検索結果 - 岡山大学学術成果リポジトリ

Prognostic value of the liver fibrosis marker fibrosis-5 index in patients with severe isolated tricuspid regurgitation: comparison with fibrosis-4 index

フルテキストURL	fulltext.pdf
著者	Nakashima, Mitsutaka\| Miyoshi, Toru\| Tanakaya, Machiko\| Saito, Takaaki\| Katayama, Yusuke\| Sakuragi, Satoru\| Takaya, Yoichi\| Ito, Hiroshi\|
キーワード	Liver disorder Fibrosis-4 index Fibrosis-5 index Isolated tricuspid regurgitation Major adverse cardiac events
備考	The version of record of this article, first published in Heart and Vessels, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00380-023-02268-3\|
発行日	2023-04-23
出版物タイトル	Heart and Vessels
巻	38巻
号	9号
出版者	Springer Science and Business Media LLC
開始ページ	1181
終了ページ	1189
ISSN	0910-8327
NCID	AA10452161
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2023
論文のバージョン	publisher
PubMed ID	37087702
DOI	10.1007/s00380-023-02268-3
Web of Science KeyUT	000974679600001
関連URL	isVersionOf https://doi.org/10.1007/s00380-023-02268-3

Outcomes of solitary postoperative recurrence of esophageal squamous cell carcinoma diagnosed with FDG-PET/CT and treated with definitive radiation therapy

フルテキストURL	fulltext.pdf
著者	Ihara, Hiroki\| Yoshio, Kotaro\| Tanabe, Shunsuke\| Sugiyama, Soichi\| Hashimoto, Masashi\| Maeda, Naoaki\| Akagi, Shinsuke\| Takao, Soshi\| Noma, Kazuhiro\| Hiraki, Takao\|
キーワード	Radiation therapy Esophageal squamous cell carcinoma Recurrence 18F-fluorodeoxyglucose positron emission tomography Survival
備考	The version of record of this article, first published in Esophagus, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10388-023-01000-4\|
発行日	2023-04-07
出版物タイトル	Esophagus
巻	20巻
号	3号
出版者	Springer Science and Business Media LLC
開始ページ	548
終了ページ	556
ISSN	1612-9059
NCID	AA11885266
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2023
論文のバージョン	publisher
PubMed ID	37027045
DOI	10.1007/s10388-023-01000-4
Web of Science KeyUT	000964113700001
関連URL	isVersionOf https://doi.org/10.1007/s10388-023-01000-4

A Case of Gallbladder Cancer with Trousseau Syndrome Successfully Treated Using Radical Resection

JaLCDOI	10.18926/AMO/66931
フルテキストURL	78_2_201.pdf
著者	Masunaga, Akari\| Tabuchi, Motoyasu\| Sakamoto, Shinya\| Yoshimatsu, Rika\| Matsumoto, Manabu\| Iwata, Jun\| Okabayashi, Takehiro\|
抄録	Trousseau syndrome is characterized by cancer-associated systemic thrombosis. We describe the first case of a successfully treated gallbladder adenocarcinoma accompanied by Trousseau syndrome. A 66-year-old woman presented with right hemiplegia. Magnetic resonance imaging identified multiple cerebral infarctions. Her serum carbohydrate antigen 19-9 and D-dimer levels were markedly elevated, and a gallbladder tumor was detected via abdominal computed tomography. Venous ultrasonography of the lower limbs revealed a deep venous thrombus in the right peroneal vein. These findings suggested that the brain infarctions were likely caused by Trousseau syndrome associated with her gallbladder cancer. Radical resection of the gallbladder tumor was performed. The resected gallbladder was filled with mucus and was pathologically diagnosed as an adenocarcinoma. Her postoperative course was uneventful, and she received a one-year course of adjuvant therapy with oral S-1. No cancer recurrence or thrombosis was noted 26 months postoperatively. Despite concurrent Trousseau syndrome, a radical cure of the primary tumor and thrombosis could be achieved with the appropriate treatment.
キーワード	gallbladder cancer Trousseau syndrome radical surgery
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2024-04
巻	78巻
号	2号
出版者	Okayama University Medical School
開始ページ	201
終了ページ	204
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38688839
Web of Science KeyUT	001227932200001

The Impact of Light Touch and Pin Prick on Functional Outcomes in Patients with Traumatic Spinal Cord Injury

JaLCDOI	10.18926/AMO/66925
フルテキストURL	78_2_163.pdf
著者	Deguchi, Takayuki\| Kanda, Kanae\| Furusawa, Kazunari\| Nlandu Roger Ngatu\| Hirao, Tomohiro\|
抄録	A spinal cord injury (SCI) can cause severe lifelong functional disability and profoundly affect an individual’s daily life. We investigated the prediction of patients’ post-SCI functional outcomes by evaluating sensory scores rather than motor scores, as the latter’s association with functional outcomes is well established. We examined patients’ responses to a light touch (LT) and pin prick (PP) at admission and the response data’s usefulness as predictors of functional outcomes (i.e., ability to perform activities of daily living) at discharge. This exploratory observational study used data from the Japanese National Spinal Cord Injury Database (SCI-J). Data from 3,676 patients who met the inclusion criteria and were admitted for an SCI between 1997 and 2020 were analyzed. The motor score of the Functional Independence Measure (mFIM) at discharge was used as an index of functional outcome. A multiple regression analysis revealed that the mFIM was associated with both the LT response (β=0.07 (0.01), p<0.001) and the PP response (β=0.07 (0.01), p<0.001) at admission. The false discovery rate log-worth values for LT and PP were 6.6 and 8.5, respectively. Our findings demonstrate that LT and PP scores at admission can help predict patients’ functional outcomes after an SCI, although the magnitude of their contributions is not high.
キーワード	functional independence measure light touch pin prick spinal cord injury Japanese National Spinal Cord Injury Database
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2024-04
巻	78巻
号	2号
出版者	Okayama University Medical School
開始ページ	163
終了ページ	170
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38688834
Web of Science KeyUT	001229151800008

GenIce-core: Efficient algorithm for generation of hydrogen-disordered ice structures

フルテキストURL	fulltext.pdf
著者	Matsumoto, Masakazu\| Yagasaki, Takuma\| Tanaka, Hideki\|
備考	This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Masakazu Matsumoto, Takuma Yagasaki, Hideki Tanaka; GenIce-core: Efficient algorithm for generation of hydrogen-disordered ice structures. J. Chem. Phys. 7 March 2024; 160 (9): 094101. https://doi.org/10.1063/5.0198056 and may be found at https://doi.org/10.1063/5.0198056.\| This fulltext file will be available in Mar. 2025.\|
発行日	2024-03-01
出版物タイトル	The Journal of Chemical Physics
巻	160巻
号	9号
出版者	AIP Publishing
開始ページ	094101
ISSN	0021-9606
NCID	AA00694991
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 Author(s).
論文のバージョン	publisher
PubMed ID	38426513
DOI	10.1063/5.0198056
Web of Science KeyUT	001178860800001
関連URL	isVersionOf https://doi.org/10.1063/5.0198056

Japan-epiretinal membrane (J-ERM) registry: A prospective cohort study protocol investigating the surgical outcome of epiretinal membrane

フルテキストURL	fulltext.pdf
著者	Kanzaki, Yuki\| Matoba, Ryo\| Ishihara, Kenji\| Morita, Tetsuro\| Muraoka, Yuki\| Kimura, Shuhei\| Koto, Takashi\| Kawasaki, Ryo\| Baba, Takayuki\| Okamoto, Fumiki\| Inoue, Makoto\| Sakamoto, Taiji\| Tsujikawa, Akitaka\| Morizane, Yuki\|
発行日	2024-02-08
出版物タイトル	PLoS ONE
巻	19巻
号	2号
出版者	Public Library of Science
開始ページ	e0297347
ISSN	1932-6203
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 Kanzaki et al.
論文のバージョン	publisher
PubMed ID	38329968
DOI	10.1371/journal.pone.0297347
Web of Science KeyUT	001164302700019
関連URL	isVersionOf https://doi.org/10.1371/journal.pone.0297347

Oxygen-evolving photosystem II structures during S1–S2–S3 transitions

フルテキストURL	fulltext.pdf
著者	Li, Hongjie\| Nakajima, Yoshiki\| Nango, Eriko\| Owada, Shigeki\| Yamada, Daichi\| Hashimoto, Kana\| Luo, Fangjia\| Tanaka, Rie\| Akita, Fusamichi\| Kato, Koji\| Kang, Jungmin\| Saitoh, Yasunori\| Kishi, Shunpei\| Yu, Huaxin\| Matsubara, Naoki\| Fujii, Hajime\| Sugahara, Michihiro\| Suzuki, Mamoru\| Masuda, Tetsuya\| Kimura, Tetsunari\| Thao, Tran Nguyen\| Yonekura, Shinichiro\| Yu, Long-Jiang\| Tosha, Takehiko\| Tono, Kensuke\| Joti, Yasumasa\| Hatsui, Takaki\| Yabashi, Makina\| Kubo, Minoru\| Iwata, So\| Isobe, Hiroshi\| Yamaguchi, Kizashi\| Suga, Michihiro\| Shen, Jian-Ren\|
備考	The version of record of this article, first published in Nature, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41586-023-06987-5\|
発行日	2024-01-31
出版物タイトル	Nature
巻	626巻
号	7999号
出版者	Springer Science and Business Media LLC
開始ページ	670
終了ページ	677
ISSN	0028-0836
NCID	AA00752384
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2024
論文のバージョン	publisher
PubMed ID	38297122
DOI	10.1038/s41586-023-06987-5
Web of Science KeyUT	001179152900004
関連URL	isVersionOf https://doi.org/10.1038/s41586-023-06987-5

Association between oral condition and subjective psychological well-being among older adults attending a university hospital dental clinic: A cross-sectional study

フルテキストURL	fulltext.pdf
著者	Takeuchi, Noriko\| Sawada, Nanami\| Ekuni, Daisuke\| Morita, Manabu\|
発行日	2023-11-28
出版物タイトル	PLoS ONE
巻	18巻
号	11号
出版者	Public Library of Science
開始ページ	e0295078
ISSN	1932-6203
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 Takeuchi et al.
論文のバージョン	publisher
PubMed ID	38015962
DOI	10.1371/journal.pone.0295078
Web of Science KeyUT	001124505200026
関連URL	isVersionOf https://doi.org/10.1371/journal.pone.0295078

Inhibitory Effect of a Tankyrase Inhibitor on Mechanical Stress-Induced Protease Expression in Human Articular Chondrocytes

フルテキストURL	fulltext.pdf
著者	Hotta, Yoshifumi\| Nishida, Keiichiro\| Yoshida, Aki\| Nasu, Yoshihisa\| Nakahara, Ryuichi\| Naniwa, Shuichi\| Shimizu, Noriyuki\| Ichikawa, Chinatsu\| Lin, Deting\| Fujiwara, Tomohiro\| Ozaki, Toshifumi\|
キーワード	osteoarthritis chondrocyte mechanical stress tankyrases XAV939 SOX9 ADAMTS-5 MMP-13 IL-1β NF-κB β-catenin
発行日	2024-01-24
出版物タイトル	International Journal of Molecular Sciences
巻	25巻
号	3号
出版者	MDPI
開始ページ	1443
ISSN	1661-6596
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 by the authors.
論文のバージョン	publisher
PubMed ID	38338721
DOI	10.3390/ijms25031443
Web of Science KeyUT	001161430700001
関連URL	isVersionOf https://doi.org/10.3390/ijms25031443

Long-Term Follow-up Data of a Multi-Institutional Phase-2 Study of S-1/oxaliplatin and Bevacizumab Therapy in Patients with Advanced Colorectal Cancer: The HiSCO-02 Study

JaLCDOI	10.18926/AMO/66670
フルテキストURL	78_1_047.pdf
著者	Shimomura, Manabu\| Shinozaki, Katsunori\| Yano, Takuya\| Akabane, Shintaro\| Ohdan, Hideki\| Hiroshima Surgical study group of Clinical Oncology (HiSCO)\|
抄録	Oral fluoropyrimidines (FUs) have certain advantages over intravenous FUs, such as longer intervals between outpatient visits, no requirement for central venous port (CVP) implantation, and lower incidence of neutropenia. We previously reported the efficacy of S-1/oxaliplatin (SOX) with bevacizumab therapy as a first-line treatment for advanced colorectal cancer (CRC) in a prospective phase-II multi-institutional clinical trial (HiSCO-02 study). However, our prognostic data at the time lacked a sufficient observation period. Herein, we analyze the longer-term follow-up data, focusing on the status of eventual CVP implantation via an open-label, non-randomized, multicenter study. This study enrolled 55 patients (mean age, 64 years), of whom 43 died (41 of primary cancer). The median overall survival was 22.7 months (95% CI: 20.1-34.7 months). Post-treatment regimens after failure of first-line treatment were initiated in 43 patients; CPT11-based regimens were selected in most cases, and other oral FU combinations in nine. CVP was implanted in 35 patients prior to first-line treatment; eleven of the remaining 20 patients did not require CVP implantation. In conclusion, we report here the final prognostic update of the Phase II clinical trial examining the efficacy of SOX plus bevacizumab therapy, the results of which confirm the clinical efficacy of this regimen.
キーワード	metastatic colorectal cancer chemotherapy S-1 prospective phase II study
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2024-02
巻	78巻
号	1号
出版者	Okayama University Medical School
開始ページ	47
終了ページ	52
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38419314
Web of Science KeyUT	001203658200005

Regression of Necrotic Lesions after Methotrexate Withdrawal in Patients with Methotrexate-Associated Lymphoproliferative Disorders: A Retrospective CT Study

JaLCDOI	10.18926/AMO/66668
フルテキストURL	78_1_029.pdf
著者	Kitayama, Takahiro\| Tanaka, Takashi\| Kanie, Yuichiro\| Marukawa, Yohei\| Kojima, Katsuhide\| Tanaka, Takehiro\| Takao, Soshi\| Hiraki, Takao\|
抄録	This retrospective study investigated whether necrotic lesions detected on a computed tomography (CT) scan are more regressive than non-necrotic lesions after methotrexate withdrawal in patients pathologically diagnosed with methotrexate-associated lymphoproliferative disorders (MTX-LPD). In total, 89 lesions extracted from 24 patients on CT scans were included in the analysis. All patients had been evaluated for the presence of necrosis within lesions via CT scan upon first suspicion of MTX-LPD (baseline CT scan). The percentage lesion size reduction between the baseline and initial follow-up CT scan was calculated. The association between necrosis within lesions and size changes was estimated via linear regression analyses using both crude and adjusted models. Necrosis was significantly more common in extranodal lesions (27 out of 30 lesions, 90%) than in nodal lesions (9 out of 59 lesions, 15%, p<0.001). In the crude model, the regression of necrotic lesions was 58.5% greater than that of non-necrotic lesions; the difference was statistically significant (p<0.001). Additionally, the longest diameter of necrotic lesions at the baseline CT scan was significantly greater than that of non-necrotic lesions (p<0.001). Based on the adjusted model, necrotic lesions showed 49.3% greater regression than non-necrotic lesions (p=0.017). Necrosis detected on a CT scan was found to be an independent predictor of regression after MTX withdrawal in patients with MTX-LPD.
キーワード	methotrexate lymphoproliferative disorder computed tomography necrosis
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2024-02
巻	78巻
号	1号
出版者	Okayama University Medical School
開始ページ	29
終了ページ	36
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2024 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38419312
Web of Science KeyUT	001203658200001

Hydrogen in Transplantation: Potential Applications and Therapeutic Implications

フルテキストURL	fulltext.pdf
著者	Obara, Takafumi\| Naito, Hiromichi\| Nojima, Tsuyoshi\| Hirayama, Takahiro\| Hongo, Takashi\| Ageta, Kohei\| Aokage, Toshiyuki\| Hisamura, Masaki\| Yumoto, Tetsuya\| Nakao, Atsunori\|
キーワード	hydrogen organ transplantation ischemia reperfusion
発行日	2024-01-06
出版物タイトル	Biomedicines
巻	12巻
号	1号
出版者	MDPI
開始ページ	118
ISSN	2227-9059
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 by the authors.
論文のバージョン	publisher
PubMed ID	38255223
DOI	10.3390/biomedicines12010118
Web of Science KeyUT	001149475800001
関連URL	isVersionOf https://doi.org/10.3390/biomedicines12010118

公表学術論文等リスト　2023

タイトル（別表記）	The List of Published by Members of the Faculty From January to December 2023.
フルテキストURL	srfa_113_061_073.pdf
出版物タイトル	岡山大学農学部学術報告
発行日	2024-02-01
巻	113巻
開始ページ	61
終了ページ	73
ISSN	2186-7755
言語	日本語
論文のバージョン	publisher

Clinical Features of Patients With Second Primary Lung Cancer After Head and Neck Cancer

フルテキストURL	fulltext20240123-02.pdf
著者	Takatsu, Fumiaki\| Suzawa, Ken\| Okazaki, Mikio\| Shien, Kazuhiko\| Yamamoto, Hiromasa\| Watanabe, Mototsugu\| Hayama, Makio\| Ueno, Tsuyoshi\| Sugimoto, Ryujiro\| Maki, Yuho\| Fujiwara, Toshiya\| Okita, Riki\| Inokawa, Hidetoshi\| Tao, Hiroyuki\| Hirami, Yuji\| Matsuda, Eisuke\| Kataoka, Kazuhiko\| Yamashita, Motohiro\| Sano, Yoshifumi\| Matsuura, Motoki\| Mizutani, Hisao\| Toyooka, Shinichi\|
備考	© 2024 by The Society of Thoracic Surgeons. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/\| This fulltext file will be available in Dec. 2024.\|
発行日	2024-01
出版物タイトル	The Annals of Thoracic Surgery
巻	117巻
号	1号
出版者	Elsevier BV
開始ページ	181
終了ページ	188
ISSN	0003-4975
NCID	AA00533201
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2024 by The Society of Thoracic Surgeons
論文のバージョン	author
PubMed ID	35595090
DOI	10.1016/j.athoracsur.2022.04.052
Web of Science KeyUT	001137577900001
関連URL	isVersionOf https://doi.org/10.1016/j.athoracsur.2022.04.052

Clinical significance of gastrointestinal bleeding history in patients who undergo left atrial appendage closure

フルテキストURL	fulltext.pdf
著者	Kikuchi, Tatsuya\| Kono, Yoshiyasu\| Nakagawa, Koji\| Okada, Hiroyuki\| Miyamoto, Masakazu\| Takaya, Yoichi\| Hirata, Shoichiro\| Inoo, Shoko\| Kuraoka, Sakiko\| Okanoue, Shotaro\| Matsueda, Katsunori\| Satomi, Takuya\| Hamada, Kenta\| Iwamuro, Masaya\| Kawano, Seiji\| Kawahara, Yoshiro\|
キーワード	antithrombotic drugs gastrointestinal bleeding left atrial appendage closure
発行日	2023-12-27
出版物タイトル	JGH Open
巻	8巻
号	1号
出版者	Wiley
開始ページ	e13009
ISSN	2397-9070
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 The Authors.
論文のバージョン	publisher
DOI	10.1002/jgh3.13009
Web of Science KeyUT	001131741800001
関連URL	isVersionOf https://doi.org/10.1002/jgh3.13009

Epiretinal Membrane Impairs the Inner Retinal Layer in a Traction Force-Dependent Manner

フルテキストURL	fulltext.pdf
著者	Kanzaki, Yuki\| Matoba, Ryo\| Kimura, Shuhei\| Hosokawa, Mio M.\| Shiode, Yusuke\| Doi, Shinichiro\| Morita, Tetsuro\| Kanzaki, Sayumi\| Takasu, Ippei\| Tanikawa, Atsuhiro\| Morizane, Yuki\|
キーワード	Epiretinal membrane En face OCT Retinal traction force Inner nuclear layer Focal macular electroretinogram
発行日	2023-09
出版物タイトル	Ophthalmology Science
巻	3巻
号	3号
出版者	Elsevier
開始ページ	100312
ISSN	2666-9145
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 by the American Academy of Ophthalmology.
論文のバージョン	publisher
PubMed ID	37214764
DOI	10.1016/j.xops.2023.100312
Web of Science KeyUT	000998320200001
関連URL	isVersionOf https://doi.org/10.1016/j.xops.2023.100312

Effects of liquefied sake lees on growth performance and faecal and blood characteristics in Japanese Black calves

フルテキストURL	fulltext.pdf
著者	Katsumata, S.\| Hayashi, Y.\| Oishi, K.\| Tsukahara, T.\| Inoue, R.\| Obata, A.\| Hirooka, H.\| Kumagai, H.\|
キーワード	By-products Faecal microbiota Japanese Black cattle Preweaning calves Saccharomyces cerevisiae
発行日	2023-07
出版物タイトル	animal
巻	17巻
号	7号
出版者	Elsevier
開始ページ	100873
ISSN	1751-7311
NCID	AA12181724
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 The Authors.
論文のバージョン	publisher
PubMed ID	37399705
DOI	10.1016/j.animal.2023.100873
Web of Science KeyUT	001029012700001
関連URL	isVersionOf https://doi.org/10.1016/j.animal.2023.100873

Random Mutational Analysis Targeting Residue K155 within the Transmembrane β-Hairpin of the Mosquitocidal Mpp46Ab Toxin

フルテキストURL	fulltext.pdf
著者	Miyazaki, Midoka\| Asakura, Mami\| Ide, Toru\| Hayakawa, Tohru\|
キーワード	mosquito-larvicidal toxin Bacillus thuringiensis TK-E6 Culex pipiens mosquito larvae site-directed mutagenesis electrophysiologic analysis
発行日	2023-12-01
出版物タイトル	Biology
巻	12巻
号	12号
出版者	MDPI
開始ページ	1481
ISSN	2079-7737
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 by the authors.
論文のバージョン	publisher
PubMed ID	38132307
DOI	10.3390/biology12121481
Web of Science KeyUT	001132518500001
関連URL	isVersionOf https://doi.org/10.3390/biology12121481

Concomitant Use of Multiple Nephrotoxins including Renal Hypoperfusion Medications Causes Vancomycin-Associated Nephrotoxicity: Combined Retrospective Analyses of Two Real-World Databases

JaLCDOI	10.18926/AMO/66151
フルテキストURL	77_6_595.pdf
著者	Bando, Takashi\| Chuma, Masayuki\| Hamano, Hirofumi\| Niimura, Takahiro\| Okada, Naoto\| Kondo, Masateru\| Izumi, Yuki\| Ishida, Shunsuke\| Yoshioka, Toshihiko\| Asada, Mizuho\| Zamami, Yoshito\| Takechi, Kenshi\| Goda, Mitsuhiro\| Miyata, Koji\| Yagi, Kenta\| Izawa-Ishizawa, Yuki\| Azuma, Momoyo\| Yanagawa, Hiroaki\| Tasaki, Yoshikazu\| Ishizawa, Keisuke\|
抄録	There is a growing concern about the relationship between vancomycin-associated nephrotoxicity (VAN) and concomitant use of nephrotoxins. We examined this relationship by combined retrospective analyses of two real-world databases. Initially, the FDA Adverse Event Reporting System (FAERS) was analyzed for the effects of concomitant use of one or more nephrotoxins on VAN and the types of combinations of nephrotoxins that exacerbate VAN. Next, electronic medical records (EMRs) of patients who received vancomycin (VCM) at Tokushima University Hospital between January 2006 and March 2019 were examined to confirm the FAERS analysis. An elevated reporting odds ratio (ROR) was observed with increases in the number of nephrotoxins administered (VCM + one nephrotoxin, adjusted ROR (95% confidence interval [CI]) 1.67 [1.51-1.85]; VCM + ≥2 nephrotoxins, adjusted ROR [95% CI] 1.54 [1.37-1.73]) in FAERS. EMRs analysis showed that the number of nephrotoxins was associated with higher incidences of VAN [odds ratio: 1.99; 95% CI: 1.42-2.78]. Overall, concomitant use of nephrotoxins was associated with an increased incidence of VAN, especially when at least one of those nephrotoxins was a renal hypoperfusion medication (furosemide, non-steroidal anti-inflammatory drugs, and vasopressors). The concomitant use of multiple nephrotoxins, especially including renal hypoperfusion medication, should be avoided to prevent VAN.
キーワード	vancomycin-associated nephrotoxicity polypharmacy nephrotoxin spontaneous adverse event reporting database electronic medical records
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-12
巻	77巻
号	6号
出版者	Okayama University Medical School
開始ページ	595
終了ページ	605
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	38145933
Web of Science KeyUT	001164631200004

SHRSP5/Dmcr rats fed a high-fat and high-cholesterol diet develop disease-induced sarcopenia as nonalcoholic steatohepatitis progresses

フルテキストURL	K0006949_abstract_review.pdf K0006949_fulltext.pdf K0006949_summary.pdf
著者	山元修成\|
発行日	2023-09-25
資料タイプ	学位論文
学位授与番号	甲第6949号
学位授与年月日	2023-09-25
学位・専攻分野	博士（保健学）
授与大学	岡山大学
言語	英語
著作権者	© 2023 Elsevier GmbH.