検索結果 25004 件
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Hemmi, Ryota| Ujihara, Takehito| Ando, Ryosuke| Hashimoto, Seiji| |
| キーワード | image classification machine learning sprawl |
| 発行日 | 2026-02-06 |
| 出版物タイトル | Land |
| 巻 | 15巻 |
| 号 | 2号 |
| 出版者 | MDPI AG |
| 開始ページ | 275 |
| ISSN | 2073-445X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2026 by the authors. |
| 論文のバージョン | publisher |
| DOI | 10.3390/land15020275 |
| 関連URL | isVersionOf https://doi.org/10.3390/land15020275 |
| フルテキストURL | fulltext.pdf |
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| 著者 | Takeuchi, Noriko| Sawada, Nanami| Inada, Sakura| Morita, Manabu| Ekuni, Daisuke| |
| 発行日 | 2026-01-09 |
| 出版物タイトル | Communications Medicine |
| 巻 | 6巻 |
| 号 | 1号 |
| 出版者 | Springer Science and Business Media LLC |
| 開始ページ | 96 |
| ISSN | 2730-664X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2026 |
| 論文のバージョン | publisher |
| PubMed ID | 41513837 |
| DOI | 10.1038/s43856-025-01361-0 |
| Web of Science KeyUT | 001686043700001 |
| 関連URL | isVersionOf https://doi.org/10.1038/s43856-025-01361-0 |
| フルテキストURL | fulltext.pdf |
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| 著者 | Fujii, Yasushi| Nakayama, Takahiro| Oshita, Junki| Tsunoda, Ayaka| Saeki, Yusuke| Tanabe, Yoshinori| |
| キーワード | flex map sagging Winston–Lutz test |
| 発行日 | 2026 |
| 出版物タイトル | Journal of Radiotherapy in Practice |
| 巻 | 25巻 |
| 出版者 | Cambridge University Press (CUP) |
| 開始ページ | e5 |
| ISSN | 1460-3969 |
| NCID | AA11974173 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s), 2026. |
| 論文のバージョン | publisher |
| DOI | 10.1017/s1460396926100387 |
| 関連URL | isVersionOf https://doi.org/10.1017/s1460396926100387 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Hagiya, Hideharu| Nishimura, Yoshito| Harada, Ko| Yamamoto, Maki| Takeda, Tatsuaki| Vu, Quynh Thi| Belangoy, Keith Pardillada| Ouddoud, Hanane| Zamami, Yoshito| Koyama, Toshihiro| |
| キーワード | Aging Locally weighted regression model Infection Clostridioides difficile Disparity |
| 発行日 | 2026-03 |
| 出版物タイトル | International Journal of Infectious Diseases |
| 巻 | 164巻 |
| 出版者 | Elsevier BV |
| 開始ページ | 108315 |
| ISSN | 1201-9712 |
| NCID | AA11238338 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2025 The Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 41456768 |
| DOI | 10.1016/j.ijid.2025.108315 |
| Web of Science KeyUT | 001678827200001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.ijid.2025.108315 |
| 著者 | Fukushima, Shinnosuke| Sumida, Takaomi| Kawamata, Osamu| Hidani, Yoshimi| Hagiya, Hideharu| |
|---|---|
| キーワード | Epidemiology Japanese spotted fever Spotted fever group rickettsiae Tick bite Tick-borne disease |
| 備考 | © 2026 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Feb. 2027.| |
| 発行日 | 2026-03 |
| 出版物タイトル | Journal of Infection and Chemotherapy |
| 巻 | 32巻 |
| 号 | 3号 |
| 出版者 | Elsevier BV |
| 開始ページ | 102931 |
| ISSN | 1341-321X |
| NCID | AA11057978 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2026 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. |
| 論文のバージョン | author |
| PubMed ID | 41720337 |
| DOI | 10.1016/j.jiac.2026.102931 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.jiac.2026.102931 |
| 著者 | Ogawa, Sakura| Fukushima, Shinnosuke| Yamamoto, Mari| Tsuji, Shuma| Gotoh, Kazuyoshi| Hagiya, Hideharu| |
|---|---|
| 備考 | © 2026 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Feb. 2027.| |
| 発行日 | 2026-03 |
| 出版物タイトル | Journal of Infection and Chemotherapy |
| 巻 | 32巻 |
| 号 | 3号 |
| 出版者 | Elsevier BV |
| 開始ページ | 102933 |
| ISSN | 1341-321X |
| NCID | AA11057978 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2026 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. |
| 論文のバージョン | author |
| PubMed ID | 41707498 |
| DOI | 10.1016/j.jiac.2026.102933 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.jiac.2026.102933 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Takeuchi, Junko S| Matsunaga, Nobuaki| Tsukada, Ai| Iwamoto, Noriko| Fuwa, Noriko| Ichikawa, Takahiro| Kato, Yasuyuki| Tomita, Yuka| Kitagawa, Hiroki| Yamato, Masaya| Aoyagi, Tetsuji| Hagiya, Hideharu| Hase, Ryota| Hatakeyama, Shuji| Inaba, Tohru| Izumikawa, Koichi| Takesue, Yoshio| Kimura, Moto| Ohmagari, Norio| |
| キーワード | influenza a nasal vestibular swab nasopharyngeal swab rapid diagnostics rt-qpcr saliva sari |
| 発行日 | 2026-01-05 |
| 出版物タイトル | Cureus |
| 巻 | 18巻 |
| 号 | 1号 |
| 出版者 | Springer Science and Business Media LLC |
| 開始ページ | e100872 |
| ISSN | 2168-8184 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © Copyright 2026 Takeuchi et al. |
| 論文のバージョン | publisher |
| PubMed ID | 41658625 |
| DOI | 10.7759/cureus.100872 |
| 関連URL | isVersionOf https://doi.org/10.7759/cureus.100872 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Nishio, Ayano| Iwamuro, Masaya| Inokuchi, Toshihiro| Ishiguro, Mikako| Aoyama, Yuki| Takahara, Masahiro| Hiraoka, Sakiko| Oguni, Kohei| Hagiya, Hideharu| Matsuoka, Yuto| Kanazawa, Tomoyuki| Otsuka, Motoyuki| |
| キーワード | crohn’s disease (cd) group a streptococcus immunosuppression intestinal obstruction streptococcal toxic shock syndrome (stss) |
| 発行日 | 2025-12-26 |
| 出版物タイトル | Cureus |
| 巻 | 17巻 |
| 号 | 12号 |
| 出版者 | Springer Science and Business Media LLC |
| 開始ページ | e100138 |
| ISSN | 2168-8184 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © Copyright 2025 Nishio et al. |
| 論文のバージョン | publisher |
| PubMed ID | 41589146 |
| DOI | 10.7759/cureus.100138 |
| 関連URL | isVersionOf https://doi.org/10.7759/cureus.100138 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Hayashi, Tatsuya| Okazaki, Mikio| Mitsuhashi, Toshiharu| Yamamoto, Hidetaka| Habu, Tomohiro| Shien, Kazuhiko| Suzawa, Ken| Yamamoto, Hiromasa| Otsuka, Tomoaki| Watanabe, Mototsugu| Kurosaki, Takeshi| Yamada, Eiji| Matsuda, Eisuke| Hayashi, Tatsurou| Fujiwara, Toshiya| Hayama, Makio| Tao, Hiroyuki| Yamane, Masaomi| Inokawa, Hidetoshi| Hirami, Yuji| Washio, Kazuhiro| Misao, Takahiko| Yamashita, Motohiro| Sano, Yoshifumi| Nakata, Masao| Kawamata, Osamu| Toyooka, Shinichi| |
| キーワード | partial thymectomy real-world data analysis retrospective comparative cohort study thymic carcinoma thymic epithelial tumors total thymectomy |
| 発行日 | 2025-10-10 |
| 出版物タイトル | International Journal of Surgery |
| 巻 | 112巻 |
| 号 | 2号 |
| 出版者 | Ovid Technologies (Wolters Kluwer Health) |
| 開始ページ | 2301 |
| 終了ページ | 2310 |
| ISSN | 1743-9159 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2025 The Author(s). Published by Wolters Kluwer Health, Inc. |
| 論文のバージョン | publisher |
| PubMed ID | 41085661 |
| DOI | 10.1097/js9.0000000000003600 |
| 関連URL | isVersionOf https://doi.org/10.1097/js9.0000000000003600 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Imano, Natsumi| Nishida, Mikako| Tokumasu, Miho| Zhao, Weiyang| Yamashita, Nahoko| Udono, Heiichiro| |
| キーワード | ascochlorin derivative CD8 positive T lymphocytes cell survival IFN-γ interleukin-9 Tc9 tumour immunity |
| 発行日 | 2026-02-19 |
| 出版物タイトル | British Journal of Pharmacology |
| 出版者 | Wiley |
| ISSN | 0007-1188 |
| NCID | AA00574810 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2026 The Author(s). |
| 論文のバージョン | publisher |
| PubMed ID | 41715914 |
| DOI | 10.1111/bph.70316 |
| 関連URL | isVersionOf https://doi.org/10.1111/bph.70316 |
| フルテキストURL | fulltext.pdf |
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| 著者 | Matsuoka, Daiki| Suehara, Kana| Naka, Shuhei| Misaki, Taro| Nagasawa, Yasuyuki| Ito, Seigo| Suehiro, Yuto| Nomura, Ryota| Nakano, Kazuhiko| Matsumoto-Nakano, Michiyo| |
| キーワード | bacterial surface proteins collagen-binding protein human immunoglobulins IgA nephropathy Streptococcus mutans |
| 発行日 | 2026-01-07 |
| 出版物タイトル | Frontiers in Cellular and Infection Microbiology |
| 巻 | 15巻 |
| 出版者 | Frontiers Media SA |
| 開始ページ | 1673581 |
| ISSN | 2235-2988 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2026 Matsuoka, Suehara, Naka, Misaki, Nagasawa, Ito, Suehiro, Nomura, Nakano and Matsumoto-Nakano. |
| 論文のバージョン | publisher |
| PubMed ID | 41574301 |
| DOI | 10.3389/fcimb.2025.1673581 |
| Web of Science KeyUT | 001665990400001 |
| 関連URL | isVersionOf https://doi.org/10.3389/fcimb.2025.1673581 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Kong, Dezheng| Funabiki, Nobuo| Kyaw, Htoo Htoo Sandi| Kotama, I Nyoman Darma| Zhu, Zihao| Rahmadani, Alfiandi Aulia| |
| キーワード | internet of things AI retrieval-augmented generation vector database schema-based extraction data sheet technical information |
| 発行日 | 2026-02-07 |
| 出版物タイトル | Sensors |
| 巻 | 26巻 |
| 号 | 4号 |
| 出版者 | MDPI AG |
| 開始ページ | 1081 |
| ISSN | 1424-8220 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2026 by the authors. |
| 論文のバージョン | publisher |
| DOI | 10.3390/s26041081 |
| 関連URL | isVersionOf https://doi.org/10.3390/s26041081 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Haz, Amma Liesvarastranta| Brata, Komang Candra| Funabiki, Nobuo| Kyaw, Htoo Htoo Sandi| Fajrianti, Evianita Dewi| Sukaridhoto, Sritrusta| |
| キーワード | slide annotation multimodal analysis speech-to-text LLM SUS |
| 発行日 | 2026-02-01 |
| 出版物タイトル | Algorithms |
| 巻 | 19巻 |
| 号 | 2号 |
| 出版者 | MDPI AG |
| 開始ページ | 110 |
| ISSN | 1999-4893 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2026 by the authors. |
| 論文のバージョン | publisher |
| DOI | 10.3390/a19020110 |
| 関連URL | isVersionOf https://doi.org/10.3390/a19020110 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Wardani, Ni Wayan| Funabiki, Nobuo| Kyaw, Htoo Htoo Sandi| Zhu, Zihao| Kotama, I Nyoman Darma| Sugiartawan, Putu| Putra, I Nyoman Agus Suarya| |
| キーワード | database programming SQL query description problem (SDP) self-study programming learning assistant system (PLAS) generative AI |
| 発行日 | 2026-01-09 |
| 出版物タイトル | Information |
| 巻 | 17巻 |
| 号 | 1号 |
| 出版者 | MDPI AG |
| 開始ページ | 65 |
| ISSN | 2078-2489 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2026 by the authors. |
| 論文のバージョン | publisher |
| DOI | 10.3390/info17010065 |
| Web of Science KeyUT | 001670537100001 |
| 関連URL | isVersionOf https://doi.org/10.3390/info17010065 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Permatasari, Perwira Annissa Dyah| Mentari, Mustika| Kinari, Safira Adine| Aung, Soe Thandar| Funabiki, Nobuo| Kyaw, Htoo Htoo Sandi| Wai, Khaing Hsu| |
| キーワード | Java programming learning JPLAS JUnit code writing problem plagiarism Levenshtein distance threshold IQR AI-generated |
| 発行日 | 2025-12-26 |
| 出版物タイトル | Analytics |
| 巻 | 5巻 |
| 号 | 1号 |
| 出版者 | MDPI AG |
| 開始ページ | 2 |
| ISSN | 2813-2203 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2025 by the authors. |
| 論文のバージョン | publisher |
| DOI | 10.3390/analytics5010002 |
| 関連URL | isVersionOf https://doi.org/10.3390/analytics5010002 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Zhu, Zihao| Funabiki, Nobuo| Sandi Kyaw, Htoo Htoo| Kotama, I Nyoman Darma| Pradhana, Anak Agung Surya| Rahmadani, Alfiandi Aulia| Noprianto| |
| キーワード | IoT MQTT protocol AI-assisted learning exercise-based education Python programming docker learning platform |
| 発行日 | 2025-12-18 |
| 出版物タイトル | Electronics |
| 巻 | 14巻 |
| 号 | 24号 |
| 出版者 | MDPI AG |
| 開始ページ | 4967 |
| ISSN | 2079-9292 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2025 by the authors. |
| 論文のバージョン | publisher |
| DOI | 10.3390/electronics14244967 |
| Web of Science KeyUT | 001646413000001 |
| 関連URL | isVersionOf https://doi.org/10.3390/electronics14244967 |
| JaLCDOI | 10.18926/AMO/70075 |
|---|---|
| フルテキストURL | 80_1_069.pdf |
| 著者 | Wakatsuki, Shinya| Sakamoto, Shinya| Ueno, Akiko| Namba, Takaomi| Yamamoto, Yorito| Matsumoto, Manabu| Iwata, Jun| Okabayashi, Takehiro| |
| 抄録 | Patients with hepatocellular carcinoma (HCC) and extensive peritoneal dissemination generally have a poor prognosis and are often resistant to systemic therapy. We report the case of a 47-year-old woman with HCC and massive peritoneal dissemination who presented with malignant ascites requiring repeated cell-free and concentrated ascites reinfusion therapy and peritoneovenous shunt placement, as well as malignant pleural effusion requiring pleurodesis. Combined immunotherapy with durvalumab/tremelimumab was initiated;however, disease progression was observed after three treatment courses, prompting a switch to lenvatinib therapy. Two months after initiation of lenvatinib, CT imaging demonstrated complete disappearance of arterial enhancement in the primary hepatic lesion, along with reduction in the size of peritoneal dissemination nodules. Thirteen months after switching to lenvatinib (16 months after the initial diagnosis), the alpha-fetoprotein level continued to decrease, and the disease remained stable under treatment. Despite the extremely high tumor burden, lenvatinib achieved disease stabilization and symptomatic improvement. |
| キーワード | diagnostic laparoscopy hepatocellular carcinoma peritoneal dissemination lenvatinib |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-02 |
| 巻 | 80巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 69 |
| 終了ページ | 74 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 41748152 |
| Web of Science KeyUT | 001712986800001 |
| JaLCDOI | 10.18926/AMO/70074 |
|---|---|
| フルテキストURL | 80_1_063.pdf |
| 著者 | Takasu, Eri| Shiode, Yusuke| Kindo, Hiroya| Kimura, Shuhei| Hosokawa, Mio| Matoba, Ryo| Kanzaki, Yuki| Morita, Tetsuro| Adachi, Takuya| Otsuka, Motoyuki| Morizane, Yuki| |
| 抄録 | A 77-year-old man undergoing treatment for hepatocellular carcinoma (HCC) presented with blurred vision in his right eye, persisting for 2 months. Slit-lamp microscopy and fundus examination revealed inflammatory cells in the anterior chamber, severe vitreous opacities, and retinal vasculitis in the right eye. The patient underwent vitreous surgery with biopsy, and vitreous cytology confirmed a metastatic intraocular tumor originating from the HCC. Radiotherapy was administered to the right eye, with no recurrence of intraocular inflammation observed at 10 months post-irradiation. |
| キーワード | metastatic intraocular tumor hepatocellular carcinoma panuveitis uveitis masquerade syndrome |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-02 |
| 巻 | 80巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 63 |
| 終了ページ | 67 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 41748151 |
| Web of Science KeyUT | 001712997700001 |
| JaLCDOI | 10.18926/AMO/70073 |
|---|---|
| フルテキストURL | 80_1_055.pdf |
| 著者 | Akazawa, Hidemasa| Hagiya, Hideharu| Fukushima, Shinnosuke| Yamamoto, Shohei| Nakano, Yasuhiro| Otsuka, Fumio| |
| 抄録 | In Japan, antiviral agents for COVID-19 were freely available until September 2023 as part of national policy. This study evaluated changes in these agents’ prescribing patterns and the patient outcomes following the policy shift. We conducted a multicenter retrospective study at four hospitals in Japan’s Okayama and Kagawa prefectures from January 2022 to March 2024. The study period was divided into the public-expenditure phase (January 2022 to September 2023) and the post-expenditure phase (October 2023 to March 2024). We extracted the hospitalized patients’ clinical data from the electronic database. The study’s primary outcome was the antiviral prescription rate; the secondary outcome was in-hospital mortality. Among the 302 hospitalized patients (median age 85 years), 52.0% were classified as having a mild condition. Of the patients with mild conditions, 37.7% were diagnosed in outpatient settings prior to hospitalization. During the public-expenditure phase, 47.4% of the patients received antivirals as outpatients, mainly molnupiravir (80.9%). In the post-expenditure period, 80.0% of the patients were prescribed antivirals, mostly molnupiravir (91.7%). The antiviral prescription rate was significantly higher after the policy change. The overall in-hospital mortality was 15.8%, with no significant difference between the two periods (17.0% vs. 10.5%). Despite the termination of government funding, antiviral prescriptions remained frequent at community hospitals located in highly aging regions of western Japan such as Okayama and Kagawa prefectures. Mortality remains high among the elderly, highlighting the need for continued antiviral therapy and booster vaccinations. |
| キーワード | coronavirus disease 2019 public expenditure prescribing pattern prognosis Japan |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-02 |
| 巻 | 80巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 55 |
| 終了ページ | 62 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 41748150 |
| Web of Science KeyUT | 001712994500007 |
| JaLCDOI | 10.18926/AMO/70072 |
|---|---|
| フルテキストURL | 80_1_047.pdf |
| 著者 | Eguchi, Yukiomi| Ushio, Soichiro| Irie, Keiichi| Yamashita, Yuta| Eguchi, Miyu| Nakano, Takafumi| Mishima, Kenichi| |
| 抄録 | Deregulation of cannabis use is gradually expanding in Europe and the United States. However, the biological processes driving tolerance to delta-9-tetrahydrocannabinol (Δ9-THC), the main psychoactive component of cannabis, remain unclear. Thus, this study aimed to investigate the mechanisms and time course of tolerance development and loss to Δ9-THC in mice. Male ICR mice (7 weeks old) were administered Δ9-THC once daily for 3 days and then divided into three groups according to the washout period (3-, 10-, and 17-day washout groups). After each washout, changes in body temperature and locomotor activity were measured following re-exposure to Δ9-THC. Furthermore, the mRNA expression levels of CB1 and CB2 receptors in the brain were evaluated using real-time PCR. On day 1, significant hypothermia and reduced spontaneous locomotor activity were observed in the Δ9-THC-treated mice compared with the vehicle-treated mice. Tolerance to the hypothermic and locomotor-suppressing effects of Δ9-THC developed on days 2 and 3, respectively, and dissipated after 3 and 11 days of washout, respectively. These differences in the rates of tolerance development and recovery may reflect distinct underlying mechanisms. No significant changes in receptor mRNA expression were observed. These findings highlight the complexity of Δ9-THC tolerance and its potential implications for long-term cannabis use. |
| キーワード | delta-9-tetrahydrocannabinol cannabis tolerance locomotor hypothermic |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2026-02 |
| 巻 | 80巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 47 |
| 終了ページ | 54 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2026 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 41748149 |
| Web of Science KeyUT | 001712994500006 |