検索結果 728 件
フルテキストURL | fulltext.pdf |
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著者 | Takase, Y.| Vacher, L.| Ishino, H.| Patanchon, G.| Montier, L.| Stever, S.L.| Ishizaka, K.| Nagano, Y.| Wang, W.| Aumont, J.| Aizawa, K.| Anand, A.| Baccigalupi, C.| Ballardini, M.| Banday, A.J.| Barreiro, R.B.| Bartolo, N.| Basak, S.| Bersanelli, M.| Bortolami, M.| Brinckmann, T.| Calabrese, E.| Campeti, P.| Carinos, E.| Carones, A.| Casas, F.J.| Cheung, K.| Clermont, L.| Columbro, F.| Coppolecchia, A.| Cuttaia, F.| D'Alessandro, G.| de Bernardis, P.| de Haan, T.| de la Hoz, E.| Della Torre, S.| Diego-Palazuelos, P.| Eriksen, H.K.| Errard, J.| Finelli, F.| Fuskeland, U.| Galloni, G.| Galloway, M.| Gervasi, M.| Ghigna, T.| Giardiello, S.| Gimeno-Amo, C.| Gjerløw, E.| González González, R.| Gruppuso, A.| Hazumi, M.| Henrot-Versillé, S.| Hergt, L.T.| Ikuma, K.| Kohri, K.| Lamagna, L.| Lattanzi, M.| Leloup, C.| Lembo, M.| Levrier, F.| Lonappan, A.I.| López-Caniego, M.| Luzzi, G.| Maffei, B.| Martínez-González, E.| Masi, S.| Matarrese, S.| Matsuda, F.T.| Matsumura, T.| Micheli, S.| Migliaccio, M.| Monelli, M.| Morgante, G.| Mot, B.| Nagata, R.| Namikawa, T.| Novelli, A.| Odagiri, K.| Oguri, S.| Omae, R.| Pagano, L.| Paoletti, D.| Piacentini, F.| Pinchera, M.| Polenta, G.| Porcelli, L.| Raffuzzi, N.| Remazeilles, M.| Ritacco, A.| Ruiz-Granda, M.| Sakurai, Y.| Scott, D.| Sekimoto, Y.| Shiraishi, M.| Signorelli, G.| Sullivan, R.M.| Takakura, H.| Terenzi, L.| Tomasi, M.| Tristram, M.| van Tent, B.| Vielva, P.| Wehus, I.K.| Westbrook, B.| Weymann-Despres, G.| Wollack, E.J.| Zannoni, M.| Zhou, Y.| |
キーワード | CMBR experiments CMBR polarisation gravitational waves and CMBR polarization |
発行日 | 2024-12 |
出版物タイトル | Journal of Cosmology and Astroparticle Physics |
巻 | 2024巻 |
号 | 12号 |
出版者 | IOP Publishing |
ISSN | 1475-7516 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2024 The Author(s) |
論文のバージョン | publisher |
DOI | 10.1088/1475-7516/2024/12/036 |
Web of Science KeyUT | 001379854100009 |
関連URL | isVersionOf https://doi.org/10.1088/1475-7516/2024/12/036 |
著者 | Zou, Yajuan| Ohkura, Kentaro| Ortiz‐Anaya, Israel| Kimura, Ryota| Bianco, Alberto| Nishina, Yuta| |
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キーワード | Carbon nanomaterials Epoxide ring-opening Catalysis Polyglycerol functionalization |
備考 | This is the peer reviewed version of the following article: [Y. Zou, K. Ohkura, I. Ortiz-Anaya, R. Kimura, A. Bianco, Y. Nishina, Chem. Eur. J. 2025, e202404400. https://doi.org/10.1002/chem.202404400], which has been published in final form at [https://doi.org/10.1002/chem.202404400]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext file will be available in Jan. 2026.| |
発行日 | 2025-01-07 |
出版物タイトル | Chemistry – A European Journal |
出版者 | Wiley |
開始ページ | e202404400 |
ISSN | 0947-6539 |
NCID | AA11076269 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2024 Wiley-VCH GmbH |
論文のバージョン | publisher |
PubMed ID | 39714895 |
DOI | 10.1002/chem.202404400 |
Web of Science KeyUT | 001390977300001 |
関連URL | isVersionOf https://doi.org/10.1002/chem.202404400 |
著者 | Tokushige, Keisuke| Asai, Shota| Abe, Takumi| |
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キーワード | 2-vinylanilines indolines Potassium tert-butoxide Elimination Ring-opening |
備考 | This is the peer reviewed version of the following article: [K. Tokushige, S. Asai, T. Abe, Asian J. Org. Chem. 2024, e202400552. https://doi.org/10.1002/ajoc.202400552], which has been published in final form at [https://doi.org/10.1002/ajoc.202400552]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext file will be available in Dec. 2025.| |
発行日 | 2024-12-17 |
出版物タイトル | Asian Journal of Organic Chemistry |
出版者 | Wiley |
ISSN | 2193-5807 |
NCID | AA12586329 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2024 Wiley-VCH GmbH |
論文のバージョン | author |
DOI | 10.1002/ajoc.202400552 |
Web of Science KeyUT | 001378736900001 |
関連URL | isVersionOf https://doi.org/10.1002/ajoc.202400552 |
フルテキストURL | fulltext.pdf |
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著者 | Morita, Satoru| Tokumasu, Kazuki| Otsuka, Yuki| Honda, Hiroyuki| Nakano, Yasuhiro| Sunada, Naruhiko| Sakurada, Yasue| Matsuda, Yui| Soejima, Yoshiaki| Ueda, Keigo| Otsuka, Fumio| |
発行日 | 2024-12-09 |
出版物タイトル | PLoS ONE |
巻 | 19巻 |
号 | 12号 |
出版者 | Public Library of Science |
開始ページ | e0315385 |
ISSN | 1932-6203 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2024 Morita et al. |
論文のバージョン | publisher |
PubMed ID | 39652555 |
DOI | 10.1371/journal.pone.0315385 |
Web of Science KeyUT | 001373564500009 |
関連URL | isVersionOf https://doi.org/10.1371/journal.pone.0315385 |
フルテキストURL | fulltext.pdf |
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著者 | Taoka, Masataka| Ichihara, Eiki| Yokoyama, Toshihide| Inoue, Koji| Tamura, Tomoki| Sato, Akiko| Oda, Naohiro| Kano, Hirohisa| Nakamura, Kayo| Kawai, Haruyuki| Inoue, Masaaki| Ochi, Nobuaki| Fujimoto, Nobukazu| Ichikawa, Hirohisa| Ando, Chihiro| Oze, Isao| Kiura, Katsuyuki| Maeda, Yoshinobu| Hotta, Katsuyuki| |
キーワード | non-small cell lung cancer body weight loss immune checkpoint inhibitors chemotherapy |
発行日 | 2024-12-06 |
出版物タイトル | Cancers |
巻 | 16巻 |
号 | 23号 |
出版者 | MDPI |
開始ページ | 4089 |
ISSN | 2072-6694 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2024 by the authors. |
論文のバージョン | publisher |
PubMed ID | 39682275 |
DOI | 10.3390/cancers16234089 |
Web of Science KeyUT | 001376843000001 |
関連URL | isVersionOf https://doi.org/10.3390/cancers16234089 |
フルテキストURL | fulltext.pdf |
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著者 | Shimanouchi, Toshinori| Hirota, Daichi| Yoshida, Masafumi| Yasuhara, Kazuma| Kimura, Yukitaka| |
キーワード | polymer particles emulsification water repellency hydrophobicity coating convective self-assembly wood thin board |
発行日 | 2024-12-04 |
出版物タイトル | Applied Sciences |
巻 | 14巻 |
号 | 23号 |
出版者 | MDPI |
開始ページ | 11326 |
ISSN | 2076-3417 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2024 by the authors. |
論文のバージョン | publisher |
DOI | 10.3390/app142311326 |
Web of Science KeyUT | 001376202300001 |
関連URL | isVersionOf https://doi.org/10.3390/app142311326 |
JaLCDOI | 10.18926/AMO/67878 |
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フルテキストURL | 78_6_475.pdf |
著者 | Xiang, Hongfei| Latka, Kajetan| Maste, Praful| Tanaka, Masato| Kumawat, Chetan| Arataki, Shinya| Fujiwara, Yoshihiro| Taoka, Takuya| Miyamoto, Akiyoshi| |
抄録 | This report presents a new unilateral biportal endoscopic (UBE) technique for lumbar disc herniation without C-arm guidance. Lumbar disc herniation requires surgical intervention when conservative methods fail. Shifts towards minimally invasive percutaneous endoscopic lumbar discectomy, including uniportal and biportal approaches, have been hindered by challenges such as steep learning curves and reliance on radiation-intensive C-arm guidance. We here describe the use of standard intraoperative navigation in UBE to reduce radiation exposure and increase surgical accuracy. A 24-year-old man with low back and bilateral leg pain with gait disturbance was referred to our hospital. He had had conservative treatment for 12 months in another hospital before admission, but this proved unsuccessful. On admission he had low back pain (VAS 4/10) and bilateral leg pain (VAS 8/10), muscle weakness of the bilateral legs (manual muscle testing (MMT) grade of the extensor hallucis longus: 4/4), and numbness of the bilateral lower legs. Preoperative lumbar MRI showed L4/5 large central disc herniation. He underwent C-arm free UBE discectomy under the guidance of O-arm navigation. The surgery was successful, with postoperative lumbar MRI showing good decompression of the dural sac and bilateral L5 nerve roots. The MMT grade and sensory function of both legs had recovered fully on final follow-up at one year. The new UBE technique under navigation guidance was shown to be useful for lumbar disc herniation. This innovative technique was safe and accurate for the treatment of lumbar intervertebral disc herniation, and minimized radiation exposure to surgeons. |
キーワード | lumbar disc herniation unilateral biportal endoscopic technique navigation O-arm minimally invasive spine surgery (MISS) |
Amo Type | Case Report |
出版物タイトル | Acta Medica Okayama |
発行日 | 2024-12 |
巻 | 78巻 |
号 | 6号 |
出版者 | Okayama University Medical School |
開始ページ | 475 |
終了ページ | 483 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 39719322 |
Web of Science KeyUT | 001397269500004 |
フルテキストURL | fulltext.pdf |
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著者 | Nakamura, Keiichiro| Shigeyasu, Kunitoshi| Vu, Thuy Ha| Maki, Jota| Okamoto, Kazuhiro| Masuyama, Hisashi| |
キーワード | ADAR1 Chorioamnionitis Funisitis Intrauterine infection Diagnostic biomarker |
備考 | The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-024-81097-4| |
発行日 | 2024-11-27 |
出版物タイトル | Scientific Reports |
巻 | 14巻 |
号 | 1号 |
出版者 | Nature Portfolio |
開始ページ | 29419 |
ISSN | 2045-2322 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s) 2024 |
論文のバージョン | publisher |
PubMed ID | 39592688 |
DOI | 10.1038/s41598-024-81097-4 |
Web of Science KeyUT | 001364770700004 |
関連URL | isVersionOf https://doi.org/10.1038/s41598-024-81097-4 |
JaLCDOI | 10.18926/AMO/67869 |
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フルテキストURL | 78_6_439.pdf |
著者 | Yamashita, Mampei| Tanaka, Takayuki| Sumida, Yorihisa| Yamazaki, Shoto| Hara, Yuki| Fukuda, Akiko| Hisanaga, Makoto| Wakata, Koki| Araki, Masato| Eguchi, Susumu| |
抄録 | Gangrenous cholecystitis (GC) is classified as moderate acute cholecystitis according to the Tokyo Guidelines from 2018 (TG18). We evaluated the risk factors for GC and the outcomes of early cholecystectomy. A total of 136 patients who underwent emergency cholecystectomy for acute cholecystitis were retrospectively analyzed; 58 of these patients (42.6%) were diagnosed with GC (GC group) based on our retrospective pathologic diagnosis. We comparatively evaluated the patient backgrounds and surgical outcomes between the GC group and non-GC group. The GC group was significantly older and included more hypertensive patients than the non-GC group. The GC group was prescribed more antibiotics as initial treatment than the non-GC group, and they had more days between onset and surgery. The preoperative white blood cell count and C-reactive protein values were significantly higher in the GC group than in the non-GC group, and these values were predictive factors for GC. Cholecystectomy required a longer operation time and caused greater blood loss in the GC group. The GC group also had longer hospitalization times than the non-GC group; however, no significant differences were observed in terms of postoperative complications. In conclusion, gangrenous changes should be assessed when diagnosing cholecystitis, and appropriate treatment, such as surgery or drainage, should be undertaken. |
キーワード | gangrenous cholecystitis acute cholecystitis laparoscopic cholecystectomy |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2024-12 |
巻 | 78巻 |
号 | 6号 |
出版者 | Okayama University Medical School |
開始ページ | 439 |
終了ページ | 447 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 39719316 |
Web of Science KeyUT | 001397799300002 |
JaLCDOI | 10.18926/AMO/67868 |
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フルテキストURL | 78_6_429.pdf |
著者 | Kubota, Risa| Bekku, Kensuke| Katayama, Satoshi| Iwata, Takehiro| Nishimura, Shingo| Edamura, Kohei| Kobayashi, Tomoko| Kobayashi, Yasuyuki| Araki, Motoo| |
抄録 | Although partial nephrectomy (PN) is preferred over radical nephrectomy (RN) for preserving renal function in patients with cT1 renal cancer, its impact on cardiovascular events (CVe) remains controversial. This study aimed to compare PN and RN in regard to the occurrence of CVe, including cerebrovascular events and exacerbation of hypertension (HT). We retrospectively analyzed 418 consecutive patients who underwent PN or RN for cT1 renal cancer. Propensity score-matching analysis was used to adjust for imbalances between patients who underwent PN and RN, leaving 102 patients in each group. The 5-year probability of cumulative CVe incidence was 6% in the PN group and 12% in the RN group (p=0.03), with a median follow-up of 73.5 months. The statistical significance was retained after propensity score matching for patients without preoperative proteinuria (p=0.03). For all CVe including cerebrovascular events and exacerbation of HT analyzed, PN provided a lower probability of occurrence than RN in patients with small renal cancers. |
キーワード | chronic kidney disease hypertension nephrectomy proteinuria |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2024-12 |
巻 | 78巻 |
号 | 6号 |
出版者 | Okayama University Medical School |
開始ページ | 429 |
終了ページ | 437 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 39719315 |
Web of Science KeyUT | 001397799300001 |
フルテキストURL | K0007109_abstract_review.pdf K0007109_summary.pdf K0007109_fulltext.pdf K0007109_other_Figure.pdf K0007109_other_TableS1.pdf K0007109_other_TableS2.pdf K0007109_other_TableS3.pdf K0007109_other_TableS4.pdf |
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著者 | 爲房 宏輔| |
発行日 | 2024-09-25 |
資料タイプ | 学位論文 |
学位授与番号 | 甲第7109号 |
学位授与年月日 | 2024-09-25 |
学位・専攻分野 | 博士(医学) |
授与大学 | 岡山大学 |
言語 | 英語 |
著作権者 | © 2023 John Wiley & Sons A/S. |
フルテキストURL | K0007088_abstract_review.pdf K0007088_fulltext.pdf K0007088_other.pdf K0007088_summary.pdf |
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著者 | 宮原 大輔| |
発行日 | 2024-09-25 |
資料タイプ | 学位論文 |
学位授与番号 | 甲第7088号 |
学位授与年月日 | 2024-09-25 |
学位・専攻分野 | 博士(医学) |
授与大学 | 岡山大学 |
言語 | 英語 |
著作権者 | © 2023 Wiley Periodicals LLC. |
フルテキストURL | fulltext.pdf |
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著者 | Umebayashi, Ryoko| Matsuoka-Uchiyama, Natsumi| Sugiyama, Hitoshi| Shikata, Kenichi| Kashihara, Naoki| Makino, Hirofumi| Wada, Jun| Uchida, Haruhito A.| |
キーワード | chronic kidney disease CKD perceptance CKD public education programs |
発行日 | 2024-10-25 |
出版物タイトル | Diseases |
巻 | 12巻 |
号 | 11号 |
出版者 | MDPI |
開始ページ | 268 |
ISSN | 2079-9721 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2024 by the authors. |
論文のバージョン | publisher |
DOI | 10.3390/diseases12110268 |
Web of Science KeyUT | 001364842200001 |
関連URL | isVersionOf https://doi.org/10.3390/diseases12110268 |
フルテキストURL | fulltext.pdf |
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著者 | Hashimoto, Chiaki| Yorifuji, Takashi| Murakami, Kazuharu| Suganami, Shigeru| |
キーワード | Common disease communicable disease control disaster flood heavy rains Okayama |
発行日 | 2023-04-14 |
出版物タイトル | JMA Journal |
巻 | 6巻 |
号 | 2号 |
出版者 | Japan Medical Association |
開始ページ | 129 |
終了ページ | 137 |
ISSN | 2433-3298 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © Japan Medical Association |
論文のバージョン | publisher |
PubMed ID | 37179731 |
DOI | 10.31662/jmaj.2022-0122 |
Web of Science KeyUT | 001149290800004 |
関連URL | isVersionOf https://doi.org/10.31662/jmaj.2022-0122 |
フルテキストURL | fulltext.pdf |
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著者 | Furumatsu, Takayuki| Kintaka, Keisuke| Higashihara, Naohiro| Tamura, Masanori| Kawada, Koki| Xue, Haowei| Ozaki, Toshifumi| |
キーワード | Medial meniscus Posterior root Partial tear Meniscal extrusion Operative indication |
備考 | The version of record of this article, first published in Knee Surgery & Related Research, is available online at Publisher’s website: http://dx.doi.org/10.1186/s43019-023-00182-6| |
発行日 | 2023-03-14 |
出版物タイトル | Knee Surgery & Related Research |
巻 | 35巻 |
号 | 1号 |
出版者 | Springer Science and Business Media LLC |
開始ページ | 8 |
ISSN | 2234-2451 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s) 2023. |
論文のバージョン | publisher |
PubMed ID | 36918982 |
DOI | 10.1186/s43019-023-00182-6 |
Web of Science KeyUT | 000949319200001 |
関連URL | isVersionOf https://doi.org/10.1186/s43019-023-00182-6 |
フルテキストURL | fulltext.pdf |
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著者 | Fuji, Tomokazu| Umeda, Yuzo| Takagi, Kosei| Hioki, Masayoshi| Yoshida, Ryuichi| Endo, Yoshikatsu| Yasui, Kazuya| Nobuoka, Daisuke| Mitsuhashi, Toshiharu| Fujiwara, Toshiyoshi| |
キーワード | Education High-volume hospital Learning curve Pancreaticoduodenectomy |
備考 | The version of record of this article, first published in BMC Surgery, is available online at Publisher’s website: http://dx.doi.org/10.1186/s12893-024-02677-9| |
発行日 | 2024-11-20 |
出版物タイトル | BMC Surgery |
巻 | 24巻 |
号 | 1号 |
出版者 | BMC |
開始ページ | 366 |
ISSN | 1471-2482 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s) 2024. |
論文のバージョン | publisher |
PubMed ID | 39563307 |
DOI | 10.1186/s12893-024-02677-9 |
Web of Science KeyUT | 001360181700004 |
関連URL | isVersionOf https://doi.org/10.1186/s12893-024-02677-9 |
フルテキストURL | fulltext.pdf |
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著者 | Vu, Thuy Ha| Nakamura, Keiichiro| Shigeyasu, Kunitoshi| Kashino, Chiaki| Okamoto, Kazuhiro| Kubo, Kotaro| Kamada, Yasuhiko| Masuyama, Hisashi| |
キーワード | Apolipoprotein-B mRNA-editing complex 3B Endometriosis Apoptosis Potential therapeutic target |
備考 | The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-024-76589-2| |
発行日 | 2024-10-23 |
出版物タイトル | Scientific Reports |
巻 | 14巻 |
号 | 1号 |
出版者 | Nature Portfolio |
開始ページ | 24968 |
ISSN | 2045-2322 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © The Author(s) 2024 |
論文のバージョン | publisher |
PubMed ID | 39443671 |
DOI | 10.1038/s41598-024-76589-2 |
Web of Science KeyUT | 001341352800136 |
関連URL | isVersionOf https://doi.org/10.1038/s41598-024-76589-2 |
フルテキストURL | fulltext.pdf |
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著者 | Hou, Yafei| Yano, Kazuto| Suga, Norisato| Webber, Julian| Denno, Satoshi| Sakano, Toshikazu| |
キーワード | Interference detection MUSIC spectrum interference localization prediction of interference arrival probabilistic neural network |
発行日 | 2024-10-01 |
出版物タイトル | IEEE Access |
巻 | 12巻 |
出版者 | Institute of Electrical and Electronics Engineers |
開始ページ | 142592 |
終了ページ | 142605 |
ISSN | 2169-3536 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
OAI-PMH Set | 岡山大学 |
著作権者 | © 2024 The Authors. |
論文のバージョン | publisher |
DOI | 10.1109/ACCESS.2024.3470894 |
Web of Science KeyUT | 001338145500001 |
関連URL | isVersionOf https://doi.org/10.1109/ACCESS.2024.3470894 |
JaLCDOI | 10.18926/AMO/67665 |
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フルテキストURL | 78_5_407.pdf |
著者 | Shimoyama, Kyoko| Nakajima, Atsushi| Minari, Yoshimitsu| |
抄録 | Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, but they have been known to cause immune-related adverse events (irAEs) by promoting T-cell activation. Neurological irAEs are rare (1%) but have a high fatality rate (11.5%). Here we report the first case of Bickerstaff brainstem encephalitis (BBE) induced by an ICI. A woman in her 60s with metastatic breast cancer was treated with atezolizumab plus nab-paclitaxel once intravenously. Eighteen days later, she lost consciousness with ophthalmoplegia and was diagnosed with a neurological irAE. She recovered consciousness immediately with the administration of intravenous immunoglobulin (IVIG) but suffered severe permanent peripheral neuropathy. Although it is just one case, this experience shows that BBE occurring as a neurological irAE of ICI cancer treatment may be associated with more severe outcomes than conventional BBE in metastatic cancer. Creating a system for multidisciplinary treatment is essential for ICI therapy. |
キーワード | Bickerstaff brainstem encephalitis immune checkpoint inhibitor atezolizumab neurological immune-related adverse event breast cancer |
Amo Type | Case Report |
出版物タイトル | Acta Medica Okayama |
発行日 | 2024-10 |
巻 | 78巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 407 |
終了ページ | 412 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 39467659 |
Web of Science KeyUT | 001343346400007 |
JaLCDOI | 10.18926/AMO/67662 |
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フルテキストURL | 78_5_377.pdf |
著者 | Hirano, Yuichi| Nouso, Kazuhiro| Kariyama, Kazuya| Hiraoka, Atsushi| Shiota, Shohei| Wakuta, Akiko| Yasuda, Satoshi| Toyoda, Hidenori| Tsuji, Kunihiko| Hatanaka, Takeshi| Kakizaki, Satoru| Naganuma, Atsushi| Tada, Toshifumi| Itobayashi, Ei| Ishikawa, Toru| Shimada, Noritomo| Takaguchi, Koichi| Tsutsui, Akemi| Nagano, Takuya| Imai, Michitaka| Nakamura, Shinichiro| Kumada, Takashi| Real-Life Practice Experts for HCC (RELPEC) Study Group in Japan| |
抄録 | We previously found that “albumin grade”, formerly called the “ALBS grade,” demonstrated significant capability for prognostic stratification in hepatocellular carcinoma (HCC) patients treated with lenvatinib. The purpose of the present study was to compare the performance of the albumin grade with that of the modified albumin-bilirubin (mALBI) grade in predicting overall survival of HCC patients with different BCLC stages and treatment types. We enrolled 7,645 Japanese patients newly diagnosed with HCC using the Akaike information criteria (AIC), likelihood ratio, and C-index in different Barcelona Clinic Liver Cancer (BCLC) stages and treatments. The albumin grade showed similar and slightly better performance than the mALBI grade for BCLC stage 0 and A and especially for patients who underwent curative surgery and ablation. In patients treated with transcatheter arterial chemoembolization, molecular targeted agents, and the best supportive care, the mALBI grade had better performance than the albumin grade. However, the differences of the indices were very small in all scenarios. Overall, the albumin grade was comparable in efficacy to the mALBI grade, showing particular benefit for patients with early-stage HCC. |
キーワード | albumin grade hepatocellular carcinoma modified albumin-bilirubin grade |
Amo Type | Original Article |
出版物タイトル | Acta Medica Okayama |
発行日 | 2024-10 |
巻 | 78巻 |
号 | 5号 |
出版者 | Okayama University Medical School |
開始ページ | 377 |
終了ページ | 386 |
ISSN | 0386-300X |
NCID | AA00508441 |
資料タイプ | 学術雑誌論文 |
言語 | 英語 |
著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
論文のバージョン | publisher |
査読 | 有り |
PubMed ID | 39467656 |
Web of Science KeyUT | 001343346400004 |