検索結果 - 岡山大学学術成果リポジトリ

With regard to our manuscripts on the commercial saliva substitute, Oralbalance®--its formula has been changed

フルテキストURL	Support_care_cancer_22_12_3121.pdf
著者	Sugiura, Yuko\| Soga, Yoshihiko\| Tanimoto, Ichiro\| Kokeguchi, Susumu\| Morishige-Nishide, Sachiko\| Itami-Kono, Kotoe\| Takahashi, Kanayo\| Fujii, Nobuharu\| Ishimaru, Fumihiko\| Tanimoto, Mitsune\| Yamabe, Kokoro\| Tsutani, Soichiro\| Nishimura, Fusanori\| Takashiba, Shogo\|
発行日	2014-12
出版物タイトル	Supportive Care in Cancer
巻	22巻
号	12号
出版者	Springer
開始ページ	3121
終了ページ	3122
ISSN	0941-4355
NCID	AA10996793
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	25239598
DOI	10.1007/s00520-014-2432-8
Web of Science KeyUT	000344644100001
関連URL	isVersionOf https://doi.org/10.1007/s00520-014-2432-8

Prevalence of oral health-related conditions that could trigger accidents for patients with moderate-to-severe dementia

フルテキストURL	Gerodontology_34_1_129.pdf
著者	Kobayashi, Naoki\| Soga, Yoshihiko\| Maekawa, Kyoko\| Kanda, Yuko\| Kobayashi, Eiko\| Inoue, Hisako\| Kanao, Ayana\| Himuro, Yumiko\| Fujiwara, Yumi\|
キーワード	dementia hospital care mouth risk management
備考	This is an Accepted Manuscript of an article published by John Wiley\|
発行日	2017-03
出版物タイトル	Gerodontology
巻	34巻
号	1号
出版者	John Wiley
開始ページ	129
終了ページ	134
ISSN	0734-0664
NCID	AA10450927
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	27207609
DOI	10.1111/ger.12235
Web of Science KeyUT	000394951200016
関連URL	isVersionOf https://doi.org/10.1111/ger.12235

日本古代地域史研究の新視点 : 空間分析と生態学的アプローチ

タイトル（別表記）	Spatial Analysis and Ecological Approach to Local Society in Ancient Japan
フルテキストURL	786_63_74_2015.pdf
著者	今津勝紀\|
備考	本研究は、「空間解析を通じた日本古代地域社会の研究」（基盤研究（C）研究代表者　岡山大学・社会文化科学研究科・教授･今津勝紀　課題番号15K02833）の成果である。\|
発行日	2015-10
出版物タイトル	歴史評論
号	786号
出版者	歴史科学協議会
開始ページ	63
終了ページ	74
ISSN	0386-8907
NCID	AN00255224
資料タイプ	学術雑誌論文
言語	日本語
OAI-PMH Set	岡山大学
論文のバージョン	author
NAID	40020584694
オフィシャル URL	http://www.maroon.dti.ne.jp/rekikakyo/magazine/contents/kakonomokuji/786.html\|

An Open-label Single-arm Trial of a Novel Extramedullary Guide Coordinated with 3D Surgical Assistive Software for Total Knee Arthroplasty

JaLCDOI	10.18926/AMO/56186
フルテキストURL	72_4_441.pdf
著者	Kida, Daihei\| Hashimoto, Hiroya\| Saito, Akiko M.\| Kito, Yukari\| Mori, Kouichi\| Terabe, Kenya\| Takahashi, Nobunori\| Tomita, Yasushi\|
抄録	There is no assistive device for extramedullary surgery coordinated with 3D surgical assistive software for the total knee arthroplasty (TKA). We developed a novel extramedullary universal guide coordinated with 3D surgical assistive software and a novel extramedullary patient-specific assistive guide for the placement of femoral components by referring to an area not affected by cartilage or bone spurs, and filed a patent application. In this study, we visualize and reconstruct the total alignment of the lower extremity in TKA using these surgical devices, and validate their precision. A report releasing study results will be submitted in an appropriate journal.
キーワード	total knee arthroplasty 3D surgical assistive software tibia femur extramedullary guide
Amo Type	Clinical Study Protocol
出版物タイトル	Acta Medica Okayama
発行日	2018-08
巻	72巻
号	4号
出版者	Okayama University Medical School
開始ページ	441
終了ページ	445
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30140096

The Effect of Interim FDG-PET-guided Response-Adapted Therapy in Pediatric Patients with Hodgkin’s Lymphoma (HL-14) : Protocol for a Phase II Study

JaLCDOI	10.18926/AMO/56185
フルテキストURL	72_4_437.pdf
著者	Koga, Yuhki\| Baba, Shingo\| Fukano, Reiji\| Nakamura, Katsumasa\| Soejima, Toshinori\| Maeda, Naoko\| Sunami, Shosuke\| Ueyama, Junichi\| Mitsui, Tetsuo\| Mori, Takeshi\| Osumi, Tomoo\| Sekimizu, Masahiro\| Ohki, Kentaro\| Tanaka, Fumiko\| Kamei, Michi\| Fujita, Naoto\| Mori, Tetsuya\| Saito, Akiko M.\| Kada, Akiko\| Kobayashi, Ryoji\|
抄録	This trial enrolls patients with untreated Hodgkin’s lymphoma aged<20 years at diagnosis and examines the effects of omitting radiation therapy if the FDG-positron emission tomography (PET) findings after two completed cycles of combination chemotherapy are negative. It thereby aims to determine whether patients who truly require radiation therapy can be identified by FDG-PET. If so, this modality could be used to omit radiation therapy for all other patients, decreasing the risk of serious long-term complications without affecting survival rates. The outcomes of patients for whom FDG-PET is used to assess early treatment response will also be determined.
キーワード	Hodgkin’s lymphoma pediatric fludeoxyglucose positron emission tomography
Amo Type	Clinical Study Protocol
出版物タイトル	Acta Medica Okayama
発行日	2018-08
巻	72巻
号	4号
出版者	Okayama University Medical School
開始ページ	437
終了ページ	440
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30140095

A Phase I/II Study of Crizotinib for Recurrent or Refractory Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma and a Phase I Study of Crizotinib for Recurrent or Refractory Neuroblastoma : Study Protocol for a Multicenter Single-arm Open-label Trial

JaLCDOI	10.18926/AMO/56184
フルテキストURL	72_4_431.pdf
著者	Sekimizu, Masahiro\| Osumi, Tomoo\| Fukano, Reiji\| Koga, Yuhki\| Kada, Akiko\| Saito, Akiko M.\| Mori, Tetsuya\|
抄録	Crizotinib is an inhibitor of multiple tyrosine kinases, including the anaplastic lymphoma kinase (ALK). Responses to crizotinib have also been reported in patients with ALK-positive anaplastic large-cell lymphoma (ALCL) and solid tumors with ALK-mutation, including neuroblastoma. Optimal treatment for patients with recurrent or refractory ALK-positive ALCL and neuroblastoma has not been established. There is a need to develop new drugs for these patients. The objectives of this trial are to evaluate the tolerability and safety of crizotinib in Japanese patients with recurrent/refractory ALK-positive ALCL or neuroblastoma (phase I) and its efficacy in recurrent/refractory ALK-positive ALCL (phase II).
キーワード	crizotinib recurrent refractory anaplastic large cell lymphoma neuroblastoma
Amo Type	Clinical Study Protocol
出版物タイトル	Acta Medica Okayama
発行日	2018-08
巻	72巻
号	4号
出版者	Okayama University Medical School
開始ページ	431
終了ページ	436
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30140094

Phase II Clinical Trial for Newly Diagnosed Children and Adolescents with Localized Lymphoblastic Lymphoma (Japanese Leukemia/Lymphoma Study Group Trial LLB-NHL03) : Study Protocol for Nationwide Multicenter Trial

JaLCDOI	10.18926/AMO/56183
フルテキストURL	72_4_427.pdf
著者	Sekimizu, Masahiro\| Fujimoto, Junichiro\| Takimoto, Tetsuya\| Tsurusawa, Masahito\| Horibe, Keizo\| Sunami, Shosuke\|
抄録	Pediatric patients with lymphoblastic lymphoma are generally treated using the Berlin-Frankfurt-Munster (BFM) 90 protocol, which is the standard treatment strategy for pediatric acute lymphoblastic leukemia, and have a favorable outcome. However, this intense regimen includes high total doses of anthracycline and alkylating agents, and is known to cause late complications. We therefore planned a clinical trial to examine the efficacy and safety of a modified BFM regimen. We expect that this phase II, nationwide multicenter trial will help to establish an effective and safer standard therapy for stage I/II pediatric lymphoblastic lymphoma.
キーワード	pediatrics limited stage lymphoblastic lymphoma efficacy safety
Amo Type	Clinical Study Protocol
出版物タイトル	Acta Medica Okayama
発行日	2018-08
巻	72巻
号	4号
出版者	Okayama University Medical School
開始ページ	427
終了ページ	430
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30140093

Study Design of a Phase II Clinical Trial to Assess the Efficacy and Safety of Eperisone in Japanese Type 2 Diabetes Patients with Risk and Non-risk Alleles of CDKAL1

JaLCDOI	10.18926/AMO/56182
フルテキストURL	72_4_423.pdf
著者	Sakakida, Kourin\| Wei, Fan-Yan\| Senokuchi, Takafumi\| Shimoda, Seiya\| Kakuma, Tatsuyuki\| Araki, Eiichi\| Tomizawa, Kazuhito\| The Eperisone for Diabetes with Impaired tRNA (EDIT) Study Group\|
抄録	Genetic variation in Cdk5 Regulatory Associated Protein 1-Like 1 (CDKAL1) is associated with the development of type 2 diabetes (T2D). Dysfunction of CDKAL1 impairs the translation of proinsulin, which leads to glucose intolerance. Eperisone, an antispasmodic agent, has been shown to ameliorate glucose intolerance in Cdkal1-deficient mice. We have launched a phase II clinical study to investigate the potential anti-diabetic effect of eperisone in T2D patients carrying risk or non-risk alleles of CDKAL1. The primary endpoint is the change of hemoglobin A1c (HbA1c) levels. We also examined whether the efficacy of eperisone in T2D patients is associated with CDKAL1 activity.
キーワード	diabetes insulin secretion single nucleotide polymorphism glucose
Amo Type	Clinical Study Protocol
出版物タイトル	Acta Medica Okayama
発行日	2018-08
巻	72巻
号	4号
出版者	Okayama University Medical School
開始ページ	423
終了ページ	426
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30140092

Microseizures Induced by Topiramate

JaLCDOI	10.18926/AMO/56181
フルテキストURL	72_4_419.pdf
著者	Miyake, Susumu\| Sugita, Makio\| Okazaki, Tomio\| Takenaka, Mieko\| Kuwabara, Kentarou\| Ogawa, Kazunori\|
抄録	A 22-year-old Japanese male with trisomy 21 was diagnosed with West syndrome at 4 months old. After the suppression of epileptic spasms using adrenocorticotropic hormone therapy, he had complex partial seizures and bilateral frontal epileptic discharges on EEG. Although the introduction of topiramate (TPM) decreased the seizures during wakefulness, frequent episodes of brief eye-opening appeared during sleep while the patient was taking TPM (400 mg/day). EEG showed fast activity at the times of eye-opening. The episodes of eye-opening during sleep and the fast activities disappeared upon TPM discontinuation. This is the first report of TPM-induced microseizures similar to benzodiazepine-induced microseizures.
キーワード	topiramate microseizures paroxysmal fast activity side effects seizure aggravation
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2018-08
巻	72巻
号	4号
出版者	Okayama University Medical School
開始ページ	419
終了ページ	422
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30140091

Development of Gait Rehabilitation System Capable of Assisting Pelvic Movement of Normal Walking

JaLCDOI	10.18926/AMO/56180
フルテキストURL	72_4_407.pdf
著者	Jung, Chanyul\| Jung, Suhun\| Chun, Min Ho\| Lee, Jong Min\| Park, Shinsuk\| Kim, Seung-Jong\|
抄録	Gait rehabilitation training with robotic exoskeleton is drawing attention as a method for more advanced gait rehabilitation training. However, most of the rehabilitation robots are mainly focused on locomotion training in the sagittal plane. This study introduces a novel gait rehabilitation system with actuated pelvic motion to generate natural gait motion. The rehabilitation robot developed in this study, COWALK, is a lower-body exoskeleton system with 15 degrees of freedom (DoFs). The COWALK can generate multi-DoF pelvic movement along with leg movements. To produce natural gait patterns, the actuation of pelvic movement is essential. In the COWALK, the pelvic movement mechanism is designed to help hemiplegic patients regain gait balance during gait training. To verify the effectiveness of the developed system, the gait patterns with and without pelvic movement were compared to the normal gait on a treadmill. The experimental results show that the active control of pelvic movement combined with the active control of leg movement can make the gait pattern much more natural.
キーワード	exoskeleton gait rehabilitation balance control pelvic movement gravity compensation
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2018-08
巻	72巻
号	4号
出版者	Okayama University Medical School
開始ページ	407
終了ページ	417
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30140090

Mixed HCV Infection of Genotype 1B and Other Genotypes Influences Non-response during Daclatasvir + Asunaprevir Combination Therapy

JaLCDOI	10.18926/AMO/56178
フルテキストURL	72_4_401.pdf
著者	Wada, Nozomu\| Ikeda, Fusao\| Mori, Chizuru\| Takaguchi, Koichi\| Fujioka, Shin-ichi\| Kobashi, Haruhiko\| Morimoto, Yoichi\| Kariyama, Kazuya\| Sakaguchi, Kosaku\| Hashimoto, Noriaki\| Moriya, Akio\| Kawaguchi, Mitsuhiko\| Miyatake, Hirokazu\| Hagihara, Hiroaki\| Kubota, Junichi\| Takayama, Hiroki\| Takeuchi, Yasuto\| Yasunaka, Tetsuya\| Takaki, Akinobu\| Iwasaki, Yoshiaki\| Okada, Hiroyuki\|
抄録	Daclatasvir (DCV) + asunaprevir (ASV) combination therapy has become available for patients with hepatitis C virus (HCV) serogroup 1 infection. We studied the efficacy of this therapy by focusing on the factors associated with sustained virological responses (SVR) including resistance-associated variants (RAVs) and mixed infection of different HCV genotypes. We enrolled 951 HCV serogroup 1-positive patients who received this combination therapy at our hospital or affiliated hospitals. The presence of RAVs in non-structural (NS) regions 3 and 5A was analyzed by direct sequencing. HCV genotypes were determined by PCR with genotype-specific primers targeting HCV core and NS5B regions. SVR was achieved in 91.1% of patients. Female sex, age > 70 years, and RAVs were significantly associated with non-SVR (p<0.01 for all). Propensity score-matching results among the patients without RAVs regarding sex, age, and fibrosis revealed that mixed HCV infection determined by HCV NS5B genotyping showed significantly lower SVR rates than 1B-mono infection (p=0.02). Female sex and RAVs were significant factors associated with treatment failure of this combination therapy for patients with HCV serogroup 1 infection. Mixed HCV infection other than 1B-mono infection would be useful for predicting treatment failure.
キーワード	mixed genotype daclatasvir asunaprevir HCV serogrouping 1 infection
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2018-08
巻	72巻
号	4号
出版者	Okayama University Medical School
開始ページ	401
終了ページ	406
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30140089

Relationship between Sedentary Behavior and Health-Related Quality of Life in Patients on Chronic Hemodialysis

JaLCDOI	10.18926/AMO/56177
フルテキストURL	72_4_395.pdf
著者	Hishii, Shuhei\| Miyatake, Nobuyuki\| Nishi, Hiroyuki\| Katayama, Akihiko\| Ujike, Kazuhiro\| Koumoto, Kiichi\| Hashimoto, Hiroo\|
抄録	We explored the relationship between sedentary behavior and the health-related quality of life (HRQOL) in patients on chronic hemodialysis. A total of 60 outpatients, aged 71.1±12.0 years, were enrolled in this cross-sectional study. Sedentary behavior was measured using a tri-accelerometer and HRQOL was evaluated by the Euro-QOL questionnaire (EQ-5D). The relationship between the patients’ sedentary behavior and HRQOL was evaluated by simple and multiple correlation analyses. The relative sedentary behavior (%) for total days was 73.7±12.9% and the EQ-5D scores were 0.688±0.233. Relative sedentary behavior (%) was negatively correlated with EQ-5D scores for total days, hemodialysis days and non-hemodialysis days. The relative light-intensity physical activity (LPA) (%) and relative moderately vigorous-intensity physical activity (MVPA) (%) were correlated with EQ-5D scores. Multiple regression showed that the relative sedentary behavior (%) had a clinical impact on EQ-5D scores after adjusting for confounding factors for total, hemodialysis and non-hemodialysis days. Sedentary behavior is closely linked to HRQOL, and reducing sedentary behavior may be beneficial to improve the HRQOL of patients on chronic hemodialysis.
キーワード	physical activity sedentary behavior health-related quality of life HRQOL hemodialysis
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2018-08
巻	72巻
号	4号
出版者	Okayama University Medical School
開始ページ	395
終了ページ	400
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30140088

Women with Recurrent Pregnancy Loss : Their Psychology During Late Pregnancy and the Supportive Behavior of Their Partners

JaLCDOI	10.18926/AMO/56176
フルテキストURL	72_4_387.pdf
著者	Hada, Kumiko\| Kuse, Emiko\| Nakatsuka, Mikiya\|
抄録	To elucidate the psychiatric characteristics of mothers and the supportive behavior of their partners during late pregnancy, 131 mothers who gave birth at 2 general hospitals in City A between August 2009 and September 2010 (control group: n=90; recurrent pregnancy loss (RPL) group: n=41) completed a self-administered questionnaire on four separate occasions: during late pregnancy, during hospitalization, at 1-month postpartum, and at 3-months postpartum. The RPL group had significantly (p=0.03) lower anxiety regarding potential change in their appearance than the controls, but were more likely to worry about losing their baby (58% vs. 38%) (p=0.021). At 3-months postpartum, the RPL group reported having had more stress during pregnancy than the controls (49% vs. 31%; p=0.041). There were no significant differences in state or trait anxiety (State-Trait Anxiety Inventory) between the 2 groups at any of the four measurements. However, state anxiety decreased significantly throughout the hospitalization for controls (p <0.001), but did not decrease significantly for the RPL group until 3 months postpartum (p<0.05). RPL participants who expressed high satisfaction with their partners’ supportive behavior received significantly greater psychological support than did participants with low satisfaction. Healthcare professionals should attempt to support both members of RPL couples.
キーワード	recurrent pregnancy loss persistent anxiety supportive behavior of partner psychological support
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2018-08
巻	72巻
号	4号
出版者	Okayama University Medical School
開始ページ	387
終了ページ	394
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30140087

Impact of Polyp Regression on 2-year Outcomes of Intravitreal Aflibercept Injections: A Treat-and-Extend Regimen for Polypoidal Choroidal Vasculopathy

JaLCDOI	10.18926/AMO/56175
フルテキストURL	72_4_379.pdf
著者	Morizane-Hosokawa, Mio\| Morizane, Yuki\| Kimura, Shuhei\| Shiode, Yusuke\| Hirano, Masayuki\| Doi, Shinichiro\| Toshima, Shinji\| Hosogi, Mika\| Fujiwara, Atsushi\| Shiraga, Fumio\|
抄録	We conducted intravitreal aflibercept injections (IVAs) for 37 Japanese patients (28 males, 9 females, mean age 73.4 years) with polypoidal choroidal vasculopathy (PCV), with a treat-and-extend regimen (TER). We evaluated the impact of polyp regression after a loading dose (2-mg IVA 1×/month for 3 months) on the patients' 2-year treatment outcomes. Thirty-seven eyes were treated with IVA by a TER for 2 years. We divided the patients into 2 groups based on their polyp status after the loading dose: polyp regression (PR+) (n=19) and no polyp regression (PR−) (n=18). We compared the groups’ best-corrected visual acuity (BCVA), central retinal thickness (CRT), recurrence rate, total number of injections, and final treatment interval. Both the BCVA and CRT were significantly improved by the treatment in both groups, with no between-group difference in the amount of change (p=0.769). In the polyp regression (+) group, recurrence was significantly less common (p=0.03), the mean total number of injections was significantly lower (p=0.013), and the mean treatment interval was significantly longer (0.042). Regarding the 2-year outcomes for PCV, the eyes with post-loading-dose polyp regression demonstrated less frequent recurrence and required fewer numbers of injections compared to the eyes without polyp regression.
キーワード	polypoidal choroidal vasculopathy aflibercept treat-and-extend regimen polyp regression
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2018-08
巻	72巻
号	4号
出版者	Okayama University Medical School
開始ページ	379
終了ページ	385
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30140086

Venous Thromboembolism in Patients with Acute Thoracolumbar Spinal Cord Injury

JaLCDOI	10.18926/AMO/56173
フルテキストURL	72_4_375.pdf
著者	Morita, Takuya\| Sugimoto, Yoshihisa\| Takigawa, Tomoyuki\| Misawa, Haruo\| Ito, Yasuo\| Ozaki, Toshifumi\|
抄録	Venous thromboembolism (VTE) is a major complication in patients with acute spinal cord injury. There are few reports of VTE with acute thoracolumbar spinal cord injury (TLSCI). We assessed the incidence of VTE with acute TLSCI using color Doppler ultrasonography. We retrospectively assessed 75 patients with acute TLSCI (T1 to L1). All patients were surgically treated. VTE of the lower extremity and pelvis was assessed using color Doppler ultrasound regardless of whether symptoms were present. This retrospective study included patients who were assessed between 6 and 10 days (mean 8.1 days) after injury. VTE was detected in 27 of the 75 patients (35.7%) with or without paralysis. Of the 13 patients who had complete motor paralysis, 8 (62%) had VTE; of the 31 patients with incomplete motor paralysis, 10 (32%) had VTE, and of the 31 patients without motor paralysis, 9 (29%) had VTE. Among the patients with TLSCI, those with VTE had a significantly higher mean age than those without. The incidence of VTE in TLSCI patients is not related to the severity of paralysis in a Japanese population. The incidence appears to be related primarily to age.
キーワード	venous thromboembolism thoracolumbar spinal cord injury paralysis, trauma complication
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2018-08
巻	72巻
号	4号
出版者	Okayama University Medical School
開始ページ	375
終了ページ	378
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30140085

Hormonal Therapy Resistant Estrogen-receptor Positive Metastatic Breast Cancer Cohort (HORSE-BC) Study : Current Status of Treatment Selection in Japan

JaLCDOI	10.18926/AMO/56172
フルテキストURL	72_4_369.pdf
著者	Iwamoto, Takayuki\| Taira, Naruto\| Fujisawa, Tomomi\| Araki, Kazuhiro\| Sakamaki, Kentaro\| Sangai, Takafumi\| Kikawa, Yuichiro\| Shien, Tadahiko\| Takao, Shintaro\| Sato, Masako\| Goto, Yoshinari\| Yoshida, Takashi\| Takahashi, Masato\| Aihara, Tomohiko\| Mukai, Hirofumi\|
抄録	The Hormonal therapy resistant estrogen-receptor positive metastatic breast cancer cohort (HORSE-BC) study is a multicenter observational study evaluating the efficacy and safety of secondary endocrine therapy (ET) for postmenopausal cases of metastatic breast cancer (MBC) with poor response to primary ET. In this initial report we analyze the HORSE-BC baseline data to clarify the current status of treatment selection for MBC in Japan. Baseline data for the 50 patients enrolled in HORSE-BC were analyzed, including patient characteristics, types of secondary ET, and reasons for selecting secondary ET. Postoperative recurrence was detected in 84% of patients (42/50) and de novo stage IV breast cancer in 16% (8/50). Forty-one patients (41/50; 82%) received fulvestrant, 5 patients (10%) received selective estrogen receptor modulators (SERMs), 3 patients (6%) received ET plus a mammalian target of rapamycin (mTOR) inhibitor, and 1 patient received an aromatase inhibitor (AI) as the secondary ET. Forty-five patients selected their secondary ET based on its therapeutic effect, while 14 patients selected it based on side effects. Most patients with progression after primary ET selected fulvestrant as the secondary ET based on its therapeutic and side effects. We await the final results from the HORSE-BC study.
キーワード	breast cancer secondary endocrine therapy low sensitivity primary endocrine therapy fulvestrant
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2018-08
巻	72巻
号	4号
出版者	Okayama University Medical School
開始ページ	369
終了ページ	374
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30140084

Upregulation of Angiogenic Factors via Protein Kinase C and Hypoxia-induced Factor-1α Pathways under High-glucose Conditions in the Placenta

JaLCDOI	10.18926/AMO/56171
フルテキストURL	72_4_359.pdf
著者	Mitsui, Takashi\| Tani, Kazumasa\| Maki, Jota\| Eguchi, Takeshi\| Tamada, Shoko\| Eto, Eriko\| Hayata, Kei\| Masuyama, Hisashi\|
抄録	Abnormal glucose metabolism during pregnancy is an established risk factor for preeclampsia (PE). Disruption of the balance between placental angiogenic factors is linked to PE pathophysiology. We examined whether hypoxia-induced factor-1α (HIF-1α) and protein kinase Cβ (PKCβ) are involved in the regulation of placental angiogenic factors under high-glucose conditions in vitro. The human choriocarcinoma cell lines BeWo and JEG-3, and the human trophoblast cell line HTR-8/SVneo were cultured with 10 and 25 mmol/L glucose [control glucose group (CG) and high-glucose group (HG), respectively]. We examined the changes in HIF-1α, soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), and vascular endothelial growth factor (VEGF) expression in the CG and HG by real-time PCR and ELISA. PKC activation was also measured by ELISA. The expressions of HIF-1α, sFlt-1, PlGF, and VEGF were significantly higher in the HG than in the CG. PKC activity was significantly increased in the HG. High glucose affected the expression of angiogenic factors in choriocarcinoma cells via the PKCβ and HIF-1α pathways, suggesting their involvement in PE pathogenesis.
キーワード	high-glucose condition preeclampsia protein kinase C
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2018-08
巻	72巻
号	4号
出版者	Okayama University Medical School
開始ページ	359
終了ページ	367
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30140083

Epidemiology of Pediatric Acute Encephalitis/Encephalopathy in Japan

JaLCDOI	10.18926/AMO/56170
フルテキストURL	72_4_351.pdf
著者	Goto, Shinichiro\| Nosaka, Nobuyuki\| Yorifuji, Takashi\| Wada, Tomoaki\| Fujii, Yosuke\| Yashiro, Masato\| Washio, Yosuke\| Hasegawa, Kosei\| Tsukahara, Hirokazu\| Morishima, Tsuneo\|
抄録	We studied the etiology of pediatric acute encephalitis/encephalopathy (pAEE) using epidemiological data obtained from a nationwide survey in Japan. Two-step questionnaires were sent to the pediatric departments of hospitals throughout the country in 2007, querying the number of the cases during 2005-2006 as the first step, and asking for the details of clinical information as the second step. In all, 636 children with pAEE (age ≤ 15 years) were enrolled. For the known etiology of pAEE (63.5% of the total cases), 26 microbes and 2 clinical entities were listed, but the etiology of 36.5% remained unknown. Influenza virus (26.7%), exanthem subitum (12.3%), and rotavirus (4.1%) were the most common, and the incidence of pAEE peaked at the age of 1 year. This trend was common among all etiologies. Among the neurological symptoms observed at the onset of pAEE, seizures were observed more often in patients aged ≤ 3 years, although abnormal speech and behavior were also common in older children. Undesirable outcomes (death and neurological sequelae) occurred at high rates in patients with any known etiology other than mycoplasma. In conclusion, these findings provide comprehensive insight into pAEE in Japan.
キーワード	childhood encephalitis encephalopathy etiology Japan pAEE
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2018-08
巻	72巻
号	4号
出版者	Okayama University Medical School
開始ページ	351
終了ページ	357
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30140082

A Multidisciplinary Approach to the Management of Chronic Pain through a Self-managed Behavioral Exercise Program : A Pilot Study in Japan

JaLCDOI	10.18926/AMO/56169
フルテキストURL	72_4_343.pdf
著者	Nishie, Hiroyuki\| Tetsunaga, Tomoko\| Kanzaki, Hirotaka\| Oda, Koji\| Inoue, Shinichiro\| Ryuo, Yuta\| Ota, Haruyuki\| Miyawaki, Takuya\| Arakawa, Kyosuke\| Tetsunaga, Tomonori\| Kitamura, Yoshihisa\| Sendo, Toshiaki\| Morimatsu, Hiroshi\| Ozaki, Toshifumi\| Nishida, Keiichiro\|
抄録	We conducted this study to determine the short-term treatment outcomes of multidisciplinary approaches to chronic pain management for outpatients in Japan. We evaluated pain reduction and improvement in quality of life (QOL) after treatment. We analyzed 32 patients who had experienced intractable chronic pain for > 3 months. The patients received multidisciplinary therapeutic self-managed exercise instructions and then underwent evaluations 1 and 3 months after the treatment. We used the Pain Disability Short Form-36 (SF-36), Pain Catastrophizing Scale (PCS), and Pain Disability Assessment Scale (PDAS) to evaluate QOL. Although the pain levels were the same before and after the physical exercise program, the patients showed significant improvements in physical function on the SF-36 (48.5 vs. 54.5, 3 months vs. 1 month; p=0.0124), the magnification subscale on the PCS (6.8 vs. 5.9, 1 month vs. before; p=0.0164) and the PDAS (29.2 vs. 23.4, 3 months vs. before; p=0.0055). Chronic pain should be treated with a biopsychosocial approach, but time constraints and costs have limited the implementation of multidisciplinary and behavioral approaches to chronic pain management. Our findings demonstrate that clinical improvements are possible for patients with chronic pain, using multidisciplinary team resources widely available in Japanese clinical practice.
キーワード	multidisciplinary treatment pain management quality of life biopsychosocial approach chronic pain
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2018-08
巻	72巻
号	4号
出版者	Okayama University Medical School
開始ページ	343
終了ページ	350
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30140081

Relationship between Chronic Low Back Pain, Social Participation, and Psychological Distress in Elderly People : A Pilot Mediation Analysis

JaLCDOI	10.18926/AMO/56168
フルテキストURL	72_4_337.pdf
著者	Owari, Yutaka\| Miyatake, Nobuyuki\|
抄録	Several studies indicated that chronic low back pain (CLBP) worsened psychological distress (PD) and social participation (SP) improved PD. The relationships among CLBP, SP and PD have not been established. Here we investigate whether SP mediates the relationship between CLBP and PD in 96 elderly people. We evaluated CLBP and SP by a self-administered questionnaire and PD by K6 questionnaires. We used simple correlation analyses, the unpaired t-test, and a mediation analysis following the approach outlined by Structural Equation Modeling (SEM) to clarify the relationships among CLBP, SP and PD. Using SEM, was observed a significant relationship between CLBP and SP (β=−0.321, p=0.003), a significant negative correlation between SP and K6 scores (β=−0.357, p=0.001), and a significant positive correlation between CLBP and K6 scores (β=0.333, p=0.002). By including SP as a parameter, the coefficient of correlation between CLBP and K6 scores varied from 0.333 (p=0.002) to 0.218 (p=0.035). After bootstrapping, 0 was not included in the 95% confidence interval (0.119, 1.913). SP as a mediator may reduce PD in elderly people with CLBP.
キーワード	psychological distress chronic low back pain social participation mediation analysis
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2018-08
巻	72巻
号	4号
出版者	Okayama University Medical School
開始ページ	337
終了ページ	342
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	30140080