検索結果 278 件
| JaLCDOI | 10.18926/AMO/56867 |
|---|---|
| フルテキストURL | 73_3_241.pdf |
| 著者 | Utsumi, Masashi| Aoki, Hideki| Nishimura, Seitaro| Une, Yuta| Kashima, Hajime| Kimura, Yuji| Taniguchi, Fumitaka| Arata, Takashi| Katsuda, Koh| Tanakaya, Kohji| |
| 抄録 | Gallbladder carcinoma (GBC) is a common malignancy with a poor prognosis. With the average life expectancy increasing globally, the incidence of GBC is predicted to increase as well. We investigated the safety and feasibility of surgical treatment for elderly patients with GBC. We retrospectively compared clinical pathological data and treatment outcomes in 45 consecutive GBC patients (23 patients ≥ 75 years [elderly group] and 22 patients < 75 years [younger group]) who underwent curative resection at the Iwakuni Center from January 2008 to December 2017. The proportion of preoperative comorbidities and anticoagulant use was significantly higher in the elderly group. The American Society of Anesthesiologists score was higher in the elderly versus the younger group, and the elderly group had significantly shorter operation times. Reduced activities of daily living was more common in the elderly versus younger group. The percentage of radical resection and overall 3-year survival (66.6% younger vs. 64.4% elderly) were similar between the groups. Controlling Nutritional Status (CONUT) score ≥ 3 and R0 resection were identified as prognostic factors for overall survival rate among all patients. After careful patient selection, |
| キーワード | elderly patient gallbladder carcinoma prognostic factor surgical treatment |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-06 |
| 巻 | 73巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 241 |
| 終了ページ | 246 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31235972 |
| JaLCDOI | 10.18926/AMO/56864 |
|---|---|
| フルテキストURL | 73_3_223.pdf |
| 著者 | Sugiu, Kazuhisa| Furumatsu, Takayuki| Kodama, Yuya| Kamatsuki, Yusuke| Okazaki, Yoshiki| Okazaki, Yuki| Hiranaka, Takaaki| Ozaki, Toshifumi| |
| 抄録 | Anterior cruciate ligament (ACL) reconstruction (ACLR) after ACL rupture improves the instability of the knee joint and decreases mechanical stress to the meniscus and articular cartilage. However, there are reports that post-traumatic osteoarthritis (PTOA) is observed over time following ACLR. In this study, we assessed changes in cartilage lesions by arthroscopic findings following anatomical double-bundle ACLR and at post-operative second-look arthroscopy about 14 months later. We retrospectively evaluated 37 knees in cases with patients <40 years of age who had undergone an anatomical double-bundle ACL reconstruction <1 year after ACL rupture injury from March 2012 to December 2016. Clinical results and arthroscopic cartilage/meniscal lesion were evaluated and compared between a cartilage lesion-detected group and intact-cartilage group. Surgery improved anteroposterior laxity and other clinical measures; however, cartilage lesions were detected at 11 sites during ACLR and at 54 sites at second-look arthroscopy. The periods from injury to second-look arthroscopy and from ACLR to second-look arthroscopy were significantly longer in the cartilage-lesion group (n=23) than in the intact-cartilage group (n=14). Conversely, 96% of meniscal damage observed during ACLR was cured at the time of second-look arthroscopy. Knee articular cartilage lesions after ACL rupture cannot be completely suppressed, even using the anatomical ACL reconstruction technique. This study suggested that articular cartilage lesions can progress to a level that can be confirmed arthroscopically at approximately 17 months after ACL injury. Therefore, in ACLR patients, the possibility of developing knee articular cartilage lesions and PTOA should be considered. |
| キーワード | anterior cruciate ligament reconstruction post-traumatic osteoarthritis meniscal lesion cartilage lesions second-look arthroscopy |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-06 |
| 巻 | 73巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 223 |
| 終了ページ | 228 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31235969 |
| JaLCDOI | 10.18926/AMO/56861 |
|---|---|
| フルテキストURL | 73_3_197.pdf |
| 著者 | Nishimura, Takeshi| Naito, Hiromichi| Matsuyama, Shigenari| Ishihara, Satoshi| Nakao, Atsunori| Nakayama, Shinichi| |
| 抄録 | Japan's population has been skewing toward the elderly, but the outcomes of advanced elderly trauma are not clear. Here we compared the outcomes of very elderly trauma patients (≧85 years old) with those of 65- to 84-year-old trauma patients. We retrospectively reviewed the medical records of patients treated at Hyogo Emergency Medical Center from August 2010 to August 2016; 631 patients were entered in the study. We divided them into the younger geriatrics (YG group, 65-84 years old: n=534) and older geriatrics (OG group, ≧85 years old: n=97). The group’s patient characteristics, mortality, 1-year survival rate, and Barthel index were tabulated and compared. The patients’ mean age was 75.6±7.5 years. There was no significant difference in mortality between the YG and OG groups (9.6% vs. 15.1%, odds ratio [OR] 1.73; 95% confidence interval [CI] 0.93-3.23, p=0.083). The 1-year survival rate (94.4% vs. 77.8%, OR 0.19, 95% CI 0.07-0.51; p<0.01) and Barthel index (Median score; 100 (IQR: 85-100) vs. 80 (IQR: 15-95), OR 0.98, 95% CI 0.97 to 0.99, p<0.01) differed significantly between the groups. Our study did not find a significant difference in-hospital mortality between patients in the YG group and those in the OG group. |
| キーワード | aged injury mortality morbidity trauma |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-06 |
| 巻 | 73巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 197 |
| 終了ページ | 203 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31235966 |
| JaLCDOI | 10.18926/AMO/56860 |
|---|---|
| フルテキストURL | 73_3_189.pdf |
| 著者 | Sakamoto, Shinji| Kawai, Hiroki| Okahisa, Yuko| Tsutsui, Ko| Kanbayashi, Takashi| Tanaka, Keiko| Mizuki, Yutaka| Takaki, Manabu| Yamada, Norihito| |
| 抄録 | Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a recently-discovered autoimmune disorder in which antibodies target NMDAR in the brain. The number of reported cases of anti-NMDAR encephalitis has increased rapidly. Anti-NMDAR encephalitis can be mistakenly diagnosed as psychiatric disorders because many patients present with prominent psychiatric symptoms and visit psychiatric institutions first. Thus, psychiatrists should cultivate a better understanding of anti-NMDAR encephalitis. In this review, we present the mechanisms, epidemiology, symptoms and clinical course, diagnostic tests, treatment and outcomes of patients with anti-NMDAR encephalitis. Furthermore, we discuss the diversity of clinical spectra of anti-NMDAR encephalitis, and demonstrate a differential diagnosis of psychiatric disease from the perspective of psychiatry. |
| キーワード | NMDAR encephalitis psychiatric symptom schizophrenia mood disorder |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-06 |
| 巻 | 73巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 189 |
| 終了ページ | 195 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31235965 |
| JaLCDOI | 10.18926/AMO/56648 |
|---|---|
| フルテキストURL | 73_2_127.pdf |
| 著者 | Iwasaki, Yukari| Miyahara, Kimiko| Miyatake, Nobuyuki| Nakatsuka, Mikiya| |
| 抄録 | We aimed to clarify the state of thyroid function in female high school long-distance runners. We evaluated the associations between thyroid function and menstrual condition, bone mineral density (BMD), nutritious status, and body composition. The subjects’ height and weight were measured, along with fat percentage, fat mass, muscle mass, and BMD with dual-energy X-ray absorptiometry. A nutrition and dietary survey measured the subjects’ intake of energy and nutrients based on meals provided at the subjects’ dorm for 3 days in July of 2016 and 2017. Blood parameters including thyroid hormone and estradiol were measured. Most of the subjects (81.3%) were underweight (body mass index <18.5). The thyroid hormone free T3 value was decreased, but TSH was not increased and was similar to that observed in individuals with anorexia nervosa. In our subjects, thyroid hormone was associated with BMD and nutritional intake. To improve the menstruation abnormality of female athletes and to increase their bone density, the athletes’ weight should be managed by proper nutrient intake and the maintenance of their thyroid function. |
| キーワード | thyroid function nutritious status female high school long-distance runners bone mineral density menstrual condition |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-04 |
| 巻 | 73巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 127 |
| 終了ページ | 133 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 31015747 |
| JaLCDOI | 10.18926/AMO/56462 |
|---|---|
| フルテキストURL | 73_1_77.pdf |
| 著者 | Morita, Mio| Matsumoto, Hiroshi| Shirakawa, Yasuhiro| Noma, Kazuhiro| Tanabe, Shunsuke| Kimata, Yoshihiro| |
| 抄録 | Anterior cervical plate fixation is a common surgical treatment for cervical spine trauma, disc herniation, or cervical spondylosis. Esophageal perforation following anterior cervical plate fixation is a rare but serious complication. Management of esophageal perforation is controversial; however, we suggest treating most cases surgically because this condition is slow to heal and often fatal. We managed 2 cases of esophageal perforation following anterior cervical plate fixation by flap reconstruction with the pectoralis major muscle in one case and a jejunal free flap in the other. Here, we report our experience and review the surgical indications. |
| キーワード | anterior cervical plate fixation esophageal perforation reconstruction pectoralis major flap jejunal free flap |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-02 |
| 巻 | 73巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 77 |
| 終了ページ | 80 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 30820058 |
| JaLCDOI | 10.18926/AMO/56456 |
|---|---|
| フルテキストURL | 73_1_29.pdf |
| 著者 | Matsumoto, Atsushi| Nakamura, Takehiro| Shinomiya, Aya| Kawakita, Kenya| Kawanishi, Masahiko| Miyake, Keisuke| Kuroda, Yasuhiro| Keep, Richard F.| Tamiya, Takashi| |
| 抄録 | Cerebral vasospasm (CVS) is a major contributor to the high morbidity and mortality of aneurysmal subarachnoid hemorrhage (aSAH) patients. We measured histidine-rich glycoprotein (HRG), a new biomarker of aSAH, in cerebrospinal fluid (CSF) to investigate whether HRG might be an early predictor of CVS. A total of seven controls and 14 aSAH patients (8 males, 6 females aged 53.4±15.4 years) were enrolled, and serial CSF and serum samples were taken. We allocated these samples to three phases (T1-T3) and measured HRG, interleukin (IL)-6, fibrinopeptide A (FpA), and 8-hydroxy-2’-deoxyguanosine (8OHdG) in the CSF, and the HRG in serum. We also examined the release of HRG in rat blood incubated in artificial CSF. In contrast to the other biomarkers examined, the change in the CSF HRG concentration was significantly different between the nonspasm and spasm groups (p<0.01). The rat blood/CSF model revealed a time course similar to that of the human CSF samples in the non-spasm group. HRG thus appears to have the potential to become an early predictor of CVS. In addition, the interaction of HRG with IL-6, FpA, and 8OHdG may form the pathology of CVS. |
| キーワード | biomarker histidine-rich glycoprotein predictor subarachnoid hemorrhage vasospasm |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-02 |
| 巻 | 73巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 29 |
| 終了ページ | 39 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 30820052 |
| JaLCDOI | 10.18926/AMO/56452 |
|---|---|
| フルテキストURL | 73_1_1.pdf |
| 著者 | Morizane, Shin| |
| 抄録 | Excessive protease activity is a characteristic abnormality that affects the epidermal barrier in patients with atopic dermatitis (AD). Kallikrein-related peptidases (KLKs) are excessively expressed in AD lesions, and it is suggested that the abnormal action of KLKs is involved in the skin barrier dysfunction in AD. In other words, overexpressed KLKs disrupt the normal barrier function, and due to that breakdown, external substances that can become antigens of AD easily invade the epidermis, resulting in dermatitis, coupled with the induction of Th2 cytokines. Further investigations are required to elucidate the role of KLKs in AD; this knowledge could contribute to the design of new therapeutic and prophylactic drugs for AD. |
| キーワード | atopic dermatitis kallikrein-related peptidases epidermal barrier dysfunction |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2019-02 |
| 巻 | 73巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 1 |
| 終了ページ | 6 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2019 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 30820048 |
| JaLCDOI | 10.18926/AMO/56372 |
|---|---|
| フルテキストURL | 72_6_553.pdf |
| 著者 | Omura, Daisuke| Sato, Asuka| Oka, Kosuke| Hanayama, Yoshihisa| Ogawa, Hiroko| Obika, Mikako| Otsuka, Fumio| |
| 抄録 | To clarify potential relationships between chief complaints of patients and laboratory data with a focus on aging-related changes, we retrospectively analyzed the data of 843 patients who visited a general medicine department for the first time. Their chief complaints were classified into 8 major symptoms: visceral pain, somatic pain, fever, cough, dizziness, fatigue, appetite loss, and edema. We compared the laboratory data obtained from the patients with complaints with the data of symptom-free (control) patients. The serum sodium and potassium levels in the fever group were decreased compared to those in the control group. In the fever group, the serum sodium level was inversely correlated with age. The ratio of serum urea nitrogen to creatinine (UN/Cr) was increased in the appetite-loss group. There were significant age-dependent increases in the UN/Cr ratio in the appetite-loss and edema groups. Of note, serum levels of free thyroxin were lower in the dizziness group compared to the control group. In addition, the free thyroxin level was inversely correlated with age in the dizziness group but not in the asymptomatic control group. Collectively, the results indicated that osmolality-related laboratory data are strongly associated with individual primary symptoms at the first visit regardless of the final diagnosis. The consideration of age-dependent changes of these markers is helpful for diagnosing latent disorders based on various primary symptoms. |
| キーワード | dizziness fever osmolality serum sodium thyroid dysfunction |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-12 |
| 巻 | 72巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 553 |
| 終了ページ | 562 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 30573909 |
| NAID | 120006545157 |
| フルテキストURL | PhysRevA_81_063623.pdf |
|---|---|
| 著者 | Huhtamaki, J. A. M.| Takahashi, M.| Simula, T. P.| Mizushima, T.| Machida, K.| |
| 備考 | This is an article published by American Physical Society| |
| 発行日 | 2010-06-14 |
| 出版物タイトル | Physical Review A |
| 巻 | 81巻 |
| 号 | 6号 |
| 出版者 | American Physical Society |
| 開始ページ | 063623 |
| ISSN | 24699926 |
| NCID | AA10764867 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | publisher |
| DOI | 10.1103/PhysRevA.81.063623 |
| Web of Science KeyUT | 000278719500005 |
| 関連URL | isVersionOf https://doi.org/10.1103/PhysRevA.81.063623 |
| JaLCDOI | 10.18926/AMO/54981 |
|---|---|
| フルテキストURL | 71_2_127.pdf |
| 著者 | Shirakawa, Yasuhiro| Noma, Kazuhiro| Maeda, Naoaki| Tanabe, Shunsuke| Kuroda, Shinji| Kagawa, Shunsuke| Katsui, Kuniaki| Katayama, Norihisa| Kanazawa, Susumu| Fujiwara, Toshiyoshi| |
| 抄録 | Currently, chemoradiation is the most widely used nonsurgical treatment for esophageal cancer. However, some patients, particularly the very elderly or those with severe vital organ dysfunction, face difficulty with the chemotherapy component. We therefore examined the outcome of radiation therapy (RT) alone for patients with esophageal cancer at our facility. Between January 2005 and December 2014, 84 patients underwent RT at our hospital, and 78 of these patients received concomitant chemotherapy. The remaining 6 patients underwent RT alone; these patients were considered to be high-risk and to have no lymph node metastasis (stage I). Five of them received irradiation up to a curative dose: 4 showed a complete response (CR) and 1 showed a partial response (PR). Of the patients exhibiting CR, 3 are currently living recurrence-free, whereas 1 patient underwent endoscopic submucosal dissection (ESD) as salvage therapy for local recurrence, with no subsequent recurrence. High-risk stage I esophageal cancer patients can be treated radically with RT alone under certain conditions. In the future, to broaden the indications for RT monotherapy to include some degree of advanced cancers, a novel concurrent therapy should be identified. |
| キーワード | esophageal cancer radiation therapy high-risk patient |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-04 |
| 巻 | 71巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 127 |
| 終了ページ | 133 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28420894 |
| JaLCDOI | 10.18926/AMO/54805 |
|---|---|
| フルテキストURL | 70_6_435.pdf |
| 著者 | Yamashita, Miho| Hasegawa, Kosei| Higuchi, Yousuke| Miyai, Takayuki| Okada, Ayumi| Tanaka, Hiroyuki| Tsukahara, Hirokazu| |
| 抄録 | The urinary cross-linked N-terminal telopeptide of type I collagen (uNTx) levels in infantile osteogenesis imperfecta (OI) have not been well studied. Here we investigated the levels of uNTx in infants with OI and healthy infants. We collected spot urine samples from 30 infants with OI (male/female, 14/16; Sillence classification, I/II/III/IV: 15/3/6/6; age, 5.2±4.4 months) and 120 healthy infants (male/female, 75/45; age, 5.1±4.1 months) for the measurement of uNTx levels. The uNTx levels of the OI infants were significantly lower than those of the healthy infants (mean±SD, 1,363.7±530.1 vs. 2,622.2±1,202.6 nmol BCE/mmol Cr; p＜0.001). The uNTx levels of the infants with type I OI were significantly lower than those of the age-matched healthy infants, although an overlap was observed between the 2 groups. Among the 1-month-old infants, the uNTx levels of the infants with types I, III or IV OI were significantly lower than those of the healthy infants, without overlap (1,622.5±235.8 vs. 3,781.0±1,027.1 nmol BCE/mmol Cr; p＜0.001). These results indicate that uNTx levels are significantly lower in infants with OI than in healthy infants, and they suggest that uNTx might be useful as a reference for diagnosing OI. |
| キーワード | bone resorption marker bone turnover bone mass |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2016-12 |
| 巻 | 70巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 435 |
| 終了ページ | 439 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2016 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28003667 |
| 著者 | 岩室 雅也| 岡田 裕之| 原田 馨太| 神崎 洋光| 堀 圭介| 喜多 雅英| 川野 誠司| 河原 祥朗| 田中 健大| 山本 和秀| |
|---|---|
| 発行日 | 2016-12-01 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 128巻 |
| 号 | 3号 |
| 資料タイプ | 学術雑誌論文 |
| タイトル（別表記） | Identification of the adipokine ‘vaspin’ and its significance in metabolic syndrome |
|---|---|
| フルテキストURL | 128_103.pdf |
| 著者 | 和田 淳| |
| キーワード | metabolic syndrome adipokine atherosclerosis endothelial cells apoptosis |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2016-08-01 |
| 巻 | 128巻 |
| 号 | 2号 |
| 開始ページ | 103 |
| 終了ページ | 109 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.128.103 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2016 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.128.103 |
| NAID | 130005262534 |
| タイトル（別表記） | Basic and clinical research regarding vascular endothelial function |
|---|---|
| フルテキストURL | 127_187.pdf |
| 著者 | 塚原 宏一| |
| キーワード | アルギニン代謝 一酸化窒素 ガス生物学 血管内皮学 酸化ストレス |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2015-12-01 |
| 巻 | 127巻 |
| 号 | 3号 |
| 開始ページ | 187 |
| 終了ページ | 195 |
| ISSN | 0030-1558 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2015 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.127.187 |
| NAID | 130005116819 |
| タイトル（別表記） | Role of COLXV/XVⅢ gene, Multiplexin, as a basement membrane toolkit |
|---|---|
| フルテキストURL | 127_103.pdf |
| 著者 | 大橋 俊孝| |
| キーワード | 基底膜 ツールキット XV/XVⅢ型コラーゲン プロテオグリカン ミトコンドリア |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2015-08-03 |
| 巻 | 127巻 |
| 号 | 2号 |
| 開始ページ | 103 |
| 終了ページ | 109 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.127.103 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2015 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.127.103 |
| NAID | 130005096251 |
| タイトル（別表記） | PD-1,CTLA-4 |
|---|---|
| フルテキストURL | 127_63.pdf |
| 著者 | 榮川 伸吾| |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2015-04-01 |
| 巻 | 127巻 |
| 号 | 1号 |
| 開始ページ | 63 |
| 終了ページ | 65 |
| ISSN | 0030-1558 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2015 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.127.63 |
| NAID | 130005068337 |
| JaLCDOI | 10.18926/bgeou/52429 |
|---|---|
| タイトル（別表記） | Proton Magnetic Resonance Spectroscopy in Patients with Migration Disorders |
| フルテキストURL | 110_0029_0034.pdf |
| 著者 | 眞田 敏| 浅野 孝| 岡 鍈次| 河原 道子| 栄 勝美| 平木 祥夫| 大田原 俊輔| |
| 抄録 | Proton Magnetic Resonance Spectroscopy (1H-MRS) can be used to detect cerebral metabolites including N-acetylaspartate (NAA)，creatine (Cr) and choline (Ch). Hence，clinical applications of this method for neuropediatric diseases can be expected. However，regarding neuronal migration disorders，there have been only a few reported studies. We therefore examined the lH-MRS in six patients with migration disorders，ages ranged from 8months to 28years 10months with a mean of 10years 10months. Investigation was performed using Magnetom H15 (Siemens) with a repetition time of 1500 msec and an echo time of 270msec. The ratio of NAA/Cr，Ch/Cr were examined. The volume of interest with the size of 2 × 2 × 2 ～ 3 × 3 × 5cm3 was chosen in the area including lesions，and a contralateral area without lesions was also investigated. Results were as follows. 1) The ratio of NAA/Cr was low in the area with lesions in all 6cases; 1.41，1.95，2.27 and 1.71 in cases with heterotopic gray matter，0.99 in one case with polymicrogyria，an d 1.30 in one case with hemimegalencephaly，contrasted with a contralataral area without lesions: 1.89， 2.89，2.87，2.55，3.26，2.03，respectively. 2) The ratio of Ch/Cr showed no consistent difference between the area including lesions and contralataral area without lesions. Our findings of a decreased NAA/Cr ratio can be inferred to reflect the decreased numbers of neuronal cell population，or reduced metabolism in the lesions. |
| キーワード | MR spectroscopy migration disorder heterotopic gray matter polymicrogyria hemimegalencephaly |
| 出版物タイトル | 岡山大学教育学部研究集録 |
| 発行日 | 1999-03-15 |
| 巻 | 110巻 |
| 開始ページ | 29 |
| 終了ページ | 34 |
| ISSN | 0471-4008 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120005425646 |
| 著者 | 晴田 佑介| 河崎 陽一| 北村 佳久| 千堂 年昭| |
|---|---|
| 発行日 | 2013-12-02 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 125巻 |
| 号 | 3号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 前田 直見| 近藤 秀則| |
|---|---|
| 発行日 | 2013-12-02 |
| 出版物タイトル | 岡山医学会雑誌 |
| 巻 | 125巻 |
| 号 | 3号 |
| 資料タイプ | 学術雑誌論文 |