検索結果 - 岡山大学学術成果リポジトリ

The Genetic Diversity of Helicobacter pylori Virulence Genes Is Not Associated with Gastric Atrophy Progression

JaLCDOI	10.18926/AMO/49667
フルテキストURL	67_2_93.pdf
著者	Kita, Masahide\| Yokota, Kenji\| Okada, Hiroyuki\| Take, Susumu\| Takenaka, Ryuta\| Kawahara, Yoshiro\| Oguma, Keiji\| Matsushita, Osamu\| Yamamoto, Kazuhide\|
抄録	Atrophy of the gastric mucosa is a precursor of intestinal-type gastric cancer, and Helicobacter pylori infection causes atrophic gastritis. The aim of this study was to determine whether the genetic diversity of H. pylori virulence genes is associated with the development and progression of gastric atrophy in humans. We isolated and cultured H. pylori strains from patients with gastric ulcer and duodenal ulcer accompanied by atrophic gastritis in background mucosa. H. pylori strains were stored at －80℃ prior to the experiments being carried out. We analyzed iceA, babA, vacA, cagA, and cagE genes by PCR. The cagA gene was analyzed through sequencing of the C-terminal region containing the EPIYA motif, which is related to tyrosine phosphorylation. Severe atrophy was observed in patients with gastric ulcer. The major phenotype of the vacA gene was s1c/m1 (93ｵ). The cagA gene was detected in all strains. The cagE gene was not detected in 2 and 5 strains from the mild cases and severe cases, respectively. The major cagA EPIYA motif, which is amino acids repeat in the C terminus, was the A-B-D type (44 of 58 strains). The virulence genes were not statistically associated with the severity of atrophy in the background gastric mucosa in humans. Not only identification of bacterial virulence factors but also studies of the host response will be necessary to investigate the progression of gastric atrophy and subsequent cancer development in humans.
キーワード	Helicobacter pylori virulence genes chronic atrophic gastritis
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2013-04
巻	67巻
号	2号
出版者	Okayama University Medical School
開始ページ	93
終了ページ	98
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	23603925
Web of Science KeyUT	000317801700003
関連URL	http://ousar.lib.okayama-u.ac.jp/metadata/52508

Stereoscopic Three-Dimensional Images of an Anatomical Dissection of the Eyeball and Orbit for Educational Purposes

JaLCDOI	10.18926/AMO/49666
フルテキストURL	67_2_87.pdf
著者	Matsuo, Toshihiko\| Takeda, Yoshimasa\| Ohtsuka, Aiji\|
抄録	The purpose of this study was to develop a series of stereoscopic anatomical images of the eye and orbit for use in the curricula of medical schools and residency programs in ophthalmology and other specialties. Layer-by-layer dissection of the eyelid, eyeball, and orbit of a cadaver was performed by an ophthalmologist. A stereoscopic camera system was used to capture a series of anatomical views that were scanned in a panoramic three-dimensional manner around the center of the lid fissure. The images could be rotated 360 degrees in the frontal plane and the angle of views could be tilted up to 90 degrees along the anteroposterior axis perpendicular to the frontal plane around the 360 degrees. The skin, orbicularis oculi muscle, and upper and lower tarsus were sequentially observed. The upper and lower eyelids were removed to expose the bulbar conjunctiva and to insert three 25-gauge trocars for vitrectomy at the location of the pars plana. The cornea was cut at the limbus, and the lens with mature cataract was dislocated. The sclera was cut to observe the trocars from inside the eyeball. The sclera was further cut to visualize the superior oblique muscle with the trochlea and the inferior oblique muscle. The eyeball was dissected completely to observe the optic nerve and the ophthalmic artery. The thin bones of the medial and inferior orbital wall were cracked with a forceps to expose the ethmoid and maxillary sinus, respectively. In conclusion, the serial dissection images visualized aspects of the local anatomy specific to various procedures, including the levator muscle and tarsus for blepharoptosis surgery, 25-gauge trocars as viewed from inside the eye globe for vitrectomy, the oblique muscles for strabismus surgery, and the thin medial and inferior orbital bony walls for orbital bone fractures.
キーワード	stereoscopic camera-captured images education local anatomical dissection orbit eye
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2013-04
巻	67巻
号	2号
出版者	Okayama University Medical School
開始ページ	87
終了ページ	91
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	23603924
Web of Science KeyUT	000317801700002

Multifunctional Bone Morphogenetic Protein System in Endocrinology

JaLCDOI	10.18926/AMO/49665
フルテキストURL	67_2_75.pdf
著者	Otsuka, Fumio\|
抄録	New biological activities of bone morphogenetic proteins (BMPs) in the endocrine system have recently been revealed. The BMP system is composed of approximately 30 ligands and preferential combinations of type I and type II receptors. The BMP system not only induces bone formation but also plays unique tissue-specific roles in various organs. For instance, the ovarian BMP system is a physiological inhibitor of luteinization in growing ovarian follicles. In the ovary, the expression of oocyte-derived BMP-15 is critical for female reproduction. In the pituitary, BMP-4 is a key player for initial development of the anterior pituitary, while it is also functionally involved in some differentiated pituitary tumors, including prolactinoma and Cushingʼs disease. In the adrenal glands, BMP-6 and BMP-4 modulate aldosterone and catecholamine production, respectively, which contributes to a functional interaction between the cortex and medulla. In the present review, recent advances in BMP biology in the field of endocrinology are described and the possibility for clinical application of BMP activity is discussed.
キーワード	bone morphogenetic protein folliculogenesis pituitary adenoma steroidogenesis transforming growth factor
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2013-04
巻	67巻
号	2号
出版者	Okayama University Medical School
開始ページ	75
終了ページ	86
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2013 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	23603923
Web of Science KeyUT	000317801700001

Investigation on the Biilmann's Quinhydrone Electrode. III. (Further studies on the electrode and agar bridge.)

著者	Itano, A.\| Arakawa, S.\| Hosoda, K.\|
発行日	1927-02-20
出版物タイトル	Berichte des Ohara Instituts für landwirtschaftliche Forschungen
巻	3巻
号	3号
資料タイプ	紀要論文

Table for PH Values Corresponding to Electromotive Forces determined in Quinhydrone Electrode Measurements. II.*

著者	Itano, A.\| Hosoda, K.\|
発行日	1926-08-13
出版物タイトル	Berichte des Ohara Instituts für landwirtschaftliche Forschungen
巻	3巻
号	2号
資料タイプ	紀要論文

Investigation on the Biilman's* Quinhydrone Electrode. I.

著者	Itano, A.\| Hosoda, K.\|
発行日	1926-08-13
出版物タイトル	Berichte des Ohara Instituts für landwirtschaftliche Forschungen
巻	3巻
号	2号
資料タイプ	紀要論文

Submergence as a Control Measure for the Rice-Borer, Chilo simplex Butler.

著者	Harukawa, Chukichi\|
発行日	1926-07-05
出版物タイトル	Berichte des Ohara Instituts für landwirtschaftliche Forschungen
巻	3巻
号	2号
資料タイプ	紀要論文

Morphological and Physiological Studies on a New Helminthosporium found on Leptochloa chinensis Nees.

著者	Nisikado, Yosikazu\| Miyake, Chūichi\|
発行日	1924-09-25
出版物タイトル	Berichte des Ohara Instituts für landwirtschaftliche Forschungen
巻	2巻
号	4号
資料タイプ	紀要論文

Gibberlla Saubinetii (Mont.) Sacc. as a Causal Fungus of the Wilt-disease of Horse-bean. with Plate XIV-XV.

著者	Miyake, Chuichi\|
発行日	1923-07-01
出版物タイトル	Berichte des Ohara Instituts für landwirtschaftliche Forschungen
巻	2巻
号	4号
資料タイプ	紀要論文

The Serpentine Leaf-Miner of The Peach, A Species of Lyonetia.

著者	Harukawa, Chukichi\| Yagi, Nobumasa\|
発行日	1918-12-30
出版物タイトル	Berichte des Ohara Instituts für landwirtschaftliche Forschungen
巻	1巻
号	3号
資料タイプ	紀要論文

On the Life-History and Habits of a Peach Leaf-Miner, Ornix sp.

著者	Harukawa, Chukichi\| Yagi, Nobumasa\|
発行日	1918-12-07
出版物タイトル	Berichte des Ohara Instituts für landwirtschaftliche Forschungen
巻	1巻
号	3号
資料タイプ	紀要論文

Expression of a Constitutively Active Calcineurin Encoded by an Intron-Retaining mRNA in Follicular Keratinocytes

著者	Fujimura, Atsushi\| Michiue, Hiroyuki\| Nishiki, Tei-ichi\| Ohmori, Iori\| Wei, Fanyan\| Matsui, Hideki\| Tomizawa, Kazuhito\|
発行日	2011-05-14
出版物タイトル	PLoS ONE
巻	6巻
号	3号
資料タイプ	学術雑誌論文

Serum Vaspin Concentrations Are Closely Related to Insulin Resistance, and rs77060950 at SERPINA12 Genetically Defines Distinct Group with Higher Serum Levels in Japanese Population

著者	Teshigawara, Sanae\| Wada, Jun\| Hida, Kazuyuki\| Nakatsuka, Atsuko\| Eguchi, Jun\| Murakami, Kazutoshi\| Kanzaki, Motoko\| Inoue, Kentaro\| Terami, Takahiro\| Katayama, Akihiro\| Iseda, Izumi\| Matsushita, Yuichi\| Miyatake, Nobuyuki\| McDonald, John F.\| Hotta, Kikuko\| Makino, Hirofumi\|
発行日	2012-07
出版物タイトル	Journal of Clinical Endocrinology & Metabolism
巻	97巻
号	7号
資料タイプ	学術雑誌論文

Acatalasemic mice are mildly susceptible to Acatalasemic mice are mildly susceptible to adriamycin nephropathy and exhibit increased albuminuria and glomerulosclerosis

著者	Takiue, Keiichi\| Sugiyama, Hitoshi\| Inoue, Tatsuyuki\| Morinaga, Hiroshi\| Kikumoto, Yoko\| Kitagawa, Masashi\| Kitamura, Shinji\| Maeshima, Yohei\| Wang, Dahong\| Masuoka, Noriyoshi\| Ogino, Keiki\| Makino, Hirofumi\|
発行日	2012-05-25
出版物タイトル	BMC Nephrology
巻	13巻
号	14号
資料タイプ	学術雑誌論文

Oral administration of FAK inhibitor TAE226 inhibits the progression of peritoneal dissemination of colorectal cancer

著者	Hao, Hui-fang\| Takaoka, Munenori\| Bao, Xiao-hong\| Wang, Zhi-gang\| Tomono, Yasuko\| Sakurama, Kazufumi\| Ohara, Toshiaki\| Fukazawa, Takuya\| Yamatsuji, Tomoki\| Fujiwara, Toshiyoshi\| Naomoto, Yoshio\|
発行日	2012-07-13
出版物タイトル	Biochemical and Biophysical Research Communications
巻	423巻
号	4号
資料タイプ	学術雑誌論文

COX/PGE(2) axis critically regulates effects of LPS on eosinophilia-associated cytokine production in nasal polyps

著者	Higaki, T\| Okano, M\| Fujiwara, T\| Makihara, S\| Kariya, S\| Noda, Y\| Haruna, T\| Nishizaki, K\|
発行日	2012-08
出版物タイトル	Clinical and Experimental Allergy
巻	42巻
号	8号
資料タイプ	学術雑誌論文

Liposomal Delivery of MicroRNA-7-Expressing Plasmid Overcomes Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor-Resistance in Lung Cancer Cells

著者	Rai, Kammei\| Takigawa, Nagio\| Ito, Sachio\| Kashihara, Hiromi\| Ichihara, Eiki\| Yasuda, Tatsuji\| Shimizu, Kenji\| Tanimoto, Mitsune\| Kiura, Katsuyuki\|
発行日	2011-09
出版物タイトル	Molecular Cancer Therapeutics
巻	10巻
号	9号
資料タイプ	学術雑誌論文

In vivo imaging of autophagy in a mouse stroke model

フルテキストURL	Autophagy_6_8_1107-1114.pdf
著者	Tian, FengFeng\| Deguchi, Kentaro\| Yamashita, Toru\| Ohta, Yasuyuki\| Morimoto, Nobutoshi\| Shang, Jingwei\| Zhang, Xuemei\| Liu, Ning\| Ikeda, Yoshio\| Matsuura, Tohru\| Abe, Koji\|
キーワード	autophagy apoptosis GFP-LC3 Tg mice in vivo imaging tMCAO
発行日	2010-11-16
出版物タイトル	Autophagy
巻	6巻
号	8号
開始ページ	1107
終了ページ	1114
ISSN	1554-8627
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	20930570
DOI	10.4161/auto.6.8.13427
Web of Science KeyUT	000284258900010
オフィシャル URL	http://doi.org/10.4161/auto.6.8.13427\|
関連URL	http://ousar.lib.okayama-u.ac.jp/metadata/49128

Detection of antibodies against the non-calcium-dependent epitopes of desmoglein 3 in pemphigus vulgaris and their pathogenic significance

著者	Kamiya, K\| Aoyama, Y\| Shirafuji, Y\| Hamada, T\| Morizane, S\| Fujii, K\| Hisata, K\| Iwatsuki, K\|
発行日	2012-08
出版物タイトル	British Journal of Dermatology
巻	167巻
号	2号
資料タイプ	学術雑誌論文

Therapeutic effect of suicide gene-transferred mesenchymal stem cells in a rat model of glioma

著者	Kosaka, H\| Ichikawa, T\| Kurozumi, K\| Kambara, H\| Inoue, S\| Maruo, T\| Nakamura, K\| Hamada, H\| Date, I\|
発行日	2012-08
出版物タイトル	Cancer Gene Therapy
巻	19巻
号	8号
資料タイプ	学術雑誌論文