検索結果 18474 件
| JaLCDOI | 10.18926/bgeou/49312 |
|---|---|
| タイトル（別表記） | A Brief History of Melbourne -- Part Ⅰ |
| フルテキストURL | bgeou_152_075_084.pdf |
| 著者 | 野邊 政雄| |
| 抄録 | メルボルンのグレン・アイラ市に住む高齢女性に2005年と2006年に聞き取り調査をおこな い，彼女たちの語りを既に『研究集録』に発表した。その語りを理解することの助けとなる ように，メルボルンの歴史をまとめた。 |
| キーワード | オーストラリア メルボルン 都市史 郊外 |
| 出版物タイトル | 岡山大学大学院教育学研究科研究集録 |
| 発行日 | 2013-02-25 |
| 巻 | 152巻 |
| 開始ページ | 75 |
| 終了ページ | 84 |
| ISSN | 1883-2423 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120005232368 |
| JaLCDOI | 10.18926/bgeou/49310 |
|---|---|
| タイトル（別表記） | A Case Study Considering the Relationship between Children's Welfare and Injuries during School Hours and the Type of Clothing They Wear : Sports Wear Worn during P.E. Class for Example |
| フルテキストURL | bgeou_152_051_063.pdf |
| 著者 | 佐藤 園| 川村 佳子| 古川 育実| 松田 太希| 越宗 久美子| |
| 抄録 | 学校教育の今日的課題として，子どもの健康・安全保障のための教職員の役割の明確化と 学校全体の取組体制の整備・充実が求められている。本共同研究は，この課題を考えるため に，教師の指導の下で行われる教科の中で，最も傷病の発生数の多い「体育（保健体育）」 の授業時間に着用を義務づけられている体操服（学校体操服）を取り上げ，わが国の学校教 育と体操服の歴史的考察および岡山県における学校体操服の現状と評価を調査・被服科学の 実験結果から試み，“子どもの健康と安全を守るための環境としての被服と教職員の役割” について検討したものである。 |
| キーワード | 学校 子どもの健康・安全 環境としての被服 体操服 |
| 出版物タイトル | 岡山大学大学院教育学研究科研究集録 |
| 発行日 | 2013-02-25 |
| 巻 | 152巻 |
| 開始ページ | 51 |
| 終了ページ | 63 |
| ISSN | 1883-2423 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120005232366 |
| JaLCDOI | 10.18926/bgeou/49306 |
|---|---|
| タイトル（別表記） | An Appreciation of Daniel Deronda Chapter 22: Austen's Heritage and Eliot's Innovation |
| フルテキストURL | bgeou_152_011_021.pdf |
| 著者 | 福永 信哲| |
| 抄録 | The present paper aims at making clear how George Eliot owes a debt in style to Jane Austen in her character portrayal. Taking up Austen’s Emma and Eliot’s Daniel Deronda, we consider the qualities of prose style that are characteristic of the respective writers as seen in these novels. A comparative analysis of their discourses has brought to light a marked tendency on both sides to use negative expressions and the subjunctive. These common traits are surmised to meet an artistic challenge of creating ambiguity in the characters’psychological situations. Eliot, while inheriting Austen’s stylized English, utilizes scientific phraseology to give voice to the human drama in late nineteenth century England. Thus she adds physiological dimensions to what Austen has established. We attempt to prove this point on the basis of discourse analysis. |
| キーワード | 『エマ』 『ダニエル・デロンダ』 曖昧性 仮定法 否定語 |
| 出版物タイトル | 岡山大学大学院教育学研究科研究集録 |
| 発行日 | 2013-02-25 |
| 巻 | 152巻 |
| 開始ページ | 11 |
| 終了ページ | 21 |
| ISSN | 1883-2423 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120005232362 |
| JaLCDOI | 10.18926/bgeou/49305 |
|---|---|
| タイトル（別表記） | Effects of Individual Support Program for Freshman of Childcare Person |
| フルテキストURL | bgeou_152_001_009.pdf |
| 著者 | 西山 修| 片山 美香| |
| 抄録 | This study was aimed to investigate a support program on childcare contents“human relations” (Nishiyama, 2009) intended to intervene in the efficacy of childcare persons in terms of the pressing issue of how to cultivate efficacy in childcare persons in respect to children. Specifically, the program was aimed at bringing about a positive change in recognizing the practicability of the childcare persons in "bringing about the desired changes for cultivating efficacy around children" through measured diagnostic evaluations, setting of target action, and self monitoring. It was aimed at making qualitative improvements in childcare practice by providing increased motivation to the childcare persons. This study reported a section of the results of investigation on the effects of individual execution of the support program. Finally, consideration based on the result was added from the viewpoint of childcare persons support and the research topics in the future were shown. |
| キーワード | Childcare persons support program Childcare contents“ human relations” Efficacy Freshman Individual execution |
| 出版物タイトル | 岡山大学大学院教育学研究科研究集録 |
| 発行日 | 2013-02-25 |
| 巻 | 152巻 |
| 開始ページ | 1 |
| 終了ページ | 9 |
| ISSN | 1883-2423 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120005232361 |
| JaLCDOI | 10.18926/49303 |
|---|---|
| タイトル（別表記） | Game constitution in the recent student handball women competition － An analysis of the student woman higher rank team in 2007 and 2008－ |
| フルテキストURL | bhe_008_221_234.pdf |
| 著者 | 三浦 孝仁| 宮道 力| 兵藤 香織| 西畑 賢治| |
| 抄録 | This study was investigated that at examining the factor for winning with finding out the tendency of a student woman handball game in recent years ． Analysis was taken as the game of ８ teams of woman bests of the all Japan student handball championship in the 2008 fiscal year in the 2007 fiscal year． The result was as follows． ①In the student woman handball game of top class in recent years， the number of the goals was 26.6 points， the number of shots was 48.7 times， and the number of times of an attack was 67.9 times． In the number of times of an attack， it increased about 10 times per game from 15-year before， and speedy game deployment was developed． ② When it compared between a victory team and a loser team， the significant difference was seen in the number of shots （P< 0.05）， the number of the goals （P< 0.01）， the number of mistakes （P< 0.01）， the attack strike rate （P< 0.01）， the shot strike rate（ P< 0.01）， and the mistake rate（ P< 0.01）． ③ The strike rate of the set play was 28.1% in the loser team 42.1% in the victory team． Moreover， by the victory team， 23.2 %， in the loser team， it is 34.3 % and the significant difference（ P< 0.01） was seen about the rate of failure of the set play． |
| キーワード | ハンドボール ゲーム分析 |
| 出版物タイトル | 大学教育研究紀要 |
| 発行日 | 2012-12-31 |
| 巻 | 8巻 |
| 開始ページ | 221 |
| 終了ページ | 234 |
| ISSN | 1881-5952 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120005232360 |
| JaLCDOI | 10.18926/49300 |
|---|---|
| フルテキストURL | bhe_008_191_198.pdf |
| 著者 | Fujishima, Naomi| Ogino, Masaru| Otoshi, Junko| |
| 抄録 | 本稿は大学の授業における下位英語学習者へのe-learning 教材導入の有効性及びその効 果的活用方法を検証し考察するものである。E-learning導入後のTOEICスコア変化と自律 学習アンケート結果を、統制群を用いて比較検証した。その結果、distance learning モデ ルである実験群では、TOEIC スコアに大きな伸びがみられたが、GTEC テストを用いた統 制群では、実験群のような著しい伸びは認められなかった。また、実験群では自律学習の アンケート結果から「意識要因」のMotivation とIdeal-Self の値が微増していることが分 かった。本研究は学内COE 教育支援経費を受けての予備調査であるものの、教員の適切な 指導と助言があれば、下位英語学習者へのdistance learning モデルにおいて効果的に e-learning教材が活用出来ることを示唆している。 |
| キーワード | e-learning motivation autonomy distance learning English proficiency tests |
| 出版物タイトル | 大学教育研究紀要 |
| 発行日 | 2012-12-31 |
| 巻 | 8巻 |
| 開始ページ | 191 |
| 終了ページ | 198 |
| ISSN | 1881-5952 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120005232357 |
| JaLCDOI | 10.18926/49297 |
|---|---|
| フルテキストURL | bhe_008_151_162.pdf |
| 著者 | Nakamura, Ian| |
| 抄録 | Surviving, thriving, and evolving followed by further noticing, reflecting, and acting are some of the stages a teacher-researcher goes through before, during, and after the study leave experience. Having the opportunity to literally remove oneself from the daily concerns, routines, and habits entrenched in one’s local institutional context for an extended period of time（ e.g., six months） is an experience like no other. Blood donation campaigns call giving blood ‘a gift that keeps on giving’. While the majority of people in our profession do carry on with their work quite well without ever going on a study leave （or donating blood）, an important revelation that I have had is: a study leave is also ‘a gift that keeps on giving’. |
| キーワード | study leave professional development reflective learning |
| 出版物タイトル | 大学教育研究紀要 |
| 発行日 | 2012-12-31 |
| 巻 | 8巻 |
| 開始ページ | 151 |
| 終了ページ | 162 |
| ISSN | 1881-5952 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120005232354 |
| JaLCDOI | 10.18926/49291 |
|---|---|
| タイトル（別表記） | What Do Learners Expect to Study in Intermediate-level Japanese Language Class?: A Survey in a Higher Education Institution |
| フルテキストURL | bhe_008_061_072.pdf |
| 著者 | 内丸 裕佳子| |
| 抄録 | 本稿は，アンケート調査を通じて高等教育機関で学ぶ学習者の中級レベルに対する学習 ニーズを明らかにすることを目的とする。アンケート調査結果は４点にまとめられる。（１） 教科書の説明および内容：初級に比べ評価が低くなる。母語による解説が望まれている。 （２）学習項目：アカデミックな日本語，日常生活での日本語の両方に対するニーズがある。 会話学習への要望が最も多く，次いで文法・文型，語彙が同数だった。（３）教え方に対 する要望：①既習表現と比較しながら説明する。②文型・表現は共通する意味・用法でま とめて効率的に教える。③文型・語彙の硬さ・柔らかさの区別を示す。（４）教室活動に 対する要望：短い会話練習，作文，ゲーム要素を取り入れた練習も増やす。 |
| キーワード | 中級プログラム 学習ニーズ 学習項目 教え方 教室活動 |
| 出版物タイトル | 大学教育研究紀要 |
| 発行日 | 2012-12-31 |
| 巻 | 8巻 |
| 開始ページ | 61 |
| 終了ページ | 72 |
| ISSN | 1881-5952 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120005232348 |
| JaLCDOI | 10.18926/49288 |
|---|---|
| タイトル（別表記） | Problems Related to EPOK Students from Partner Universities: From the Records of an International Student Advisor’s Office |
| フルテキストURL | bhe_008_011_028.pdf |
| 著者 | 岡 益巳| |
| 抄録 | The EPOK （English Program Okayama） exchange program officially started in April, 1999 after a one-year trial. By the end of the 2011 academic year Okayama University had accepted 199 students in total from partner universities. Since October, 1999, the author has been keeping records of EPOK students’ problems brought into the International Student Advisor’s Office by EPOK coordinators. In this paper, 57 cases of problems will be introduced and examined as the author believes that there is a need for the university to clarify the problems encountered by EPOK students over the past twelve years in order to promote globalization. |
| 出版物タイトル | 大学教育研究紀要 |
| 発行日 | 2012-12-31 |
| 巻 | 8巻 |
| 開始ページ | 11 |
| 終了ページ | 28 |
| ISSN | 1881-5952 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120005232345 |
| タイトル（別表記） | A Study on Law-Related Education (4) |
|---|---|
| フルテキストURL | olj_062_3_485_499.pdf |
| 著者 | 辻 博明| |
| 出版物タイトル | 岡山大學法學會雜誌 |
| 発行日 | 2013-02-28 |
| 巻 | 62巻 |
| 号 | 3号 |
| 開始ページ | 485 |
| 終了ページ | 499 |
| ISSN | 0386-3050 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120005232342 |
| フルテキストURL | olj_062_3_620_593.pdf |
|---|---|
| 著者 | 大森 秀臣| |
| 出版物タイトル | 岡山大學法學會雜誌 |
| 発行日 | 2013-02-28 |
| 巻 | 62巻 |
| 号 | 3号 |
| 開始ページ | 620 |
| 終了ページ | 593 |
| ISSN | 0386-3050 |
| 言語 | 英語 |
| 論文のバージョン | publisher |
| NAID | 120005232340 |
| JaLCDOI | 10.18926/AMO/49258 |
|---|---|
| フルテキストURL | 67_1_61.pdf |
| 著者 | Tachibana, Tomoyasu| Orita, Yorihisa| Fujisawa, Masayoshi| Ogawara, Yuya| |
| 抄録 | Thyroid carcinomas arising from ectopic thyroid tissue are uncommon;most of them arise from thyroid tissue in thyroglossal cysts. A rare case of a 66-year-old woman with papillary thyroid carcinoma arising from median ectopic thyroid tissue lacking a thyroglossal duct remnant is reported. The tumor was resected by Sistrunk's procedure, and the patient's postoperative course was good. |
| キーワード | ectopic thyroid papillary thyroid carcinoma thyroglossal duct remnant |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2013-02 |
| 巻 | 67巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 61 |
| 終了ページ | 64 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23439510 |
| Web of Science KeyUT | 000316829900008 |
| JaLCDOI | 10.18926/AMO/49257 |
|---|---|
| フルテキストURL | 67_1_55.pdf |
| 著者 | Shimo, Tsuyoshi| Nishiyama, Akiyoshi| Jinno, Tokiari| Sasaki, Akira| |
| 抄録 | In this article, we report the successful surgical treatment of a patient, 34 years of age, who had a severe gummy smile and a class II malocclusion. The patient had an 11-mm gingival exposure during full smile and a convex profile. A LeFort I osteotomy combined with a horseshoe osteotomy was used for the superior repositioning of the maxilla;then, an intraoral vertical ramus osteotomy (IVRO) and genioplasty were performed for mandibular advancement. The maxilla was acceptably impacted 8mm at the first incisor and 5mm at the first molar. Both the occlusion and facial appearance were significantly improved by this surgical-orthodontic treatment. Our results suggest that the combination of a horseshoe osteotomy with a LeFort I osteotomy is a useful technique for reliable superior repositioning of the maxilla. |
| キーワード | LeFort I osteotomy horseshoe osteotomy gummy smile |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2013-02 |
| 巻 | 67巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 55 |
| 終了ページ | 60 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23439509 |
| Web of Science KeyUT | 000316829900007 |
| JaLCDOI | 10.18926/AMO/49256 |
|---|---|
| フルテキストURL | 67_1_45.pdf |
| 著者 | Hashizume, Hiroaki| Sato, Ken| Yamazaki, Yuichi| Horiguchi, Norio| Kakizaki, Satoru| Mori, Masatomo| |
| 抄録 | In patients with nonalcoholic steatohepatitis (NASH), the prevalence of cirrhosis is higher among women than men, and hepatocellular carcinoma (HCC) develops mainly in the cirrhotic stage among women. However, the long-term outcomes in female patients with NASH have not been fully elucidated, and age, gender and BMI were not simultaneously adjusted in previous studies on the prognosis of NASH. To elucidate the outcomes in female patients with NASH, we prospectively compared NASH patients with advanced fibrosis (advanced NASH) with hepatitis C virus-related advanced fibrosis (advanced CHC) patients and NASH patients with mild fibrosis (mild NASH) using study cohorts that were adjusted for body mass index (BMI) in addition to age. The median follow-up period was 92.5 months. Liver-related complication-free survival was significantly reduced in the advanced NASH group compared to the mild NASH group. No liver-related complications developed in the mild NASH group. The overall survival, liver-related complication- and cardiovascular/cerebrovascular disease-free survival were not significantly different between the advanced NASH and CHC groups. Female patients with NASH and advanced fibrosis may have a less favorable prognosis for liver-related complications than the matched cohorts with NASH and mild fibrosis, but may have a similar prognosis to the matched cohorts with CHC. |
| キーワード | nonalcoholic steatohepatitis chronic hepatitis C prognosis female |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2013-02 |
| 巻 | 67巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 45 |
| 終了ページ | 53 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23439508 |
| Web of Science KeyUT | 000316829900006 |
| JaLCDOI | 10.18926/AMO/49255 |
|---|---|
| フルテキストURL | 67_1_35.pdf |
| 著者 | Watanabe, Masutaka| Arita, Seizaburo| Hashizume, Hiroyuki| Honda, Mitsugi| Nishida, Keiichiro| Ozaki, Toshifumi| |
| 抄録 | The purpose of this study was to quantitatively evaluate Akahori's preoperative classification of cubital tunnel syndrome. We analyzed the results for 57 elbows that were treated by a simple decompression procedure from 1997 to 2004. The relationship between each item of Akahori's preoperative classification and clinical stage was investigated based on the parameter distribution. We evaluated Akahori's classification system using multiple regression analysis, and investigated the association between the stage and treatment results. The usefulness of the regression equation was evaluated by analysis of variance of the expected and observed scores. In the parameter distribution, each item of Akahori's classification was mostly associated with the stage, but it was difficult to judge the severity of palsy. In the mathematical evaluation, the most effective item in determining the stage was sensory conduction velocity. It was demonstrated that the established regression equation was highly reliable (R＝0.922). Akahori's preoperative classification can also be used in postoperative classification, and this classification was correlated with postoperative prognosis. Our results indicate that Akahori's preoperative classification is a suitable system. It is reliable, reproducible and well-correlated with the postoperative prognosis. In addition, the established prediction formula is useful to reduce the diagnostic complexity of Akahori's classification. |
| キーワード | cubital tunnel syndrome ulnar nerve Akahoriʼs classification multiple regression analysis |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2013-02 |
| 巻 | 67巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 35 |
| 終了ページ | 44 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23439507 |
| Web of Science KeyUT | 000316829900005 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/50647 |
| JaLCDOI | 10.18926/AMO/49254 |
|---|---|
| フルテキストURL | 67_1_25.pdf |
| 著者 | Ika, Katsuhiko| Suzuki, Etsuji| Mitsuhashi, Toshiharu| Takao, Soshi| Doi, Hiroyuki| |
| 抄録 | The purpose of this study was to examine the association between shift work and diabetes mellitus by separating shift workers according to the intensity of their shift work (seasonal shift work and continuous shift work). Between May and October 2009, we collected data from annual health checkups and questionnaires at a manufacturing company in Shizuoka, Japan. Questionnaires were returned by 1,601 workers (response rate:96.2%, men/women＝1,314/287). Diabetes mellitus was defined as hemoglobin A1c≥6.5% and fasting blood sugar≥126mg/dl. After exclusions, which included all the women and clerical workers because they did not work in shifts, we analyzed 475 skilled male workers. After adjusting for age, smoking status, frequency of alcohol consumption, and cohabitation status, odds ratios for diabetes mellitus were 0.98 (95% confidence interval [CI]:0.28-4.81) and 2.10 (95% CI:0.77-5.71) among seasonal shift workers and continuous shift workers, respectively, compared with non-shift workers. In an age-stratified analysis (＜45 years vs.≥45 years), the association between continuous shift work and diabetes mellitus was more pronounced among older participants. Compared with non-shift workers, the risk of diabetes mellitus was increased among continuous shift workers, whereas its effect is limited among seasonal shift workers. |
| キーワード | cross-sectional study diabetes mellitus intensity Japan shift work |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2013-02 |
| 巻 | 67巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 25 |
| 終了ページ | 33 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23439506 |
| Web of Science KeyUT | 000316829900004 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/50693 |
| JaLCDOI | 10.18926/AMO/49253 |
|---|---|
| フルテキストURL | 67_1_19.pdf |
| 著者 | Furukawa, Masashi| Soh, Junichi| Yamamoto, Hiromasa| Ichimura, Kouichi| Shien, Kazuhiko| Maki, Yuho| Muraoka, Takayuki| Tanaka, Norimitsu| Ueno, Tsuyoshi| Asano, Hiroaki| Tsukuda, Kazunori| Toyooka, Shinichi| Miyoshi, Shinichiro| |
| 抄録 | Nuclear factor of κ-light polypeptide gene enhancer in B cells inhibitor α (NFKBIA), which is a tumor suppressor gene, was found to be silenced in lung adenocarcinomas. We examined NFKBIA expression, mutations in the EGFR and K-ras genes, and EML4-ALK fusion in 101 resected lung adenocarcinoma samples from never-smokers. NFKBIA expression was evaluated using immunohistochemistry. NFKBIA expression was negative in 16 of the 101 samples (15.8%). EGFR and K-ras mutations and EML4-ALK fusion were detected in 61 (60.5%), 1 (1.0%), and 2 (2.0%) of the 101 samples, respectively, in a completely mutually exclusive manner. Negative NFKBIA expression was observed significantly more frequently among the tumors with none of the three genetic alterations compared to those with such alterations (p＝0.009). In addition, negative NFKBIA expression was significantly more frequent among the EGFR-wild type samples compared to the EGFR-mutant samples (p＝0.013). In conclusion, NFKBIA expression was silenced in adenocarcinomas without EGFR/K-ras mutations or EML4-ALK fusion, suggesting that the silencing of NFKBIA may play an important role in the carcinogenesis of adenocarcinomas independent of EGFR/K-ras mutations or EML4-ALK fusion. |
| キーワード | never-smoker lung cancer adenocarcinoma nuclear factor of κ-light polypeptide gene enhancer in B cells inhibitor α epidermal growth factor receptor |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2013-02 |
| 巻 | 67巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 19 |
| 終了ページ | 24 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23439505 |
| Web of Science KeyUT | 000316829900003 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/52534 |
| JaLCDOI | 10.18926/AMO/49252 |
|---|---|
| フルテキストURL | 67_1_9.pdf |
| 著者 | Fatmawati, Ni Nengah Dwi| Sakaguchi, Yoshihiko| Suzuki, Tomonori| Oda, Masataka| Shimizu, Kenta| Yamamoto, Yumiko| Sakurai, Jun| Matsushita, Osamu| Oguma, Keiji| |
| 抄録 | Clostridium botulinum type C and D strains recently have been found to produce PLC on egg yolk agar plates. To characterize the gene, enzymatic and biological activities of C. botulinum PLCs (Cb-PLCs), the cb-plc genes from 8 strains were sequenced, and 1 representative gene was cloned and expressed as a recombinant protein. The enzymatic and hemolytic activities of the recombinant Cb-PLC were measured and compared with those of the Clostridium perfringens alpha-toxin. Each of the eight cb-plc genes encoded a 399 amino acid residue protein preceded by a 27 residue signal peptide. The protein consists of 2 domains, the N- and C-domains, and the overall amino acid sequence identity between Cb-PLC and alpha-toxin was greater than 50%, suggesting that Cb-PLC is homologous to the alpha-toxin. The key residues in the N-domain were conserved, whereas those in the C-domain which are important in membrane interaction were different than in the alpha-toxin. As expected, Cb-PLC could hydrolyze egg yolk phospholipid, p-nitrophenylphosphorylcholine, and sphingomyelin, and also exhibited hemolytic activity;however, its activities were about 4- to over 200-fold lower than those of alpha-toxin. Although Cb-PLC showed weak enzymatic and biological activities, it is speculated that Cb-PLC might play a role in the pathogenicity of botulism or for bacterial survival. |
| キーワード | botulinum phospholipase C botulinum toxin phospholipase C activity sphingomyelinase activity hemolytic activity |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2013-02 |
| 巻 | 67巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 9 |
| 終了ページ | 18 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23439504 |
| Web of Science KeyUT | 000316829900002 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/49731 |
| JaLCDOI | 10.18926/AMO/49251 |
|---|---|
| フルテキストURL | 67_1_1.pdf |
| 著者 | Nishimori, Hisakazu| Maeda, Yoshinobu| Tanimoto, Mitsune| |
| 抄録 | Graft-versus-host disease (GVHD) is a major complication after allogeneic hematopoietic stem cell transplantation. Chronic GVHD often presents with clinical manifestations that resemble those observed in autoimmune diseases. Standard treatment is 1-2mg/kg/day of prednisone or an equivalent dose of methylprednisolone, with continued administration of a calcineurin inhibitor for steroid sparing. However, the prognosis of steroid-refractory chronic GVHD remains poor. Classically, chronic GVHD was said to involve predominantly Th2 responses. We are now faced with a more complex picture, involving possible roles for thymic dysfunction, transforming growth factor-β (TGF-β) and platelet-derived growth factor (PDGF), B cells and autoantibodies, and Th1/Th2/Th17 cytokines, as well as regulatory T cells (Tregs), in chronic GVHD. More detailed research on the pathophysiology of chronic GVHD may facilitate the establishment of novel strategies for its prevention and treatment. |
| キーワード | chronic GVHD Th17 Am80 regulatory T cell (Treg) steroid-refractory |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2013-02 |
| 巻 | 67巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 1 |
| 終了ページ | 8 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2013 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 23439503 |
| Web of Science KeyUT | 000316829900001 |
| JaLCDOI | 10.18926/ESR/49212 |
|---|---|
| タイトル（別表記） | A case study on persistent appearance of the ensemble of precipitation bands in the warm sector of the Baiu front in the western Japan around 19 June 2001 |
| フルテキストURL | esr_019_1_039_050.pdf |
| 著者 | 合田 泰弘| 加藤 内藏進| 塚本 修| |
| 抄録 | A case study on persistent appearance of the ensemble of precipitation bands in the warm sector of the Baiu front in Kyushu District, the western part of Japan around 19 June 2001 was performed based on the operational observational data. Around 00UTC (09JST) 19 June when the Baiu front on the surface weather map was still located about a few 100kms to the north of Kyushu, the number and the total area of the meso-β or γ-scale line-shaped precipitation bands increased around Kyushu rapidly. These precipitation bands had been sustained there and gradually gathered each other to change into the Baiu frontal precipitation zone extending from the northern Kyushu to Seto-Naikai (Seto Inland Sea) around 09UTC (18JST) 19 June (the intense rainfall zone was still located in the warm sector of the Baiu front). Until ~09UTC (18JST) 19 June, the moist air flow with the latently unstable stratification had been sustained around Kyushu corresponding to the low-level southerly wind toward the surface Baiu front to the north of Kyushu. This large-scale situation would contribute greatly to the maintenance of the ensemble of the line-shaped precipitation bands in the warm sector of the Baiu front. |
| キーワード | ensemble of line-shaped precipitation bands precipitation in the warm sector of the Baiu front Baiu fronal rainfall |
| 出版物タイトル | Okayama University Earth Science Report |
| 発行日 | 2012-12-26 |
| 巻 | 19巻 |
| 号 | 1号 |
| 開始ページ | 39 |
| 終了ページ | 50 |
| ISSN | 1340-7414 |
| 言語 | 日本語 |
| 著作権者 | © 2012 by Okayama University Earth Science Reports Editorial Committee All Rights Reserved |
| 論文のバージョン | publisher |
| NAID | 120005232330 |