検索結果 217 件
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Takei, Kensuke| Inokuchi, Toshihiro| Hiraoka, Sakiko| Ishiguro, Mikako| Toyosawa, Junki| Aoyama, Yuki| Igawa, Shoko| Takeuchi, Keiko| Yamasaki, Yasushi| Kinugasa, Hideaki| Takahara, Masahiro| Kawano, Seiji| Mitsuhashi, Toshiharu| Otsuka, Motoyuki| |
| キーワード | CD, Crohn's disease LRG, Leucine-rich alpha-2 glycoprotein Fcal, Fecal calprotectin CRP, C-reactive protein ER, Endoscopic remission |
| 発行日 | 2025-05-13 |
| 出版物タイトル | BMC Gastroenterology |
| 巻 | 25巻 |
| 号 | 1号 |
| 出版者 | BMC |
| 開始ページ | 364 |
| ISSN | 1471-230X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2025. |
| 論文のバージョン | publisher |
| PubMed ID | 40355822 |
| DOI | 10.1186/s12876-025-03880-5 |
| Web of Science KeyUT | 001488265300002 |
| 関連URL | isVersionOf https://doi.org/10.1186/s12876-025-03880-5 |
| JaLCDOI | 10.18926/AMO/68726 |
|---|---|
| フルテキストURL | 79_3_185.pdf |
| 著者 | Yoshikawa, Ayumi| Taira, Naruto| Okanaga, Mayumi| Saito, Shinya| |
| 抄録 | We investigated the emotional changes that young patients with breast cancer need to undergo in order to foster relationship-building with their partners by conducting a qualitative descriptive study (March 1 to Nov. 26, 2021) and semi-structured interviews with eight postoperative patients (age 20-40 years) with breast cancer. The data were analyzed using the modified grounded theory approach (M-GTA), yielding five categories: (i) Awareness of being a breast cancer patient, (ii) Being at a loss, (iii) Support from significant others, (iv) The struggle to transition from being a patient with cancer to becoming “the person I want to be”, and (v) Reaching the “me” I want to be who can face building a relationship with a partner. These findings suggest that young breast cancer patients must feel that they can lead a normal life through activities such as work or acquiring qualifications before building relationships with their partners, and that getting closer to their desired selves is important. Nurses can provide information to young patients with breast cancer to assist them in building a solid relationship with their partners. We believe that this support may enhance the patients’ quality of life and help them achieve stronger relationships with their partners. |
| キーワード | breast cancer patient young patient single partners relationships |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-06 |
| 巻 | 79巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 185 |
| 終了ページ | 195 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| JaLCDOI | 10.18926/AMO/68722 |
|---|---|
| フルテキストURL | 79_3_147.pdf |
| 著者 | Watanabe, Haruki| Matsumoto, Yoshinori| Wada, Jun| |
| 抄録 | Pathogens or their components can induce long-lasting changes in the behavior of innate immune cells, a process analogous to “training” for future threats or environmental adaptation. However, such training can sometimes have unintended consequences, such as the development of autoimmunity. Systemic lupus erythematosus (SLE) is a chronic and heterogeneous autoimmune disease characterized by the production of autoantibodies and progressive organ damage. Innate immunity plays a central role in its pathogenesis, contributing through impaired clearance of apoptotic cells, excessive type I interferon production, and dysregulated formation of neutrophil extracellular traps. Recent studies have revealed that metabolites and nucleic acids derived from mitochondria, a crucial energy production site, directly regulate type I interferon and anti-inflammatory cytokine production. These insights have fueled interest in targeting metabolic pathways as a novel therapeutic approach for SLE, offering promise for improving long-term patient outcomes. |
| キーワード | systemic lupus erythematosus interferon tricarboxylic acid cycle innate immune memory trained immunity |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-06 |
| 巻 | 79巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 147 |
| 終了ページ | 155 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| JaLCDOI | 10.18926/AMO/68649 |
|---|---|
| フルテキストURL | 79_2_109.pdf |
| 著者 | Awai, Kyoko| Nakatsuka, Mikiya| |
| 抄録 | The status of postpartum depression was elucidated herein with the use of the Edinburgh Postnatal Depression Scale (EPDS) in women in Shikoku, Japan who became pregnant and gave birth after undergoing infertility treatment, including assisted reproductive technology (ART). The assessment was performed during their children’s 4-month health examination. The relationships between postpartum depression and the mothers’ background factors and scores on the Big Five personality traits scale were also examined. Of the Big Five personality traits, the scores for neuroticism were significantly higher in the ART group (n=71) than in the general infertility treatment (n=118) and natural pregnancy (n=872) groups. No significant differences in EPDS scores were seen among these three groups. A logistic regression analysis showed that neuroticism was associated with an EPDS score ≧9 points, (which is suggestive of postpartum depression, ) in all groups. Moreover, although a long-standing marriage had an inhibitory effect on postpartum depression in the natural pregnancy group, no such trend was seen in the ART group, which included many women with long-standing marriages. Particularly for women who become pregnant by ART, an individualized response that pays close attention to the woman’s personality traits is needed. |
| キーワード | infertility treatment assisted reproductive technology postpartum postpartum depression personality trait |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-04 |
| 巻 | 79巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 109 |
| 終了ページ | 116 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 40302282 |
| Web of Science KeyUT | 001485544200006 |
| JaLCDOI | 10.18926/AMO/68353 |
|---|---|
| フルテキストURL | 79_1_001.pdf |
| 著者 | Thiha, Moe| Hikita, Takao| Nakayama, Masanori| |
| 抄録 | Endothelial cell polarity is fundamental to the organization and function of blood vessels, influencing processes such as angiogenesis, vascular stability, and response to shear stress. This review elaborates on the molecular mechanisms that regulate endothelial cell polarity, focusing on key players like the PAR polarity complex and Rho family GTPases. These pathways coordinate the front–rear, apical–basal and planar polarity of endothelial cells, which are essential for the proper formation and maintenance of vascular structures. In health, endothelial polarity ensures not only the orderly development of blood vessels, with tip cells adopting distinct polarities during angiogenesis, but also ensures proper vascular integrity and function. In disease states, however, disruptions in polarity contribute to pathologies such as coronary artery disease, where altered planar polarity exacerbates atherosclerosis, and cancer, where disrupted polarity in tumor vasculature leads to abnormal vessel growth and function. Understanding cell polarity and its disruption is fundamental not only to comprehending how cells interact with their microenvironment and organize themselves into complex, organ-specific tissues but also to developing novel, targeted, and therapeutic strategies for a range of diseases, from cardiovascular disorders to malignancies, ultimately improving patient outcomes. |
| キーワード | blood vessel endothelial cell cell polarity atherosclerosis cancer |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-02 |
| 巻 | 79巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 1 |
| 終了ページ | 7 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 40012154 |
| Web of Science KeyUT | 001440463800001 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Matsumoto, Naomi| Mitsui, Takashi| Tamai, Kei| Hirota, Tomoya| Masuyama, Hisashi| Yorifuji, Takashi| |
| キーワード | Cesarean delivery Delivery methods Long-term outcome Child development Outcome-wide approach |
| 発行日 | 2025-01-20 |
| 出版物タイトル | Scientific Reports |
| 巻 | 15巻 |
| 号 | 1号 |
| 出版者 | Nature Portfolio |
| 開始ページ | 2485 |
| ISSN | 2045-2322 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2025 |
| 論文のバージョン | publisher |
| PubMed ID | 39833288 |
| DOI | 10.1038/s41598-025-87043-2 |
| Web of Science KeyUT | 001402008500024 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41598-025-87043-2 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Morita, Satoru| Otsuka, Yuki| Masuda, Yohei| Soejima, Yoshiaki| Otsuka, Fumio| |
| キーワード | calcium pyrophosphate crystal deposition disease crowned dens syndrome dental treatment fever neck pain |
| 発行日 | 2025-02-02 |
| 出版物タイトル | Clinical Case Reports |
| 巻 | 13巻 |
| 号 | 2号 |
| 出版者 | Wiley |
| 開始ページ | e70168 |
| ISSN | 2050-0904 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2025 The Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 39902195 |
| DOI | 10.1002/ccr3.70168 |
| Web of Science KeyUT | 001410822700001 |
| 関連URL | isVersionOf https://doi.org/10.1002/ccr3.70168 |
| JaLCDOI | 10.18926/AMO/67666 |
|---|---|
| フルテキストURL | 78_5_413.pdf |
| 著者 | Kashihara, Kenichi| Irisawa, Minoru| Takao, Wataru| |
| 抄録 | We investigated patients with migraine or migraine variants who exhibited focal cerebral hypoperfusion on arterial spin-labeled (ASL) magnetic resonance (MR) imaging along with neurological symptoms. Fourteen patients with migraine demonstrated focal cerebral hypoperfusion. Three other patients did not have a history of recurrent headaches but exhibited comparable cerebral hypoperfusion to migraine patients on ASL-MRI in addition to neurological symptoms. Patients with migraine may present with neurological symptoms associated with cortical spreading depression during, after, or even without a headache phase. Additionally, the isolated neurological symptoms may be caused by a pathophysiology identical to that of migraine but without presenting with recurrent headaches. |
| キーワード | arterial spin-labeled magnetic resonance imaging cortical spreading depression migraine complex migraine without headache vertigo |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-10 |
| 巻 | 78巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 413 |
| 終了ページ | 421 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 39467660 |
| JaLCDOI | 10.18926/AMO/67655 |
|---|---|
| フルテキストURL | 78_5_357.pdf |
| 著者 | Yamawaki, Ryoko| Oda, Yoshiaki| Yamane, Shuhei| Uotani, Koji| Misawa, Haruo| Katayama, Yoshimi| Hamada, Masanori| Ozaki, Toshifumi| |
| 抄録 | Research on postural control in patients with adolescent idiopathic scoliosis (AIS) has focused on static postural control, with few studies assessing dynamic postural control. We aimed to identify factors affecting index of postural stability (IPS), a dynamic postural control parameter, in patients with AIS. The participants comprised 50 female patients with AIS. We measured the IPS using stabilometry to evaluate dynamic postural control ability. We investigated age of the participants, major curve position (thoracic or thoracolumbar/lumbar), Cobb angle, and coronal balance. We then assessed the relationships between stabilometry parameters and other variables. IPS was analyzed with a linear regression model. Coronal balance, major curve position, and age each correlated with dynamic postural control ability. The Cobb angle showed no correlation with any of the parameters. Our results offer new insights into the assessment of postural control in patients with AIS. |
| キーワード | adolescent idiopathic scoliosis postural control coronal balance index of postural stability stabilometry |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-10 |
| 巻 | 78巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 357 |
| 終了ページ | 362 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 39467653 |
| Web of Science KeyUT | 001343346400001 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Miyamoto, Taisei| Tsuruta, Takeshi| Teraoka, Mao| Wang, Tianyang| Nishino, Naoki| |
| キーワード | cyclic oligosaccharides gut bacteria immunoglobulin A |
| 発行日 | 2024-08-23 |
| 出版物タイトル | Nutrients |
| 巻 | 16巻 |
| 号 | 17号 |
| 出版者 | MDPI |
| 開始ページ | 2824 |
| ISSN | 2072-6643 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 39275142 |
| DOI | 10.3390/nu16172824 |
| Web of Science KeyUT | 001310989100001 |
| 関連URL | isVersionOf https://doi.org/10.3390/nu16172824 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Yamakata, Akira| Kato, Kosaku| Urakami, Takumi| Tsujimura, Sota| Murayama, Kasumi| Higashi, Masahiro| Sato, Hirofumi| Kobori, Yasuhiro| Umeyama, Tomokazu| Imahori, Hiroshi| |
| 発行日 | 2024-07-10 |
| 出版物タイトル | Chemical Science |
| 巻 | 15巻 |
| 号 | 32号 |
| 出版者 | Royal Society of Chemistry |
| 開始ページ | 12686 |
| 終了ページ | 12694 |
| ISSN | 2041-6520 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 The Author(s). |
| 論文のバージョン | publisher |
| DOI | 10.1039/d4sc00917g |
| Web of Science KeyUT | 001272504400001 |
| 関連URL | isVersionOf https://doi.org/10.1039/d4sc00917g |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Yamamoto, Toshio| Kashihara, Kazunari| Furuta, Tomoyuki| Zhang, Qian| Yu, En| Ma, Jian Feng| |
| 発行日 | 2024-07-02 |
| 出版物タイトル | Scientific Reports |
| 巻 | 14巻 |
| 号 | 1号 |
| 出版者 | Nature Portfolio |
| 開始ページ | 15139 |
| ISSN | 2045-2322 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2024 |
| 論文のバージョン | publisher |
| PubMed ID | 38956423 |
| DOI | 10.1038/s41598-024-66036-7 |
| Web of Science KeyUT | 001262145700066 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41598-024-66036-7 |
| JaLCDOI | 10.18926/AMO/66915 |
|---|---|
| フルテキストURL | 78_2_123.pdf |
| 著者 | Saeki, Kyosuke| Fujiwara, Hideaki| Seike, Keisuke| Kuroi, Taiga| Nishimori, Hisakazu| Tanaka, Takehiro| Matsuoka, Ken-ichi| Fujii, Nobuharu| Maeda, Yoshinobu| |
| 抄録 | Chronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity following allogeneic hematopoietic cell transplantation (HCT), but its pathogenesis remains unclear. Recently, haplo-identical HCT with post-transplant cyclophosphamide (Haplo-HCT with PTCY) was found to achieve a low incidence rate of acute GVHD and chronic GVHD. However, while the pathogenesis of acute GVHD following Haplo-HCT with PTCY has been well investigated, that of chronic GVHD remains to be elucidated, especially in HLA-matched HCT with PTCY. Based on its safety profile, PTCY is currently applied for the human leucocyte antigen (HLA)-matched HCT setting. Here, we investigated the mechanisms of chronic GVHD following HLA-matched HCT with PTCY using a well-defined mouse chronic GVHD model. PTCY attenuated clinical and pathological chronic GVHD by suppressing effector T-cells and preserving regulatory T-cells compared with a control group. Additionally, we demonstrated that cyclosporine A (CsA) did not show any additional positive effects on attenuation of GVHD in PTCY-treated recipients. These results suggest that monotherapy with PTCY without CsA could be a promising strategy for the prevention of chronic GVHD following HLA-matched HCT. |
| キーワード | GVHD posttransplant cyclophosphamide hematopoietic cell transplantation HLA-identical |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-04 |
| 巻 | 78巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 123 |
| 終了ページ | 134 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38688830 |
| Web of Science KeyUT | 001229151800004 |
| JaLCDOI | 10.18926/AMO/66664 |
|---|---|
| フルテキストURL | 78_1_001.pdf |
| 著者 | Sun, Cuiming| Matsukawa, Akihiro| |
| 抄録 | Liver fibrosis, which ultimately leads to liver cirrhosis and hepatocellular carcinoma, is a major health burden worldwide. The progression of liver fibrosis is the result of the wound-healing response of liver to repeated injury. Hepatic macrophages are cells with high heterogeneity and plasticity and include tissue-resident macrophages termed Kupffer cells, and recruited macrophages derived from circulating monocytes, spleen and peritoneal cavity. Studies have shown that hepatic macrophages play roles in the initiation and progression of liver fibrosis by releasing inflammatory cytokines/chemokines and pro-fibrogenic factors. Furthermore, the development of liver fibrosis has been shown to be reversible. Hepatic macrophages have been shown to alternately regulate both the regression and turnover of liver fibrosis by changing their phenotypes during the dynamic progression of liver fibrosis. In this review, we summarize the role of hepatic macrophages in the progression and regression of liver fibrosis. |
| キーワード | ERK-MAPK SPRED2 fibrosis macrophages |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-02 |
| 巻 | 78巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 1 |
| 終了ページ | 8 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38419308 |
| Web of Science KeyUT | 001203658200006 |
| JaLCDOI | 10.18926/AMO/66156 |
|---|---|
| フルテキストURL | 77_6_635.pdf |
| 著者 | Ikeda, Tomohiro| Okamura, Kazunori| Hasegawa, Masaki| Tanaka, Satoshi| Kanai, Shusaku| |
| 抄録 | In the management of post-injury patients with activity limitations, methods to prevent musculoskeletal disorders and hasten recovery are important. This randomized controlled, single-blinded study was a preliminary investigation of the combined effect of nutritional support with neuromuscular electrical stimulation (NMES) on muscle strength and thickness. Healthy young adult males (median age, 21 years) were enrolled; each of their hands was randomly assigned to one of the following four groups: Placebo, Nutrition, NMES, and Nutrition + NMES. All participants received whey protein or placebo (3x/week for 6 weeks) and NMES training (3x/week for 6 weeks) on the abductor digiti minimi (ADM) muscle of either the left or right hand. ADM muscle strength and thickness were analyzed at baseline and at week 7. We analyzed 38 hands (9 Placebo, 10 Nutrition, 9 NMES, 10 Nutrition + NMES). There was significantly greater muscle strengthening in the Nutrition + NMES group compared to the Placebo group or the NMES group, but no significant difference in gain of muscle thickness. The combined intervention may be effective in improving muscle strength. Future clinical trials targeting various muscles after sports-related injuries are warranted. |
| キーワード | whey protein electrical stimulation muscle strength healthy volunteers |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-12 |
| 巻 | 77巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 635 |
| 終了ページ | 645 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38145938 |
| Web of Science KeyUT | 001164631200009 |
| JaLCDOI | 10.18926/AMO/66154 |
|---|---|
| フルテキストURL | 77_6_619.pdf |
| 著者 | Oe, Kenichi| Iida, Hirokazu| Sogawa, Shohei| Kobayashi, Fumito| Nakamura, Tomohisa| Saito, Takanori| |
| 抄録 | This study retrospectively evaluated 41 consecutive open reductions and internal fixations following primary or revision total hip arthroplasty, which required trochanteric claw plate fixation for greater trochanteric fracture or osteotomy between January 2008 and December 2020. The mean duration of clinical follow-up was 4.2 years (range, 1-13 years). The patients included 13 men and 28 women, with a mean age of 68 years (range, 32-87 years). The indications for intervention included trochanteric osteotomy, intraoperative fracture, and non-union including postoperative fracture in 6, 9, and 26 cases, respectively. The mean Merle d’Aubigné Clinical Score improved from 9.4 points (range, 5-15 points) pre-operatively, to 14.3 points (range, 9-18 points) at the last follow-up. Bone union occurred in 35 cases (85%), while implant breakage occurred in four cases. At the last follow-up, the mean Merle d’Aubigné Clinical Scores of bone union and non-union were 15.3 and 14.1, respectively (p=0.48). The Kaplan-Meier survival rate, with the endpoint being revision surgery for pain, non-union, dislocation, or implant breakage, at 10 years was 80.0% (95% confidence interval: 62.6-97.4%). Greater trochanteric fixation using a trochanteric claw plate yielded successful results. |
| キーワード | greater trochanteric fracture trochanteric osteotomy claw plate total hip arthroplasty |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-12 |
| 巻 | 77巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 619 |
| 終了ページ | 625 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38145936 |
| Web of Science KeyUT | 001164631200007 |
| JaLCDOI | 10.18926/AMO/66151 |
|---|---|
| フルテキストURL | 77_6_595.pdf |
| 著者 | Bando, Takashi| Chuma, Masayuki| Hamano, Hirofumi| Niimura, Takahiro| Okada, Naoto| Kondo, Masateru| Izumi, Yuki| Ishida, Shunsuke| Yoshioka, Toshihiko| Asada, Mizuho| Zamami, Yoshito| Takechi, Kenshi| Goda, Mitsuhiro| Miyata, Koji| Yagi, Kenta| Izawa-Ishizawa, Yuki| Azuma, Momoyo| Yanagawa, Hiroaki| Tasaki, Yoshikazu| Ishizawa, Keisuke| |
| 抄録 | There is a growing concern about the relationship between vancomycin-associated nephrotoxicity (VAN) and concomitant use of nephrotoxins. We examined this relationship by combined retrospective analyses of two real-world databases. Initially, the FDA Adverse Event Reporting System (FAERS) was analyzed for the effects of concomitant use of one or more nephrotoxins on VAN and the types of combinations of nephrotoxins that exacerbate VAN. Next, electronic medical records (EMRs) of patients who received vancomycin (VCM) at Tokushima University Hospital between January 2006 and March 2019 were examined to confirm the FAERS analysis. An elevated reporting odds ratio (ROR) was observed with increases in the number of nephrotoxins administered (VCM + one nephrotoxin, adjusted ROR (95% confidence interval [CI]) 1.67 [1.51-1.85]; VCM + ≥2 nephrotoxins, adjusted ROR [95% CI] 1.54 [1.37-1.73]) in FAERS. EMRs analysis showed that the number of nephrotoxins was associated with higher incidences of VAN [odds ratio: 1.99; 95% CI: 1.42-2.78]. Overall, concomitant use of nephrotoxins was associated with an increased incidence of VAN, especially when at least one of those nephrotoxins was a renal hypoperfusion medication (furosemide, non-steroidal anti-inflammatory drugs, and vasopressors). The concomitant use of multiple nephrotoxins, especially including renal hypoperfusion medication, should be avoided to prevent VAN. |
| キーワード | vancomycin-associated nephrotoxicity polypharmacy nephrotoxin spontaneous adverse event reporting database electronic medical records |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-12 |
| 巻 | 77巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 595 |
| 終了ページ | 605 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38145933 |
| Web of Science KeyUT | 001164631200004 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Ikura, Ryohei| Kajimoto, Kota| Park, Junsu| Murayama, Shunsuke| Fujiwara, Yusei| Osaki, Motofumi| Suzuki, Tomohiro| Shirakawa, Hidenori| Kitamura, Yujiro| Takahashi, Hiroaki| Ohashi, Yasumasa| Obata, Seiji| Harada, Akira| Ikemoto, Yuka| Nishina, Yuta| Uetsuji, Yasutomo| Matsuba, Go| Takashima, Yoshinori| |
| キーワード | stress-strain sensor carbon composite movable cross-link supramolecular materials polymericmaterials tough materials upcycling |
| 発行日 | 2023-09-11 |
| 出版物タイトル | ACS Polymers Au |
| 巻 | 3巻 |
| 号 | 5号 |
| 出版者 | American Chemical Society |
| 開始ページ | 394 |
| 終了ページ | 405 |
| ISSN | 2694-2453 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 The Authors. |
| 論文のバージョン | publisher |
| DOI | 10.1021/acspolymersau.3c00010 |
| Web of Science KeyUT | 001066001800001 |
| 関連URL | isVersionOf https://doi.org/10.1021/acspolymersau.3c00010 |
| JaLCDOI | 10.18926/AMO/65757 |
|---|---|
| フルテキストURL | 77_4_439.pdf |
| 著者 | Shiwaku, Takahiro| Ishida, Hisashi| Tatebe, Yasuhisa| Tamefusa, Kosuke| Ochi, Motoharu| Fujiwara, Kaori| Kubo, Toshihide| Nakata, Eiji| Washio, Kana| Tsukahara, Hirokazu| |
| 抄録 | A three-year-old boy with Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia (Ph+ALL) presented with an osteolytic lesion in his right upper arm. Tyrosine kinase inhibitors (TKIs) such as imatinib and dasatinib are an essential component throughout the course of treatment for Ph+ALL. However, TKIs are reported to affect the bone metabolism. In the treatment course of the current patient, the osteolytic lesion quickly improved despite the continuous use of TKIs, even during the concomitant use of corticosteroids. This suggests that TKIs can be safely given with concomitant corticosteroids to children with Ph+ALL, even when osteolytic lesions are present. |
| キーワード | acute lymphoblastic leukemia children tyrosine kinase inhibitor osteolysis |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-08 |
| 巻 | 77巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 439 |
| 終了ページ | 442 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 37635146 |
| Web of Science KeyUT | 001088434900002 |
| JaLCDOI | 10.18926/AMO/65741 |
|---|---|
| フルテキストURL | 77_4_359.pdf |
| 著者 | Koshida, Tomohiro| Maruta, Toyoaki| Tanaka, Nobuhiko| Hidaka, Kotaro| Kurogi, Mio| Nemoto, Takayuki| Yanagita, Toshihiko| Takeya, Ryu| Tsuneyoshi, Isao| |
| 抄録 | Pulsed radiofrequency (PRF) is a safe method of treating neuropathic pain by generating intermittent electric fields at the needle tip. Resiniferatoxin (RTX) is an ultrapotent agonist of transient receptor potential vanilloid subtype-1 (TRPV1) receptors. We investigated the mechanism of PRF using a rat model of RTX-induced neuropathic pain. After administering RTX intraperitoneally, PRF was applied to the right sciatic nerve. We observed the changes in TRPV1, calcitonin gene-related peptide (CGRP), and brain-derived neurotrophic factor (BDNF) in the dorsal root ganglia by western blotting. Expressions of TRPV1 and CGRP were significantly lower in the contralateral (RTX-treated, PRF-untreated) tissue than in control rats (p<0.0001 and p<0.0001, respectively) and the ipsilateral tissues (p<0.0001 and p<0.0001, respectively). BDNF levels were significantly higher in the contralateral tissues than in the control rats (p<0.0001) and the ipsilateral tissues (p<0.0001). These results suggest that, while TRPV1 and CGRP are decreased by RTX-induced neuronal damage, increased BDNF levels result in pain development. PRF may promote recovery from neuronal damage with concomitant restoration of TRPV1 and CGRP, and exert its analgesic effect by reversing BDNF increase. Further research is required to understand the role of TRPV1 and CGRP restoration in improving mechanical allodynia. |
| キーワード | pulsed radiofrequency resiniferatoxin transient receptor potential vanilloid subtype-1 (TRPV1) calcitonin gene-related peptide (CGRP) brain-derived neurotrophic factor (BDNF) |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-08 |
| 巻 | 77巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 359 |
| 終了ページ | 364 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 37635135 |
| Web of Science KeyUT | 001163659800011 |