検索結果 48298 件
著者 | 磯野 嵩| |
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発行日 | 2015-10-31 |
出版物タイトル | 岡山大学算数・数学教育学会誌 : パピルス |
巻 | 22巻 |
資料タイプ | 紀要論文 |
著者 | 黒﨑 東洋郎| |
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発行日 | 2015-10-31 |
出版物タイトル | 岡山大学算数・数学教育学会誌 : パピルス |
巻 | 22巻 |
資料タイプ | その他 |
著者 | 岡山大学算数・数学教育学会| |
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発行日 | 2015-10-31 |
出版物タイトル | 岡山大学算数・数学教育学会誌 : パピルス |
巻 | 22巻 |
資料タイプ | その他 |
著者 | 岡山大学算数・数学教育学会| |
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発行日 | 2015-10-31 |
出版物タイトル | 岡山大学算数・数学教育学会誌 : パピルス |
巻 | 22巻 |
資料タイプ | その他 |
著者 | 曽我 賢彦| Maeda, Yoshinobu| Tanimoto, Mitsune| Ebinuma, Takayuki| Maeda, Hiroshi| Takashiba, Shogo| |
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発行日 | 2013-02 |
出版物タイトル | Supportive Care in Cancer |
巻 | 21巻 |
号 | 2号 |
資料タイプ | 学術雑誌論文 |
著者 | Okui, Akemi| Soga, Yoshihiko| Kokeguchi, Susumu| Nose, Motoko| Yamanaka, Reiko| Kusano, Nobuchika| Morita, Manabu| |
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発行日 | 2015-07-15 |
出版物タイトル | Internal Medicine |
巻 | 54巻 |
号 | 14号 |
資料タイプ | 学術雑誌論文 |
JaLCDOI | 10.18926/AMO/53680 |
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フルテキストURL | 69_5_325.pdf |
著者 | Okada, Yoshiki| Endo, Hirosuke| Mitani, Shigeru| Fujiwara, Kazuo| Tetsunaga, Tomonori| Kagawa, Yohei| Fujii, Yosuke| Kunisada, Toshiyuki| Ozaki, Toshifumi| |
抄録 | Total hip arthroplasty (THA) is the most effective treatment for advanced or end-stage hip osteoarthritis. However, venous thromboembolism (VTE) remains one of its unresolved complications. We reviewed the records of 322 patients undergoing primary THA and investigated the efficacy of anticoagulant prophylaxis for VTE. Our study cohort consisted of 60 patients who received no anticoagulants, 100 patients who received a factor Xa inhibitor (fondaparinux), 100 patients who received low molecular weight heparin (enoxaparin), and 62 patients who selectively received no anticoagulant prophylaxis due to perioperative bleeding, weight, and/or hemoglobin concentration. Enhanced 64-slice multidetector row computed tomography was performed postoperatively for 7 days in all cases. The incidence of VTE in the four groups was 15%, 9.0%, 6.0%, and 6.4%, respectively. The incidence of VTE was significantly lower in the groups receiving anticoagulant prophylaxis and the group selectively receiving no anticoagulant prophylaxis than in the group receiving no anticoagulants. Complications of fondaparinux therapy included hepatic dysfunction in 4 cases (4.0%), minor bleeding in 2 cases (2.0%), persistent wound drainage in 3 cases (3.0%), and eruption in 1 case (1.0%). The complications of enoxaparin therapy were persistent wound drainage in 1 case (1.0%) and progression of anemia in 1 case (1.0%). The incidence of VTE was low in patients who selectively received no anticoagulant prophylaxis, so we conclude that anticoagulant prophylaxis should be used selectively in THA cases. |
キーワード | total hip arthroplasty venous thromboembolism anticoagulant prophylaxis complications |
Amo Type | Erratum |
出版物タイトル | Acta Medica Okayama |
発行日 | 2015-10 |
巻 | 69巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 325 |
終了ページ | 325 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 26490031 |
関連URL | http://doi.org/10.18926/AMO/53556 |
JaLCDOI | 10.18926/AMO/53679 |
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フルテキストURL | 69_5_319.pdf |
著者 | Hagiya, Hideharu| Iwamuro, Masaya| Tanaka, Takehiro| Hanayama, Yoshihisa| Otsuka, Fumio| |
抄録 | A 60-year-old woman with rheumatoid arthritis treated with methotrexate for a decade complained of slight epigastric discomfort. A positive cytomegalovirus (CMV) antigenemia test indicated the probability of CMV-related gastrointestinal infection, for which esophagogastroduodenoscopy was performed. Endoscopic findings showed a non-specific duodenal mucosal lesion;however, pathological investigation revealed evidence of CMV duodenitis. There is scarce information on the clinical and pathological features of CMV-related duodenitis, likely due to its low prevalence. CMV infection in the upper gastrointestinal tract should be considered as a differential diagnosis in high-risk individuals, particularly those with symptoms relating to the digestive system. Biopsy examinations are preferable for the definitive diagnosis of CMV gastrointestinal infection, even without specific endoscopic features. |
キーワード | antigenemia cytomegalovirus (CMV) gastrointestinal infection methotrexate opportunistic infection |
Amo Type | Case Report |
出版物タイトル | Acta Medica Okayama |
発行日 | 2015-10 |
巻 | 69巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 319 |
終了ページ | 323 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 26490030 |
Web of Science KeyUT | 000365519600009 |
JaLCDOI | 10.18926/AMO/53678 |
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フルテキストURL | 69_5_313.pdf |
著者 | Narita, Akiko| Seguchi, Jiro| Shiraga, Fumio| |
抄録 | Paecilomyces lilacinus (P. lilacinus) is a rare cause of fungal scleritis. We herein report a case of P. lilacinus-induced scleritis following bleb-associated endophthalmitis after trabeculectomy that was successfully treated with surgical excision of the affected sclera in combination with antifungal medication. An 85-year-old female underwent trabeculectomy of the left eye. A dellen formed in the corneal periphery due to limbal elevation of the filtering bleb and progressed to an infectious corneal ulcer, leading to blebitis. Eight days after the onset of blebitis, the patient was diagnosed with endophthalmitis, which resolved after vitrectomy. The growth of P. lilacinus was identified on swabs of the conjunctiva and the corneal specimen. Scleritis developed after the resolution of the endophthalmitis, and an early excision of the affected sclera, in addition to antifungal medication, resolved it completely. However, the scleritis recurred in a different region of the left eye. After 7 months of antifungal medication, the left eye showed no residual infection. When treating P. lilacinus-induced scleritis, surgical excision of the affected sclera has been shown to be an effective treatment strategy. Nevertheless, it is possible that the infection may recur in another part of the eyeball after the complete resolution of the primary lesion. |
キーワード | Paecilomyces lilacinus scleritis trabeculectomy |
Amo Type | Case Report |
出版物タイトル | Acta Medica Okayama |
発行日 | 2015-10 |
巻 | 69巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 313 |
終了ページ | 318 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 26490029 |
Web of Science KeyUT | 000365519600008 |
JaLCDOI | 10.18926/AMO/53677 |
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フルテキストURL | 69_5_307.pdf |
著者 | Wada, Nozomu| Nouso, Kazuhiro| Kariyama, Kazuya| Wakuta, Akiko| Kishida, Masayuki| Nishimura, Mamoru| Higashi, Toshihiro| |
抄録 | Sarcoidosis is a systemic disease characterized by the formation of non-caseating granulomas in multiple organs. In the diagnosis of sarcoidosis, imaging modalities such as ultrasonography, computed tomography (CT) and magnetic resonance imaging (MRI) are useful;however, there are few reports of MRI imaging using gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB) MRI. A 46-year-old Japanese female with suspected pulmonary sarcoidosis was admitted to our hospital because low-density mottles in the liver were observed incidentally by chest CT. The low-density mottles were not enhanced at the arterial phase or portal phase by abdominal CT and MRI, and decreased uptake was observed in the hepatobiliary phase of Gd-EOB MRI. No hematological disorder was observed except for a slight increase of biliary enzymes. The lesion was diagnosed as liver sarcoidosis by the liver biopsy. Since the patient refused steroid therapy, we prescribed ursodeoxycholic acid (UDCA). 600mg/day. The serum levels of biliary enzymes were normalized and the abdominal CT findings gradually improved after the initiation of UDCA medication. Gd-EOB MRI showed unique hypointense areas in the liver at the hepatobiliary phase, which might be useful in the diagnosis of liver sarcoidosis. |
キーワード | liver sarcoidosis ursodeoxycholic acid (UDCA) gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB) |
Amo Type | Case Report |
出版物タイトル | Acta Medica Okayama |
発行日 | 2015-10 |
巻 | 69巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 307 |
終了ページ | 311 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 26490028 |
Web of Science KeyUT | 000365519600007 |
JaLCDOI | 10.18926/AMO/53676 |
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フルテキストURL | 69_5_301.pdf |
著者 | Seki, Anna| Iwamuro, Masaya| Yoshioka, Masao| Fujii, Nobuharu| Okada, Hiroyuki| Nose, Soichiro| Takata, Katsuyoshi| Yoshino, Tadashi| Yamamoto, Kazuhide| |
抄録 | A 41-year-old woman was diagnosed with duodenal follicular lymphoma. She had no other lesions and was assigned to a "watch and wait" policy. Swelling of the inguinal lymph nodes appeared 45 months later, and rituximab monotherapy resulted in complete remission. However, follicular lymphoma recurred in the stomach, rectum and mesenteric and external iliac lymph nodes 81 months after the therapy. The patient received rituximab monotherapy again and has remained in complete remission in the fifteenth year after the initial diagnosis. This case suggests the usefulness of rituximab monotherapy in the long-term management of intestinal follicular lymphoma. |
キーワード | follicular lymphoma duodenum rituximab |
Amo Type | Case Report |
出版物タイトル | Acta Medica Okayama |
発行日 | 2015-10 |
巻 | 69巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 301 |
終了ページ | 306 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 26490027 |
Web of Science KeyUT | 000365519600006 |
JaLCDOI | 10.18926/AMO/53675 |
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フルテキストURL | 69_5_291.pdf |
著者 | Sugiu, Kumi| Iwamoto, Takayuki| Kelly, Catherine M.| Watanabe, Naoki| Motoki, Takayuki| Itoh, Mitsuya| Ohtani, Shoichiro| Higaki, Kenji| Imada, Takako| Yuasa, Takeshi| Omori, Masako| Sonobe, Hiroshi| Fujiwara, Toshiyoshi| Matsuoka, Junji| |
抄録 | Although in the neoadjuvant setting for estrogen receptor (ER)-positive breast cancers, chemotherapy or hormone therapy alone does not result in satisfactory tumor response, it is unknown whether concurrent chemo-endocrine therapy is superior to chemotherapy alone in clinical outcomes. We conducted a randomized phase II trial to test the responses of ER-positive patients to concurrent administration of chemo-endocrine therapy in the neoadjuvant setting. Women with stage II-III, ER-positive, invasive breast cancer (n=28) received paclitaxel followed by fluorouracil, epirubicin, cyclophosphamide (T-FEC) and were randomized to receive concurrent chemo-endocrine therapy consisting of goserelin administered subcutaneously for premenopausal women or an aromatase inhibitor for postmenopausal women. The primary endpoint was the pathological complete response (pCR) rate after neoadjuvant therapy. Twenty-eight patients were randomized. There were no significant differences in pCR rate between the concurrent group (12.5%;2/16) and the chemotherapy alone group (8.3%;1/12). Tumor size after therapy was significantly reduced in the concurrent therapy group (p=0.035), but not in the chemotherapy-alone group (p=0.622). Neoadjuvant chemotherapy with concurrent hormone therapy provided no significant improvement in pCR rate in ER-positive breast cancers. These preliminary results should be followed up by further studies. |
キーワード | breast cancer neoadjuvant chemotherapy concurrent hormone therapy estrogen receptor positive tumor response |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2015-10 |
巻 | 69巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 291 |
終了ページ | 299 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 26490026 |
Web of Science KeyUT | 000365519600005 |
JaLCDOI | 10.18926/AMO/53674 |
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フルテキストURL | 69_5_279.pdf |
著者 | Saito, Yukie| Fujii, Yousuke| Yashiro, Masato| Tsuge, Mitsuru| Nosaka, Nobuyuki| Yamashita, Nobuko| Yamada, Mutsuko| Tsukahara, Hirokazu| Morishima, Tsuneo| |
抄録 | Lung hyperpermeability affects the development of acute respiratory distress syndrome (ARDS), but therapeutic strategies for the control of microvascular permeability have not been established. We examined the effects of edaravone, dexamethasone, and N-monomethyl-L-arginine (L-NMMA) on permeability changes in human pulmonary microvascular endothelial cells (PMVEC) under a hypercytokinemic state. Human PMVEC were seeded in a Boyden chamber. After monolayer confluence was achieved, the culture media were replaced respectively by culture media containing edaravone, dexamethasone, and L-NMMA. After 24-h incubation, the monolayer was stimulated with tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). Fluorescein-labeled dextran was added. Then the trans-human PMVEC leak was measured. Expressions of vascular endothelial-cadherin (VE-cadherin) and zonula occludens-1 protein (ZO-1) were evaluated using real-time quantitative polymerase chain reaction and immunofluorescence microscopy. The results showed that TNF-α+IL-1β markedly increased pulmonary microvascular permeability. Pretreatment with edaravone, dexamethasone, or L-NMMA attenuated the hyperpermeability and inhibited the cytokine-induced reduction of VE-cadherin expression on immunofluorescence staining. Edaravone and dexamethasone increased the expression of ZO-1 at both the mRNA and protein levels. Edaravone and dexamethasone inhibited the permeability changes of human PMVEC, at least partly through an enhancement of VE-cadherin. Collectively, these results suggest a potential therapeutic approach for intervention in patients with ARDS. |
キーワード | pulmonary microvascular endothelial cells permeability edaravone vascular endothelial-cadherin zonula occludens-1 protein |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2015-10 |
巻 | 69巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 279 |
終了ページ | 290 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 26490025 |
Web of Science KeyUT | 000365519600004 |
JaLCDOI | 10.18926/AMO/53673 |
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フルテキストURL | 69_5_275.pdf |
著者 | Nosaka, Nobuyuki| Goda, Yu| Knaup, Emily| Tsukahara, Kohei| Yumoto, Tetsuya| Ugawa, Toyomu| Ujike, Yoshihito| |
抄録 | We sought to identify the incidence, injury patterns, and financial burden of ladder fall injuries to provide a reference for reinforcing guidelines on the prevention of such injuries. We enrolled the patients who were injured in a ladder-related fall and required intensive care between April 2012 and March 2014 at Okayama University Hospital, a tertiary care hospital in Okayama City:9 patients injured in 7 stepladder falls and 2 straight ladder falls. The median patient age was 69 years, and 8 were males. Six falls occurred in non-occupational settings. Head injuries predominated, and the injury severity score ranged from 2 to 35 (mean=21±12). At the time of discharge from the intensive care unit, one patient had died and 5 patients had some neurological disabilities. The case fatality rate was 11%. The total cost of care during the review period was ¥16,705,794, with a mean cost of ¥1,856,199 per patient. Ladder fall injuries are associated with a high rate of neurological sequelae and pose a financial burden on the health insurance system. A prevention education campaign targeting at older-aged males in non-occupational settings may be a worthwhile health service investment in this community. |
キーワード | accidental falls accident prevention hospital costs injuries ladder |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2015-10 |
巻 | 69巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 275 |
終了ページ | 278 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 26490024 |
Web of Science KeyUT | 000365519600003 |
JaLCDOI | 10.18926/AMO/53672 |
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フルテキストURL | 69_5_267.pdf |
著者 | Inada, Ryo| Nagasaka, Takeshi| Kondo, Yoshitaka| Watanabe, Ayako| Toshima, Toshiaki| Kubota, Nobuhito| Kikuchi, Satoru| Ishida, Michihiro| Kuroda, Shinji| Mori, Yoshiko| Kishimoto, Hiroyuki| Fujiwara, Toshiyoshi| |
抄録 | The aim of this single-institution, retrospective, observational case-control study was to evaluate the safety and feasibility of laparoscopic proctocolectomy (PC) for ulcerative colitis (UC), by comparing it with a case-control series of open PC. Twenty UC patients who underwent laparoscopic PC were retrospectively compared with the open PC group of 12 patients matched for age, sex, and urgency of the operation. In the laparoscopic PC group, the operative time was significantly longer, but the amount of blood loss was significantly smaller. The open PC patients underwent an intraoperative blood transfusion significantly more often, and the serum C-reactive protein level on the first postoperative day was significantly higher in the open PC group. In the laparoscopic PC group, the rate of severe postoperative morbidities, grades 3 and 4 on the Clavien-Dindo classification, was significantly lower, and the median length of hospital stay was significantly shorter. Laparoscopic PC for patients with UC showed superior perioperative outcomes to open PC, except for longer operative time. |
キーワード | laparoscopic surgery total proctocolectomy open proctocolectomy ulcerative colitis case-matched study |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2015-10 |
巻 | 69巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 267 |
終了ページ | 273 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 26490023 |
Web of Science KeyUT | 000365519600002 |
JaLCDOI | 10.18926/AMO/53671 |
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フルテキストURL | 69_5_261.pdf |
著者 | Nojima, Daisuke| Fujimoto, Nobukazu| Kato, Katsuya| Fuchimoto, Yasuko| Kiura, Katsuyuki| Kishimoto, Takumi| Tanimoto, Mitsune| |
抄録 | We investigated the clinical features of asbestos-induced diffuse pleural thickening (DPT) with severe respiratory compromise. We conducted a retrospective study of consecutive subjects with asbestos-induced DPT. Medical data such as initial symptoms, radiological findings, respiratory function test results, and clinical course were collected and analyzed. There were 24 patients between 2003 and 2012. All were men, and the median age at the development of DPT was 74 years. The top occupational category associated with asbestos exposure was dockyard workers. The median duration of asbestos exposure was 35.0 years, and the median latency from first exposure to the onset of DPT was 49.0 years. There were no significant differences in respiratory function test results between the higher and lower Brinkman index groups or between unilateral and bilateral DPT. Thirteen patients had a history of benign asbestos pleural effusion (BAPE), and the median duration from pleural fluid accumulation to DPT with severe respiratory compromise was 28.4 months. DPT with severe respiratory compromise can develop after a long latency following occupational asbestos exposure and a history of BAPE. |
キーワード | asbestos pleural thickening MRC dyspnea scale respiratory function test costophrenic angle |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2015-10 |
巻 | 69巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 261 |
終了ページ | 266 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 26490022 |
Web of Science KeyUT | 000365519600001 |
著者 | Kawata, Tetsuhiro| Matsuo, Toshihiko| Uchida, Tetsuya| |
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発行日 | 2014-06-25 |
出版物タイトル | SpringerPlus |
巻 | 3巻 |
資料タイプ | 学術雑誌論文 |
著者 | Dansako, Hiromichi| Ueda, Youki| Okumura, Nobuaki| Satoh, Shinya| Sugiyama, Masaya| Mizokami, Masashi| Ikeda, Masanori| Kato, Nobuyuki| |
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発行日 | 2015 |
出版物タイトル | The FEBS journal |
資料タイプ | 学術雑誌論文 |
著者 | Rashid Mwajita, Mwashasha| Murage, Hunja| Tani, Akio| Kahangi, Esther M| |
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発行日 | 2013-11-13 |
出版物タイトル | SpringerPlus |
巻 | 2巻 |
資料タイプ | 学術雑誌論文 |
著者 | Onishi, Manabu| Kurozumi, Kazuhiko| Ichikawa, Tomotsugu| Michiue, Hiroyuki| Fujii, Kentaro| Ishida, Joji| Shimazu, Yosuke| Chiocca, E Antonio| Kaur, Balveen| Date, Isao| |
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発行日 | 2013-04-15 |
出版物タイトル | SpringerPlus |
巻 | 2巻 |
資料タイプ | 学術雑誌論文 |