検索結果 - 岡山大学学術成果リポジトリ

The Evaluation of Immunohistochemical Markers and Thymic Cortical Microenvironmental Cells in Distinguishing Thymic Carcinoma from Type B3 Thymoma or Lung Squamous Cell Carcinoma

著者	Hayashi, Atsushi\| Fumon, Takumi\| Miki, Yukari\| Sato, Hiaki\| Yoshino, Tadashi\| Takahashi, Kiyoshi\|
発行日	2013-06
出版物タイトル	Journal of Clinical and Experimental Hematopathology
巻	53巻
号	1号
資料タイプ	学術雑誌論文

臨床病期Ⅲ期肺非小細胞癌に対する治療戦略

著者	木浦勝行\|
発行日	2013-08-01
出版物タイトル	岡山医学会雑誌
巻	125巻
号	2号
資料タイプ	学術雑誌論文

尿路上皮癌の病理診断―特に平坦病変について―

著者	柳井広之\|
発行日	2013-08-01
出版物タイトル	岡山医学会雑誌
巻	125巻
号	2号
資料タイプ	学術雑誌論文

十二指腸濾胞性リンパ腫はAIDの発現を欠くがBACH2の発現を有しmemoryB細胞としての性質を有する

著者	高田尚良\| 佐藤康晴\| 中村直哉\| 徳中摩美\| 三木由香里\| 菊池イアーラ幸江\| 五十嵐和彦\| 伊藤悦郎\| 張替秀雄\| 加藤省一\| 林詠子\| 岡剛史\| 星井嘉信\| 田利晶\| 岡田裕之\| Mohamado, ABD Alkader Lamia\| 前田嘉信\| 谷本光音\| 木下朝博\| 吉野正\|
発行日	2013-08-01
出版物タイトル	岡山医学会雑誌
巻	125巻
号	2号
資料タイプ	学術雑誌論文

外傷性脳傷害に対する抗HMGB-1抗体治療

著者	大熊佑\| 劉克約\| 和気秀徳\| 春間純\| 吉野正\| 大塚愛二\| 高橋英夫\| 森秀治\| 西堀正洋\| 伊達勲\|
発行日	2013-08-01
出版物タイトル	岡山医学会雑誌
巻	125巻
号	2号
資料タイプ	学術雑誌論文

Could salvage surgery after chemotherapy have clinical impact on cancer survival of patients with metastatic urothelial carcinoma?

著者	Bekku, Kensuke\| Saika, Takashi\| Kobayashi, Yasuyuki\| Kioshimoto, Ryo\| Kanbara, Taiki\| Nasu, Yasutomo\| Kumon, Hiromi\|
発行日	2013-02
出版物タイトル	International Journal of Clinical Oncology
巻	18巻
号	1号
資料タイプ	学術雑誌論文

Mechanomyographic activity in the human lateral pterygoid muscle during mandibular movement

著者	Kawakami, Shigehisa\| Kodama, Naoki\| Maeda, Naoto\| Sakamoto, Shunichi\| Oki, Kazuhiro\| Yanagi, Yoshinobu\| Asaumi, Jun-Ichi\| Maeda, Teruta\| Minagi, Shogo\|
発行日	2012-01-15
出版物タイトル	Journal of Neuroscience Methods
巻	203巻
号	1号
資料タイプ	学術雑誌論文

The clinical impact of pathological review on selection the treatment modality for localized prostate cancer in candidates for brachytherapy monotherapy

著者	岸本涼\|
発行日	2013-03-25
出版物タイトル
資料タイプ	学位論文

Prognostic impact of cancer stem cell-related markers in non-small cell lung cancer patients treated with induction chemoradiotherapy

著者	Shien, Kazuhiko\| Toyooka, Shinichi\| Ichimura, Kouichi\| Soh, Junichi\| Furukawa, Masashi\| Maki, Yuho\| Muraoka, Takayuki\| Tanaka, Norimitsu\| Ueno, Tsuyoshi\| Asano, Hiroaki\| Tsukuda, Kazunori\| Yamane, Masaomi\| Oto, Takahiro\| Kiura, Katsuyuki\| Miyoshi, Shinichiro\|
発行日	2012-07
出版物タイトル	Lung Cancer
巻	77巻
号	1号
資料タイプ	学術雑誌論文

p53 Expression in Pretreatment Specimen Predicts Response to Neoadjuvant Chemotherapy Including Anthracycline and Taxane in Patients with Primary Breast Cancer.

JaLCDOI	10.18926/AMO/50409
フルテキストURL	67_3_165.pdf
著者	Shien, Tadahiko\| Kinoshita, Takayuki\| Seki, Kunihiko\| Yoshida, Miwa\| Hojo, Takashi\| Shimizu, Chikako\| Taira, Naruto\| Doihara, Hiroyoshi\| Akashi-Tanaka, Sadako\| Tsuda, Hitoshi\| Fujiwara, Yasuhiro\|
抄録	While clinical and pathologic responses are important prognostic parameters, biological markers from core needle biopsy (CNB) are needed to predict neoadjuvant chemotherapy (NAC) response, to individualize treatment, and to achieve maximal efficacy. We retrospectively evaluated the cases of 183 patients with primary breast cancer who underwent surgery after NAC (anthracycline and taxane) at the National Cancer Center Hospital (NCCH). We analyzed EGFR, HER2, and p53 expression and common clinicopathological features from the CNB and surgical specimens of these patients. These biological markers were compared between sensitive patients (pathological complete response;pCR) and insensitive patients (clinical no change;cNC and clinical progressinve disease;cPD). In a comparison between the 9 (5%) sensitive patients and 30 (16%) insensitive patients, overexpression of p53 but not overexpression of either HER2 or EGFR was associated with a good response to NAC. p53 (p＝0.045) and histological grade 3 (p＝0.011) were important and significant predictors of the response to NAC. The correspondence rates for histological type, histological grade 3, ER, PgR, HER2, p53, and EGFR in insensitive patients between CNB and surgical specimens were 70%, 73%, 67%, 70%, 80%, 93%, and 73%. The pathologic response was significantly associated with p53 expression and histological grade 3. The correspondence rate of p53 expression between CNB and surgical specimens was higher than that of other factors. We conclude that the level of p53 expression in the CNB was an effective and reliable predictor of treatment response to NAC.
キーワード	breast cancer neoadjuvant chemotherapy predictors
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2013-06
巻	67巻
号	3号
出版者	Okayama University Medical School
開始ページ	165
終了ページ	170
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	23804139
Web of Science KeyUT	Pretreatment Specimen Predicts

Improvement of the Efficacy of 5-aminolevulinic Acid-mediated Photodynamic Treatment in Human Oral Squamous Cell Carcinoma HSC-4

JaLCDOI	10.18926/AMO/50408
フルテキストURL	67_3_153.pdf
著者	Yamamoto, Masanao\| Fujita, Hirofumi\| Katase, Naoki\| Inoue, Keiji\| Nagatsuka, Hitoshi\| Utsumi, Kozo\| Sasaki, Junzo\| Ohuchi, Hideyo\|
抄録	Ever since protoporphyrin IX (PpIX) was discovered to accumulate preferentially in cancer cells after 5-aminolevulinic acid (ALA) treatment, photodynamic treatment or therapy (PDT) has been developed as an exciting new treatment option for cancer patients. However, the level of PpIX accumulation in oral cancer is fairly low and insufficient for PDT. Ferrochelatase (FECH) and ATP-binding cassette transporter G2 (ABCG2) are known to regulate PpIX accumulation. In addition, serum enhances PpIX export by ABCG2. We investigated here whether and how inhibitors of FECH and ABCG2 and their combination could improve PpIX accumulation and PDT efficacy in an oral cancer cell line in serum-containing medium. ABCG2 inhibitor and the combination of ABCG2 and FECH inhibitors increased PpIX in the presence of fetal bovine serum (FBS) in an oral cancer cell line. Analysis of ABCG2 gene silencing also revealed the involvement of ABCG2 in the regulation of PpIX accumulation. Inhibitors of FECH and ABCG2, and their combination increased the efficiency of ALA-PDT even in the presence of FBS. ALA-PDT-induced cell death was accompanied by apoptotic events and lipid peroxidation. These results suggest that accumulation of PpIX is determined by the activities of ABCG2 and FECH and that treatment with a combination of their inhibitors improves the efficacy of PDT for oral cancer, especially in the presence of serum.
キーワード	5-aminolevulinic acid protoporphyrin IX oncology photodynamic therapy apoptosis
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2013-06
巻	67巻
号	3号
出版者	Okayama University Medical School
開始ページ	153
終了ページ	164
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	23804138
Web of Science KeyUT	000320747900004
関連URL	http://ousar.lib.okayama-u.ac.jp/metadata/50681

Redox-Active Protein Thioredoxin-1 Administration Ameliorates Influenza A Virus (H1N1)-Induced Acute Lung Injury in Mice

著者	Yashiro, Masato\| Tsukahara, Hirokazu\| Matsukawa, Akihiro\| Yamada, Mutsuko\| Fujii, Yosuke\| Nagaoka, Yoshiharu\| Tsuge, Mitsuru\| Yamashita, Nobuko\| Ito, Toshihiro\| Yamada, Masao\| Masutani, Hiroshi\|
発行日	2013-01
出版物タイトル	Critical Care Medicine
巻	41巻
号	1号
資料タイプ	学術雑誌論文

Detectability of colorectal neoplasia with fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomography and computed tomography (FDG-PET/CT)

著者	Hirakawa, Tomoko\| Kato, Jun\| Okumura, Yoshihiro\| Hori, Keisuke\| Takahashi, Sakuma\| Suzuki, Hideyuki\| Akita, Mitsuhiro\| Higashi, Reiji\| Saito, Shunsuke\| Kaji, Eisuke\| Uraoka, Toshio\| Hiraoka, Sakiko\| Yamamoto, Kazuhide\|
発行日	2012-02
出版物タイトル	Journal of Gastroenterology
巻	47巻
号	2号
資料タイプ	学術雑誌論文

肺癌と分子標的薬

著者	木浦勝行\| 谷本光音\|
発行日	2013-04-01
出版物タイトル	岡山医学会雑誌
巻	125巻
号	1号
資料タイプ	学術雑誌論文

Papillary Thyroid Carcinoma Arising from a Median Ectopic Thyroid with No Thyroglossal Duct Remnant

JaLCDOI	10.18926/AMO/49258
フルテキストURL	67_1_61.pdf
著者	Tachibana, Tomoyasu\| Orita, Yorihisa\| Fujisawa, Masayoshi\| Ogawara, Yuya\|
抄録	Thyroid carcinomas arising from ectopic thyroid tissue are uncommon;most of them arise from thyroid tissue in thyroglossal cysts. A rare case of a 66-year-old woman with papillary thyroid carcinoma arising from median ectopic thyroid tissue lacking a thyroglossal duct remnant is reported. The tumor was resected by Sistrunk's procedure, and the patient's postoperative course was good.
キーワード	ectopic thyroid papillary thyroid carcinoma thyroglossal duct remnant
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2013-02
巻	67巻
号	1号
出版者	Okayama University Medical School
開始ページ	61
終了ページ	64
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	23439510
Web of Science KeyUT	000316829900008

Silenced Expression of NFKBIA in Lung Adenocarcinoma Patients with a Never-smoking History

JaLCDOI	10.18926/AMO/49253
フルテキストURL	67_1_19.pdf
著者	Furukawa, Masashi\| Soh, Junichi\| Yamamoto, Hiromasa\| Ichimura, Kouichi\| Shien, Kazuhiko\| Maki, Yuho\| Muraoka, Takayuki\| Tanaka, Norimitsu\| Ueno, Tsuyoshi\| Asano, Hiroaki\| Tsukuda, Kazunori\| Toyooka, Shinichi\| Miyoshi, Shinichiro\|
抄録	Nuclear factor of κ-light polypeptide gene enhancer in B cells inhibitor α (NFKBIA), which is a tumor suppressor gene, was found to be silenced in lung adenocarcinomas. We examined NFKBIA expression, mutations in the EGFR and K-ras genes, and EML4-ALK fusion in 101 resected lung adenocarcinoma samples from never-smokers. NFKBIA expression was evaluated using immunohistochemistry. NFKBIA expression was negative in 16 of the 101 samples (15.8%). EGFR and K-ras mutations and EML4-ALK fusion were detected in 61 (60.5%), 1 (1.0%), and 2 (2.0%) of the 101 samples, respectively, in a completely mutually exclusive manner. Negative NFKBIA expression was observed significantly more frequently among the tumors with none of the three genetic alterations compared to those with such alterations (p＝0.009). In addition, negative NFKBIA expression was significantly more frequent among the EGFR-wild type samples compared to the EGFR-mutant samples (p＝0.013). In conclusion, NFKBIA expression was silenced in adenocarcinomas without EGFR/K-ras mutations or EML4-ALK fusion, suggesting that the silencing of NFKBIA may play an important role in the carcinogenesis of adenocarcinomas independent of EGFR/K-ras mutations or EML4-ALK fusion.
キーワード	never-smoker lung cancer adenocarcinoma nuclear factor of κ-light polypeptide gene enhancer in B cells inhibitor α epidermal growth factor receptor
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2013-02
巻	67巻
号	1号
出版者	Okayama University Medical School
開始ページ	19
終了ページ	24
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	23439505
Web of Science KeyUT	000316829900003
関連URL	http://ousar.lib.okayama-u.ac.jp/metadata/52534

著者	畑生俊光\|
発行日	2013-02-01
出版物タイトル	岡山大学農学部学術報告
巻	102巻
資料タイプ	紀要論文

Endometrial Polyps:MR Imaging Features

JaLCDOI	10.18926/AMO/49044
フルテキストURL	66_6_475.pdf
著者	Hase, Soichiro\| Mitsumori, Akihito\| Inai, Ryota\| Takemoto, Mitsuhiro\| Matsubara, Shinichiro\| Akamatsu, Nobuo\| Fujisawa, Masayoshi\| Joja, Ikuo\| Sato, Shuhei\| Kanazawa, Susumu\|
抄録	The purpose of this study is to evaluate the diagnostic usefulness of magnetic resonance imaging (MRI) characteristics of endometrial polyps in order to differentiate them from other endometrial lesions. MRI was retrospectively reviewed in 40 patients with pathologically proven endometrial polyps. Special attention was paid to the sizes, shapes, margins, internal structures, signal intensities, and post-contrast enhancement patterns. A central fibrous core, intratumoral cysts, and hemorrhage were seen in 30 (75%), 22 (55%), and 14 (35%) patients, respectively. The predominant signal intensity of the lesions showed iso-to slightly low signal intensity relative to the endometrium on T2-weighted images in 36 (90%), low signal intensity on diffusion-weighted images in 32 (80%), and strong or moderate enhancement on enhanced T1-weighted images in 28 patients (70%), respectively. In 32 (80%) patients, the endometrial polyps showed global or partial early enhancement. On dynamic study, rapid enhancement with a persistent strong enhancement pattern was seen in 17 (42.5%) and a gradually increasing enhancement pattern was seen in 17 patients (42.5%). These MRI features can be helpful to distinguish the endometrial polyps from various other endometrial lesions.
キーワード	endometrial polyp central fibrous core intratumoral cyst magnetic resonance imaging (MRI) uterus
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2012-12
巻	66巻
号	6号
出版者	Okayama University Medical School
開始ページ	475
終了ページ	485
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	23254582
Web of Science KeyUT	000312966100007
関連URL	http://ousar.lib.okayama-u.ac.jp/metadata/49723

32P-Postlabeling analysis of IQ, MelQx and PhIP adducts formed in vitro in DNA and polynucleotides and found in vivo in hepatic DNA from IQ-, MelQx- and PhIP-treated monkeys

著者	Snyderwine, Elizabeth G.\| Davis, Cindy D.\| Nouso, Kazuhiro\| RoIler, Peter P.\| Schut, Herman A.J.\|
発行日	1993-07
出版物タイトル	Carcinogenesis
巻	14巻
号	7号
資料タイプ	学術雑誌論文

術前化学療法により壁が菲薄化し組織学的寛解（pCR）となった巨大嚢胞内乳癌の１例

著者	今田孝子\| 松岡順治\| 元木崇之\| 岩本高行\| 大森昌子\| 伊波茂道\| 本後登志江\| 逸見典子\| 真壁幹夫\| 野上浩實\|
発行日	2012-12-03
出版物タイトル	岡山医学会雑誌
巻	124巻
号	3号
資料タイプ	学術雑誌論文