検索結果 47840 件
| JaLCDOI | 10.18926/49058 |
|---|---|
| タイトル（別表記） | James Joyce and St. Catherine’s Church －The Rationale Underlying Joyce's Decision for Setting the Church as the Centre Stage in The Sisters － |
| フルテキストURL | hss_034_143_162.pdf |
| 著者 | 金田 法子| |
| 出版物タイトル | 岡山大学大学院社会文化科学研究科紀要 |
| 発行日 | 2012-11-26 |
| 巻 | 34巻 |
| 開始ページ | 143 |
| 終了ページ | 162 |
| ISSN | 1881-1671 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2012 岡山大学大学院社会文化科学研究科 |
| 論文のバージョン | publisher |
| NAID | 40019507178 |
| JaLCDOI | 10.18926/49057 |
|---|---|
| タイトル（別表記） | Geographical Studies of Local Industry after the 1990s：Achievements and Problems |
| フルテキストURL | hss_034_123_142.pdf |
| 著者 | 塚本 僚平| |
| 出版物タイトル | 岡山大学大学院社会文化科学研究科紀要 |
| 発行日 | 2012-11-26 |
| 巻 | 34巻 |
| 開始ページ | 123 |
| 終了ページ | 142 |
| ISSN | 1881-1671 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2012 岡山大学大学院社会文化科学研究科 |
| 論文のバージョン | publisher |
| NAID | 40019507173 |
| JaLCDOI | 10.18926/49056 |
|---|---|
| タイトル（別表記） | The Palestine Problem in 1947 －A Case Study of the Operations of UNSCOP － |
| フルテキストURL | hss_034_107_122.pdf |
| 著者 | 佐藤 寛和| |
| 出版物タイトル | 岡山大学大学院社会文化科学研究科紀要 |
| 発行日 | 2012-11-26 |
| 巻 | 34巻 |
| 開始ページ | 107 |
| 終了ページ | 122 |
| ISSN | 1881-1671 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2012 岡山大学大学院社会文化科学研究科 |
| 論文のバージョン | publisher |
| NAID | 40019507170 |
| JaLCDOI | 10.18926/49055 |
|---|---|
| タイトル（別表記） | Expressions of Maiko in SUGAWARA Michizane －Focusing on the acceptance of the expression of traditional Chinese dances in the poems of BAI Juyi－ |
| フルテキストURL | hss_034_091_105.pdf |
| 著者 | 潘 怡良| |
| 出版物タイトル | 岡山大学大学院社会文化科学研究科紀要 |
| 発行日 | 2012-11-26 |
| 巻 | 34巻 |
| 開始ページ | 91 |
| 終了ページ | 105 |
| ISSN | 1881-1671 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2012 岡山大学大学院社会文化科学研究科 |
| 論文のバージョン | publisher |
| NAID | 40019507166 |
| JaLCDOI | 10.18926/49054 |
|---|---|
| タイトル（別表記） | The Research Note about the Background of the Cultural Adaptation Problems of Foreign Nurses and Care Worker Candidates in Japan －From the View of EPA Systems and Its Circumstances－ |
| フルテキストURL | hss_034_079_090.pdf |
| 著者 | 畠中 香織| 田中 共子| |
| 出版物タイトル | 岡山大学大学院社会文化科学研究科紀要 |
| 発行日 | 2012-11-26 |
| 巻 | 34巻 |
| 開始ページ | 79 |
| 終了ページ | 90 |
| ISSN | 1881-1671 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2012 岡山大学大学院社会文化科学研究科 |
| 論文のバージョン | publisher |
| NAID | 40019507154 |
| JaLCDOI | 10.18926/49053 |
|---|---|
| タイトル（別表記） | Mongolian Obo Culture and its Transfiguration in the Inner Mongolia |
| フルテキストURL | hss_034_061_078.pdf |
| 著者 | 王 桂蘭| |
| 出版物タイトル | 岡山大学大学院社会文化科学研究科紀要 |
| 発行日 | 2012-11-26 |
| 巻 | 34巻 |
| 開始ページ | 61 |
| 終了ページ | 78 |
| ISSN | 1881-1671 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2012 岡山大学大学院社会文化科学研究科 |
| 論文のバージョン | publisher |
| NAID | 40019507144 |
| JaLCDOI | 10.18926/49052 |
|---|---|
| タイトル（別表記） | Grammaticalization of Conditional Forms on the Verb “iu” －Focussing Mainly on the Case of Quoting Noun Phrases－ |
| フルテキストURL | hss_034_047_059.pdf |
| 著者 | 陳 新妍| |
| 出版物タイトル | 岡山大学大学院社会文化科学研究科紀要 |
| 発行日 | 2012-11-26 |
| 巻 | 34巻 |
| 開始ページ | 47 |
| 終了ページ | 59 |
| ISSN | 1881-1671 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2012 岡山大学大学院社会文化科学研究科 |
| 論文のバージョン | publisher |
| NAID | 40019507136 |
| JaLCDOI | 10.18926/49051 |
|---|---|
| フルテキストURL | hss_034_033_045.pdf |
| 著者 | 吉岡 文夫| |
| 出版物タイトル | 岡山大学大学院社会文化科学研究科紀要 |
| 発行日 | 2012-11-26 |
| 巻 | 34巻 |
| 開始ページ | 33 |
| 終了ページ | 45 |
| ISSN | 1881-1671 |
| 言語 | 英語 |
| 著作権者 | Copyright © 2012 岡山大学大学院社会文化科学研究科 |
| 論文のバージョン | publisher |
| NAID | 120005121900 |
| JaLCDOI | 10.18926/49050 |
|---|---|
| フルテキストURL | hss_034_013_032.pdf |
| 著者 | 田原 伸子| |
| 出版物タイトル | 岡山大学大学院社会文化科学研究科紀要 |
| 発行日 | 2012-11-26 |
| 巻 | 34巻 |
| 開始ページ | 13 |
| 終了ページ | 32 |
| ISSN | 1881-1671 |
| 言語 | 英語 |
| 著作権者 | Copyright © 2012 岡山大学大学院社会文化科学研究科 |
| 論文のバージョン | publisher |
| NAID | 120005121901 |
| 著者 | 岡山大学大学院社会文化科学研究科| |
|---|---|
| 発行日 | 2012-11-26 |
| 出版物タイトル | 岡山大学大学院社会文化科学研究科紀要 |
| 巻 | 34巻 |
| 資料タイプ | その他 |
| JaLCDOI | 10.18926/49048 |
|---|---|
| タイトル（別表記） | Muse and the Performance of Gender in Paul Auster's The Book of Illusions (2002) |
| フルテキストURL | hss_034_001_012.pdf |
| 著者 | 中谷 ひとみ| |
| キーワード | Alma Grund Clair Martin Frieda Spelling ジェンダー 新しいミューズ |
| 出版物タイトル | 岡山大学大学院社会文化科学研究科紀要 |
| 発行日 | 2012-11-26 |
| 巻 | 34巻 |
| 開始ページ | 1 |
| 終了ページ | 12 |
| ISSN | 1881-1671 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2012 岡山大学大学院社会文化科学研究科 |
| 論文のバージョン | publisher |
| NAID | 40019507118 |
| JaLCDOI | 10.18926/AMO/49047 |
|---|---|
| フルテキストURL | 66_6_499.pdf |
| 著者 | Sugimoto, Yoshihisa| Tanaka, Masato| Nakahara, Ryuichi| Misawa, Haruo| Kunisada, Toshiyuki| Ozaki, Toshifumi| |
| 抄録 | An 11 year-old girl had 66 degrees of kyphosis in the thoracolumbar junction. For the purpose of planning for kyphosis correction, we created a 3-D, full-scale model of the spine and consulted spinal navigation. Three-dimensional models are generally used as tactile guides to verify the surgical approach and portray the anatomic relations specific to a given patient. We performed posterior fusion from Th10 to L3, and vertebral column resection of Th12 and L1. Screw entry points, directions, lengths and diameters were determined by reference to navigation. Both tools were useful in the bone resection. We could easily detect the posterior element to be resected using the 3D model. During the anterior bony resection, navigation helped us to check the disc level and anterior wall of the vertebrae, which were otherwise difficult to detect due to their depth in the surgical field. Thus, the combination of navigation and 3D models helped us to safely perform surgery for a patient with complex spinal deformity. |
| キーワード | congenital scoliosis kyphosis navigation 3-dimensional models |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2012-12 |
| 巻 | 66巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 499 |
| 終了ページ | 502 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2012 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23254585 |
| Web of Science KeyUT | 000312966100010 |
| JaLCDOI | 10.18926/AMO/49046 |
|---|---|
| フルテキストURL | 66_6_493.pdf |
| 著者 | Matsuo, Toshihiko| |
| 抄録 | Acute retinal necrosis syndrome (ARNS) is a herpetic infectious eye disease that presents clinicians with difficult decisions to make about the indication and timing of surgical intervention. Here I report 2 patients who underwent prophylactic and early vitrectomy with good visual outcomes. Case 1, a 72-year-old man, had a second recurrence of ARNS in the left eye in 2011 and underwent early vitrectomy in the acute inflammatory phase to remove previously formed vitreous opacity and vitreoretinal adhesions, in parallel with intravenous acyclovir and oral prednisolone administration. He had experienced ARNS in the right eye in 1983, in the left eye in 1986, and a recurrence in the left eye in 1999. Case 2, a 66-year-old woman, developed ARNS in the right eye. All of the circumferential retinal lesions became degenerative with intravenous acyclovir and prednisolone. She underwent a vitrectomy in the post-inflammatory phase, since epiretinal proliferation was noted through vitreous opacity with complete posterior vitreous detachment. These cases suggest that early vitrectomy in the acute inflammatory phase would be indicated for pre-existing vitreoretinal adhesions, while prophylactic vitrectomy in the post-inflammatory phase would be indicated for epiretinal proliferation. |
| キーワード | acute retinal necrosis syndrome (ARNS) early vitrectomy epiretinal proliferation prophylactic vitrectomy herpetic retinitis |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2012-12 |
| 巻 | 66巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 493 |
| 終了ページ | 497 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2012 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23254584 |
| Web of Science KeyUT | 000312966100009 |
| JaLCDOI | 10.18926/AMO/49045 |
|---|---|
| フルテキストURL | 66_6_487.pdf |
| 著者 | Agari, Takashi| Mihara, Tadahiro| Baba, Koichi| Kobayashi, Katsuhiro| Usui, Naotaka| Terada, Kiyohito| Nakamura, Fumihiro| Matsuda, Kazumi| Date, Isao| |
| 抄録 | We report on a case of successful surgical treatment of drug-resistant epilepsy associated with a solitary lesion of periventricular nodular heterotopia (PNH). In the reported patient, intracranial ictal electroencephalography disclosed that seizures did not originate from the heterotopic nodules. However, the seizures were completely suppressed by lesionectomy of PNH alone. Epileptogenesis associated with PNH likely involves a very complex network between PNH and the surrounding cortex, and the disruption of this network may be an effective means of curing intractable, PNH-associated epilepsy. |
| キーワード | periventricular nodular heterotopia epilepsy surgery ictal electroencephalography |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2012-12 |
| 巻 | 66巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 487 |
| 終了ページ | 492 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2012 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23254583 |
| Web of Science KeyUT | 000312966100008 |
| JaLCDOI | 10.18926/AMO/49044 |
|---|---|
| フルテキストURL | 66_6_475.pdf |
| 著者 | Hase, Soichiro| Mitsumori, Akihito| Inai, Ryota| Takemoto, Mitsuhiro| Matsubara, Shinichiro| Akamatsu, Nobuo| Fujisawa, Masayoshi| Joja, Ikuo| Sato, Shuhei| Kanazawa, Susumu| |
| 抄録 | The purpose of this study is to evaluate the diagnostic usefulness of magnetic resonance imaging (MRI) characteristics of endometrial polyps in order to differentiate them from other endometrial lesions. MRI was retrospectively reviewed in 40 patients with pathologically proven endometrial polyps. Special attention was paid to the sizes, shapes, margins, internal structures, signal intensities, and post-contrast enhancement patterns. A central fibrous core, intratumoral cysts, and hemorrhage were seen in 30 (75%), 22 (55%), and 14 (35%) patients, respectively. The predominant signal intensity of the lesions showed iso-to slightly low signal intensity relative to the endometrium on T2-weighted images in 36 (90%), low signal intensity on diffusion-weighted images in 32 (80%), and strong or moderate enhancement on enhanced T1-weighted images in 28 patients (70%), respectively. In 32 (80%) patients, the endometrial polyps showed global or partial early enhancement. On dynamic study, rapid enhancement with a persistent strong enhancement pattern was seen in 17 (42.5%) and a gradually increasing enhancement pattern was seen in 17 patients (42.5%). These MRI features can be helpful to distinguish the endometrial polyps from various other endometrial lesions. |
| キーワード | endometrial polyp central fibrous core intratumoral cyst magnetic resonance imaging (MRI) uterus |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2012-12 |
| 巻 | 66巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 475 |
| 終了ページ | 485 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2012 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23254582 |
| Web of Science KeyUT | 000312966100007 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/49723 |
| JaLCDOI | 10.18926/AMO/49043 |
|---|---|
| フルテキストURL | 66_6_469.pdf |
| 著者 | Shiozaki, Yasuyuki| Ito, Yasuo| Sugimoto, Yoshihisa| Tomioka, Masao| Shimokawa, Tetsuya| Mazaki, Tetsuro| Koshimune, Koichiro| Tanaka, Masato| Ozaki, Toshifumi| |
| 抄録 | In this study, we studied the relationship between fracture patterns and motor function recovery in 70 consecutive patients with cervical spinal cord injury. Fractures were categorized into 6 fracture types and subdivided into stages according to the Allen-Ferguson classification system:compressive flexion (CF), distractive flexion (DF), compressive extension (CE), distractive extension (DE), vertical compression (VC) and lateral flexion (LF). Paralysis was evaluated using the American Spinal Injury Association (ASIA) impairment scale at the time of injury and 3 months afterwards. The residual rate of complete motor palsy (ASIA grade A or B) at the final examination was higher in those patients with DE fractures than those with CF, DF or CE. The final outcomes were as follows. Of the 14 patients who were classified with CF fractures, residual palsy was frequently seen in patients who had stage 5 injury. Of the 27 patients with DF fractures, residual palsy occurred in about half of the patients who had stage 4 or 5 injury. Of the 18 patients with CE fractures, residual palsy occurred in half of the patients with stage 3 injury or higher. Finally, of the 7 patients with DE fractures, the rate of residual palsy was high even for the stage 1 and 2 cases;indeed, all DE patients who had complete motor palsy at the first examination had residual palsy at the final examination. Accordingly, we conclude that motor recovery may be related to fracture pattern. |
| キーワード | cervical spinal cord injury motor function recovery fracture patterns |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2012-12 |
| 巻 | 66巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 469 |
| 終了ページ | 473 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2012 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23254581 |
| Web of Science KeyUT | 000312966100006 |
| JaLCDOI | 10.18926/AMO/49042 |
|---|---|
| フルテキストURL | 66_6_461.pdf |
| 著者 | Koike, Kazuko| Takaki, Akinobu| Kato, Nobuyuki| Ouchida, Mamoru| Kanzaki, Hirotaka| Yasunaka, Tetsuya| Shiraha, Hidenori| Miyake, Yasuhiro| Yamamoto, Kazuhide| |
| 抄録 | Hepatitis C virus (HCV) infection induces several changes in hepatocytes, such as oxidative stress, steatosis, and hepatocarcinogenesis. Although considerable progress has been made during recent years, the mechanisms underlying these functions remain unclear. We employed proteomic techniques in HCV replicon-harboring cells to determine the effects of HCV replication on host-cell protein expression. We examined two-dimensional electrophoresis (2-DE) and mass spectrometry to compare and identify differentially expressed proteins between HCV subgenomic replicon-harboring cells and their “cured” cells. One of the identified proteins was confirmed using enzyme-linked immunosorbent assay (ELISA) and Western blot analysis. Full-length HCV genome RNA replicating and cured cells were also assessed using ELISA. Replicon-harboring cells showed higher expression of retinal dehydrogenase 1 (RALDH-1), which converts retinol to retinoic acid, and the cured cells showed higher expression of retinol-binding protein (RBP), which transports retinol from the liver to target tissues. The alteration in RBP expression was also confirmed by ELISA and Western blot analysis. We conclude that protein expression profiling demonstrated that HCV replicon eradication affected retinol-related protein expression. |
| キーワード | hepatitis C virus retinol-binding protein |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2012-12 |
| 巻 | 66巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 461 |
| 終了ページ | 468 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2012 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23254580 |
| Web of Science KeyUT | 000312966100005 |
| JaLCDOI | 10.18926/AMO/49041 |
|---|---|
| フルテキストURL | 66_6_449.pdf |
| 著者 | Hanayama, Yoshihisa| Uchida, Haruhito Adam| Nakamura, Yoshio| Makino, Hirofumi| |
| 抄録 | Angiotensin receptor blockers (ARBs) are the first-line antihypertensive agents. In clinical practice, it is often difficult to achieve the recommended blood pressure level by ARBs in their ordinal dosages alone. This study examined the practical efficacy of a combination therapy of ARB with thiazide diuretics for lowering morning home blood pressure (MHBP) in comparison to high-dose ARB therapy in patients with morning hypertension administered an ordinal dosage of ARB. This study was performed in a prospective, randomized, open-labeled and blind-endpoint fashion. Patients were considered to have morning hypertension when their self-measured systolic MHBPs were 135mmHg or higher, irrespective of their diastolic MHBP and office blood pressures (OBPs). Forty-eight outpatients with morning hypertension receiving the ordinal dosage of ARB were given either losartan/hydrochlorothiazide (n＝26) or high-dose ARB (n＝22) in place of their previously prescribed ARB. No change in any medication was permitted during this period. Decreases of both systolic and diastolic MHBP after 3 months of treatment were significantly greater in the losartan/hydrochlorothiazide group than in the high-dose ARB group (p＜0.05, respectively). The ratio of adverse events was somewhat high (23.1% in the losartan/hydrochlorothiazide group, 9.1% in the high-dose ARB group, respectively). However, there were no significant differences in any particular adverse event between groups. This study suggested losartan/hydrochlorothiazide might be superior to high-dose ARB for reducing morning home blood pressure. |
| キーワード | losartan hydrochlorothiazide morning blood pressure angiotensin II hyperuricemia |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2012-12 |
| 巻 | 66巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 449 |
| 終了ページ | 459 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2012 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23254579 |
| Web of Science KeyUT | 000312966100004 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/49736 |
| JaLCDOI | 10.18926/AMO/49040 |
|---|---|
| フルテキストURL | 66_6_443.pdf |
| 著者 | Ugawa, Toyomu| Sakurama, Kazufumi| Yorifuji, Takashi| Takaoka, Munenori| Fujiwara, Yasuhiro| Kabashima, Narutoshi| Azuma, Daisuke| Hirayama, Takahiro| Tsukahara, Kohei| Morisada, Sunao| Iida, Atsuyoshi| Tada, Keitaro| Shiba, Naoki| Sato, Nobuo| Ichiba, Shingo| Kino, Koichi| Fukushima, Masaki| Ujike, Yoshihito| |
| 抄録 | The functioning of an arteriovenous fistula (AVF) used for vascular access during hemodialysis has been assessed mainly by dilution methods. Although these techniques indicate the immediate recirculation rate, the results obtained may not correlate with Kt/V. In contrast, the clearance gap (CL-Gap) method provides the total recirculation rate per dialysis session and correlates well with Kt/V. We assessed the correlation between Kt/V and CL-Gap as well as the change in radial artery (RA) blood flow speed in the fistula before percutaneous transluminal angioplasty (PTA) in 45 patients undergoing continuous hemodialysis. The dialysis dose during the determination of CL-Gap was 1.2 to 1.4 Kt/V. Patients with a 10% elevation or more than a 10% relative increase in CL-Gap underwent PTA (n＝45), and the values obtained for Kt/V and CL-Gap before PTA were compared with those obtained immediately afterward. The mean RA blood flow speed improved significantly (from 52.9 to 97.5cm/sec) after PTA, as did Kt/V (1.07 to 1.30) and CL-Gap (14.1% to －0.2%). A significant correlation between these differences was apparent (r＝－0.436 and p＝0.003). These findings suggest that calculating CL-Gap may be useful for determining when PTA is required and for assessing the effectiveness of PTA, toward obtaining better dialysis. |
| キーワード | hemodialysis recirculation clearance gap vascular access percutaneous transluminal angioplasty |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2012-12 |
| 巻 | 66巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 443 |
| 終了ページ | 447 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2012 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23254578 |
| Web of Science KeyUT | 000312966100003 |
| JaLCDOI | 10.18926/AMO/49039 |
|---|---|
| フルテキストURL | 66_6_435.pdf |
| 著者 | Fujinaka, Waso| Shimizu, Juichiro| Iribe, Gentaro| Imaoka, Takeshi| Oshima, Yu| Kiyooka, Takahiko| Morita, Kiyoshi| Mohria, Satoshi| |
| 抄録 | Although propofol is commonly used for general anesthesia, its direct effects on left ventricular (LV) contractility and energetics remain unknown. Accordingly, we studied the effects of intracoronary propofol on excised cross-circulated canine hearts using the framework of the Emax (a contractility index)-PVA (systolic pressure-volume area, a measure of total mechanical energy)-Vo2 (myocardial oxygen consumption per beat) relationship. We obtained 1) the Vo2-PVA relationship of isovolumic contractions with varied LV volumes at a constant Emax, 2) the Vo2-PVA relationship with varied LV volumes at a constant intracoronary concentration of propofol, and 3) the Vo2-PVA relationship under increased intracoronary concentrations of either propofol or CaCl2 at a constant LV volume to assess the cardiac mechanoenergetic effects of propofol. We found that propofol decreased Emax dose-dependently. The slope of the linear Vo2-PVA relationship (oxygen cost of PVA) remained unchanged by propofol. The PVA-independent Vo2-Emax relationship (oxygen cost of Emax) was the same for propofol and Ca2＋. In conclusion, propofol showed a direct negative inotropic effect on LV. At its clinical concentrations, decreases in contractility by propofol were relatively small. Propofol shows mechanoenergetic effects on the LV that are similar to those of Ca2＋ blockers or ß-antagonists—i.e., it exerts negative inotropic effects without changing the oxygen costs of Emax and PVA. |
| キーワード | anesthesia heart contractility myocardial oxygen consumption |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2012-12 |
| 巻 | 66巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 435 |
| 終了ページ | 442 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2012 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23254577 |
| Web of Science KeyUT | 000312966100002 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/49732 |