検索結果 13656 件
| JaLCDOI | 10.18926/bgeou/52424 |
|---|---|
| タイトル（別表記） | Evoked potentials in patients with Angelman syndrome |
| フルテキストURL | 108_0037_0040.pdf |
| 著者 | 眞田 敏| 小川 和則| 大守 伊織| 荻野 竜也| 石田 喬士| |
| 抄録 | Evoked potentials were studied in four cases with Angelman syndrome. Chromosome 15ql1-13 deletion was proved in two cases and paternal uniparental disomy was proved in the rest. Prolonged photo-evoked eyelid microvibration latencies were noted in all four， while visual evoked potential latencies remained within normal limits in three of four. Interpeak latencies of wave I to wave V in auditory brainstem response were prolonged in two of four. Short latency somatosensory evoked potential was examined in two cases and prolonged interpeak latency of wave P3 to wave N1 was noted in one case. Brink reflex was examined in one case and prolonged R2 latency was noted. These findings suggest that the brainstem is disturbed in cases with Angelman syndrome. |
| キーワード | Angelman syndrome severely handicapped evoked potentials photic stimulation brink reflex |
| 出版物タイトル | 岡山大学教育学部研究集録 |
| 発行日 | 1998-07-15 |
| 巻 | 108巻 |
| 開始ページ | 37 |
| 終了ページ | 40 |
| ISSN | 0471-4008 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 120005425642 |
| 著者 | Sakata, Kenichiro| Furumatsu, Takayuki| Miyazawa, Shinichi| Okada, Yukimasa| Fujii, Masataka| Ozaki, Toshifumi| |
|---|---|
| 発行日 | 2013-01 |
| 出版物タイトル | International Orthopaedics |
| 巻 | 37巻 |
| 号 | 1号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Putranto, Endy Widya| Murata, Hitoshi| Yamamoto, Ken-Ichi| Kataoka, Ken| Yamada, Hidenori| Futami, Jun-Ichiro| Sakaguchi, Masakiyo| Huh, Nam-Ho| |
|---|---|
| 発行日 | 2013-10 |
| 出版物タイトル | International Journal of Molecular Medicine |
| 巻 | 32巻 |
| 号 | 4号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/52408 |
|---|---|
| フルテキストURL | 68_2_119.pdf |
| 著者 | Takeda, Akiko| Shimada, Akira| Hamamoto, Kazuko| Yoshino, Syuuji| Nagai, Tomoko| Fujii, Yousuke| Yamada, Mutsuko| Nakamura, Yoshimi| Watanabe, Toshiyuki| Watanabe, Yuki| Yamamoto, Yuko| Sakakibara, Kanae| Oda, Megumi| Morishima, Tsuneo| |
| 抄録 | Acute megakaryocytic leukemia (AMKL) with t(1;22)(p13;q13) is a distinct category of myeloid leukemia by WHO classification and mainly reported in infants and young children. Accurate diagnosis of this type of AMKL can be difficult, because a subset of patients have a bone marrow (BM) blast percentage of less than 20% due to BM fibrosis. Therefore, it is possible that past studies have underestimated this type of AMKL. We present here the case of a 4-month-old female AMKL patient who was diagnosed by presence of the RBM15-MKL1 (OTT-MAL) fusion transcript by RT-PCR. In addition, we monitored RBM15-MKL1 fusion at several time points as a marker of minimal residual disease (MRD), and found that it was continuously negative after the first induction chemotherapy even by nested RT-PCR. Detection of the RBM15-MKL1 fusion transcript thus seems to be useful for accurate diagnosis of AMKL with t(1;22)(p13;q13). We recommend that the RBM15-MKL1 fusion transcript be analyzed for all suspected AMKL in infants and young children. Furthermore, monitoring of MRD using this fusion transcript would be useful in treatment of AMKL with t(1;22)(p13;q13). |
| キーワード | AMKL infant RBM15-MKL1 OTT-MAL |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2014-04 |
| 巻 | 68巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 119 |
| 終了ページ | 123 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 24743787 |
| Web of Science KeyUT | 000334652700007 |
| JaLCDOI | 10.18926/AMO/52406 |
|---|---|
| フルテキストURL | 68_2_101.pdf |
| 著者 | Izutsu, Masato| Suzuki, Etsuji| Izutsu, Yukako| Doi, Hiroyuki| |
| 抄録 | The aim of this study was to examine trends in the geographic distribution of nursing staff in Japan from 2000 to 2010. We examined time trends in the rates of nursing staff per 100,000 population across 349 secondary health service areas. Using the Gini coefficient as a measure of inequality, we separately analyzed the data of 4 nursing staff types:public health nurses (PHN), midwives (MW), nurses (NS), and associate nurses (AN). Then, using multilevel Poisson regression models, we calculated the rate ratios (RRs) and their 95% confidence intervals (CIs) for each type of nursing staff per 1-year change. Overall, the distribution of PHN, MW, and NS improved slightly in terms of the Gini coefficient. After adjusting for prefectural capital and population density, PHN, MW, and NS significantly increased;the RRs per 1-year increment were 1.022 (95% CI:1.020-1.023), 1.021 (95% CI:1.019-1.022), and 1.037 (95% CI:1.037-1.038), respectively. In contrast, AN significantly decreased;the RR per 1-year increment was 0.993 (95% CI:0.993-0.994). Despite the considerable increase in the absolute number of nursing staff in Japan (excluding AN), this increase did not lead to a sufficient improvement in distribution over the last decade. |
| キーワード | health policy inequality Japan multilevel Poisson model nursing staff |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2014-04 |
| 巻 | 68巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 101 |
| 終了ページ | 110 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 24743785 |
| Web of Science KeyUT | 000334652700005 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/52523 |
| JaLCDOI | 10.18926/AMO/52405 |
|---|---|
| フルテキストURL | 68_2_89.pdf |
| 著者 | Sako, Shinichi| Kariyama, Reiko| Mitsuhata, Ritsuko| Yamamoto, Masumi| Wada, Koichiro| Ishii, Ayano| Uehara, Shinya| Kokeguchi, Susumu| Kusano, Nobuchika| Kumon, Hiromi| |
| 抄録 | We conducted a study on molecular epidemiology and clinical implications of metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa isolated from urine. Over a 10-year period from 2001 through 2010, a total of 92 MBL-producing P. aeruginosa urine isolates were collected from patients (one isolate per patient) who were admitted to 5 hospitals in Okayama Prefecture, Japan. When cross-infection was suspected in the hospital, pulsed-field gel electrophoresis was performed. In the resulting dendrogram of 79 MBL-producing P. aeruginosa urine isolates, no identical isolates and 7 pairs of isolates with ≥80% similarity were found. The biofilm-forming capabilities of 92 MBL-producing P. aeruginosa urine isolates were significantly greater than those of 92 non-MBL-producing urine isolates in a medium of modified artificial urine. The imipenem resistance transferred in 16 of 18 isolates tested, and these frequencies were in the range of 10－3 to 10－9. All of 18 isolates tested belonged to internationally spread sequence type 235 and had 3 gene cassettes of antimicrobial resistance genes in the class 1 integron. The strong biofilm-forming capabilities of MBL-producing P. aeruginosa urine isolates could be seriously implicated in nosocomial infections. To prevent spread of the organism and transferable genes, effective strategies to inhibit biofilm formation in medical settings are needed. |
| キーワード | Pseudomonas aeruginosa metallo-β-lactamase molecular epidemiology biofilm urinary tract infection |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2014-04 |
| 巻 | 68巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 89 |
| 終了ページ | 99 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 24743784 |
| Web of Science KeyUT | 000334652700004 |
| 関連URL | http://ousar.lib.okayama-u.ac.jp/metadata/52504 |
| JaLCDOI | 10.18926/AMO/52404 |
|---|---|
| フルテキストURL | 68_2_79.pdf |
| 著者 | Mu-Mu-Shwe| Harano, Teruo| Okada, Shigeru| Aye-Aye-Win| Khin-Saw-Aye| Hlaing-Myat-Thu| Mo-Mo-Win| Khin-Khin-Oo| Myo-Khin| |
| 抄録 | This study aimed to determine the prevalence of normal and abnormal cervical cytology in women who attended the cervical cancer screening clinic of the Department of Medical Research in Lower Myanmar, and to determine the proportion of high-risk (HR) human papillomavirus (HPV) infection and HPV genotypes in women with normal and abnormal cervical cytology. A total of 1,771 women were screened from 2010 to 2011. Among them, 762 women (43.0%) had a normal smear, and 866 (48.9%) and 87 (4.9%) were diagnosed with inflammatory smears and atypical squamous cells of undetermined significance (ASCUS), respectively. Diagnoses of low-grade squamous intraepithelial lesion (LSIL) and high-grade squamous intraepithelial lesion (HSIL) numbered 42 (2.3%) and 11 (0.6%) respectively. Three cases of squamous cell carcinoma (SCC) (0.2%) were detected. Cervical swabs were collected from 96 women with abnormal cervical cytology and 20 with normal cytology. HR-HPV DNA testing was performed by polymerase chain reaction (PCR) with pU1M/pU2R primers. HR-HPV were identified in 35.5% (22/62) of inflammatory smears, 60% (6/10) of ASCUS, 86.7% (13/15) of LSIL, 50% (3/6) of HSIL, 100% (3/3) of SCC and 5% (1/20) of normal cytology. In PCR-positive cases, HPV genotyping was analyzed by the cleaved amplification polymorphism method. The most prevalent HPV genotypes were HPV-16 (60.4%) followed by HPV-31 (14.6%), HPV-18 (12.5%) and HPV-58 (12.5%). Women with abnormal cervical cytology were 10 times more likely to be HR-HPV positive than those with normal cytology (p＝0.0001). This study suggests that the implementation of a cervical cytology screening program and routine vaccination against HPV in preadolescent and adolescent groups are needed to reduce the burden of HPV-associated cervical cancer. |
| キーワード | human papillomavirus cervical neoplasia genotyping Myanmar |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2014-04 |
| 巻 | 68巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 79 |
| 終了ページ | 87 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 24743783 |
| Web of Science KeyUT | 000334652700003 |
| JaLCDOI | 10.18926/AMO/52403 |
|---|---|
| フルテキストURL | 68_2_63.pdf |
| 著者 | Fujii, Yasuyuki| Hoshino, Tyuji| Kumon, Hiromi| |
| 抄録 | Dickkopf (DKK) proteins interact with low-density lipoprotein receptor-related protein 5/6 (LRP5/6) to modulate WNT signaling. The interaction is mediated by a cysteine-rich domain (C2) in the DKK protein and β-propeller domains (PD) of LRP5/6. However, the third member of the DKK family (DKK3) does not bind to LRP5/6. To determine why DKK3 does not bind to the receptor domains, we performed a molecular modeling simulation study including homology modeling, protein-protein docking and molecular dynamics (MD). The computed affinities (ΔGbinding) between the C2 and PD models were consistent with the previously reported experimental results. The C2 model of DKK3 showed the lowest affinity for PD models. Multiple sequence alignment of C2 domains revealed that the DKK3 genes have a unique 7-amino-acid insertion (L249-E255 in human DKK3) and P258 in a finger loop 1 (FL1). Interestingly, the insertion sequence is evolutionally conserved. MD simulations of high-affinity complex models of C2 and PD showed that FL1 directly interacts with the PD models and stabilizes the complex models. We also built a 7-amino-acid-deletion/P258G mutant model of DKK3C2 and estimated its affinities for the PD models. The affinity for human LRP5PD2 was increased by the substitution (ΔGbinding＝－48.9kcal/mol) and the affinity was compatible with that of high-affinity ligands. The results suggested that the lack of affinity between human DKK3 and human LRP5/6 results from: i) insertion of the 7 amino acids, and ii) P258 in human DKK3. The sequence differences thus suggest an explanation for this unique property of DKK3. |
| キーワード | DKK3 molecular modeling protein-protein docking LRP5/6 |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2014-04 |
| 巻 | 68巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 63 |
| 終了ページ | 78 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2014 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 24743782 |
| Web of Science KeyUT | 000334652700002 |
| 著者 | 加藤 内藏進| 加藤 晴子| 佐藤 紗里| 山田 悠海| 赤木 里香子| 大谷 和男| |
|---|---|
| 発行日 | 2014-02 |
| 出版物タイトル | 環境制御 |
| 巻 | 35巻 |
| 資料タイプ | 紀要論文 |
| JaLCDOI | 10.18926/52384 |
|---|---|
| タイトル（別表記） | A Study of Understanding of "temo" by Japanese Learners based on a Questionnaire Conducted on Chinese-speakers |
| フルテキストURL | hss_037_113_0127.pdf |
| 著者 | 宮崎 聡子| |
| 出版物タイトル | 岡山大学大学院社会文化科学研究科紀要 |
| 発行日 | 2014-03-25 |
| 巻 | 37巻 |
| 開始ページ | 113 |
| 終了ページ | 127 |
| ISSN | 1881-1671 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2014 岡山大学大学院社会文化科学研究科 |
| 論文のバージョン | publisher |
| NAID | 120005418226 |
| JaLCDOI | 10.18926/52380 |
|---|---|
| タイトル（別表記） | A Study on Chinese-Kana (Japanese characters reflecting Chinese pronunciations) in Daishin-Bunten (A Chinese grammar text) |
| フルテキストURL | hss_037_095_0112.pdf |
| 著者 | 張 照旭| |
| 出版物タイトル | 岡山大学大学院社会文化科学研究科紀要 |
| 発行日 | 2014-03-25 |
| 巻 | 37巻 |
| 開始ページ | 95 |
| 終了ページ | 112 |
| ISSN | 1881-1671 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2014 岡山大学大学院社会文化科学研究科 |
| 論文のバージョン | publisher |
| NAID | 120005418224 |
| JaLCDOI | 10.18926/52374 |
|---|---|
| タイトル（別表記） | On Petrow’s Study of "Lexicon" (the 18th century Russian-Japanese dictionary), Part2 |
| フルテキストURL | hss_037_001_011.pdf |
| 著者 | 江口 泰生| |
| 出版物タイトル | 岡山大学大学院社会文化科学研究科紀要 |
| 発行日 | 2014-03-25 |
| 巻 | 37巻 |
| 開始ページ | 1 |
| 終了ページ | 11 |
| ISSN | 1881-1671 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2014 岡山大学大学院社会文化科学研究科 |
| 論文のバージョン | publisher |
| NAID | 120005418218 |
| 著者 | 岡山大学大学院文化科学研究科| |
|---|---|
| 発行日 | 2014-03-26 |
| 出版物タイトル | 文化共生学研究 |
| 巻 | 13巻 |
| 資料タイプ | その他 |
| 著者 | 朴 珍希| |
|---|---|
| 発行日 | 2014-03-26 |
| 出版物タイトル | 文化共生学研究 |
| 巻 | 13巻 |
| 資料タイプ | 紀要論文 |
| JaLCDOI | 10.18926/52371 |
| 著者 | 町 聡志| |
|---|---|
| 発行日 | 2014-03-26 |
| 出版物タイトル | 文化共生学研究 |
| 巻 | 13巻 |
| 資料タイプ | 紀要論文 |
| JaLCDOI | 10.18926/52370 |
| 著者 | ダルクラン アイシェ ヌル| |
|---|---|
| 発行日 | 2014-03-26 |
| 出版物タイトル | 文化共生学研究 |
| 巻 | 13巻 |
| 資料タイプ | 紀要論文 |
| JaLCDOI | 10.18926/52369 |
| JaLCDOI | 10.18926/52368 |
|---|---|
| タイトル（別表記） | Awareness and Behavior about Eating in Japanese Students: As a Contrast Group for Developing Cross-cultural Dietary Education for International Students in Japan |
| フルテキストURL | scs_013_115_121.pdf |
| 著者 | 田中 共子| 高濱 愛| |
| 出版物タイトル | 文化共生学研究 |
| 発行日 | 2014-03-26 |
| 巻 | 13巻 |
| 開始ページ | 115 |
| 終了ページ | 121 |
| ISSN | 1880-9162 |
| 言語 | 日本語 |
| 著作権者 | Copyright © 2014 岡山大学大学院社会文化科学研究科 |
| 論文のバージョン | publisher |
| NAID | 120005411306 |
| 著者 | 高谷 幸| 大曲 由起子| 樋口 直人| 鍛治 致| 稲葉 奈々子| |
|---|---|
| 発行日 | 2014-03-26 |
| 出版物タイトル | 文化共生学研究 |
| 巻 | 13巻 |
| 資料タイプ | 紀要論文 |
| JaLCDOI | 10.18926/52367 |
| 著者 | 高谷 幸| 大曲 由起子| 樋口 直人| 鍛治 致| 稲葉 奈々子| |
|---|---|
| 発行日 | 2014-03-26 |
| 出版物タイトル | 文化共生学研究 |
| 巻 | 13巻 |
| 資料タイプ | 紀要論文 |
| JaLCDOI | 10.18926/52366 |
| 著者 | 倉地 克直| |
|---|---|
| 発行日 | 2014-03-26 |
| 出版物タイトル | 文化共生学研究 |
| 巻 | 13巻 |
| 資料タイプ | 紀要論文 |
| JaLCDOI | 10.18926/52365 |