検索結果 - 岡山大学学術成果リポジトリ

The Early Decline of alpha-Fetoprotein and Des-gamma-Carboxy Prothrombin Predicts the Response of Hepatic Arterial Infusion Chemotherapy in Hepatocellular Carcinoma Patients

フルテキストURL	fulltext.pdf
著者	Yamamoto, Shumpei\| Onishi, Hideki\| Takaki, Akinobu\| Oyama, Atsushi\| Adachi, Takuya\| Wada, Nozomu\| Sakata, Masahiro\| Yasunaka, Tetsuya\| Shiraha, Hidenori\| Okada, Hiroyuki\|
キーワード	Hepatocellular carcinoma Hepatic arterial infusion chemotherapy Low-dose cisplatin plus 5-fluorouracil alpha-Fetoprotein Des-gamma-carboxy prothrombin
発行日	2020-04-21
出版物タイトル	Gastrointestinal Tumors
巻	7巻
号	3号
出版者	Karger
開始ページ	83
終了ページ	92
ISSN	2296-3774
NCID	AA12665877
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 The Author(s)
論文のバージョン	publisher
DOI	10.1159/000506941
Web of Science KeyUT	000551254300003
関連URL	isVersionOf https://doi.org/10.1159/000506941

Pembrolizumab-induced hypothyroidism caused reversible increased serum creatinine levels: a case report

フルテキストURL	fulltext.pdf
著者	Matsuoka, Natsumi\| Tsuji, Kenji\| Ichihara, Eiki\| Hara, Takayuki\| Fukushima, Kazuhiko\| Toma, Kishio\| Kitamura, Shinji\| Inagaki, Kenichi\| Sugiyama, Hitoshi\| Wada, Jun\|
キーワード	Pembrolizumab Hypothyroidism Creatinine Cystatin C
発行日	2020-03-31
出版物タイトル	BMC Nephrology
巻	21巻
出版者	BMC
開始ページ	113
ISSN	1471-2369
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s). 2020
論文のバージョン	publisher
PubMed ID	32234009
DOI	10.1186/s12882-020-01775-z
Web of Science KeyUT	000522961400004
関連URL	isVersionOf https://doi.org/10.1186/s12882-020-01775-z

Microstructure-dependent hydrogen diffusion and trapping in high-tensile steel

著者	Okayasu, Mitsuhiro\| Motojima, Jun\|
キーワード	High-tensile steel Hydrogen embrittlement Hydrogen trapping Hydrogen diffusion Carbide Lattice structure
発行日	2020-05-06
出版物タイトル	Materials Science and Engineering: A
巻	790巻
出版者	Elsevier
開始ページ	139418
ISSN	09215093
NCID	AA10720420
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 Elsevier B.V. All rights reserved.
DOI	10.1016/j.msea.2020.139418
関連URL	isVersionOf https://doi.org/10.1016/j.msea.2020.139418

Enhanced expression of nicotinamide nucleotide transhydrogenase (NNT) and its role in a human T cell line continuously exposed to asbestos

フルテキストURL	fulltext.pdf
著者	Yamamoto, Shoko\| Lee, Suni\| Matsuzaki, Hidenori\| Kumagai-Takei, Naoko\| Yoshitome, Kei\| Sada, Nagisa\| Shimizu, Yurika\| Ito, Tastsuo\| Nishimura, Yasumitsu\| Otsuki, Takemi\|
キーワード	Asbestos Continuous exposure Oxidative phosphorylation T cell nicotinamide nucleotide transhydrogenase (NNT)
発行日	2020-05-31
出版物タイトル	Environment International
巻	138巻
出版者	Elsevier
開始ページ	105654
ISSN	01604120
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 The Authors. Published by Elsevier Ltd.
論文のバージョン	publisher
PubMed ID	32187573
DOI	10.1016/j.envint.2020.105654
Web of Science KeyUT	000522749900026
関連URL	isVersionOf https://doi.org/10.1016/j.envint.2020.105654

Incarcerated Amyand’s Hernia

JaLCDOI	10.18926/AMO/58277
フルテキストURL	74_2_171.pdf
著者	Okita, Atsushi\| Yoshida, Osamu\| Murakami, Masakazu\|
抄録	A 76-year-old Japanese man was transferred to our hospital to undergo rehabilitation after traffic accident-related injuries. Seven days post-admission, he presented with abdominal pain and an 8-cm lump in the right inguinal region. He was diagnosed with an incarcerated inguinal hernia and underwent elective surgery the day after manual reduction. He had a normal vermiform appendix which was observed to have adhered to the right indirect hernia sac. An appendectomy and hernia repair using lightweight mesh were performed. We discuss the surgical management of this rare incarcerated Amyand’s hernia and the relevant literature.
キーワード	Amyand’s hernia incarcerated inguinal hernia appendectomy
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2020-04
巻	74巻
号	2号
出版者	Okayama University Medical School
開始ページ	171
終了ページ	174
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32341593
Web of Science KeyUT	000528278500012
NAID	120006839456

The Efficacy of Mirabegron for the Relief of Ureteral Stent-Related Symptoms

JaLCDOI	10.18926/AMO/58273
フルテキストURL	74_2_145.pdf
著者	Otsuki, Hideo\| Yamasaki, Tomoya\| Hori, Shunsuke\| Aoki, Hiroshi\| Kosaka, Takeo\| Uehara, Shinya\| Fujio, Kei\|
抄録	To investigate the efficacy of mirabegron for lower urinary tract symptoms in patients with an indwelling ureteral stent after ureterorenoscopic lithotripsy. This was a prospective follow-up study of 76 patients with stent-related symptoms (SRSs). Patients with upper urinary calculi who were pre-stented for > 2 weeks before lithotripsy were examined for the presence of SRSs by tests including the International Prostate Symptom Score (IPSS), OAB Symptom Score (OABSS), and urinary bother and pain measured by a Visual Analogue Scale (VAS) before lithotripsy. Mirabegron (50 mg/day) was prescribed post-lithotripsy for 2 weeks. SRSs were assessed at the time of stent removal. The IPSS scores improved significantly from 16.2 to 14.3 (p<0.001) and the IPSS-QoL scores decreased significantly from 5.0 to 4.6 (p=0.012). The OABSS scores improved significantly from 7.7 to 6.8 (p=0.006), and the urinary urgency scores (OABSS-Q3) decreased significantly from 3.24 to 2.68 (p<0.001). The number of nocturia episodes decreased significantly from 2.5 to 2.2 (p=0.045). Urinary bother and pain assessed by the VAS declined from 4.2 and 3.1 to 3.8 (p=0.15) and 2.5 (p=0.075), respectively. Mirabegron significantly improved SRSs and the number of nocturia episodes due to a ureteral stent.
キーワード	stent-related symptoms overactive bladder mirabegron ureterorenoscopic lithotripsy ureteral stent
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-04
巻	74巻
号	2号
出版者	Okayama University Medical School
開始ページ	145
終了ページ	150
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32341589
Web of Science KeyUT	000528278500008
NAID	120006839452

Mucinous Carcinoma of the Breast: Clinicopathological Features and Long-term Prognosis in Comparison with Invasive Ductal Cancer; A Single Hospital’s 30+-Year Experience

JaLCDOI	10.18926/AMO/58272
フルテキストURL	74_2_137.pdf
著者	Isozaki, Hiroshi\| Yamamoto, Yasuhisa\| Sakai, Kunihiko\| Sho, Tatuo\| Ishihara, Kiyohiro\| Murakami, Shigeki\| Matsumoto, Sasau\| Takama, Takehiro\|
抄録	Mucinous carcinoma (MC) of the breast is a rare and special type of malignancy, with a substantial amount of extracellular mucin. We compared the clinicopathological features and the long-term survival of MC patients with those of invasive ductal carcinoma-no special type (IDC-NST) patients, and we examined prognostic factors of MC. A total of 116 patients with mucinous carcinoma and 3,258 patients with IDC-NST who underwent surgery at our hospital (1977-2008) were enrolled. The 10-year overall survival rate and breast cancer-specific survival rate (BSS) of the MC patients (88.3%, 93.7%) were both significantly higher than those of IDC-NST patients (81.6%, 85.0%) (p=0.015, p=0.005, respectively). A Cox regression analysis demonstrated that MC tended to be an independent prognostic factor (hazard ratio 0.44, p=0.098). The BSS of the MC patients with positive lymph node (LN) metastasis was significantly poorer than that of the patients without it, by univariate analysis (p=0.002). The tumor size in the MC patients with positive LN metastasis (mean 3.2 cm) was significantly larger than that in the patients without it (mean 1.9 cm) (p=0.0004). Although a Cox regression analysis revealed no independent factor, MC patients with positive LN metastasis should be treated for advanced invasive ductal breast cancer.
キーワード	breast cancer mucinous carcinoma clinicopathological features long-term prognosis
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-04
巻	74巻
号	2号
出版者	Okayama University Medical School
開始ページ	137
終了ページ	143
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32341588
Web of Science KeyUT	000528278500007
NAID	120006839451

Association between Histological Types and Enhancement of Dynamic CT for Primary Lung Cancer

JaLCDOI	10.18926/AMO/58271
フルテキストURL	74_2_129.pdf
著者	Fukuma, Shogo\| Shinya, Takayoshi\| Soh, Junichi\| Fukuhara, Ryuichiro\| Ogawa, Nanako\| Higaki, Fumiyo\| Tanaka, Takehiro\| Ichihara, Eiki\| Hiraki, Takao\| Toyooka, Shinichi\| Kanazawa, Susumu\|
抄録	The aim of this study was to explore enhancement patterns of different types of primary lung cancers on 2-phase dynamic computed tomography (CT). This study included 217 primary lung cancer patients (141 adenocarcinomas [ADs], 48 squamous cell carcinomas [SCCs], 20 small cell lung carcinomas [SCLCs], and 8 others) who were examined using a 2-phase dynamic scan. Regions of interest were identified and mean enhancement values were calculated. After excluding the 20 SCLCs because these lesions had different clinical stages from the other cancer types, the mean attenuation values and subtractions between phases were compared between types of non-small cell lung carcinomas (NSCLCs) using the Kruskal–Wallis test. Late phase attenuation and attenuation of the late minus unenhanced phase (LMU) of SCCs were significantly higher than those of ADs (p<0.05). To differentiate SCC and AD in the late phase, a threshold of 80.21 Hounsfield units (HU) gave 52.9% accuracy. In LMU, a threshold of 52.16 HU gave 59.3% accuracy. Dynamic lung CT has the potential to aid in differentiating among NSCLC types.
キーワード	differentiation dynamic computed tomography primary lung cancer enhancement pattern
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-04
巻	74巻
号	2号
出版者	Okayama University Medical School
開始ページ	129
終了ページ	135
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32341587
Web of Science KeyUT	000528278500006
NAID	120006839450

Effect of prostaglandin D2 on VEGF release by nasal polyp fibroblasts

フルテキストURL	fulltext.pdf fulltext2.pdf
著者	Kanai, Kengo\| Okano, Mitsuhiro\| Fujiwara, Tazuko\| Kariya, Shin\| Haruna, Takenori\| Omichi, Ryotaro\| Makihara, Sei-ichiro\| Hirata, Yuji\| Nishizaki, Kazunori\|
キーワード	CRTH2 DP Nasal polyp fibroblast PGD2 VEGF
発行日	2016-10
出版物タイトル	Allergology International
巻	65巻
号	4号
出版者	Elsevier
開始ページ	414
終了ページ	419
ISSN	1323-8930
NCID	AA11091750
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2016, Japanese Society of Allergology.
論文のバージョン	publisher
PubMed ID	27091669
DOI	10.1016/j.alit.2016.03.003
Web of Science KeyUT	000385500400010
関連URL	isVersionOf https://doi.org/10.1016/j.alit.2016.03.003

Cavity Adaptation of Composite Restorations Prepared at Crown and Root: Optical Assessment Using SS-OCT

フルテキストURL	DMJ38_5_779.pdf
著者	Rima Zakzuk Alshahni\| Shimada, Yasushi\| Zhou, Yuan\| Yoshiyama, Masahiro\| Sadr, Alireza\| Sumi, Yasunori\| Tagami, Junji\|
キーワード	Bottom Dentin-enamel junction Gap SS-OCT Self-etch adhesive
発行日	2019-09-27
出版物タイトル	Dental Materials Journal
巻	38巻
号	5号
出版者	Japanese Society for Dental Materials and Devices
開始ページ	779
終了ページ	789
ISSN	0287-4547
NCID	AA10443149
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2019 The Japanese Society for Dental Materials and Devices
論文のバージョン	publisher
PubMed ID	31341148
DOI	10.4012/dmj.2018-265
Web of Science KeyUT	000500359500013
関連URL	isVersionOf https://doi.org/10.4012/dmj.2018-265

Serum IgG4 as a biomarker reflecting pathophysiology and post-operative recurrence in chronic rhinosinusitis

フルテキストURL	fulltext.pdf
著者	Oka, Aiko\| Ninomiya, Takahiro\| Fujiwara, Tazuko\| Takao, Soshi\| Sato, Yasuharu\| Gion, Yuka\| Minoura, Akira\| Haruna, Shin-ichi\| Yoshida, Naohiro\| Sakuma, Yasunori\| Izuhara, Kenji\| Ono, Junya\| Taniguchi, Masami\| Haruna, Takenori\| Higaki, Takaya\| Kariya, Shin\| Koyama, Takahisa\| Takabayashi, Tetsuji\| Imoto, Yoshimasa\| Sakashita, Masafumi\| Kidoguchi, Masanori\| Nishizaki, Kazunori\| Fujieda, Shigeharu\| Okano, Mitsuhiro\|
キーワード	Chronic rhinosinusitis Eosinophils Eosinophils IgG4 Severity Surgery
発行日	2020-01-14
出版物タイトル	Allergology International
出版者	Elsevier
ISSN	13238930
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2019 Japanese Society of Allergology. Production and hosting by Elsevier B.V.
論文のバージョン	publisher
PubMed ID	31952913
DOI	10.1016/j.alit.2019.12.004
関連URL	isVersionOf https://doi.org/10.1016/j.alit.2019.12.004

Mechanical and fatigue properties of long carbon fiber reinforced plastics at low temperature

フルテキストURL	fulltext.pdf
著者	Okayasu, Mitsuhiro\| Tsuchiya, Yuki\|
キーワード	CFRP Carbon fiber Tensile strength Fatigue strength Low temperature
発行日	2019-10-14
出版物タイトル	Journal of Science: Advanced Materials and Devices
巻	4巻
号	4号
出版者	Vietnam National University
開始ページ	577
終了ページ	583
ISSN	24682179
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2019 Publishing services by Elsevier B.V. on behalf of Vietnam National University, Hanoi.
論文のバージョン	publisher
DOI	10.1016/j.jsamd.2019.10.002
Web of Science KeyUT	000504059200011
関連URL	isVersionOf https://doi.org/10.1016/j.jsamd.2019.10.002

Evaluation of IAEA Clearance Concept for Low-level Radioactive Waste from a Radioisotope Research Institute

フルテキストURL	HP110_5_2_S81.pdf Fig.pdf Table.pdf
著者	Yumoto, Yasuhiro\| Okada, Shigeru\| Kinno, Ikuo\| Nagamatsu, Tomohiro\| Nouso, Kazuhiro\| Nakayama, Eiichi\|
キーワード	operational topics waste low-level waste disposal waste management
発行日	2016-05
出版物タイトル	Health Physics
巻	110巻
号	5 S2号
出版者	LWW
開始ページ	S81
終了ページ	S87
ISSN	0017-9078
NCID	AA00662510
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	27023155
DOI	10.1097/HP.0b013e318254aef6
Web of Science KeyUT	000373920200006
関連URL	isVersionOf https://doi.org/10.1097/HP.0b013e318254aef6

Phase II Trial Using Romidepsin after Gemcitabine, Dexamethasone, and Cisplatin Therapy in Elderly Transplant-Ineligible Patients with Relapsed/Refractory Peripheral T-Cell Lymphoma: Study Protocol

JaLCDOI	10.18926/AMO/57379
フルテキストURL	73_5_469.pdf
著者	Yamasaki, Satoshi\| Kada, Akiko\| Nagai, Hirokazu\| Yoshida, Isao\| Choi, Ilseung\| Saito, Akiko M.\| Iwasakia, Hiromi\|
抄録	Romidepsin is an important therapeutic option for patients with peripheral T-cell lymphoma (PTCL). However, the timing of romidepsin administration remains controversial. Romidepsin was launched in Japan as a consolidation therapy agent after conventional salvage chemotherapy with gemcitabine, dexamethasone, and cisplatin (GDP). GDP therapy will be administered every 3 weeks. If complete response, partial response, or stable disease is confirmed after 2-4 GDP cycles, romidepsin will be administered every 4 weeks. The primary endpoint is a 2-year progression-free survival rate. Patients participating in this study and undergoing treatment can expect results similar to or better than those of conventional therapies.
キーワード	peripheral T-cell lymphoma not otherwise specified angioimmunoblastic T-cell lymphoma gemcitabine cisplatin, romidepsin
Amo Type	Clinical Study Protocol
出版物タイトル	Acta Medica Okayama
発行日	2019-10
巻	73巻
号	5号
出版者	Okayama University Medical School
開始ページ	469
終了ページ	474
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31649375
Web of Science KeyUT	000491886600014

Comparison of Two Different Drugs for Overactive Bladder, Solifenacin and Mirabegron: A Prospective Randomized Crossover Study

JaLCDOI	10.18926/AMO/57368
フルテキストURL	73_5_387.pdf
著者	Inoue, Miyabi\| Yokoyama, Teruhiko\|
抄録	To assess the efficacy and safety of 2 drugs for overactive bladder (OAB), solifenacin and mirabegron. Fortyseven female OAB patients were randomized into 2 groups. Twenty-three patients were initially prescribed solifenacin for 4 weeks, followed by mirabegron for 4 weeks (group S). The other 24 patients were initially prescribed mirabegron for 4 weeks, followed by solifenacin for 4 weeks (group M). Evaluations included clinical determination of the OAB symptom score (OABSS), International Prostate Symptom Score (IPSS), and Visual Analog Scale. The IPSS significantly improved after the administration of solifenacin in both groups. The OABSS significantly improved in both groups after 4 weeks. In group M, the OABSS after eight weeks was significantly improved compared to that after 4 weeks. However, in group S, it was not significantly improved. Twelve patients experienced adverse events during the solifenacin treatment, while 2 patients experienced adverse events during the mirabegron treatment. Both solifenacin and mirabegron led to improved OAB symptoms. Switching from mirabegron to solifenacin significantly improved the OABSS. However, mirabegron led to fewer adverse events than solifenacin. We recommend that mirabegron be prescribed first for OAB patients. If patients are not satisfied with mirabegron, solifenacin should be used.
キーワード	overactive bladder, randomized crossover study solifenacin mirabegron
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2019-10
巻	73巻
号	5号
出版者	Okayama University Medical School
開始ページ	387
終了ページ	392
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31649364
Web of Science KeyUT	000491886600003

Histidine-rich Glycoprotein Modulates the Blood-vascular System in Septic Condition

JaLCDOI	10.18926/AMO/57366
フルテキストURL	73_5_379.pdf
著者	Wake, Hidenori\|
抄録	Histidine-rich glycoprotein (HRG) is a 75 kDa glycoprotein synthesized in the liver whose plasma concentration is 100-150 μg/ml. HRG has been shown to modulate sepsis-related biological reactions by binding to several substances and cells, including heparin, factor XII, fibrinogen, thrombospondin, plasminogen, C1q, IgG, heme, LPS, dead cells, bacteria, and fungi. Therefore, reduction of plasma HRG levels in sepsis leads to dysregulation of coagulation, fibrinolysis, and immune response, resulting in disseminated intravascular coagulation and multiple organ failure. This review summarizes the binding and functional properties of HRG in sepsis.
キーワード	htidine-rich glycoprotein septic pathogenesis immunothrombosis
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2019-10
巻	73巻
号	5号
出版者	Okayama University Medical School
開始ページ	379
終了ページ	382
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31649362
Web of Science KeyUT	000491886600001

Significance of IgG4-positive cells in severe eosinophilic chronic rhinosinusitis

フルテキストURL	fulltext.pdf
著者	Koyama, Takahisa\| Kariya, Shin\| Sato, Yasuharu\| Gion, Yuka\| Higaki, Takaya\| Haruna, Takenori\| Fujiwara, Tazuko\| Minoura, Akira\| Takao, Soshi\| Orita, Yorihisa\| Kanai, Kengo\| Taniguchi, Masami\| Nishizaki, Kazunori\| Okano, Mitsuhiro\|
キーワード	Chronic rhinosinusitis Eosinophils IgG4 Nasal polyps Severity
発行日	2019-04-30
出版物タイトル	Allergology International
巻	68巻
号	2号
出版者	Elsevier
開始ページ	216
終了ページ	224
ISSN	13238930
NCID	AA11091750
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2019 Japanese Society of Allergology. Production and hosting by Elsevier B.V.
論文のバージョン	publisher
PubMed ID	30316748
DOI	10.1016/j.alit.2018.09.002
Web of Science KeyUT	000462852200012
関連URL	isVersionOf https://doi.org/10.1016/j.alit.2018.09.002

Construction and Characterization of a PGN_0297 Mutant of Porphyromonas gingivalis: Evidence of the Contribution of PGN_0297 to Gingipain Activity

JaLCDOI	10.18926/AMO/56933
フルテキストURL	73_4_315.pdf
著者	Ono, Shintaro\| Nakayama, Masaaki\| Tachibana, Masato\| Abu Saleh Muhammad Shahriar\| Heling, Wang\| Takashiba, Shogo\| Ohara, Naoya\|
抄録	The periodontal pathogen Porphyromonas gingivalis shows colonial pigmentation on blood agar and produces gingipains (Kgp, RgpA, and RgpB), cysteine proteases involved in an organism’s virulence and pigmentation. We showed previously that deletion of the PGN_0300 gene abolished the pigmentation activity and reduced the proteolytic activity of gingipains. The role of the PGN_0297 gene, which consists of an operon with the PGN_0300 gene, is unclear. Herein we examined the effect of PGN_0297 gene deletion on the pigmentation and proteolytic activities and transcriptional levels of gingipains. A PGN_0297 gene deletion mutant (ΔPGN_0297) did not exhibit the pigmentation. The proteolytic activity of the gingipains was decreased in the culture supernatant and on the cell surface of ΔPGN_0297. The mutant ΔPGN_0297 failed to attenuate Akt phosphorylation at Thr308 and Ser473, but both phosphorylations were attenuated in the wild-type and its complementation strain. The deletion of PGN_0297 gene did not substantially affect the transcriptional levels of the gingipain genes kgp, rgpA, and rgpB. Taken together, these results indicate that PGN_0297 is closely involved in the secretion and maturation of gingipains.
キーワード	periodontitis Porphyromonas gingivalis gingipain C-terminal domain secretion system
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2019-08
巻	73巻
号	4号
出版者	Okayama University Medical School
開始ページ	315
終了ページ	323
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31439954

Tuberosity-overlapping Fixation of the Humeral Shaft in Humeral Head Replacement Surgery

JaLCDOI	10.18926/AMO/56931
フルテキストURL	73_4_299.pdf
著者	Hiranaka, Takaaki\| Nishida, Keiichiro\| Konishiike, Taizo\| Ozaki, Toshifumi\| Mikasa, Motohiko\|
抄録	The fixation technique of bony fragments is crucial for the bone union of the tuberosities after humeral head replacement (HHR) for a comminuted fracture of the proximal humerus. To increase the bone union rate, we reduce tuberosities to overlap on the humeral shaft by approx. 1 cm and fix them with cable wire. Herein, we retrospectively investigated the clinical and radiographic outcomes of our procedure. Twenty-six patients who underwent cementless HHR for the treatment of comminuted fractures of the proximal humerus were investigated. The Constant-Murley score, active shoulder mobility, and bone union rate were evaluated. The mean duration of follow-up was 56.3 months (range 24-197). At the final follow-up, the average Constant-Murley score was 58 (range 40-76). Forward elevation was 126° on average (range 35°-180°). Twenty-three cases (88%) showed bone union between the tuberosities and the shaft at an average follow-up of 4.1 months (range 4-5 months) after surgery. Non-union was noted in 1 case, and bone resorption was noted in 2 cases. The bone union rate and the clinical outcome of our procedure were relatively favorable
キーワード	humeral head replacement tuberosity-overlapping technique bone union of tuberosities cable wire cementless stem
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2019-08
巻	73巻
号	4号
出版者	Okayama University Medical School
開始ページ	299
終了ページ	305
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31439952

Method to Suppress Isobaric and Polyatomic Interferences for Measurements of Highly Siderophile Elements in Desilicified Geological Samples

フルテキストURL	GeostandardsGeoanalyticalRes_2019.pdf
著者	Zhou, Xiaoyu\| Tanaka, Ryoji\| Yamanaka, Masahiro\| Sakaguchi, Chie\| Nakamura, Eizo\|
キーワード	highly siderophile elements desilicification isotope dilution method high resolution ICP-MS N-TIMS
発行日	2019-03-20
出版物タイトル	Geostandards and Geoanalytical Research
巻	43巻
号	4号
出版者	John Wiley
開始ページ	611
終了ページ	633
ISSN	16394488
NCID	AA11984494
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
DOI	10.1111/ggr.12280
Web of Science KeyUT	000474428700001
関連URL	isVersionOf https://doi.org/10.1111/ggr.12280