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JaLCDOI 10.18926/AMO/63896
FullText URL 76_4_415.pdf
Author Kang, Haijun| Huang, Dongmei| Kang, Gangjin| Yang, Xu| Li, Heng| Liu, Siyuan| Gou, Wenjun| Liu, Linglin| Qiu, Yuyan|
Abstract Posterior capsule opacification (PCO) is a post-surgery complication of cataract surgery, and lens epithelial cells (LECs) are involved in its development. A suppressive effect on LECs is exerted by the non specific chloride channel inhibitor 5-nitro-2-(3-phenylpropylamino) benzoic acid (NPPB) exerts. Herein, the growth and migration inhibitory effects of NPPB on LECs were assessed, and the mechanism underlying the effects were investigated by focusing on Ca2+/CaMKII signaling. LECs were treated with different concentrations of NPPB, and the changes in cell viability, cell-cycle distribution, anchorage-dependent growth, migration, Ca2+ level, and CaMKII expression were evaluated. NPPB inhibited LECs’ proliferation and induced G1 cell-cycle arrest in the cells. Regarding LECs’ mobility, NPPB suppressed the cells’ anchorage-dependent growth ability and inhibited their migration. Changes in cell phenotypes were associated with an increased intracellular Ca2+ level and down-regulation of CaMKII. Together these results confirmed the inhibitory effect of NPPB on the proliferation and migration of LECs, and the effect was shown to be associated with the induced level of Ca2+ and the inhibition of CaMKII signaling transduction.
Keywords 5-nitro-2-(3-phenylpropylamino) benzoic acid CaMKII lens epithelial cell migration proliferation
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 415
End Page 421
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123156
Web of Science KeyUT 000882167300007
JaLCDOI 10.18926/AMO/63887
FullText URL 76_4_359.pdf
Author Hiramatsu-Asano, Sumie| Wada, Jun|
Abstract Systemic lupus erythematosus (SLE) is a potentially fatal systemic autoimmune disease, and its etiology involves both genetic and environmental factors such as sex hormone imbalance, genetic predisposition, epigenetic regulation, and immunological factors. Dysregulation of microRNA (miRNA) is suggested to be one of the epigenetic factors in SLE. miRNA is a 22-nucleotide single-stranded noncoding RNA that contributes to post-transcriptional modulation of gene expression. miRNA targeting therapy has been suggested to be useful for the treatment of cancers and other diseases. Gene knockout and miRNA targeting therapy have been demonstrated to improve SLE disease activity in mice. However, these approaches have not yet reached the level of clinical application. miRNA targeting therapy is limited by the fact that each miRNA has multiple targets. In addition, the expression of certain miRNAs may differ among cell tissues within a single SLE patient. This limitation can be overcome by targeted delivery and chemical modifications. In the future, further research into miRNA chemical modifications and delivery systems will help us develop novel therapeutic agents for SLE.
Keywords systemic lupus erythematosus miRNA miRNA targeting therapy
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 359
End Page 371
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123150
Web of Science KeyUT 000882167300002
FullText URL fulltext.pdf
Author Fujiwara, Tomohiro| Nakata, Eiji| Kunisada, Toshiyuki| Ozaki, Toshifumi| Kawai, Akira|
Keywords Alveolar soft part sarcoma Survival Surgery Chemotherapy Pazopanib
Published Date 2022-08-15
Publication Title BMC Cancer
Volume volume22
Issue issue1
Publisher BMC
Start Page 891
ISSN 1471-2407
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022.
File Version publisher
PubMed ID 35971085
DOI 10.1186/s12885-022-09968-5
Web of Science KeyUT 000840842400002
Related Url isVersionOf https://doi.org/10.1186/s12885-022-09968-5
FullText URL fulltext.pdf
Author Mizoguchi, Haruki| Kamada, Hidetoshi| Morimoto, Kazuki| Yoshida, Ryuji| Sakakura, Akira|
Published Date 2022-07-25
Publication Title Chemical Science
Volume volume13
Publisher ROYAL SOC CHEMISTRY
Start Page 9580
End Page 9585
ISSN 2041-6520
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Author(s).
File Version publisher
PubMed ID 36091886
DOI 10.1039/d2sc02623f
Web of Science KeyUT 000837413900001
Related Url isVersionOf https://doi.org/10.1039/d2sc02623f
FullText URL fulltext20220819-1.pdf
Author Nakamura, Kazufumi| Miyoshi, Toru| Akagi, Satoshi| Toh, Norihisa| Saito, Yukihiro| Takaya, Yoichi| Yoshida, Masatoki| Nakagawa, Koji| Kawada, Satoshi| Toda, Hironobu| Miki, Takashi| Nakayama, Rie| Yokohama, Fumi| Ichikawa, Keishi| Yoshida, Masashi| Taniyama, Makiko| Nishii, Nobuhiro| Akagi, Teiji| Morita, Hiroshi| Ito, Hiroshi|
Keywords Cardiology Heart failure Internationalization
Published Date 2022-7-25
Publication Title Circulation Journal
Volume volume86
Issue issue8
Publisher Japanese Circulation Society
Start Page 1312
End Page 1318
ISSN 1346-9843
NCID AA11591968
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 35768227
DOI 10.1253/circj.cj-22-0349
Web of Science KeyUT 000835874200019
Related Url https://doi.org/10.1253/circj.cj-22-0349
FullText URL fulltext.pdf
Author Tokumasu, Kazuki| Honda, Hiroyuki| Sunada, Naruhiko| Sakurada, Yasue| Matsuda, Yui| Yamamoto, Koichiro| Nakano, Yasuhiro| Hasegawa, Toru| Yamamoto, Yukichika| Otsuka, Yuki| Hagiya, Hideharu| Kataoka, Hitomi| Ueda, Keigo| Otsuka, Fumio|
Keywords general fatigue post-exertional malaise long COVID myalgic encephalomyelitis chronic fatigue syndrome post COVID-19 condition
Published Date 2022-06-25
Publication Title Medicina
Volume volume58
Issue issue7
Publisher MDPI
Start Page 850
ISSN 1010-660X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 35888568
DOI 10.3390/medicina58070850
Web of Science KeyUT 000834490500001
Related Url isVersionOf https://doi.org/10.3390/medicina58070850
Title Alternative First and second excavation report of Iwabushi site in Tottori prefecture
FullText URL fulltext20220809.pdf
Author Matsumoto, Naoko|
Abstract 主な遺跡は縄文時代早期押型文土器、縄文時代後期の土器・石器。縄文早期の地表面を確認、黒ボク層中で土器集中部を検出。
Published Date 2016-03-25
language Japanese
File Version publisher
License https://creativecommons.org/licenses/by/4.0/
FullText URL fulltext.pdf
Author Mitalo, Oscar W.| Asiche, William O.| Kang, Seung W.| Ezura, Hiroshi| Akagi, Takashi| Kubo, Yasutaka| Ushijima, Koichiro|
Keywords chlorophyll citrus degreening ethylene RNA-Seq on-tree storage
Published Date 2022-07-13
Publication Title Frontiers In Plant Science
Volume volume13
Publisher Frontiers Media SA
Start Page 918226
ISSN 1664-462X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Mitalo, Asiche, Kang, Ezura, Akagi, Kubo and Ushijima.
File Version publisher
PubMed ID 35909736
DOI 10.3389/fpls.2022.918226
Web of Science KeyUT 000832990000001
Related Url isVersionOf https://doi.org/10.3389/fpls.2022.918226
FullText URL fulltext.pdf
Author Kashimoto, Rena| Furukawa, Saya| Yamamoto, Sakiya| Kamei, Yasuhiro| Sakamoto, Joe| Nonaka, Shigenori| Watanabe, Tomonobu M.| Sakamoto, Tatsuya| Sakamoto, Hirotaka| Satoh, Akira|
Published Date 2022-07-15
Publication Title iScience
Volume volume25
Issue issue7
Publisher CELL PRESS
Start Page 104524
ISSN 2589-0042
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Author(s).
File Version publisher
PubMed ID 35754731
DOI 10.1016/j.isci.2022.104524
Web of Science KeyUT 000828186100005
Related Url isVersionOf https://doi.org/10.1016/j.isci.2022.104524
FullText URL fulltext.pdf
Author Iwamuro, Masaya| Tanaka, Takehiro| Kuraoka, Sakiko| Hamada, Kenta| Abe, Makoto| Kono, Yoshiyasu| Kanzaki, Hiromitsu| Kawano, Seiji| Kawahara, Yoshiro| Okada, Hiroyuki|
Keywords esophagogastroduodenoscopy gastric erosion gastric ulcer zinc acetate dihydrate
Published Date 2022-07-01
Publication Title Internal Medicine
Volume volume61
Issue issue13
Publisher The Japanese Society of Internal Medicine
Start Page 1931
End Page 1938
ISSN 0918-2918
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Japanese Society of Internal Medicine
File Version publisher
PubMed ID 35781269
DOI 10.2169/internalmedicine.8625-21
Web of Science KeyUT 000823060200001
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.8625-21
FullText URL fulltext.pdf
Author Kametaka, Daisuke| Iwamuro, Masaya| Takahashi, Takahide| Hirabata, Araki| Hamada, Kenta| Kono, Yoshiyasu| Kanzaki, Hiromitsu| Kawano, Seiji| Tanaka, Takehiro| Otsuka, Fumio| Kawahara, Yoshiro| Okada, Hiroyuki|
Keywords flow cytometry autoimmune gastritis atrophic gastritis Helicobacter pylori
Published Date 2022-05-25
Publication Title Current Issues In Molecular Biology
Volume volume44
Issue issue6
Publisher MDPI
Start Page 2443
End Page 2452
ISSN 1467-3037
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 35735608
DOI 10.3390/cimb44060167
Web of Science KeyUT 000816477400001
Related Url isVersionOf https://doi.org/10.3390/cimb44060167
JaLCDOI 10.18926/AMO/63740
FullText URL 76_3_307.pdf
Author Sugiura, Satoshi| Kitamura, Yoshihisa| Izushi, Yasuhisa| Ushio, Soichiro| Sendo, Toshiaki|
Abstract In recent years, medical staff including physicians and nurses have been participating in home health care, reflecting the needs of an aging society in Japan. Pharmacists are also asked to work on home health care teams to ensure the medical safety of patients. It currently remains unclear whether direct communication, i.e. a meeting, between home-visiting physicians and pharmacists contributes to the proper use of medications and continuous medical care. We retrospectively analyzed the medication management guidance records of home-visited patients who received their first home visit between April 2014 and March 2017. We collected data on pharmacist inquiries, the duration of visits, and details from a meeting between home-visiting physicians and pharmacists. Thirty-five patients were included. At the first visit, the inquiry rate by pharmacists was 65.7%. The prescription question rate was significantly lower in patients with a meeting than in those without (p=0.033). The average duration of visits was significantly shorter for home-visited patients whose health care providers had a meeting (p=0.007). These results suggest that pharmacists who held a meeting with the home-visiting physician before the first patient visit were able to resolve drug-related issues earlier, which increased the work efficiency of home-visiting pharmacists.
Keywords home visit pharmacist meeting inquiry home health care
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-06
Volume volume76
Issue issue3
Publisher Okayama University Medical School
Start Page 307
End Page 315
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35790361
Web of Science KeyUT 000823568300001
JaLCDOI 10.18926/AMO/63738
FullText URL 76_3_291.pdf
Author Miyake, Yoshiaki| Mitani, Shigeru| Namba, Yoshifumi| Umehara, Norifumi| Kawamoto, Toyohiro| Furuichi, Shuro|
Abstract Total hip arthroplasty (THA) provides relief from hip pain and improves hip function. However, periprosthetic joint infection (PJI) remains an area of concern. We examined the detection rate of bacteria from surgical fields in wound closure, along with the relationship between bacterial detection rate and type of antiseptic, surgery time, and surgeon experience for 500 patients who underwent THA at our department. The mean age at surgery was 64.3 (± 27.3) years. The bacterial detection rate was 4.6%. None of the cases revealed PJI. No significant association between the detection rate and type of antiseptic used or surgery time was observed. However, for patients treated by surgeons with < 10 years of orthopedic experience, a detection rate of 7.3% was found, while a rate of 1.3% was observed for those treated by surgeons with ≥ 10 years of orthopedic experience. This finding indicated that orthopedic experience of less than 10 years was significantly associated with an increased bacterial detection rate (chi-square test, p=0.002). The detection rate was associated with surgeon experience but not with antiseptic type or surgery time. It is possible that intraoperative handling may increase the number of bacteria in surgical fields in wound closure.
Keywords total hip arthroplasty bacterial contamination periprosthetic joint infection
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-06
Volume volume76
Issue issue3
Publisher Okayama University Medical School
Start Page 291
End Page 295
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35790359
Web of Science KeyUT 000823568300008
FullText URL fulltext20220630-4.pdf
Author Kato, Kosaku| Uemura, Yohei| Asakura, Kiyotaka| Yamakata, Akira|
Note This document is the Accepted Manuscript version of a Published Work that appeared in final form in The Journal of Physical Chemistry C, copyright © 2022 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.jpcc.2c01662
This fulltext is available in May 2023.|
Published Date 2022-05-25
Publication Title The Journal of Physical Chemistry C
Volume volume126
Issue issue22
Publisher American Chemical Society
Start Page 9257
End Page 9263
ISSN 1932-7447
NCID AA1217589X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 American Chemical Society
File Version author
DOI 10.1021/acs.jpcc.2c01662
Web of Science KeyUT 000810253900001
Related Url isVersionOf https://doi.org/10.1021/acs.jpcc.2c01662
FullText URL fulltext20220620-4.pdf
Author Ren, Jianchao| Kaneta, Takashi|
Note This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s44211-022-00078-7
This fulltext is available in Feb. 2023.|
Published Date 2022-02-25
Publication Title Analytical Sciences
Volume volume38
Issue issue4
Publisher Springer Science and Business Media LLC
Start Page 651
End Page 655
ISSN 0910-6340
NCID AA10500785
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022. The Author(s), under exclusive licence to The Japan Society for Analytical Chemistry.
File Version author
PubMed ID 35286641
DOI 10.1007/s44211-022-00078-7
Web of Science KeyUT 000808551700004
Related Url isVersionOf https://doi.org/10.1007/s44211-022-00078-7
JaLCDOI 10.18926/AMO/63719
FullText URL 76_3_255.pdf
Author Nakatsuka, Kosuke| Matsuoka, Yoshikazu| Kurita, Masako| Wang, Ruilin| Tsuboi, Chika| Sue, Nobutaka| Kaku, Ryuji| Morimatsu, Hiroshi|
Abstract Mirror image pain (MIP) is a type of extraterritorial pain that results in contralateral pain or allodynia. Glutamate transporter-1 (GLT-1) is expressed in astrocytes and plays a role in maintaining low glutamate levels in the synaptic cleft. Previous studies have shown that GLT-1 dysfunction induces neuropathic pain. Our previous study revealed bilateral GLT-1 downregulation in the spinal cord of a spared nerve injury (SNI) rat. We hypothesized that spinal GLT-1 is involved in the mechanism of MIP. We also previously demonstrated noradrenergic GLT-1 regulation. Therefore, this study aimed to investigate the effect of an α1 adrenergic antagonist on the development of MIP. Rats were subjected to SNI. Changes in pain behavior and GLT-1 protein levels in the SNI rat spinal cords were then examined by intrathecal administration of the α1 adrenergic antagonist phentolamine, followed by von Frey test and western blotting. SNI resulted in the development of MIP and bilateral downregulation of GLT-1 protein in the rat spinal cord. Intrathecal phentolamine increased contralateral GLT-1 protein levels and partially ameliorated the 50% paw withdrawal threshold in the contralateral hind paw. Spinal GLT-1 upregulation by intrathecal phentolamine ameliorates MIP. GLT-1 plays a role in the development of MIPs.
Keywords alpha adrenergic receptor glutamate transporter-1 mirror image pain neuropathic pain spared nerve injury
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-06
Volume volume76
Issue issue3
Publisher Okayama University Medical School
Start Page 255
End Page 263
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35790355
Web of Science KeyUT 000823568300004
JaLCDOI 10.18926/AMO/63718
FullText URL 76_3_247.pdf
Author Yoshida, Shohei| Fujii, Nobuharu| Kamoi, Chihiro| Kitamura, Wataru| Fujiwara, Hideaki| Asada, Noboru| Nishimori, Hisakazu| Fujii, Keiko| Matsuoka, Ken-ichi| Maeda, Yoshinobu|
Abstract Vaccine-preventable disease (VPD) infections are more severe in immunocompromised hosts. Vaccination against measles, mumps, rubella, and varicella zoster (VZV) (MMRV) is therefore recommended for hematopoietic stem cell transplantation (HCT) recipients. However, studies on adult HCT recipients with VPD infections are limited. At our institution, we have systematically conducted serological MMRV tests as a part of check-up examinations during long-term follow-up (LTFU) after HCT since 2015. This retrospective study aimed to evaluate changes in the serostatus between before and 2 years after allogeneic HCT. Among 161 patients, the pre-transplant seropositivity was 82.7% for measles, 86.8% for mumps, 84.2% for rubella, and 94.3% for VZV. Among 56 patients who underwent LTFU including serological MMRV tests at 2 years after HCT, the percentages maintaining seroprotective antibody levels for measles, mumps, rubella and VZV were 71.5% (40/56), 51.8% (29/56), 48.2% (27/56), and 60.7% (34/56), respectively. Vaccination was recommended for 22 patients, and 12 were vaccinated. Among the 12 vaccinated patients, rates of seroconversion were examined in 2-6 patients for each of the four viruses. They were 100% (3/3) for measles, 33.3% (1/3) for mumps, 50% (3/6) for rubella, and 0% (0/2) for VZV. Further studies are warranted to clarify the effect of vaccination in adult HCT recipients.
Keywords vaccine-preventable disease vaccination allogeneic hematopoietic stem cell transplantation adult
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-06
Volume volume76
Issue issue3
Publisher Okayama University Medical School
Start Page 247
End Page 253
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35790354
Web of Science KeyUT 000823568300003
FullText URL fulltext.pdf
Author Iwamuro, Masaya| Kusumoto, Chiaki| Nakagawa, Masahiro| Matsueda, Kazuhiro| Kobayashi, Sayo| Yoshioka, Masao| Inaba, Tomoki| Toyokawa, Tatsuya| Sakaguchi, Chihiro| Tanaka, Shouichi| Tanaka, Takehiro| Okada, Hiroyuki|
Keywords Gastric neoplasms Oxyntic gland adenoma Gastric adenocarcinoma of the fundic gland type
Published Date 2022-06-12
Publication Title BMC Gastroenterology
Volume volume22
Issue issue1
Publisher BMC
Start Page 294
ISSN 1471-230X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022.
File Version publisher
PubMed ID 35692036
DOI 10.1186/s12876-022-02368-w
Web of Science KeyUT 000809663500001
Related Url isVersionOf https://doi.org/10.1186/s12876-022-02368-w
FullText URL fulltext.pdf
Author Fuji, Tomokazu| Umeda, Yuzo| Takagi, Kosei| Yoshida, Ryuichi| Yoshida, Kazuhiro| Yasui, Kazuya| Matsumoto, Kazuyuki| Kato, Hironari| Yagi, Takahito| Fujiwara, Toshiyoshi|
Keywords Pancreatic intraductal neoplasms Pancreatectomy Recurrence
Published Date 2022-05-29
Publication Title BMC Cancer
Volume volume22
Issue issue1
Publisher BMC
Start Page 588
ISSN 1471-2407
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022.
File Version publisher
PubMed ID 35643422
DOI 10.1186/s12885-022-09650-w
Web of Science KeyUT 000801165400001
Related Url isVersionOf https://doi.org/10.1186/s12885-022-09650-w
FullText URL fulltext.pdf
Author Ugawa, Satoko| Akagi, Satoshi| Ejiri, Kentaro| Nakamura, Kazufumi| Ito, Hiroshi|
Keywords pulmonary vascular bed pulmonary arterial hypertension lung perfusion scintigraphy
Published Date 2022-05-05
Publication Title Life-Basel
Volume volume12
Issue issue5
Publisher MDPI
Start Page 684
ISSN 2075-1729
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 35629352
DOI 10.3390/life12050684
Web of Science KeyUT 000801579500001
Related Url isVersionOf https://doi.org/10.3390/life12050684