検索結果 620 件
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Sumii, Yuichi| Kondo, Takumi| Ikegawa, Shuntaro| Fukumi, Takuya| Iwamoto, Miki| Nishimura, Midori Filiz| Sugiura, Hiroyuki| Sando, Yasuhisa| Nakamura, Makoto| Meguri, Yusuke| Matsushita, Takashi| Tanimine, Naoki| Kimura, Maiko| Asada, Noboru| Ennishi, Daisuke| Maeda, Yoshinobu| Matsuoka, Ken-Ichi| |
| 発行日 | 2023-04-24 |
| 出版物タイトル | JCI Insight |
| 巻 | 8巻 |
| 号 | 8号 |
| 出版者 | American Society for Clinical Investigation |
| 開始ページ | e162180 |
| ISSN | 2379-3708 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023, Sumii et al. |
| 論文のバージョン | publisher |
| PubMed ID | 37092551 |
| DOI | 10.1172/jci.insight.162180 |
| Web of Science KeyUT | 000978256300001 |
| 関連URL | isVersionOf https://doi.org/10.1172/jci.insight.162180 |
| タイトル（別表記） | Current status and problems regarding HCC screening for the NAFLD patients |
|---|---|
| 著者 | 大塚 基之| |
| キーワード | 脂肪肝 NASH 肝癌 スクリーニング |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2023-04-01 |
| 巻 | 135巻 |
| 号 | 1号 |
| 開始ページ | 18 |
| 終了ページ | 21 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.135.18 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2023 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.135.18 |
| タイトル（別表記） | The 2021 Incentive Award of the Okayama Medical Association in Cancer Research (2021 Hayashibara Prize and Yamada Prize) |
|---|---|
| 著者 | 山崎 泰史| |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2023-04-01 |
| 巻 | 135巻 |
| 号 | 1号 |
| 開始ページ | 9 |
| 終了ページ | 11 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.135.9 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2023 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.135.9 |
| タイトル（別表記） | The 28th Annual Meeting of the Japanese Society for Hereditary Tumors |
|---|---|
| 著者 | 藤原 俊義| 田中屋 宏爾| 重安 邦俊| |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2022-12-01 |
| 巻 | 134巻 |
| 号 | 3号 |
| 開始ページ | 192 |
| 終了ページ | 194 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.134.192 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2022 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.134.192 |
| タイトル（別表記） | Primary biliary cholangitis : PBC |
|---|---|
| 著者 | 高木 章乃夫| 竹内 康人| 安中 哲也| |
| キーワード | 原発性胆汁性胆管炎 原発性胆汁性肝硬変 ウルソデオキシコール酸 ベザフィブラート |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2022-12-01 |
| 巻 | 134巻 |
| 号 | 3号 |
| 開始ページ | 180 |
| 終了ページ | 184 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.134.180 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2022 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.134.180 |
| タイトル（別表記） | A case of duodenal diverticulitis in a patient receiving tocilizumab for rheumatoid arthritis |
|---|---|
| 著者 | 岩室 雅也| 馬場 雄己| 河原 祥朗| 岡田 裕之| |
| 抄録 | A Japanese woman was diagnosed with rheumatoid arthritis at the age of 41. At the age of 56, her rheumatoid arthritis worsened and a subcutaneous injection of tocilizumab and oral prednisolone was administered, which led to an improvement of arthritis. At the age of 57, right lower abdominal pain and vomiting suddenly appeared. Abdominal computed tomography showed a parapapillary diverticulum in the descending duodenum. The diverticulum was filled with residue, and an inflammation of the surrounding adipose tissue was observed; no free air was found. The patient was diagnosed with duodenal diverticulitis and treated with antibiotics, which resulted in an uneventful recovery. The maximum value of CRP was 1.88㎎/dL on the third day of hospitalization. Esophagogastroduodenoscopy performed on the 8th day of hospitalization revealed a parapapillary diverticulum with adhesion of pus and redness of the mucosa at the opening of the diverticulum, consistent with diverticulitis. This case highlights that diverticulitis in infrequent areas such as the duodenum may occur in patients who are treated with tocilizumab. In addition, inflammation of diverticulitis may be underestimated because abnormal laboratory values such as those induced by inflammatory reactions are less likely to occur during tocilizumab treatment. |
| キーワード | トシリズマブ（tocilizumab） 十二指腸憩室（duodenal diverticulum） 憩室炎（diverticulitis） |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2022-12-01 |
| 巻 | 134巻 |
| 号 | 3号 |
| 開始ページ | 166 |
| 終了ページ | 170 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.134.166 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2022 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.134.166 |
| タイトル（別表記） | The 2021 Incentive Award of the Okayama Medical Association in Cancer Research (2021 Hayashibara Prize and Yamada Prize) |
|---|---|
| 著者 | 垣内 慶彦| |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2022-12-01 |
| 巻 | 134巻 |
| 号 | 3号 |
| 開始ページ | 142 |
| 終了ページ | 144 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.134.142 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2022 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.134.142 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Takagi, Kosei| Noma, Kazuhiro| Nagai, Yasuo| Kikuchi, Satoru| Umeda, Yuzo| Yoshida, Ryuichi| Fuji, Tomokazu| Yasui, Kazuya| Tanaka, Takehiro| Kashima, Hajime| Yagi, Takahito| Fujiwara, Toshiyoshi| |
| キーワード | ampullary carcinoma carcinomas of the papilla of Vater cancer-associated fibroblast outcome survival recurrence |
| 発行日 | 2023-03-16 |
| 出版物タイトル | Frontiers in Oncology |
| 巻 | 13巻 |
| 出版者 | Frontiers Media |
| 開始ページ | 1072106 |
| ISSN | 2234-943X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 Takagi, Noma, Nagai, Kikuchi, Umeda, Yoshida, Fuji, Yasui, Tanaka, Kashima, Yagi and Fujiwara. |
| 論文のバージョン | publisher |
| PubMed ID | 37007101 |
| DOI | 10.3389/fonc.2023.1072106 |
| Web of Science KeyUT | 000961528000001 |
| 関連URL | isVersionOf https://doi.org/10.3389/fonc.2023.1072106 |
| JaLCDOI | 10.18926/AMO/65152 |
|---|---|
| フルテキストURL | 77_2_209.pdf |
| 著者 | Sakamoto, Masaki| Teraishi, Fuminori| Shigeyasu Kunitoshi| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| 抄録 | A 70-year-old male with anal pain and fever was diagnosed with rectal cancer perforation and abscess in the right gluteus maximus (GM) muscle. He underwent a transverse colon colostomy followed by preoperative capecitabine+oxaliplatin. Some local control was achieved but a residual abscess was observed in the right GM muscle. To secure circumferential resection margin by tumor reduction, he received chemoradiotherapy as total neoadjuvant therapy (TNT) and underwent laparoscopic abdominoperineal resection, D3 lymph node dissection, combined coccyx resection, and partial resection of the right GM muscle. The skin defect and pelvic dead space were filled with a right lateral vastus lateral great muscle flap. Histopathologically, the resected specimen showed no tumor cells in the primary tumor or lymph nodes, indicating a pathological complete response (pCR). This case suggests that TNT might improve the R0 resection and pCR rates and overall survival. |
| キーワード | locally advanced rectal cancer total neoadjuvant therapy lateral vastus lateral great muscle flap |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-04 |
| 巻 | 77巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 209 |
| 終了ページ | 213 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 37094960 |
| Web of Science KeyUT | 000982563800003 |
| JaLCDOI | 10.18926/AMO/65149 |
|---|---|
| フルテキストURL | 77_2_193.pdf |
| 著者 | Ikeda, Tomohiro| Noma, Kazuhiro| Okura, Kazuki| Katayama, Sho| Takahashi, Yusuke| Maeda, Naoaki| Tanabe, Shunsuke| Wakita, Akiyuki| Hamada, Masanori| Fujiwara, Toshiyoshi| Senda, Masuo| |
| 抄録 | This retrospective study aimed to investigate the validity of a 30-sec chair stand test (CS-30) as a simple test to assess exercise tolerance and clinical outcomes in 53 Japanese patients with esophageal cancer. There was a strong correlation between the results of CS-30 and the 6-min walk test (6MWT), the gold standard for assessing exercise tolerance (r=0.759). Furthermore, fewer patients whose CS-30 score was greater than 16 (the cutoff value defined based on 6MWT) experienced pneumonia in their postoperative course. These results suggest that exercise tolerance could be assessed using CS-30, and its cutoff value may be useful in predicting postoperative pneumonia risk. |
| キーワード | esophageal cancer exercise tolerance rehabilitation |
| Amo Type | Short Communication |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-04 |
| 巻 | 77巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 193 |
| 終了ページ | 197 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 37094957 |
| Web of Science KeyUT | 000982503800009 |
| JaLCDOI | 10.18926/AMO/65146 |
|---|---|
| フルテキストURL | 77_2_169.pdf |
| 著者 | Inoue, Kanae| Fujita, Rio| Nagahara, Takatoshi| Murakami, Shiho| Nagai, Yuta| Moriwake, Rina| Miyake, Nozomi| Wakuta, Akiko| Kariyama, Kazuya| Nishimura, Mamoru| Nouso, Kazuhiro| |
| 抄録 | Alcoholic liver disease is a risk factor for non-virus-related hepatocellular carcinoma (HCC), which is increasing in prevalence. This study aimed to identify the factors for recovery from alcoholic liver failure. Sixty-two consecutive patients hospitalized for alcoholic liver failure at Okayama City Hospital were enrolled. The characteristics of patients who survived to the 1-month follow-up and whose liver function improved to Child–Pugh A at 3 months (CPA3) and 12 months (CPA12) were compared with the rest of the patients. The survivors at 1 month (50 patients) were significantly younger than the deceased patients and had better liver and renal function with higher levels of γ-glutamyl transferase (GGT). The same factors, except renal function, were correlated with achieving CPA3. High AST, ALT, and GGT levels as well as short spleen length, total abstinence, and good Child–Pugh scores at admission were identified as factors for achieving CPA12. The extent of alcohol intake before admission was not identified as a risk factor in any analysis. In conclusion, baseline liver function is crucial for survival and achieving CPA3, whereas high transaminase and γ-GTP levels, the absence of splenomegaly, and total abstinence are significant factors for achieving CPA12. |
| キーワード | alcoholic liver failure risk factors recovery |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-04 |
| 巻 | 77巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 169 |
| 終了ページ | 177 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 37094954 |
| Web of Science KeyUT | 000982503800006 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Takagi, Kosei| Umeda, Yuzo| Yoshida, Ryuichi| Fuji, Tomokazu| Yasui, Kazuya| Kimura, Jiro| Hata, Nanako| Yagi, Takahito| Fujiwara, Toshiyoshi| |
| キーワード | robotic surgery minimally invasive surgery hepato-pancreato-biliary surgery Pfannenstiel incision |
| 発行日 | 2023-03-02 |
| 出版物タイトル | Journal of Clinical Medicine |
| 巻 | 12巻 |
| 号 | 5号 |
| 出版者 | MDPI |
| 開始ページ | 1971 |
| ISSN | 2077-0383 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 36902758 |
| DOI | 10.3390/jcm12051971 |
| Web of Science KeyUT | 000947498100001 |
| 関連URL | isVersionOf https://doi.org/10.3390/jcm12051971 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Kikuchi, Tatsuya| Tanaka, Yoshinori| Ichimura, Kouichi| Okada, Hiroyuki| Okamoto, Ryoichi| |
| キーワード | Hodgkin lymphoma Hemophagocytic syndrome TAFRO syndrome |
| 発行日 | 2023-02-21 |
| 出版物タイトル | Journal of Medical Case Reports |
| 巻 | 17巻 |
| 号 | 1号 |
| 出版者 | BMC |
| 開始ページ | 61 |
| ISSN | 1752-1947 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2023. |
| 論文のバージョン | publisher |
| PubMed ID | 36805700 |
| DOI | 10.1186/s13256-023-03776-6 |
| Web of Science KeyUT | 000934595500003 |
| 関連URL | isVersionOf https://doi.org/10.1186/s13256-023-03776-6 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Kawano, Seiji| Oka, Shiro| Shiotani, Akiko| Hashimoto, Shinichi| Takahashi, Sakuma| Handa, Osamu| Takami, Taro| Inaba, Tomoki| Okada, Hiroyuki| Tanaka, Shinji| |
| キーワード | capsule endoscopy Crohn's disease upper small intestine young patients |
| 発行日 | 2022-12-16 |
| 出版物タイトル | Medicine |
| 巻 | 101巻 |
| 号 | 50号 |
| 出版者 | Lippincott, Williams & Wilkins |
| 開始ページ | e32424 |
| ISSN | 0025-7974 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 the Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 36550892 |
| DOI | 10.1097/MD.0000000000032424 |
| Web of Science KeyUT | 000921335500100 |
| 関連URL | isVersionOf https://doi.org/10.1097/MD.0000000000032424 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Tanaka, Hiroyoshi Y.| Nakazawa, Takuya| Enomoto, Atsushi| Masamune, Atsushi| Kano, Mitsunobu R.| |
| キーワード | pancreatic cancer tumor microenvironment nanomedicine fibrosis extracellular matrix fibroblast |
| 発行日 | 2023-01-24 |
| 出版物タイトル | Cancers |
| 巻 | 15巻 |
| 号 | 3号 |
| 出版者 | MDPI |
| 開始ページ | 724 |
| ISSN | 2072-6694 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 36765684 |
| DOI | 10.3390/cancers15030724 |
| Web of Science KeyUT | 000929314700001 |
| 関連URL | isVersionOf https://doi.org/10.3390/cancers15030724 |
| フルテキストURL | fulltext20230228-1.pdf |
|---|---|
| 著者 | Ishino, Takamasa| Kawashima, Shusuke| Tanji, Etsuko| Ueno, Toshihide| Ueda, Youki| Ogasawara, Sadahisa| Sato, Kazuhito| Mano, Hiroyuki| Ishihara, Soichiro| Kato, Naoya| Kawazu, Masahito| Togashi, Yosuke| |
| 発行日 | 2023-02-02 |
| 出版物タイトル | British Journal of Cancer |
| 出版者 | Springer Science and Business Media LLC |
| ISSN | 0007-0920 |
| NCID | AA00574355 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2023 |
| 論文のバージョン | publisher |
| PubMed ID | 36732592 |
| DOI | 10.1038/s41416-023-02165-6 |
| Web of Science KeyUT | 000925746000001 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Iwamuro, Masaya| Takahashi, Takahide| Hirabata, Araki| Tanaka, Takehiro| Otsuka, Fumio| Okada, Horoyuki| |
| キーワード | carcinogenesis lymphocytes helicobacter pylori gastric adenocarcinoma flow cytometry |
| 発行日 | 2022-11-20 |
| 出版物タイトル | Cureus Journal Of Medical Science |
| 巻 | 14巻 |
| 号 | 11号 |
| 出版者 | Cureus Inc. |
| 開始ページ | e31713 |
| ISSN | 2168-8184 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 Iwamuro et al. |
| 論文のバージョン | publisher |
| PubMed ID | 36569708 |
| DOI | 10.7759/cureus.31713 |
| Web of Science KeyUT | 000918257500029 |
| 関連URL | isVersionOf https://doi.org/10.7759/cureus.31713 |
| JaLCDOI | 10.18926/AMO/64368 |
|---|---|
| フルテキストURL | 77_1_91.pdf |
| 著者 | Takahashi, Toshiaki| Kakiuchi, Yoshihiko| Kikuch, Satoru| Kuroda, Shinji| Takeda, Sho| Shigeyasu, Kunitoshi| Kondo, Yoshitaka| Teraishi, Fuminori| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| 抄録 | An annular pancreas is a rare anomaly of the pancreas, defined as pancreatic tissue that totally or partly encircles the duodenum, usually the descending portion. A 76-year-old man who was diagnosed with gastric cancer cT3N0M0 Stage IIB underwent laparoscopic distal gastrectomy with D2 lymph node dissection. Intraoperatively, the dorsal half of the duodenal bulb was seen to be half surrounded by the pancreas, and a non-typical annular pancreas was diagnosed. Because of the risk to the pancreas, it was considered impossible to perform anastomosis by a linear stapler as in the usual laparoscopic procedure. Therefore, we performed laparoscopically assisted distal gastrectomy and Billroth-I reconstruction using a circular stapler, and the surgery was completed without difficulties. His postoperative course was good despite the development of a pancreatic fistula, which was an International Study Group for Pancreas Fistula biochemical leak. Some APs can be diagnosed preoperatively, but the rarer subtypes such as ours are more difficult to visualize on imaging. In gastrectomy, it is both oncologically important and technically challenging to perform lymph node dissection around the pancreas. In this case with an especially proximal pancreas, a circular stapler was considered better suited for gastroduodenal anastomosis and required a broader field than that afforded by laparoscopy. A case of non-typical annular pancreas diagnosed during laparoscopic gastric surgery is described. |
| キーワード | annular pancreas gastric cancer laparoscopic distal gastrectomye |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-02 |
| 巻 | 77巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 91 |
| 終了ページ | 95 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36849152 |
| Web of Science KeyUT | 000952978000002 |
| JaLCDOI | 10.18926/AMO/64365 |
|---|---|
| フルテキストURL | 77_1_75.pdf |
| 著者 | Iwamuro, Masaya| Tanaka, Takehiro| Hamada, Kenta| Kono, Yoshiyasu| Kanzaki, Hiromitsu| Kawano, Seiji| Kawahara, Yoshiro| Okada, Hiroyuki| |
| 抄録 | Herein, we report two patients with autoimmune gastritis who had undergone multiple esophagogastroduodenoscopy procedures for 17 and 9 years, respectively, before their diagnosis. Instead, they had been diagnosed with and treated for Helicobacter pylori-associated gastritis. The correct diagnosis was made when scatterings of tiny whitish protrusions in the gastric mucosa were detected on esophagogastroduodenoscopy. Our findings suggest that scattered tiny whitish bumps may be a clue to the diagnosis of autoimmune gastritis. |
| キーワード | autoimmune gastritis esophagogastroduodenoscopy scattered lesions small white protrusions mucosal lesions |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-02 |
| 巻 | 77巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 75 |
| 終了ページ | 80 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36849149 |
| Web of Science KeyUT | 000952973200001 |
| JaLCDOI | 10.18926/AMO/64363 |
|---|---|
| フルテキストURL | 77_1_65.pdf |
| 著者 | Sato, Ken| Takigawa, Nagio| Kubo, Toshio| Katayama, Hideki| Kishino, Daizo| Okada, Toshiaki| Hisamoto, Akiko| Mimoto, Junko| Ochi, Nobuaki| Yoshino, Tadashi| Ueoka, Hiroshi| Tanimoto, Mitsune| Maeda, Yoshionobu| Kiura, Katsuyuki| |
| 抄録 | We investigated the effects of celecoxib combined with (−)-epigallocatechin-3-gallate (EGCG) or polyphenon E in a cisplatin-induced lung tumorigenesis model. Four-week-old female A/J mice were divided into seven groups: (i) Control, (ii) 150 mg/kg celecoxib (150Cel), (iii) 1,500 mg/kg celecoxib (1500Cel), (iv) EGCG+150 mg/kg celecoxib (EGCG+150Cel), (v) EGCG+1,500 mg/kg celecoxib (EGCG+1500Cel), (vi) polyphenon E+150 mg/kg celecoxib (PolyE+150Cel), and (vii) polyphenon E+1,500 mg/kg celecoxib (PolyE+1500Cel). All mice were administered cisplatin (1.62 mg/kg of body weight, i.p.) 1×/week for 10 weeks and sacrificed at week 30; the numbers of tumors on the lung surface were then determined. The tumor incidence and multiplicity (no. of tumors/mouse, mean±SD) were respectively 95% and 2.15±1.50 in Control, 95% and 2.10±1.29 in 150Cel, 86% and 1.67±1.20 in 1500Cel, 71% and 1.38±1.24 in EGCG+150Cel, 67% and 1.29±1.38 in EGCG+1500Cel, 80% and 1.95±1.36 in PolyE+150Cel, and 65% and 1.05±0.10 in PolyE+1500Cel. The combination of high-dose celecoxib with EGCG or polyphenon E significantly reduced multiplicity in cisplatin-induced lung tumors. |
| キーワード | celecoxib cisplatin EGCG lung tumor polyphenon E |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-02 |
| 巻 | 77巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 65 |
| 終了ページ | 70 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36849147 |
| Web of Science KeyUT | 000952992100004 |