検索結果 - 岡山大学学術成果リポジトリ

Evaluation of Body Surface Temperature by Thermography 2. Effect of Pre-loading with Hot Water

JaLCDOI	10.18926/14963
タイトル（別表記）	サーモグラフィーによる体表面温度の測定 2.温水負荷の効果
フルテキストURL	069_068_075.pdf
著者	保崎泰弘\| 高田真吾\| 光延文裕\| 御舩尚志\| 芦田耕三\| 柘野浩史\| 岡本誠\| 原田誠之\| 谷崎勝朗\| 越智浩二\| 原田英雄\| 辻孝夫\|
抄録	The body surface temperature of 41 patients suffering coldness, numbness or pain in their feet was examined using thermography. Thermographic results were analyzed quantitatively by calculating a recovery ratio as: Recovery ratio =[Total counts of thermography (Pixels) over temperature (T) after cold loading] ÷ [Initial counts over T before cold loading] x 100(%). Three different baseline temperatures, 26℃. 27℃ and 28℃, were used in processing the thermographic results into pictures. The recovery ratio was susceptible to temperature, and we recommend a baseline temperature limitation of 27℃ for clinical study. A bi-modal distribution of recovery ratio was observed in 18 patients with diabetes mellitus. One group (6 subjects) had high recovery ratio between 80%-100%, and another group (10 subjects) had a low recovery ratio between 0%-19%. The results of thermography were also influenced by weather. To reduce the effect of outside temperature, we used pre-loading with hot water at 36℃ for 5 min (hot loading).　A large difference in　recovery ratio between presence and absence of hot loading was observed in 6 of the 30 subjects. The difference was over-estimated in more than 20% of recovery ratio without hot loading as compared with hot loading in these 6 subjects. The effect of drugs on peripheral circulation, such as beraprost sodium and sarpogrelate hydrochloride, was clear and quantified using thermography under these conditions of hot loading.
キーワード	サーモグラフィー (thermography) 糖尿病 (diabetes mellitus) 末梢循環 (peripheral circulation) 冷水負荷 (cold loading) 温水負荷 (hot loading)
出版物タイトル	岡大三朝分院研究報告
発行日	1998-12
巻	69巻
開始ページ	68
終了ページ	75
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308316

Abnormalities of gastric mucous membrane in patients with steroid-dependent intractable asthma

JaLCDOI	10.18926/14962
タイトル（別表記）	ステロイド依存性重症難治性気管支喘息症例における胃粘膜病変の検討
フルテキストURL	069_063_067.pdf
著者	御舩尚志\| 光延文裕\| 保崎泰弘\| 芦田耕三\| 柘野浩史\| 原田誠之\| 岡本誠\| 湯本英一朗\| 高田真吾\| 谷崎勝朗\|
抄録	Recently, we experienced two asthmatic patients with advanced gastric cancer. The two patients had steroid-dependent intractable asthma (SDIA) who had been on administration of corticosteroids for more than 2 years. To determine the influence of pathophysiology of SDIA on stomach mucous lesion, gastroscopic examinations and immunological examinations were performed in eight patients with SDIA, compared with 25 patient with non-SDIA. In patients with SDIA, gastric cancer, its precursor condition and immunosuppressive state were observed. These results suggest that the immunosuppressive state in SDIA induced by the long-term administration of corticosteroids may lead to the risk of gastric cancer development.
キーワード	ステロイド依存性重症難治性 (steroid-dependent intractable asthma (SDIA)) 胃癌 (gastric cancer) 免疫抑制 (immunosuppression) リンパ球 (lymphocytes) IgG
出版物タイトル	岡大三朝分院研究報告
発行日	1998-12
巻	69巻
開始ページ	63
終了ページ	67
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308665

Long-term administration of Clarithromycin for an asthmatic patient with mucosal abnormalities of sinonasal cavity

JaLCDOI	10.18926/14961
タイトル（別表記）	鼻腔･副鼻腔疾患を合併する気管支喘息症例に対するクラリスロマイシン投与の効果
フルテキストURL	069_057_062.pdf
著者	御舩尚志\| 光延文裕\| 保崎泰弘\| 芦田耕三\| 柘野浩史\| 原田誠之\| 岡本誠\| 湯本英一朗\| 高田真吾\| 谷崎勝朗\|
抄録	We experienced a case of 59-year-old woman with intractable asthma, who had aspirin intolerance. Despite various treatments including systemic corticosteroid administration, she was often admitted due to severe asthma attacks. Furthermore, she had allergic rhinitis and sinusitis. Computed tomography (CT) scans of sinonasal cavity revealed marked thickness of nasal mucosa and air-fluid level in maxillary sinuses. Although her asthma symptoms such as wheezing and dyspnea were improved by administration of bronchodilator, systemic corticosteroids and beclomethasone diisoccyanate (BDI) accompanied with spa therapy, her peak expiratory flow (PEF) showed no improvement. After readmission due to asthma attacks, clarithromycin (CAM) administration for sinonasal disorders was started. The PEF value showed marked improvement after starting CAM administration, and pulmonary functions and bronchial hyperresponsiveness were also improved. It is suggested from her clinical course that CAM may have beneficial effects in asthmatic patients with sinonasal disorders.
キーワード	bronchial asthma allergic rhinitis sinusitis clarithromycin peak expiratory flow (PEF)
出版物タイトル	岡大三朝分院研究報告
発行日	1998-12
巻	69巻
開始ページ	57
終了ページ	62
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308388

A patient with pulmonary emphysema treated by diet therapy with α-linolenic acid-enriched perilla seed oil.

JaLCDOI	10.18926/14960
タイトル（別表記）	n-3系脂肪散を強化した食事療法が有効と考えられた肺気腫の一例
フルテキストURL	069_049_056.pdf
著者	柘野浩史\| 芦田耕三\| 光延文裕\| 御舩尚志\| 岡本誠\| 保崎泰弘\| 谷崎勝朗\| 辻孝夫\|
抄録	An effective treatment for the advanced stages of chronic obstructive pulmonary disease (COPD) has not been established yet. We report our recent experience of one patient with pulmonary emphysema treated by dietary supplementation of n-3 fatty acid for two months. He presented improvements in clinical symptoms and pulmonary function, and suppression of leukotriene B(4) generation by peripheral leukocytes. We consequently suppose that dietary treatment with n-3 fatty acids (perilla seed oil) may offer benefits for the treatment of pulmonary emphysema by competitively inhiabiting the conversion of arachidonicacid to leukotrienes and prostanoids.
キーワード	pulmonary emphysema n-3 fatty acid leukotriene diet therapy
出版物タイトル	岡大三朝分院研究報告
発行日	1998-12
巻	69巻
開始ページ	49
終了ページ	56
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308253

The clinical effects of dietary supplementation with n-3 fatty acids in bronchial asthma compared with n-6 fatty acids.

JaLCDOI	10.18926/14959
タイトル（別表記）	n-3系脂肪酸食の気管支喘息に対する臨床効果:n-6系脂肪酸との比較
フルテキストURL	069_040_048.pdf
著者	岡本誠\| 芦田耕三\| 光延文裕\| 御舩尚志\| 保崎泰弘\| 柘野浩史\| 原田誠之\| 湯本英一朗\| 高田真吾\| 谷崎勝朗\| 片岡幹男\| 原田実根\|
抄録	N-3 fatty acids, such as fish oil, have been reported to have some beneficial effects in patients with bronchial asthma by suppressing leukocyte function, followed by reduction of the need for pharmacologic agents. To examine the effects of dietary supplementation with perilla seed oil rich in α-linolenic acid (ALA), 23 patients with　asthma took corn oil rich in linoleic acid (LA) for the former two weeks, perilla seed oil for the later two weeks. The asthmatic patients were classified into two groups by the changes of the generation of leukotrienes B4 (LTB4), C4 (LTC4), and B5 (LTB5) during the two courses of dietary modification: one was sensitive to dietary modification, and the other was insensitive to dietary supplementation. We compared the two groups in clinical characteristics. Significant differences were observed in peak flow (PEF), forced expiratory volume in one second (FEV1.0), IgE, sex, obesity index (OI), concentration of serum total cholesterol, albumin, low density lipoprotein {LDL)-cholesterol, β-lipoprotein and phospholipids between two groups. This study indicated that these factors influence the generation of LTB4, C4 and B5 of asthmatic patients in dietary supplementation.
キーワード	n-3系脂肪酸 (n-3 fatty acids) エゴマ油 (perilla seed oil) 気管支喘息 (bronchial asthma) LTB4 LTC4
出版物タイトル	岡大三朝分院研究報告
発行日	1998-12
巻	69巻
開始ページ	40
終了ページ	48
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308199

A Case of Giant Cell Arteritis Associated with Rheumatoid Arthritis Monitored by Magnetic Resonance Angiography

JaLCDOI	10.18926/14956
タイトル（別表記）	MR-angiographyで経過を観察しえた慢性関節リウマチに合併した巨細胞動脈炎の1例
フルテキストURL	069_035_039.pdf
著者	原田誠之\| 光延文裕\| 兒玉富美子\| 保崎泰弘\| 御舩尚志\| 柘野浩史\| 岡本誠\| 湯本英一朗\| 高田真吾\| 谷崎勝朗\|
抄録	We report a patient who developed giant cell (temporal) arteritis during treatment of rheumatoid arthritis. The patient was a 57-year-old Japanese woman and had been well controlled with anti-rheumatic drugs, when she presented to our hospital with severe bitemporal headaches and marked fatigue. An exclusive diagnosis was rapidly made and she was diagnosed as having giant cell arteritis based on the classification criteria by American College of Reumatology. Additionally, magnetic resonance (MR) angiography was performed, from which stenotic change in the bilateral superficial temporal arteries was strongly suspected and then corticosteroid therapy was quickly started. The patient followed an uneventful course without developing any complications such as visual dysfunctions. Therapeutic effect was confirmed by MR-angiographic findings obtained 4 weeks after the initiation of therapy.
キーワード	巨細胞動脈炎 (giant cell arteritis) 側頭動脈炎 (temporal arteritis) 慢性関節リウマチ (rheumatoid arthritis) MRアンギオグラフィー (MR-angiography)
出版物タイトル	岡大三朝分院研究報告
発行日	1998-12
巻	69巻
開始ページ	35
終了ページ	39
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308121

Correlation between decrease in % FVC and airway inflammation in patients with asthma, classified by clinical symptoms

JaLCDOI	10.18926/14955
タイトル（別表記）	気管支喘息患者における努力肺活量(% FVC)の低下と気道炎症ならびに臨床病型との関連
フルテキストURL	069_028_034.pdf
著者	光延文裕\| 御舩尚志\| 保崎泰弘\| 芦田耕三\| 横田聡\| 柘野浩史\| 谷崎勝朗\| 越智浩二\| 原田英雄\|
抄録	Clinical features of asthmatics with a low % FVC (<80%) were studied in relation to airway inflammation and clinical asthma types. 1. Twenty four (75.0%) of the 32 subjects with a low % FVC had steroid-dependent intractable asthma. 2. A significant association between % FVC value and clinical asthma type was found. The value of % FVC was significantly lower in subjects with type II asthma (bronchiolar obstruction), in which significantly decreased proportion of lymphocytes,and significantly increased proportion of neutrophils in bronchoalveolar lavage (BAL) fluid were observed, than in those with type la-1 (simple bronchoconstriction) with (P<0.001) and without glucocorticoid therapy (P<0.02). 3. The % FVC value was significantly improved after treatment in type lb (hypersecretion) with BAL eosinophilia, but not in those with type II with BAL neutrophilia. These results demonstrate that marked decrease of % FVC in patients with asthma correlated with airway inflammation, and that airway reversibility by medication is very low in patients with type II asthma.
キーワード	ventilatory function FEV1.0 bronchoalveolar lavage bronchial reversibility
出版物タイトル	岡大三朝分院研究報告
発行日	1998-12
巻	69巻
開始ページ	28
終了ページ	34
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308252

IgE antibodies against inhalant allergens in patients with pulmonary emphysema

JaLCDOI	10.18926/14954
タイトル（別表記）	肺気腫患者における吸入抗原に対するIgE抗体
フルテキストURL	069_021_027.pdf
著者	光延文裕\| 御舩尚志\| 保崎泰弘\| 芦田耕三\| 柘野浩史\| 岡本誠\| 原田誠之\| 湯本英一郎\| 高田真吾\| 谷崎勝朗\| 越智浩二\| 原田英雄\| 長谷川晴巳\|
抄録	To analyze the pathophysiological changes ot the airways in emphysema, bronchial responsiveness and the generation of leukotrienes B4 (LTB4) and C4 (LTC4) by peripheral leucocytes were examined in 22 patients with emphysema. The subjects were divided into two groups according to the presence or absence of IgE antibodies against inhalant allergens; RAST positive group and RAST negative group. 1. Smoking history, mean CT number and mean maximum % low attenuation area (% LAA) <-950HU of the lung on high resolution computed tomography (HRCT), and DLco value suggested that there were emphysematous changes of the lung in all subjects. However, these findings were not different between the two groups. 2. The level of serum IgE was significantly higher in RAST positive group than in RAST negative group. 3. The mean % increase in FEV1.0 after inhalation of β-agonists was higher in RAST positive group than in RAST negative group. The % increase more than 15% was found in 4 of the 9 subjects (44.4%) in RAST positive group and 2 of the 12 (16.7%) in RAST negative group. 4. The generation of LTC4 by leucocytes was significantly higher in RAST positive group than in RAST negative group (p<0.01). The generation of LTB4 was not significantly different between the two groups. The results suggest that IgE-mediated allergy participates in the bronchial responsiveness of patients with emphysema.
キーワード	emphysema bronchial responsiveness FEV1.0 LTB4 LTC4
出版物タイトル	岡大三朝分院研究報告
発行日	1998-12
巻	69巻
開始ページ	21
終了ページ	27
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308178

Association of the mean CT number by high resolution computed tomography (HRCT) with generation of leukotrienes B4 (LTB4) and C4 (LTC4) in patients with pulmonary emphysema

JaLCDOI	10.18926/14953
タイトル（別表記）	肺気腫患者におけるロイコトリエンB4,C4産生能と高分解能CTによる平均CT値との関連
フルテキストURL	069_015_020.pdf
著者	光延文裕\| 御舩尚志\| 保崎泰弘\| 芦田耕三\| 柘野浩史\| 岡本誠\| 原田誠之\| 湯本英一郎\| 高田真吾\| 越智浩二\| 原田英雄\| 長谷川晴巳\|
抄録	The generation of leukotrienes B4 (LTB4) and C4 (LTC4) by peripheral leukocytes stimulated with Ca ionophore A23187 was examined in 17 patients with pulmonary emphysema. They were divided into three groups according to the mean CT number; A (<-940 HU), B (-940 ≦, <-930 HU), and C (-930 HU ≦ ).1. The values of FVC (% predicted), FEV1.0% and DLco (% predicted) showed a tendency to decrease as the mean CT number was smaller. The value of % FVC was significantly lower in patients with group A than in those with group C (p<0.05). 2. The generation of both LTB4 and LTC4 was significantly higher in patients with emphysema compared to the generation in healthy subjects (LTB4;p<0.05, LTC4;P<0.05). 3. The generation of LTB4 and LTC4 in patients with emphysema was higher as the mean CT number was larger (severity of the disease become less). The LTC4 production was significantly higher in patients with group C(mild or moderate type of emphysema) than in those with group A(advanced type of emphysema). These results suggest that the generation of LTB4 and LTC4 is higher in patients with mild or moderate type of emphysema than in those with advanced type of the disease.
キーワード	emphysema mean CT number LTB4 LTC4
出版物タイトル	岡大三朝分院研究報告
発行日	1998-12
巻	69巻
開始ページ	15
終了ページ	20
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308094

Leukotrienes B4 and C4 generation by peripheral leucocytes in patients with asthma

JaLCDOI	10.18926/14951
タイトル（別表記）	気管支喘息における末梢血白血球のロイコトリエンB4およびC4産生能
フルテキストURL	069_009_014.pdf
著者	谷崎勝朗\| 光延文裕\| 御舩尚志\| 保崎泰弘\| 芦田耕三\| 柘野浩史\| 岡本誠\| 原田誠之\| 湯本英一郎\| 高田真吾\| 越智浩二\| 原田英雄\|
抄録	The generation of leukotrienes B4 (LTB4) and C4 (LTC4) by leucocytes stimulated with Ca ionophore A23187 was examined in 16 patients with asthma (8 with atopic and 8 with nonatopic asthma) and 12 healthy controls. 1. The LT84 generation by leucocytes was not significantly different between patients with asthma and healthy controls. The generation of LTC4 was significantly larger in patients with asthma than in healthy controls. The LTC4 generation was also significantly larger in patients with attacks (58.4 ± 38.5 ng/5x10(6) cells) than in those without attacks (23.3 ± 25.9 ng/5x10(6) cells)(p<0.05). 2.ln atopic asthma, the LTC4 production was significantly larger in patients with attacks (84.7 ± 35.4 ng/5x10(6) cells) compared to the production in those without attacks (40.4 ± 27.2 ng/5x10(6) cells)(p<0.02). However, the production of LTB4 was not significantly different between attack and attack-free stages. 3. In nonatopic asthma, the LTC4 production was also significantly higher in patients with attacks (32.2 ± 26.3 ng/5x10(6) cells) than in those without attacks (12.2 ± 3.5 ng/5x10(6) cells)(p<0.05). However, the LTB4 production was not significantly different between attack and nonattack stages. 4. The LTC4 production was significantly larger in atopic asthmatics compared to the production in nonatopic subjects both in attack and nonattack stages. These results suggest that the generation of LTC4 by leucocytes of patients with asthma is closely related to IgE-mediated reaction and asthma attacks.
キーワード	bronchial asthma LTB4 LTC4 IgE-mediated reaction asthma attacks
出版物タイトル	岡大三朝分院研究報告
発行日	1998-12
巻	69巻
開始ページ	9
終了ページ	14
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308181

慢性閉塞性呼吸器疾患に対する温泉療法の臨床的評価.最近5年間(1993年- 1997年)の入院症例511例を対象に

JaLCDOI	10.18926/14950
タイトル（別表記）	Clinical significance of spa therapy in the treatmentof patients with chronic obstructive pulmonary disease (COPD). A study on 511 patients with COPD admitted for last 5 years
フルテキストURL	069_001_008.pdf
著者	谷崎勝朗\| 光延文裕\| 御舩尚志\| 保崎泰弘\| 芦田耕三\| 柘野浩史\| 岡本誠\| 原田誠之\| 湯本英一郎\| 高田真吾\| 越智浩二\| 原田英雄\|
抄録	1993年1月より1997年12月までの5ヵ年間に当院へ入院した慢性閉塞性呼吸器疾患511例を対象に,疾患の種類,年齢,地域分布などについて検討を加えた｡1.最近5年間に当院へ入院した呼吸器疾患患者は594例で,このうち,慢性閉塞性呼吸器疾患患者は511例(86.0%)であった｡これらの慢性閉塞性呼吸器疾患のなかでは,気管支喘息が416例(81.4%)と最も多く,その他.慢性気管支炎20例,閉塞性細気管支炎27例,肺気腫48例であった｡2.慢性閉塞性呼吸器疾患のなかでは,肺気腫の症例が増加する傾向が見られた｡3.慢性閉塞性呼吸器疾患の年齢別検討では,鳥取県内では,70才以上の症例が,また遠隔地(鳥取県外)では60-69才の症例の頻度が高い傾向が見られた｡4.入院患者の地域分布では,鳥取県内からの入院患者に比べ,遠隔地(鳥取県外)からの入院患者が比較的多く,その比率は1997年度で48.4%であった｡また,その分布別検討では,岡山県,兵庫県,大阪府,広島県,山口県,愛媛県からの入院患者が多い傾向が見られた｡
キーワード	慢性閉塞性呼吸器疾患 (COPD) 気管支喘息 (bronchial asthma) 温泉療法 (spa therapy) 高齢患者 (aged patients) 遠隔地 (distant area)
出版物タイトル	岡大三朝分院研究報告
発行日	1998-12
巻	69巻
開始ページ	1
終了ページ	8
ISSN	0918-7839
言語	日本語
論文のバージョン	publisher
NAID	120002308114

呼吸器疾患及び疼痛性疾患に対する温泉療法の臨床評価

JaLCDOI	10.18926/14944
タイトル（別表記）	Clincal evaluation of spa effects for patients with respiratory disease and chronic pain disease
フルテキストURL	070_088_092.pdf
著者	西村伸子\| 寺崎佳代\| 山本貞枝\| 中村寿美江\|
抄録	1998年1月より12月までの1年間に,温泉療法-主として温泉プール水泳ないし歩行訓練及び鉱泥湿布治療-を受けた158例の入院症例(呼吸器疾患78例,疼痛性疾患64例,その他16例)について退院時に臨床効果を5段階で評価してもらいそれぞれの入院期間との比較検討を行った｡対象症例の年齢は70才代が最も多く,次いで60才代,50才代,80才代であった｡地域分布では,鳥取県外の入院症例が72.2%を占め,県外である遠隔地としては,岡山県,兵庫県,広島県,大阪府,東京都,神奈川県からの入院が多く見られた｡臨床効果は,"非常に良くなった"と,"かなり良くなった"を有効と判定し,その有効率は呼吸器疾患では78.2%であった｡一方,疼痛性疾患では,その有効率は50.0%であったが,"少し良くなった"症例を含めると,95.3%,その他の症例は68.8%であった｡入院期間別に検討すると,呼吸器疾患では入院1ケ月で72.7%,2ケ月では81.8%,3ケ月以上では76.5%であった｡一方,疼痛性疾患では,入院1ケ月で21.1%,2ケ月で60.0%,3ケ月で64.0%であり,呼吸器疾患と比べ,効果出現までの期間がやヽ長く,入院期間が長くなるほど,その効果は高くなる傾向が見られた｡
キーワード	温泉療法 (spa therapy) 呼吸器疾患 (respiratory disease) 慢性疼痛性疾患 (chronic pain disease)
出版物タイトル	岡大三朝分院研究報告
発行日	1999-12
巻	70巻
開始ページ	88
終了ページ	92
ISSN	0918-7839
言語	日本語
論文のバージョン	publisher
NAID	120002308358

慢性関節リウマチ患者の温泉治療効果に関する要因の分析

JaLCDOI	10.18926/14941
タイトル（別表記）	Analysis of Factors Regarding Spa Therapy in Patients with Rheumatoid Arthritis
フルテキストURL	070_073_078.pdf
著者	吉尾慶子\| 田熊正栄\| 能見真由美\| 中村寿美江\| 原田誠之\| 谷崎勝朗\|
抄録	1998年4月より9月までの6ヶ月間に当院へ入院し温泉療法をうけた慢性関節リウマチ患者6例を対象に,温泉治療経験の有無,年齢,機能障害度(クラス),罹患年数の4項目が温泉療法効果に及ぼす影響につき検討した｡温泉治療経験の有無では治療経験を有する患者においてMHAQ(modified health assessment questionnaile),患者による疼痛評価,患者による全般活動性評価に有意な改善が見られ,年齢(75才以上,75才未満)では,75才未満においてMHAQに有意な改善傾向が見られた｡機能障害度(クラス3以上,クラス2以下),罹患年数(15年以上,15年未満)においては有意差は見られなかった｡温泉の永続効果を保つためには,年1～2回の入院を繰り返すことが効果的であることが示唆された｡
キーワード	慢性関節リウマチ温泉療法
出版物タイトル	岡大三朝分院研究報告
発行日	1999-12
巻	70巻
開始ページ	73
終了ページ	78
ISSN	0918-7839
言語	日本語
論文のバージョン	publisher
NAID	120002308424

The relationship between the magnetic resonance imaging of the lumbar spine and low back pain

JaLCDOI	10.18926/14936
タイトル（別表記）	腰椎MRI画像と腰痛の関係
フルテキストURL	070_067_072.pdf
著者	高田真吾\| 湯本英一朗\| 岡本誠\| 柘野浩史\| 原田誠之\| 保崎泰弘\| 御舩尚志\| 光延文裕\| 谷崎勝朗\| 原田実根\|
抄録	The purpose of this study was to examine the potential role of magnetic resonance imaging (MRI) in the evaluation of low back pain (LBP). The study group, 19 patients with low back pain (2 subjects aged 32-39 years and 17 aged 59-78), underwent MRI of the lumbar spine. Disc degeneration at L4/5 was the most common finding (68.4%). Overall in present study, all patients with LBP had abnormalities around the lumbar spine (evidence of disc degeneration, deformity of lumbar spine, disc bulging or protrusion, facet hypertrophy, nerve root compression and so on).
キーワード	MRI (Magnetic resonance imaging) 腰椎 (Lumbar spine) 椎間板変性 (Disc disease)
出版物タイトル	岡大三朝分院研究報告
発行日	1999-12
巻	70巻
開始ページ	67
終了ページ	72
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308559

Churg-Strauss症候群の再燃を来した気管支喘息症例

JaLCDOI	10.18926/14935
タイトル（別表記）	A Case of Recurrent Churg-Strauss Syndrome Associated with Bronchial Asthma
フルテキストURL	070_061_066.pdf
著者	原田誠之\| 柘野浩史\| 光延文裕\| 御舩尚志\| 保崎泰弘\| 芦田耕三\| 岡本誠\| 高田真吾\| 山本敏雄\| 谷崎勝朗\|
抄録	入院中にChurg-Strauss症候群の再燃を来した症例を報告した｡症例は気管支喘息を有する73歳の女性で,持続する両下肢の知覚障害を主訴に当院に入院した｡入院2週頃より微熱,下腹部不快感が続き右下肢のdrop foot,下血を呈した｡末梢血では著明な好酸球増多を認め,内視鏡検査で直腸潰瘍を認めた。3年前の両下肢の知覚障害出現時にも同様の症状を経験しており,Churg-Strauss症候群の再燃と診断し,ステロイド治療を開始することにより新たな後遺症を残すことなく寛解に至った｡Churg-Strauss症候群の発症･再燃の機序を考える上で貴重な症例と考え,文献的考察を加え報告する｡
キーワード	Churg-Strauss症候群 (Churg-Strauss syndrome) アレルギー性肉芽腫性血管炎 (allergic granulomatous angiitis) 血管炎症候群 (vasculitis syndrome) 気管支喘息 (bronchial asthma) 好酸球増多 (eosinophilia)
出版物タイトル	岡大三朝分院研究報告
発行日	1999-12
巻	70巻
開始ページ	61
終了ページ	66
ISSN	0918-7839
言語	日本語
論文のバージョン	publisher
NAID	120002308532

Cortical bone porosity in patients with asthma

JaLCDOI	10.18926/14934
タイトル（別表記）	気管支喘息症例における皮質骨海綿化
フルテキストURL	070_053_060.pdf
著者	柘野浩史\| 中井睦郎\| 岡本誠\| 原田誠之\| 高田真吾\| 御舩尚志\| 光延文裕\| 芦田耕三\| 保崎泰弘\| 穐山恒雄\| 辻孝夫\| 谷崎勝朗\|
抄録	In previous studies, we have demonstrated that chronic administration of systemic glucocorticoids decreases cortical bone mineral density (BMD), cortical bone volume, bone strength, and induces development of pathologic fractures in asthmatic patients. We have also demonstrated that glucocorticoid administration appears to be responsible for the process of cortical bone porosity at both endosteal and intracortical sites in postmenopausal asthmatic patients. There is a difference of gonadal hormones between male and female. To investigate the influence of hormonal difference on glucocorticoid-induced cortical bone porosity, we studied cortical bone volume and BMD in both male and female patients with asthma in this report. A total of 99 asthmatic patients (male 26 cases, female 73 cases) were enrolled in the study. Peripheral quantitative computed tomography (pQCT) was used to measure cortical BMD and relative cortical volume. The cortical volume-density relationship appeared to remain constant regardless of the level of systemic glucocorticoid administration, age or sex, suggesting cortical bone porosity causes similar and simultaneous decreases in cortical bone volume and density. In conclusion, glucocorticoid administration appears to be responsible for the process of cortical bone porosity at both endosteal and intracortical sites despite the gonadal hormonal differences.
キーワード	bronchial asthma systemic glucocorticoid cortical bone cortical porosity peripheral quantitative computed tomography
出版物タイトル	岡大三朝分院研究報告
発行日	1999-12
巻	70巻
開始ページ	53
終了ページ	60
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308477

Factors influencing the effects of dietary supplementation　with PUFAs on leukotriene generation by leucocytes in　patients with asthma

JaLCDOI	10.18926/14933
タイトル（別表記）	気管支喘息患者における白血球ロイコトリエン産生能に対する不飽和脂肪酸食の効果に影響する因子
フルテキストURL	070_043_052.pdf
著者	岡本誠\| 光延文裕\| 芦田耕三\| 御舩尚志\| 保崎泰弘\| 柘野浩史\| 原田誠之\| 高田真吾\| 谷崎勝朗\| 片岡幹男\| 新谷憲治\| 原田実根\|
抄録	Dietary supplementation with perilla seed oil, a vegetable oil rich in α -lin- olenic acid, inhibits the generation of leukotrienes(LTs) by leucocytes in patients with bronchial asthma. We examined the factors that affect the suppression of LT generation by leucocytes with perilla seed oil-rich supplementation in patients with asthma, by comparing the clinical features of patients with asthma, whose generation of leukotriene (LT) C4 was suppressed by dietary supplementation with perilla seed oil (n-3 fatty acids) (group A), with those of patients who showed no suppression of LTC4 generation (group B). Group A showed a significant increase in the generation of LTB4 and L TC4 by leucocytes after corn oil-rich supplementation (n-6 fatty acids), and a significant decrease in the generation of LTB4 and LTC4 after perilla seed oil-rich supplementation (n-3 fatty acid). However, this was not observed in group B. The level of serum IgE and peak expiratory flow (PEF) in group A were significantly higher than in group B. Furthermore, the serum levels of LDL-cholesterol, β-lipoprotein and　phospholipid were significantly lower in group A than in group B. These results suggest that the clinical features differ between these two asthmatic populations with respect to suppression of LTB4 and LTC4 generation by n-3 fatty acids in perilla seed oil-rich supplementation.
キーワード	エゴマ油 (perilla seed oil) 気管支喘息 (bronchial asthma) ロイコトリエン (leukotrienes) IgE 脂質代謝 (lipometabolism)
出版物タイトル	岡大三朝分院研究報告
発行日	1999-12
巻	70巻
開始ページ	43
終了ページ	52
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308623

Evaluation of Body Surface Temperature by Thermography 3. Correlation between the peripheral circulation estimatedby Laser-Doppler blood flowmetry and thermography.

JaLCDOI	10.18926/14927
タイトル（別表記）	サーモグラフィーによる体表面温度の測定 3.体表面温度の回復率と末消血流量との相関
フルテキストURL	070_036_042.pdf
著者	保崎泰弘\| 高田真吾\| 光延文裕\| 御舩尚志\| 芦田耕三\| 柘野浩史\| 岡本誠\| 原田誠之\| 谷崎勝朗\| 越智浩二\| 辻孝夫\|
抄録	The body surface peripheral circulation in 12 cases,　including 9 patients with　diabetes mellitus who were suffering coldness, numbness or pain in their feet, and 3 healthy volunteers was examined using Laser-Doppler blood flowmetry. At the same time, the body surface temperature was estimated by thermography. Thermographic results were analyzed quantitatively by calculating a recovery ratio as : Recovery ratio = [Total counts of thermography(Pixels) over temperature (T) after cold loading] ÷ [Initial counts over T before cold loading] x 100(%). The recovery ratio and the blood flow were correlated, r=0.68, p
キーワード	サーモグラフィー (thermography) レーザードプラー血流計 (Laser-Doppler blood flowmetry) 糖尿病 (diabetes mellitus) 末梢循環 (peripheral circulation) 冷水負荷 (cold loading)
出版物タイトル	岡大三朝分院研究報告
発行日	1999-12
巻	70巻
開始ページ	36
終了ページ	42
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308240

Relationship between bronchial hyperresponsivenessand nasosinus lesions in patients with bronchial asthma

JaLCDOI	10.18926/14926
タイトル（別表記）	気管支喘息症例における気道過敏性と鼻腔･副鼻腔疾患の関係に関する検討
フルテキストURL	070_028_035.pdf
著者	御舩尚志\| 高田真吾\| 岡本誠\| 柘野浩史\| 芦田耕三\| 原田誠之\| 光延文裕\| 保崎泰弘\| 谷崎勝朗\| 原田実根\|
抄録	Pathological changes of nasosinus occur often in subjects with bronchial asthma. Coexisting nasosinus lesion may affect pathophysiology of lower respiratory tract in asthmatics. The extent of nasal and sinus lesion was quantified in 17 patients with bronchial asthma, and their relationships to atopic status, asthma severity and bronchial hyperresponsiveness were evaluated in this study. Opacification degree of maxillary sinuses and nasal mucosa thickening were quantified using CT scans. The opacification degree was evaluated as (total opacification area)/(total maxillary sinus area). Although the opacification degree of maxillary sinuses in atopic patients showed no significant difference compared with that in non-atopic patients, maximum nasal mucosa thickening in atopic patients had a significant difference compared with that in non-atopic patients (p=0.028). In severe asthmatics, the opacification degree of maxillary sinuses was significantly more prominent compared with those in moderate and mild asthmatics (p=0.0005, p=0.036, respectively). Significantly marked nasal mucosa thickening was recognized in mild asthmatics compared with that in moderate asthmatics (p=0.0462). Regarding bronchial hyperresponsiveness, a significant correlation between Dmin and the opacification degree of maxillary sinuses was observed (rs= -0.551, p=0.0276). Nasal mucosa thickening had no correlation with bronchial hyperresponsiveness. The results suggest that sinusitis may affect bronchial hyperresponsiveness and asthma severity. Treatment of sinusitis may lead to improvement of asthma symptoms.
キーワード	気管支喘息 (bronchial asthma) 副鼻腔炎 (sinusitis) CT所見 (CT findings) 気道過敏性 (hyperresponsiveness)
出版物タイトル	岡大三朝分院研究報告
発行日	1999-12
巻	70巻
開始ページ	28
終了ページ	35
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308098

Evaluation of low attenliation area (LAA) of the lungs in patients with reversible airway obstruction by high resolution computed tomography (HRCT).

JaLCDOI	10.18926/14925
タイトル（別表記）	気管支喘息における胸部HRCT所見の臨床[光延文裕1]的意義
フルテキストURL	070_017_027.pdf
著者	光延文裕\| 御舩尚志\| 芦田耕三\| 保崎泰弘\| 柘野浩史\| 岡本誠\| 原田誠之\| 中井陸郎\| 谷崎勝朗\|
抄録	The significance of the low attenuation area (LAA) of the lungs on high resolution computed tomography (HRCT) has not been determined in patients with asthma. We examined the relationship between the percentage of lung area with CT numbers lower than -950HU (% LAA) and the mean CT number in 81 patients with reversible airway obstruction (asthma) and in 22 healthy subjects, as well as the relationship between maximal % LAA and various parameters of pulmonary function, smoking history, disease severity and allergic type in the asthmatic subjects. The mean CT number was obtained by scans at three anatomic levels, and maximal % LAA was the % LAA which had the largest value of those measured at the three anatomic levels of the lung. We found that: 1. The mean CT number was closely related to the maximal % LAA of the lungs in all subjects studied (r= -0.916, p
キーワード	low attenuation area high resolution computed tomography reversible airway obstruction
出版物タイトル	岡大三朝分院研究報告
発行日	1999-12
巻	70巻
開始ページ	17
終了ページ	27
ISSN	0918-7839
言語	英語
論文のバージョン	publisher
NAID	120002308175