mei=敦之
aut-affil-num=5
ORCID=

en-aut-name=MiyamotoTsutomu
en-aut-sei=Miyamoto
en-aut-mei=Tsutomu
kn-aut-name=宮本勉
kn-aut-sei=宮本
kn-aut-mei=勉
aut-affil-num=6
ORCID=

en-aut-name=MatsunoShinsuke
en-aut-sei=Matsuno
en-aut-mei=Shinsuke
kn-aut-name=松野慎介
kn-aut-sei=松野
kn-aut-mei=慎介
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=香川医科大学放射線医学教室

affil-num=2
en-affil=
kn-affil=香川医科大学放射線医学教室

affil-num=3
en-affil=
kn-affil=香川医科大学放射線医学教室

affil-num=4
en-affil=
kn-affil=香川医科大学放射線医学教室

affil-num=5
en-affil=
kn-affil=香川医科大学放射線医学教室

affil-num=6
en-affil=
kn-affil=香川医科大学放射線医学教室

affil-num=7
en-affil=
kn-affil=香川医科大学放射線医学教室
en-keyword=(81m)Kr-ガス
kn-keyword=(81m)Kr-ガス
en-keyword=factor analysis
kn-keyword=factor analysis
en-keyword=ventilation study
kn-keyword=ventilation study
en-keyword=正常者
kn-keyword=正常者
END

start-ver=1.4
cd-journal=joma
no-vol=100
cd-vols=
no-issue=11-12
article-no=
start-page=1095
end-page=1099
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1988
dt-pub=1988
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=An experimental device for dynamic ventilation imaging
kn-title=換気シンチグラフィ用呼吸同調装置の試作
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To obtain gated respiratory cycle imaging, we made an experimental device in which siglals of the respiratory cycle are monitored with a thermistor. The signals of the respiratory cycle are utilized to reconstruct pulmonary dynamic images in multiple sequential frames. Application of this device adds the dimension of time to the resolution of regional ventilation. The device has the potential for separating tidal and residual components, and way be useful for studying the pathophysiologic aspects of regional ventilation.
en-copyright=
kn-copyright=

en-aut-name=TanabeMasatada
en-aut-sei=Tanabe
en-aut-mei=Masatada
kn-aut-name=田邉正忠
kn-aut-sei=田邉
kn-aut-mei=正忠
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=香川医科大学放射線医学教室
en-keyword=換気シンチグラフィ
kn-keyword=換気シンチグラフィ
en-keyword=呼吸同調装置
kn-keyword=呼吸同調装置
END

start-ver=1.4
cd-journal=joma
no-vol=99
cd-vols=
no-issue=9-10
article-no=
start-page=1071
end-page=1081
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1987
dt-pub=19871031
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Chronic effects of the Ca(++) channel blocker verapamil on monoamine release and metabolism in discrete rat brain regions: Comparison with the effects of methamphetamine and reserpine
kn-title=カルシウムチャンネル阻害剤verapamilの中枢モノアミン伝達物質の放出ならびに代謝に及ぼす作用 : methamphetamineおよびreserpineとの比較
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The effects of chronic treatment with verapamil(VP) on monoamine release and metabolism in rat brain in vivo were compared with the effects of methamphetamine(MAP) and reserpine(RES). These drugs were administered to rats in drinking water for two weeks. The contents of monoamines (DA and 5HT) and their major metabolites(DOPAC, HVA and 5HIAA) in eight discrete brain regions were measured by HPLC-ECD. After treatment with VP, DA levels decreased in the nucleus accumbens(N.ACC) and the suprachiasmatic nucleus(SCN), but no significant changes were demonstrated in the metabolites(DOPAC, HVA). 5HT levels decreased in the N.ACC, SCN and amygdara(AMY), and 5HIAA levels decreased in the raphe dorsalis(RD). GABA contents were increased in the N.ACC. After treatment with MAP, DA levels decreased in the N.ACC, striatum(STR) and ventro-medial hypothalamic regions(VMH). No significant change was shown in the metabolites. 5HT contents decreased in the N.ACC, STR, AMY, VMH and RD. 5HIAA contents decreased significantly in the RD. After treatment with RES, DA levels decreased in the N.ACC, STR and SCN. HVA contents decreased in the N.ACC and SCN, though they increased in the LH and SN. 5HT levels decreased in the N.ACC, SCN, AMY and RD. High 5HIAA concentrations were found in the N.ACC, STR, LH and VMH. DA, DOPAC and HVA levels were reduced more in several regions by co-administration of VP and MAP than by MAP treatment alone. DA was lowered more in the RD and HVA was lowered more in several regions by co-administration of VP and RES than by RES treatment alone. The well known locomotor hyperactivity induced by MAP was enhanced by VP. The present study suggests that there are at least two classes of voltage-gated calcium channels in the central nervous system related to the release of monioamines, one sensitive to VP and other not. In addition, chronic VP treatment may have an inhibitory effect on the release and synthesis of monoamines.
en-copyright=
kn-copyright=

en-aut-name=IkedaMasaaki
en-aut-sei=Ikeda
en-aut-mei=Masaaki
kn-aut-name=池田正明
kn-aut-sei=池田
kn-aut-mei=正明
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部脳代謝研究施設病態生化学部門
en-keyword=Verapamil
kn-keyword=Verapamil
en-keyword=Ca(2+)-channel
kn-keyword=Ca(2+)-channel
en-keyword=Methamphetamine
kn-keyword=Methamphetamine
en-keyword=Reserpine
kn-keyword=Reserpine
en-keyword=Monoamine release
kn-keyword=Monoamine release
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=1
article-no=
start-page=127
end-page=138
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19791201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Discharge Coeffi cient of a Sluice Gate Placed at Sudden Expansion of Open Channel
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In this paper the discharge coefficient of a sluice gate placed at the sudden expansion of an open channel is investigated theoretically and experimentally. Lateral and vertical expansions are treated in the study. The coefficients obtained for channels with sudden expansion
are compared with those for the straight channel. For free efflux, experimental results show that the coeffcients for expanded channels are always larger than those for a straiaht one,and that the coefficient for a channel to be fully expanded to both lateral and vertical directions takes about 1.2 times larger value than that for a straight one. For submerged efflux, the coefficient is obtained theoretically by using the efflux model shown in this study. The theoretical results explain the experimental ones fairly well. The coefficient for lateral expansion is always smaller than that for a straight channel. The minimum downstream water depth required to submerged efflux for the expanded channels becomes smaller than that for a straight channel.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=NagoHiroshi
kn-aut-sei=Nago
kn-aut-mei=Hiroshi
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=FurukawaSyuzo
kn-aut-sei=Furukawa
kn-aut-mei=Syuzo
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Depertment of Civil Engineering

affil-num=2
en-affil=
kn-affil=Depertment of Civil Engineering
END

start-ver=1.4
cd-journal=joma
no-vol=11
cd-vols=
no-issue=2
article-no=
start-page=27
end-page=36
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1977
dt-pub=19770125
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Contraction Coefficients of Underflow Gates with a Vertical Lip
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In this paper the influence of a vertical lip upon the contraction coefficients of underflow gates is discussed.
The coefficients of inclined gates with a vertical lip are investigated theoretically by using the method of conformal mapping. Solutions are obtained numerically for several values of the inclination of gate bottom. Theoretical solutions show that;as the length of a lip
increases, the coefficient rapidly decreases from the value
for the inclined gate, and when the length becomes of the
order of a gate openning,it takes a value to be nearly equal to that for a vertical gate. These theoretical results are verified by experiments.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=NagoHiroshi
kn-aut-sei=Nago
kn-aut-mei=Hiroshi
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Civil Engineering
END

start-ver=1.4
cd-journal=joma
no-vol=3
cd-vols=
no-issue=1
article-no=
start-page=127
end-page=130
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1968
dt-pub=19680901
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Contactless Vectormeter Using Thyristors
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In order to measure the iron loss of the silicon steel plates, we produced a vectormeter using a thyristor and a gate turn off thyristor by way of experiment. This equipment is very useful, because the frequency range is
improved very much in comparison with the vectormeter which is composed of the mechanical rectifying system using a synchronous motor, namely, is enlarged from 60Hz to 1kHz,
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=NakataTakayoshi
kn-aut-sei=Nakata
kn-aut-mei=Takayoshi
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=IshiharaYoshiyuki
kn-aut-sei=Ishihara
kn-aut-mei=Yoshiyuki
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Depertment of Electrical Engineering

affil-num=2
en-affil=
kn-affil=Depertment of Electrical Engineering
END

start-ver=1.4
cd-journal=joma
no-vol=2
cd-vols=
no-issue=1
article-no=
start-page=127
end-page=132
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1967
dt-pub=19670401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Method of Automatic Washing for Salt Contaminated Insulators
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Described in this paper is a method of automatic washing for salt contaminated insulators. An average value of leakage current through the surface of the pilot insulator in a duration is measured, for this is a function of the quantity of salt adhered and its moisture content. In each cycle, the program signals give one by one the instructions on a start and an end of the integration of leakage current, a detection of the integrated value, a stop of the washing device and a reset of the integrator. The integrator consists of RC circuit and the main detecting part consists of the thyristor whose firing gate voltage is used as a reference value. If the integrator output rises above the firing gate voltage, the pulse signals are made in the signal conversion part at the same time that the thyristor turns on, which are distributed to the pump motor or the electromagnetic valve. Then the insulators on hot-line are washed all together in the appointed duration. Finally, by the various experiments this method was proved to have enough accuracy and reliability in practical use. The conclusions are summarized as follows. (1) An average value of leakage current is justified to be the detecting variable. (2) The RC circuit used as the integrator is proved to be easy in maintenance. (3) Because of the fairly short duration of the detecting action, the integrator is kept in a sufficiently safe condition under expected environment.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=MisakiTakayoshi
kn-aut-sei=Misaki
kn-aut-mei=Takayoshi
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=KatoOsamu
kn-aut-sei=Kato
kn-aut-mei=Osamu
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=YamamotoHideki
kn-aut-sei=Yamamoto
kn-aut-mei=Hideki
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Electrical Engineering

affil-num=2
en-affil=
kn-affil=Department of Electrical Engineering

affil-num=3
en-affil=
kn-affil=Department of Electrical Engineering
END

start-ver=1.4
cd-journal=joma
no-vol=25
cd-vols=
no-issue=1
article-no=
start-page=37
end-page=50
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1990
dt-pub=19901214
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Second Harmonic Detection of Atmospheric Trace Gases with a Train-Pulse Driven Lead-Salt Tunable Diode Laser for an Operation at Peltier Cooling Temperature
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Is proposed a tunable diode laser absorption spectrometer system which employs a pulsed current to drive the diode laser still implementing a second-harmonic detection methods enhancing a signal to noise up to 104 times that the case without it. This system affords the lead-salt diode laser a higher operating temperature which allows a more compact deep cooling system. A principle is based on employing a gated integrator between the preamplifier and the lock-in amplifier. Investigations are made on the optimum selection of the gating aperture time interval as determined by response time of the infrared detector and the pulse width of the laser driving current.
en-copyright=
kn-copyright=

en-aut-name=BouzidiMoncef
en-aut-sei=Bouzidi
en-aut-mei=Moncef
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KogaRyuji
en-aut-sei=Koga
en-aut-mei=Ryuji
kn-aut-name=古賀隆治
kn-aut-sei=古賀
kn-aut-mei=隆治
aut-affil-num=2
ORCID=

en-aut-name=WadaOsami
en-aut-sei=Wada
en-aut-mei=Osami
kn-aut-name=和田修己
kn-aut-sei=和田
kn-aut-mei=修己
aut-affil-num=3
ORCID=

en-aut-name=KagawaNaoki
en-aut-sei=Kagawa
en-aut-mei=Naoki
kn-aut-name=香川直己
kn-aut-sei=香川
kn-aut-mei=直己
aut-affil-num=4
ORCID=

en-aut-name=HaiXu
en-aut-sei=Hai
en-aut-mei=Xu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KosakaMegumi
en-aut-sei=Kosaka
en-aut-mei=Megumi
kn-aut-name=小坂恵
kn-aut-sei=小坂
kn-aut-mei=恵
aut-affil-num=6
ORCID=

en-aut-name=SanoHiroya
en-aut-sei=Sano
en-aut-mei=Hiroya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=The Graduate School of Natural Science and Technology

affil-num=2
en-affil=
kn-affil=Department of Electrical and Electronic Engineering

affil-num=3
en-affil=
kn-affil=Department of Electrical and Electronic Engineering

affil-num=4
en-affil=
kn-affil=The Graduate School of Natural Science and Technology

affil-num=5
en-affil=
kn-affil=Measurement and Test Center, North-East Normal University

affil-num=6
en-affil=
kn-affil=Department of Electrical and Electronic Engineering

affil-num=7
en-affil=
kn-affil=Faculty of Engineering, Fukuyama University
END

start-ver=1.4
cd-journal=joma
no-vol=30
cd-vols=
no-issue=2
article-no=
start-page=21
end-page=25
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1996
dt-pub=19960329
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Analysis of Quantum Waveguide : Effective Width and Height of Potential for Quantum Wires under Split Gates
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In order to apply quantum waveguides to electronic devices, we calculate the electrostatic potential in the split-gate quantum wire and establish the relation between the electrostatic potential and the square well potential which is usually assumed in simulations of these waveguides. The height and width of the square well potential are expressed as simple functions of the gate voltage and their dependencies are clarified. The results may be useful in calculating the characteristics of
electronic devices based on quantum waveguides as functions of controllable parameters such as gate voltage.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=TachibanaHiroyuki
kn-aut-sei=Tachibana
kn-aut-mei=Hiroyuki
aut-affil-num=1
ORCID=

en-aut-name=TotsujiHiroo
en-aut-sei=Totsuji
en-aut-mei=Hiroo
kn-aut-name=東辻浩夫
kn-aut-sei=東辻
kn-aut-mei=浩夫
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Electric and Electronic Engneering

affil-num=2
en-affil=
kn-affil=Department of Electric and Electronic Engneering
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=11-12
article-no=
start-page=1177
end-page=1181
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=1991
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Evaluation of renal function by the ultrasonic Doppler technique
kn-title=超音波パルスドップラ法による腎機能評価に関する検討―Dynamic CT 及び Ccr との比較を中心として―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To evaluate the clinical application of the ultrasonic Doppler technique, renal arterial blood flow was measured in 7 normal subjects and 3 patients with renal dysfunction. For the purpose of correction of blood flow measured by the Doppler technique, some basic studies were performed. The ratio of peak diastolic to peak systolic velocity (D/S ratio) correlated well with both the creatinine clearance and the CA ratio calculated from the results of Dynamic CT. There was no correlation between the corrected velocity of the arterial blood flow and the creatinine clearance. The D/S ratio obtained by the ultrasonic Doppler technique is thought to be a useful parameter in the evaluation of the renal function. However, the Dynamic CT is thought to be superior in objectiveness to the ultrasonic Doppler technique.
en-copyright=
kn-copyright=

en-aut-name=SatohShuhei
en-aut-sei=Satoh
en-aut-mei=Shuhei
kn-aut-name=佐藤修平
kn-aut-sei=佐藤
kn-aut-mei=修平
aut-affil-num=1
ORCID=

en-aut-name=KitagawaTakahiro
en-aut-sei=Kitagawa
en-aut-mei=Takahiro
kn-aut-name=北川尚広
kn-aut-sei=北川
kn-aut-mei=尚広
aut-affil-num=2
ORCID=

en-aut-name=SatohNobuo
en-aut-sei=Satoh
en-aut-mei=Nobuo
kn-aut-name=佐藤伸夫
kn-aut-sei=佐藤
kn-aut-mei=伸夫
aut-affil-num=3
ORCID=

en-aut-name=TogamiIzumi
en-aut-sei=Togami
en-aut-mei=Izumi
kn-aut-name=戸上泉
kn-aut-sei=戸上
kn-aut-mei=泉
aut-affil-num=4
ORCID=

en-aut-name=KimotoShin
en-aut-sei=Kimoto
en-aut-mei=Shin
kn-aut-name=木本真
kn-aut-sei=木本
kn-aut-mei=真
aut-affil-num=5
ORCID=

en-aut-name=HirakiYoshio
en-aut-sei=Hiraki
en-aut-mei=Yoshio
kn-aut-name=平木祥夫
kn-aut-sei=平木
kn-aut-mei=祥夫
aut-affil-num=6
ORCID=

en-aut-name=UnoSatoru
en-aut-sei=Uno
en-aut-mei=Satoru
kn-aut-name=宇埜智
kn-aut-sei=宇埜
kn-aut-mei=智
aut-affil-num=7
ORCID=

en-aut-name=KumonHiromi
en-aut-sei=Kumon
en-aut-mei=Hiromi
kn-aut-name=公文裕巳
kn-aut-sei=公文
kn-aut-mei=裕巳
aut-affil-num=8
ORCID=

en-aut-name=OhmoriHiroyuki
en-aut-sei=Ohmori
en-aut-mei=Hiroyuki
kn-aut-name=大森弘之
kn-aut-sei=大森
kn-aut-mei=弘之
aut-affil-num=9
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部泌尿器科学教室

affil-num=8
en-affil=
kn-affil=岡山大学医学部泌尿器科学教室

affil-num=9
en-affil=
kn-affil=岡山大学医学部泌尿器科学教室
en-keyword=超音波パルスドップラ法
kn-keyword=超音波パルスドップラ法
en-keyword=D/S 比
kn-keyword=D/S 比
en-keyword=DCT
kn-keyword=DCT
en-keyword=CA ratio
kn-keyword=CA ratio
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=7-8
article-no=
start-page=993
end-page=1003
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=199108
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Ultrastructural study of left ventricular myocardium in aortic regurgitation : Correlations with preoperative cardiac functions at rest
kn-title=大動脈弁閉鎖不全症における左室心筋の組織構造変化と安静時心機能との関連に対する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We collected tissue samples from the left ventricular myocardium in 20 patients with aortic regurgitation, examined the correlation between myocardial ultrastructure and cardiac function at rest and obtained the following results. The extent of fibrosis in the myocardium and ultrastructural changes in the myocardial cells were respectively expressed in LM-Score and EM-Score. Furthermore, the myofibril changes expressed by the EM-Score were added to the LM-Score (Myo＋LM-Score), and each score was calculated and compared with the parameters of cardiac function. There was no significant correlation between EM-Score and parameters of cardiac function. LM-Score was correlated with Max dv/dt at r＝－0.471 (p<0.05) and with endodiastole (D/L) at r＝－0.567 (p<0.01) significantly, showing a negative linear correlation. Myo＋LM-Score was correlated with EF at r＝－0.574 (p<0.01) and with△ D at r＝－0.577 (p<0.01) significantly, showing a negative linear correlation. Among the cardiac functions at rest in patients with AR, the morphologic and diastolic parameters were closely related with the extent of fibrosis, and the contractility was closely related both with a change in myofibrils and with the extent of fibrosis. Thus, the cardiac functions at rest in patients with AR were correlated with the myocardial factors.
en-copyright=
kn-copyright=

en-aut-name=TsujiHisashi
en-aut-sei=Tsuji
en-aut-mei=Hisashi
kn-aut-name=辻尚志
kn-aut-sei=辻
kn-aut-mei=尚志
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二外科学教室
en-keyword=大動脈弁閉鎖不全症
kn-keyword=大動脈弁閉鎖不全症
en-keyword=安静時左心機能
kn-keyword=安静時左心機能
en-keyword=心筋組織構造変化
kn-keyword=心筋組織構造変化
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=9-10
article-no=
start-page=915
end-page=922
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=199210
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Development of double cancer in small cell lung cancer patients treated with intensive chemotherapy
kn-title=肺小細胞癌化学療法実施例における重複癌の発生に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Development of double cancer was evaluated in 337 small cell lung cancer patients who had received intensive chemotherapy with or without radiotherapy. Of them, 14 patients (4.2%) developed a second malignancy: non-small cell lung cancer in six, stomach cancer in four, acute myelogenous leukemia in two, liver cancer in one, and esophagus cancer in one. The relative risk for the development of double cancer calculated by person-year method utilizing age and sex adjusted cancer incidence in Japan was 2.75-fold (P<0.01). The risk of non-small cell lung cancer (8.75-fold) and acute myelogenous leukemia (37.82-fold) was particularly high. The cumulative risk for the development of double cancer was 2.0% at 1 year, 4.1% at 2 years, 14.3% at 3 years, and 100% at 8.1 years. Of 27 patients who survived disease-free for more than 2 years, 10 patients died; five patients (50%) died of double cancer, two died of infectious disease, and only three patients died from recurrent small cell lung cancer. These findings indicate that a cautious follow-up program for the detection of double cancer is indicated in patients with small cell lung cancer.
en-copyright=
kn-copyright=

en-aut-name=MiyakeKenichi
en-aut-sei=Miyake
en-aut-mei=Kenichi
kn-aut-name=三宅賢一
kn-aut-sei=三宅
kn-aut-mei=賢一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=肺小細胞癌
kn-keyword=肺小細胞癌
en-keyword=化学療法
kn-keyword=化学療法
en-keyword=重複癌
kn-keyword=重複癌
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=5-6
article-no=
start-page=513
end-page=526
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=1993
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Clinical investigation of ventricular direct interaction in valvular heart diseases before and after surgery by means of the equilibrium radionuclide ventriculography
kn-title=後天性弁膜疾患の手術前後における左室と右室の直接的相互作用に関する研究― RI 心プール法を用いて―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To elucidate direct ventricular interaction, equilibrium radionuclide ventriculography was performed on 18 cases of aortic regurgitation (AR) and 31 cases of mitral stenosis(MS) before and after open heart surgery. Patients with AR were divided into two groups by preoperative left ventricular volume : the normovolumic left ventricle (n-LV) group and the dilated left ventricle (d-LV) group. Patients with MS were divided into two groups by preoperative right ventricular volume : the normovolumic right ventricle (n-RV) group and the dilated rihgt ventricle (d-RV) group. In patients with AR, preoperative right ventricular systolic function in the d-LV group was significantly impaired compared with that in the n-LV group. Postoperative right ventricular systolic function in the d-LV group improved to show no significant difference compared to that in the n-LV group because surgery alleviated the left ventricular dilatation. In patients with MS, preoperative left ventricular systolic and diastolic functions in the d-RV group were significantly impaired compared with that of n-RV group. In d-RV group, postoperative left ventricular systolic and diastolic functions were significantly improved wheh right ventricular dilatation could be relieved postoperatively. In the present study, the existence of direct ventricular interaction influenced by the volume-overloaded ventricle was clarified.
en-copyright=
kn-copyright=

en-aut-name=ArakiKazuhiro
en-aut-sei=Araki
en-aut-mei=Kazuhiro
kn-aut-name=荒木一博
kn-aut-sei=荒木
kn-aut-mei=一博
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二外科学教室
en-keyword=後天性弁膜疾患
kn-keyword=後天性弁膜疾患
en-keyword=RI 心プール法
kn-keyword=RI 心プール法
en-keyword=左室機能
kn-keyword=左室機能
en-keyword=右室機能
kn-keyword=右室機能
en-keyword=心室間直接的相互作用
kn-keyword=心室間直接的相互作用
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=5-6
article-no=
start-page=499
end-page=512
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=1993
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Correlation between left ventricular diastolic function before and after valve replacement surgery and myocardial ultrastructural changes in patients with left ventricular volume-overloaded valvular heart diseases : Evaluation with gated blood pool scintigraphy using (99m)Tc
kn-title=左室容量負荷弁膜疾患の弁置換術前後における左室拡張能と心筋微細構造との関係―心プールシンチグラフｨーによる検討―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Left ventricular (LV) diastolic functions in 23 patients with aortic regurgitation (AR) and 22 patients with mitral regurgitation (MR) were evaluated by gated pool scintigraphy. LV myocardial biopsy was performed during open heart surgery, and LV myocardial ultrastructural chasges were evaluated by electron microscope. Correlation between LV diastolic function and myocardial ultrastructural change was examined. It was suggested that preoperative LV diastolic dysfunction occurred earlier than LV systolic dysfunction in patients with AR and MR. LV early diastolic dysfunction was especially significant in patients with AR. LV systolic function was significantly improved postoperatively compared with LV diastolic function in patients with AR and MR. It was suggested that LV interstitial fibrosis caused LV diastolic dysfunction in patients with AR and MR, and insufficiency of myocardial thickening as compensation in patients with MR. It was presumed that LV diastolic dysfunction was irreversilble in patients with AR and MR in the distant postoperative period due to persistence of the preoporative myocardial ultrastructural change, e.g, interstitial fibrosis. these LV diastolic indices measured by gated pool scintigraphy were useful in predicting LV ultrastructural changes and postoperative LV dysfunction in patients with LV volumeoverloaded valvular heart disease.
en-copyright=
kn-copyright=

en-aut-name=OkadaTomiro
en-aut-sei=Okada
en-aut-mei=Tomiro
kn-aut-name=岡田富朗
kn-aut-sei=岡田
kn-aut-mei=富朗
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二外科学教室
en-keyword=左室容量負荷弁膜疾患
kn-keyword=左室容量負荷弁膜疾患
en-keyword=左室拡張能
kn-keyword=左室拡張能
en-keyword=左室心筋微細構造
kn-keyword=左室心筋微細構造
en-keyword=心プールシンチグラフィー
kn-keyword=心プールシンチグラフィー
END

start-ver=1.4
cd-journal=joma
no-vol=106
cd-vols=
no-issue=1-2
article-no=
start-page=163
end-page=171
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1994
dt-pub=199402
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Quantitative analysis of cardiac function using cine MR
kn-title=シネ MRI の画像解析による心機能の定量評価に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Non-invasive techniques for measuring the dynamic behavior of the cardiac ventricle can be invaluable tool for diagnosing heart disease. In this paper, we present methods for quantia-tive analysis of cardiac function using magnetic rasonance images. A 256×256 magnetic resonance transaxial image of the cardiac ventricle was obtained from a healthy subject. After gray level thresholding and region segmentation, the bounday of the ventricular chamber was extracted. Then, the boundaries of the ventricular chamber were displayed therr-dimensionally using the Z-buffer algoritm. Thus, ventricular volume and ejection fraction were calcullated. In our example, left ventricular ejection fraction was 61%. These results agree with the corresponding data obtained by the echo-cardiography.
en-copyright=
kn-copyright=

en-aut-name=SeiTetsurou
en-aut-sei=Sei
en-aut-mei=Tetsurou
kn-aut-name=清哲朗
kn-aut-sei=清
kn-aut-mei=哲朗
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部放射線医学教室
en-keyword=MRI
kn-keyword=MRI
en-keyword=cardiac function
kn-keyword=cardiac function
en-keyword=image processing
kn-keyword=image processing
en-keyword=three dimensional raconstruction
kn-keyword=three dimensional raconstruction
END

start-ver=1.4
cd-journal=joma
no-vol=107
cd-vols=
no-issue=7-8
article-no=
start-page=91
end-page=98
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1995
dt-pub=19950831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Immobilization stress affected free radicals, superoxide dismutase activity and thiobarbituric acid reactive substances in the rat brain
kn-title=拘束スレレスのラット脳内フリーラジカル, スーパーオキシドジスムターゼ活性およびチオバルビツール酸反応物質への影響に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Immobilization stress for 6 hours induced hemorrhagic erosion in the rat stomach. Hydroxyl radicals singnificantly increased in the pons-medulla oblongata in stressed rats. Mitochondrial superoxide dismutase (SOD) activity was enhanced in the midbrain but was lowered in the cortex, hippocampus and cerebellum in stressed rats. Thiobarbituric acid reactive substances increased by stress in the cortex and midbrain. These finding suggested that immobilization stress generated hydroxyl radicals and accelerated lipid peroxidation, and affected mitocho-drial SOD activity which may lead to neuronal damage in stressed rats.
en-copyright=
kn-copyright=

en-aut-name=OkamuraYouko
en-aut-sei=Okamura
en-aut-mei=Youko
kn-aut-name=岡村容子
kn-aut-sei=岡村
kn-aut-mei=容子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部附属分子細胞医学研究施設神経情報学部門
en-keyword=拘束ストレス
kn-keyword=拘束ストレス
en-keyword=ヒドロキシルラジカル
kn-keyword=ヒドロキシルラジカル
en-keyword=スーパーオキシドジスムターゼ活性
kn-keyword=スーパーオキシドジスムターゼ活性
en-keyword=チオバルビツール酸反応物質
kn-keyword=チオバルビツール酸反応物質
en-keyword=脳
kn-keyword=脳
END

start-ver=1.4
cd-journal=joma
no-vol=5
cd-vols=
no-issue=1
article-no=
start-page=31
end-page=34
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2000
dt-pub=20000229
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Numerical Analysis of Unsteady Flow in Kojima Lake
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We study unsteady flow that models lake flow in Kojima Lake. We assume that a lake is connected to another area with gates, and that those gates are opened when the water level outside the gates is lower than the water level of the lake. We study unsteady flow due to the opening of the gates. We analyze the problem with the finite element method, and take detailed structures of the gates into account.
en-copyright=
kn-copyright=

en-aut-name=WatanabeMasaji
en-aut-sei=Watanabe
en-aut-mei=Masaji
kn-aut-name=渡辺雅二
kn-aut-sei=渡辺
kn-aut-mei=雅二
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
en-keyword=unsteady flow
kn-keyword=unsteady flow
en-keyword=lake flow
kn-keyword=lake flow
en-keyword=finite element method
kn-keyword=finite element method
END

start-ver=1.4
cd-journal=joma
no-vol=5
cd-vols=
no-issue=2
article-no=
start-page=169
end-page=181
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1998
dt-pub=1998
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Vertical Structure of Temperatures of Tree's Leaves and Gate Wall at Rashomon Doline
kn-title=羅生門ドリーネにおける樹木の葉温と壁面温度の鉛直構造について
en-subtitle=
kn-subtitle=
en-abstract=1996年夏季に羅生門の第一中間ドリーネ内の樹木の葉や壁面の温度の高度分布や経時変化の観測を行った。以下に得られた結果の主なものを列挙する。ドリーネ内の樹木の葉温は、水平方向に対しては、ほぼ一様な温度成層を示していた。樹木の葉温は、下層部で日変化巾が小さく、上層部で日変化巾が大きくなっていた。樹木の葉温は、高度が高くなるほど、高温を示す鉛直構造をもっていた。特に葉温の鉛直分布は、正午ごろに、高度差約9ｍの範囲で、温度差約12℃という非常に大きな正の鉛直勾配を示した。樹木の葉温が日最高温度を示す時間は、高度が高いほど早く、高度が下がるに従って遅くなっていた。羅生門の壁面温度は、樹木の葉温の鉛直構造と同じように、高度が高くなればなるほど、高温になっていた。また壁面の温度変動は、葉温の変動に比べて小さい。熱画像中に、周辺の温度と異なるホットスポットが見られた。これは、ドリーネ上部から流れ下りてきた暖かい水が地表面を濡らしている部分であり、ほぼ同じ場所の水のない部分の地表面温度と比べて約6℃も高くなっていた。高度方向に気温や地温に大きい温度勾配がある羅生門ドリーネにおいては、大雨などの場合に、上部から水が流れ下りてきた場合に、地表面温度を上げ、下層の気温を上昇させる可能性があることが指摘された。羅生門ドリーネにおいて、夏季に特異な葉温や壁面温度構造を形成しており、貴重な植物や動物が数多く生息できる温度環境にあることが、熱映像温度計を用いて確認できた。
kn-abstract=Temperatures of tree's leaves and gate wall were measured in the summer of 1996 at doline. Diurnal fluctuations of leaf temperatures were greater, the higher the position of leaf in the doline, and they showed maximum temperatures later, the deeper the leaf position. The leaf temperature of trees growing in the first collapse doline was uniform in the horizontal direction and had a stable thermal layer. The difference between leaf temperatures at a depth of 20 m and 11 m was about 12℃ around noon. The leaf temperature was always higher at the upper part than at the lower part of the doline throughout the day. Daily fluctuation of wall temperature was small,compared with that of leaf temperature. The vertical profile of wall temperature was similar to that of leaf temperature. The warm water flowing down from the upper part of the doline influenced the soil temperature in the lower part of the doline. The thermal imagery elucidated the peculiar vertical structure of leaf and wall temperature formed in the summer at Rashomon doline.
en-copyright=
kn-copyright=

en-aut-name=MiyashitaKoichi
en-aut-sei=Miyashita
en-aut-mei=Koichi
kn-aut-name=宮下晃一
kn-aut-sei=宮下
kn-aut-mei=晃一
aut-affil-num=1
ORCID=

en-aut-name=MaitaniToshihiko
en-aut-sei=Maitani
en-aut-mei=Toshihiko
kn-aut-name=米谷俊彦
kn-aut-sei=米谷
kn-aut-mei=俊彦
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学

affil-num=2
en-affil=
kn-affil=岡山大学
en-keyword=Rashomon
kn-keyword=Rashomon
en-keyword=Doline
kn-keyword=Doline
en-keyword=Leaf temperature
kn-keyword=Leaf temperature
en-keyword=Wall temperature
kn-keyword=Wall temperature
en-keyword=Thermal image
kn-keyword=Thermal image
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=19920328
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=随伴スペクトルと時間ゲーテｨングの大気メタン半導体レーザー分光分析への応用
kn-title=Adjoint Spectrum And Temporal Gating As Applied To The Diode Laster Spectrometry of Atmospheric Methane
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=BouzidiMoncef
kn-aut-sei=Bouzidi
kn-aut-mei=Moncef
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=39
cd-vols=
no-issue=1
article-no=
start-page=79
end-page=91
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1972
dt-pub=1972
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Discharge at Water-intake Structure
kn-title=取水施設の流入量に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This head work is the water-intake structure, by which irrigation water has been carried to the reservoir constructed in the other catchment basion. We always have intaken water from the river by this head work, even at the time of flood.  To design such structure, we have to know the rerationship between the gate opening and the discharge of water or the discharge coefficient which varies widely according to the river water level. That orifice formula could be used in calculation to obtain the amount of discharged water from the gate has experimentally been confirmed by Toch, Honma and others.  The discharge coefficient of the intake gate Cq is shown in its relationship to parameters expressing the gate geometry. Any agreement between actual gate discharge and Toch's experimental results could never be found when the gate geometry is different. Therefore, we can only obtain Cq value through a specific model study for a particular project. Specially in this intake mention should be made here to the fact that the loss of head Ф in the uniform flow sections upstreams and downstreams from the gate is ignored, and the value of Ф related to the Cq value.  Relation between Cq and Ф can be obtained by the following equation using the Bernoulli's energay theorem, in which ψ. Ф are head loss parameters,  Cq H1･H2 /√H12 (1+ψ) + H32 (Ф-l)  and Cq value can be obtained by calculating head loss. On the other hand, if the systematic graphical representation of the relationship between the value q and the elements is obtained by the experimental measurements of hydraulic model tests, q-H1/h～H3/h, in which H1,H3 are the depths of flow in the upstream and downstream from the gates, should be considered applicable to the practical work and useful in checking up the experimental values with theoretical solution.
en-copyright=
kn-copyright=

en-aut-name=WatanabeTadashi
en-aut-sei=Watanabe
en-aut-mei=Tadashi
kn-aut-name=渡辺忠
kn-aut-sei=渡辺
kn-aut-mei=忠
aut-affil-num=1
ORCID=

en-aut-name=OkadaJunji
en-aut-sei=Okada
en-aut-mei=Junji
kn-aut-name=岡田純治
kn-aut-sei=岡田
kn-aut-mei=純治
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学

affil-num=2
en-affil=
kn-affil=岡山大学
END