result 3430 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Zefanias Nhassengo, Osvaldo Silva| Somura, Hiroaki| Wolfe, June III| |
| Keywords | Ecosystem sustainability Environmental flow requirement Small scale irrigation Water demand Water scarcity |
| Published Date | 2021-08 |
| Publication Title | Journal Of Hydrology-Regional Studies |
| Volume | volume36 |
| Publisher | Elsevier |
| Start Page | 100843 |
| ISSN | 2214-5818 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 The Author(s). |
| File Version | publisher |
| DOI | 10.1016/j.ejrh.2021.100843 |
| Web of Science KeyUT | 000687242400006 |
| Related Url | isVersionOf https://doi.org/10.1016/j.ejrh.2021.100843 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Liang, Yin| Wang, Mengxue| Liu, Yun| Wang, Chen| Takahashi, Ken| Naruse, Keiji| |
| Keywords | DNA microarrays meta-analysis microgravity human umbilical vein endothelial cells prostaglandin transporter clinostat spaceflight-associated neuro-ocular syndrome |
| Published Date | 2021-08-04 |
| Publication Title | Frontiers In Cell and Developmental Biology |
| Volume | volume9 |
| Publisher | Frontiers Media SA |
| Start Page | 689662 |
| ISSN | 2296-634X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 Liang, Wang, Liu, Wang, Takahashi and Naruse. |
| File Version | publisher |
| PubMed ID | 34422812 |
| DOI | 10.3389/fcell.2021.689662 |
| Web of Science KeyUT | 000685039800011 |
| Related Url | isVersionOf https://doi.org/10.3389/fcell.2021.689662 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Maeda, Megumi| Okamoto, Naoko| Araki, Node| Kimura, Yoshinobu| |
| Keywords | endo-beta-N-acetylglucosaminidase free N-glycans Oryza sativa ER associated degradation peptide:N-glycanase |
| Published Date | 2021-08-10 |
| Publication Title | frontiers in Plant Science |
| Volume | volume12 |
| Publisher | Frontiers Media SA |
| Start Page | 647684 |
| ISSN | 1664-462X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 Maeda, Okamoto, Araki and Kimura. |
| File Version | publisher |
| DOI | 10.3389/fpls.2021.647684 |
| Web of Science KeyUT | 000685033400010 |
| Related Url | isVersionOf https://doi.org/10.3389/fpls.2021.647684 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kawakita, Chieko| Mise, Koki| Onishi, Yasuhiro| Sugiyama, Hitoshi| Yoshida, Michihiro| Yamada, Masao| Wada, Jun| |
| Published Date | 2021-02-09 |
| Publication Title | Scientific Reports |
| Volume | volume11 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 3394 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2021 |
| File Version | publisher |
| PubMed ID | 33564009 |
| DOI | 10.1038/s41598-020-77736-1 |
| Web of Science KeyUT | 000684869400004 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-020-77736-1 |
| FullText URL | fulltext20210824-4.pdf |
|---|---|
| Author | Sakagami, Takumi| Ota, Reika| Kano, Jun| Ikeda, Naoshi| Fujii, Tatsuo| |
| Note | This is an Accepted Manuscript of an article published by Royal Society of Chemistry. This fulltext is available in Aug. 2022.| |
| Published Date | 2021-08-07 |
| Publication Title | CrystEngComm |
| Publisher | Royal Society of Chemistry (RSC) |
| ISSN | 1466-8033 |
| NCID | AA12001866 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Royal Society of Chemistry 2021 |
| File Version | author |
| DOI | 10.1039/d1ce00834j |
| Web of Science KeyUT | 000684549300001 |
| Related Url | isVersionOf https://doi.org/10.1039/d1ce00834j |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tsuchida-Nishiwaki, Mariko| Uchida, Haruhito A.| Takeuchi, Hidemi| Nishiwaki, Noriyuki| Maeshima, Yohei| Saito, Chie| Sugiyama, Hitoshi| Wada, Jun| Narita, Ichiei| Watanabe, Tsuyoshi| Matsuo, Seiichi| Makino, Hirofumi| Hishida, Akira| Yamagata, Kunihiro| |
| Published Date | 2021-07-22 |
| Publication Title | Scientific Reports |
| Volume | volume11 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 14990 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2021 |
| File Version | publisher |
| PubMed ID | 34294784 |
| DOI | 10.1038/s41598-021-94467-z |
| Web of Science KeyUT | 000682802200023 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-021-94467-z |
| FullText URL | fulltext.pdf |
|---|---|
| Author | He, Fang| Matsumoto, Yoshinori| Asano, Yosuke| Yamamura, Yuriko| Katsuyama, Takayuki| Rose, Jose La| Tomonobu, Nahoko| Komalasari, Ni Luh Gede Yoni| Sakaguchi, Masakiyo| Rottapel, Robert| Wada, Jun| |
| Keywords | ABL-Abelson murine leukemia viral oncogene homolog Runx2 (runt-related transcription factor 2) tyrosine phosphorylation invasion |
| Note | A Corrigendum on RUNX2 Phosphorylation by Tyrosine Kinase ABL Promotes Breast Cancer Invasion By He F, Matsumoto Y, Asano Y, Yamamura Y, Katsuyama T, Rose JL, Tomonobu N, Komalasari NLGY, Sakaguchi M, Rottapel R and Wada J (2021). Front. Oncol. 11:665273. doi: 10.3389/fonc.2021.665273 Erratum for https://ousar.lib.okayama-u.ac.jp/62214| |
| Published Date | 2021-07-20 |
| Publication Title | Frontiers In Oncology |
| Volume | volume11 |
| Publisher | Frontiers Media SA. |
| Start Page | 729192 |
| ISSN | 2234-943X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 He, Matsumoto, Asano, Yamamura, Katsuyama, Rose,Tomonobu, Komalasari, Sakaguchi, Rottapel and Wada. |
| File Version | publisher |
| PubMed ID | 34354958 |
| DOI | 10.3389/fonc.2021.729192 |
| Web of Science KeyUT | 000680472200001 |
| Related Url | isVersionOf https://doi.org/10.3389/fonc.2021.729192 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Abu Quora, Hagar A.| Zahra, Maram H.| El-Ghlban, Samah| Nair, Neha| Afify, Said M.| Hassan, Ghmkin| Nawara, Hend M.| Sheta, Mona| Monzur, Sadia| Fu, Xiaoying| Osman, Amira| Seno, Akimasa| Seno, Masaharu| |
| Keywords | Mammary fat pad microenvironment iPSCs CSCs breast cancer |
| Published Date | 2021 |
| Publication Title | American Journal of Cancer Research |
| Volume | volume11 |
| Issue | issue7 |
| Publisher | e-Century Publishing Corp. |
| Start Page | 3475 |
| End Page | 3495 |
| ISSN | 2156-6976 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | AJCR (c)2021 e-Century Publishing Corp. |
| File Version | publisher |
| PubMed ID | 34354856 |
| Web of Science KeyUT | 000680048600006 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Selvam, Karthik Paneer| Nagahata, Taichi| Kato, Kosuke| Koreishi, Mayuko| Nakamura, Toshiyuki| Nakamura, Yoshimasa| Nishikawa, Takeshi| Satoh, Ayano| Hayashi, Yasuhiko| |
| Keywords | Carbon Nanohorns Cellulose Skin sensitization Composites Bio-compatible |
| Published Date | 2021-10-23 |
| Publication Title | Biomaterials Research |
| Volume | volume24 |
| Issue | issue1 |
| Publisher | Springer Nature |
| Start Page | 18 |
| ISSN | 1226-4601 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s). 2020 |
| File Version | publisher |
| PubMed ID | 33110624 |
| DOI | 10.1186/s40824-020-00194-3 |
| Web of Science KeyUT | 000672709800001 |
| Related Url | isVersionOf https://doi.org/10.1186/s40824-020-00194-3 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Anaam, Asaad| Bu-Omer, Hani M.| Gofuku, Akio| |
| Keywords | Computer architecture Task analysis Microprocessors Generative adversarial networks Biomedical imaging Measurement Feature extraction Computer-aided diagnosis systems (CADs) convolutional neural networks (CNNs) data augmentation data diversity evaluation metrics generative adversarial networks (GANs) HEp-2 cell image classification |
| Published Date | 2021 |
| Publication Title | IEEE Access |
| Volume | volume9 |
| Publisher | IEEE-Inst Electrical Electronics Engineers Inc |
| Start Page | 98048 |
| End Page | 98059 |
| ISSN | 2169-3536 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2021. |
| File Version | publisher |
| DOI | 10.1109/ACCESS.2021.3095391 |
| Web of Science KeyUT | 000673198000001 |
| Related Url | isVersionOf https://doi.org/10.1109/ACCESS.2021.3095391 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Bu-Omer, Hani M.| Gofuku, Akio| Sato, Kenji| Miyakoshi, Makoto| |
| Keywords | sense of agency electroencephalography (EEG) mirror visual feedback virtual reality delayed visual feedback |
| Published Date | 2021-06-03 |
| Publication Title | Brain Sciences |
| Volume | volume11 |
| Issue | issue6 |
| Publisher | MDPI |
| Start Page | 743 |
| ISSN | 2076-3425 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 by the authors. |
| File Version | publisher |
| PubMed ID | 34205076 |
| DOI | 10.3390/brainsci11060743 |
| Web of Science KeyUT | 000665308500001 |
| Related Url | isVersionOf https://doi.org/10.3390/brainsci11060743 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Takabatake, Kiyofumi| Nakano, Keisuke| Kawai, Hotaka| Inada, Yasunori| Sukegawa, Shintaro| Shan, Qiusheng| Fushimi, Shigeko| Tsujigiwa, Hidetsugu| Nagatsuka, Hitoshi| |
| Keywords | dental pulp mesenchymal stem cells honeycomb TCP matrix formation dentin formation osteodentin |
| Published Date | 2021-06-20 |
| Publication Title | Materials |
| Volume | volume14 |
| Issue | issue12 |
| Publisher | MDPI |
| Start Page | 3409 |
| ISSN | 1996-1944 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 by the authors. |
| File Version | publisher |
| PubMed ID | 34202970 |
| DOI | 10.3390/ma14123409 |
| Web of Science KeyUT | 000666508000001 |
| Related Url | isVersionOf https://doi.org/10.3390/ma14123409 |
| JaLCDOI | 10.18926/AMO/62237 |
|---|---|
| FullText URL | 75_3_397.pdf |
| Author | Sekito, Takanori| Takamoto, Atsushi| Kobayashi, Yasuyuki| Mitsui, Masao| Watari, Shogo| Kubota, Risa| Sadahira, Takuya| Iwata, Takehiro| Nishimura, Shingo| Edamura, Kohei| Sako, Tomoko| Araki, Motoo| Watanabe, Masami| Watanabe, Toyohiko| Shibata, Rei| Ennishi, Daisuke| Nasu, Yasutomo| |
| Abstract | We report a 62-year-old male with metastatic fumarate hydratase-deficient renal cell carcinoma (FH-deficient RCC) without fumarate hydratase (FH) mutation (FH-deficient–like RCC). The International Metastatic RCC Database Consortium risk score was intermediate, and immunotherapy with nivolumab and ipilimumab (Ipi/ Nivo) was initiated. Four cycles of Ipi/Nivo and 5 cycles of nivolumab resulted in a complete response of the metastases. Hypophysitis occurred as an immune-related adverse event after four cycles of Ipi/Nivo. The prognosis of patients with FH-deficient RCC is generally poor. Few reports of FH-deficient RCC successfully treated with Ipi/Nivo have been published. Ipi/Nivo can be effective for treating FH-deficient RCC. |
| Keywords | fumarate hydratase fumarate hydratase-deficient renal cell carcinoma renal cell carcinoma ipilimumab nivolumab |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 397 |
| End Page | 402 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176946 |
| Web of Science KeyUT | 000667147700017 |
| NAID | 120007089822 |
| JaLCDOI | 10.18926/AMO/62236 |
|---|---|
| FullText URL | 75_3_391.pdf |
| Author | Fujiwara, Miyuki| Kimura, Shuhei| Morizane Hosokawa, Mio| Shiode, Yusuke| Doi, Shinichiro| Takahashi, Kosuke| Matoba, Ryo| Kanzaki, Yuki | Morizane, Yuki| |
| Abstract | A 58-year-old Japanese man underwent vitrectomy for rhegmatogenous retinal detachment (RRD) in 2002. Twelve years later, optical coherence tomography revealed the development of a lamellar macular hole; the visual acuity was 20/200. Two years later, because metamorphopsia and the foveal retina thinning were aggravated, epiretinal proliferation embedding was performed to restore the foveal structure by transplanting glial cells to the foveal cavity. The patient was followed-up for 4 years, and his macular morphology and visual acuity (20/66) improved. No complications occurred. This appears to be the first report of epiretinal proliferation embedding for a lamellar macular hole post-RRD repair. |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 391 |
| End Page | 395 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176945 |
| Web of Science KeyUT | 000667147700016 |
| NAID | 120007089821 |
| JaLCDOI | 10.18926/AMO/62235 |
|---|---|
| FullText URL | 75_3_385.pdf |
| Author | Okita, Atsushi| Fujimura, Masaki| Sato, Isao| Chino, Yoshihide| Yuba, Takafumi| Mizutani, Makoto| Tabata, Tomotake| Iida, Minoru| Kumano, Kimitsuka| |
| Amo Type | Case Report |
| Note | We report an extremely rare case of a centenarian with acute appendicitis that was successfully managed via emergent surgery. A 109-year-old woman was referred to Daiichi Towakai Hospital with a high fever and nausea. She presented with peritoneal irritation, and computed tomography showed a swollen appendix with intraluminal fecolith. She was diagnosed with acute appendicitis and underwent appendectomy, which was performed via an open approach under spinal anesthesia. The patient’s postoperative course was uneventful. As for treatment planning for centenarians, comprehensive and exhaustive discussions with the patient and family members should be encouraged under the principals of narrative medicine.| |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 385 |
| End Page | 389 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176944 |
| Web of Science KeyUT | 000667147700015 |
| NAID | 120007089820 |
| JaLCDOI | 10.18926/AMO/62234 |
|---|---|
| FullText URL | 75_3_381.pdf |
| Author | Yamamoto, Ken-ichi| Oshiki, Toshiyuki| Kagawa, Hiroko| Namba, Masayoshi| Sakaguchi, Masakiyo| |
| Abstract | The worldwide microplastic pollution in our environment is a matter of great concern. Harmful effects of plastics have been reported in various types of organisms including murine animals. We examined the presence of microplastics in four types of shellfish purchased from fish markets in Okayama, Japan and served to the public: short-neck clam (Ruditapes philippinarum, asari in Japanese), hard-shell clam (Meretrix lusoria, hamaguri), brackishwater clam (Cyrenidae, shijimi), and oyster (Crassostrea gigas, kaki). Our analyses demonstrated that approx. 3 pieces of microplastics were present per single shellfish, based on the division of the total number of pieces of microplastic obtained from all 4 types of shellfish by the total number of shellfish examined. Since health problems in humans due to microplastics have not yet been confirmed, further examinations of the effects of ingested microplastics are needed. |
| Keywords | microplastics, shellfish Japan health effect pollution |
| Amo Type | Short Communication |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 381 |
| End Page | 384 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176943 |
| Web of Science KeyUT | 000667147700014 |
| NAID | 120007089831 |
| JaLCDOI | 10.18926/AMO/62233 |
|---|---|
| FullText URL | 75_3_373.pdf |
| Author | Yaylali, Guzin F.| Dedeoglu, Ozen | Topsakal, Senay| Herek, Duygu| Senol, Hande| |
| Abstract | Osteocalcin (OC) is inversely related to body fat distribution and fasting glucose levels. We sought to observe the effect of OC on fat distribution and subclinical atherosclerosis as measured by carotid intima-media thickness (CIMT) in premenopausal obese women. In this prospective observational study, totally, 73 premenopausal obese women (aged 17-55 years) and 53 healthy women (aged 20-50 years) with normal weight were included as controls. Anthropometric measurements, total fat and fat ratio, insulin, fasting blood glucose, and OC levels were estimated. Ultrasonography was used to assess fat distribution, and fat thickness was measured in 4 regions. Subcutaneous fat (SCF), visceral fat (VF), and preperitoneal fat (PPF) thicknesses were considerably higher in obese subjects (p<0.01) than healthy controls, while OC levels were significantly lower. No correlation was observed between OC levels and SCF, VF, or PPF. In a multiple regression analysis, OC was significantly positively associated with SCF (p=0.04, Beta=0.284). No associations were observed between OC levels and VF, PPF, or CIMT. A significant association was observed between parathyroid hormone (PTH) and VF (p=0.021, Beta=0.284), and vitamin D levels were inversely associated with VF (p=0.002, r=−0.366). OC levels were lower in premenopausal obese women than normal-weight healthy controls, but OC exhibited no correlation with VF or PPF, and only a weak positive association with SCF. Additionally, VF was positively correlated with PTH and inversely correlated with vitamin D. These results suggest that OC may be an early indicator of lipid accumulation in te subcutaneous area and development of atherosclerosis. |
| Keywords | body fat composition carotid intima-media thickness obesity osteocalcin premenopausal women |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 373 |
| End Page | 379 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176942 |
| Web of Science KeyUT | 000667147700013 |
| NAID | 120007089830 |
| JaLCDOI | 10.18926/AMO/62232 |
|---|---|
| FullText URL | 75_3_363.pdf |
| Author | Tanioka, Nohito| Shimizu, Hiroko| Omori, Emiko| Takahashi, Toru| Yamaoka, Masakazu| Morimatsu, Hiroshi| |
| Abstract | Hepatic oxidative stress plays an important role in the pathogenesis of several acute liver diseases, and free heme is thought to contribute to endotoxemia-induced acute liver injury. The heme oxygenase 1 (HO-1) gene is upregulated and the δ-aminolevulinate synthase (ALAS1) gene is downregulated in the rat liver following lipopolysaccharide (LPS) treatment. BTB and CNC homology 1 (Bach1) is a heme-responsive transcription factor that normally represses HO-1 expression. In this study, we evaluated the changes in HO-1, ALAS1, and Bach1 expression and nuclear Bach1 expression in rat livers following intravenous LPS administration (10 mg/kg body weight). LPS significantly upregulated HO-1 mRNA and downregulated ALAS1 mRNA in the rat livers, suggesting that hepatic free heme concentrations are increased after LPS treatment. Bach1 mRNA was strongly induced after LPS injection. In contrast, nuclear Bach1 was significantly but transiently decreased after LPS treatment. Rats were also administered hemin (50 mg/kg body weight) intravenously to elevate heme concentrations, which decreased nuclear Bach1 levels. Our results suggest that elevated hepatic free heme may be associated with a decline of nuclear Bach1, and induction of Bach1 mRNA may compensate for the decreased nuclear Bach1 after LPS treatment in the rat liver. |
| Keywords | heme oxygenase-1 BTB and CNC homology 1 heme, lipopolysaccharide liver injury |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 363 |
| End Page | 372 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176941 |
| Web of Science KeyUT | 000667147700012 |
| NAID | 120007089829 |
| JaLCDOI | 10.18926/AMO/62231 |
|---|---|
| FullText URL | 75_3_357.pdf |
| Author | Takabatake, Daisuke| Kajiwara, Yukiko| Ohtani, Shoichiro| Suzuki, Yoko| Yamamoto, Mari| Kubo, Shinichiro| Ikeda, Masahiko| Takahashi, Mina| Hara, Fumikata| Aogi, Kenjiro| Ohsumi, Shozo| Ogasawara, Yutaka| Nishiyama, Yoshitaka| Hikino, Hajime| Matsuoka, Kinya| Shien, Tadahiko| Taira, Naruto| Doihara, Hiroyoshi| |
| Abstract | Perioperative dose-dense chemotherapy (DDCT) with pegfilgrastim (Peg) prophylaxis is a standard treatment for high-risk breast cancer. We explored the optimal timing of administration of 3.6 mg Peg, the dose approved in Japan. In the phase II feasibility study of DDCT (adriamycin+cyclophosphamide or epirubicin+cyclophosphamide followed by paclitaxel) for breast cancer, we investigated the feasibility, safety, neutrophil transition, and optimal timing of Peg treatment by administering Peg at days 2, 3, and 4 post-chemotherapy (P2, P3, and P4 groups, respectively). Among the 52 women enrolled, 13 were aged > 60 years. The anthracycline sequence was administered to P2 (n=33), P3 (n=5), and P4 (n=14) patients, and the taxane sequence to P2 (n=38) and P3 (n=6) patients. Both sequences showed no interaction between Peg administration timing and treatment discontinuation, treatment delay, or dose reduction. However, the relative dose intensity (RDI) was significantly different among the groups. The neutrophil count transition differed significantly among the groups receiving the anthracycline sequence. However, the neutrophil count remained in the appropriate range for both sequences in the P2 group. The timing of Peg administration did not substantially affect the feasibility or safety of DDCT. Postoperative day 2 might be the optimal timing for DDCT. |
| Keywords | dose-dense chemotherapy breast cancer pegfilgrastim |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 357 |
| End Page | 362 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176940 |
| Web of Science KeyUT | 000667147700011 |
| NAID | 120007089828 |
| JaLCDOI | 10.18926/AMO/62230 |
|---|---|
| FullText URL | 75_3_351.pdf |
| Author | Mitamura, Katsuya| Norikane, Takashi| Yamamoto, Yuka| Ihara-Nishishita, Ayumi| Kobata, Takuya| Fujimoto, Kengo| Takami, Yasukage| Kudomi, Nobuyuki| Hoshikawa, Hiroshi| Nishiyama, Yoshihiro| |
| Abstract | We assessed the role of 18F-FDG PET/CT texture indices for the differentiation of squamous cell carcinoma (SCC) and non-Hodgkin’s lymphoma (NHL) in the oropharynx. 18F-FDG PET/CT data for 27 patients with SCC and 25 patients with NHL in the oropharynx were investigated. The maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and six texture indices (homogeneity, entropy, short-run emphasis, long-run emphasis, low gray-level zone emphasis [LGZE], and high graylevel zone emphasis [HGZE]) were derived from PET images. PET/CT parameters of the SCC patients were compared with those of the NHL patients. The diagnostic accuracy of the indices for differentiating SCC from NHL was calculated by a receiver operating characteristic curve analysis. 18F-FDG uptake in the oropharynx was observed in all of the patients. The SUVmax, MTV, and TLG did not differ significantly between the SCC and NHL groups, but two of the six texture indices (LGZE [p=0.004] and HGZE [p=0.03]) showed significant differences between the groups. LGZE was the best discriminative index for the differentiation of SCC and NHL (55.6% sensitivity, 88.0% specificity). The LGZE and HGZE texture indices derived from 18F-FDG PET/CT images may be useful in differentiating SCC and NHL in the oropharynx. |
| Keywords | 18F-FDG PET/CT oropharyngeal squamous cell carcinoma malignant lymphoma texture |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 351 |
| End Page | 356 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176939 |
| Web of Science KeyUT | 000667147700010 |
| NAID | 120007089827 |
