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JaLCDOI 10.18926/AMO/55589
フルテキストURL 71_6_519.pdf
著者 Mizukawa, Nobuyoshi| Swe Swe Win| Zaw Moe Thein| Moe Thida Htwe| Yoshioka, Yohsuke| Kimata, Yoshihiro| Iida, Seiji| Khin, Myo| Okada, Shigeru| Sein, Than|
抄録 Oral cancer is a very common disease in South and Southeast Asia. Betel quid (BQ)- chewing and tobaccosmoking habits are etiological factors for oral cancer patients in these regions. We conducted an oral cancer screening in BQ-chewing endemic rural areas in South Myanmar for the early detection of oral cancer in BQ-chewing and smoking individuals. We examined 105 subjects who were at high risk of oral cancer due to their oral habits (BQ users and/or smokers). Three carcinoma cases were detected, and there were 8 dysplasia cases. The carcinoma detection rate was 2.9%, and the carcinoma and precancerous lesion detection rate was 10.5%. In Myanmar, oral cancer screening has been conducted sporadically on a voluntary basis, and nationwide surveys have never been performed. There are also few reports of oral cancer screening for high-risk groups among the general population in Myanmar. Our present findings highlight the need for further screening and surveys. Education on betel quid chewing- and tobacco- related oral diseases and screening for the early detection of oral cancer are of the utmost importance in the control and prevention of oral cancer.
キーワード oral cancer screening betel quid (BQ) Myanmar oral cancer smoking
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2017-12
71巻
6号
出版者 Okayama University Medical School
開始ページ 519
終了ページ 524
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 29276225
JaLCDOI 10.18926/AMO/55588
フルテキストURL 71_6_513.pdf
著者 Sawada, Shigeki| Sugimoto, Ryujiro| Ueno, Tsuyoshi| Yamashita, Motohiro|
抄録 We evaluated the feasibility of maintenance treatment using UFT (a combination of tegafur and uracil) after adjuvant platinum-based chemotherapy in patients with resected lung cancer. A prospective feasibility trial was conducted. Between 2010 and 2014, UFT was administered for 2 years sequentially after platinum-based adjuvant chemotherapy in 24 patients with resected Stage IIA-IIIA non-small cell lung cancer. The safety of UFT and the rate of treatment completion were then evaluated. The prior platinum-based chemotherapy regimens consisted of cisplatin+vinorelbine in 16 patients, carboplatin+paclitaxel in 5 and carboplatin+S-1 in one. During the subsequent UFT administration, a total of 3 patients required a dose reduction because of Grade 1 blood-stained sputum, Grade 2 numbness, and Grade 2 constipation, in one patient each. Eleven patients underwent the planned 2-year UFT administration, but 12 patients could not because of the recurrence of lung cancer in 5 patients, metachronous malignancy in one, and toxicities in 6. The completion rate for UFT administration was 64.7% (11/17). The most common type of toxicity was gastrointestinal toxicities. All of the toxicities were grade 1 or 2, and no severe toxicities were observed. UFT treatment after platinum-based chemotherapy was revealed to be feasible.
キーワード UFT adjuvant chemotherapy lung cancer resection
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2017-12
71巻
6号
出版者 Okayama University Medical School
開始ページ 513
終了ページ 518
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 29276224
JaLCDOI 10.18926/AMO/55587
フルテキストURL 71_6_505.pdf
著者 Honda, Yoshihiro| Takigawa, Nagio| Ichihara, Eiki| Ninomiya, Takashi| Kubo, Toshio| Ochi, Nobuaki| Yasugi, Masayuki| Murakami, Toshi| Yamane, Hiromichi| Tanimoto, Mitsune| Kiura, Katsuyuki|
抄録 (−)-Epigallocatechin-3-gallate (EGCG) has been shown to bind to several receptors including epidermal growth factor receptor (EGFR). EGFR tyrosine kinase inhibitors and anaplastic lymphoma kinase (ALK) inhibitors are effective for non-small cell lung cancers harboring activating EGFR mutations and ALK or c-ros oncogene 1 (ROS1) fusion genes, respectively. We investigated the effects of EGCG on EGFR- or fusion gene-driven lung cancer cells such as PC-9, RPC-9, H1975, H2228 and HCC78. The five cell lines had similar sensitivity to EGCG. Phosphorylated (p)EGFR, pAkt and pErk in PC-9, RPC-9 and H1975 cells were suppressed by EGCG (50 or 100 μM). EGCG also inhibited pALK in H2228, pROS1 in HCC78, and pErk and pAkt in both cell lines. All the xenograft tumors established using the 5 cell lines in EGCG-treated groups were significantly smaller than the tumors in the vehicle-treated groups. The numbers of tumor blood vessels of xenograft tissues in EGCG-treated mice were significantly lower than those in vehicle-treated mice. In conclusion, EGCG may be effective for EGFR-driven lung tumors irrespective of the presence of T790M, and for ALK or ROS1 fusion gene-driven lung tumors.
キーワード epigallocatechin-3-gallate lung cancer EGFR ALK ROS1
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2017-12
71巻
6号
出版者 Okayama University Medical School
開始ページ 505
終了ページ 512
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 29276223
JaLCDOI 10.18926/AMO/55586
フルテキストURL 71_6_493.pdf
著者 Aoe, Michinori| Ueno-Iio, Tomoe| Shibakura, Misako| Shinohata, Ryoko| Usui, Shinichi| Arao, Yujiro| Ikeda, Satoru| Miyahara, Nobuaki| Tanimoto, Mitsune| Kataoka, Mikio|
抄録 Lavender essential oil (Lvn) has anti-inflammatory effects in an ovalbumin-sensitized murine model of asthma, and inhibits inflammatory cell infiltration into the lungs. The anti-inflammatory effects of Lvn on cell adhesion molecules are not clear. Here we evaluated the effects of Lvn and its main constituents, linalyl acetate (LA) and linalool (LO), on the expression of tumor necrosis factor-alpha (TNF-α)-induced cell adhesion molecules in murine brain endothelial bEnd.3 cells and human umbilical vein endothelial cells (HUVECs). The bEnd.3 cells were treated with Lvn, LA, or LO and subsequently stimulated with TNF-α. The mRNA expression levels of cell adhesion molecules were detected using RT-PCR. E-selectin and P-selectin protein and phosphorylated-NF-κB p65 were detected by western blotting. The effects of Lvn on HUVECs were measured by RT-PCR. In bEnd.3 cells, Lvn and LA suppressed TNF-α-induced E-selectin, P-selectin, vascular cell adhesion molecule-1, intercellular adhesion molecule-1, and phosphorylated-NF-κB p65 in the nucleus; LO did not suppress P-selectin or phosphorylated-NF-κB p65. Lvn inhibited TNF-α-induced E-selectin mRNA in HUVECs. These results indicate that Lvn and LA inhibit TNF-α-induced cell adhesion molecules in endothelial cells through the suppression of NF-κB activation. Consequently, Lvn or other essential oils including LA may be useful as alternative anti-inflammatory medicines.
キーワード lavender essential oil linalyl acetate inflammation cell adhesion molecule NF-κB
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2017-12
71巻
6号
出版者 Okayama University Medical School
開始ページ 493
終了ページ 503
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 29276222
JaLCDOI 10.18926/AMO/55585
フルテキストURL 71_6_485.pdf
著者 Okano, Ayaka| Masuhara, Shun| Ota, Sonoka| Motegi, Chie| Takabayashi, Noriko| Ogino, Tetsuya|
抄録 We examined postprandial body positions’ effects on gastrointestinal motility, the autonomic nervous system and subjective comfort, i.e., whether lowering the head after a meal is beneficial for gastrointestinal motility and the prevention of pressure ulcer. We examined 10 healthy subjects and compared 3 body positions: (1) Seated upright. (2) Lying on a bed with the head at 60° and knees up by 20° (60° position). (3) Identical to (2) until post-meal; the head was then lowered to 30° (60°-30° position). Gastrointestinal motility was assessed as gastrointestinal sounds measured by sound-editing software. Digital plethysmography assessed autonomic nerve function as heart rate variability. The pressure ulcer risk was estimated as subjective comfort/discomfort using a visual analog scale. Gastrointestinal sounds increased post-meal. The 60°-30° position showed the highest number of sounds and longest cumulative sound duration. Post-meal, sympathetic activation was suggested in the 60° position, whereas vagal activity was relatively preserved in the 60°-30° position. The 60°-30° position was the most comfortable, and the 60° position was least comfortable. Lowering the head after a meal is beneficial to augment gastrointestinal motility and decrease the pressure ulcer risk. The 60° head-up position increases the pressure ulcer risk.
キーワード gastrointestinal sound body position autonomic nerve pressure ulcer patient care
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2017-12
71巻
6号
出版者 Okayama University Medical School
開始ページ 485
終了ページ 491
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 29276221
JaLCDOI 10.18926/AMO/55584
フルテキストURL 71_6_475.pdf
著者 Takei, Daisuke| Harada, Keita| Takashima, Shiho| Inokuchi, Toshihiro| Nakarai, Asuka| Sugihara, Yusaku| Takahara, Masanobu| Hiraoka, Sakiko| Okada, Hiroyuki|
抄録 Several reports discussed colonoscopic surveillance after polypectomy and endoscopic mucosal resection (EMR) for colorectal polyps, but only a few reports focused on prognostic analyses, and none involved metachronous neoplasia after colorectal endoscopic submucosal dissection (ESD). We conducted the present study to assess the risk of adenoma recurrence requiring endoscopic treatment, and to establish appropriate post-ESD colonoscopic surveillance. We enrolled 116 patients who had undergone colorectal ESD at Okayama University Hospital between February 2008 and July 2014 and had been followed-up >12 months. We retrospectively analyzed clinicopathological features of 101 lesions from 101 patients. Metachronous adenomas were detected in 21 cases (20.8%). We divided the patients into 2 groups according to the occurrence of metachronous adenomas. Our comparison of clinicopathological characteristics between these groups showed that in the metachronous adenomas group the number of synchronous adenomas at index colonoscopy was high and the rate of laterally spreading tumor-nongranular (LST-NG) was higher. A multivariate analysis indicated that the number of synchronous adenomas was significantly associated with metachronous adenomas (HR: 2.54, 95%CI: 1.04-6.52, p<0.05). The colonoscopic surveillance planning after colorectal ESD should be more meticulous for patients with more synchronous adenomas.
キーワード endoscopic submucosal dissection laterally spreading tumor metachronous recurrence local recurrence post-ESD colonoscopic surveillance
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2017-12
71巻
6号
出版者 Okayama University Medical School
開始ページ 475
終了ページ 483
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 29276220
JaLCDOI 10.18926/AMO/55583
フルテキストURL 71_6_467.pdf
著者 Obata, Kengo| Yumoto, Tetsuya| Fuke, Soichiro| Tsukahara, Kohei| Naito, Hiromichi| Iida, Atsuyoshi| Takahashi, Tetsuya| Ujike, Yoshihito| Nakao, Atsunori|
抄録 Early mobilization is advocated to prevent intensive care unit-acquired physical weakness, but the patient's workload and its changes in response to body position changes have not been established. We used indirect calorimetry to determine the energy expenditure (EE) in response to body position changes, and we assessed EE's correlation with respiratory parameters in healthy volunteers: 8 males and 8 females, mean age 23.4±1.3 years. The subjects started in the resting supine position followed by a 30° head-up position, a 60° head-up position, an upright sitting position, a standing position, and the resting supine position. EE was determined in real time by indirect calorimetry monitoring the subject’s respiratory rate, tidal volume (VT), and minute volume (MV). The highest values were observed immediately after the subjects transitioned from standing to supine, and this was significantly higher compared to the original supine position (1,450±285 vs. 2,004±519 kcal/day, p<0.01). Moderate correlations were observed between VT and EE (r=0.609, p<0.001) and between MV and EE (r=0.576, p<0.001). Increasing VT or MV indicates an increasing patient workload during mobilization. Monitoring these parameters may contribute to safe rehabilitation. Further studies should assess EE in critically ill patients.
キーワード early mobilization energy expenditure indirect calorimetry rehabilitation body position
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2017-12
71巻
6号
出版者 Okayama University Medical School
開始ページ 467
終了ページ 473
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 29276219
JaLCDOI 10.18926/AMO/55582
フルテキストURL 71_6_459.pdf
著者 Sakaguchi, Masakiyo| Kinoshita, Rie| Endy Widya Putranto| I Made Winarsa Ruma| I Wayan Sumardika| Youyi, Chen| Tomonobu, Naoko| Yamamoto, Ken-ichi| Murata, Hitoshi|
抄録 The receptor for advanced glycation end products (RAGE) is involved in inflammatory pathogenesis. It functions as a receptor to multiple ligands such as AGEs, HMGB1 and S100 proteins, activating multiple intracellular signaling pathways with each ligand binding. The molecular events by which ligand-activated RAGE controls diverse signaling are not well understood, but some progress was made recently. Accumulating evidence revealed that RAGE has multiple binding partners within the cytoplasm and on the plasma membrane. It was first pointed out in 2008 that RAGE’s cytoplasmic tail is able to recruit Diaphanous-1 (Dia-1), resulting in the acquisition of increased cellular motility through Rac1/Cdc42 activation. We also observed that within the cytosol, RAGE’s cytoplasmic tail behaves similarly to a Toll-like receptor (TLR4)-TIR domain, interacting with TIRAP and MyD88 adaptor molecules that in turn activate multiple downstream signals. Subsequent studies demonstrated the presence of an alternative adaptor molecule, DAP10, on the plasma membrane. The coupling of RAGE with DAP10 is critical for enhancing the RAGE-mediated survival signal. Interestingly, RAGE interaction on the membrane was not restricted to DAP10 alone. The chemotactic G-protein-coupled receptors (GPCRs) formyl peptide receptors1 and 2 (FPR1 and FPR2) also interacted with RAGE on the plasma membrane. Binding interaction between leukotriene B4 receptor 1 (BLT1) and RAGE was also demonstrated. All of the interactions affected the RAGE signal polarity. These findings indicate that functional interactions between RAGE and various molecules within the cytoplasmic area or on the membrane area coordinately regulate multiple ligand-mediated RAGE responses, leading to typical cellular phenotypes in several pathological settings. Here we review RAGE’s signaling diversity, to contribute to the understanding of the elaborate functions of RAGE in physiological and pathological contexts.
キーワード receptor for advanced glycation end products RAGE adaptor protein signal transduction inflammatory pathogenesis
Amo Type Review
出版物タイトル Acta Medica Okayama
発行日 2017-12
71巻
6号
出版者 Okayama University Medical School
開始ページ 459
終了ページ 465
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 29276218
フルテキストURL jfl_068_contents_eng.pdf
著者 岡山大学文学部|
出版物タイトル 岡山大学文学部紀要
発行日 2017-12-22
68巻
ISSN 0285-4864
言語 日本語
論文のバージョン publisher
JaLCDOI 10.18926/okadai-bun-kiyou/55580
タイトル(別表記) Die Weltgeschichte ist das Weltgericht : Schillers Vers und die deutsche Geschichtsphilosophie des 19. Jahrhunderts
フルテキストURL jfl_068_(017)_(030).pdf
著者 寺岡 孝憲|
出版物タイトル 岡山大学文学部紀要
発行日 2017-12-22
68巻
開始ページ (017)
終了ページ (030)
ISSN 0285-4864
言語 日本語
論文のバージョン publisher
NAID 120006370708
JaLCDOI 10.18926/okadai-bun-kiyou/55579
タイトル(別表記) Die Brautbriefe von Sigmund Freud und Martha Bernays (4): Freuds persönliches Liebesleben als Grundlage der Psychoanalyse
フルテキストURL jfl_068_(001)_(015).pdf
著者 金関 猛|
出版物タイトル 岡山大学文学部紀要
発行日 2017-12-22
68巻
開始ページ (1)
終了ページ (15)
ISSN 0285-4864
関連URL http://ousar.lib.okayama-u.ac.jp/55224
言語 日本語
論文のバージョン publisher
JaLCDOI 10.18926/okadai-bun-kiyou/55578
フルテキストURL jfl_068_085_100.pdf
著者 Renoud, Loïc|
出版物タイトル 岡山大学文学部紀要
発行日 2017-12-22
68巻
開始ページ 85
終了ページ 100
ISSN 0285-4864
言語 英語
論文のバージョン publisher
NAID 120006370706
JaLCDOI 10.18926/okadai-bun-kiyou/55577
フルテキストURL jfl_068_069_083.pdf
著者 Leonard, Julian|
出版物タイトル 岡山大学文学部紀要
発行日 2017-12-22
68巻
開始ページ 69
終了ページ 83
ISSN 0285-4864
言語 英語
論文のバージョン publisher
NAID 120006370705
JaLCDOI 10.18926/okadai-bun-kiyou/55576
タイトル(別表記) Beyond the Blue Notebook: The Transcendental Blue in Paul Auster’s Oracle Night(2003)
フルテキストURL jfl_068_055_068.pdf
著者 中谷 ひとみ|
出版物タイトル 岡山大学文学部紀要
発行日 2017-12-22
68巻
開始ページ 55
終了ページ 68
ISSN 0285-4864
言語 日本語
論文のバージョン publisher
NAID 120006370704
JaLCDOI 10.18926/okadai-bun-kiyou/55575
タイトル(別表記) A Finger Bowl and Li Hung-Chang(3)
フルテキストURL jfl_068_045_054.pdf
著者 遊佐 徹|
出版物タイトル 岡山大学文学部紀要
発行日 2017-12-22
68巻
開始ページ 45
終了ページ 54
ISSN 0285-4864
関連URL http://ousar.lib.okayama-u.ac.jp/53085
言語 日本語
論文のバージョン publisher
NAID 120006370703
JaLCDOI 10.18926/okadai-bun-kiyou/55574
タイトル(別表記) Start of“ The Great Reforms” and Fiscal and Monetary Policy in Imperial Russia
フルテキストURL jfl_068_033_044.pdf
著者 吉田 浩|
出版物タイトル 岡山大学文学部紀要
発行日 2017-12-22
68巻
開始ページ 33
終了ページ 44
ISSN 0285-4864
言語 日本語
論文のバージョン publisher
NAID 120006370702
JaLCDOI 10.18926/okadai-bun-kiyou/55573
タイトル(別表記) Research into Lieutenant Colonel Shinjo’s(新庄) Death : New Documents on PINGXINGGUANDAJIE(平型关大捷)
フルテキストURL jfl_068_019_031.pdf
著者 姜 克實|
出版物タイトル 岡山大学文学部紀要
発行日 2017-12-22
68巻
開始ページ 19
終了ページ 31
ISSN 0285-4864
言語 中国語
論文のバージョン publisher
NAID 120006370701
JaLCDOI 10.18926/okadai-bun-kiyou/55572
タイトル(別表記) A Post-Skinnerian Perspective in Psychology (26): Old Age as a Radical Behaviorist
フルテキストURL jfl_068_001_017.pdf
著者 長谷川 芳典|
抄録  本稿は、行動分析学の視点から、高齢者のライフスタイルの構築と終末に関する有用な知見を提供することを目的とする。このテーマは、 (1)スキナーの幸福観の概要と高齢者への適用 (2)選択機会と高齢者の行動的QOL (3)複数の行動のまとまりから構成される「活動」概念に基づいて、より巨視的な観点から高齢者のライフスタイルの構築を考える (4)終末期における不安や恐怖への対処 という4つの観点から総合的に検討する必要があると考えるが、本稿では紙幅の制限により、(2)についてはすでに長谷川(2012, 2013)で論じているのでここでは省略し、また(1)と(4)は概略を述べるにとどめ、新しい概念を取り入れた(3)について重点的に取り上げていくことにしたい。
出版物タイトル 岡山大学文学部紀要
発行日 2017-12-22
68巻
開始ページ 1
終了ページ 17
ISSN 0285-4864
関連URL http://ousar.lib.okayama-u.ac.jp/55220
言語 日本語
論文のバージョン publisher
NAID 120006370700
フルテキストURL jfl_068_contents.pdf
著者 岡山大学文学部|
出版物タイトル 岡山大学文学部紀要
発行日 2017-12-22
68巻
ISSN 0285-4864
言語 日本語
論文のバージョン publisher
フルテキストURL K0005600_other1.pdf
著者 Takeda, Tatsuaki| Yamamoto, Hiromasa| Kanzaki, Hirotaka| Suzawa, Ken| Yoshioka, Takahiro| Tomida, Shuta| Cui, Xiaojiang| Murali, Ramachandran| Namba, Kei| Sato, Hiroki| Torigoe, Hidejiro| Watanabe, Mototsugu| Shien, Kazuhiko| Soh, Junichi| Asano, Hiroaki| Tsukuda, Kazunori| Kitamura, Yoshihisa| Miyoshi, Shinichiro| Sendo, Toshiaki| Toyooka, Shinichi|
備考 学位審査副論文|
発行日 2017-02-03
出版物タイトル PLoS One
12巻
2号
出版者 Public Library of Science
開始ページ e0171356
ISSN 1932-6203
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン publisher
PubMed ID 28158234
DOI 10.1371/journal.pone.0171356
Web of Science KeyUT 000396161700064
関連URL isVersionOf https://doi.org/10.1371/journal.pone.0171356 isPartOf http://ousar.lib.okayama-u.ac.jp/55525