検索結果 524 件
| JaLCDOI | 10.18926/AMO/63887 |
|---|---|
| フルテキストURL | 76_4_359.pdf |
| 著者 | Hiramatsu-Asano, Sumie| Wada, Jun| |
| 抄録 | Systemic lupus erythematosus (SLE) is a potentially fatal systemic autoimmune disease, and its etiology involves both genetic and environmental factors such as sex hormone imbalance, genetic predisposition, epigenetic regulation, and immunological factors. Dysregulation of microRNA (miRNA) is suggested to be one of the epigenetic factors in SLE. miRNA is a 22-nucleotide single-stranded noncoding RNA that contributes to post-transcriptional modulation of gene expression. miRNA targeting therapy has been suggested to be useful for the treatment of cancers and other diseases. Gene knockout and miRNA targeting therapy have been demonstrated to improve SLE disease activity in mice. However, these approaches have not yet reached the level of clinical application. miRNA targeting therapy is limited by the fact that each miRNA has multiple targets. In addition, the expression of certain miRNAs may differ among cell tissues within a single SLE patient. This limitation can be overcome by targeted delivery and chemical modifications. In the future, further research into miRNA chemical modifications and delivery systems will help us develop novel therapeutic agents for SLE. |
| キーワード | systemic lupus erythematosus miRNA miRNA targeting therapy |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 359 |
| 終了ページ | 371 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123150 |
| Web of Science KeyUT | 000882167300002 |
| フルテキストURL | s41598-022-16279-z.pdf |
|---|---|
| 著者 | Takeuchi-Hatanaka, Kazu| Koyama, Yoshinobu| Okamoto, Kentaro| Sakaida, Kyosuke| Yamamoto, Tadashi| Takashiba, Shogo| |
| 発行日 | 2022-07-19 |
| 出版物タイトル | Scientific Reports |
| 巻 | 12巻 |
| 号 | 1号 |
| 出版者 | Nature Portfolio |
| 開始ページ | 12353 |
| ISSN | 2045-2322 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2022 |
| 論文のバージョン | publisher |
| PubMed ID | 35854051 |
| DOI | 10.1038/s41598-022-16279-z |
| Web of Science KeyUT | 000827810800083 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41598-022-16279-z |
| JaLCDOI | 10.18926/AMO/63747 |
|---|---|
| フルテキストURL | 76_3_349.pdf |
| 著者 | Ariyasu, Kanazu| Kimura, Shuhei| Matoba, Ryo| Morizane Hosokawa, Mio| Shiode, Yusuke| Doi, Shinichiro| Kanzaki, Yuki| Morizane, Yuki| |
| 抄録 | An 18-year-old male high school student presented to our clinic with bilateral blunt ocular trauma caused by an exercise resistance band (ERB) during a muscle-building exercise. Best-corrected decimal visual acuities (BCVAs) for right and left eyes were light perception and 0.15, respectively. The right eye was operated 10 days after injury for persistent vitreous hemorrhage, and the left eye 5 months later because of macular hole onset. After 36 months, the right eye showed extensive retinal degeneration (BCVA 0.04), and the left eye macular hole closure (BCVA 1.2). ERBs should be used cautiously as they can cause serious ocular trauma. |
| キーワード | exercise resistance band traumatic macular hole traumatic retinal degeneration bilateral blunt ocular trauma |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-06 |
| 巻 | 76巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 349 |
| 終了ページ | 354 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35790368 |
| Web of Science KeyUT | 000823568300016 |
| JaLCDOI | 10.18926/AMO/63744 |
|---|---|
| フルテキストURL | 76_3_333.pdf |
| 著者 | Akagawa, Manabu| Miyakoshi, Naohisa| Tsuchie, Hiroyuki| Kasukawa, Yuji| Kawaragi, Takashi| Nagahata, Itsuki| Suzuki, Masazumi| Yoshikawa, Takayuki| Abe, Toshiki| Shimada, Yoichi| |
| 抄録 | We report a case of atypical femoral fracture achieving early fracture union with combination therapy comprising contralateral nail and immediate teriparatide injection. Fracture union of atypical fractures is often delayed due to bowing deformity and bone metabolic disorders. Combination treatment that takes both problems into consideration represents a useful treatment option for atypical femoral fracture. |
| キーワード | atypical femoral fracture bowing deformity intramedullary nail teriparatide cephalomedullary screw |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-06 |
| 巻 | 76巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 333 |
| 終了ページ | 338 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35790365 |
| Web of Science KeyUT | 000823568300013 |
| JaLCDOI | 10.18926/AMO/63742 |
|---|---|
| フルテキストURL | 76_3_323.pdf |
| 著者 | Hosomoto, Kakeru| Sasaki, Tatsuya| Kawai, Koji| Okazaki, Yosuke| Hyodo, Yuki| Shibata, Takashi| Sasada, Susumu| Yasuhara, Takao| Kobayashi, Katsuhiro| Yanai, Hiroyuki| Date, Isao| |
| 抄録 | Cortical tubers are one of the typical intracranial manifestations of tuberous sclerosis complex (TSC). Multiple cortical tubers are easy to diagnose as TSC; however, a solitary cortical tuber without any other cutaneous or visceral organ manifestations can be confused with other conditions, particularly focal cortical dysplasia. We report a surgical case of refractory epilepsy caused by a solitary cortical tuber mimicking focal cortical dysplasia type II, and describe the radiological, electrophysiological, and histopathological findings of our case. |
| キーワード | cortical tuber epilepsy focal cortical dysplasia transmantle sign tuberous sclerosis complex |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-06 |
| 巻 | 76巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 323 |
| 終了ページ | 328 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35790363 |
| Web of Science KeyUT | 000823568300011 |
| JaLCDOI | 10.18926/AMO/63741 |
|---|---|
| フルテキストURL | 76_3_317.pdf |
| 著者 | Yamamoto, Norio| Inoue, Tomoo| Yusuke, Mochizuki| Tomoyuki, Noda| Keisuke, Kawasaki| Toshifumi, Ozaki| |
| 抄録 | Secondary hip fractures (SHFs) rarely occur after intramedullary nailing (IMN) fixation without femoral neck fixation for atypical femoral fractures (AFFs). We report three cases of older Japanese women who sustained SHFs presumably caused by osteoporosis and peri-implant stress concentration around the femoral neck after undergoing IMN without femoral neck fixation for AFF. All cases were fixed with malalignment. In AFF patients, postoperative changes due to postoperative femoral bone malalignment may affect the peri-implant mechanical environment around the femoral neck, which can result in insufficiency fractures. At the first AFF surgery, we recommend femoral neck fixation after adequate reduction is achieved. |
| キーワード | atypical femoral fracture bone malalignment intramedullary nail femoral neck fracture hip fracture |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-06 |
| 巻 | 76巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 317 |
| 終了ページ | 321 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35790362 |
| Web of Science KeyUT | 000823568300010 |
| JaLCDOI | 10.18926/AMO/63740 |
|---|---|
| フルテキストURL | 76_3_307.pdf |
| 著者 | Sugiura, Satoshi| Kitamura, Yoshihisa| Izushi, Yasuhisa| Ushio, Soichiro| Sendo, Toshiaki| |
| 抄録 | In recent years, medical staff including physicians and nurses have been participating in home health care, reflecting the needs of an aging society in Japan. Pharmacists are also asked to work on home health care teams to ensure the medical safety of patients. It currently remains unclear whether direct communication, i.e. a meeting, between home-visiting physicians and pharmacists contributes to the proper use of medications and continuous medical care. We retrospectively analyzed the medication management guidance records of home-visited patients who received their first home visit between April 2014 and March 2017. We collected data on pharmacist inquiries, the duration of visits, and details from a meeting between home-visiting physicians and pharmacists. Thirty-five patients were included. At the first visit, the inquiry rate by pharmacists was 65.7%. The prescription question rate was significantly lower in patients with a meeting than in those without (p=0.033). The average duration of visits was significantly shorter for home-visited patients whose health care providers had a meeting (p=0.007). These results suggest that pharmacists who held a meeting with the home-visiting physician before the first patient visit were able to resolve drug-related issues earlier, which increased the work efficiency of home-visiting pharmacists. |
| キーワード | home visit pharmacist meeting inquiry home health care |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-06 |
| 巻 | 76巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 307 |
| 終了ページ | 315 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35790361 |
| Web of Science KeyUT | 000823568300001 |
| JaLCDOI | 10.18926/AMO/63428 |
|---|---|
| フルテキストURL | 76_2_229.pdf |
| 著者 | Kono, Takashi| Monden, Nobuya| Chikuie, Nobuyuki| Taruya, Takayuki| Hamamoto, Takao| Ishino, Takashi| Ueda, Tsutomu| Takeno, Sachio| |
| 抄録 | We report a case of mandibular osteosarcoma in a Japanese woman in her 70s who was p16-positive. Despite the rapid growth of the tumor, the patient responded well to chemotherapy and was then able to undergo surgery. Head and neck osteosarcoma (HNOS) is a very rare cancer, and although the importance of surgery has been pointed out, the effectiveness of chemotherapy is unclear. Resection margin negativity and response to chemotherapy have been reported as prognostic factors; another report assessed the effectiveness of the immunohistochemical expression of p16 protein as a predictor of response to chemotherapy. |
| キーワード | head and neck osteosarcomas tumor suppressor p16 |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 229 |
| 終了ページ | 233 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503452 |
| Web of Science KeyUT | 000792291900006 |
| JaLCDOI | 10.18926/AMO/63427 |
|---|---|
| フルテキストURL | 76_2_225.pdf |
| 著者 | Mori, Yu| Sano, Yoshifumi| Sugimoto, Ryujiro| Sakao, Nobuhiko| Ryuko, Tsuyoshi| Takeda, Masashi| Kitazawa, Riko| Yukumi, Shungo| Izutani, Hironori| |
| 抄録 | A 75-year-old man presented to our hospital 1 year after partial renal resection for clear cell carcinoma. A right lower lobe lung nodule noted at the time of surgery had increased to 3.0 cm in diameter and was confirmed as squamous cell lung carcinoma by bronchoscopic cytology. Computed tomography had also revealed paratracheal lymph node swelling. He underwent right lower lobectomy with lymph node dissection by video-assisted thoracic surgery. Pathological examination confirmed squamous cell carcinoma of the lung but diagnosed the right hilar and mediastinal lymph node metastases as clear cell carcinoma. |
| キーワード | renal cell carcinoma primary lung cancer double cancer mediastinal lymph node metastasis hilar lymph node metastasis |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 225 |
| 終了ページ | 228 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503451 |
| Web of Science KeyUT | 000792291900005 |
| JaLCDOI | 10.18926/AMO/63426 |
|---|---|
| フルテキストURL | 76_2_217.pdf |
| 著者 | Yabuno, Satoru| Sasada, Susumu| Umakoshi, Michiari| Nagase, Takayuki| Sugahara, Chiaki| Kawauchi, Satoshi| Yasuhara, Takao| Date, Isao| |
| 抄録 | A 3-year-old boy had difficulty sitting up and walking for several months. Magnetic resonance imaging (MRI) revealed an intradural tumor at the L3-4 level. The tumor was successfully resected by unilateral hemilaminectomy and diagnosed as dermoid cyst. The patient had an uneventful postoperative course without pain, and MRI found no recurrence after surgery. A small bone defect remained that might be favorably reconstructed with autologous and artificial bone. Hemilaminectomy allowed us to resect the cauda equina dermoid cyst with minimal invasiveness. Pediatric patients require follow-up as they are more likely to experience spinal deformity or instability after surgery. |
| キーワード | cauda equina tumor child dermoid cyst hemilaminectomy spinal tumor |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 217 |
| 終了ページ | 223 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503450 |
| Web of Science KeyUT | 000792291900004 |
| JaLCDOI | 10.18926/AMO/63425 |
|---|---|
| フルテキストURL | 76_2_203.pdf |
| 著者 | Masuda, Tomoya| Tazawa, Hiroshi| Hashimoto, Yuuri| Ieda, Takeshi| Kikuchi, Satoru| Kuroda, Shinji| Noma, Kazuhiro| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| 抄録 | The epithelial-mesenchymal transition (EMT), a normal biological process by which epithelial cells acquire a mesenchymal phenotype, is associated with migration, metastasis, and chemoresistance in cancer cells, and with poor prognosis in patients with esophageal cancer. However, therapeutic strategies to inhibit EMT in tumor environments remain elusive. Here, we show the therapeutic potential of telomerase-specific replication- competent oncolytic adenovirus OBP-301 in human esophageal cancer TE4 and TE6 cells with an EMT phenotype. Transforming growth factor-β (TGF-β) administration induced the EMT phenotype with spindleshaped morphology, upregulation of mesenchymal markers and EMT transcription factors, migration, and chemoresistance in TE4 and TE6 cells. OBP-301 significantly inhibited the EMT phenotype via E1 accumulation. EMT cancer cells were susceptible to OBP-301 via massive autophagy induction. OBP-301 suppressed tumor growth and lymph node metastasis of TE4 cells co-inoculated with TGF-β-secreting fibroblasts. Our results suggest that OBP-301 inhibits the TGF-β-induced EMT phenotype in human esophageal cancer cells. OBP-301-mediated E1A overexpression is a promising antitumor strategy to inhibit EMT-mediated esophageal cancer progression. |
| キーワード | esophageal cancer EMT TGF-β oncolytic adenovirus E1A |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 203 |
| 終了ページ | 215 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503449 |
| Web of Science KeyUT | 000792291900003 |
| JaLCDOI | 10.18926/AMO/63410 |
|---|---|
| フルテキストURL | 76_2_167.pdf |
| 著者 | Higashionna, Tsukasa| Ushio, Soichiro| Esumi, Satoru| Murakawa, Kiminaka| Kitamura, Yoshihisa| Sendo, Toshiaki| |
| 抄録 | Febrile neutropenia (FN) is a serious side effect in patients undergoing cancer chemotherapy and frequently proves fatal. Since infection control is crucial in the management of FN, the antimicrobial agent cefozopran (CZOP) has been recommended but not approved for routine use in clinical care of FN in Japan. However, few studies of CZOP in the management of FN have used a thrice daily dose schedule. The aim of this study was to retrospectively compare the efficacy and safety of CZOP at a dose of 1 g three times daily to those of cefepime (CFPM) in the treatment of FN in our lung cancer patients. The response rates of the CZOP and CFPM groups were 89.5% (17/19 cases) and 83.0% (39/47 cases), respectively, with no significant difference between the two groups. The median duration of antimicrobial treatment was 6 days (4-10 days) in the CZOP group and 7 days (3-13 days) in the CFPM group, with no significant difference between groups. The incidence rates of adverse events were 21.1% (4/19 cases) in the CZOP group and 19.1% (9/47 cases) in the CFPM group. No adverse events of Grade 3 or higher were observed in either group. The findings of the present study suggest that CZOP administration at a dose of 1 g three times per day as an antimicrobial treatment alternative against FN. |
| キーワード | febrile neutropenia cefozopran cefepime lung cancer retrospective |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 167 |
| 終了ページ | 172 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503444 |
| Web of Science KeyUT | 000792374900008 |
| JaLCDOI | 10.18926/AMO/63409 |
|---|---|
| フルテキストURL | 76_2_155.pdf |
| 著者 | Kimura, Jiro| Okabayashi, Takehiro| Sui, Kenta| Tabuchi, Motoyasu| Iwata, Jun| Hata, Yasuhiro| Iiyama, Tatsuo| Ono, Noriaki| |
| 抄録 | Small bowel metastasis from renal cell carcinoma (RCC) is rare, and its clinicopathological characteristics are unclear; thus, we revisited the concept of this tumor and reviewed its diagnostic and treatment modalities. We filtered MEDLINE searches of articles published in English between 1950 and 2019, and identified 100 patients who had undergone treatment, including 1 patient from our clinic. We extracted patient characteristics, treatment, and prognostic data, resulting in clinicopathological data on 100 patients (83 men, 17 women). Mean age was 63 years (range, 16-86 years). Tumor sites were duodenum, jejunum, ileum, and multiple sites in 30, 37, 25, and 7 patients, respectively. The 1-, 3-, and 5-year overall survival rates after diagnosis were 53.0%, 36.0%, and 36.0%. Curative resection patients showed 62.1% 5-year survival after surgery, vs. 27.5% in noncurative surgical management cases. Good prognoses can be expected if these tumors are identified early for complete removal. Surgery is the only curative option. To determine the best management strategy and improve prognostic accuracy, we continue to collect and analyze epidemiological and pathological data. Although this condition is rare, surgery should be considered if curative resection is expected. Prognosis after curative resection is not poor, but recurrence is not unlikely. |
| キーワード | renal cell carcinoma small bowel metastasis intestine tumor |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-04 |
| 巻 | 76巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 155 |
| 終了ページ | 165 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35503443 |
| Web of Science KeyUT | 000792374900007 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Tabuchi, Masako| Inoue, Katsumi| Usui-Kataoka, Hitomi| Kobayashi, Kazuko| Teramoto, Misako| Takasugi, Koji| Shikata, Kenichi| Yamamura, Masahiro| Ando, Kenji| Nishida, Keiichiro| Kasahara, Junko| Kume, Noriaki| Lopez, Luis R.| Mitsudo, Kazuaki| Nobuyoshi, Masakiyo| Yasuda, Tatsuji| Kita, Toru| Makino, Hirofumi| Matsuura, Eiji| |
| キーワード | beta 2-glycoprotein I oxidized LDL/beta 2-glycoprotein I complexes diabetes mellitus oxidized LDL |
| 発行日 | 2007-04 |
| 出版物タイトル | Journal Of Lipid Research |
| 巻 | 48巻 |
| 号 | 4号 |
| 出版者 | ELSEVIER |
| 開始ページ | 768 |
| 終了ページ | 781 |
| ISSN | 0022-2275 |
| NCID | AA00701215 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2007 by the American Society for Biochemistry and Molecular Biology, Inc. |
| 論文のバージョン | publisher |
| PubMed ID | 17261875 |
| DOI | 10.1194/jlr.M600414-JLR200 |
| Web of Science KeyUT | 000245627100003 |
| 関連URL | isVersionOf https://doi.org/10.1194/jlr.M600414-JLR200 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Mizuno, Tomofumi| Nishii, Nobuhiro| Morita, Hiroshi| Ito, Hiroshi| |
| キーワード | Transvenous pacemaker Fontan operation Sinus node dysfunction Atrial tachycardia Case report |
| 発行日 | 2022-01-13 |
| 出版物タイトル | European Heart Journal-Case Reports |
| 巻 | 6巻 |
| 号 | 1号 |
| 出版者 | Oxford Univ Press |
| 開始ページ | ytac003 |
| ISSN | 2514-2119 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2022. |
| 論文のバージョン | publisher |
| PubMed ID | 35059560 |
| DOI | 10.1093/ehjcr/ytac003 |
| Web of Science KeyUT | 000753349900033 |
| 関連URL | isVersionOf https://doi.org/10.1093/ehjcr/ytac003 |
| JaLCDOI | 10.18926/AMO/63219 |
|---|---|
| フルテキストURL | 76_1_99.pdf |
| 著者 | Naito, Yoichiro| Yoshikawa, Masaki| Nakamura, Kazufumi| Kubo, Motoki| Sugiyama, Hiroyasu| Suzuki, Hideyuki| Fujita, Shinpei| Arai, Yasunori| Takahashi, Sho| Kato, Yuichi| Yoshida, Yu| Akai, Hiroaki| Murakami, Shuhei| Ito, Hiroshi| |
| 抄録 | Rapidly progressive in-stent restenosis (ISR) after stent deployment from the left main trunk (LMT) to the left anterior descending artery (LAD) without plaque at the LMT ostium has not been reported. A 60-year-old Japanese man with a history of scleroderma, pulmonary fibrosis, and type 2 diabetes developed acute myocardial infarction of the right coronary artery (RCA) and was treated by emergency percutaneous coronary intervention (PCI) for RCA. Nine days later he underwent PCI from the LMT to the LAD. Follow-up coronary angiography (CAG) at 9 and 21 months post-PCI did not reveal ISR in any lesion, but the patient experienced cardiac arrest at 25 months post-PCI. Emergency CAG after resuscitation revealed ISR of the LMT ostium; emergency PCI was conducted. The development of ISR at the ostium of the LMT although the patient was free of plaque 4 months before is extremely unusual. This rare ISR of the LMT ostium progressed rapidly after follow-up CAG revealed no ISR at 21 months post-stent implantation. |
| キーワード | left main trunk in-stent restenosis cardiopulmonary arrest |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-02 |
| 巻 | 76巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 99 |
| 終了ページ | 104 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35237006 |
| Web of Science KeyUT | 000762933000003 |
| JaLCDOI | 10.18926/AMO/63218 |
|---|---|
| フルテキストURL | 76_1_93.pdf |
| 著者 | Ishi, Yukitomo| Yamaguchi, Shigeru| Hatanaka, Kanako C.| Takakuwa, Emi| Motegi, Hiroaki| Honda, Taishi| Kobayashi, Hiroyuki| Terasaka, Shunsuke| Homma, Akihiro| Fujimura, Miki| Houkin, Kiyohiro| |
| 抄録 | A 66-year-old man underwent multimodal treatment for olfactory neuroblastoma (ONB). When he was 72 years old, a cystic intracranial lesion without accumulation on fluorine-18-fluorodeoxyglucose positron emission tomography was detected. Surgical resection was performed when the patient was 73 years old. The pathological examination revealed recurrence of ONB, and the patient underwent focal irradiation. At age 81, he presented with a second recurrence in the right occipital lobe with radiological and pathological findings similar to the prior recurrence. This case suggests that pathological confirmation should be considered in cases with atypical radiological findings following the treatment of ONB. |
| キーワード | cystic recurrence esthesioneuroblastoma fluorine-18-fluorodeoxyglucose positron emission tomography intracranial recurrence olfactory neuroblastoma |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-02 |
| 巻 | 76巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 93 |
| 終了ページ | 98 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35237005 |
| Web of Science KeyUT | 000762933000002 |
| JaLCDOI | 10.18926/AMO/63217 |
|---|---|
| フルテキストURL | 76_1_89.pdf |
| 著者 | Ryuko, Tsuyoshi| Yamamoto, Hiromasa| Sugimoto, Seiichiro| Suzawa, Ken| Miyoshi, Kentaroh| Otani, Shinji| Okazaki, Mikio| Yamane, Masaomi| Toyooka, Shinichi| |
| 抄録 | Congenital lobar emphysema (CLE) is defined as the hyperinflation of pulmonary lobes due to obstruction of the flow of air via a known or unknown etiology, which causes pressure symptoms in the adjacent organs. CLE is mainly diagnosed in the neonatal period, and very few adult cases have been reported. Here we report a 34-year-old male with muscular dystrophy who was diagnosed with CLE on examination. He underwent a right lower lobectomy via 3-portal completely video-assisted thoracoscopic surgery, and his symptoms improved. Thoracoscopic surgery helped preserve the respiratory muscles and led to the improvement of respiratory function in this patient. |
| キーワード | congenital lobar emphysema, adult, lobectomy, completely video-assisted thoracoscopic surgery, muscular dystrophy |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-02 |
| 巻 | 76巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 89 |
| 終了ページ | 92 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35237004 |
| Web of Science KeyUT | 000762933000001 |
| JaLCDOI | 10.18926/AMO/63213 |
|---|---|
| フルテキストURL | 76_1_63.pdf |
| 著者 | Zhang, Bei| Pei, Zhixin| Wang, Hongxia| Wu, Huimin| Wang, Junjie| Bai, Junjun| Song, Qinglin| |
| 抄録 | We analyzed the treatment effects of chidamide and decitabine in combination with a HAG (homoharringtonine, cytarabine, G-CSF) priming regimen (CDHAG) in acute myeloid leukemia (AML) patients with TP53 mutation. Seven TP53 mutated AML patients were treated with CDHAG. The treatment effects were assessed using hemogram detection and bone marrow aspirate. The possible side effects were evaluated based on both hematological and non-hematological toxicity. Four of the seven patients were classified as having achieved complete remission after CDHAG treatment; one patient was considered to have achieved partial remission, and the remaining two patients were considered in non-remission. The overall response rate (ORR) to CDHAG was 71.4%. Regarding the side effects, the hematological toxicity level of the seven patients ranged from level III to level IV, and infections that occurred at lung, blood, and skin were recorded. Nausea, vomiting, liver injury, and kidney injury were also detected. However, all side effects were attenuated by proper management. The CDHAG regimen clearly improved the ORR (71.4%) of TP53-mutated AML patients, with no severe side effects. |
| キーワード | acute myeloid leukemia chidamide decitabine HAG TP53 mutation |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-02 |
| 巻 | 76巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 63 |
| 終了ページ | 70 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35237000 |
| Web of Science KeyUT | 000762812700009 |
| JaLCDOI | 10.18926/AMO/63207 |
|---|---|
| フルテキストURL | 76_1_41.pdf |
| 著者 | Miyahara, Hiroyuki| Miyai, Takayuki| Aya, Kunihiko| Tsukahara, Hirokazu| |
| 抄録 | High-dose steroids are required for the treatment of minimal change nephrotic syndrome (MCNS), especially for episodes of recurrence. Predicting and avoiding recurrence can help reduce the steroid dose, but prediction is currently difficult. We herein examined whether changes in laboratory data, especially the urinary protein- to-creatinine ratio (UTP/UCr), can predict clinical recurrence. We also assessed differences in clinical features between children and young adults. We included 36 patients with MCNS; for each case, we retrospectively studied laboratory data during stable remission and pre-recurrence, with the “stable” period defined as all but the 6 weeks before recurrence, and pre-recurrence defined as the 4±2 weeks before recurrence. UTP/UCr, serum albumin, etc. were measured every 5 years during stable periods. We divided patients into cohorts by age at recurrence, < 15 years and ≥ 15 years, and compared stable and pre-recurrence values for the two groups. UTP/UCr values during stable periods tended to be higher in younger patients. UTP/UCr and serum albumin showed statistically significant changes during pre-recurrence periods, but only in those aged ≥ 15 years. Thus, clinical features of recurrence differed depending on age. Signs of recurrence can be confirmed via UTP/UCr or serum albumin several weeks before recurrence in patients ≥ 15 years. |
| キーワード | minimal change nephrotic syndrome recurrence urinary protein to creatinine ratio |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-02 |
| 巻 | 76巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 41 |
| 終了ページ | 49 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35236997 |
| Web of Science KeyUT | 000762812700006 |