検索結果 - 岡山大学学術成果リポジトリ

Relationship between Intracellular Signaling of the (Pro)renin Receptor and the Pathogenesis of Preeclampsia

JaLCDOI	10.18926/AMO/57374
フルテキストURL	73_5_433.pdf
著者	Tamada, Shoko\| Mitsui, Takashi\| Ohira, Akiko\| Tani, Kazumasa\| Maki, Jota\| Eguchi, Takeshi\| Eto, Eriko\| Hayata, Kei\| Masuyama, Hisashi\|
抄録	An association between preeclampsia and (pro)renin was recently reported. Intracellular signaling of the (pro) renin receptor [(P)RR] increases the expressions of TGF-β and PAI-1. In this study we sought to clarify the involvement of (pro)renin in the pathogenesis of preeclampsia via the intracellular signaling of (P)RR on preeclampsia placentas. Activated (pro)renin plasma concentrations were compared between pregnant women with (n=15) and without (n=28) preeclampsia. The placentas were immunohistochemically evaluated with anti-HIF-1α and anti-(P)RR antibodies. HTR-8/SVneo cells were cultured under hypoxic conditions and treated with human recombinant (pro)renin. The mRNA expressions of HIF-1α, (P)RR, PAI-1, TGF-β, and ET-1 were also examined by real-time RCR. The activated (pro)renin plasma concentration was significantly higher in the third vs. the second trimester in the preeclampsia patients. HIF-1α and (P)RR expressions were significantly increased in the preeclampsia placentas. The mRNA expressions of PAI-1, TGF-β, and ET-1 were significantly increased in the experiments using recombinant (pro)renin vs. hypoxic conditions. (P)RR expression in preeclampsia placentas is increased by persistent hypoxia through the second and third trimesters, and PAI-1, TGF-β, and ET-1 production is increased via (P)RR. Our results suggest that ET-1 production via the intracellular signaling of (P)RR is important in the pathogenesis of preeclampsia.
キーワード	preeclampsia (pro)renin (pro)renin receptor endothelin-1 HTR-8/SVneo
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2019-10
巻	73巻
号	5号
出版者	Okayama University Medical School
開始ページ	433
終了ページ	440
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31649370
Web of Science KeyUT	000491886600009

“Active Guide” Brochure Reduces Sedentary Behavior of Elderly People: A Randomized Controlled Trial

JaLCDOI	10.18926/AMO/57373
フルテキストURL	73_5_427.pdf
著者	Owari, Yutaka\| Suzuki, Hiromi\| Miyatake, Nobuyuki\|
抄録	The aim of this study was to examine in a randomized controlled trial how much the sedentary behavior (sitting time) of community-dwelling elderly Japanese subjects decreased as a result of using the “Active Guide” brochure published by the Ministry of Health, Labour and Welfare (2013) and additional documents related to the benefits of reducing sedentary behavior. A total of 86 elderly people who participated in health-club activities for one year were randomly allocated to two groups. Subjects in the intervention group received explanations of the importance of physical activity using the “Active Guide” brochure (n=42) and additional documents, while subjects in the control group did not (n=44). Physical activity was measured using a triaxial accelerometer for two weeks at baseline and again after one year. After one year of intervention, the difference in the sedentary behavior rate from baseline was −2.2% for the intervention group (n=40) and +2.5% for controls (n=40) (Welch’s t-test, p=0.007). Use of the “Active Guide” brochure and additional documents may reduce the sedentary behavior of community dwelling elderly people in Japan.
キーワード	Active Guide sedentary behavior elderly people randomized controlled trial health promotion
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2019-10
巻	73巻
号	5号
出版者	Okayama University Medical School
開始ページ	427
終了ページ	432
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31649369
Web of Science KeyUT	000491886600008

Relationship between Sedentary Behavior and All-cause Mortality in Japanese Chronic Hemodialysis Patients: A Prospective Cohort Study

JaLCDOI	10.18926/AMO/57372
フルテキストURL	73_5_419.pdf
著者	Hishii, Shuhei\| Miyatake, Nobuyuki\| Nishi, Hiroyuki\| Katayama, Akihiko\| Ujike, Kazuhiro\| Koumoto, Kiichi\| Suzuki, Hiromi\| Hashimoto, Hiroo\|
抄録	We investigated the relationship between sedentary behavior and all-cause mortality in patients undergoing hemodialysis. A total of 71 patients (39 men, 32 women, aged 72.1±11.7 years) were enrolled in this longitudinal study. Their sedentary behavior was measured using a tri-accelerometer that provides relative values per daily wearing time. We classified the sedentary behavior time into 2 groups (under the median: short-sedentary behavior (SB) group; over the median: long-SB group) and compared the groups’ clinical parameters. We compared the groups’ survival rates by using Kaplan-Meier curves and the log-rank test, and we performed multivariate analyses by a Cox-proportional hazard model to evaluate the relationship between the sedentary behavior and the survival rate. Twenty patients (28.2%) died during the observation period. The survival rate of the short-SB group was significantly higher than that of the long-SB group. Sedentary behavior was thus an important factor for all-cause mortality even after adjusting for confounding factors by a Cox-proportional hazard model. Sedentary behavior is closely linked to all-cause mortality, especially total days and non-hemodialysis days, and reducing sedentary behavior may be beneficial to reduce the all-cause mortality of patients on chronic hemodialysis.
キーワード	sedentary behavior hemodialysis mortality physical activity
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2019-10
巻	73巻
号	5号
出版者	Okayama University Medical School
開始ページ	419
終了ページ	425
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31649368
Web of Science KeyUT	000491886600007

Risk Factors for Low Bone Mineral Density Determined in Patients in a General Practice Setting

JaLCDOI	10.18926/AMO/57370
フルテキストURL	73_5_403.pdf
著者	Ando, Akemi\| Mitsuhashi, Toshiharu\| Honda, Mitsugi\| Hanayama, Yoshihisa\| Hasegawa, Kou\| Obika, Mikako\| Kataoka, Hitomi\| Otsuka, Fumio\|
抄録	Osteoporosis increases the risk of bone fractures. It is diagnosed based on an individual’s bone mineral density (BMD) or a fracture without trauma. BMD is usually measured by the dual energy X-ray absorptiometry (DXA) method. Here we investigated factors for the earliest possible prediction of decreased BMD by examining the relationships between patients’ BMD values and changes in the patients’ physical and laboratory values. We retrospectively reviewed the medical records of 149 patients who visited our department in 2014-2015 for a variety of reasons and underwent an area BMD examination by DXA. We analyzed the relationships between decreasing BMD and the patients’ gender, age, body mass index (BMI), medical background, hemoglobin, electrolytes, and thyroid function. Thirty-nine of the patients were diagnosed with osteoporosis based on their T-scores. An adjusted analysis showed that female gender, aging, and increased serum calcium level were significantly related to decreasing femoral BMD, whereas high BMI was associated with an increase in femoral BMD. Collectively the results indicate that for the early detection of low BMD, it is important for general-practice physicians to consider conducting a BMD checkup when treating female and elderly patients with a low BMI and/or elevated serum calcium level.
キーワード	bone mineral density (BMD) body mass index (BMI) female gender hypercalcemia osteoporosis
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2019-10
巻	73巻
号	5号
出版者	Okayama University Medical School
開始ページ	403
終了ページ	411
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31649366
Web of Science KeyUT	000491886600005

Effects of temperature during successive generations on life-history traits in a seed beetle Callosobruchus chinensis (Chrysomelidae: Coleoptera)

フルテキストURL	ApplEntomolZool_2019_00643.pdf
著者	Terada, Kenji\| Matsumura, Kentarou\| Miyatake, Takahisa\|
キーワード	Temperature Experimental evolution Hatching rate Seed beetle Callosobruchus chinensis
備考	This is an Accepted Manuscript of an article published by Springer Japan\|
発行日	2019-09-13
出版物タイトル	Applied Entomology and Zoology
巻	54巻
出版者	Springer Japan
開始ページ	459
終了ページ	464
ISSN	00036862
NCID	AA00543238
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
DOI	10.1007/s13355-019-00643-z
NAID	40022061862
Web of Science KeyUT	000503219100014
関連URL	isVersionOf https://doi.org/10.1007/s13355-019-00643-z

Transcriptomic comparison between beetle strains selected for short and long durations of death feigning

フルテキストURL	SciRep_9_1_14001_p.pdf
著者	Uchiyama, Hironobu\| Sasaki, Ken\| Hinosawa, Shogo\| Tanaka, Keisuke\| Matsumura, Kentarou\| Yajima, Shunsuke\| Miyatake, Takahisa\|
発行日	2019-09-30
出版物タイトル	Scientific reports
巻	9巻
号	1号
出版者	Springer Nature
開始ページ	14001
ISSN	20452322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2019
論文のバージョン	publisher
PubMed ID	31570743
DOI	10.1038/s41598-019-50440-5
Web of Science KeyUT	000488223900004
関連URL	isVersionOf https://doi.org/10.1038/s41598-019-50440-5

Behavioural effects of inhalation exposure to dizocilpine (MK-801) in mice

フルテキストURL	Biomed_Pharmacother_2019109038.pdf
著者	Ueno, Hiroshi\| Suemitsu, Shunsuke\| Murakami, Shinji\| Kitamura, Naoya\| Wani, Kenta\| Takahashi, Yu\| Matsumoto, Yosuke\| Okamoto, Motoi\| Ishihara, Takeshi\|
キーワード	Inhalation Dizocilpine MK-801 Mouse Drug Schizophrenia
発行日	2019-09-30
出版物タイトル	Biomedicine & Pharmacotherapy
巻	117巻
出版者	Elsevier
開始ページ	109038
ISSN	07533322
NCID	AA10506249
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2019 The Authors. Published by Elsevier Masson SAS.
論文のバージョン	publisher
PubMed ID	31177060
DOI	10.1016/j.biopha.2019.109038
Web of Science KeyUT	000477804500018
関連URL	isVersionOf https://doi.org/10.1016/j.biopha.2019.109038

Rapid Acquisition of Alectinib Resistance in ALK-Positive Lung Cancer With High Tumor Mutation Burden

フルテキストURL	J_Thorac_Oncol_201907017.pdf
著者	Makimoto, Go\| Ohashi, Kadoaki\| Tomida, Shuta\| Nishii, Kazuya\| Matsubara, Takehiro\| Kayatani, Hiroe\| Higo, Hisao\| Ninomiya, Kiichiro\| Sato, Akiko\| Watanabe, Hiromi\| Kano, Hirohisa\| Ninomiya, Takashi\| Kubo, Toshio\| Rai, Kammei\| Ichihara, Eiki\| Hotta, Katsuyuki\| Tabata, Masahiro\| Toyooka, Shinichi\| Takata, Minoru\| Maeda, Yoshinobu\| Kiura, Katsuyuki\|
キーワード	ALK G1202R Alectinib Amphiregulin MET NSCLC
発行日	2019-07-30
出版物タイトル	Journal of Thoracic Oncology
巻	14巻
号	11号
出版者	Elsevier
開始ページ	2009
終了ページ	2018
ISSN	15560864
NCID	AA12058455
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2019 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.
論文のバージョン	author
PubMed ID	31374369
DOI	10.1016/j.jtho.2019.07.017
Web of Science KeyUT	000492678300025
関連URL	isVersionOf https://doi.org/10.1016/j.jtho.2019.07.017

A proposed simple screening method to determine relative contributions of CYP3A4 and CYP3A5 to drug metabolism in vitro

フルテキストURL	PMU8_41.pdf Fig.pdf Suppl.pdf
著者	Matsumoto, Jun\| Nakamura, Hiroyoshi\| San, Su Nwe\| Sato, Hikari\| Takezawa, Manami\| Kishi, Ryuto\| Kito, Yutaro\| Sugano, Junko\| Izuki, Mai\| Yanagisawa, Nao\| Ikeda, Naoki\| Saito, Yusuke\| Kato, Yoshinori\| Yamada, Harumi\| Fujiyoshi, Masachika\| Ariyoshi, Noritaka\|
キーワード	CYP3A CYP3A5*3 allele P450 Glo Assay system Pharmacokinetics Pharmacogenetics
発行日	2019-07-31
出版物タイトル	Personalized Medicine Universe
巻	8巻
出版者	Elsevier B.V.
開始ページ	41
終了ページ	44
ISSN	21867070
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
DOI	10.1016/j.pmu.2019.04.001
関連URL	isVersionOf https://doi.org/10.1016/j.pmu.2019.04.001

Convenient methodology for extraction and subsequent selective propagation of mouse melanocytes in culture from adult mouse skin tissue

フルテキストURL	fulltext.pdf
著者	Tomonobu, Nahoko\| Kinoshita, Rie\| Sumardika, I. Wayan\| Chen, Youyi\| Inoue, Yusuke\| Yamauchi, Akira\| Yamamoto, Ken-ichi\| Murata, Hitoshi\| Sakaguchi, Masakiyo\|
キーワード	Melanocytes Melanoma Metastasis Primary culture
発行日	2019-07
出版物タイトル	Biochemistry and Biophysics Reports
巻	18巻
出版者	Elsevier
開始ページ	100619
ISSN	24055808
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2019 The Authors.
論文のバージョン	publisher
PubMed ID	30899801
DOI	10.1016/j.bbrep.2019.100619
関連URL	isVersionOf https://doi.org/10.1016/j.bbrep.2019.100619

Critical role of the MCAM-ETV4 axis triggered by extracellular S100A8/A9 in breast cancer aggressiveness

フルテキストURL	fulltext.pdf
著者	Chen, Youyi\| Sumardika, I Wayan\| Tomonobu, Nahoko\| Kinoshita, Rie\| Inoue, Yusuke\| Iioka, Hidekazu\| Mitsui, Yosuke\| Saito, Ken\| Ruma, I Made Winarsa\| Sato, Hiroki\| Yamauchi, Akira\| Murata, Hitoshi\| Yamamoto, Ken-ichi\| Tomida, Shuta\| Shien, Kazuhiko\| Yamamoto, Hiromasa\| Soh, Junichi\| Futami, Junichiro\| Kubo, Miyoko\| Putranto, Endy Widya\| Murakami, Takashi\| Liu, Ming\| Hibino, Toshihiko\| Nishibori, Masahiro\| Kondo, Eisaku\| Toyooka, Shinichi\| Sakaguchi, Masakiyo\|
発行日	2019-07
出版物タイトル	Neoplasia
巻	21巻
号	7号
開始ページ	627
終了ページ	640
ISSN	1522-8002
NCID	AA11470191
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2019 The Authors.
論文のバージョン	publisher
PubMed ID	31100639
DOI	10.1016/j.neo.2019.04.006
Web of Science KeyUT	000472189700001
関連URL	isVersionOf https://doi.org/10.1016/j.neo.2019.04.006

Vision evaluation by functional observational battery, operant behavior test, and light/dark box test in retinal dystrophic RCS rats versus normal rats

フルテキストURL	Heliyon_5_6_01936.pdf
著者	Matsuo, Toshihiko\| Uchida, Tetsuya\| Yamashita, Koichiro\| Takei, Shigiko\| Ido, Daisuke\| Fujiwara, Atsushi\| Iino, Masahiko\| Oguchi, Masao\|
キーワード	Bioengineering Neuroscience Physiology Zoology
発行日	2019-06-30
出版物タイトル	Heliyon
巻	5巻
号	6号
出版者	Elsevier Science
開始ページ	e01936
ISSN	24058440
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2019 The Authors.
論文のバージョン	publisher
PubMed ID	31294104
DOI	10.1016/j.heliyon.2019.e01936
Web of Science KeyUT	000473818300195
関連URL	isVersionOf https://doi.org/10.1016/j.heliyon.2019.e01936

A novel insect-infecting virga/nege-like virus group and its pervasive endogenization into insect genomes

フルテキストURL	VirusRes_262_37.pdf FIG_S1-7_revised.pdf TableS1-3.pdf
著者	Kondo, Hideki\| Chiba, Sotaro\| Maruyama, Kazuyuki\| Andika, Ida Bagus\| Suzuki, Nobuhiro\|
キーワード	Bumblebee Endogenous viral element Evolution Insect Plant alpha-like virus Transcriptome shotgun assembly Whole genome shotgun assembly
発行日	2019-03-31
出版物タイトル	Virus Research
巻	262巻
出版者	Elsevier Science
開始ページ	37
終了ページ	47
ISSN	01681702
NCID	AA10642076
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2017 Elsevier B.V. All rights reserved.
論文のバージョン	author
PubMed ID	29169832
DOI	10.1016/j.virusres.2017.11.020
Web of Science KeyUT	000459523800007
関連URL	isVersionOf https://doi.org/10.1016/j.virusres.2017.11.020

Hyperoxia reduces salivary secretion by inducing oxidative stress in mice

フルテキストURL	AOB_98_38.pdf
著者	Tajiri, Ayako\| Higuchi, Hitoshi\| Miyawaki, Takuya\|
キーワード	Hyperoxia Hyposalivation Oxidative stress Saliva
発行日	2019-02-28
出版物タイトル	Archives of Oral Biology
巻	98巻
出版者	PERGAMON-ELSEVIER SCIENCE
開始ページ	38
終了ページ	46
ISSN	00039969
NCID	AA00548457
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2018 Elsevier Ltd. All rights reserved.
論文のバージョン	author
PubMed ID	30445238
DOI	10.1016/j.archoralbio.2018.11.001
Web of Science KeyUT	000457664000006
関連URL	isVersionOf https://doi.org/10.1016/j.archoralbio.2018.11.001

A Patient with Type 3 Autoimmune Polyglandular Syndrome who Developed Systemic Lupus Erythematosus 8 years after the Diagnosis of Autoimmune Hepatitis

JaLCDOI	10.18926/AMO/56940
フルテキストURL	73_4_367.pdf
著者	Mifune-Morioka, Tomoyo\| A. Uchida, Haruhito\| Fukushima, Kazuhiko\| Watanabe, Mayu\| Ouchi, Chihiro\| Mise, Koki\| Kawakita, Chieko\| Kano, Yuzuki\| Onishi, Akifumi\| Toma, Kishio\| Eguchi, Jun\| Wada, Nozomu\| Ikeda, Fusao\| Sasaki, Erika\| Suganami, Yu\| Kishida, Masayuki\| Sugiyama, Hitoshi\| Okada, Hiroyuki\| Wada, Jun\|
抄録	Eight years prior to her present admission, a 61-year-old Japanese woman was diagnosed with autoimmune hepatitis, slowly progressive insulin-dependent diabetes mellitus, and chronic thyroiditis; she had been treated with oral prednisolone (PSL). After she suddenly discontinued PSL, she newly developed systemic lupus erythematosus. A combination therapy of oral PSL and intravenous cyclophosphamide resulted in remission. She was finally diagnosed with autoimmune polyglandular syndrome (APS) type 3 (3A ,3B, 3D), complicated with four different autoimmune diseases. Since patients with type 3 APS may present many manifestations over a long period of time, they should be carefully monitored.
キーワード	autoimmune polyglandular syndrome type 3 systemic lupus erythematosus autoimmune hepatitis slowly progressive insulin-dependent diabetes mellitus chronic thyroiditis
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2019-08
巻	73巻
号	4号
出版者	Okayama University Medical School
開始ページ	367
終了ページ	372
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31439961

The Efficacy and Safety of Steroids for Preventing Postembolization Syndrome after Transcatheter Arterial Chemoembolization of Hepatocellular Carcinoma

JaLCDOI	10.18926/AMO/56935
フルテキストURL	73_4_333.pdf
著者	Kuwaki, Kenji\| Nouso, Kazuhiro\| Miyashita, Manabi\| Makino, Yasuhiro\| Hagihara, Hiroaki\| Moriya, Akio\| Adachi, Takuya\| Wada, Nozomu\| Yasunaka, Yuki\| Yasunaka, Tetsuya\| Takeuchi, Yasuto\| Onishi, Hideki\| Nakamura, Shinichiro\| Ikeda, Fusao\| Shiraha, Hidenori\| Takaki, Akinobu\| Okada, Hiroyuki\|
抄録	Steroids are often administered at the time of transcatheter arterial chemoembolization (TACE), a standard treatment of hepatocellular carcinoma (HCC), with the expectation of preventing postembolization syndrome. Here we investigated the precise effects of steroids on TACE. We prospectively enrolled 144 HCC patients from 10 hospitals who underwent TACE. Three hospitals used steroids (steroid group, n=77) and the rest did not routinely use steroids (control group, n=67). The occurrence of adverse events and the algetic degree at 1-5 days post-treatment were compared between the groups. Fever (grades 0-2) after TACE was significantly less in the steroid group (56/21/0) compared to the control group (35/29/3, p=0.005, Cochran-Armitage test for trend). The suppressive effect of steroids against fever was prominent in females (p=0.001). Vomiting (G0/G1/ G2-) was also less frequent in the steroid group (70/5/2) versus the control group (53/10/3), but not significantly (p=0.106). The algetic degree and the grade of hematological adverse events, including hyperglycemia, did not differ between the groups. We conclude that the administration of steroids was useful for the prevention of adverse events after TACE in patients with HCC.
キーワード	antipyretic hepatocellular carcinoma therapeutic chemoembolization steroid
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2019-08
巻	73巻
号	4号
出版者	Okayama University Medical School
開始ページ	333
終了ページ	339
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31439956

Successful Treatment of Metastatic Urothelial Carcinoma after Accurate Diagnosis by Immunohistochemistry

JaLCDOI	10.18926/AMO/56873
フルテキストURL	73_3_279.pdf
著者	Makimoto, Go\| Nishimori, Hisakazu\| Kondo, Reiko\| Yanai, Hiroyuki\| Sugimoto, Morito\| Oda, Naohiro\| Kubo, Toshio\| Hotta, Katsuyuki\| Tabata, Masahiro\| Kiura, Katsuyuki\| Maeda, Yoshinobu\|
抄録	Urothelial carcinoma usually presents with hematuria, but cases of multiple lymphadenopathy with elevated S-pancreas-1 antigen (SPan-1) levels have not been reported. A 62-year-old Japanese man with lymphadenopathies was diagnosed with an adenocarcinoma of unknown origin and transferred to our hospital for further diagnosis. Serum carbohydrate antigen 19-9 and SPan-1 levels were extremely elevated. Uroplakin III immunostaining was positive in the inguinal lymph node, and cystoscopy revealed the presence of invasive urothelial carcinoma. Treatment with cisplatin and gemcitabine promoted a complete metabolic response for > 4 years. The detection of uroplakin III and serum SPan-1 might help diagnose urothelial carcinoma.
キーワード	urothelial carcinoma uroplakin III s-pancreas-1 antigen carbohydrate antigen 19-9 chemotherapy
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2019-06
巻	73巻
号	3号
出版者	Okayama University Medical School
開始ページ	279
終了ページ	284
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31235978

Post-traumatic Articular Cartilage Lesions Increase at Second-look Arthroscopy Following Primary Anterior Cruciate Ligament Reconstruction

JaLCDOI	10.18926/AMO/56864
フルテキストURL	73_3_223.pdf
著者	Sugiu, Kazuhisa\| Furumatsu, Takayuki\| Kodama, Yuya\| Kamatsuki, Yusuke\| Okazaki, Yoshiki\| Okazaki, Yuki\| Hiranaka, Takaaki\| Ozaki, Toshifumi\|
抄録	Anterior cruciate ligament (ACL) reconstruction (ACLR) after ACL rupture improves the instability of the knee joint and decreases mechanical stress to the meniscus and articular cartilage. However, there are reports that post-traumatic osteoarthritis (PTOA) is observed over time following ACLR. In this study, we assessed changes in cartilage lesions by arthroscopic findings following anatomical double-bundle ACLR and at post-operative second-look arthroscopy about 14 months later. We retrospectively evaluated 37 knees in cases with patients <40 years of age who had undergone an anatomical double-bundle ACL reconstruction <1 year after ACL rupture injury from March 2012 to December 2016. Clinical results and arthroscopic cartilage/meniscal lesion were evaluated and compared between a cartilage lesion-detected group and intact-cartilage group. Surgery improved anteroposterior laxity and other clinical measures; however, cartilage lesions were detected at 11 sites during ACLR and at 54 sites at second-look arthroscopy. The periods from injury to second-look arthroscopy and from ACLR to second-look arthroscopy were significantly longer in the cartilage-lesion group (n=23) than in the intact-cartilage group (n=14). Conversely, 96% of meniscal damage observed during ACLR was cured at the time of second-look arthroscopy. Knee articular cartilage lesions after ACL rupture cannot be completely suppressed, even using the anatomical ACL reconstruction technique. This study suggested that articular cartilage lesions can progress to a level that can be confirmed arthroscopically at approximately 17 months after ACL injury. Therefore, in ACLR patients, the possibility of developing knee articular cartilage lesions and PTOA should be considered.
キーワード	anterior cruciate ligament reconstruction post-traumatic osteoarthritis meniscal lesion cartilage lesions second-look arthroscopy
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2019-06
巻	73巻
号	3号
出版者	Okayama University Medical School
開始ページ	223
終了ページ	228
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	31235969

Study on neural mechanisms of temporal expectation on a millisecond to second time scale

フルテキストURL	K0005979_abstract_review.pdf K0005979_fulltext.pdf
著者	徐之涵\|
発行日	2019-03-25
資料タイプ	学位論文
学位授与番号	甲第5979号
学位授与年月日	2019-03-25
学位・専攻分野	博士（工学）
授与大学	岡山大学
言語	英語

Characterization of Vibrio cholerae O1 strains that trace the origin of Haitian-like genetic traits

フルテキストURL	InfectGenetEvol_54_47.pdf
著者	Ghosh, Priyanka\| Kumar, Dhirendra\| Chowdhury, Goutam\| Singh, Puneeta\| Samanta, Prosenjit\| Dutta, Shanta\| Ramamurthy, T.\| Sharma, N. C.\| Sinha, Preety\| Prasad, Yogendra\| Shinoda, Sumio\| Mukhopadhyay, Asish K.\|
キーワード	Cholera Vibrio cholerae ctxAB promoter ctxB gyrA rstB rtxA tcpA
発行日	2017-10
出版物タイトル	Infection, Genetics and Evolution
巻	54巻
出版者	Elsevier Science
開始ページ	47
終了ページ	53
ISSN	15671348
NCID	AA11697619
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	28625543
DOI	10.1016/j.meegid.2017.06.015
Web of Science KeyUT	000411461400006
関連URL	isVersionOf https://doi.org/10.1016/j.meegid.2017.06.015