検索結果 1351 件
| フルテキストURL | Mol_Cell_Biol_28_7_2391.pdf |
|---|---|
| 著者 | Eguchi, Takanori| Kubota, Satoshi| Kawata, Kazumi| Mukudai, Yoshiki| Uehara, Junji| Ohgawara, Toshihiro| Ibaragi, Soichiro| Sasaki, Akira| Kuboki, Takuo| Takigawa, Masaharu| |
| 発行日 | 2008-04 |
| 出版物タイトル | Molecular and Cellular Biology |
| 巻 | 28巻 |
| 号 | 7号 |
| 出版者 | American Society for Microbiology |
| 開始ページ | 2391 |
| 終了ページ | 2413 |
| ISSN | 0270-7306 |
| NCID | AA10620925 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | publisher |
| PubMed ID | 18172013 |
| DOI | 10.1128/MCB.01288-07 |
| Web of Science KeyUT | 000254181400025 |
| 関連URL | isVersionOf https://doi.org/10.1128/MCB.01288-07 |
| JaLCDOI | 10.18926/AMO/56078 |
|---|---|
| フルテキストURL | 72_3_309.pdf |
| 著者 | Katayama, Satoshi| Takenaka, Tadasu| Nakamura, Aya| Sako, Sinichi| Bessho, Akihiro| Ohara, Nobuya| |
| 抄録 | Pulmonary tumor thrombotic microangiopathy (PTTM) is a fatal, malignancy-related respiratory complication; we herein report a PTTM case induced by metastatic prostate cancer. An 81-year-old Japanese man developed dyspnea. High-resolution computed tomography (HRCT) revealed ground-glass opacities spread across bilateral lung fields. Pulmonary microvascular aspiration cytology detected prostate cancer cells. As PTTM was highly suspected, docetaxel chemotherapy was performed immediately. His respiratory condition and HRCT findings improved temporarily, but he died approx. 6 weeks after admission. Autopsy showed fibrocellular intimal proliferation of small pulmonary arterioles, which confirmed the diagnosis of PTTM induced by prostate cancer. As in the present case, it is often difficult to confirm the presence of not only tumor embolization but also fibrocellular intimal proliferation before the patient’s death. |
| キーワード | autopsy dyspnea prostate neoplasm metastatic lung cancer thrombotic microangiopathy |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-06 |
| 巻 | 72巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 309 |
| 終了ページ | 313 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29926010 |
| JaLCDOI | 10.18926/AMO/56070 |
|---|---|
| フルテキストURL | 72_3_249.pdf |
| 著者 | Nakahara, Takako| Suemori, Shin-ichiro| Tsujioka, Takayuki| Kataoka, Mikio| Kataoka, Hiromi| Shibakura, Misako| Tohyama, Kaoru| |
| 抄録 | To investigate megakaryocyte (MK) DNA ploidy in various hematological diseases, fluorescence microscopy imaging system (FMI) can be used to analyze DNA ploidy with cell morphology at the single-cell level by using specialized image-processing software. Here we compared DNA ploidy obtained by FMI measured with that obtained flow cytometry (FCM). With FMI, we could evaluate the DNA ploidy in long-term preserved bone marrow smear samples after staining. We next analyzed the MK DNA ploidy in 42 bone marrow smear samples including 26 myeloid neoplasm cases, and we compared the DNA ploidy and platelet counts in the patients' peripheral blood; the production of platelets was significantly high compared to DNA ploidy in the myeloproliferative neoplasms group. The FMI method revealed that the patients with 5q- syndrome exhibited relatively low DNA ploidy despite high platelet counts, and this result suggested that increased DNA ploidy is not indispensable to abundant platelet production. The FMI method for DNA ploidy will be a useful tool to clarify the relationship between DNA ploidy and platelet production by MKs. |
| キーワード | fluorescence microscopy image analysis DNA ploidy megakaryocytes MDS with isolated del(5q) 5q- syndrome |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-06 |
| 巻 | 72巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 249 |
| 終了ページ | 256 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29926002 |
| JaLCDOI | 10.18926/AMO/56066 |
|---|---|
| フルテキストURL | 72_3_211.pdf |
| 著者 | Ikeda, Chikako| Yokota, Osamu| Miki, Tomoko| Takenoshita, Shintaro| Ishizu, Hideki| Terada, Seishi| Yamada, Norihito| |
| 抄録 | Neurodegenerative diseases in which tau accumulation plays a cardinal role in the pathogenic process are called tauopathies, and when tau isoforms having four repeats of the microtubule binding sites, four-repeat tau, are selectively accumulated as pathological hallmarks, the term four-repeat tauopathy is used. The major four-repeat tauopathies are progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and argyrophilic grain disease (AGD). Historically, neuronal cytopathologies, e.g., neurofibrillary tangles and ballooned neurons, were emphasized as characteristic lesions in PSP and CBD. Now, however, astrocytic tau pathologies, i.e., tufted astrocytes (TAs) and astrocytic plaques (APs), are considered to be highly disease-specific lesions. Although granular/fuzzy astrocytes (GFAs) frequently develop in the limbic system in AGD cases, the specificity is not conclusive yet. Some AGD cases have a few TAs, and to a lesser frequency, a few APs in the frontal cortex and subcortical nuclei. The number of astrocytic tau pathologies including TAs and GFAs increases with the progression of AGD. In this paper, histopathological features of astrocytic tau pathologies in PSP, CBD, and AGD are first reviewed. Then, recent findings regarding the coexistence of these tauopathies are summarized from a viewpoint of astrocytic tau pathologies. Further biochemical and pathological studies focusing tau-positive astrocytic lesions may be useful to increase understanding of the pathological process in four-repeat tauopathies and to develop novel therapeutic strategies for patients with these diseases. |
| キーワード | astrocytic plaque four-repeat tau globular glial inclusion granular fuzzy astrocyte tufted astrocyte |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-06 |
| 巻 | 72巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 211 |
| 終了ページ | 221 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29925998 |
| タイトル（別表記） | Metaplastic carcinoma of the breast : Two cases |
|---|---|
| フルテキストURL | 130_19.pdf |
| 著者 | 元木 崇之| 岩本 高行 | 大森 昌子| 松岡 順治| |
| 抄録 | We treated two patients with a rare metaplastic carcinoma of the breast. Patient 1：A 32-year-old woman presented with a rapidly growing mass（ 7cm） in her right breast. We diagnosed cT3N0M0 Stage IIB breast cancer and performed a radical resection. The pathological diagnosis was triple-negative metaplastic carcinoma with a Ki-67 value ＞30%. Postoperative adjuvant chemotherapy and radiotherapy were performed. Patient 2：A 66-year-old postmenopausal woman presented with a left breast mass. We diagnosed cT1N0M0 Stage I breast cancer and performed a radical resection. The pathological diagnosis was triple-negative metaplastic carcinoma with a Ki-67 value ＞30%. Postoperative adjuvant chemotherapy was performed. Patients 1 and 2 have achieved relapse-free survivals of 1 year＋2 months and 10 months, respectively. Metaplastic carcinoma of the breast is a rare tumor, and its prognosis is not favorable. The only available treatment is that used for invasive ductal carcinoma；a more specific treatment has not been established. The accumulation of further similar cases and the development of a novel effective treatment are desired. |
| キーワード | 乳癌（breast cancer） 化生癌（metaplastic carcinoma） 化学療法（chemotherapy） |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2018-04-02 |
| 巻 | 130巻 |
| 号 | 1号 |
| 開始ページ | 19 |
| 終了ページ | 23 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.130.13 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2018 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.130.13 |
| NAID | 130006730866 |
| タイトル（別表記） | A case of a mesenteric desmoid tumor preoperatively distinguished from imaging findings |
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| フルテキストURL | 130_13.pdf |
| 著者 | 河合 毅| 渡邉 貴紀| 信久 徹治 | 松本 祐介| 甲斐 恭平| 佐藤 四三| |
| 抄録 | A 73-year-old woman was admitted for closer investigation into an abdominal tumor. Abdominal ultra-sonography, CT, and magnetic resonance imaging showed a discrete abdominal tumor. Especially on MRI, the tumor appeared as a relatively ill-defined whorled soft-tissue thickening within the mesenteric fat, causing angulation or speculation of adjacent bowel mesentery. Surgery was performed under a presumptive diagnosis of a mesojejunum desmoid. The tumor was invading the transverse mesocolon and mesojejunum as well as the third portion of the duodenum and the middle colic artery, and it was close to but apart from the superior mesenteric artery. The tumor was resected, including removal of part of the duodenum and transverse colon. The specimen contained a white solid tumor measuring 14×12×8cm. Pathologic examination showed differentiated fibroblasts and copious collagen fibers. The tumor was negative for CD34, c-kit, S-100, and α-SMA, but positive for β-catenin. On the basis of these findings, we established a diagnosis of mesenteric desmoid tumor of the small intestine. The patient has been followed postoperatively for 2 years, no sign of recurrence, to date. |
| キーワード | 小腸間膜 (mesentery of the small intestine) デスモイド (desomoid) 腸間膜腫瘍 (mesenteric tumor) |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2018-04-02 |
| 巻 | 130巻 |
| 号 | 1号 |
| 開始ページ | 13 |
| 終了ページ | 18 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.130.13 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2018 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.130.13 |
| NAID | 130006730865 |
| フルテキストURL | PlosOne_2016_e0162394.PDF |
|---|---|
| 著者 | Arai, Kazuya| Eguchi, Takanori| Rahman, M. Mamunur| Sakamoto, Ruriko| Masuda, Norio| Nakatsura, Tetsuya| Calderwood, Stuart K.| Kozaki, Ken-ichi| Itoh, Manabu| |
| 発行日 | 2016-09-13 |
| 出版物タイトル | PLoS One |
| 巻 | 11巻 |
| 号 | 9号 |
| 出版者 | Public Library of Science |
| 開始ページ | e0162394 |
| ISSN | 1932-6203 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| 論文のバージョン | publisher |
| PubMed ID | 27622654 |
| DOI | 10.1371/journal.pone.0162394 |
| Web of Science KeyUT | 000383681000029 |
| 関連URL | isVersionOf https://doi.org/10.1371/journal.pone.0162394 |
| フルテキストURL | K0005773_abstract_review.pdf K0005773_summary.pdf K0005773_fulltext.pdf |
|---|---|
| 著者 | 中原 貴子| |
| 発行日 | 2018-03-23 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5773号 |
| 学位授与年月日 | 2018-03-23 |
| 学位・専攻分野 | 博士（保健学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| フルテキストURL | K0005679_abstract_review.pdf K0005679_summary.pdf K0005679_fulltext.pdf K0005679_table.xlsx |
|---|---|
| 著者 | 永喜多 敬奈| |
| 発行日 | 2018-03-23 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第5679号 |
| 学位授与年月日 | 2018-03-23 |
| 学位・専攻分野 | 博士（医学） |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| JaLCDOI | 10.18926/AMO/55860 |
|---|---|
| フルテキストURL | 72_2_185.pdf |
| 著者 | Morizane, Shin| Sugimoto, Saeko| Motoki, Takayuki| Katayama, Norihisa| Omori, Masako| Iwatsuki, Keiji| |
| 抄録 | Psoriasis is a common chronic inflammatory skin disorder that is characterized by scaly, erythematous, sharply demarcated plaques. The treatment for psoriasis has dramatically changed over the last 10 years with the introduction of biologics. However, the risk of cancer induced by biologics for psoriasis has not been fully analyzed, since these agents have such a short history of use. Here we report the case of a 74-year-old woman with psoriasis vulgaris and psoriatic arthritis complicated by breast cancer after systemic treatments including etretinate, cyclosporine, methotrexate, adalimumab, and ustekinumab. |
| キーワード | psoriasis systemic therapy biologics malignancy |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-04 |
| 巻 | 72巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 185 |
| 終了ページ | 187 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29674768 |
| JaLCDOI | 10.18926/AMO/55853 |
|---|---|
| フルテキストURL | 72_2_129.pdf |
| 著者 | Okura, Tomohiro| Fujii, Masakuni| Shiode, Junji| Ito, Yuri| Kojima, Toru| Nasu, Junichiro| Niguma, Takefumi| Yoshioka, Masao| Mimura, Tetsushige| Yamamoto, Kazuhide| |
| 抄録 | The impact of body mass index (BMI) on postoperative survival in Japanese patients with pancreatic cancer is unclear. We examined the relationship between preoperative BMI and the prognosis of Japanese patients who underwent surgery for pancreatic cancer to determine whether BMI affects these patients’ prognosis. Of the patients who underwent pancreatectomy between January 2004 and August 2015 at our institution, 246 were pathologically diagnosed with pancreatic tubular adenocarcinoma; the cancer was located in the pancreatic head (n=161) and in the body and tail (n=85). We classified the patients by BMI: underweight (n=22), normal weight (n=190), and overweight/obese (n=34) groups. We retrospectively analyzed medical records for patient characteristics, lesion location, disease stage, postoperative complications, chemotherapy, and prognosis. Lesion location, disease stage, postoperative complications, and chemotherapy were not significantly different among the BMI groups. The median survival times were as follows (days): all patients, 686; underweight, 485; normal weight, 694; and overweight/obese, 839. In a multivariate analysis, after adjusting for competing risk factors, low BMI was associated with an increased risk of death (normal weight: HR 0.58, p=0.038; overweight/obese: HR 0.54, p=0.059). High BMI was not found to be a postoperative factor for poor prognosis in Japanese pancreatic cancer patients. |
| キーワード | pancreatic cancer BMI prognosis surgery risk factor |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-04 |
| 巻 | 72巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 129 |
| 終了ページ | 135 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29674761 |
| JaLCDOI | 10.18926/AMO/55850 |
|---|---|
| フルテキストURL | 72_2_105.pdf |
| 著者 | Kato, Ryo| Iwamuro, Masaya| Hiraoka, Sakiko| Takashima, Shiho| Inokuchi, Toshihiro| Takahara, Masahiro| Kondo, Yoshitaka| Tanaka, Takehiro| Okada, Hiroyuki| |
| 抄録 | To analyze the clinical characteristics of patients with ulcerative colitis who have upper gastrointestinal lesions, we retrospectively reviewed the data of 216 patients with ulcerative colitis who underwent esophagogastroduodenoscopy at our institute in April 2008-March 2016. We investigated the endoscopic features and compared the clinical characteristics between the patients with and without upper gastrointestinal lesions. Forty-two patients (19.4%) had upper gastrointestinal lesions, including multiple erosions (n=18), bamboo joint-like appearance (n=17), mucosa with white spots (n=4), friable mucosa (n=2), ulcer (n=1), and purulent deposits within the mucosa (n=1) in the stomach and/or duodenum. Compared to the patients without upper gastrointestinal lesions, those with upper gastrointestinal lesions showed significantly more frequent extraintestinal manifestations (19.0% vs. 8.0%, p<0.05) and a significant history of colectomy (33.3% vs. 12.1%, p<0.01). There were no significant differences with regard to the sex ratio, age at esophagogastroduodenoscopy, gastrointestinal symptoms, time since the diagnosis of ulcerative colitis, type of colitis at the initial diagnosis of ulcerative colitis, or gastric atrophy between the groups. In conclusion, gastroduodenal lesions were identified in 19.4% of the patients with ulcerative colitis. Esophagogastroduodenoscopy is particularly recommended for ulcerative colitis patients who show extraintestinal manifestations and for those who have undergone a colectomy. |
| キーワード | ulcerative colitis esophagogastroduodenoscopy gastritis |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-04 |
| 巻 | 72巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 105 |
| 終了ページ | 113 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29674758 |
| JaLCDOI | 0 |
|---|---|
| フルテキストURL | J_Gastroenterol_Hepatol_62_4_925.pdf |
| 著者 | Horiguchi, higeru| Kato, Hironari| Shiraha, Hidenori| Tsutsumi, Koichiro| Yamamoto, Naoki| Matsumoto, Kazuyuki| Tomoda, Takeshi| Uchida, Daisuke| Akimoto, Yutaka| Mizukawa, Syou| Tanaka, Takehiro| Ichimura, Koichi| Takaki, Akinobu| Yagi, Takahito| Okada, Hiroyuki| |
| キーワード | WHO2010 dynamic CT microvessel density pancreatic neuroendocrine neoplasm pathological grade |
| 備考 | This is an Accepted Manuscript of an article published by John Wiley & Sons| |
| 発行日 | 2017-04 |
| 出版物タイトル | Journal of Gastroenterology and Hepatology |
| 巻 | 32巻 |
| 号 | 4号 |
| 出版者 | John Wiley & Sons |
| 開始ページ | 925 |
| 終了ページ | 931 |
| ISSN | 0815-9319 |
| NCID | AA10727383 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| 論文のバージョン | author |
| PubMed ID | 27637470 |
| DOI | 10.1111/jgh.13594 |
| Web of Science KeyUT | 000398534100030 |
| 関連URL | isVersionOf https://doi.org/10.1111/jgh.13594 |
| JaLCDOI | 10.18926/AMO/55659 |
|---|---|
| フルテキストURL | 72_1_23.pdf |
| 著者 | Fujiia, Masayoshi| Takata, Katsuyoshi| Chuang, Shih-Sung| Miyata-Takata, Tomoko| Ando, Midori| Sato, Yasuharu| Yoshino, Tadashi| |
| 抄録 | The gastrointestinal (GI) tract is the most frequently involved site of extranodal non-Hodgkin lymphomas, and diffuse large B-cell lymphoma (DLBCL) is the most common subtype occurring in the GI tract. TNFAIP3 (A20) genetic alterations were reported to be involved in DLBCL’s pathogenesis and a portion of GI-DLBCL cases harbor this alteration. However, the frequency and clinicopathological relations focusing on small and large intestinal DLBCL are unclear. Here, we examined A20 deletion and protein expression and analyzed the clinicopathological features of 52 cases of primary intestinal DLBCL. The most frequently involved site was the ileocecal region (75%), followed by small bowel (13.5%) and large intestine. Immunohistochemically, the ileocecal cases expressed BCL6 (p=0.027) and MUM1 (p=0.0001) significantly more frequently than the small intestinal cases. Six of 47 cases (13%) had A20 heterozygous deletion, whereas all 6 heterozygously deleted cases had detectable A20 protein expression. In summary, A20 abnormality was less prevalent among intestinal DLBCLs with some discordancy between gene deletion and protein expression. Although the A20 alteration status did not affect any clinicopathological characteristics in this series, further studies exploring alterations of A20 and other NF-κB components in primary intestinal DLBCL are needed. |
| キーワード | primary intestinal diffuse large B-cell lymphoma cell of origin A20 TNFAIP3 heterozygous deletion |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2018-02 |
| 巻 | 72巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 23 |
| 終了ページ | 30 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2018 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29463935 |
| タイトル（別表記） | Internationalization of medical education |
|---|---|
| フルテキストURL | 129_195.pdf |
| 著者 | 松川 昭博| |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2017-12-01 |
| 巻 | 129巻 |
| 号 | 3号 |
| 開始ページ | 195 |
| 終了ページ | 197 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.129.195 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2017 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.129.195 |
| NAID | 40021393940 |
| タイトル（別表記） | Two cases of solid-pseudopapillary neoplasm of the pancreas with contrasting imaging findings |
|---|---|
| フルテキストURL | 129_171.pdf |
| 著者 | 河合 毅| 遠藤 芳克| 渡邉 貴紀| 甲斐 恭平| 佐藤 四三| |
| 抄録 | A solid pseudo-papillary tumor of the pancreas is a rare neoplasm which mainly occurs in young women. Here, we report two cases of solid-pseudopapillary neoplasm of the pancreas (SPN) with contrasting imaging findings. One was a 59-year-old woman having no symptomatic complaint with a pancreatic cystic tumor in the tail. The tumor was 60 mm in diameter with a cyst composed of a calcified wall and low-density content which was poorly perfused on contrast-enhanced computed tomography (CT). We diagnosed SPN based on imaging findings and performed distal pancreatectomy. Histology revealed SPN, and the patient had two years of recurrence -free survival (RFS). The other case was a 34-year-old man with an asymptomatic solid tumor in the pancreatic tail. Contrast-enhanced CT showed low peripheral attenuation of a 25-mm solid tumor, with the main duct dilated distal from tumor. We diagnosed him with pancreatic cancer with atypical image findings. Pathological findings revealed SPN, and the patient had five years of RFS. Small-sized SPN is being increasingly recognized because of the recent advances in CT and MRI. We should consider SPN even if it occurs in a male, and endoscopic ultrasound -guided fine-needle aspiration has recently been reported to be useful in diagnosing SPN. |
| キーワード | 膵SPN（solid-pseudopapillary neoplasm of the pancreas） EUS-FNA（endoscopic ultrasound-guided fine needle aspiration） 成人男性（male） |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2017-12-01 |
| 巻 | 129巻 |
| 号 | 3号 |
| 開始ページ | 171 |
| 終了ページ | 177 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.129.171 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2017 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.129.171 |
| NAID | 40021393857 |
| タイトル（別表記） | The 2016 Incentive Award of the Okayama Medical Association in Neuroscience (2016 Niimi Prize) |
|---|---|
| フルテキストURL | 129_167.pdf |
| 著者 | 池田 智香子| |
| 出版物タイトル | 岡山医学会雑誌 |
| 発行日 | 2017-12-01 |
| 巻 | 129巻 |
| 号 | 3号 |
| 開始ページ | 167 |
| 終了ページ | 169 |
| ISSN | 0030-1558 |
| 関連URL | isVersionOf https://doi.org/10.4044/joma.129.167 references https://doi.org/10.1111/bpa.12319 |
| 言語 | 日本語 |
| 著作権者 | Copyright (c) 2017 岡山医学会 |
| 論文のバージョン | publisher |
| DOI | 10.4044/joma.129.167 |
| NAID | 40021393828 |
| JaLCDOI | 10.18926/AMO/55582 |
|---|---|
| フルテキストURL | 71_6_459.pdf |
| 著者 | Sakaguchi, Masakiyo| Kinoshita, Rie| Endy Widya Putranto| I Made Winarsa Ruma| I Wayan Sumardika| Youyi, Chen| Tomonobu, Naoko| Yamamoto, Ken-ichi| Murata, Hitoshi| |
| 抄録 | The receptor for advanced glycation end products (RAGE) is involved in inflammatory pathogenesis. It functions as a receptor to multiple ligands such as AGEs, HMGB1 and S100 proteins, activating multiple intracellular signaling pathways with each ligand binding. The molecular events by which ligand-activated RAGE controls diverse signaling are not well understood, but some progress was made recently. Accumulating evidence revealed that RAGE has multiple binding partners within the cytoplasm and on the plasma membrane. It was first pointed out in 2008 that RAGE’s cytoplasmic tail is able to recruit Diaphanous-1 (Dia-1), resulting in the acquisition of increased cellular motility through Rac1/Cdc42 activation. We also observed that within the cytosol, RAGE’s cytoplasmic tail behaves similarly to a Toll-like receptor (TLR4)-TIR domain, interacting with TIRAP and MyD88 adaptor molecules that in turn activate multiple downstream signals. Subsequent studies demonstrated the presence of an alternative adaptor molecule, DAP10, on the plasma membrane. The coupling of RAGE with DAP10 is critical for enhancing the RAGE-mediated survival signal. Interestingly, RAGE interaction on the membrane was not restricted to DAP10 alone. The chemotactic G-protein-coupled receptors (GPCRs) formyl peptide receptors1 and 2 (FPR1 and FPR2) also interacted with RAGE on the plasma membrane. Binding interaction between leukotriene B4 receptor 1 (BLT1) and RAGE was also demonstrated. All of the interactions affected the RAGE signal polarity. These findings indicate that functional interactions between RAGE and various molecules within the cytoplasmic area or on the membrane area coordinately regulate multiple ligand-mediated RAGE responses, leading to typical cellular phenotypes in several pathological settings. Here we review RAGE’s signaling diversity, to contribute to the understanding of the elaborate functions of RAGE in physiological and pathological contexts. |
| キーワード | receptor for advanced glycation end products RAGE adaptor protein signal transduction inflammatory pathogenesis |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-12 |
| 巻 | 71巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 459 |
| 終了ページ | 465 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29276218 |
| フルテキストURL | K0005596_other1.pdf |
|---|---|
| 著者 | Thar Htet San| Fujisawa, Masayoshi| Fushimi, Soichiro| Soe, Lamin| Ngu Wah Min| Yoshimura, Teizo| Ohara, Toshiaki| Myint Myint Yee| Oda, Shinsuke| Matsukawa , Akihiro| |
| キーワード | Breast cancer molecular subtypes Ki-67 expression Myanmar |
| 備考 | 学位審査副論文| |
| 発行日 | 2017-06-25 |
| 出版物タイトル | Asian Pacific journal of cancer prevention |
| 巻 | 18巻 |
| 号 | 6号 |
| 出版者 | Asian Pacific Organization for Cancer Prevention |
| 開始ページ | 1617 |
| 終了ページ | 1621 |
| ISSN | 1513-7368 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| 論文のバージョン | publisher |
| PubMed ID | 28670879 |
| DOI | 10.22034/APJCP.2017.18.6.1617 |
| 関連URL | isVersionOf https://doi.org/10.22034/APJCP.2017.18.6.1617 isPartOf http://ousar.lib.okayama-u.ac.jp/55521 |
| JaLCDOI | 10.18926/AMO/55436 |
|---|---|
| フルテキストURL | 71_5_391.pdf |
| 著者 | Iwamuro, Masaya| Takata, Katsuyoshi| Hayashi, Eiko| Kawano, Seiji| Hiraoka, Sakiko| Kawahara, Yoshiro| Yoshino, Tadashi| Okada, Hiroyuki| |
| 抄録 | To evaluate the usefulness of colonoscopy for the detection of ileal involvement in patients with intestinal follicular lymphoma, seventeen patients with intestinal follicular lymphoma who underwent colonoscopy and biopsy sampling from the terminal ileum were enrolled. The patients were divided into 2 groups: cases with ileal involvement (n=6) and cases without ileal involvement (n=11). Patients’ clinical backgrounds were compared between the two groups. Subsequently, 10 board-certified endoscopists independently evaluated the endoscopic pictures and determined whether the ileum was involved with follicular lymphoma. Infiltration of follicular lymphoma cells were identified in 6 patients (35.3%). Cases with positive ileal involvement were diagnosed with follicular lymphoma at a younger age than were cases without ileal involvement (55.4±7.4 vs. 68.1±10.3 years, p=0.011). Macroscopically, in patients with ileal involvement, there were multiple polypoid elevations smaller than 5 mm in 4 cases, single polypoid elevation smaller than 5 mm in 1 case, and single polypoid elevation larger than 5 mm in 1 case. In patients without ileal involvement, there were no lesions in the terminal ileum in 7 cases, and multiple polypoid elevations smaller than 5 mm were seen in 4 cases. The accuracy of the macroscopic evaluation by 10 board-certified endoscopists was 68.8%. Colonoscopy is particularly recommended during the initial workup of patients with follicular lymphoma diagnosed at age ≤ 60 years. The diagnosis of ileal involvement based on morphology alone is difficult; thus, biopsy and pathologic diagnosis are required for accurate diagnosis. |
| キーワード | follicular lymphoma colonoscopy ileal neoplasms terminal ileum small intestine |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-10 |
| 巻 | 71巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 391 |
| 終了ページ | 398 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 29042696 |