検索結果 1505 件
| JaLCDOI | 10.18926/AMO/60374 |
|---|---|
| フルテキストURL | 74_4_351.pdf |
| 著者 | Utsumi, Masashi| Aoki, Hideki| Yabuki, Takayuki| Nagahisa, Seiichi| Nishimura, Seitaro| Une, Yuta| Kimura, Yuji| Watanabe, Megumi| Taniguchi, Fumitaka| Arataa, Takashi| Katsuda, Koh| Tanakaya, Kohji| Sato, Yumiko| |
| 抄録 | Post-operative pancreatic fistula (POPF) remains the most common complication after distal pancreatectomy (DP). In this retrospective study, we reviewed the data from patients who underwent DP between 2008 and 2019 in our institute to determine whether the late phase/early phase ratio (L/E ratio) by preoperative computed tomography (CT) scan in the pancreas could predict POPF occurrence after DP. We examined the relationship between preoperative or intraoperative factors and the occurrence of POPF after DP using statistical methods in 23 males and 21 females with a mean age of 73. The mean L/E ratio was significantly lower in the POPF group than the non-POPF group (p=0.035). The L/E ratio had moderate diagnostic accuracy, with a calculated optimal cutoff value of 0.77. In univariate analysis, a significant association was noted between POPF and stump thickness ≥ 16.9, body mass index ≥ 27.5, and L/E ratio ≤ 0.77. In the multivariate analysis, the L/E ratio (odds ratio, 5.96; p=0.036) was an independent risk factor for POPF. Our findings suggest that the pancreatic L/E ratio may predict the occurrence of POPF after DP. This measure may be useful in preoperative risk stratification, patient counseling, and perioperative patient management, improving clinical outcomes after DP. |
| キーワード | late phase/early phase ratio pancreatic fistula distal pancreatectomy |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-08 |
| 巻 | 74巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 351 |
| 終了ページ | 358 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32843767 |
| Web of Science KeyUT | 000562508700011 |
| NAID | 120006880213 |
| JaLCDOI | 10.18926/AMO/60372 |
|---|---|
| フルテキストURL | 74_4_335.pdf |
| 著者 | Yamamoto, Yumiko| Hayashi, Yoshihiro| Murakami, Ichiro| |
| 抄録 | Since the discovery of the NAB2-STAT6 gene fusion in 2013, solitary fibrous tumor (SFT) and hemangiopericytoma (HPC) have been considered the same disease. STAT6 nuclear stain is approved as a highly sensitive and specific marker to diagnose SFT/HPC from other tumors with similar histology. As the next step, detection of fusion variants that may predict clinical malignancy of SFT/HPC has been attempted. However, no fusion variants with a clear relation to malignancy have been identified. In this study, the clinical and histological backgrounds of 23 Japanese patients diagnosed with SFT/HPC from 2000 to 2019 at Kochi University Hospital were examined to identify factors potentially related to recurrence. A significant relationship to recurrence was detected for mitosis ≥ 1/10 HPF (400×), necrosis, and Ki-67>5%. These findings indicate that a deliberate investigation of histological features such as mitosis and necrosis is crucial for the clinical observation of SFT/ HPC patients. In addition, Ki-67 was revealed to be a useful parameter to predict recurrence in SFT/HPC patients. |
| キーワード | solitary fibrous tumor hemangiopericytoma Ki-67 NAB2-STAT6 WHO classification WHO grading criteria Marseille Grading System |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-08 |
| 巻 | 74巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 335 |
| 終了ページ | 343 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32843765 |
| Web of Science KeyUT | 000562508700009 |
| NAID | 120006880211 |
| JaLCDOI | 10.18926/AMO/60370 |
|---|---|
| フルテキストURL | 74_4_319.pdf |
| 著者 | Isoyama, Satoshi| Kimura, Satoshi| Morimatsu, Hiroshi| |
| 抄録 | Little is known about the role of a strong ions in humans with respiratory abnormalities. In this study, we investigated the associations between partial carbon dioxide pressure (pCO2) and each of sodium ion (Na+) concentrations, chloride ion (Cl−) concentrations and their difference (SIDNa-Cl). Blood gas data were obtained from patients in a teaching hospital intensive care unit between August 2013 and January 2017. The association between pCO2 and SIDNa-Cl was defined as the primary outcome. The associations between pCO2 and [Cl−], [Na+] and other strong ions were secondary outcomes. pCO2 was stratified into 10 mmHg-wide bands and treated as a categorical variable for comparison. As a result, we reviewed 115,936 blood gas data points from 3,840 different ICU stays. There were significant differences in SIDNa-Cl, [Cl−], and [Na+] among all categorized pCO2 bands. The respective pCO2 SIDNa-Cl, [Cl−], and [Na+] correlation coefficients were 0.48, −0.31, and 0.08. SIDNa-Cl increased and [Cl−] decreased with pCO2, with little relationship between pCO2 and [Na+] across subsets. In conclusion, we found relatively strong correlations between pCO2 and SIDNa-Cl in the multiple blood gas datasets examined. Correlations between pCO2 and chloride concentrations, but not sodium concentrations, were further found to be moderate in these ICU data. |
| キーワード | acid-base phenomena Stewart approach strong ion difference chlorine ion partial carbon dioxide pressure |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-08 |
| 巻 | 74巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 319 |
| 終了ページ | 325 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32843763 |
| Web of Science KeyUT | 000562508700007 |
| NAID | 120006880209 |
| JaLCDOI | 10.18926/AMO/60369 |
|---|---|
| フルテキストURL | 74_4_307.pdf |
| 著者 | Nagamine, Yuichi| Hasibul, Khaleque| Ogawa, Takaaki| Tada, Ayano| Kamitori, Kazuyo| Hossain, Akram| Yamaguchi, Fuminori| Tokuda, Masaaki| Kuwahara, Tomomi| Miyake, Minoru| |
| 抄録 | We examined the effect of D-Tagatose on the growth of oral bacteria including Streptococcus mutans (S. mutans). Saliva collected from 10 healthy volunteers was plated on BHI medium (to culture total oral bacteria) and MBS medium (to culture S. mutans, specifically). Agar plates of BHI or MBS containing xylitol or D-Tagatose were cultured under aerobic or anaerobic conditions. We then counted the number of colonies. In BHI plates containing D-Tagatose, a complete and significant reduction of bacteria occurred under both aerobic and anaerobic conditions. In MSB medium, significant reduction of S. mutans was also observed. We then performed a doubleblind parallel randomized trial with 19 healthy volunteers. They chewed gum containing xylitol, D-Tagatose, or both for 4 weeks, and their saliva was collected weekly and plated on BHI and MSB media. These plates were cultured under anaerobic conditions. Total bacteria and S. mutans were not effectively reduced in either the D-Tagatose or xylitol gum group. However, S. mutans was significantly reduced in volunteers chewing gum containing both D-Tagatose and xylitol. Thus, D-Tagatose inhibited the growth of S. mutans and many types of oral bacteria, indicating that D-Tagatose intake may help prevent dental caries, periodontitis, and many oral diseases. |
| キーワード | D-Tagatose xylitol Streptococcus mutans oral bacteria chewing gum |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-08 |
| 巻 | 74巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 307 |
| 終了ページ | 317 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32843762 |
| Web of Science KeyUT | 000562508700006 |
| NAID | 120006880208 |
| JaLCDOI | 10.18926/AMO/60368 |
|---|---|
| フルテキストURL | 74_4_301.pdf |
| 著者 | Takahashi, Kei| Kitamura, Yoshihisa| Ushio, Soichiro| Sendo, Toshiaki| |
| 抄録 | Ketamine has been clinically proven to ameliorate depression, including treatment-resistant depression. The detailed mechanism of action of ketamine in treatment-resistant depression remains unclear. We examined the effects of ketamine on the immobility times of adrenocorticotropic hormone (ACTH)-treated rats during the forced swim test, and we explored the mechanism by which ketamine acts in this model. We investigated the neuroanatomical site of action by microinjecting ketamine into the medial prefrontal cortex of rats. A significant reduction of the rats’ immobility during the forced swim test was observed after the intraperitoneal injection of ketamine in both saline- and ACTH-treated rats. The microinjection of ketamine into the medial prefrontal cortex also decreased immobility during the forced swim test in both saline- and ACTH-treated rats. The immobility-decreasing effect of intraperitoneally injected ketamine was blocked by administering WAY100635, a 5-HT1A receptor antagonist, into the medial prefrontal cortex. These findings contribute to the evidence that ketamine can be useful against treatment-resistant depressive conditions. The immobility-reducing effects of ketamine might be mediated by 5-HT1A receptor activity in the medial prefrontal cortex. |
| キーワード | ketamine adrenocorticotropic hormone forced swim test medial prefrontal cortex 5-HT1A receptor |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-08 |
| 巻 | 74巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 301 |
| 終了ページ | 306 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32843761 |
| Web of Science KeyUT | 000562508700005 |
| NAID | 120006880207 |
| JaLCDOI | 10.18926/AMO/60367 |
|---|---|
| フルテキストURL | 74_4_293.pdf |
| 著者 | Yoshioka, Takashi| Omae, Kenji| Kawada, Tatsushi| Inoue, Yosuke| Sugimoto, Morito| Oeda, Tadashi| Uehara, Shinya| Araki, Motoo| Fukuhara, Shunichi| |
| 抄録 | In this retrospective single-center cohort study, we investigated the impact of preoperative use of an alpha-1 adrenergic receptor (AR) blocker on the outcome of single-session extracorporeal shock wave lithotripsy (SWL) in 193 male patients who underwent SWL for a single ureteral calculus between 2006 and 2016. We reviewed their medical records to obtain the data on the preoperative use of alpha-1 AR blockers. The primary outcome was treatment success after single-session SWL. We performed a multivariable logistic regression analysis adjusting for clinically important confounders to examine the association between preoperative use of alpha-1 AR blockers and the treatment success of SWL. Among the 193 patients, 15 (7.8%) were taking an alpha-1 AR blocker preoperatively. A multivariable analysis showed that preoperative use of an alpha-1 AR blocker was a significant negative predictor for treatment success of SWL (adjusted odds ratio 0.17; 95% confidence intervals, 0.04-0.74). Our findings suggest that the preoperative use of an alpha-1 AR blocker was a negative predictor of treatment success of SWL in male patients with a single ureteral calculus. Clinicians should pay more attention to the preoperative drug use in determining an appropriate stone therapy modality. |
| キーワード | urolithiasis extracorporeal shockwave therapy adrenergic alpha-1 receptor antagonists |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-08 |
| 巻 | 74巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 293 |
| 終了ページ | 299 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32843760 |
| Web of Science KeyUT | 000562508700004 |
| NAID | 120006880206 |
| JaLCDOI | 10.18926/AMO/60364 |
|---|---|
| フルテキストURL | 74_4_275.pdf |
| 著者 | Muro, Taiko| Nakamura, Shinichiro| Takaki, Akinobu| Onishi, Hideki| Wada, Nozomu| Yasunaka, Tetsuya| Uchida, Daisuke| Oyama, Atsushi| Adachi, Takuya| Shiraha, Hidenori| Okada, Hiroyuki| |
| 抄録 | Radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) is a promising method for controlling tumors, although it does not entirely eliminate recurrence. Oxidative stress is associated with the progression of hepatocarcinogenesis, while also acting as an anticancer response. The objective of the present study was to investigate the factors influencing post-RFA outcomes. We recruited 235 newly diagnosed HCC patients who received RFA for single tumors. The patients with recurrence were sub-grouped into early and segmental recurrence groups. The characteristics of the sub-grouped patients were evaluated, including by measuring oxidative stress marker reactive oxygen metabolites and antioxidant marker OXY-adsorbent tests. The factors associated with poor survival were a high Child-Pugh score and early recurrence within 2 years in the same segment. The patients who experienced recurrence within 2 years in the same segment showed a larger tumor diameter than did others. According to a multivariate analysis, the OXY values were also significantly low in these patients. In conclusion, maintaining the antioxidant reservoir function with a high OXY value might be necessary to prevent early recurrence within the RFA-treated segment. |
| キーワード | oxidative stress hepatocellular carcinoma recurrence, radiofrequency ablation |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-08 |
| 巻 | 74巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 275 |
| 終了ページ | 283 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32843758 |
| Web of Science KeyUT | 000562508700002 |
| NAID | 120006880203 |
| JaLCDOI | 10.18926/AMO/60363 |
|---|---|
| フルテキストURL | 74_4_265.pdf |
| 著者 | Inokuchi, Toshihiro| Hiraoka, Sakiko| Yasutomi, Eriko| Oka, Shohei| Yamasaki, Yasushi| Kinugasa, Hideaki| Takahar, Masahiro| Kawano, Seiji| Harada, Keita| Okada, Hiroyuki| Kato, Jun| |
| 抄録 | Determining factors that predict a favorable disease course without anti-tumor necrosis factor (TNF) agents would help establish a more cost-effective strategy for Crohn’s disease (CD). A retrospective chart review was performed for CD patients with disease durations > 10 years who had not received anti-TNF agents as first-line therapy. Patients were divided into 2 groups: those who received neither anti-TNF agents nor bowel resection (G1), and those who had received an anti-TNF agent and/or bowel resection (G2). The patient backgrounds, therapies and clinical courses were compared between the groups. A total of 62 CD patients met the inclusion criteria (males: 71%; median duration of follow-up: 19 years). Six patients were included in G1; they were significantly less likely to have upper gastrointestinal lesions than G2 (p=0.007). A multivariate analysis revealed that the significant factors for avoidance of bowel resection without anti-TNF treatment were non-stricturing and non-penetrating behaviors, and absence of upper gastrointestinal lesions at the diagnosis (hazard ratios 0.41 and 0.52; p=0.004 and 0.04, respectively). In consideration of the long treatment course of CD, patients with non-stricturing and non-penetrating behaviors and no upper gastrointestinal lesions should not be treated with anti-TNF agents as first-line therapy. |
| キーワード | Crohn’s disease anti-TNF agent upper gastrointestinal lesion bamboo joint-like appearance |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-08 |
| 巻 | 74巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 265 |
| 終了ページ | 274 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32843757 |
| Web of Science KeyUT | 000562508700001 |
| NAID | 120006880202 |
| タイトル（別表記） | Peritonsillar abscess with otorrhea |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | 大道 亮太郎| 片岡 祐子| 石原 久司| 西﨑 和則| |
| 発行日 | 2013-05 |
| 出版物タイトル | 日本耳鼻咽喉科感染症研究会会誌 |
| 巻 | 31巻 |
| 号 | 1号 |
| 出版者 | 日本耳鼻咽喉科感染症研究会 |
| 開始ページ | 175 |
| 終了ページ | 178 |
| ISSN | 09133976 |
| NCID | AN10042649 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 日本語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | ©日本耳鼻咽喉科感染症研究会 |
| 論文のバージョン | publisher |
| オフィシャル URL | http://www.jsiao.umin.jp/infect-archive/number/42.html| |
| フルテキストURL | RSC_Adv_4_10_fulltext.pdf |
|---|---|
| 著者 | Watanabe, Takaichi| Kimura, Yukitaka| Ono, Tsutomu| |
| 発行日 | 2013-12-10 |
| 出版物タイトル | RSC Advances |
| 巻 | 4巻 |
| 号 | 10号 |
| 出版者 | Royal Society of Chemistry |
| 開始ページ | 4872 |
| 終了ページ | 4877 |
| ISSN | 2046-2069 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | publisher |
| DOI | 10.1039/C3RA44066D |
| Web of Science KeyUT | 000329254100013 |
| 関連URL | isVersionOf https://doi.org/10.1039/C3RA44066D |
| フルテキストURL | Langmuir_29_fulltext.pdf |
|---|---|
| 著者 | Watanabe, Takaichi| Kimura, Yukitaka| Ono, Tsutomu| |
| 備考 | “This document is the Accepted Manuscript version of a Published Work that appeared in final form in Langmuir, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/la403883a.”| |
| 発行日 | 2013-10-29 |
| 出版物タイトル | Langmuir |
| 巻 | 29巻 |
| 号 | 46号 |
| 出版者 | American Chemical Society |
| 開始ページ | 14082 |
| 終了ページ | 14088 |
| ISSN | 0743-7463 |
| NCID | AA10461730 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | author |
| PubMed ID | 24164350 |
| DOI | 10.1021/la403883a |
| Web of Science KeyUT | 000330144100012 |
| 関連URL | isVersionOf https://doi.org/10.1021/la403883a |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Uchida-Fukuhara, Yoko| Ekuni, Daisuke| Islam, Md Monirul| Kataoka, Kota| Taniguchi-Tabata, Ayano| Fukuhara, Daiki| Toyama, Naoki | Kobayashi, Terumasa| Fujimori, Kohei| Sawada, Nanami| Iwasaki, Yoshiaki| Morita, Manabu| |
| キーワード | salivary microbiome sequence analysis young adult dental caries saliva oral health |
| 発行日 | 2020-05-25 |
| 出版物タイトル | International Journal of Environmental Research and Public Health |
| 巻 | 17巻 |
| 号 | 10号 |
| 出版者 | MDPI |
| 開始ページ | 3713 |
| ISSN | 1660-4601 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2020 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 32466124 |
| DOI | 10.3390/ijerph17103713 |
| Web of Science KeyUT | 000539300900370 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijerph17103713 |
| JaLCDOI | 10.18926/okadaironkou/60037 |
|---|---|
| フルテキストURL | okadaironkou_41_48_39.pdf |
| 著者 | 京 健治| |
| 出版物タイトル | 岡大国文論稿 |
| 発行日 | 2013-03-31 |
| 号 | 41号 |
| 開始ページ | 48 |
| 終了ページ | 39 |
| ISSN | 0386-3123 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 40019753077 |
| JaLCDOI | 10.18926/okadaironkou/60036 |
|---|---|
| フルテキストURL | okadaironkou_41_38_30.pdf |
| 著者 | 張 照旭| |
| 出版物タイトル | 岡大国文論稿 |
| 発行日 | 2013-03-31 |
| 号 | 41号 |
| 開始ページ | 38 |
| 終了ページ | 30 |
| ISSN | 0386-3123 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 40019753074 |
| JaLCDOI | 10.18926/okadaironkou/60035 |
|---|---|
| フルテキストURL | okadaironkou_41_15_29.pdf |
| 著者 | 西山 康一| 庄司 達也| |
| 出版物タイトル | 岡大国文論稿 |
| 発行日 | 2013-03-31 |
| 号 | 41号 |
| 開始ページ | 15 |
| 終了ページ | 29 |
| ISSN | 0386-3123 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 40019753070 |
| JaLCDOI | 10.18926/okadaironkou/60034 |
|---|---|
| フルテキストURL | okadaironkou_41_1_14.pdf |
| 著者 | 渡辺 健| |
| 出版物タイトル | 岡大国文論稿 |
| 発行日 | 2013-03-31 |
| 号 | 41号 |
| 開始ページ | 1 |
| 終了ページ | 14 |
| ISSN | 0386-3123 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 40019753066 |
| JaLCDOI | 10.18926/AMO/59961 |
|---|---|
| フルテキストURL | 74_3_261.pdf |
| 著者 | Nakahara, Keiichi| Ikeda, Tokunori| Takamatsu, Koutaro| Tawara, Nozomu| Hara, Kentaro| Enokida, Yuki| Tanoue, Naomi| Narita, Sawana| Fujii, Akiko| Yamanouchi, Yoshinori| Morinaga, Jun| Yamashita, Satoshi| |
| 抄録 | Muscle biopsy can be used to confirm the diagnosis of neuromuscular diseases. However, it is unclear whether antibiotic prophylaxis prior to muscle biopsy is needed to prevent surgical site infection (SSI). We are conducting a phase 2, single-center, open-labeled, prospective randomized trial to clarify the need for antibiotic prophylaxis in patients at low risk for SSI undergoing muscle biopsy. Patients will be randomized to an antibiotic prophylaxis group or a control group, and the incidence of SSI will be compared between the groups. Our findings will clarify the need for antibiotic prophylaxis in this patient population. |
| キーワード | muscle biopsy antibiotic prophylaxis |
| Amo Type | Clinical Study Protocol |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-06 |
| 巻 | 74巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 261 |
| 終了ページ | 264 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32577026 |
| Web of Science KeyUT | 000543363400011 |
| NAID | 120006862802 |
| JaLCDOI | 10.18926/AMO/59956 |
|---|---|
| フルテキストURL | 74_3_229.pdf |
| 著者 | Shibata, Kiyo| Hamasaki, Ichiro| Toshima, Shinji| Shimizu, Takehiro| Kono, Reika| Miyata, Manabu| Morisawa, Shin| Furuse, Takashi| Hasebe, Satoshi| Ohtsuki, Hiroshi| Morizane, Yuki| Shiraga, Fumio| |
| 抄録 | The purpose of this study was to derive new formulas to provide an optimal surgical procedure and optimal amount of recession-resection (RR) surgery in intermittent exotropia (IXT) with a disparity in angle of deviation depending on the fixation distance. The records of 117 consecutive patients with IXT who underwent RR surgery between March 2008 and December 2011 at Okayama University Hospital were retrospectively examined. Multivariable linear regression analysis was performed using the observed corrective angle of deviation at distance or near fixation as the dependent variable, and amounts of lateral rectus muscle (LR) recession (mm) and medial rectus muscle (MR) resection, and age at surgery (years) as independent variables. Two simultaneous formulas were derived: corrective angle of deviation at distance fixation (°)=1.8×recession (mm)+1.6× resection (mm)+0.15×age (years)–6.6, and corrective angle at near fixation (°)=1.5×recession (mm)+1.7× resection (mm)+0.18×age (years)–3.8. Comparisons of coefficient values of the formulas between distance and near fixation revealed that LR recession was more affected by the corrective angle in distance than near fixation. MR resection was more affected at near than distance fixation. We found that our new formulas estimated the appropriate amount of unilateral RR surgery. |
| キーワード | surgical amount intermittent exotropia recession and resection procedure strabismus surgery recurrent exotropia |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-06 |
| 巻 | 74巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 229 |
| 終了ページ | 236 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32577021 |
| JaLCDOI | 10.18926/AMO/59954 |
|---|---|
| フルテキストURL | 74_3_221.pdf |
| 著者 | Yagura, Takuma| Oe, Kenichi| Paku, Masaaki| Tajima, Takeshi| Nakamura, Masaya| Iida, Hirokazu| Saito, Takanori| |
| 抄録 | We retrospectively evaluated the cases of 169 hip fracture patients, their previous fractures, and the contralateral hip joint’s morphology. A history of contralateral hip fracture was present in 23 patients (Contra group). The other patients had a unilateral hip fracture: a trochanteric fracture (Troch group, n=73) or a femoral neck fracture (Neck group, n=73). In the Troch and Neck groups, we used anteroposterior and cross-table axialview radiographs of the contralateral hip to evaluate the proximal femur’s anatomy. In the Contra group, the concordance rate between the first and second types of hip fracture was 65.2%, and the second hip fracture’s morphology indicated that the trochanteric fracture had a cam deformity in terms of the femoral head-neck ratio. The average alpha angle and femoral head-neck offset in the Troch group were significantly larger than those in the Neck group. In the Neck group, pistol-grip deformities of Arbeitsgemeinschaft für Osteosynthesefragen types B1 (subcapital), B2 (transcervical), and B3 (displaced) were observed in 42.1%, 75%, and 6% of cases, respectively. There was a smaller alpha angle and a larger femoral head-neck offset in the contralateral hip of femoral neck fractures; thus, the “cam deformity” may protect against femoral neck fractures. |
| キーワード | cam deformity femoral neck fracture trochanteric fracture bilateral hip fractures |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-06 |
| 巻 | 74巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 221 |
| 終了ページ | 227 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32577020 |
| Web of Science KeyUT | 000543363400006 |
| NAID | 120006862796 |
| JaLCDOI | 10.18926/AMO/59950 |
|---|---|
| フルテキストURL | 74_3_199.pdf |
| 著者 | Fujita, Hirofumi| Bando, Tetsuya| Oyadomari, Seiichi| Ochiai, Kazuhiko| Watanabe, Masami| Kumon, Hiromi| Ohuchi, Hideyo| |
| 抄録 | Dickkopf 3 (Dkk3) is a secreted protein belonging to the Dkk family and encoded by the orthologous gene of REIC. Dkk3/REIC is expressed by mouse and human adrenal glands, but the understanding of its roles in this organ is still limited. To determine the functions of Dkk3 in the mouse adrenal gland, we first identified that the mouse Dkk3 protein is N-glycosylated in the adrenal gland as well as in the brain. We performed proteome analysis on adrenal glands from Dkk3-null mice, in which exons 5 and 6 of the Dkk3 gene are deleted. Twodimensional polyacrylamide gel electrophoresis of adrenal proteins from wild-type and Dkk3-null mice revealed 5 protein spots whose intensities were altered between the 2 genotypes. Mass spectrometry analysis of these spots identified binding immunoglobulin protein (BiP), an endoplasmic reticulum (ER) chaperone. To determine whether mouse Dkk3 is involved in the unfolded protein response (UPR), we carried out a reporter assay using ER-stress responsive elements. Forced expression of Dkk3 resulted in the induction of distinct levels of reporter expression, showing the UPR initiated by the ER membrane proteins of activating transcription factor 6 (ATF6) and inositol-requring enzyme 1 (IRE1). Thus, it is possible that Dkk3 is a physiological ER stressor in the mouse adrenal gland. |
| キーワード | Dkk3 knockout mouse adrenal gland glucose-regulated protein 78 proteome endoplasmic reticulum stress |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2020-06 |
| 巻 | 74巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 199 |
| 終了ページ | 208 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2020 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 32577017 |
| Web of Science KeyUT | 000543363400003 |
| NAID | 120006862792 |