検索結果 - 岡山大学学術成果リポジトリ

Effects of hydrogen-rich water on aging periodontal tissues in rats

著者	Tomofuji, Takaaki\| Kawabata, Yuya\| Kasuyama, Kenta\| Endo, Yasumasa\| Yoneda, Toshiki\| Yamane, Mayu\| Azuma, Tetsuji\| Ekuni, Daisuke\| Morita, Manabu\|
発行日	2014-07-02
出版物タイトル	Scientific Reports
巻	4巻
資料タイプ	学術雑誌論文

Mutual interaction of kisspeptin, estrogen and bone morphogenetic protein-4 activity in GnRH regulation by GT1-7 cells

著者	Terasaka, Tomohiro\| Otsuka, Fumio\| Tsukamoto, Naoko\| Nakamura, Eri\| Inagaki, Kenichi\| Toma, Kishio\| Ogura-Ochi, Kanako\| Glidewell-Kenney, Christine\| Lawson, Mark A.\| Makino, Hirofumi\|
発行日	2013-12-05
出版物タイトル	Molecular and Cellular Endocrinology
巻	381巻
号	1-2号
資料タイプ	学術雑誌論文

Serum Levels of Soluble Adhesion Molecules as Prognostic Factors for Acute Liver Failure

著者	Ohnishi, Atsuyuki\| Miyake, Yasuhiro\| Matsushita, Hiroshi\| Matsumoto, Kazuyuki\| Takaki, Akinobu\| Yasunaka, Tetsuya\| Koike, Kazuko\| Ikeda, Fusao\| Shiraha, Hidenori\| Nouso, Kazuhiro\| Yamamoto, Kazuhide\|
発行日	2012
出版物タイトル	Digestion
巻	86巻
号	2号
資料タイプ	学術雑誌論文

Impaired response of hypoxic sensor protein HIF-1 alpha and its downstream proteins in the spinal motor neurons of ALS model mice

著者	Sato, Kota\| Morimoto, Nobutoshi\| Kurata, Tomoko\| Mimoto, Takafumi\| Miyazaki, Kazunori\| Ikeda, Yoshio\| Abe, Koji\|
発行日	2012-09-14
出版物タイトル	Brain Research
巻	1473巻
資料タイプ	学術雑誌論文

Reducing Hemorrhagic Complication by Dabigatran Via Neurovascular Protection After Recanalization With Tissue Plasminogen Activator in Ischemic Stroke of Rat

著者	Kono, Syoichiro\| Deguchi, Kentaro\| Omote, Yoshio\| Yunoki, Taijun\| Yamashita, Toru\| Kurata, Tomoko\| Ikeda, Yoshio\| Abe, Koji\|
発行日	2014-01
出版物タイトル	Journal of Neuroscience Research
巻	92巻
号	1号
資料タイプ	学術雑誌論文

Clinical and Pathological Improvement in Stroke-Prone Spontaneous Hypertensive Rats Related to the Pleiotropic Effect of Cilostazol

著者	Omote, Yoshio\| Deguchi, Kentaro\| Tian, FengFeng\| Kawai, Hiromi\| Kurata, Tomoko\| Yamashita, Toru\| Ohta, Yasuyuki\| Abe, Koji\|
発行日	2012-06
出版物タイトル	Stroke
巻	43巻
号	6号
資料タイプ	学術雑誌論文

Therapy for hyperthermia-induced seizures in Scn1a mutant rats

著者	Hayashi, Keiichiro\| Ueshima, Satoshi\| Ouchida, Mamoru\| Mashimo, Tomoji\| Nishiki, Teiichi\| Sendo, Toshiaki\| Serikawa, Tadao\| Matsui, Hideki\| Ohmori, Iori\|
発行日	2011-05
出版物タイトル	Epilepsia
巻	52巻
号	5号
資料タイプ	学術雑誌論文

Quantitation and Human Monocyte Cytotoxicity of the Polymerization Agent 1-Hydroxycyclohexyl Phenyl Ketone (Irgacure 184) from Three Brands of Aqueous Injection Solution

著者	Yamaji, Kazuhiko\| Kawasaki, Yoichi\| Yoshitome, Kei\| Matsunaga, Hisashi\| Sendo, Toshiaki\|
発行日	2012-10
出版物タイトル	Biological & Pharmaceutical Bulletin
巻	35巻
号	10号
資料タイプ	学術雑誌論文

The integrin inhibitor cilengitide enhances the anti-glioma efficacy of vasculostatin-expressing oncolytic virus

著者	Fujii, K\| Kurozumi, K\| Ichikawa, T\| Onishi, M\| Shimazu, Y\| Ishida, J\| Chiocca, EA\| Kaur, B\| Date, I\|
発行日	2013-08
出版物タイトル	Cancer Gene Therapy
巻	20巻
号	8号
資料タイプ	学術雑誌論文

Novel 3D-CT evaluation of carotid stent volume: greater chronological expansion of stents in patients with vulnerable plaques

著者	Itami, Hisakazu\| Tokunaga, Koji\| Okuma, Yu\| Hishikawa, Tomohito\| Sugiu, Kenji\| Ida, Kentaro\| Date, Isao\|
発行日	2013-09
出版物タイトル	Neuroradiology
巻	55巻
号	9号
資料タイプ	学術雑誌論文

A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem-like Cells in S/G(2)/M Phases

著者	Yano, Shuya\| Tazawa, Hiroshi\| Hashimoto, Yuuri\| Shirakawa, Yasuhiro\| Kuroda, Shinji\| Nishizaki, Masahiko\| Kishimoto, Hiroyuki\| Uno, Futoshi\| Nagasaka, Takeshi\| Urata, Yasuo\| Kagawa, Shunsuke\| Hoffman, Robert M.\| Fujiwara, Toshiyoshi\|
発行日	2013-12-01
出版物タイトル	Clinical Cancer Research
巻	19巻
号	23号
資料タイプ	学術雑誌論文

For Vol.68, No.3 pp157-162 Usefulness of High Mobility Group Box 1 Protein as a Plasma Biomarker in Patient with Peripheral Artery Disease

JaLCDOI	10.18926/AMO/52792
フルテキストURL	68_4_253.pdf
著者	Oozawa, Susumu\| Sano, Shunji\| Nishibori, Masahiro\|
抄録	Atherosclerosis is often associated with chronic vascular inflammation. High-mobility group box 1 protein (HMGB1) plays various roles, not only as a transcriptional regulatory factor in the nucleus, but also as an inflammatory mediator. A previous study suggested that fibrinogen is an important factor associated with atherosclerosis progression. The present study was performed to examine the levels of plasma HMGB1 protein in atherosclerosis patients. We studied 24 patients with peripheral artery disease (PAD) with atherosclerosis, and 10 healthy controls. We found that the concentrations of HMGB1 were increased in the plasma of the patients with atherosclerosis, and there were significant correlations between the plasma HMGB1 and fibrinogen levels. Plasma HMGB1 may play a key role in the pathogenesis of clinical and experimental atherosclerosis.
キーワード	HMGB1 fibrinogen atherosclerosis peripheral artery disease
Amo Type	Erratum
出版物タイトル	Acta Medica Okayama
発行日	2014-08
巻	68巻
号	4号
出版者	Okayama University Medical School
開始ページ	253
終了ページ	253
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
Web of Science KeyUT	000340687500008
関連URL	http://doi.org/10.18926/AMO/52656

Renal Distribution of Vasohibin-1 in Patients with Chronic Kidney Disease

JaLCDOI	10.18926/AMO/52788
フルテキストURL	68_4_219.pdf
著者	Hinamoto, Norikazu\| Maeshima, Yohei\| Saito, Daisuke\| Yamasaki, Hiroko\| Tanabe, Katsuyuki\| Nasu, Tatsuyo\| Watatani, Hiroyuki\| Ujike, Haruyo\| Kinomura, Masaru\| Sugiyama, Hitoshi\| Sonoda, Hikaru\| Kanomata, Naoki\| Sato, Yasufumi\| Makino, Hirofumi\|
抄録	Experimental studies have demonstrated the involvement of angiogenesis-related factors in the progression of chronic kidney disease (CKD). There have so far been no reports investigating the distribution and clinical roles of Vasohibin-1 (VASH-1), a negative feedback regulator of angiogenesis, in CKD. We recruited 54 Japanese CKD patients and 6 patients who had normal renal tissues excised due to localized renal cell carcinoma. We evaluated the correlations between the renal expression level of VASH-1 and the clinical/histological parameters. VASH-1 was observed in renal endothelial/mesangial cells, crescentic lesions and interstitial inflammatory cells. Significant positive correlations were observed between 1) crescent formation and the number of VASH-1+ cells in the glomerulus (r＝0.48, p＝0.001) or cortex (r＝0.64, p＜0.0001), 2) interstitial cell infiltration and the number of VASH-1+ cells in the cortex (r＝0.34, p＝0.02), 3) the glomerular VEGFR-2+ area and the number of VASH-1+ cells in the glomerulus (r＝0.44, p＝0.01) or medulla (r＝0.63, p＝0.01). These results suggest that the renal levels of VASH-1 may be affected by local inflammation, crescentic lesions and VEGFR-2.
キーワード	chronic kidney disease inflammation Vasohibin-1 VEGF-A VEGFR-2
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2014-08
巻	68巻
号	4号
出版者	Okayama University Medical School
開始ページ	219
終了ページ	233
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	25145408
Web of Science KeyUT	000340687500004
関連URL	http://ousar.lib.okayama-u.ac.jp/metadata/52824

A Questionnaire Study on Attitudes toward Birth and Child-rearing of University Students in Japan, China,and South Korea

JaLCDOI	10.18926/AMO/52787
フルテキストURL	68_4_207.pdf
著者	Yu, Liling\| Kato, Yutaka\| Shishido, Keisuke\| Doi, Hideko\| Jin, Haeng mi\| Wang, Jin gang\| Ikezawa, Junko\| Awaya, Tsuyoshi\|
抄録	This study examines the attitudes of young Japanese, Chinese, and South Koreans toward birth and child-rearing. The survey targeted four-year university students (n＝1,668) who responded to an anonymous survey using self-report questionnaires between December 2012 and April 2013. The collection rates were 72.5%, 94.7%, and 96.5% for the Japanese, Chinese, and South Korean students, respectively. Correlations among the respondentsʼ attributes, medical and scientific literacy levels, and views of preferred qualities of children were analyzed using chi-square test, supplemented by residual analysis (significance level set at p＜0.05). Participants were asked whether they were willing to use the following methods for obtaining preferred qualities in their children:(1) choosing a spouse (43.2%, 72.6%, and 85.1% of the Japanese, Chinese, and South Koreans, respectively, agreed);(2) using a sperm bank (cryobank) (5.8%, 60.1%, and 81.7% of the Japanese, Chines, and South Koreans, respectively, agreed);and (3) using an egg cell bank (ova bank or cryobank) (5.3%, 47.2%, and 70.3% of the Japanese, Chinese, and South Koreans, respectively, agreed). The proportion of affirmative responses (indicating “eugenic inclination”) to these statements was significantly higher among the Chinese and South Korean participants than their Japanese counterparts (p＜0.001). Significant differences were also found in the attitudes of the 3 groups toward methods for obtaining the preferred qualities for their children:prenatal diagnosis, pre-implantation diagnosis, the environment during pregnancy, and child-rearing.
キーワード	prenatal diagnosis pre-implantation diagnosis delivery and child-rearing eugenics healthy birth and child-rearing
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2014-08
巻	68巻
号	4号
出版者	Okayama University Medical School
開始ページ	207
終了ページ	218
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	25145407
Web of Science KeyUT	000340687500003
関連URL	http://ousar.lib.okayama-u.ac.jp/metadata/52823

Two-Directional Arthrographic Assessment for Treating Bilateral Development Dislocation of the Hips in Children after Walking Age

JaLCDOI	10.18926/AMO/52786
フルテキストURL	68_4_201.pdf
著者	Endo, Hirosuke\| Akazawa, Hirofumi\| Mitani, Shigeru\| Okada, Yoshiki\| Yamane, Kentaro\| Ozaki, Toshifumi\|
抄録	We reviewed the treatment outcome in 14 hips of 7 patients who were diagnosed as having bilateral developmental dislocation of the hip (DDH) after walking age and could be followed up until they were at least 14 years of age. Based on the results of two-directional arthrography of the hip, closed reduction was performed in 2 hips, and open reduction was performed without osteotomy in 12 hips. The final radiographic evaluations were made according to the Kalamchi and MacEwen classification and Severin classification. The mean age at the initial visit was 1 year and 9 months (range, 1 year and 5 months to 3 years). The outcome was satisfactory for one hip in Group Ⅰ and 2 hips in Group Ⅱ according to the Kalamchi and MacEwen classification, and in 83% of the Severin Class Ⅰ and Ⅱ hips. Arthrography was useful for identifying asymmetry, demonstrating the usefulness of a treatment strategy based on arthrography of the hip.
キーワード	developmental dislocation of the hip bilateral case arthrogram open reduction after walking age
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2014-08
巻	68巻
号	4号
出版者	Okayama University Medical School
開始ページ	201
終了ページ	206
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	25145406
Web of Science KeyUT	000340687500002

Drug Resistance to EGFR Tyrosine Kinase Inhibitors for Non-small Cell Lung Cancer

JaLCDOI	10.18926/AMO/52785
フルテキストURL	68_4_191.pdf
著者	Shien, Kazuhiko\| Yamamoto, Hiromasa\| Soh, Junichi\| Miyoshi, Shinichiro\| Toyooka, Shinichi\|
抄録	Non-small cell lung cancer (NSCLC) harboring an activating mutation within the epidermal growth factor receptor (EGFR) was defined as a clinically distinct molecular group. These lesions show oncogene addiction to EGFR and dramatic responses to the EGFR tyrosine kinase inhibitors (TKIs). Several large Phase III trials have shown that EGFR-TKIs improved the progression-free survival of patients with EGFR mutant NSCLC compared to conventional chemotherapy. However, the long-term effectiveness of EGFR-TKIs is usually limited because of acquired drug resistance. To overcome this resistance to EGFR-TKIs, it will be essential to identify the specific mechanisms underlying the resistance. Many investigators have attempted to identify the mechanisms using preclinical models and drug-resistant clinical samples. As a result, several mechanisms have been showed to be responsible for the resistance, but not all of the relevant mechanisms have been uncovered. In this review, we provide an overview of mechanisms underlying drug-resistance to EGFR-TKIs, focusing on results obtained with preclinical models, and we present some possible strategies to overcome the EGFR-TKI resistance.
キーワード	non-small cell lung cancer EGFR mutation tyrosine-kinase inhibitor drug resistance cancer stem cell
Amo Type	Review
出版物タイトル	Acta Medica Okayama
発行日	2014-08
巻	68巻
号	4号
出版者	Okayama University Medical School
開始ページ	191
終了ページ	200
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2014 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	25145405
Web of Science KeyUT	000340687500001

高齢者の友人関係が主観的幸福感に及ぼす影響（その１） ― 香川県さぬき市の老人大学受講生を対象として ―

JaLCDOI	10.18926/bgeou/52779
タイトル（別表記）	The Effects of Friendship Relationships of the Aged upon their Subjective Well-being: The Case of Participants in a College for the Elderly in a Small City in Japan (Part Ⅰ)
フルテキストURL	bgeou_156_039_048.pdf
著者	野邊政雄\| 大須賀翼\|
抄録	本稿の目的は，高齢者が取り結んでいる友人関係のどのような側面が主観的幸福感に影響を及ぼすかを明らかにすることである。地方小都市である香川県さぬき市で老人大学の受講生を対象にサーベイ調査を2012 年に実施した。この調査データの分析によって，次の２点を明らかにした。（1）サポートの授受を伴う友人関係ではなく，交遊する友人関係が高齢者の主観的幸福感に影響を及ぼしていた。そして，交遊する友人関係を多く取り結んでいる高齢者ほど，高い主観的幸福感をもっていた。（2）交遊する友人関係のなかでは，年賀状の交換をする友人関係，お茶を飲んだり食事をしたりする友人関係が高齢者の主観的幸福感に影響を及ぼしていた。そして，年賀状の交換をする友人関係，お茶を飲んだり食事をしたりする友人関係を多く取り結んでいる高齢者ほど，高い主観的幸福感をもっていた。
キーワード	香川県さぬき市高齢者友人関係主観的幸福感老人大学
出版物タイトル	岡山大学大学院教育学研究科研究集録
発行日	2014-07-28
巻	156巻
開始ページ	39
終了ページ	48
ISSN	1883-2423
言語	日本語
論文のバージョン	publisher
NAID	120005464807

発達障害をともなう子どもへのRey-Osterrieth 複雑図形検査の臨床応用

JaLCDOI	10.18926/bgeou/52775
タイトル（別表記）	Clinical application of the Rey-Osterrieth Complex Figure Test for children with developmental disorders
フルテキストURL	bgeou_156_007_013.pdf
著者	眞田敏\| 池田葵\| Higa Diez, Midory\| 加戸陽子\| 荻野竜也\| 中野広輔\| 山根大輝\| 横内理絵\| 濃野信\|
抄録	本研究では，10 名の読みや書きなどの学習面に困難を抱える発達障害をともなう子どもにWechsler式知能検査およびRey-Osterrieth複雑図形検査（ROCF）を実施し，認知特性の実態把握の過程におけるROCFの有用性を検討した。ROCFの記録には被検者の描画過程をデータ化してパソコンに取り込むことのできるタッチペン（Inkling™）を用い，成績評価には，描画の質的評価も含むBoston Qualitative Scoring System （BQSS）を用いた。 Wechsler式知能検査における知覚統合や知覚推理の下位検査の得点が良好であっても， ROCFにおいて構成力や描画過程に困難が少なからず認められ，これらは学習面における困難の背景にある病態を反映したものと考えられた。また，本検査成績を検討する上で， BQSSの概要得点の1 つである組織構成，概要得点に含まれていないクラスター要素や細部要素の配置の評価の重要性についても論じた。
キーワード	Rey-Osterrieth複雑図形検査（ROCF） Boston Qualitative Scoring System (BQSS) Inkling™ 神経心理学的検査発達障害
出版物タイトル	岡山大学大学院教育学研究科研究集録
発行日	2014-07-28
巻	156巻
開始ページ	7
終了ページ	13
ISSN	1883-2423
言語	日本語
論文のバージョン	publisher
NAID	120005464803

Utilization of the Inkling™ for the Rey - Osterrieth Complex Figure test

JaLCDOI	10.18926/bgeou/52774
フルテキストURL	bgeou_156_001_005.pdf
著者	Sanada, Satoshi\| Higa Diez, Midory\| Yamane, Daiki\| Kado, Yoko\| Nakano, Kousuke\| Ogino, Tatsuya\|
抄録	The Rey - Osterrieth Complex Figure (ROCF) test assess visual-construction abilility, visual memory and executive function. Three different methods are traditionally used to track and to record the strokes during the production of the complex figure: single pen, switching felt pens and flowcharts. The Inkling™ is an instrument which attributes are to track, to record and to save the information of every stroke depicted in a standard piece of paper. The purpose of the study is to examine the advantages and disadvantages of using the Inkling™ in the ROCF test. 66 ROCF performances were analyzed from subjects aged 6 to 86 years old. Each subject performed the ROCF test twice; first with pen switching method without flowcharts and later with the Inkling™ or viceversa. The comparison of the performances evidenced 5 characteristics: Four subjects distracted by the color of the felt pens, three subjects interfered by the switching of the felt pens, three subjects which performance was facilitated by the colors of the felt pens, nine subjects with unclear score for Fragmentation and fourteen subjects with unclear score for Planning. The advantages that the Inkling™ showed were compensation for the process of flowcharts, avoid interference, and reduce the burden of unclear scoring for Fragmentation and Planning.
キーワード	Rey-Osterrieth Complex Figure test cognitive assessment executive function switching felt pens method Inkling™.
出版物タイトル	岡山大学大学院教育学研究科研究集録
発行日	2014-07-28
巻	156巻
開始ページ	1
終了ページ	5
ISSN	1883-2423
言語	英語
論文のバージョン	publisher
NAID	120005464802

表紙・目次

著者	岡山大学大学院教育学研究科\|
発行日	2014-07-28
出版物タイトル	岡山大学大学院教育学研究科研究集録
巻	156巻
資料タイプ	その他