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著者 Nishikawa, Hitoshi| Oto, Takahiro| Otani, Shinji| Harada, Masaaki| Iga, Norichika| Miyoshi, Kentaroh| Miyoshi, Shinichiro|
発行日 2013-12
出版物タイトル The Journal of Thoracic and Cardiovascular Surgery
146巻
6号
資料タイプ 学術雑誌論文
著者 Fujii, K| Kurozumi, K| Ichikawa, T| Onishi, M| Shimazu, Y| Ishida, J| Chiocca, EA| Kaur, B| Date, I|
発行日 2013-08
出版物タイトル Cancer Gene Therapy
20巻
8号
資料タイプ 学術雑誌論文
著者 Hirai, Misato| Maeda, Yukihide| Fukushima, Kunihiro| Sugaya, Akiko| Kataoka, Yuko| Nishizaki, Kazunori|
発行日 2011-09-14
出版物タイトル NeuroReport
22巻
13号
資料タイプ 学術雑誌論文
著者 Itami, Hisakazu| Tokunaga, Koji| Okuma, Yu| Hishikawa, Tomohito| Sugiu, Kenji| Ida, Kentaro| Date, Isao|
発行日 2013-09
出版物タイトル Neuroradiology
55巻
9号
資料タイプ 学術雑誌論文
著者 Yano, Shuya| Tazawa, Hiroshi| Hashimoto, Yuuri| Shirakawa, Yasuhiro| Kuroda, Shinji| Nishizaki, Masahiko| Kishimoto, Hiroyuki| Uno, Futoshi| Nagasaka, Takeshi| Urata, Yasuo| Kagawa, Shunsuke| Hoffman, Robert M.| Fujiwara, Toshiyoshi|
発行日 2013-12-01
出版物タイトル Clinical Cancer Research
19巻
23号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/52792
フルテキストURL 68_4_253.pdf
著者 Oozawa, Susumu| Sano, Shunji| Nishibori, Masahiro|
抄録 Atherosclerosis is often associated with chronic vascular inflammation. High-mobility group box 1 protein (HMGB1) plays various roles, not only as a transcriptional regulatory factor in the nucleus, but also as an inflammatory mediator. A previous study suggested that fibrinogen is an important factor associated with atherosclerosis progression. The present study was performed to examine the levels of plasma HMGB1 protein in atherosclerosis patients. We studied 24 patients with peripheral artery disease (PAD) with atherosclerosis, and 10 healthy controls. We found that the concentrations of HMGB1 were increased in the plasma of the patients with atherosclerosis, and there were significant correlations between the plasma HMGB1 and fibrinogen levels. Plasma HMGB1 may play a key role in the pathogenesis of clinical and experimental atherosclerosis.
キーワード HMGB1 fibrinogen atherosclerosis peripheral artery disease
Amo Type Erratum
出版物タイトル Acta Medica Okayama
発行日 2014-08
68巻
4号
出版者 Okayama University Medical School
開始ページ 253
終了ページ 253
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン publisher
査読 有り
Web of Science KeyUT 000340687500008
関連URL http://doi.org/10.18926/AMO/52656
JaLCDOI 10.18926/AMO/52791
フルテキストURL 68_4_249.pdf
著者 Ogawara, Yuya| Tachibana, Tomoyasu| Orita, Yorihisa| Uchino, Kaori| Wani, Yoji| Nagahiro, Itaru| Matsuyama, Yuko| Abe, Iku| Fujisawa, Masayoshi| Nishizaki, Kazunori|
抄録 We describe an extremely rare case of tracheal stenosis caused by unnoticed microscopic fiber-like foreign bodies. A 66-year-old woman complained of dyspnea with inspiratory stridor. Magnifying electroendoscopy and computed tomography revealed stenosis involving the entire circumference of the tracheal lumen. Tracheotomy and biopsy were performed. Histologically, the lesion showed chronic inflammation with a deposition of fiber-like foreign bodies. The patient had no history of trauma or inhalation injury, but had undergone intratracheal intubation on 4 occasions. The lesion was incised using semiconductor laser photoresection, and the postoperative course was good. To the best of our knowledge, this represents the first report in the English literature of tracheal stenosis caused by unnoticed foreign bodies. The origin of these fiber-like foreign bodies remains unclear but might be related to chronic inflammation resulting from intratracheal intubations.
キーワード tracheal stenosis fibrous foreign body intubation tracheotomy laser
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2014-08
68巻
4号
出版者 Okayama University Medical School
開始ページ 249
終了ページ 252
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 25145411
Web of Science KeyUT 000340687500007
JaLCDOI 10.18926/AMO/52790
フルテキストURL 68_4_243.pdf
著者 Wada, Nozomu| Yasunaka, Tetsuya| Ikeda, Fusao| Nishina, Sohji| Korenaga, Masaaki| Hino, Keisuke| Fujioka, Shin-ichi| Osawa, Toshiya| Itoshima, Tatsuya| Kawanaka, Miwa| Yamada, Gotaro| Kariyama, Kazuya| Takayama, Hiroki| Kubota, Junichi| Morimoto, Yoichi| Mizushima, Takaaki| Yamashita, Haruhiko| Tanioka, Hiroaki| Negoro, Yuji| Toshimori, Junichi| Kobashi, Haruhiko| Hirano, Atsushi| Itano, Yasuo| Takaki, Akinobu| Yamamoto, Kazuhide|
抄録 Hepatitis B virus (HBV) is one of the major viruses causing acute hepatitis. Recently, the incidence of acute hepatitis with genotype A has been increasing in Japan. The aim of this study was to investigate acute hepatitis B (AHB) in Okayama prefecture, with special attention to HBV genotype A. AHB patients who visited one of 12 general hospitals in Okayama prefecture between 2006 and 2010 were retrospectively analyzed. Over the course of the study period, 128 patients were diagnosed with AHB. Sexual transmission was supposed in the majority of patients (78 patients, 61%), including 59 (76%) having sex with heterosexual partners. The genotypes of HBV were assessed in 90 patients (70%), of whom 27 patients were infected with genotype A, 5 with genotype B, and 58 with genotype C. The prevalence of genotype A was significantly higher among male patients (28.7%), aged 20-29 (35.6%, p<0.01), among men who had sex with men (100%, p<0.005), and among patients having sex with unspecified partners (44.8%, p<0.005). Genotype A was not a significant factor associated with delayed HBsAg disappearance. Caution should be exercised with regard to sexually transmissible diseases in order to slow the pandemic spread of AHB due to genotype A.
キーワード acute hepatitis hepatitis B virus
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2014-08
68巻
4号
出版者 Okayama University Medical School
開始ページ 243
終了ページ 247
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 25145410
Web of Science KeyUT 000340687500006
JaLCDOI 10.18926/AMO/52789
フルテキストURL 68_4_235.pdf
著者 Ono, Tetsuichiro| Shikata, Kenichi| Obika, Mikako| Miyatake, Nobuyuki| Kodera, Ryo| Hirota, Daisyo| Wada, Jun| Kataoka, Hitomi| Ogawa, Daisuke| Makino, Hirofumi|
抄録 The aim of this study was to clarify the factors associated with the remission and/or regression of microalbuminuria in Japanese patients with type 2 diabetes mellitus. We retrospectively analyzed the data of 130 patients with type 2 diabetes mellitus with microalbuminuria for 2-6 years (3.39±1.31 years). Remission was defined as improving from microalbuminuria to normoalbuminuria using the albumin/creatinine ratio (ACR), and regression of microalbuminuria was defined as a decrease in ACR of 50% or more from baseline. Progression of microalbuminuria was defined as progressing from microalbuminuria to overt proteinuria during the follow-up period. Among 130 patients with type 2 diabetes mellitus with microalbuminuria, 57 and 13 patients were defined as having remission and regression, respectively, while 26 patients progressed to overt proteinuria. Sex (female), higher HDL cholesterol and lower HbA1c were determinant factors associated with remission/regression of microalbuminuria by logistic regression analysis. Lower systolic blood pressure (SBP) was also correlated with remission/regression, but not at a significant level. These results suggest that proper control of blood glucose, BP and lipid profiles may be associated with remission and/or regression of type 2 diabetes mellitus with microalbuminuria in clinical practice.
キーワード microalbuminuria type 2 diabetes mellitus remission regression
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2014-08
68巻
4号
出版者 Okayama University Medical School
開始ページ 235
終了ページ 241
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 25145409
Web of Science KeyUT 000340687500005
関連URL http://ousar.lib.okayama-u.ac.jp/metadata/52828
JaLCDOI 10.18926/AMO/52788
フルテキストURL 68_4_219.pdf
著者 Hinamoto, Norikazu| Maeshima, Yohei| Saito, Daisuke| Yamasaki, Hiroko| Tanabe, Katsuyuki| Nasu, Tatsuyo| Watatani, Hiroyuki| Ujike, Haruyo| Kinomura, Masaru| Sugiyama, Hitoshi| Sonoda, Hikaru| Kanomata, Naoki| Sato, Yasufumi| Makino, Hirofumi|
抄録 Experimental studies have demonstrated the involvement of angiogenesis-related factors in the progression of chronic kidney disease (CKD). There have so far been no reports investigating the distribution and clinical roles of Vasohibin-1 (VASH-1), a negative feedback regulator of angiogenesis, in CKD. We recruited 54 Japanese CKD patients and 6 patients who had normal renal tissues excised due to localized renal cell carcinoma. We evaluated the correlations between the renal expression level of VASH-1 and the clinical/histological parameters. VASH-1 was observed in renal endothelial/mesangial cells, crescentic lesions and interstitial inflammatory cells. Significant positive correlations were observed between 1) crescent formation and the number of VASH-1+ cells in the glomerulus (r=0.48, p=0.001) or cortex (r=0.64, p<0.0001), 2) interstitial cell infiltration and the number of VASH-1+ cells in the cortex (r=0.34, p=0.02), 3) the glomerular VEGFR-2+ area and the number of VASH-1+ cells in the glomerulus (r=0.44, p=0.01) or medulla (r=0.63, p=0.01). These results suggest that the renal levels of VASH-1 may be affected by local inflammation, crescentic lesions and VEGFR-2.
キーワード chronic kidney disease inflammation Vasohibin-1 VEGF-A VEGFR-2
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2014-08
68巻
4号
出版者 Okayama University Medical School
開始ページ 219
終了ページ 233
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 25145408
Web of Science KeyUT 000340687500004
関連URL http://ousar.lib.okayama-u.ac.jp/metadata/52824
JaLCDOI 10.18926/AMO/52787
フルテキストURL 68_4_207.pdf
著者 Yu, Liling| Kato, Yutaka| Shishido, Keisuke| Doi, Hideko| Jin, Haeng mi| Wang, Jin gang| Ikezawa, Junko| Awaya, Tsuyoshi|
抄録 This study examines the attitudes of young Japanese, Chinese, and South Koreans toward birth and child-rearing. The survey targeted four-year university students (n=1,668) who responded to an anonymous survey using self-report questionnaires between December 2012 and April 2013. The collection rates were 72.5%, 94.7%, and 96.5% for the Japanese, Chinese, and South Korean students, respectively. Correlations among the respondentsʼ attributes, medical and scientific literacy levels, and views of preferred qualities of children were analyzed using chi-square test, supplemented by residual analysis (significance level set at p<0.05). Participants were asked whether they were willing to use the following methods for obtaining preferred qualities in their children:(1) choosing a spouse (43.2%, 72.6%, and 85.1% of the Japanese, Chinese, and South Koreans, respectively, agreed);(2) using a sperm bank (cryobank) (5.8%, 60.1%, and 81.7% of the Japanese, Chines, and South Koreans, respectively, agreed);and (3) using an egg cell bank (ova bank or cryobank) (5.3%, 47.2%, and 70.3% of the Japanese, Chinese, and South Koreans, respectively, agreed). The proportion of affirmative responses (indicating “eugenic inclination”) to these statements was significantly higher among the Chinese and South Korean participants than their Japanese counterparts (p<0.001). Significant differences were also found in the attitudes of the 3 groups toward methods for obtaining the preferred qualities for their children:prenatal diagnosis, pre-implantation diagnosis, the environment during pregnancy, and child-rearing.
キーワード prenatal diagnosis pre-implantation diagnosis delivery and child-rearing eugenics healthy birth and child-rearing
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2014-08
68巻
4号
出版者 Okayama University Medical School
開始ページ 207
終了ページ 218
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 25145407
Web of Science KeyUT 000340687500003
関連URL http://ousar.lib.okayama-u.ac.jp/metadata/52823
JaLCDOI 10.18926/AMO/52786
フルテキストURL 68_4_201.pdf
著者 Endo, Hirosuke| Akazawa, Hirofumi| Mitani, Shigeru| Okada, Yoshiki| Yamane, Kentaro| Ozaki, Toshifumi|
抄録 We reviewed the treatment outcome in 14 hips of 7 patients who were diagnosed as having bilateral developmental dislocation of the hip (DDH) after walking age and could be followed up until they were at least 14 years of age. Based on the results of two-directional arthrography of the hip, closed reduction was performed in 2 hips, and open reduction was performed without osteotomy in 12 hips. The final radiographic evaluations were made according to the Kalamchi and MacEwen classification and Severin classification. The mean age at the initial visit was 1 year and 9 months (range, 1 year and 5 months to 3 years). The outcome was satisfactory for one hip in Group Ⅰ and 2 hips in Group Ⅱ according to the Kalamchi and MacEwen classification, and in 83% of the Severin Class Ⅰ and Ⅱ hips. Arthrography was useful for identifying asymmetry, demonstrating the usefulness of a treatment strategy based on arthrography of the hip.
キーワード developmental dislocation of the hip bilateral case arthrogram open reduction after walking age
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2014-08
68巻
4号
出版者 Okayama University Medical School
開始ページ 201
終了ページ 206
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 25145406
Web of Science KeyUT 000340687500002
JaLCDOI 10.18926/AMO/52785
フルテキストURL 68_4_191.pdf
著者 Shien, Kazuhiko| Yamamoto, Hiromasa| Soh, Junichi| Miyoshi, Shinichiro| Toyooka, Shinichi|
抄録 Non-small cell lung cancer (NSCLC) harboring an activating mutation within the epidermal growth factor receptor (EGFR) was defined as a clinically distinct molecular group. These lesions show oncogene addiction to EGFR and dramatic responses to the EGFR tyrosine kinase inhibitors (TKIs). Several large Phase III trials have shown that EGFR-TKIs improved the progression-free survival of patients with EGFR mutant NSCLC compared to conventional chemotherapy. However, the long-term effectiveness of EGFR-TKIs is usually limited because of acquired drug resistance. To overcome this resistance to EGFR-TKIs, it will be essential to identify the specific mechanisms underlying the resistance. Many investigators have attempted to identify the mechanisms using preclinical models and drug-resistant clinical samples. As a result, several mechanisms have been showed to be responsible for the resistance, but not all of the relevant mechanisms have been uncovered. In this review, we provide an overview of mechanisms underlying drug-resistance to EGFR-TKIs, focusing on results obtained with preclinical models, and we present some possible strategies to overcome the EGFR-TKI resistance.
キーワード non-small cell lung cancer EGFR mutation tyrosine-kinase inhibitor drug resistance cancer stem cell
Amo Type Review
出版物タイトル Acta Medica Okayama
発行日 2014-08
68巻
4号
出版者 Okayama University Medical School
開始ページ 191
終了ページ 200
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 25145405
Web of Science KeyUT 000340687500001
著者 Hayakawa, Hiromi| Ichihara, Eiki| Ohashi, Kadoaki| Ninomiya, Takashi| Yasugi, Masayuki| Takata, Saburo| Sakai, Katsuya| Matsumoto, Kunio| Takigawa, Nagio| Tanimoto, Mitsune| Kiura, Katsuyuki|
発行日 2013-11
出版物タイトル Cancer Science
104巻
11号
資料タイプ 学術雑誌論文
著者 Kurahashi, Hiroaki| Watanabe, Masami| Sugimoto, Morito| Ariyoshi, Yuichi| Mahmood, Sabina| Araki, Motoo| Ishii, Kazushi| Nasu, Yasutomo| Nagai, Atsushi| Kumon, Hiromi|
発行日 2013-12
出版物タイトル Endocrine Journal
60巻
12号
資料タイプ 学術雑誌論文
著者 Hayashi, Tatsuro| Asano, Hiroaki| Toyooka, Shinichi| Tsukuda, Kazunori| Soh, Junichi| Shien, Tadahiko| Taira, Naruto| Maki, Yuho| Tanaka, Norimitsu| Doihara, Hiroyoshi| Nasu, Yasutomo| Huh, Nam-ho| Miyoshi, Shinichiro|
発行日 2012-05
出版物タイトル Journal of Cancer Research and Clinical Oncology
138巻
5号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/bgeou/52779
タイトル(別表記) The Effects of Friendship Relationships of the Aged upon their Subjective Well-being: The Case of Participants in a College for the Elderly in a Small City in Japan (Part Ⅰ)
フルテキストURL bgeou_156_039_048.pdf
著者 野邊 政雄| 大須賀 翼|
抄録  本稿の目的は,高齢者が取り結んでいる友人関係のどのような側面が主観的幸福感に影響 を及ぼすかを明らかにすることである。地方小都市である香川県さぬき市で老人大学の受講 生を対象にサーベイ調査を2012 年に実施した。この調査データの分析によって,次の2点 を明らかにした。(1)サポートの授受を伴う友人関係ではなく,交遊する友人関係が高齢者 の主観的幸福感に影響を及ぼしていた。そして,交遊する友人関係を多く取り結んでいる高 齢者ほど,高い主観的幸福感をもっていた。(2)交遊する友人関係のなかでは,年賀状の交 換をする友人関係,お茶を飲んだり食事をしたりする友人関係が高齢者の主観的幸福感に影 響を及ぼしていた。そして,年賀状の交換をする友人関係,お茶を飲んだり食事をしたりす る友人関係を多く取り結んでいる高齢者ほど,高い主観的幸福感をもっていた。
キーワード 香川県さぬき市 高齢者 友人関係 主観的幸福感 老人大学
出版物タイトル 岡山大学大学院教育学研究科研究集録
発行日 2014-07-28
156巻
開始ページ 39
終了ページ 48
ISSN 1883-2423
言語 日本語
論文のバージョン publisher
NAID 120005464807
JaLCDOI 10.18926/bgeou/52778
フルテキストURL bgeou_156_033_038.pdf
著者 Seta, Yukito| Jiang, Fan|
抄録 The present study addresses the question how Go for it!, a textbook developed on task-based language instruction mode, treats language forms. Tasks and activities from a sample unit in Go for it! are analyzed to examine whether and how textbook writers incorporate a Focus on Form in the task and activity design. The results show that equal emphasis is laid on both meaning and form, and three major types of Focus on Form tasks and two types of Focus on Form activities are identified. The study may contribute to textbook designers and teachers in treating the issue of how to design Focus on Form activities in task-based language teaching.
キーワード meaning form focus on form task-based teaching
出版物タイトル 岡山大学大学院教育学研究科研究集録
発行日 2014-07-28
156巻
開始ページ 33
終了ページ 38
ISSN 1883-2423
言語 英語
論文のバージョン publisher
NAID 120005464806
JaLCDOI 10.18926/bgeou/52777
タイトル(別表記) Developing the Outline of a Document Explaining the Necessity of Effective Educational Goals to Private Kindergartens’ Staff Members
フルテキストURL bgeou_156_023_031.pdf
著者 横松 友義|
抄録  わが国の幼稚園教育において,カリキュラムマネジメントをさらに発展させていくために は,幼稚園現場の職員に対する,実効のある保育目標明確化の必要性が理解できる説明資料 を開発することが不可欠であるといえる。そこで,本研究では,その最初の段階として,私 立幼稚園職員を対象に,その過半数にそのことが理解できる説明資料の概要をアクション・ リサーチにより開発している。その概要に含まれる項目は,各幼稚園において実効のある保 育目標明確化の必要性が生じた政策的背景,幼稚園の保育目標にかかわる法的規定,これま でに開発されている実効のある保育目標の明確化手順,保護者が実効のある保育目標を共有 することによって保育についての共通理解と子育てへの意欲が促される可能性,保育者が実 効のある保育目標を共有することによって保育についての共通理解と意欲とが促される可能 性である。
キーワード 私立幼稚園職員 実効のある保育目標明確化 必要性 説明 資料
出版物タイトル 岡山大学大学院教育学研究科研究集録
発行日 2014-07-28
156巻
開始ページ 23
終了ページ 31
ISSN 1883-2423
言語 日本語
論文のバージョン publisher
NAID 120005464805
JaLCDOI 10.18926/bgeou/52776
タイトル(別表記) Analyzing Peer Interactions and Teachers’ Support During Structured Play Activities in a Special Needs Education School.
フルテキストURL bgeou_156_015_021.pdf
著者 仲矢 明孝| 中尾 果歩| 竹内 愛|
抄録  知的障害特別支援学校小学部の「遊びの指導」の授業における児童同士のかかわりの実態 を整理し,かかわりを促す教師の具体的な支援の在り方について検討するため,実際の授業 における児童及び教師の言動を時間の流れに沿って書き出して作成したトランスクリプトを 基に整理・分析した。その結果,実態の異なる2人の対象児は共に,他の児童に対して高い 関心を示しており,その示し方は発声・発語や身体動作に比べ,注視が多かったことが確か められた。また,対象児の他の児童に対する発信の契機を調べた結果,教師よりも他の児童 の言動が契機となった場合が多く,教師が契機であった場合については,対象児の他の児童 への発信に至る過程が4パターンに分類された。さらに,児童同士のかかわりを促す教師の 具体的な支援の在り方に関する示唆を得た。
キーワード 知的障害特別支援学校 遊びの指導 授業分析 児童同士のかかわり 発信の過程
出版物タイトル 岡山大学大学院教育学研究科研究集録
発行日 2014-07-28
156巻
開始ページ 15
終了ページ 21
ISSN 1883-2423
言語 日本語
論文のバージョン publisher
NAID 120005464804