検索結果 - 岡山大学学術成果リポジトリ

Prognostic nutritional index is a prognostic factor for patients with gastric cancer and esophagogastric junction cancer undergoing proximal gastrectomy with esophagogastrostomy by the double-flap technique: A secondary analysis of the rD-FLAP study

フルテキストURL	fulltext20231030-01.pdf fig20231030-01.pdf table20231030-01.pdf suppl20231030-01.pdf
著者	Kakiuchi, Yoshihiko\| Kuroda, Shinji\| Choda, Yasuhiro\| Otsuka, Shinya\| Ueyama, Satoshi\| Tanaka, Norimitsu\| Muraoka, Atsushi\| Hato, Shinji\| Kamikawa, Yasuaki\| Fujiwara, Toshiyoshi\|
キーワード	Double -flap technique Gastric cancer Prognostic factor Prognostic nutritional index Proximal gastrectomy
備考	© 2023 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/\| This fulltext file will be available in Sep. 2024.\|
発行日	2023-10
出版物タイトル	Surgical Oncology
巻	50巻
出版者	Elsevier BV
開始ページ	101990
ISSN	0960-7404
NCID	AA10850448
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 Elsevier Ltd.
論文のバージョン	author
PubMed ID	37717376
DOI	10.1016/j.suronc.2023.101990
Web of Science KeyUT	001082185900001
関連URL	isVersionOf https://doi.org/10.1016/j.suronc.2023.101990

Surgical Strategies to Approaching the Splenic Artery in Robotic Distal Pancreatectomy

フルテキストURL	fulltext.pdf
著者	TAKAGI, KOSEI\| KUMANO, KENJIRO\| UMEDA, YUZO\| YOSHIDA, RYUICHI\| FUJI, TOMOKAZU\| YASUI, KAZUYA\| YAGI, TAKAHITO\| FUJIWARA, TOSHIYOSHI\|
キーワード	Robot distal pancreatectomy surgical approach splenic artery pancreatic cancer
発行日	2022-08-23
出版物タイトル	Anticancer Research
巻	42巻
号	9号
出版者	Anticancer Research USA Inc.
開始ページ	4471
終了ページ	4476
ISSN	0250-7005
NCID	AA10625860
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 International Institute of Anticancer Research (Dr. George J. Delinasios)
論文のバージョン	publisher
PubMed ID	36039441
DOI	10.21873/anticanres.15947
Web of Science KeyUT	000848585700012
関連URL	isVersionOf https://doi.org/10.21873/anticanres.15947

Favorable Outcome of Repeated Salvage Surgeries for Rare Metastasis to the Ligamentum Teres Hepatis and the Upper Abdominal Wall in a Stage IV Gastric Cancer Patient

JaLCDOI	10.18926/AMO/65979
フルテキストURL	77_5_553.pdf
著者	Murokawa, Takahiro\| Sakamoto, Shinya\| Tabuchi, Motoyasu\| Sui, Kenta\| Ozaki, Kazuhide\| Matsumoto, Manabu\| Iwata, Jun\| Okabayashi, Takehiro\| Yoshida, Hiroshi\|
抄録	Gastric cancer with peritoneal metastases is typically a devastating diagnosis. Ligamentum teres hepatis (LTH) metastasis is an extremely rare presentation with only four known cases. Herein, we report salvage surgery of successive metastases to the abdominal wall and LTH in a patient originally presenting with advanced gastric cancer with peritoneal metastasis, leading to long-term survival. A 72-year-old man with advanced gastric cancer underwent curative-intent distal gastrectomy with D2 lymph node dissection for gastric outlet obstruction. During this procedure, three small peritoneal metastases were detected in the lesser omentum, the small mesentery, and the mesocolon; however, intraoperative abdominal lavage cytology was negative. We added cytoreductive surgery for peritoneal metastasis. The pathological diagnosis of the gastric cancer was tubular adenocarcinoma with pT4aN1pM1(PER/P1b)CY0 stage IV (Japanese classification of gastric carcinoma/JCGC 15th), or T4N1M1b stage IV (UICC 7th). Post-operative adjuvant chemotherapy with S-1 (TS-1)+cisplatin (CDDP) was administered for 8 months followed by S-1 monotherapy for 4 months. At 28 months after the initial surgery, a follow-up computed tomography (CT) detected a small mass beneath the upper abdominal wall. The ass showed mild avidity on 18F-fluorodeoxyglucose positron-emission (FDG-PET) CT. Salvage resection was performed for diagnosis and treatment, and pathological findings were consistent with primary gastric cancer metastasis. At 49 months after the initial gastrectomy, a new lesion was detected in the LTH with a similar level of avidity on FDG-PET CT as the abdominal wall metastatic lesion. We performed a second salvage surgery for the LTH tumor, which also showed pathology of gastric cancer metastasis. There has been no recurrence up to 1 year after the LTH surgery. With multidisciplinary treatment the patient has survived almost 5 years after the initial gastrectomy. Curative-intent gastrectomy with cytoreductive surgery followed by adjuvant chemotherapy for advanced gastric cancer with localized peritoneal metastasis might have had a survival benefit in our patient. Successive salvage surgeries for oligometastatic lesions in the abdominal wall and the LTH also yielded favorable outcomes.
キーワード	gastric cancer peritoneal metastasis ligamentum teres hepatis oligometastasis salvage surgery
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2023-10
巻	77巻
号	5号
出版者	Okayama University Medical School
開始ページ	553
終了ページ	559
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37899267
Web of Science KeyUT	001110832700001

Endoscopic Manifestations and Clinical Characteristics of Localized Gastric Light-Chain Amyloidosis

JaLCDOI	10.18926/AMO/65978
フルテキストURL	77_5_545.pdf
著者	Iwamuro, Masaya\| Tanaka, Shouichi\| Toyokawa, Tatsuya\| Nishimura, Mamoru\| Tsuzuki, Takao\| Miyahara, Koji\| Negishi, Shin\| Ohya, Shogen\| Tanaka, Takehiro\| Otsuka, Motoyuki\|
抄録	To determine the endoscopic and clinical features of localized gastric amyloid light-chain (AL) amyloidosis, we retrospectively examined the characteristics of nine patients (eight men and one woman) encountered by the hospitals in our network. Lesions were predominantly flat and depressed with surface vascular dilatation (n=5); others were characterized by subepithelial lesions (n=2), mucosal color change (n=1), and a mass-like morphology with swollen mucosal folds (n=1). Colonoscopy (n=7), video capsule enteroscopy (n=2), serum (n=5) and urine immunoelectrophoresis (n=4), and bone marrow examination (n=3) were performed to exclude involvement of organs other than the stomach. As treatment for gastric lesions of AL amyloidosis, one patient each underwent endoscopic submucosal dissection (n=1) and argon plasma coagulation (n=1), while the remaining seven patients underwent no specific treatment. During a mean follow-up of 4.2 years, one patient died 3.2 years after diagnosis, but the cause of death, which occurred in another hospital, was unknown. The remaining eight patients were alive at the last visit. In conclusion, although localized gastric AL amyloidosis can show various macroscopic features on esophagogastroduodenoscopy, flat, depressed lesions with vascular dilatation on the surface are predominant.
キーワード	esophagogastroduodenoscopy gastric lesion amyloidosis light chain
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-10
巻	77巻
号	5号
出版者	Okayama University Medical School
開始ページ	545
終了ページ	552
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37899266
Web of Science KeyUT	001094245100001

Association between BRCA Gene Variants and the Response to Modified FOLFIRINOX in Patients with Unresectable Pancreatic Cancer

JaLCDOI	10.18926/AMO/65974
フルテキストURL	77_5_517.pdf
著者	Horiguchi, Shigeru\| Matsumoto, Kazuyuki\| Morimoto, Kosaku\| Matsumi, Akihiro\| Terasawa, Hiroyuki\| Fujii, Yuki\| Yamazaki, Tatsuhiro\| Tsutsumi, Koichiro\| Kato, Hironari\|
抄録	We investigated the effect of modified FOLFIRINOX (mFFX) in unresectable pancreatic cancer by retrospectively analyzing the cases of 43 patients who underwent BRCA testing (germline, n=11; somatic, n=26; both germline and somatic, n=6). The association between BRCA mutations and therapeutic effect was clarified. Six patients tested positive for germline pathogenic variants. Familial pancreatic cancer (33% vs. 3%, p=0.006) and peritoneal disseminated lesions (66% vs. 8%, p<0.001) were significantly more common in patients with germline pathogenic variants. The partial response (PR) rate was 100% in the germline BRCA-positive patients, and 27% in the germline BRCA-negative patients (p<0.001). The median progression-free survival (PFS) was not reached for any germline BRCA-positive patients but was 9.0 months for the germline BRCA-negative patients (p=0.042). Patients with stage IV BRCA-associated pancreatic cancer had better overall survival than those with non-BRCA-associated pancreatic cancer, although the difference was nonsignificant (not reached vs. 655 days, p=0.061). Our results demonstrate that a PR and prolonged PFS can be expected in germline BRCA-positive patients after treatment with mFFX. Our findings also suggest that germline BRCA pathogenic variants may be useful as biomarkers for the therapeutic effect of mFFX in patients with pancreatic cancer.
キーワード	BRCA FOLFIRINOX pancreatic cancer progression-free survival pathogenic variant
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-10
巻	77巻
号	5号
出版者	Okayama University Medical School
開始ページ	517
終了ページ	525
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37899263
Web of Science KeyUT	001108661600009

Low Patient Weight and Long Intubation Time Are Key Factors for Pain during Colonoscopy

JaLCDOI	10.18926/AMO/65969
フルテキストURL	77_5_471.pdf
著者	Oka, Shohei\| Harada, Keita\| Yamamoto, Shumpei\| Yasutomi, Eriko\| Igawa, Shoko\| Ohmori, Masayasu\| Hirai, Mami\| Yamasaki, Yasushi\| Inokuchi, Toshihiro\| Kinugasa, Hideaki\| Takahara, Masahiro\| Hiraoka, Sakiko\| Okada, Hiroyuki\|
抄録	Although the clinical usefulness of colonoscopy has been established, the procedure remains painful for many patients. This study was designed to clarify the factors predicting colonoscopy-related pain. We evaluated 283 consecutive patients who completed a first-ever, total colonoscopy without sedatives or analgesics. The severity of pain symptoms was evaluated by a numeric rating scale (NRS) in a questionnaire immediately after the colonoscopy. Patient backgrounds and endoscopic findings were analyzed to evaluate their association with pain. Out of 283 patients, 53 scored their pain 0-1 on the NRS while 48 scored it 6-10. We defined the colonoscopies of the former and latter patients as painless and painful, respectively, and compared the two. Multivariate analyses revealed that low body weight (OR 4.95, 95%CI 1.89-12.99) and longer intubation time (OR 3.63, 95%CI 1.46-9.03) were significant risk factors for painful colonoscopy. To identify factors contributing to the increased intubation time, we divided subjects into short- and long-intubation-time groups based on a median insertion time of 7 min. Older age (OR 2.28, 95%CI 1.31-3.98), previous abdominal surgery (OR 1.93, 95%CI 1.13-3.32) and findings of invasive cancer (OR 10.90, 95%CI 1.34-88.90) were significant factors for longer intubation time.
キーワード	colonoscopy colonoscopy-related pain comfortable colonoscopy
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-10
巻	77巻
号	5号
出版者	Okayama University Medical School
開始ページ	471
終了ページ	478
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37899258
Web of Science KeyUT	001108661600004

The efficacy of non-anesthesiologist-administered propofol sedation with a target-controlled infusion system during double-balloon endoscopic retrograde cholangiopancreatography

フルテキストURL	fulltext.pdf
著者	Miyamoto, Kazuya\| Matsumoto, Kazuyuki\| Obata, Taisuke\| Sato, Ryosuke\| Matsumi, Akihiro\| Morimoto, Kosaku\| Ogawa, Taiji\| Terasawa, Hiroyuki\| Fujii, Yuki\| Yamazaki, Tatsuhiro\| Uchida, Daisuke\| Horiguchi, Shigeru\| Tsutsumi, Koichiro\| Kato, Hironari\| Otsuka, Motoyuki\|
キーワード	Balloon-assisted endoscopy Propofol Diazepam Sedation
備考	The version of record of this article, first published in BMC Gastroenterology, is available online at Publisher’s website: http://dx.doi.org/10.1186/s12876-023-02936-8\|
発行日	2023-09-04
出版物タイトル	BMC Gastroenterology
巻	23巻
号	1号
出版者	BMC
開始ページ	296
ISSN	1471-230X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2023.
論文のバージョン	publisher
PubMed ID	37667224
DOI	10.1186/s12876-023-02936-8
Web of Science KeyUT	001063014700002
関連URL	isVersionOf https://doi.org/10.1186/s12876-023-02936-8

Comparison of Bilateral and Trisegment Drainage in Patients with High-Grade Hilar Malignant Biliary Obstruction: A Multicenter Retrospective Study

フルテキストURL	fulltext.pdf
著者	Matsumoto, Kazuyuki\| Kato, Hironari\| Morimoto, Kosaku\| Miyamoto, Kazuya\| Saragai, Yosuke\| Kawamoto, Hirofumi\| Okada, Hiroyuki\|
キーワード	Bile duct obstruction Neoplasms Endoscopic biliary drainage Bilateral drainage Self-expandable metallic stents
発行日	2022-07-19
出版物タイトル	Gut and Liver
巻	17巻
号	1号
出版者	The Editorial Office of Gut and Liver
開始ページ	170
終了ページ	178
ISSN	1976-2283
NCID	AA12329814
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© Gut and Liver.
論文のバージョン	publisher
PubMed ID	35851039
DOI	10.5009/gnl220012
Web of Science KeyUT	000830704600001
関連URL	isVersionOf https://doi.org/10.5009/gnl220012

Diagnostic Utility of the PD-L1 Immunostaining in Biopsy Specimens of Patients with Biliary Tract Neoplasms

フルテキストURL	fulltext.pdf
著者	Matsumoto, Kazuyuki\| Ohara, Toshiaki\| Fujisawa, Masayoshi\| Takaki, Akinobu\| Takahara, Masahiro\| Kato, Hironari\| Yoshida, Ryuichi\| Umeda, Yuzo\| Yagi, Takahito\| Matsukawa, Akihiro\| Okada, Hiroyuki\|
キーワード	Programmed death ligand 1 Bile tract neoplasm Biopsy specimen Immunohistochemistry
備考	The version of record of this article, first published in Journal of Gastrointestinal Surgery, is available online at Publisher’s website: http://dx.doi.org/10.1007/s11605-021-05197-6\|
発行日	2022-02-08
出版物タイトル	Journal of Gastrointestinal Surgery
巻	26巻
号	6号
出版者	Springer Science and Business Media LLC
開始ページ	1213
終了ページ	1223
ISSN	1091-255X
NCID	AA11494553
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2022
論文のバージョン	publisher
PubMed ID	35137343
DOI	10.1007/s11605-021-05197-6
Web of Science KeyUT	000752761400001
関連URL	isVersionOf https://doi.org/10.1007/s11605-021-05197-6

Mixed Response to Cancer Immunotherapy is Driven by Intratumor Heterogeneity and Differential Interlesion Immune Infiltration

フルテキストURL	fulltext.pdf
著者	Morinaga, Takao\| Inozume, Takashi\| Kawazu, Masahito\| Ueda, Youki\| Sax, Nicolas\| Yamashita, Kazuo\| Kawashima, Shusuke\| Nagasaki, Joji\| Ueno, Toshihide\| Lin, Jason\| Ohara, Yuuki\| Kuwata, Takeshi\| Yukami, Hiroki\| Kawazoe, Akihito\| Shitara, Kohei\| Honobe-Tabuchi, Akiko\| Ohnuma, Takehiro\| Kawamura, Tatsuyoshi\| Umeda, Yoshiyasu\| Kawahara, Yu\| Nakamura, Yasuhiro\| Kiniwa, Yukiko\| Morita, Ayako\| Ichihara, Eiki\| Kiura, Katsuyuki\| Enokida, Tomohiro\| Tahara, Makoto\| Hasegawa, Yoshinori\| Mano, Hiroyuki\| Suzuki, Yutaka\| Nishikawa, Hiroyoshi\| Togashi, Yosuke\|
発行日	2022-07-28
出版物タイトル	Cancer Research Communications
巻	2巻
号	7号
出版者	American Association for Cancer Research
開始ページ	739
終了ページ	753
ISSN	2767-9764
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 The Authors
論文のバージョン	publisher
PubMed ID	36923281
DOI	10.1158/2767-9764.CRC-22-0050
Web of Science KeyUT	001048412300001
関連URL	isVersionOf https://doi.org/10.1158/2767-9764.CRC-22-0050

Review of oral and pharyngolaryngeal benign lesions detected during esophagogastroduodenoscopy

フルテキストURL	fulltext20230911-01.pdf
著者	Iwamuro, Masaya\| Hamada, Kenta\| Kawano, Seiji\| Kawahara, Yoshiro\| Otsuka, Motoyuki\|
キーワード	Benign diseases Diagnosis Esophagogastroduodenoscopy Non-neoplastic lesions Oral lesions Pharyngolaryngeal lesions
発行日	2023-07-16
出版物タイトル	World Journal of Gastrointestinal Endoscopy
巻	15巻
号	7号
出版者	Baishideng Publishing Group Inc.
開始ページ	496
終了ページ	509
ISSN	1948-5190
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	©The Author(s) 2023.
論文のバージョン	publisher
PubMed ID	37547241
DOI	10.4253/wjge.v15.i7.496
Web of Science KeyUT	001046453000002
関連URL	isVersionOf https://doi.org/10.4253/wjge.v15.i7.496

Endoscopic removal of proximally migrated stents using a double-balloon enteroscope in patients with bowel reconstruction (with video)

フルテキストURL	fulltext.pdf
著者	Oda, Takashi\| Matsumoto, Kazuyuki\| Ueta, Eijiro\| Himei, Hitomi\| Ogawa, Taiji\| Terasawa, Hiroyuki\| Fujii, Yuki\| Yamazaki, Tatsuhiro\| Horiguchi, Shigeru\| Tsutsumi, Koichiro\| Kato, Hironari\| Okada, Hiroyuki\|
キーワード	double-balloon enteroscope (DBE) stent migration stent removal
発行日	2021-09-07
出版物タイトル	DEN Open
巻	2巻
号	1号
出版者	Wiley
開始ページ	e32
ISSN	2692-4609
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 The Authors.
論文のバージョン	publisher
PubMed ID	35310742
DOI	10.1002/deo2.32
Web of Science KeyUT	001047024900041
関連URL	isVersionOf https://doi.org/10.1002/deo2.32

Fever and electrocoagulation syndrome after colorectal endoscopic submucosal dissection for patients with immunosuppressants and steroids

フルテキストURL	fulltext.pdf
著者	Yamamoto, Shumpei\| Kinugasa, Hideaki\| Yamasaki, Yasushi\| Hirai, Mami\| Ako, Soichiro\| Takei, Kensuke\| Igawa, Shoko\| Yasutomi, Eriko\| Oka, Shohei\| Ohmori, Masayasu\| Inokuchi, Toshihiro\| Harada, Keita\| Hiraoka, Sakiko\| Nouso, Kazuhiro\| Tanaka, Takehiro\| Okada, Hiroyuki\|
キーワード	colorectal ESD PECS electrocoagulation syndrome immunosuppressants and steroids post-ESD fever
発行日	2021-12-09
出版物タイトル	DEN Open
巻	2巻
号	1号
出版者	Wiley
開始ページ	e83
ISSN	2692-4609
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 The Authors.
論文のバージョン	publisher
PubMed ID	35310725
DOI	10.1002/deo2.83
Web of Science KeyUT	001047024900091
関連URL	isVersionOf https://doi.org/10.1002/deo2.83

Recent advances regarding endoscopic biliary drainage for unresectable malignant hilar biliary obstruction

フルテキストURL	fulltext.pdf
著者	Kato, Hironari\| Matsumoto, Kazuyuki\| Okada, Hiroyuki\|
キーワード	biliary drainage EUS-BD malignant hilar biliary obstruction side-by-side stent-in-stent
発行日	2021-09-07
出版物タイトル	DEN Open
巻	2巻
号	1号
出版者	Wiley
開始ページ	e33
ISSN	2692-4609
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 The Authors.
論文のバージョン	publisher
PubMed ID	35310763
DOI	10.1002/deo2.33
Web of Science KeyUT	001047024900042
関連URL	isVersionOf https://doi.org/10.1002/deo2.33

Prospective multicenter study of the efficacy and safety of cold forceps polypectomy for ≤ 6-mm non-ampullary duodenal low-grade adenomas

フルテキストURL	fulltext.pdf
著者	Kanzaki, Hiromitsu\| Horii, Joichiro\| Takenaka, Ryuta\| Nakagawa, Hiroyuki\| Matsueda, Kazuhiro\| Tsuzuki, Takao\| Kita, Masahide\| Yamasaki, Yasushi\| Tanaka, Takehiro\| Iwamuro, Masaya\| Kawano, Seiji\| Kawahara, Yoshiro\| Tomoda, Jun\| Okada, Hiroyuki\|
発行日	2022-06-10
出版物タイトル	Endoscopy International Open
巻	10巻
号	06号
出版者	Georg Thieme Verlag KG
開始ページ	E712
終了ページ	E718
ISSN	2364-3722
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022. The Author(s).
論文のバージョン	publisher
PubMed ID	35859656
DOI	10.1055/a-1793-9439
Web of Science KeyUT	000826506700001
関連URL	isVersionOf https://doi.org/10.1055/a-1793-9439

Prognostic risk factors for postoperative long-term outcomes in elderly stage IA gastric cancer patients

フルテキストURL	fulltext.pdf
著者	Kakiuchi, Yoshihiko\| Kuroda, Shinji\| Kikuchi, Satoru\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
キーワード	Gastric cancer (GC) elderly stage IA comorbidity Charlson comorbidity index (CCI)
発行日	2022-10
出版物タイトル	Journal of Gastrointestinal Oncology
巻	13巻
号	5号
出版者	AME Publishing Company
開始ページ	2178
終了ページ	2185
ISSN	2078-6891
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© Journal of Gastrointestinal Oncology.
論文のバージョン	publisher
PubMed ID	36388703
DOI	10.21037/jgo-22-527
Web of Science KeyUT	000864732300001
関連URL	isVersionOf https://doi.org/10.21037/jgo-22-527

令和４年度岡山医学会賞　がん研究奨励賞（林原賞・山田賞）

タイトル（別表記）	The 2022 Incentive Award of the Okayama Medical Association in Cancer Research (2022 Hayashibara Prize and Yamada Prize)
著者	白川靖博\|
出版物タイトル	岡山医学会雑誌
発行日	2023-08-01
巻	135巻
号	2号
開始ページ	58
終了ページ	60
ISSN	0030-1558
関連URL	isVersionOf https://doi.org/10.4044/joma.135.58
言語	日本語
著作権者	Copyright (c) 2023 岡山医学会
論文のバージョン	publisher
DOI	10.4044/joma.135.58

An Unusual Presentation of Chest Pain and Laryngeal Discomfort in a Pregnant Woman: A Case Report and Literature Review

JaLCDOI	10.18926/AMO/65755
フルテキストURL	77_4_429.pdf
著者	Sasanami, Misa\| Iida, Atsuyoshi\| Iwamuro, Masaya\| Hirai, Ryousuke\| Obara, Takashi\| Tsukahara, Kohei\| Yumoto, Tetsuya\| Naito, Hiromichi\| Nakao, Atsunori\|
抄録	Intramural esophageal dissection (IED), characterized by bleeding into the submucosal space, leads to mucosal separation and dissection. The most prevalent symptoms are sudden chest or retrosternal pain, hematemesis, and dysphagia. Therefore, acute coronary syndrome and aortic dissection are among its most notable differential diagnoses. A 31-year-old pregnant woman presented with acute chest pain, laryngeal discomfort, and hematemesis. Emergency esophagogastroscopy revealed longitudinal mucosal dissection (upper esophagus to esophagogastric junction). The patient was successfully treated by avoiding the ingestion of solid foods. Clinicians should consider a diagnosis of IED for pregnant patients with acute chest pain, especially if hematemesis is present.
キーワード	chest pain dysphagia esophageal dissection hematemesis
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2023-08
巻	77巻
号	4号
出版者	Okayama University Medical School
開始ページ	429
終了ページ	431
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37635144
Web of Science KeyUT	001163659800012

Disease Progression-Related Markers for Aged Non-Alcoholic Fatty Liver Disease Patients

JaLCDOI	10.18926/AMO/65748
フルテキストURL	77_4_377.pdf
著者	Morimoto, Kosaku\| Takeuchi, Yasuto\| Takaki, Akinobu\| Wada, Nozomu\| Oyama, Atsushi\| Adachi, Takuya\| Onishi, Hideki\| Shiraha, Hidenori\| Okada, Hiroyuki\|
抄録	Liver fibrosis is an important phenomenon in non-alcoholic fatty liver disease (NAFLD) progression. Standard markers reflecting liver fibrosis, including the FIB-4 index, increase with age. This study aimed to identify fibrosis progression-related markers that are diagnostically beneficial even in aged individuals. Serum levels of pro- and anti-inflammatory cytokines were measured by multiple enzyme-linked immunosorbent assay. Two standard NAFLD or fibrosis progression-related markers — the FIB-4 index and APRI score — were analyzed along with cytokine levels to define the best approach to discriminate advanced fibrosis. Ninety-eight NAFLD patients were enrolled: 59 and 39 patients with fibrosis stages 1-2 and 3-4 respectively. In addition to the FIB-4 index and APRI score, the following factors showed significant differences between stages 1-2 and stages 3-4 in a multivariate analysis: platelet counts, IP-10, and RANTES. The fibrosis stage, FIB-4, APRI, PDGF-BB, and RANTES were related to the prognosis. In aged patients, IP-10, GM-CSF, and RANTES differed between stages 1-2 and stages 3-4. FIB-4 and APRI were beneficial for their correlation with fibrosis. However, to stratify either young or elderly advanced fibrosis patients, and to identify patients likely to have a bad outcome, RANTES was the best marker.
キーワード	NAFLD NASH liver fibrosis chemokine FIB-4
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-08
巻	77巻
号	4号
出版者	Okayama University Medical School
開始ページ	377
終了ページ	385
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37635138
Web of Science KeyUT	001163659800009

Feasibility of Flow Cytometry Analysis of Gastrointestinal Tract-Residing Lymphocytes in Hematopoietic Stem Cell Transplant Recipients

JaLCDOI	10.18926/AMO/65740
フルテキストURL	77_4_347.pdf
著者	Iwamuro, Masaya\| Kondo, Takumi\| Ennishi, Daisuke\| Fujii, Nobuharu\| Matsuoka, Ken-ichi\| Takahashi, Takahide\| Hirabata, Araki\| Tanaka, Takehiro\| Otsuka, Fumio\| Maeda, Yoshinobu\| Okada, Hiroyuki\|
抄録	The feasibility of lymphocyte isolation and flow cytometry using a single endoscopic biopsy specimen from the gastrointestinal tract of patients who have undergone hematopoietic stem cell transplantation has not been investigated. We acquired 51 endoscopic biopsy specimens from the gastrointestinal tract of 35 patients. We divided the flow cytometry samples into two groups: group A, successful lymphocyte isolation (n=24), and group B, incomplete isolation (n=27). We compared the backgrounds of the samples between the groups to reveal crucial elements in the successful isolation of lymphocytes residing in the gastrointestinal tract. Comparison between the groups revealed lymphocyte isolation success rates differed between biopsy sites. Isolation was most successful in samples from the duodenum (8/9, 88.9%), followed by the ileum (4/8, 50.0%), large intestine (4/11, 36.4%), and stomach (8/23, 34.8%). Tacrolimus was used more frequently in group B (92.6%) than in group A (62.5%) (p=0.015). Logistic regression analysis revealed that isolation from the duodenum or ileum was a significant factor for successful isolation, while tacrolimus use was not statistically significant. In conclusion, the duodenum and ileum are more suitable sites than the stomach and colorectum for acquiring samples for flow cytometry.
キーワード	flow cytometry stem cell transplantation transplantation-associated microangiopathy
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-08
巻	77巻
号	4号
出版者	Okayama University Medical School
開始ページ	347
終了ページ	357
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37635134
Web of Science KeyUT	001163659800002