検索結果 471 件
| JaLCDOI | 10.18926/AMO/65496 |
|---|---|
| フルテキストURL | 77_3_311.pdf |
| 著者 | Miura, Takanori| Kijima, Hiroaki| Tazawa, Hiroshi| Miyakoshi, Naohisa| |
| 抄録 | Japan’s hip fracture management guidelines now recommend the use of cemented stems in cases of bone fragility. However, the current stem selection practices in bipolar hemiarthroplasty (BHA) in a super-aging area in Japan remain unclear. This study aimed to examine the stem selection policies, the surgeons’ concerns about cemented stems, and factors affecting their confidence in their ability to coach others on cemented stem procedures. Ninety-four orthopedic surgeons (27 facilities) responded to our web-based questionnaire conducted in January/February 2022. Cementless stem was the first choice of 97.8% of the surgeons; <15% of the respondents expected to increase their use of cemented stems in the future. The cement technique was the greatest concern; almost half of the surgeons described having insufficient experience with cemented stems. The factor that most affected the surgeons’ expertise in using cemented stems is the number of surgeries they had conducted with a cemented stem (multivariable analysis odds ratio 8.42, p=0.001). Greater experience was associated with increased expertise of the surgeons in using cemented stems, with a threshold of 11 cases showing sensitivity of 41.7% and specificity of 98.3% for their confidence to instruct cemented stems. |
| キーワード | hip fracture arthroplasty bone cement questionnaire |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-06 |
| 巻 | 77巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 311 |
| 終了ページ | 318 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 37357632 |
| Web of Science KeyUT | 001026279600009 |
| タイトル（別表記） | ERRATA: FDM simulation of long-period ground motions around Oita Prefecture, Japan, using a land-ocean unified 3D structure model |
|---|---|
| フルテキストURL | esr_029_065_066.pdf |
| 著者 | 奥仲 達也| 小松 正直| 竹中 博士| 吉見 雅行| 中村 武史| 岡元 太郎| |
| 出版物タイトル | Okayama University Earth Science Report |
| 発行日 | 2023-03-31 |
| 巻 | 29巻 |
| 号 | 1号 |
| 開始ページ | 65 |
| 終了ページ | 66 |
| ISSN | 1340-7414 |
| 言語 | 日本語 |
| 著作権者 | © 2023 by Okayama University Earth Science Reports Editorial Committee All Rights Reserved |
| 論文のバージョン | publisher |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Supitayakul, Parisa| Yücel, Zeynep | Monden, Akito| |
| キーワード | Visualization Electronic learning Task analysis Estimation Vocabulary Memory management Learning (artificial intelligence) E-learning neural networks artificial intelligence cognitive theory of multimedia learning cognitive load distinctiveness account perceptual decoupling adaptability educational data mining |
| 発行日 | 2023-04-13 |
| 出版物タイトル | IEEE Access |
| 巻 | 11巻 |
| 出版者 | Institute of Electrical and Electronics Engineers |
| 開始ページ | 39466 |
| 終了ページ | 39483 |
| ISSN | 2169-3536 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | publisher |
| DOI | 10.1109/ACCESS.2023.3266731 |
| Web of Science KeyUT | 000979583700001 |
| 関連URL | isVersionOf https://doi.org/10.1109/ACCESS.2023.3266731 |
| JaLCDOI | 10.18926/AMO/65144 |
|---|---|
| フルテキストURL | 77_2_147.pdf |
| 著者 | Arias, Zulema| Haines, Stephanie| Yamamoto, Tadashi| Hatanaka, Kazu| Yamashiro, Keisuke| Sonoi, Norihiro| Takashiba, Shogo| |
| 抄録 | The curriculum at the Department of Pathophysiology in the Periodontal Sciences program at Okayama University includes normative preclinical training (NPT) using phantoms. NPT is given to the whole class of 5 th year students divided in groups of 8 students/instructor. In 2019, an innovative personalized preclinical training (PPT) pilot study was implemented for this group of students whereby two students, each with their own dental unit, were coached by one instructor. The main topics covered were dental ergonomics and endodontics. We aimed to evaluate the effectiveness of PPT in dental ergonomics and endodontics toward increasing the knowledge and future clinical skills of students who had already undergone NPT. A test on endodontics was taken before and after PPT. A questionnaire was completed to assess their perception of improvement regarding the above-mentioned topics. Test scores and questionnaire results both showed that the students’ level of knowledge and awareness of future clinical skills was significantly higher after PPT. This pilot study demonstrated that PPT increased the students’ knowledge and future clinical skills. As preclinical training forms the foundation for clinical practice, investment in future research regarding this personalized approach is likely to enhance students’ understanding and clinical performance. |
| キーワード | preclinical personalized education dental ergonomics endodontics clinical skills improvement undergraduate students |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-04 |
| 巻 | 77巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 147 |
| 終了ページ | 159 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 37094952 |
| Web of Science KeyUT | 000982503800004 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Suzuki, Etsuji| Yamamoto, Eiji| |
| キーワード | attributable fraction counterfactual model excess fraction preventable fraction prevented fraction vaccine efficacy |
| 発行日 | 2023-02-24 |
| 出版物タイトル | Journal of Causal Inference |
| 巻 | 11巻 |
| 号 | 1号 |
| 出版者 | De Gruyter |
| ISSN | 2193-3677 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 the author(s) |
| 論文のバージョン | publisher |
| DOI | 10.1515/jci-2021-0068 |
| Web of Science KeyUT | 000938059600001 |
| 関連URL | isVersionOf https://doi.org/10.1515/jci-2021-0068 |
| JaLCDOI | 10.18926/AMO/64365 |
|---|---|
| フルテキストURL | 77_1_75.pdf |
| 著者 | Iwamuro, Masaya| Tanaka, Takehiro| Hamada, Kenta| Kono, Yoshiyasu| Kanzaki, Hiromitsu| Kawano, Seiji| Kawahara, Yoshiro| Okada, Hiroyuki| |
| 抄録 | Herein, we report two patients with autoimmune gastritis who had undergone multiple esophagogastroduodenoscopy procedures for 17 and 9 years, respectively, before their diagnosis. Instead, they had been diagnosed with and treated for Helicobacter pylori-associated gastritis. The correct diagnosis was made when scatterings of tiny whitish protrusions in the gastric mucosa were detected on esophagogastroduodenoscopy. Our findings suggest that scattered tiny whitish bumps may be a clue to the diagnosis of autoimmune gastritis. |
| キーワード | autoimmune gastritis esophagogastroduodenoscopy scattered lesions small white protrusions mucosal lesions |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-02 |
| 巻 | 77巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 75 |
| 終了ページ | 80 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36849149 |
| Web of Science KeyUT | 000952973200001 |
| JaLCDOI | 10.18926/AMO/64122 |
|---|---|
| フルテキストURL | 76_6_715.pdf |
| 著者 | Mohammed Zahedul Islam Nizami| Gorduysus, Melahat| Shinoda-Ito, Yuki| Yamamoto, Tadashi| Nishina, Yuta| Takashiba, Shogo| Arias, Zulema| |
| 抄録 | The failure of endodontic treatment is directly associated with microbial infection in the root canal or periapical areas. An endodontic sealer that is both bactericidal and biocompatible is essential for the success of root canal treatments. This is one of the vital issues yet to be solved in clinical dental practice. This in vitro study assessed the effectiveness of graphene oxide (GO) composites GO-CaF2 and GO-Ag-CaF2 as endodontic sealer materials. Dentin slices were coated with either the GO-based composites or commonly used root canal sealers (non-eugenol zinc oxide sealer). The coated slices were treated in 0.9% NaCl, phosphate-buffered saline (PBS), and simulated body fluid (SBF) at 37˚C for 24 hours to compare their sealing effect on the dentin surface. In addition, the radiopacity of these composites was examined to assess whether they complied with the requirements of a sealer for good radiographic visualization. Scanning electron microscopy showed the significant sealing capability of the composites as coating materials. Radiographic images confirmed their radiopacity. Mineral deposition indicated their bioactivity, especially of GO-Ag-CaF2, and thus it is potential for regenerative application. They were both previously shown to be bactericidal to oral microbes and cytocompatible with host cells. With such a unique assemblage of critical properties, these GO-based composites show promise as endodontic sealers for protection against reinfection in root canal treatment and enhanced success in endodontic treatment overall. |
| キーワード | bioactive sealer graphene oxide mineral deposition antimicrobial activity radiopacity |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 715 |
| 終了ページ | 721 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549774 |
| Web of Science KeyUT | 000905195100012 |
| JaLCDOI | 10.18926/AMO/64115 |
|---|---|
| フルテキストURL | 76_6_651.pdf |
| 著者 | Bright Osman Abugri| Matsusaki, Takashi| Ren, Wanxu| Morimatsu, Hiroshi| |
| 抄録 | Maintaining perioperative normothermia decreases the post-surgery surgical site infection (SSI) rate. We investigated whether SSI is associated with intraoperative hypothermia in total hip (THA) and total knee (TKA) arthroplasties by retrospectively analyzing 297 THA and TKA cases. The patients’ intraoperative core body temperature (BT) was measured by bladder catheter or forehead sensor. We evaluated the associations between SSI and intraoperative BT and other variables and patient characteristics. Fifty-six patients (18.8%) had hypothermia (BT <36°C); 43 developed SSI (14.5%); only five had hypothermia (11.6%). Intraoperative hypothermia and SSI were not significantly associated. The SSI group had more men (34.9% vs. 18.1%) and THA patients (77.4%), a longer mean surgical duration (174.3 vs. 143.5 mins), and a higher average BT (36.4°C vs. 36.2°C) than the no-SSI group. The SSI patients had a higher intraoperative BT. A multivariable analysis revealed that SSI was associated with male sex (OR 2.3, 95%CI: 1.031-4.921, p=0.042), longer surgery (OR, 1.01, 95%CI: 1.003-1.017, p=0.004), THA (OR 3.6, 95%CI: 1.258-10.085, p=0.017), and intraoperative BT >36.0°C (OR 3.6, 95%CI: 1.367-9.475, p=0.009). Intraoperative hypothermia was not associated with SSI in adults who underwent THA or TKA. These results suggest that hypothermia might not be the problem for SSI. |
| キーワード | hypothermia surgical site infection total hip arthroplasty (THA) knee arthroplasty (TKA) |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 651 |
| 終了ページ | 660 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549767 |
| Web of Science KeyUT | 000905195100005 |
| JaLCDOI | 10.18926/AMO/64111 |
|---|---|
| フルテキストURL | 76_6_617.pdf |
| 著者 | Kobayashi, Katsuhiro| Shibata, Takashi| Tsuchiya, Hiroki| Akiyama, Tomoyuki| |
| 抄録 | We developed an artificial intelligence (AI) technique to identify epileptic discharges (spikes) in pediatric scalp electroencephalograms (EEGs). We built a convolutional neural network (CNN) model to automatically classify steep potential images into spikes and background activity. For the CNN model’ training and validation, we examined 100 children with spikes in EEGs and another 100 without spikes. A different group of 20 children with spikes and 20 without spikes were the actual test subjects. All subjects were ≥ 3 to < 18 years old. The accuracy, sensitivity, and specificity of the analysis were >0.97 when referential and combination EEG montages were used, and < 0.97 with a bipolar montage. The correct classification of background activity in individual patients was significantly better with a referential montage than with a bipolar montage (p=0.0107). Receiver operating characteristic curves yielded an area under the curve > 0.99, indicating high performance of the classification method. EEG patterns that interfered with correct classification included vertex sharp transients, sleep spindles, alpha rhythm, and low-amplitude ill-formed spikes in a run. Our results demonstrate that AI is a promising tool for automatically interpreting pediatric EEGs. Some avenues for improving the technique were also indicated by our findings. |
| キーワード | neural network deep learning electroencephalogram children spike |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-12 |
| 巻 | 76巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 617 |
| 終了ページ | 624 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36549763 |
| Web of Science KeyUT | 000905195100001 |
| JaLCDOI | 10.18926/AMO/64025 |
|---|---|
| フルテキストURL | 76_5_503.pdf |
| 著者 | Ogawa, Hirohito| Honda, Tomoyuki| |
| 抄録 | Eukaryotic genomes contain numerous copies of endogenous viral elements (EVEs), most of which are considered endogenous retrovirus (ERV) sequences. Over the past decade, non-retroviral endogenous viral elements (nrEVEs) derived from ancient RNA viruses have been discovered. Several functions have been proposed for these elements, including antiviral defense. This review summarizes the current understanding of nrEVEs derived from RNA viruses, particularly endogenous bornavirus-like elements (EBLs) and endogenous filovirus-like elements (EFLs). EBLs are one of the most extensively studied nrEVEs. The EBL derived from bornavirus nucleoprotein (EBLN) is thought to function as a non-coding RNA or protein that regulates host gene expression or inhibits virus propagation. Ebolavirus and marburgvirus, which are filoviruses, induce severe hemorrhagic fever in humans and nonhuman primates. Although the ecology of filoviruses remains unclear, bats are believed to be potential reservoirs. Based on the knowledge from EBLs, it is postulated that EFLs in the bat genome help to maintain the balance between filovirus infection and the bat’s defense system, which may partially explain why bats act as potential reservoirs. Further research into the functions of nrEVEs could reveal novel antiviral systems and inspire novel antiviral approaches. |
| キーワード | EVE nrEVE bornavirus filovirus antiviral |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-10 |
| 巻 | 76巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 503 |
| 終了ページ | 510 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36352796 |
| Web of Science KeyUT | 000884907100002 |
| JaLCDOI | 10.18926/AMO/64024 |
|---|---|
| フルテキストURL | 76_5_489.pdf |
| 著者 | Matsumoto, Yuji| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Date, Isao| |
| 抄録 | Glioblastoma (GBM) is a fatal primary malignant brain tumor in adults. Despite decades of research, the prognosis for GBM patients is still disappointing. One major reason for the intense therapeutic resistance of GBM is inter- and intra-tumor heterogeneity. GBM-intrinsic transcriptional profiling has suggested the presence of at least three subtypes of GBM: the proneural, classic, and mesenchymal subtypes. The mesenchymal subtype is the most aggressive, and patients with the mesenchymal subtype of primary and recurrent tumors tend to have a worse prognosis compared with patients with the other subtypes. Furthermore, GBM can shift from other subtypes to the mesenchymal subtype over the course of disease progression or recurrence. This phenotypic transition is driven by diverse tumor-intrinsic molecular mechanisms or microenvironmental factors. Thus, better understanding of the plastic nature of mesenchymal transition in GBM is pivotal to developing new therapeutic strategies. In this review, we provide a comprehensive overview of the current understanding of the elements involved in the mesenchymal transition of GBM and discuss future perspectives. |
| キーワード | glioma glioblastoma mesenchymal subtype mesenchymal transition heterogeneity |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-10 |
| 巻 | 76巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 489 |
| 終了ページ | 502 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36352795 |
| Web of Science KeyUT | 000884907100001 |
| JaLCDOI | 10.18926/AMO/63906 |
|---|---|
| フルテキストURL | 76_4_465.pdf |
| 著者 | Bekku, Kensuke| Tsugawa, Takuji| Tsuboi, Kazuma| Noda, Gaku| Inoue, Yousuke| Murao, Wataru| Ebara, Shin| |
| 抄録 | We aimed to identify the role of first-line monotherapy with vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKI) in patients with metastatic RCC. Eligible patients were categorized into three groups (favorable, intermediate, and poor risk) according to the International Metastatic RCC Database Consortium risk criteria. Overall survival (OS) was the primary endpoint. Survival was compared using the log-rank test. A total of 108 patients were retrospectively analyzed. The numbers of patients in the favorable-, intermediate-, and poor-risk groups were 32 (30%), 66 (61%), and 10 (9%), repestively. The median OS values in the entire cohort was 36 months (95% confidence interval [CI] 29-53). The median OS in the favorable, intermediate, and poor risk groups were 94 months (95% CI: 43-Not reached), 30 months (95% CI: 20-38), and 8 months (95% CI: 0-Not reached), respectively (p<0.05). Prior nephrectomy, clear cell histology, clinical T stage ≤2, no metastasis at the time of diagnosis, nivolumab beyond first-line therapy, and objective response to VEGFR-TKIs were factors significantly prolonging OS on univariate analysis. VEGFR-TKI monotherapy as first-line therapy was an effective treatment option for patients with metastatic clear cell RCC with favorable risk. |
| キーワード | metastatic renal cell carcinoma molecular-targeted therapy immuno-checkpoint inhibitor real-world setting |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 465 |
| 終了ページ | 472 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123162 |
| JaLCDOI | 10.18926/AMO/63902 |
|---|---|
| フルテキストURL | 76_4_429.pdf |
| 著者 | Yamadori, Yusuke| Hirao, Tomohiro| Nlandu R. Ngatu| Kanda, Kanae| Syed Mahfuz Al Hasan| Murakami, Akitsu| Mashima, Yukinori| Shirakami, Gotaro| |
| 抄録 | Blood pressure (BP) often rises before surgery. This study investigated whether BP elevation immediately before surgery was associated with adverse outcomes. Medical records of 11,732 patients (average age: 61 years; male: 47.4%) who underwent non-cardiac elective inpatient surgery under general anesthesia at Kagawa University Hospital between January 2011 and June 2019 were reviewed. Differences between the first BP values measured on the day before surgery and the first BP values in the operating room were defined as Δ systolic BP (ΔSBP) and Δ diastolic BP (ΔDBP). The relationships between ΔSBP/ΔDBP and 30-day mortality, 30-day readmission, and over-the-standard length of hospital stay (OSLOS) were assessed. OSLOS was defined as a hospital stay longer than mean+2 standard deviations and was calculated using the Japanese Diagnosis Procedure Combination data. In univariate analysis, the differences in ΔSBP and ΔDBP between the OSLOS and standard LOS groups were both 2 mmHg. In multivariate logistic regression analysis, only ΔDBP was associated with OSLOS. The adjusted odds ratio (95% confidence interval) for the largest quartile was 1.31 (1.02-1.69) (p<0.05). ΔDBP was associated with OSLOS; however, there may be little need to worry about large ΔSBPs and ΔDBPs in clinical practice. |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 429 |
| 終了ページ | 437 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123158 |
| Web of Science KeyUT | 000882167300009 |
| JaLCDOI | 10.18926/AMO/63887 |
|---|---|
| フルテキストURL | 76_4_359.pdf |
| 著者 | Hiramatsu-Asano, Sumie| Wada, Jun| |
| 抄録 | Systemic lupus erythematosus (SLE) is a potentially fatal systemic autoimmune disease, and its etiology involves both genetic and environmental factors such as sex hormone imbalance, genetic predisposition, epigenetic regulation, and immunological factors. Dysregulation of microRNA (miRNA) is suggested to be one of the epigenetic factors in SLE. miRNA is a 22-nucleotide single-stranded noncoding RNA that contributes to post-transcriptional modulation of gene expression. miRNA targeting therapy has been suggested to be useful for the treatment of cancers and other diseases. Gene knockout and miRNA targeting therapy have been demonstrated to improve SLE disease activity in mice. However, these approaches have not yet reached the level of clinical application. miRNA targeting therapy is limited by the fact that each miRNA has multiple targets. In addition, the expression of certain miRNAs may differ among cell tissues within a single SLE patient. This limitation can be overcome by targeted delivery and chemical modifications. In the future, further research into miRNA chemical modifications and delivery systems will help us develop novel therapeutic agents for SLE. |
| キーワード | systemic lupus erythematosus miRNA miRNA targeting therapy |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 359 |
| 終了ページ | 371 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123150 |
| Web of Science KeyUT | 000882167300002 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Oda, Yoshiaki| Takigawa, Tomoyuki| Ito, Yasuo| Misawa, Haruo| Tetsunaga, Tomoko| Uotani, Koji| Ozaki, Toshifumi| |
| キーワード | spine surgery percutaneous pedicle screw percutaneous systems break test fatigue test biomechanical study discipline |
| 発行日 | 2022-04-20 |
| 出版物タイトル | Medicina |
| 巻 | 58巻 |
| 号 | 5号 |
| 出版者 | MDPI |
| 開始ページ | 565 |
| ISSN | 1010-660X |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 35629982 |
| DOI | 10.3390/medicina58050565 |
| Web of Science KeyUT | 000815171700001 |
| 関連URL | isVersionOf https://doi.org/10.3390/medicina58050565 |
| JaLCDOI | 10.18926/AMO/63739 |
|---|---|
| フルテキストURL | 76_3_297.pdf |
| 著者 | Kuroda, Masahiro| Konishi, Kohei| Sugimoto, Kohei| Yoshimura, Yuuki| Hamada, Kentaro| Khasawnehc, Abdullah| Barham, Majd| Tekiki, Nouha| Sugianto, Irfan| Bamgbose, Babatunde O.| Ishizaka, Hinata| Shimizu, Yudai| Nakamitsu, Yuki| Al-Hammad, Wlla E.| Kamizaki, Ryo| Kurozumi, Akira| Matsushita, Toshi| Ohno, Seiichiro| Kanazawa, Susumu| Asaumi, Junichi| |
| 抄録 | Clinical research using restricted diffusion-weighted imaging, especially diffusion kurtosis (DK) imaging, has been progressing, with reports on its effectiveness in the diagnostic imaging of cerebral infarctions, neurodegenerative diseases, and tumors, among others. However, the application of DK imaging in daily clinical practice has not spread because of the long imaging time required and the use of specific software for image creation. Herein, with the aim of promoting clinical research using DK imaging at any medical facility, we evaluated fast DK imaging using a new software program. We developed a new macro program that produces DK images using general-purpose, inexpensive software (Microsoft Excel and ImageJ), and we evaluated fast DK imaging using bio-phantoms and a healthy volunteer in clinical trials. The DK images created by the new software with diffusion-weighted images captured with short-time imaging sequences were similar to the original DK images captured with long-time imaging sequences. The DK images using three b-values, which can reduce the imaging time by 43%, were equivalent to the DK images using five b-values. The DK imaging technique developed herein might allow any medical facility to increase its daily clinical use of DK imaging and easily conduct clinical research. |
| キーワード | fast diffusion kurtosis imaging mean kurtosis restricted diffusion Excel ImageJ |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-06 |
| 巻 | 76巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 297 |
| 終了ページ | 305 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35790360 |
| Web of Science KeyUT | 000823568300009 |
| フルテキストURL | fulltext20220623-4.pdf |
|---|---|
| 著者 | 中尾 知代| |
| 備考 | 著作権者の許諾を得て出版社版を掲載|
(上)第22号(98年冬季)pp.27-35 (中)第23号(99年春季)pp.27-39 (下)第26号(99年冬季)pp.77-84| |
| 発行日 | 1999 |
| 出版物タイトル | 季刊戦争責任研究 |
| 号 | 26号 |
| 出版者 | 日本の戦争責任資料センター |
| 開始ページ | 77 |
| 終了ページ | 84 |
| ISSN | 13437348 |
| NCID | AN10431480 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | publisher |
| フルテキストURL | fulltext20220623-3.pdf |
|---|---|
| 著者 | 中尾 知代| |
| 備考 | 著作権者の許諾を得て出版社版を掲載|
(上)第22号(98年冬季)pp.27-35 (中)第23号(99年春季)pp.27-39 (下)第26号(99年冬季)pp.77-84| |
| 発行日 | 1999 |
| 出版物タイトル | 季刊戦争責任研究 |
| 号 | 23号 |
| 出版者 | 日本の戦争責任資料センター |
| 開始ページ | 27 |
| 終了ページ | 39 |
| ISSN | 13437348 |
| NCID | AN10431480 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 日本語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | publisher |
| フルテキストURL | fulltext20220623-2.pdf |
|---|---|
| 著者 | 中尾 知代| |
| 備考 | 著作権者の許諾を得て出版社版を掲載|
(上)第22号(98年冬季)pp.27-35 (中)第23号(99年春季)pp.27-39 (下)第26号(99年冬季)pp.77-84| |
| 発行日 | 1998 |
| 出版物タイトル | 季刊戦争責任研究 |
| 号 | 22号 |
| 出版者 | 日本の戦争責任資料センター |
| ISSN | 13437348 |
| NCID | AN10431480 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | publisher |
| JaLCDOI | 10.18926/AMO/63218 |
|---|---|
| フルテキストURL | 76_1_93.pdf |
| 著者 | Ishi, Yukitomo| Yamaguchi, Shigeru| Hatanaka, Kanako C.| Takakuwa, Emi| Motegi, Hiroaki| Honda, Taishi| Kobayashi, Hiroyuki| Terasaka, Shunsuke| Homma, Akihiro| Fujimura, Miki| Houkin, Kiyohiro| |
| 抄録 | A 66-year-old man underwent multimodal treatment for olfactory neuroblastoma (ONB). When he was 72 years old, a cystic intracranial lesion without accumulation on fluorine-18-fluorodeoxyglucose positron emission tomography was detected. Surgical resection was performed when the patient was 73 years old. The pathological examination revealed recurrence of ONB, and the patient underwent focal irradiation. At age 81, he presented with a second recurrence in the right occipital lobe with radiological and pathological findings similar to the prior recurrence. This case suggests that pathological confirmation should be considered in cases with atypical radiological findings following the treatment of ONB. |
| キーワード | cystic recurrence esthesioneuroblastoma fluorine-18-fluorodeoxyglucose positron emission tomography intracranial recurrence olfactory neuroblastoma |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-02 |
| 巻 | 76巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 93 |
| 終了ページ | 98 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 35237005 |
| Web of Science KeyUT | 000762933000002 |