検索結果 - 岡山大学学術成果リポジトリ

Environmental flow sustainability in the Lower Limpopo River Basin, Mozambique

フルテキストURL	fulltext.pdf
著者	Zefanias Nhassengo, Osvaldo Silva\| Somura, Hiroaki\| Wolfe, June III\|
キーワード	Ecosystem sustainability Environmental flow requirement Small scale irrigation Water demand Water scarcity
発行日	2021-08
出版物タイトル	Journal Of Hydrology-Regional Studies
巻	36巻
出版者	Elsevier
開始ページ	100843
ISSN	2214-5818
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 The Author(s).
論文のバージョン	publisher
DOI	10.1016/j.ejrh.2021.100843
Web of Science KeyUT	000687242400006
関連URL	isVersionOf https://doi.org/10.1016/j.ejrh.2021.100843

Meta-Analysis-Assisted Detection of Gravity-Sensitive Genes in Human Vascular Endothelial Cells

フルテキストURL	fulltext.pdf
著者	Liang, Yin\| Wang, Mengxue\| Liu, Yun\| Wang, Chen\| Takahashi, Ken\| Naruse, Keiji\|
キーワード	DNA microarrays meta-analysis microgravity human umbilical vein endothelial cells prostaglandin transporter clinostat spaceflight-associated neuro-ocular syndrome
発行日	2021-08-04
出版物タイトル	Frontiers In Cell and Developmental Biology
巻	9巻
出版者	Frontiers Media SA
開始ページ	689662
ISSN	2296-634X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 Liang, Wang, Liu, Wang, Takahashi and Naruse.
論文のバージョン	publisher
PubMed ID	34422812
DOI	10.3389/fcell.2021.689662
Web of Science KeyUT	000685039800011
関連URL	isVersionOf https://doi.org/10.3389/fcell.2021.689662

Purification, Characterization, and Gene Expression of Rice Endo-beta-N-Acetylglucosaminidase, Endo-Os

フルテキストURL	fulltext.pdf
著者	Maeda, Megumi\| Okamoto, Naoko\| Araki, Node\| Kimura, Yoshinobu\|
キーワード	endo-beta-N-acetylglucosaminidase free N-glycans Oryza sativa ER associated degradation peptide:N-glycanase
発行日	2021-08-10
出版物タイトル	frontiers in Plant Science
巻	12巻
出版者	Frontiers Media SA
開始ページ	647684
ISSN	1664-462X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 Maeda, Okamoto, Araki and Kimura.
論文のバージョン	publisher
DOI	10.3389/fpls.2021.647684
Web of Science KeyUT	000685033400010
関連URL	isVersionOf https://doi.org/10.3389/fpls.2021.647684

Novel urinary glycan profiling by lectin array serves as the biomarkers for predicting renal prognosis in patients with IgA nephropathy

フルテキストURL	fulltext.pdf
著者	Kawakita, Chieko\| Mise, Koki\| Onishi, Yasuhiro\| Sugiyama, Hitoshi\| Yoshida, Michihiro\| Yamada, Masao\| Wada, Jun\|
発行日	2021-02-09
出版物タイトル	Scientific Reports
巻	11巻
号	1号
出版者	Nature Portfolio
開始ページ	3394
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2021
論文のバージョン	publisher
PubMed ID	33564009
DOI	10.1038/s41598-020-77736-1
Web of Science KeyUT	000684869400004
関連URL	isVersionOf https://doi.org/10.1038/s41598-020-77736-1

Single domain growth and charge ordering of epitaxial YbFe2O4 films

フルテキストURL	fulltext20210824-4.pdf
著者	Sakagami, Takumi\| Ota, Reika\| Kano, Jun\| Ikeda, Naoshi\| Fujii, Tatsuo\|
備考	This is an Accepted Manuscript of an article published by Royal Society of Chemistry. This fulltext is available in Aug. 2022.\|
発行日	2021-08-07
出版物タイトル	CrystEngComm
出版者	Royal Society of Chemistry (RSC)
ISSN	1466-8033
NCID	AA12001866
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Royal Society of Chemistry 2021
論文のバージョン	author
DOI	10.1039/d1ce00834j
Web of Science KeyUT	000684549300001
関連URL	isVersionOf https://doi.org/10.1039/d1ce00834j

Association of blood pressure and renal outcome in patients with chronic kidney disease; a post hoc analysis of FROM-J study

フルテキストURL	fulltext.pdf
著者	Tsuchida-Nishiwaki, Mariko\| Uchida, Haruhito A.\| Takeuchi, Hidemi\| Nishiwaki, Noriyuki\| Maeshima, Yohei\| Saito, Chie\| Sugiyama, Hitoshi\| Wada, Jun\| Narita, Ichiei\| Watanabe, Tsuyoshi\| Matsuo, Seiichi\| Makino, Hirofumi\| Hishida, Akira\| Yamagata, Kunihiro\|
発行日	2021-07-22
出版物タイトル	Scientific Reports
巻	11巻
号	1号
出版者	Nature Portfolio
開始ページ	14990
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2021
論文のバージョン	publisher
PubMed ID	34294784
DOI	10.1038/s41598-021-94467-z
Web of Science KeyUT	000682802200023
関連URL	isVersionOf https://doi.org/10.1038/s41598-021-94467-z

RUNX2 Phosphorylation by Tyrosine Kinase ABL Promotes Breast Cancer Invasion (vol 11, 665273, 2021)

フルテキストURL	fulltext.pdf
著者	He, Fang\| Matsumoto, Yoshinori\| Asano, Yosuke\| Yamamura, Yuriko\| Katsuyama, Takayuki\| Rose, Jose La\| Tomonobu, Nahoko\| Komalasari, Ni Luh Gede Yoni\| Sakaguchi, Masakiyo\| Rottapel, Robert\| Wada, Jun\|
キーワード	ABL-Abelson murine leukemia viral oncogene homolog Runx2 (runt-related transcription factor 2) tyrosine phosphorylation invasion
備考	A Corrigendum on RUNX2 Phosphorylation by Tyrosine Kinase ABL Promotes Breast Cancer Invasion By He F, Matsumoto Y, Asano Y, Yamamura Y, Katsuyama T, Rose JL, Tomonobu N, Komalasari NLGY, Sakaguchi M, Rottapel R and Wada J (2021). Front. Oncol. 11:665273. doi: 10.3389/fonc.2021.665273 Erratum for https://ousar.lib.okayama-u.ac.jp/62214\|
発行日	2021-07-20
出版物タイトル	Frontiers In Oncology
巻	11巻
出版者	Frontiers Media SA.
開始ページ	729192
ISSN	2234-943X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 He, Matsumoto, Asano, Yamamura, Katsuyama, Rose,Tomonobu, Komalasari, Sakaguchi, Rottapel and Wada.
論文のバージョン	publisher
PubMed ID	34354958
DOI	10.3389/fonc.2021.729192
Web of Science KeyUT	000680472200001
関連URL	isVersionOf https://doi.org/10.3389/fonc.2021.729192

Microenvironment of mammary fat pads affected the characteristics of the tumors derived from the induced cancer stem cells

フルテキストURL	fulltext.pdf
著者	Abu Quora, Hagar A.\| Zahra, Maram H.\| El-Ghlban, Samah\| Nair, Neha\| Afify, Said M.\| Hassan, Ghmkin\| Nawara, Hend M.\| Sheta, Mona\| Monzur, Sadia\| Fu, Xiaoying\| Osman, Amira\| Seno, Akimasa\| Seno, Masaharu\|
キーワード	Mammary fat pad microenvironment iPSCs CSCs breast cancer
発行日	2021
出版物タイトル	American Journal of Cancer Research
巻	11巻
号	7号
出版者	e-Century Publishing Corp.
開始ページ	3475
終了ページ	3495
ISSN	2156-6976
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	AJCR (c)2021 e-Century Publishing Corp.
論文のバージョン	publisher
PubMed ID	34354856
Web of Science KeyUT	000680048600006

Synthesis and characterization of conductive flexible cellulose carbon nanohorn sheets for human tissue applications

フルテキストURL	fulltext.pdf
著者	Selvam, Karthik Paneer\| Nagahata, Taichi\| Kato, Kosuke\| Koreishi, Mayuko\| Nakamura, Toshiyuki\| Nakamura, Yoshimasa\| Nishikawa, Takeshi\| Satoh, Ayano\| Hayashi, Yasuhiko\|
キーワード	Carbon Nanohorns Cellulose Skin sensitization Composites Bio-compatible
発行日	2021-10-23
出版物タイトル	Biomaterials Research
巻	24巻
号	1号
出版者	Springer Nature
開始ページ	18
ISSN	1226-4601
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s). 2020
論文のバージョン	publisher
PubMed ID	33110624
DOI	10.1186/s40824-020-00194-3
Web of Science KeyUT	000672709800001
関連URL	isVersionOf https://doi.org/10.1186/s40824-020-00194-3

Studying the Applicability of Generative Adversarial Networks on HEp-2 Cell Image Augmentation

フルテキストURL	fulltext.pdf
著者	Anaam, Asaad\| Bu-Omer, Hani M.\| Gofuku, Akio\|
キーワード	Computer architecture Task analysis Microprocessors Generative adversarial networks Biomedical imaging Measurement Feature extraction Computer-aided diagnosis systems (CADs) convolutional neural networks (CNNs) data augmentation data diversity evaluation metrics generative adversarial networks (GANs) HEp-2 cell image classification
発行日	2021
出版物タイトル	IEEE Access
巻	9巻
出版者	IEEE-Inst Electrical Electronics Engineers Inc
開始ページ	98048
終了ページ	98059
ISSN	2169-3536
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2021.
論文のバージョン	publisher
DOI	10.1109/ACCESS.2021.3095391
Web of Science KeyUT	000673198000001
関連URL	isVersionOf https://doi.org/10.1109/ACCESS.2021.3095391

Parieto-Occipital Alpha and Low-Beta EEG Power Reflect Sense of Agency

フルテキストURL	fulltext.pdf
著者	Bu-Omer, Hani M.\| Gofuku, Akio\| Sato, Kenji\| Miyakoshi, Makoto\|
キーワード	sense of agency electroencephalography (EEG) mirror visual feedback virtual reality delayed visual feedback
発行日	2021-06-03
出版物タイトル	Brain Sciences
巻	11巻
号	6号
出版者	MDPI
開始ページ	743
ISSN	2076-3425
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 by the authors.
論文のバージョン	publisher
PubMed ID	34205076
DOI	10.3390/brainsci11060743
Web of Science KeyUT	000665308500001
関連URL	isVersionOf https://doi.org/10.3390/brainsci11060743

Preparation of Absorption-Resistant Hard Tissue Using Dental Pulp-Derived Cells and Honeycomb Tricalcium Phosphate

フルテキストURL	fulltext.pdf
著者	Takabatake, Kiyofumi\| Nakano, Keisuke\| Kawai, Hotaka\| Inada, Yasunori\| Sukegawa, Shintaro\| Shan, Qiusheng\| Fushimi, Shigeko\| Tsujigiwa, Hidetsugu\| Nagatsuka, Hitoshi\|
キーワード	dental pulp mesenchymal stem cells honeycomb TCP matrix formation dentin formation osteodentin
発行日	2021-06-20
出版物タイトル	Materials
巻	14巻
号	12号
出版者	MDPI
開始ページ	3409
ISSN	1996-1944
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 by the authors.
論文のバージョン	publisher
PubMed ID	34202970
DOI	10.3390/ma14123409
Web of Science KeyUT	000666508000001
関連URL	isVersionOf https://doi.org/10.3390/ma14123409

A Case of Metastatic Fumarate Hydratase-Deficient–like Renal Cell Carcinoma Successfully Managed by Ipilimumab plus Nivolumab

JaLCDOI	10.18926/AMO/62237
フルテキストURL	75_3_397.pdf
著者	Sekito, Takanori\| Takamoto, Atsushi\| Kobayashi, Yasuyuki\| Mitsui, Masao\| Watari, Shogo\| Kubota, Risa\| Sadahira, Takuya\| Iwata, Takehiro\| Nishimura, Shingo\| Edamura, Kohei\| Sako, Tomoko\| Araki, Motoo\| Watanabe, Masami\| Watanabe, Toyohiko\| Shibata, Rei\| Ennishi, Daisuke\| Nasu, Yasutomo\|
抄録	We report a 62-year-old male with metastatic fumarate hydratase-deficient renal cell carcinoma (FH-deficient RCC) without fumarate hydratase (FH) mutation (FH-deficient–like RCC). The International Metastatic RCC Database Consortium risk score was intermediate, and immunotherapy with nivolumab and ipilimumab (Ipi/ Nivo) was initiated. Four cycles of Ipi/Nivo and 5 cycles of nivolumab resulted in a complete response of the metastases. Hypophysitis occurred as an immune-related adverse event after four cycles of Ipi/Nivo. The prognosis of patients with FH-deficient RCC is generally poor. Few reports of FH-deficient RCC successfully treated with Ipi/Nivo have been published. Ipi/Nivo can be effective for treating FH-deficient RCC.
キーワード	fumarate hydratase fumarate hydratase-deficient renal cell carcinoma renal cell carcinoma ipilimumab nivolumab
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2021-06
巻	75巻
号	3号
出版者	Okayama University Medical School
開始ページ	397
終了ページ	402
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34176946
Web of Science KeyUT	000667147700017
NAID	120007089822

Embedding of Epiretinal Proliferation for a Secondary Lamellar Macular Hole 12 Years after Rhegmatogenous Retinal Detachment Repair

JaLCDOI	10.18926/AMO/62236
フルテキストURL	75_3_391.pdf
著者	Fujiwara, Miyuki\| Kimura, Shuhei\| Morizane Hosokawa, Mio\| Shiode, Yusuke\| Doi, Shinichiro\| Takahashi, Kosuke\| Matoba, Ryo\| Kanzaki, Yuki \| Morizane, Yuki\|
抄録	A 58-year-old Japanese man underwent vitrectomy for rhegmatogenous retinal detachment (RRD) in 2002. Twelve years later, optical coherence tomography revealed the development of a lamellar macular hole; the visual acuity was 20/200. Two years later, because metamorphopsia and the foveal retina thinning were aggravated, epiretinal proliferation embedding was performed to restore the foveal structure by transplanting glial cells to the foveal cavity. The patient was followed-up for 4 years, and his macular morphology and visual acuity (20/66) improved. No complications occurred. This appears to be the first report of epiretinal proliferation embedding for a lamellar macular hole post-RRD repair.
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2021-06
巻	75巻
号	3号
出版者	Okayama University Medical School
開始ページ	391
終了ページ	395
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34176945
Web of Science KeyUT	000667147700016
NAID	120007089821

Successful Surgical Management of Acute Appendicitis in a Centenarian

JaLCDOI	10.18926/AMO/62235
フルテキストURL	75_3_385.pdf
著者	Okita, Atsushi\| Fujimura, Masaki\| Sato, Isao\| Chino, Yoshihide\| Yuba, Takafumi\| Mizutani, Makoto\| Tabata, Tomotake\| Iida, Minoru\| Kumano, Kimitsuka\|
Amo Type	Case Report
備考	We report an extremely rare case of a centenarian with acute appendicitis that was successfully managed via emergent surgery. A 109-year-old woman was referred to Daiichi Towakai Hospital with a high fever and nausea. She presented with peritoneal irritation, and computed tomography showed a swollen appendix with intraluminal fecolith. She was diagnosed with acute appendicitis and underwent appendectomy, which was performed via an open approach under spinal anesthesia. The patient’s postoperative course was uneventful. As for treatment planning for centenarians, comprehensive and exhaustive discussions with the patient and family members should be encouraged under the principals of narrative medicine.\|
出版物タイトル	Acta Medica Okayama
発行日	2021-06
巻	75巻
号	3号
出版者	Okayama University Medical School
開始ページ	385
終了ページ	389
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34176944
Web of Science KeyUT	000667147700015
NAID	120007089820

Presence of Microplastics in Four Types of Shellfish Purchased at Fish Markets in Okayama City, Japan

JaLCDOI	10.18926/AMO/62234
フルテキストURL	75_3_381.pdf
著者	Yamamoto, Ken-ichi\| Oshiki, Toshiyuki\| Kagawa, Hiroko\| Namba, Masayoshi\| Sakaguchi, Masakiyo\|
抄録	The worldwide microplastic pollution in our environment is a matter of great concern. Harmful effects of plastics have been reported in various types of organisms including murine animals. We examined the presence of microplastics in four types of shellfish purchased from fish markets in Okayama, Japan and served to the public: short-neck clam (Ruditapes philippinarum, asari in Japanese), hard-shell clam (Meretrix lusoria, hamaguri), brackishwater clam (Cyrenidae, shijimi), and oyster (Crassostrea gigas, kaki). Our analyses demonstrated that approx. 3 pieces of microplastics were present per single shellfish, based on the division of the total number of pieces of microplastic obtained from all 4 types of shellfish by the total number of shellfish examined. Since health problems in humans due to microplastics have not yet been confirmed, further examinations of the effects of ingested microplastics are needed.
キーワード	microplastics, shellfish Japan health effect pollution
Amo Type	Short Communication
出版物タイトル	Acta Medica Okayama
発行日	2021-06
巻	75巻
号	3号
出版者	Okayama University Medical School
開始ページ	381
終了ページ	384
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34176943
Web of Science KeyUT	000667147700014
NAID	120007089831

Relationships among Bone Metabolic Markers, Body Fat Composition and Carotid Intima–Media Thickness in Premenopausal Obese Women

JaLCDOI	10.18926/AMO/62233
フルテキストURL	75_3_373.pdf
著者	Yaylali, Guzin F.\| Dedeoglu, Ozen \| Topsakal, Senay\| Herek, Duygu\| Senol, Hande\|
抄録	Osteocalcin (OC) is inversely related to body fat distribution and fasting glucose levels. We sought to observe the effect of OC on fat distribution and subclinical atherosclerosis as measured by carotid intima-media thickness (CIMT) in premenopausal obese women. In this prospective observational study, totally, 73 premenopausal obese women (aged 17-55 years) and 53 healthy women (aged 20-50 years) with normal weight were included as controls. Anthropometric measurements, total fat and fat ratio, insulin, fasting blood glucose, and OC levels were estimated. Ultrasonography was used to assess fat distribution, and fat thickness was measured in 4 regions. Subcutaneous fat (SCF), visceral fat (VF), and preperitoneal fat (PPF) thicknesses were considerably higher in obese subjects (p<0.01) than healthy controls, while OC levels were significantly lower. No correlation was observed between OC levels and SCF, VF, or PPF. In a multiple regression analysis, OC was significantly positively associated with SCF (p=0.04, Beta=0.284). No associations were observed between OC levels and VF, PPF, or CIMT. A significant association was observed between parathyroid hormone (PTH) and VF (p=0.021, Beta=0.284), and vitamin D levels were inversely associated with VF (p=0.002, r=−0.366). OC levels were lower in premenopausal obese women than normal-weight healthy controls, but OC exhibited no correlation with VF or PPF, and only a weak positive association with SCF. Additionally, VF was positively correlated with PTH and inversely correlated with vitamin D. These results suggest that OC may be an early indicator of lipid accumulation in te subcutaneous area and development of atherosclerosis.
キーワード	body fat composition carotid intima-media thickness obesity osteocalcin premenopausal women
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-06
巻	75巻
号	3号
出版者	Okayama University Medical School
開始ページ	373
終了ページ	379
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34176942
Web of Science KeyUT	000667147700013
NAID	120007089830

Role of the Transcription Factor BTB and CNC Homology 1 in a Rat Model of Acute Liver Injury Induced by Experimental Endotoxemia

JaLCDOI	10.18926/AMO/62232
フルテキストURL	75_3_363.pdf
著者	Tanioka, Nohito\| Shimizu, Hiroko\| Omori, Emiko\| Takahashi, Toru\| Yamaoka, Masakazu\| Morimatsu, Hiroshi\|
抄録	Hepatic oxidative stress plays an important role in the pathogenesis of several acute liver diseases, and free heme is thought to contribute to endotoxemia-induced acute liver injury. The heme oxygenase 1 (HO-1) gene is upregulated and the δ-aminolevulinate synthase (ALAS1) gene is downregulated in the rat liver following lipopolysaccharide (LPS) treatment. BTB and CNC homology 1 (Bach1) is a heme-responsive transcription factor that normally represses HO-1 expression. In this study, we evaluated the changes in HO-1, ALAS1, and Bach1 expression and nuclear Bach1 expression in rat livers following intravenous LPS administration (10 mg/kg body weight). LPS significantly upregulated HO-1 mRNA and downregulated ALAS1 mRNA in the rat livers, suggesting that hepatic free heme concentrations are increased after LPS treatment. Bach1 mRNA was strongly induced after LPS injection. In contrast, nuclear Bach1 was significantly but transiently decreased after LPS treatment. Rats were also administered hemin (50 mg/kg body weight) intravenously to elevate heme concentrations, which decreased nuclear Bach1 levels. Our results suggest that elevated hepatic free heme may be associated with a decline of nuclear Bach1, and induction of Bach1 mRNA may compensate for the decreased nuclear Bach1 after LPS treatment in the rat liver.
キーワード	heme oxygenase-1 BTB and CNC homology 1 heme, lipopolysaccharide liver injury
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-06
巻	75巻
号	3号
出版者	Okayama University Medical School
開始ページ	363
終了ページ	372
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34176941
Web of Science KeyUT	000667147700012
NAID	120007089829

Optimizing the timing of 3.6 mg Pegfilgrastim Administration for Dose-Dense Chemotherapy in Japanese Patients with Breast Cancer

JaLCDOI	10.18926/AMO/62231
フルテキストURL	75_3_357.pdf
著者	Takabatake, Daisuke\| Kajiwara, Yukiko\| Ohtani, Shoichiro\| Suzuki, Yoko\| Yamamoto, Mari\| Kubo, Shinichiro\| Ikeda, Masahiko\| Takahashi, Mina\| Hara, Fumikata\| Aogi, Kenjiro\| Ohsumi, Shozo\| Ogasawara, Yutaka\| Nishiyama, Yoshitaka\| Hikino, Hajime\| Matsuoka, Kinya\| Shien, Tadahiko\| Taira, Naruto\| Doihara, Hiroyoshi\|
抄録	Perioperative dose-dense chemotherapy (DDCT) with pegfilgrastim (Peg) prophylaxis is a standard treatment for high-risk breast cancer. We explored the optimal timing of administration of 3.6 mg Peg, the dose approved in Japan. In the phase II feasibility study of DDCT (adriamycin+cyclophosphamide or epirubicin+cyclophosphamide followed by paclitaxel) for breast cancer, we investigated the feasibility, safety, neutrophil transition, and optimal timing of Peg treatment by administering Peg at days 2, 3, and 4 post-chemotherapy (P2, P3, and P4 groups, respectively). Among the 52 women enrolled, 13 were aged > 60 years. The anthracycline sequence was administered to P2 (n=33), P3 (n=5), and P4 (n=14) patients, and the taxane sequence to P2 (n=38) and P3 (n=6) patients. Both sequences showed no interaction between Peg administration timing and treatment discontinuation, treatment delay, or dose reduction. However, the relative dose intensity (RDI) was significantly different among the groups. The neutrophil count transition differed significantly among the groups receiving the anthracycline sequence. However, the neutrophil count remained in the appropriate range for both sequences in the P2 group. The timing of Peg administration did not substantially affect the feasibility or safety of DDCT. Postoperative day 2 might be the optimal timing for DDCT.
キーワード	dose-dense chemotherapy breast cancer pegfilgrastim
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-06
巻	75巻
号	3号
出版者	Okayama University Medical School
開始ページ	357
終了ページ	362
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34176940
Web of Science KeyUT	000667147700011
NAID	120007089828

Texture Indices of 18F-FDG PET/CT for Differentiating Squamous Cell Carcinoma and Non-Hodgkin’s Lymphoma of the Oropharynx

JaLCDOI	10.18926/AMO/62230
フルテキストURL	75_3_351.pdf
著者	Mitamura, Katsuya\| Norikane, Takashi\| Yamamoto, Yuka\| Ihara-Nishishita, Ayumi\| Kobata, Takuya\| Fujimoto, Kengo\| Takami, Yasukage\| Kudomi, Nobuyuki\| Hoshikawa, Hiroshi\| Nishiyama, Yoshihiro\|
抄録	We assessed the role of 18F-FDG PET/CT texture indices for the differentiation of squamous cell carcinoma (SCC) and non-Hodgkin’s lymphoma (NHL) in the oropharynx. 18F-FDG PET/CT data for 27 patients with SCC and 25 patients with NHL in the oropharynx were investigated. The maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and six texture indices (homogeneity, entropy, short-run emphasis, long-run emphasis, low gray-level zone emphasis [LGZE], and high graylevel zone emphasis [HGZE]) were derived from PET images. PET/CT parameters of the SCC patients were compared with those of the NHL patients. The diagnostic accuracy of the indices for differentiating SCC from NHL was calculated by a receiver operating characteristic curve analysis. 18F-FDG uptake in the oropharynx was observed in all of the patients. The SUVmax, MTV, and TLG did not differ significantly between the SCC and NHL groups, but two of the six texture indices (LGZE [p=0.004] and HGZE [p=0.03]) showed significant differences between the groups. LGZE was the best discriminative index for the differentiation of SCC and NHL (55.6% sensitivity, 88.0% specificity). The LGZE and HGZE texture indices derived from 18F-FDG PET/CT images may be useful in differentiating SCC and NHL in the oropharynx.
キーワード	18F-FDG PET/CT oropharyngeal squamous cell carcinoma malignant lymphoma texture
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-06
巻	75巻
号	3号
出版者	Okayama University Medical School
開始ページ	351
終了ページ	356
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34176939
Web of Science KeyUT	000667147700010
NAID	120007089827