検索結果 47501 件
| 著者 | Tani, Makiko| Morimatsu, Hiroshi| Takatsu, Fumiaki| Morita, Kiyoshi| |
|---|---|
| 発行日 | 2012 |
| 出版物タイトル | The Scientific World Journal |
| 巻 | 2012巻 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Komatsu, Seiji| Nagai, Yusuke| Naruse, Keiji| Kimata, Yoshihiro| |
|---|---|
| 発行日 | 2014-07-21 |
| 出版物タイトル | PLoS ONE |
| 巻 | 9巻 |
| 号 | 7号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Nishikawa, Hitoshi| Oto, Takahiro| Otani, Shinji| Harada, Masaaki| Iga, Norichika| Miyoshi, Kentaroh| Miyoshi, Shinichiro| |
|---|---|
| 発行日 | 2013-12 |
| 出版物タイトル | The Journal of Thoracic and Cardiovascular Surgery |
| 巻 | 146巻 |
| 号 | 6号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Fujii, K| Kurozumi, K| Ichikawa, T| Onishi, M| Shimazu, Y| Ishida, J| Chiocca, EA| Kaur, B| Date, I| |
|---|---|
| 発行日 | 2013-08 |
| 出版物タイトル | Cancer Gene Therapy |
| 巻 | 20巻 |
| 号 | 8号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Hirai, Misato| Maeda, Yukihide| Fukushima, Kunihiro| Sugaya, Akiko| Kataoka, Yuko| Nishizaki, Kazunori| |
|---|---|
| 発行日 | 2011-09-14 |
| 出版物タイトル | NeuroReport |
| 巻 | 22巻 |
| 号 | 13号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Itami, Hisakazu| Tokunaga, Koji| Okuma, Yu| Hishikawa, Tomohito| Sugiu, Kenji| Ida, Kentaro| Date, Isao| |
|---|---|
| 発行日 | 2013-09 |
| 出版物タイトル | Neuroradiology |
| 巻 | 55巻 |
| 号 | 9号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Yano, Shuya| Tazawa, Hiroshi| Hashimoto, Yuuri| Shirakawa, Yasuhiro| Kuroda, Shinji| Nishizaki, Masahiko| Kishimoto, Hiroyuki| Uno, Futoshi| Nagasaka, Takeshi| Urata, Yasuo| Kagawa, Shunsuke| Hoffman, Robert M.| Fujiwara, Toshiyoshi| |
|---|---|
| 発行日 | 2013-12-01 |
| 出版物タイトル | Clinical Cancer Research |
| 巻 | 19巻 |
| 号 | 23号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/52792 |
|---|---|
| フルテキストURL | 68_4_253.pdf |
| 著者 | Oozawa, Susumu| Sano, Shunji| Nishibori, Masahiro| |
| 抄録 | Atherosclerosis is often associated with chronic vascular inflammation. High-mobility group box 1 protein (HMGB1) plays various roles, not only as a transcriptional regulatory factor in the nucleus, but also as an inflammatory mediator. A previous study suggested that fibrinogen is an important factor associated with atherosclerosis progression. The present study was performed to examine the levels of plasma HMGB1 protein in atherosclerosis patients. We studied 24 patients with peripheral artery disease (PAD) with atherosclerosis, and 10 healthy controls. We found that the concentrations of HMGB1 were increased in the plasma of the patients with atherosclerosis, and there were significant correlations between the plasma HMGB1 and fibrinogen levels. Plasma HMGB1 may play a key role in the pathogenesis of clinical and experimental atherosclerosis. |
| キーワード | HMGB1 fibrinogen atherosclerosis peripheral artery disease |
| Amo Type | Erratum |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2014-08 |
| 巻 | 68巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 253 |
| 終了ページ | 253 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| Web of Science KeyUT | 000340687500008 |
| 関連URL | http://doi.org/10.18926/AMO/52656 |
| JaLCDOI | 10.18926/AMO/52791 |
|---|---|
| フルテキストURL | 68_4_249.pdf |
| 著者 | Ogawara, Yuya| Tachibana, Tomoyasu| Orita, Yorihisa| Uchino, Kaori| Wani, Yoji| Nagahiro, Itaru| Matsuyama, Yuko| Abe, Iku| Fujisawa, Masayoshi| Nishizaki, Kazunori| |
| 抄録 | We describe an extremely rare case of tracheal stenosis caused by unnoticed microscopic fiber-like foreign bodies. A 66-year-old woman complained of dyspnea with inspiratory stridor. Magnifying electroendoscopy and computed tomography revealed stenosis involving the entire circumference of the tracheal lumen. Tracheotomy and biopsy were performed. Histologically, the lesion showed chronic inflammation with a deposition of fiber-like foreign bodies. The patient had no history of trauma or inhalation injury, but had undergone intratracheal intubation on 4 occasions. The lesion was incised using semiconductor laser photoresection, and the postoperative course was good. To the best of our knowledge, this represents the first report in the English literature of tracheal stenosis caused by unnoticed foreign bodies. The origin of these fiber-like foreign bodies remains unclear but might be related to chronic inflammation resulting from intratracheal intubations. |
| キーワード | tracheal stenosis fibrous foreign body intubation tracheotomy laser |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2014-08 |
| 巻 | 68巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 249 |
| 終了ページ | 252 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25145411 |
| Web of Science KeyUT | 000340687500007 |
| JaLCDOI | 10.18926/AMO/52790 |
|---|---|
| フルテキストURL | 68_4_243.pdf |
| 著者 | Wada, Nozomu| Yasunaka, Tetsuya| Ikeda, Fusao| Nishina, Sohji| Korenaga, Masaaki| Hino, Keisuke| Fujioka, Shin-ichi| Osawa, Toshiya| Itoshima, Tatsuya| Kawanaka, Miwa| Yamada, Gotaro| Kariyama, Kazuya| Takayama, Hiroki| Kubota, Junichi| Morimoto, Yoichi| Mizushima, Takaaki| Yamashita, Haruhiko| Tanioka, Hiroaki| Negoro, Yuji| Toshimori, Junichi| Kobashi, Haruhiko| Hirano, Atsushi| Itano, Yasuo| Takaki, Akinobu| Yamamoto, Kazuhide| |
| 抄録 | Hepatitis B virus (HBV) is one of the major viruses causing acute hepatitis. Recently, the incidence of acute hepatitis with genotype A has been increasing in Japan. The aim of this study was to investigate acute hepatitis B (AHB) in Okayama prefecture, with special attention to HBV genotype A. AHB patients who visited one of 12 general hospitals in Okayama prefecture between 2006 and 2010 were retrospectively analyzed. Over the course of the study period, 128 patients were diagnosed with AHB. Sexual transmission was supposed in the majority of patients (78 patients, 61%), including 59 (76%) having sex with heterosexual partners. The genotypes of HBV were assessed in 90 patients (70%), of whom 27 patients were infected with genotype A, 5 with genotype B, and 58 with genotype C. The prevalence of genotype A was significantly higher among male patients (28.7%), aged 20-29 (35.6%, p＜0.01), among men who had sex with men (100%, p＜0.005), and among patients having sex with unspecified partners (44.8%, p＜0.005). Genotype A was not a significant factor associated with delayed HBsAg disappearance. Caution should be exercised with regard to sexually transmissible diseases in order to slow the pandemic spread of AHB due to genotype A. |
| キーワード | acute hepatitis hepatitis B virus |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2014-08 |
| 巻 | 68巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 243 |
| 終了ページ | 247 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25145410 |
| Web of Science KeyUT | 000340687500006 |
| JaLCDOI | 10.18926/AMO/52789 |
|---|---|
| フルテキストURL | 68_4_235.pdf |
| 著者 | Ono, Tetsuichiro| Shikata, Kenichi| Obika, Mikako| Miyatake, Nobuyuki| Kodera, Ryo| Hirota, Daisyo| Wada, Jun| Kataoka, Hitomi| Ogawa, Daisuke| Makino, Hirofumi| |
| 抄録 | The aim of this study was to clarify the factors associated with the remission and/or regression of microalbuminuria in Japanese patients with type 2 diabetes mellitus. We retrospectively analyzed the data of 130 patients with type 2 diabetes mellitus with microalbuminuria for 2-6 years (3.39±1.31 years). Remission was defined as improving from microalbuminuria to normoalbuminuria using the albumin/creatinine ratio (ACR), and regression of microalbuminuria was defined as a decrease in ACR of 50% or more from baseline. Progression of microalbuminuria was defined as progressing from microalbuminuria to overt proteinuria during the follow-up period. Among 130 patients with type 2 diabetes mellitus with microalbuminuria, 57 and 13 patients were defined as having remission and regression, respectively, while 26 patients progressed to overt proteinuria. Sex (female), higher HDL cholesterol and lower HbA1c were determinant factors associated with remission/regression of microalbuminuria by logistic regression analysis. Lower systolic blood pressure (SBP) was also correlated with remission/regression, but not at a significant level. These results suggest that proper control of blood glucose, BP and lipid profiles may be associated with remission and/or regression of type 2 diabetes mellitus with microalbuminuria in clinical practice. |
| キーワード | microalbuminuria type 2 diabetes mellitus remission regression |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2014-08 |
| 巻 | 68巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 235 |
| 終了ページ | 241 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25145409 |
| Web of Science KeyUT | 000340687500005 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/52828 |
| JaLCDOI | 10.18926/AMO/52788 |
|---|---|
| フルテキストURL | 68_4_219.pdf |
| 著者 | Hinamoto, Norikazu| Maeshima, Yohei| Saito, Daisuke| Yamasaki, Hiroko| Tanabe, Katsuyuki| Nasu, Tatsuyo| Watatani, Hiroyuki| Ujike, Haruyo| Kinomura, Masaru| Sugiyama, Hitoshi| Sonoda, Hikaru| Kanomata, Naoki| Sato, Yasufumi| Makino, Hirofumi| |
| 抄録 | Experimental studies have demonstrated the involvement of angiogenesis-related factors in the progression of chronic kidney disease (CKD). There have so far been no reports investigating the distribution and clinical roles of Vasohibin-1 (VASH-1), a negative feedback regulator of angiogenesis, in CKD. We recruited 54 Japanese CKD patients and 6 patients who had normal renal tissues excised due to localized renal cell carcinoma. We evaluated the correlations between the renal expression level of VASH-1 and the clinical/histological parameters. VASH-1 was observed in renal endothelial/mesangial cells, crescentic lesions and interstitial inflammatory cells. Significant positive correlations were observed between 1) crescent formation and the number of VASH-1+ cells in the glomerulus (r＝0.48, p＝0.001) or cortex (r＝0.64, p＜0.0001), 2) interstitial cell infiltration and the number of VASH-1+ cells in the cortex (r＝0.34, p＝0.02), 3) the glomerular VEGFR-2+ area and the number of VASH-1+ cells in the glomerulus (r＝0.44, p＝0.01) or medulla (r＝0.63, p＝0.01). These results suggest that the renal levels of VASH-1 may be affected by local inflammation, crescentic lesions and VEGFR-2. |
| キーワード | chronic kidney disease inflammation Vasohibin-1 VEGF-A VEGFR-2 |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2014-08 |
| 巻 | 68巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 219 |
| 終了ページ | 233 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25145408 |
| Web of Science KeyUT | 000340687500004 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/52824 |
| JaLCDOI | 10.18926/AMO/52787 |
|---|---|
| フルテキストURL | 68_4_207.pdf |
| 著者 | Yu, Liling| Kato, Yutaka| Shishido, Keisuke| Doi, Hideko| Jin, Haeng mi| Wang, Jin gang| Ikezawa, Junko| Awaya, Tsuyoshi| |
| 抄録 | This study examines the attitudes of young Japanese, Chinese, and South Koreans toward birth and child-rearing. The survey targeted four-year university students (n＝1,668) who responded to an anonymous survey using self-report questionnaires between December 2012 and April 2013. The collection rates were 72.5%, 94.7%, and 96.5% for the Japanese, Chinese, and South Korean students, respectively. Correlations among the respondentsʼ attributes, medical and scientific literacy levels, and views of preferred qualities of children were analyzed using chi-square test, supplemented by residual analysis (significance level set at p＜0.05). Participants were asked whether they were willing to use the following methods for obtaining preferred qualities in their children:(1) choosing a spouse (43.2%, 72.6%, and 85.1% of the Japanese, Chinese, and South Koreans, respectively, agreed);(2) using a sperm bank (cryobank) (5.8%, 60.1%, and 81.7% of the Japanese, Chines, and South Koreans, respectively, agreed);and (3) using an egg cell bank (ova bank or cryobank) (5.3%, 47.2%, and 70.3% of the Japanese, Chinese, and South Koreans, respectively, agreed). The proportion of affirmative responses (indicating “eugenic inclination”) to these statements was significantly higher among the Chinese and South Korean participants than their Japanese counterparts (p＜0.001). Significant differences were also found in the attitudes of the 3 groups toward methods for obtaining the preferred qualities for their children:prenatal diagnosis, pre-implantation diagnosis, the environment during pregnancy, and child-rearing. |
| キーワード | prenatal diagnosis pre-implantation diagnosis delivery and child-rearing eugenics healthy birth and child-rearing |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2014-08 |
| 巻 | 68巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 207 |
| 終了ページ | 218 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25145407 |
| Web of Science KeyUT | 000340687500003 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/52823 |
| JaLCDOI | 10.18926/AMO/52786 |
|---|---|
| フルテキストURL | 68_4_201.pdf |
| 著者 | Endo, Hirosuke| Akazawa, Hirofumi| Mitani, Shigeru| Okada, Yoshiki| Yamane, Kentaro| Ozaki, Toshifumi| |
| 抄録 | We reviewed the treatment outcome in 14 hips of 7 patients who were diagnosed as having bilateral developmental dislocation of the hip (DDH) after walking age and could be followed up until they were at least 14 years of age. Based on the results of two-directional arthrography of the hip, closed reduction was performed in 2 hips, and open reduction was performed without osteotomy in 12 hips. The final radiographic evaluations were made according to the Kalamchi and MacEwen classification and Severin classification. The mean age at the initial visit was 1 year and 9 months (range, 1 year and 5 months to 3 years). The outcome was satisfactory for one hip in Group Ⅰ and 2 hips in Group Ⅱ according to the Kalamchi and MacEwen classification, and in 83% of the Severin Class Ⅰ and Ⅱ hips. Arthrography was useful for identifying asymmetry, demonstrating the usefulness of a treatment strategy based on arthrography of the hip. |
| キーワード | developmental dislocation of the hip bilateral case arthrogram open reduction after walking age |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2014-08 |
| 巻 | 68巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 201 |
| 終了ページ | 206 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25145406 |
| Web of Science KeyUT | 000340687500002 |
| JaLCDOI | 10.18926/AMO/52785 |
|---|---|
| フルテキストURL | 68_4_191.pdf |
| 著者 | Shien, Kazuhiko| Yamamoto, Hiromasa| Soh, Junichi| Miyoshi, Shinichiro| Toyooka, Shinichi| |
| 抄録 | Non-small cell lung cancer (NSCLC) harboring an activating mutation within the epidermal growth factor receptor (EGFR) was defined as a clinically distinct molecular group. These lesions show oncogene addiction to EGFR and dramatic responses to the EGFR tyrosine kinase inhibitors (TKIs). Several large Phase III trials have shown that EGFR-TKIs improved the progression-free survival of patients with EGFR mutant NSCLC compared to conventional chemotherapy. However, the long-term effectiveness of EGFR-TKIs is usually limited because of acquired drug resistance. To overcome this resistance to EGFR-TKIs, it will be essential to identify the specific mechanisms underlying the resistance. Many investigators have attempted to identify the mechanisms using preclinical models and drug-resistant clinical samples. As a result, several mechanisms have been showed to be responsible for the resistance, but not all of the relevant mechanisms have been uncovered. In this review, we provide an overview of mechanisms underlying drug-resistance to EGFR-TKIs, focusing on results obtained with preclinical models, and we present some possible strategies to overcome the EGFR-TKI resistance. |
| キーワード | non-small cell lung cancer EGFR mutation tyrosine-kinase inhibitor drug resistance cancer stem cell |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2014-08 |
| 巻 | 68巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 191 |
| 終了ページ | 200 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25145405 |
| Web of Science KeyUT | 000340687500001 |
| 著者 | Hayakawa, Hiromi| Ichihara, Eiki| Ohashi, Kadoaki| Ninomiya, Takashi| Yasugi, Masayuki| Takata, Saburo| Sakai, Katsuya| Matsumoto, Kunio| Takigawa, Nagio| Tanimoto, Mitsune| Kiura, Katsuyuki| |
|---|---|
| 発行日 | 2013-11 |
| 出版物タイトル | Cancer Science |
| 巻 | 104巻 |
| 号 | 11号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Kurahashi, Hiroaki| Watanabe, Masami| Sugimoto, Morito| Ariyoshi, Yuichi| Mahmood, Sabina| Araki, Motoo| Ishii, Kazushi| Nasu, Yasutomo| Nagai, Atsushi| Kumon, Hiromi| |
|---|---|
| 発行日 | 2013-12 |
| 出版物タイトル | Endocrine Journal |
| 巻 | 60巻 |
| 号 | 12号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Hayashi, Tatsuro| Asano, Hiroaki| Toyooka, Shinichi| Tsukuda, Kazunori| Soh, Junichi| Shien, Tadahiko| Taira, Naruto| Maki, Yuho| Tanaka, Norimitsu| Doihara, Hiroyoshi| Nasu, Yasutomo| Huh, Nam-ho| Miyoshi, Shinichiro| |
|---|---|
| 発行日 | 2012-05 |
| 出版物タイトル | Journal of Cancer Research and Clinical Oncology |
| 巻 | 138巻 |
| 号 | 5号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 岡山大学大学院教育学研究科| |
|---|---|
| 発行日 | 2014-07-28 |
| 出版物タイトル | 岡山大学大学院教育学研究科研究集録 |
| 巻 | 156巻 |
| 資料タイプ | その他 |
| 著者 | 岡山大学大学院教育学研究科| |
|---|---|
| 発行日 | 2014-07-28 |
| 出版物タイトル | 岡山大学大学院教育学研究科研究集録 |
| 巻 | 156巻 |
| 資料タイプ | その他 |