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JaLCDOI 10.18926/AMO/63896
フルテキストURL 76_4_415.pdf
著者 Kang, Haijun| Huang, Dongmei| Kang, Gangjin| Yang, Xu| Li, Heng| Liu, Siyuan| Gou, Wenjun| Liu, Linglin| Qiu, Yuyan|
抄録 Posterior capsule opacification (PCO) is a post-surgery complication of cataract surgery, and lens epithelial cells (LECs) are involved in its development. A suppressive effect on LECs is exerted by the non specific chloride channel inhibitor 5-nitro-2-(3-phenylpropylamino) benzoic acid (NPPB) exerts. Herein, the growth and migration inhibitory effects of NPPB on LECs were assessed, and the mechanism underlying the effects were investigated by focusing on Ca2+/CaMKII signaling. LECs were treated with different concentrations of NPPB, and the changes in cell viability, cell-cycle distribution, anchorage-dependent growth, migration, Ca2+ level, and CaMKII expression were evaluated. NPPB inhibited LECs’ proliferation and induced G1 cell-cycle arrest in the cells. Regarding LECs’ mobility, NPPB suppressed the cells’ anchorage-dependent growth ability and inhibited their migration. Changes in cell phenotypes were associated with an increased intracellular Ca2+ level and down-regulation of CaMKII. Together these results confirmed the inhibitory effect of NPPB on the proliferation and migration of LECs, and the effect was shown to be associated with the induced level of Ca2+ and the inhibition of CaMKII signaling transduction.
キーワード 5-nitro-2-(3-phenylpropylamino) benzoic acid CaMKII lens epithelial cell migration proliferation
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-08
76巻
4号
出版者 Okayama University Medical School
開始ページ 415
終了ページ 421
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 36123156
Web of Science KeyUT 000882167300007
JaLCDOI 10.18926/AMO/63887
フルテキストURL 76_4_359.pdf
著者 Hiramatsu-Asano, Sumie| Wada, Jun|
抄録 Systemic lupus erythematosus (SLE) is a potentially fatal systemic autoimmune disease, and its etiology involves both genetic and environmental factors such as sex hormone imbalance, genetic predisposition, epigenetic regulation, and immunological factors. Dysregulation of microRNA (miRNA) is suggested to be one of the epigenetic factors in SLE. miRNA is a 22-nucleotide single-stranded noncoding RNA that contributes to post-transcriptional modulation of gene expression. miRNA targeting therapy has been suggested to be useful for the treatment of cancers and other diseases. Gene knockout and miRNA targeting therapy have been demonstrated to improve SLE disease activity in mice. However, these approaches have not yet reached the level of clinical application. miRNA targeting therapy is limited by the fact that each miRNA has multiple targets. In addition, the expression of certain miRNAs may differ among cell tissues within a single SLE patient. This limitation can be overcome by targeted delivery and chemical modifications. In the future, further research into miRNA chemical modifications and delivery systems will help us develop novel therapeutic agents for SLE.
キーワード systemic lupus erythematosus miRNA miRNA targeting therapy
Amo Type Review
出版物タイトル Acta Medica Okayama
発行日 2022-08
76巻
4号
出版者 Okayama University Medical School
開始ページ 359
終了ページ 371
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 36123150
Web of Science KeyUT 000882167300002
フルテキストURL fulltext.pdf
著者 Fujiwara, Tomohiro| Nakata, Eiji| Kunisada, Toshiyuki| Ozaki, Toshifumi| Kawai, Akira|
キーワード Alveolar soft part sarcoma Survival Surgery Chemotherapy Pazopanib
発行日 2022-08-15
出版物タイトル BMC Cancer
22巻
1号
出版者 BMC
開始ページ 891
ISSN 1471-2407
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2022.
論文のバージョン publisher
PubMed ID 35971085
DOI 10.1186/s12885-022-09968-5
Web of Science KeyUT 000840842400002
関連URL isVersionOf https://doi.org/10.1186/s12885-022-09968-5
フルテキストURL fulltext.pdf
著者 Mizoguchi, Haruki| Kamada, Hidetoshi| Morimoto, Kazuki| Yoshida, Ryuji| Sakakura, Akira|
発行日 2022-07-25
出版物タイトル Chemical Science
13巻
出版者 ROYAL SOC CHEMISTRY
開始ページ 9580
終了ページ 9585
ISSN 2041-6520
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 The Author(s).
論文のバージョン publisher
PubMed ID 36091886
DOI 10.1039/d2sc02623f
Web of Science KeyUT 000837413900001
関連URL isVersionOf https://doi.org/10.1039/d2sc02623f
フルテキストURL fulltext20220819-1.pdf
著者 Nakamura, Kazufumi| Miyoshi, Toru| Akagi, Satoshi| Toh, Norihisa| Saito, Yukihiro| Takaya, Yoichi| Yoshida, Masatoki| Nakagawa, Koji| Kawada, Satoshi| Toda, Hironobu| Miki, Takashi| Nakayama, Rie| Yokohama, Fumi| Ichikawa, Keishi| Yoshida, Masashi| Taniyama, Makiko| Nishii, Nobuhiro| Akagi, Teiji| Morita, Hiroshi| Ito, Hiroshi|
キーワード Cardiology Heart failure Internationalization
発行日 2022-7-25
出版物タイトル Circulation Journal
86巻
8号
出版者 Japanese Circulation Society
開始ページ 1312
終了ページ 1318
ISSN 1346-9843
NCID AA11591968
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン publisher
PubMed ID 35768227
DOI 10.1253/circj.cj-22-0349
Web of Science KeyUT 000835874200019
関連URL https://doi.org/10.1253/circj.cj-22-0349
フルテキストURL fulltext.pdf
著者 Tokumasu, Kazuki| Honda, Hiroyuki| Sunada, Naruhiko| Sakurada, Yasue| Matsuda, Yui| Yamamoto, Koichiro| Nakano, Yasuhiro| Hasegawa, Toru| Yamamoto, Yukichika| Otsuka, Yuki| Hagiya, Hideharu| Kataoka, Hitomi| Ueda, Keigo| Otsuka, Fumio|
キーワード general fatigue post-exertional malaise long COVID myalgic encephalomyelitis chronic fatigue syndrome post COVID-19 condition
発行日 2022-06-25
出版物タイトル Medicina
58巻
7号
出版者 MDPI
開始ページ 850
ISSN 1010-660X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 by the authors.
論文のバージョン publisher
PubMed ID 35888568
DOI 10.3390/medicina58070850
Web of Science KeyUT 000834490500001
関連URL isVersionOf https://doi.org/10.3390/medicina58070850
タイトル(別表記) First and second excavation report of Iwabushi site in Tottori prefecture
フルテキストURL fulltext20220809.pdf
著者 松本 直子|
抄録 主な遺跡は縄文時代早期押型文土器、縄文時代後期の土器・石器。縄文早期の地表面を確認、黒ボク層中で土器集中部を検出。
発行日 2016-03-25
言語 日本語
論文のバージョン publisher
ライセンス https://creativecommons.org/licenses/by/4.0/
フルテキストURL fulltext.pdf
著者 Mitalo, Oscar W.| Asiche, William O.| Kang, Seung W.| Ezura, Hiroshi| Akagi, Takashi| Kubo, Yasutaka| Ushijima, Koichiro|
キーワード chlorophyll citrus degreening ethylene RNA-Seq on-tree storage
発行日 2022-07-13
出版物タイトル Frontiers In Plant Science
13巻
出版者 Frontiers Media SA
開始ページ 918226
ISSN 1664-462X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 Mitalo, Asiche, Kang, Ezura, Akagi, Kubo and Ushijima.
論文のバージョン publisher
PubMed ID 35909736
DOI 10.3389/fpls.2022.918226
Web of Science KeyUT 000832990000001
関連URL isVersionOf https://doi.org/10.3389/fpls.2022.918226
フルテキストURL fulltext.pdf
著者 Kashimoto, Rena| Furukawa, Saya| Yamamoto, Sakiya| Kamei, Yasuhiro| Sakamoto, Joe| Nonaka, Shigenori| Watanabe, Tomonobu M.| Sakamoto, Tatsuya| Sakamoto, Hirotaka| Satoh, Akira|
発行日 2022-07-15
出版物タイトル iScience
25巻
7号
出版者 CELL PRESS
開始ページ 104524
ISSN 2589-0042
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 The Author(s).
論文のバージョン publisher
PubMed ID 35754731
DOI 10.1016/j.isci.2022.104524
Web of Science KeyUT 000828186100005
関連URL isVersionOf https://doi.org/10.1016/j.isci.2022.104524
フルテキストURL fulltext.pdf
著者 Iwamuro, Masaya| Tanaka, Takehiro| Kuraoka, Sakiko| Hamada, Kenta| Abe, Makoto| Kono, Yoshiyasu| Kanzaki, Hiromitsu| Kawano, Seiji| Kawahara, Yoshiro| Okada, Hiroyuki|
キーワード esophagogastroduodenoscopy gastric erosion gastric ulcer zinc acetate dihydrate
発行日 2022-07-01
出版物タイトル Internal Medicine
61巻
13号
出版者 The Japanese Society of Internal Medicine
開始ページ 1931
終了ページ 1938
ISSN 0918-2918
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 The Japanese Society of Internal Medicine
論文のバージョン publisher
PubMed ID 35781269
DOI 10.2169/internalmedicine.8625-21
Web of Science KeyUT 000823060200001
関連URL isVersionOf https://doi.org/10.2169/internalmedicine.8625-21
フルテキストURL fulltext.pdf
著者 Kametaka, Daisuke| Iwamuro, Masaya| Takahashi, Takahide| Hirabata, Araki| Hamada, Kenta| Kono, Yoshiyasu| Kanzaki, Hiromitsu| Kawano, Seiji| Tanaka, Takehiro| Otsuka, Fumio| Kawahara, Yoshiro| Okada, Hiroyuki|
キーワード flow cytometry autoimmune gastritis atrophic gastritis Helicobacter pylori
発行日 2022-05-25
出版物タイトル Current Issues In Molecular Biology
44巻
6号
出版者 MDPI
開始ページ 2443
終了ページ 2452
ISSN 1467-3037
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 by the authors.
論文のバージョン publisher
PubMed ID 35735608
DOI 10.3390/cimb44060167
Web of Science KeyUT 000816477400001
関連URL isVersionOf https://doi.org/10.3390/cimb44060167
JaLCDOI 10.18926/AMO/63740
フルテキストURL 76_3_307.pdf
著者 Sugiura, Satoshi| Kitamura, Yoshihisa| Izushi, Yasuhisa| Ushio, Soichiro| Sendo, Toshiaki|
抄録 In recent years, medical staff including physicians and nurses have been participating in home health care, reflecting the needs of an aging society in Japan. Pharmacists are also asked to work on home health care teams to ensure the medical safety of patients. It currently remains unclear whether direct communication, i.e. a meeting, between home-visiting physicians and pharmacists contributes to the proper use of medications and continuous medical care. We retrospectively analyzed the medication management guidance records of home-visited patients who received their first home visit between April 2014 and March 2017. We collected data on pharmacist inquiries, the duration of visits, and details from a meeting between home-visiting physicians and pharmacists. Thirty-five patients were included. At the first visit, the inquiry rate by pharmacists was 65.7%. The prescription question rate was significantly lower in patients with a meeting than in those without (p=0.033). The average duration of visits was significantly shorter for home-visited patients whose health care providers had a meeting (p=0.007). These results suggest that pharmacists who held a meeting with the home-visiting physician before the first patient visit were able to resolve drug-related issues earlier, which increased the work efficiency of home-visiting pharmacists.
キーワード home visit pharmacist meeting inquiry home health care
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-06
76巻
3号
出版者 Okayama University Medical School
開始ページ 307
終了ページ 315
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 35790361
Web of Science KeyUT 000823568300001
JaLCDOI 10.18926/AMO/63738
フルテキストURL 76_3_291.pdf
著者 Miyake, Yoshiaki| Mitani, Shigeru| Namba, Yoshifumi| Umehara, Norifumi| Kawamoto, Toyohiro| Furuichi, Shuro|
抄録 Total hip arthroplasty (THA) provides relief from hip pain and improves hip function. However, periprosthetic joint infection (PJI) remains an area of concern. We examined the detection rate of bacteria from surgical fields in wound closure, along with the relationship between bacterial detection rate and type of antiseptic, surgery time, and surgeon experience for 500 patients who underwent THA at our department. The mean age at surgery was 64.3 (± 27.3) years. The bacterial detection rate was 4.6%. None of the cases revealed PJI. No significant association between the detection rate and type of antiseptic used or surgery time was observed. However, for patients treated by surgeons with < 10 years of orthopedic experience, a detection rate of 7.3% was found, while a rate of 1.3% was observed for those treated by surgeons with ≥ 10 years of orthopedic experience. This finding indicated that orthopedic experience of less than 10 years was significantly associated with an increased bacterial detection rate (chi-square test, p=0.002). The detection rate was associated with surgeon experience but not with antiseptic type or surgery time. It is possible that intraoperative handling may increase the number of bacteria in surgical fields in wound closure.
キーワード total hip arthroplasty bacterial contamination periprosthetic joint infection
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-06
76巻
3号
出版者 Okayama University Medical School
開始ページ 291
終了ページ 295
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 35790359
Web of Science KeyUT 000823568300008
フルテキストURL fulltext20220630-4.pdf
著者 Kato, Kosaku| Uemura, Yohei| Asakura, Kiyotaka| Yamakata, Akira|
備考 This document is the Accepted Manuscript version of a Published Work that appeared in final form in The Journal of Physical Chemistry C, copyright © 2022 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.jpcc.2c01662
This fulltext is available in May 2023.|
発行日 2022-05-25
出版物タイトル The Journal of Physical Chemistry C
126巻
22号
出版者 American Chemical Society
開始ページ 9257
終了ページ 9263
ISSN 1932-7447
NCID AA1217589X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 American Chemical Society
論文のバージョン author
DOI 10.1021/acs.jpcc.2c01662
Web of Science KeyUT 000810253900001
関連URL isVersionOf https://doi.org/10.1021/acs.jpcc.2c01662
フルテキストURL fulltext20220620-4.pdf
著者 Ren, Jianchao| Kaneta, Takashi|
備考 This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s44211-022-00078-7
This fulltext is available in Feb. 2023.|
発行日 2022-02-25
出版物タイトル Analytical Sciences
38巻
4号
出版者 Springer Science and Business Media LLC
開始ページ 651
終了ページ 655
ISSN 0910-6340
NCID AA10500785
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022. The Author(s), under exclusive licence to The Japan Society for Analytical Chemistry.
論文のバージョン author
PubMed ID 35286641
DOI 10.1007/s44211-022-00078-7
Web of Science KeyUT 000808551700004
関連URL isVersionOf https://doi.org/10.1007/s44211-022-00078-7
JaLCDOI 10.18926/AMO/63719
フルテキストURL 76_3_255.pdf
著者 Nakatsuka, Kosuke| Matsuoka, Yoshikazu| Kurita, Masako| Wang, Ruilin| Tsuboi, Chika| Sue, Nobutaka| Kaku, Ryuji| Morimatsu, Hiroshi|
抄録 Mirror image pain (MIP) is a type of extraterritorial pain that results in contralateral pain or allodynia. Glutamate transporter-1 (GLT-1) is expressed in astrocytes and plays a role in maintaining low glutamate levels in the synaptic cleft. Previous studies have shown that GLT-1 dysfunction induces neuropathic pain. Our previous study revealed bilateral GLT-1 downregulation in the spinal cord of a spared nerve injury (SNI) rat. We hypothesized that spinal GLT-1 is involved in the mechanism of MIP. We also previously demonstrated noradrenergic GLT-1 regulation. Therefore, this study aimed to investigate the effect of an α1 adrenergic antagonist on the development of MIP. Rats were subjected to SNI. Changes in pain behavior and GLT-1 protein levels in the SNI rat spinal cords were then examined by intrathecal administration of the α1 adrenergic antagonist phentolamine, followed by von Frey test and western blotting. SNI resulted in the development of MIP and bilateral downregulation of GLT-1 protein in the rat spinal cord. Intrathecal phentolamine increased contralateral GLT-1 protein levels and partially ameliorated the 50% paw withdrawal threshold in the contralateral hind paw. Spinal GLT-1 upregulation by intrathecal phentolamine ameliorates MIP. GLT-1 plays a role in the development of MIPs.
キーワード alpha adrenergic receptor glutamate transporter-1 mirror image pain neuropathic pain spared nerve injury
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-06
76巻
3号
出版者 Okayama University Medical School
開始ページ 255
終了ページ 263
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 35790355
Web of Science KeyUT 000823568300004
JaLCDOI 10.18926/AMO/63718
フルテキストURL 76_3_247.pdf
著者 Yoshida, Shohei| Fujii, Nobuharu| Kamoi, Chihiro| Kitamura, Wataru| Fujiwara, Hideaki| Asada, Noboru| Nishimori, Hisakazu| Fujii, Keiko| Matsuoka, Ken-ichi| Maeda, Yoshinobu|
抄録 Vaccine-preventable disease (VPD) infections are more severe in immunocompromised hosts. Vaccination against measles, mumps, rubella, and varicella zoster (VZV) (MMRV) is therefore recommended for hematopoietic stem cell transplantation (HCT) recipients. However, studies on adult HCT recipients with VPD infections are limited. At our institution, we have systematically conducted serological MMRV tests as a part of check-up examinations during long-term follow-up (LTFU) after HCT since 2015. This retrospective study aimed to evaluate changes in the serostatus between before and 2 years after allogeneic HCT. Among 161 patients, the pre-transplant seropositivity was 82.7% for measles, 86.8% for mumps, 84.2% for rubella, and 94.3% for VZV. Among 56 patients who underwent LTFU including serological MMRV tests at 2 years after HCT, the percentages maintaining seroprotective antibody levels for measles, mumps, rubella and VZV were 71.5% (40/56), 51.8% (29/56), 48.2% (27/56), and 60.7% (34/56), respectively. Vaccination was recommended for 22 patients, and 12 were vaccinated. Among the 12 vaccinated patients, rates of seroconversion were examined in 2-6 patients for each of the four viruses. They were 100% (3/3) for measles, 33.3% (1/3) for mumps, 50% (3/6) for rubella, and 0% (0/2) for VZV. Further studies are warranted to clarify the effect of vaccination in adult HCT recipients.
キーワード vaccine-preventable disease vaccination allogeneic hematopoietic stem cell transplantation adult
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-06
76巻
3号
出版者 Okayama University Medical School
開始ページ 247
終了ページ 253
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 35790354
Web of Science KeyUT 000823568300003
フルテキストURL fulltext.pdf
著者 Iwamuro, Masaya| Kusumoto, Chiaki| Nakagawa, Masahiro| Matsueda, Kazuhiro| Kobayashi, Sayo| Yoshioka, Masao| Inaba, Tomoki| Toyokawa, Tatsuya| Sakaguchi, Chihiro| Tanaka, Shouichi| Tanaka, Takehiro| Okada, Hiroyuki|
キーワード Gastric neoplasms Oxyntic gland adenoma Gastric adenocarcinoma of the fundic gland type
発行日 2022-06-12
出版物タイトル BMC Gastroenterology
22巻
1号
出版者 BMC
開始ページ 294
ISSN 1471-230X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2022.
論文のバージョン publisher
PubMed ID 35692036
DOI 10.1186/s12876-022-02368-w
Web of Science KeyUT 000809663500001
関連URL isVersionOf https://doi.org/10.1186/s12876-022-02368-w
フルテキストURL fulltext.pdf
著者 Fuji, Tomokazu| Umeda, Yuzo| Takagi, Kosei| Yoshida, Ryuichi| Yoshida, Kazuhiro| Yasui, Kazuya| Matsumoto, Kazuyuki| Kato, Hironari| Yagi, Takahito| Fujiwara, Toshiyoshi|
キーワード Pancreatic intraductal neoplasms Pancreatectomy Recurrence
発行日 2022-05-29
出版物タイトル BMC Cancer
22巻
1号
出版者 BMC
開始ページ 588
ISSN 1471-2407
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2022.
論文のバージョン publisher
PubMed ID 35643422
DOI 10.1186/s12885-022-09650-w
Web of Science KeyUT 000801165400001
関連URL isVersionOf https://doi.org/10.1186/s12885-022-09650-w
フルテキストURL fulltext.pdf
著者 Ugawa, Satoko| Akagi, Satoshi| Ejiri, Kentaro| Nakamura, Kazufumi| Ito, Hiroshi|
キーワード pulmonary vascular bed pulmonary arterial hypertension lung perfusion scintigraphy
発行日 2022-05-05
出版物タイトル Life-Basel
12巻
5号
出版者 MDPI
開始ページ 684
ISSN 2075-1729
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 by the authors.
論文のバージョン publisher
PubMed ID 35629352
DOI 10.3390/life12050684
Web of Science KeyUT 000801579500001
関連URL isVersionOf https://doi.org/10.3390/life12050684