検索結果 15485 件
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Zensho, Kazumasa| Miyazaki, Ikuko| Isse, Aika| Misawa, Ichika| Masai, Kaori| Oka, Makio| Tsukahara, Hirokazu| Asanuma, Masato| |
| 発行日 | 2025-02-12 |
| 出版物タイトル | Pediatric Research |
| 出版者 | Springer Science and Business Media LLC |
| ISSN | 0031-3998 |
| NCID | AA00770262 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2025 |
| 論文のバージョン | publisher |
| PubMed ID | 39939521 |
| DOI | 10.1038/s41390-025-03920-6 |
| Web of Science KeyUT | 001418931400001 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41390-025-03920-6 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Fadli, Muhammad| Hisano, Sakae| Novoa, Guy| Castón, José R.| Kondo, Hideki| Suzuki, Nobuhiro| |
| キーワード | yadokarivirus hetero-encapsidation partner dsRNA virus fungal virus Aspergillus foetidus neo-lifestyle |
| 発行日 | 2025-02-13 |
| 出版物タイトル | Journal of Virology |
| 巻 | 99巻 |
| 号 | 3号 |
| 出版者 | American Society for Microbiology |
| 開始ページ | e02166-24 |
| ISSN | 0022-538X |
| NCID | AA00708779 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2025 Fadli et al. |
| 論文のバージョン | publisher |
| PubMed ID | 39945536 |
| DOI | 10.1128/jvi.02166-24 |
| Web of Science KeyUT | 001421220200001 |
| 関連URL | isVersionOf https://doi.org/10.1128/jvi.02166-24 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Naniwa, Shuichi| Nishida, Keiichiro| Yoshida, Aki| Nasu, Yoshihisa| Nakahara, Ryuichi| Ohtsuki, Takashi| Hotta, Yoshifumi| Shimizu, Noriyuki| Ichikawa, Chinatsu| Lin, Deting| Otsuka, Noriaki| Ozaki, Toshifumi| |
| キーワード | osteoarthritis chondrocyte mechanical stress LRP4 Agrin β-catenin SOX9 |
| 発行日 | 2025-01-24 |
| 出版物タイトル | International Journal of Molecular Sciences |
| 巻 | 26巻 |
| 号 | 3号 |
| 出版者 | MDPI |
| 開始ページ | 1007 |
| ISSN | 1661-6596 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2025 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 39940775 |
| DOI | 10.3390/ijms26031007 |
| Web of Science KeyUT | 001418599900001 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijms26031007 |
| 著者 | Van, Phong Ngoc| Do, Son Quang| Fonseka, Wanniarachchige Tharindu Lakshitha| Wakai, Takuya| Funahashi, Hiroaki| |
|---|---|
| 備考 | © 2025 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Feb. 2026.| |
| 発行日 | 2025-04-01 |
| 出版物タイトル | Theriogenology |
| 巻 | 236巻 |
| 出版者 | Elsevier BV |
| 開始ページ | 74 |
| 終了ページ | 81 |
| ISSN | 0093-691X |
| NCID | AA00862972 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2025 Elsevier Inc. |
| 論文のバージョン | author |
| PubMed ID | 39922120 |
| DOI | 10.1016/j.theriogenology.2025.02.001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.theriogenology.2025.02.001 |
| 著者 | Nguyen, Hai Thanh| Do, Son Quang| Wakai, Takuya| Funahashi, Hiroaki| |
|---|---|
| キーワード | Spermatozoa Mitochondria Mitochondrial DNA Penetrability Spermatogenesis |
| 備考 | © 2024 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Dec. 2025.| |
| 発行日 | 2025-03-01 |
| 出版物タイトル | Theriogenology |
| 巻 | 234巻 |
| 出版者 | Elsevier BV |
| 開始ページ | 125 |
| 終了ページ | 132 |
| ISSN | 0093-691X |
| NCID | AA00862972 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 Elsevier Inc. |
| 論文のバージョン | author |
| PubMed ID | 39689446 |
| DOI | 10.1016/j.theriogenology.2024.12.012 |
| Web of Science KeyUT | 001413808000001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.theriogenology.2024.12.012 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Canyan, Kuang| Arias, Zulema Rosalia| Omori, Kazuhiro| Yamamoto, Tadashi| Shinoda-Ito, Yuki| Takashiba, Shogo| |
| キーワード | soybean soy products oral diseases dental application antibacterial effect antioxidant anticancer |
| 発行日 | 2025-01 |
| 出版物タイトル | International Journal of Food Science and Technology |
| 巻 | 60巻 |
| 号 | 1号 |
| 出版者 | Oxford University Press (OUP) |
| 開始ページ | vvae044 |
| ISSN | 0950-5423 |
| NCID | AA10710609 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2025. |
| 論文のバージョン | publisher |
| DOI | 10.1093/ijfood/vvae044 |
| Web of Science KeyUT | 001414446300002 |
| 関連URL | isVersionOf https://doi.org/10.1093/ijfood/vvae044 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Naing, Shine Shane| Fujioka, Haruna| Matsuura, Teruhisa| Miyatake, Takahisa| |
| キーワード | Caffeine Life span Locomotor activity Pollinator |
| 備考 | The version of record of this article, first published in Applied Entomology and Zoology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s13355-025-00893-0| |
| 発行日 | 2025-02-09 |
| 出版物タイトル | Applied Entomology and Zoology |
| 出版者 | Springer Science and Business Media LLC |
| ISSN | 0003-6862 |
| NCID | AA00543238 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2025 |
| 論文のバージョン | publisher |
| DOI | 10.1007/s13355-025-00893-0 |
| Web of Science KeyUT | 001416045200001 |
| 関連URL | isVersionOf https://doi.org/10.1007/s13355-025-00893-0 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Matsumori, Hiroaki| Dinh, Thi Quyen| Miyoshi, Shin-ichi| Morita, Masayuki| Kim, Hye-Sook| |
| キーワード | Synthetic antimalarial endoperoxide Transdermal N-89 Artemisinin In vivo Abnormal trophozoite Endoplasmic reticulum-resident calcium-binding protein (ERC) Parasite egress-related gene |
| 発行日 | 2025-06 |
| 出版物タイトル | Parasitology International |
| 巻 | 106巻 |
| 出版者 | Elsevier BV |
| 開始ページ | 103026 |
| ISSN | 1383-5769 |
| NCID | AA11112001 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2025 The Authors. |
| 論文のバージョン | publisher |
| PubMed ID | 39740755 |
| DOI | 10.1016/j.parint.2024.103026 |
| Web of Science KeyUT | 001414482100001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.parint.2024.103026 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Sato, Ryosuke| Matsumoto, Kazuyuki| Uka, Mayu| Takagi, Kosei| Nishida, Kenji| Tanaka, Takehiro| Fujii, Yuki| Tsutsumi, Koichiro| Horiguchi, Shigeru| Otsuka, Motoyuki| |
| キーワード | Pancreatic intraductal neoplasms Pancreatic carcinoma Intraductal tubulopapillary neoplasm Genetic testing |
| 備考 | The version of record of this article, first published in Clinical Journal of Gastroenterology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s12328-025-02098-y| |
| 発行日 | 2025-02-05 |
| 出版物タイトル | Clinical Journal of Gastroenterology |
| 巻 | 18巻 |
| 号 | 2号 |
| 出版者 | Springer Science and Business Media LLC |
| 開始ページ | 376 |
| 終了ページ | 382 |
| ISSN | 1865-7257 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2025 |
| 論文のバージョン | publisher |
| PubMed ID | 39910028 |
| DOI | 10.1007/s12328-025-02098-y |
| Web of Science KeyUT | 001415187700001 |
| 関連URL | isVersionOf https://doi.org/10.1007/s12328-025-02098-y |
| JaLCDOI | 10.18926/AMO/68363 |
|---|---|
| フルテキストURL | 79_1_059.pdf |
| 著者 | Minakawa, Shun| Hirano, Masayuki| Takahashi, Kazuya| Imamura, Yuta| Watanabe, Takashi| |
| 抄録 | Intraorbital arteriovenous fistulas (IOAVFs) are rare vascular abnormalities. We describe a case of an IOAVF featuring a direct shunt between the accessory meningeal artery and the superior ophthalmic artery. A 55-year-old woman presented with a 1-month history of visual impairment in her right eye, and magnetic resonance imaging (MRI) revealed optic neuritis-like findings. Steroid pulse therapy temporarily resolved visual impairment. However, 1 month later, she experienced decreased visual acuity, ocular conjunctival hyperemia, edema, and a pulsatile murmur. Contrast-enhanced MRI and digital subtraction angiography revealed compression optic neuropathy due to an IOAVF. Following successful treatment with transarterial embolization, her symptoms disappeared. |
| キーワード | intraorbital arteriovenous fistula compressive optic neuropathy accessory meningeal artery superior ophthalmic vein |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-02 |
| 巻 | 79巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 59 |
| 終了ページ | 64 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 40012161 |
| Web of Science KeyUT | 001440463800008 |
| JaLCDOI | 10.18926/AMO/68362 |
|---|---|
| フルテキストURL | 79_1_051.pdf |
| 著者 | Miura, Taro| Kawasaki, Yoichi| Hamano, Hirofumi| Zamami, Yoshito| Sendo, Toshiaki| |
| 抄録 | Photoinitiators are used in the manufacture of many daily products, and may produce harmful effects due to their cytotoxicity. They have also been detected in human serum. Here, we investigated the histamine-producing effects in HMC-1 cells and the inflammatory cytokine release effects in RAW264 cells for four photoinitiators: 1-hydroxycyclohexyl phenyl ketone; 2-isopropylthioxanthone; methyl 2-benzoylbenzoate; and 2-methyl-4´-(methylthio)-2-morpholinopropiophenone. All four promoted histamine production in HMC-1 cells; however, they did not significantly affect the release of inflammatory cytokines in RAW264 cells. These findings suggest that these four photoinitiators induce inflammatory cytokine-independent histamine production, potentially contributing to histamine-mediated chronic inflammation in vitro. |
| キーワード | photoinitiator ink injection histamine inflammation |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-02 |
| 巻 | 79巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 51 |
| 終了ページ | 58 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 40012160 |
| Web of Science KeyUT | 001440463800007 |
| JaLCDOI | 10.18926/AMO/68361 |
|---|---|
| フルテキストURL | 79_1_047.pdf |
| 著者 | Kojima, Kazunori| Ujikawa, Takuya| Ono, Toshiro| |
| 抄録 | We assessed the immediate effects of a home-based rehabilitation (HBR) program on the balance performance and toe-grip strength of 29 older adults (mean±SD age of 75.1±9.9; 16 males, 13 females) who were participating in HBR services provided by Japan’s nursing care insurance system. Their toe-grip strength and balance performance were measured before and after the HBR program. The subjects’ toe-grip strength was significantly improved after the treatment. The subjects who had had a stroke showed a significant improvement after HBR. Contrarily, no significant difference was observed in the subjects’ functional reach results or their one-leg standing time. These results indicate that the exercise regimen provided in the HBR program led to increased excitability of motor units and immediately enhanced the subjects’ toe-grip strength. |
| キーワード | home-based rehabilitation toe-grip strength balance performance |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-02 |
| 巻 | 79巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 47 |
| 終了ページ | 50 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 40012159 |
| Web of Science KeyUT | 001440463800006 |
| レファレンス | Kira K: The basic approach to determining the effects of cerebrovascular disease and in the maintenance phase of rehabilitation. Phys Ther Jpn (2011) 38: 246-248 (in Japanese).| Ito T: Role of physical therapists at the home health care. Phys Ther Jpn (2001) 28: 399-402 (in Japanese).| Kojima K, Nakayama T, Watanabe A, Yoshimura S, Yamaya T, Sato K, Doi A, Ogino T, Moriyasu N and Watanabe S: Activities of daily living and quality of life assessment during home-based rehabilitation. Jpn J Compr Rehabil Sci (2017) 8: 30-36.| Benvenuti F, Ferrucci L, Guralnik JM, Gangemi S and Baroni A: Foot pain and disability in older persons: an epidemiologic survey. J Am Geriatr Soc (1995) 43: 479-484.| Kojima K, Kamai D, Yamamoto A, Tsuchitani Y and Kataoka H: The Effect of toe-grasping exercises on balance ability in home-based rehabilitation: a randomized controlled trial by block randomization. Phys Ther Res (2021) 24: 272-279.| Elm E von, Altman DG, Egger M, Pocock SJ, Gøtzsche PC and Vandenbroucke JP: The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Int J Surg (2014) 12: 1495-1499.| Uritani D, Fukumoto T and Matsumoto D: Intrarater and interrater reliabilities for a toe grip dynamometer. J Phys Ther Sci (2012) 24: 639-643.| Vellas BJ, Wayne SJ, Romero L, Baumgartner RN, Rubenstein LZ and Garry PJ: One-Leg Balance Is an important predictor of injurious falls in older persons. J Am Geriatr Soc (1997) 45: 735-738.| Duncan PW, Weiner DK, Chandler J and Studenski S: Functional Reach: A new clinical measure of balance. J Gerontol (1990) 45: M192-197.| Sale DG: Postactivation Potentiation: Role in human performance. Exer Sport Sci Rev (2002) 30: 138-143.| Gossen ER and Sale DG: Effect of postactivation potentiation on dynamic knee extension performance. Eur J Appl Physiol (2000) 83: 524-530.| Jones DA, Newham DJ and Torgan C: Mechanical influences on long-lasting human muscle fatigue and delayed-onset pain. J Physiol (1989) 412: 415-427.| Eston RG, Finney S, Baker S and Baltzopoulos V: Muscle tenderness and peak torque changes after downhill running following a prior bout of isokinetic eccentric exercise. J Sports Sci (1996) 14: 291-299.| Onuma R, Soutome Y, Asada Y, Kurihara Y, Fujino Y and Matsuda T: Immediate effect of exercise therapy using ʼspiderʼ for chronic stroke patients with hemiplegia. Rigakuryoho Kagaku (2020) 35: 791-795 (in Japanese).| |
| JaLCDOI | 10.18926/AMO/68360 |
|---|---|
| フルテキストURL | 79_1_039.pdf |
| 著者 | Takao, Shinichiro| Uotani, Koji| Misawa, Haruo| Tetsunaga, Tomoko| Shinohara, Kensuke| Yamane, Kentaro| Oda, Yoshiaki| Tsuji, Hironori| Kajiki, Yuya| Ozaki, Toshifumi| |
| 抄録 | Evaluating vertebral bone mass and quality in the elderly poses challenges due to degenerative changes. This study aims to elucidate the usefulness of the trabecular bone score (TBS) by examining the relationship between bone mineral density (BMD), TBS, and Hounsfield unit (HU) values. A retrospective analysis of 599 vertebrae from 152 patients (mean age 69.0 years; range 44-89; 74 males and 78 females) undergoing dual-energy X-ray absorptiometry (DXA) and CT scans was conducted. Vertebrae were categorized into three grades based on the degree of degeneration. The TBS was calculated from DXA images, and the HU value was measured by placing a region of interest on an axial image of the vertebral mid-body. One-way analysis of variance and Pearson’s correlation tests were employed to investigate the relationship between BMD and TBS or HU values. While lumbar BMD significantly increased (p<0.01) with degenerative changes, TBS and HU values showed no significant differences. The correlations between lumbar BMD and TBS values, and between BMD and HU values, were stronger without degenerative changes than with degenerative changes. Significantly different HU values were observed between the right and left sides of severely degenerated vertebrae. Severe degenerative changes, particularly those associated with sclerosis, may impact HU values. TBS exhibits greater potential than HU values as a complementary tool. |
| キーワード | trabecular bone score computed tomography Hounsfield unit lumbar degenerative change radiodensity |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-02 |
| 巻 | 79巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 39 |
| 終了ページ | 45 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 40012158 |
| Web of Science KeyUT | 001440463800005 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Ueda, Ayaka| Shinoda-Ito, Yuki| Takeuchi-Hatanaka, Kazu| Ito, Takashi| Ono, Shintaro| Hirai, Kimito| Omori, Kazuhiro| Yamamoto, Tadashi| Takashiba, Shogo| |
| キーワード | Dental education Infection control Fluorescent dye Adenosine triphosphate Lactobacillus |
| 発行日 | 2025-02-08 |
| 出版物タイトル | BMC Oral Health |
| 巻 | 25巻 |
| 号 | 1号 |
| 出版者 | BMC |
| 開始ページ | 199 |
| ISSN | 1472-6831 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2025. |
| 論文のバージョン | publisher |
| PubMed ID | 39923078 |
| DOI | 10.1186/s12903-025-05584-4 |
| Web of Science KeyUT | 001416641300005 |
| 関連URL | isVersionOf https://doi.org/10.1186/s12903-025-05584-4 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Ooba, Hikaru| Maki, Jota| Masuyama, Hisashi| |
| キーワード | Perinatal mental disorders Voice analysis Machine learning Screening Pregnant women |
| 発行日 | 2025-02-08 |
| 出版物タイトル | Discover Mental Health |
| 巻 | 5巻 |
| 号 | 1号 |
| 出版者 | Springer Nature |
| 開始ページ | 12 |
| ISSN | 2731-4383 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2025 |
| 論文のバージョン | publisher |
| PubMed ID | 39920468 |
| DOI | 10.1007/s44192-025-00138-0 |
| Web of Science KeyUT | 001415532800001 |
| 関連URL | isVersionOf https://doi.org/10.1007/s44192-025-00138-0 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Yagi, Tomohiko| Kagawa, Shunsuke| Nogi, Shohei| Taniguchi, Atsuki| Yoshimoto, Masashi| Suemori, Kanto| Nagai, Yasuo| Fujita, Shuto| Kuroda, Shinji| Kikuchi, Satoru| Kakiuchi, Yoshihiko| Teraishi, Fuminori| Takagi, Kosei| Ohara, Toshiaki| Tazawa, Hiroshi| Fujiwara, Toshiyoshi| |
| キーワード | Cancer-associated fibroblasts Neutrophil Anti-fibrotic agent Pirfenidone |
| 発行日 | 2025-02-04 |
| 出版物タイトル | Cancer Immunology, Immunotherapy |
| 巻 | 74巻 |
| 号 | 3号 |
| 出版者 | Springer |
| 開始ページ | 96 |
| ISSN | 0340-7004 |
| NCID | AA00598499 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2025 |
| 論文のバージョン | publisher |
| PubMed ID | 39904796 |
| DOI | 10.1007/s00262-025-03946-z |
| Web of Science KeyUT | 001413348800005 |
| 関連URL | isVersionOf https://doi.org/10.1007/s00262-025-03946-z |
| JaLCDOI | 10.18926/AMO/68356 |
|---|---|
| フルテキストURL | 79_1_031.pdf |
| 著者 | Maeda, Shigeru| Pimkhaokham, Atiphan| Yoshida, Michihiro| Hosoi, Hiroki| Ohshima, Ayako| Kurisu, Ryoko| Utsumi, Nozomi| Higuchi, Hitoshi| Miyawaki, Takuya| |
| 抄録 | We retrospectively analyzed the safety of the use of articaine, an amide-type local anesthetic, in Japanese dental patients (n=300) treated in Thailand in 2015-2017. The dosage, adverse events (AEs) caused by local anesthesia, and treatment efficacy were examined. Articaine, which is safe for patients with liver impairments due to its unique metabolism, has not been thoroughly tested in Japan for doses above 5.1 mL. Eighty of the present patients had undergone root canal treatment (RCT), 71 underwent tooth extraction, and 149 underwent implant-related surgery. More than three articaine cartridges were used in 41 patients, and no AEs occurred in these cases. The only AE occurred in a 52-year-old woman who was treated with three cartridges and presented with what appeared to be hyperventilation syndrome; she later recovered and received her dental treatment as scheduled. Most treatments were completed with three or fewer cartridges, suggesting that this number is generally sufficient. Our findings, particularly the low AE risk even with doses exceeding three cartridges, support the potential applicability of the overseas recommended maximum dose of articaine (7 mg/kg) in Japanese patients. This conclusion is significant for advancing dental anesthetic practices and ensuring patient safety and treatment efficacy in Japan. |
| キーワード | dental anesthesia local anesthesia drug-related side effect adverse reaction |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-02 |
| 巻 | 79巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 31 |
| 終了ページ | 37 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 40012157 |
| Web of Science KeyUT | 001440463800004 |
| JaLCDOI | 10.18926/AMO/68355 |
|---|---|
| フルテキストURL | 79_1_021.pdf |
| 著者 | Yamamoto, Yasuhiro| Haraguchi, Takafumi| Matsuda, Kaori| Okazaki, Yoshio| Kimoto, Shin| Tanji, Nozomu| Matsumoto, Atsushi| Kobayashi, Yasuyuki| Mimura, Hidefumi| Hiraki, Takao| |
| 抄録 | We developed a machine learning model for predicting prostate cancer (PCa) grades using radiomic features of magnetic resonance imaging. 112 patients diagnosed with PCa based on prostate biopsy between January 2014 and December 2021 were evaluated. Logistic regression was used to construct two prediction models, one using radiomic features and prostate-specific antigen (PSA) values (Radiomics model) and the other Prostate Imaging-Reporting and Data System (PI-RADS) scores and PSA values (PI-RADS model), to differentiate high-grade (Gleason score [GS] ≥ 8) from intermediate or low-grade (GS < 8) PCa. Five imaging features were selected for the Radiomics model using the Gini coefficient. Model performance was evaluated using AUC, sensitivity, and specificity. The models were compared by leave-one-out cross-validation with Ridge regularization. Furthermore, the Radiomics model was evaluated using the holdout method and represented by a nomogram. The AUC of the Radiomics and PI-RADS models differed significantly (0.799, 95% CI: 0.712-0.869; and 0.710, 95% CI: 0.617-0.792, respectively). Using holdout method, the Radiomics model yielded AUC of 0.778 (95% CI: 0.552-0.925), sensitivity of 0.769, and specificity of 0.778. It outperformed the PI-RADS model and could be useful in predicting PCa grades, potentially aiding in determining appropriate treatment approaches in PCa patients. |
| キーワード | prostate cancer machine learning prostate Imaging-Reporting and Data System radiomics Gleason score |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-02 |
| 巻 | 79巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 21 |
| 終了ページ | 30 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 40012156 |
| Web of Science KeyUT | 001440463800003 |
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| JaLCDOI | 10.18926/AMO/68354 |
|---|---|
| フルテキストURL | 79_1_009.pdf |
| 著者 | Ikeya, Nanami| Okita, Atsushi| Hashida, Shinsuke| Yamamoto, Sumiharu| Ikeda, Hirokuni| Tsukuda, Kazunori| Toyooka, Shinichi| |
| 抄録 | Muscle loss negatively affects gastrectomy prognosis. However, muscle loss is recognized as a systemic change, and individual muscle function is often overlooked. We investigated changes in the muscle volume of individual muscles after gastrectomy to identify clues for prognostic factors and optimal rehabilitation programs. Patients who underwent R0 gastrectomy for Stage I gastric cancer at our hospital from 2015 to 2021 were retrospectively selected to minimize the effects of malignancy and chemotherapy. Trunk muscle volume was measured by computed tomography to analyze body composition changes. Statistical analysis was performed to identify risk factors related to body composition changes. We compared the preoperative and 6-month postoperative conditions of 59 patients after gastrectomy. There was no difference in the psoas major muscle, a conventional surrogate marker of sarcopenia. There were significant decreases in the erector spinae (p=0.01) and lateral abdominal (p=0.01) muscles, and a significant increase in the rectus abdominis muscle (p=0.02). No significant correlation was found between these muscle changes and nutritional status. Body composition imbalance may serve as a new indicator of the general condition of patients after gastrectomy. Rehabilitation to correct this imbalance may improve prognosis after gastrectomy. |
| キーワード | sarcopenia skeletal muscle gastric cancer gastrectomy erector spinae muscle |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-02 |
| 巻 | 79巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 9 |
| 終了ページ | 19 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 40012155 |
| Web of Science KeyUT | 001440463800002 |
| JaLCDOI | 10.18926/AMO/68353 |
|---|---|
| フルテキストURL | 79_1_001.pdf |
| 著者 | Thiha, Moe| Hikita, Takao| Nakayama, Masanori| |
| 抄録 | Endothelial cell polarity is fundamental to the organization and function of blood vessels, influencing processes such as angiogenesis, vascular stability, and response to shear stress. This review elaborates on the molecular mechanisms that regulate endothelial cell polarity, focusing on key players like the PAR polarity complex and Rho family GTPases. These pathways coordinate the front–rear, apical–basal and planar polarity of endothelial cells, which are essential for the proper formation and maintenance of vascular structures. In health, endothelial polarity ensures not only the orderly development of blood vessels, with tip cells adopting distinct polarities during angiogenesis, but also ensures proper vascular integrity and function. In disease states, however, disruptions in polarity contribute to pathologies such as coronary artery disease, where altered planar polarity exacerbates atherosclerosis, and cancer, where disrupted polarity in tumor vasculature leads to abnormal vessel growth and function. Understanding cell polarity and its disruption is fundamental not only to comprehending how cells interact with their microenvironment and organize themselves into complex, organ-specific tissues but also to developing novel, targeted, and therapeutic strategies for a range of diseases, from cardiovascular disorders to malignancies, ultimately improving patient outcomes. |
| キーワード | blood vessel endothelial cell cell polarity atherosclerosis cancer |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2025-02 |
| 巻 | 79巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 1 |
| 終了ページ | 7 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2025 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 40012154 |
| Web of Science KeyUT | 001440463800001 |