検索結果 8466 件
| JaLCDOI | 10.18926/AMO/55203 |
|---|---|
| フルテキストURL | 71_3_209.pdf |
| 著者 | Xin, Zhao| Tsuda, Toshihide| Doi, Hiroyuki| |
| 抄録 | We evaluated how exposure to airborne volatile organic compounds emitted from a plastic recycling facility affected nearby residents, in a cross-sectional study. Individuals>10 years old were randomly sampled from 50 households at five sites and given questionnaires to complete. We categorized the subjects by distance from the recycling facility and used this as a proxy measure for pollutant exposure. We sought to improve on a preceding study by generating new findings, improving methods for questionnaire distribution and collection, and refining site selection. We calculated the odds of residents living 500 or 900 m away from the facility reporting mucocutaneous and respiratory symptoms using a reference group of residents 2,800 m away. Self-reported nasal congestion (odds ratio=3.0, 95% confidence interval=1.02-8.8), eczema (5.1, 1.1-22.9), and sore throat (3.9, 1.1-14.1) were significantly higher among residents 500 m from the facility. Those 900 m away were also considerably more likely to report experiencing eczema (4.6, 1.4-14.9). Air pollution was found responsible for significantly increased reports of mucocutaneous and respiratory symptoms among nearby residents. Our findings confirm the effects of pollutants emitted from recycling facilities on residents’ health and clarify that study design differences did not affect the results. |
| キーワード | air pollutants volatile organic compounds recycling facility mucocutaneous symptoms respiratory symptoms |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-06 |
| 巻 | 71巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 209 |
| 終了ページ | 217 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28655940 |
| JaLCDOI | 10.18926/AMO/55202 |
|---|---|
| フルテキストURL | 71_3_201.pdf |
| 著者 | Matsuda, Miwa| Sasaki, Aiko| Shimizu, Keiko| Kamada, Yasuhiko| Noguchi, Soichi| Hiramatsu, Yuji| Nakatsuka, Mikiya| |
| 抄録 | Vascular dysfunction has been reported in women with recurrent pregnancy loss (RPL). We investigated the severity of vascular dysfunction in non-pregnant women with RPL and its correlation with anti-heat shock protein (HSP) antibodies that are known to induce arteriosclerosis. We measured the serum anti-HSP60 antibodies, anti-HSP70 antibodies, and anti-phospholipid antibodies (APA) in 68 women with RPL and 29 healthy controls. Among the women with RPL, 14 had a diagnosis of antiphospholipid syndrome (APS), and in the remaining 54, the causes for RPL were unexplained. Compared to the controls, the brachial-ankle pulse wave velocity (baPWV), carotid augmentation index (cAI), and uterine artery pulsatility index (PI) were all significantly higher in the women with both APS and unexplained RPL. Compared to the controls, the anti-HSP60 antibody levels were significantly higher in the APA-positive group of women with unexplained RPL, and the anti-HSP70 antibody levels were significantly higher in APS and APA-positive group of women with unexplained RPL. However, the anti-HSP60 and anti-HSP70 antibody levels did not correlate with the values of baPWV or cAI. Our results demonstrated anti-HSP60 and anti-HSP70 antibodies are increased in women with unexplained RPL. Further studies are needed to elucidate the roles of anti-HSP antibodies and their pathophysiology in unexplained RPL. |
| キーワード | recurrent pregnancy loss autoantibody heat shock protein pulse wave velocity arterial stiffness |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2017-06 |
| 巻 | 71巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 201 |
| 終了ページ | 208 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2017 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 28655939 |
| フルテキストURL | K0005453_other1.pdf |
|---|---|
| 著者 | Nobumoto, Etsuko| Masuyama, Hisashi| Hiramatsu, Yuji| Sugiyama, Takashi| Kusaka, Hideto| Toyoda, Nagayasu| |
| キーワード | New GDM criteria Perinatal complications Obesity 75-g oral glucose tolerance test |
| 備考 | The final publication is available at Springer| 学位審査副論文| |
| 発行日 | 2015-09 |
| 出版物タイトル | Diabetology International |
| 巻 | 6巻 |
| 号 | 3号 |
| 出版者 | Springer Japan |
| 開始ページ | 226 |
| 終了ページ | 231 |
| ISSN | 21901678 |
| NCID | AA12503387 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| 論文のバージョン | author |
| DOI | 10.1007/s13340-014-0193-8 |
| Web of Science KeyUT | 000366631000009 |
| 関連URL | http://doi.org/10.1007/s13340-014-0193-8 http://ousar.lib.okayama-u.ac.jp/55005 |
| タイトル（別表記） | Identification of Marker Gene of Pars Tuberalis Morphogenesis in Chicken Embryo. The expression of Cytokine-like 1 and Gap junction protein alpha 5 in the pars tuberalis |
|---|---|
| フルテキストURL | poalas_033_031_034.pdf |
| 著者 | 相澤 清香| 檜垣 佑理子| 御輿 真穂| 竹内 栄| 高橋 純夫| |
| 抄録 | Adenohypophysis delivered from oral ectoderm consists of pars distalis (PD), pars intermedia and pars tuberalis (PT). The mechanisms of development of PD has been well studied, and the cell differentiation of PD has been well understood. However, the morphogenesis and the differentiation of PT are still unclear, and the gene expression during the PT development remains largely unknown. In this study, we explored the specifically expressing genes in PT during development and analyzed its spatiotemporal expressions pattern. Microarray analysis on laser-captured PT and PD tissues obtained from chicken embryos on embryonic day 10 (E10.0) showed high expressing genes, Cytokine-like 1 (CYTL1) and Gap junction protein alpha 5 (GJA5) in PT. A detail analysis of spatiotemporal expressions pattern during chick embryo development by in situ hybridization revealed that CYTL1 mRNA was first detected in lateral head ectoderm and ventral head ectoderm in E1.5. The CYTL1 expressions moved into Rathke’s pouch at E2.5, then it was localized in PT primordium and continuously expressed in PT primordium until E12.0. On the other hand, GJA5 mRNA was transiently detected in PT primordium from E6 to E14.0, while the expression was not detected in PD during development. These results suggested that these genes may be involved in the regulation mechanism of PT development and could be a useful marker in the PT development. |
| 出版物タイトル | 岡山実験動物研究会報 |
| 発行日 | 2017-04 |
| 巻 | 33巻 |
| 開始ページ | 31 |
| 終了ページ | 34 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| タイトル（別表記） | Structure and function of tegmentum vasculosum in avian cochlea |
|---|---|
| フルテキストURL | poalas_033_026_030.pdf |
| 著者 | 池田 理佐| 乙野 剛史| 池田 直矢| 齋藤 昇| 安藤 元紀| |
| 抄録 | In spite of the importance of endocochlear DC potential (EP) and the K+-rich endolymph for the avian cochlea, the structure and function of the tegmentum vasculosum (TV) has not yet been fully elucidated, compared with those of the stria vascularis in the mammalian cochlea. In this study, we examined structural analysis of the epithelial cells, gene expressions of Na+-K+-ATPase (Atp1A1) and Kir4.1 (Kcnj10), and protein localizations of Na+-K+-ATPase and Kir4.1, in the TV. Tight junctional structures were observed between epithelial dark cells and light cells in the TV. Both Atp1a1 and Kcnj10 genes were detected in the TV. In addition, immunopositive signals for both Na+-K+-ATPase and Kir4.1 were recognized in the TV. These results indicate that Na+-K+-ATPase and Kir4.1 play roles in maintaining the EP and high K+ concentration of the endolymph. Further studies are needed to clarify the physiological functions of the TV. This is the first report which demonstrates that gene and protein expression data contribute to the avian inner ear homeostasis. |
| 出版物タイトル | 岡山実験動物研究会報 |
| 発行日 | 2017-04 |
| 巻 | 33巻 |
| 開始ページ | 26 |
| 終了ページ | 30 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| タイトル（別表記） | Dissecting the hierarchy and lineage of mesenchymal stem cells by mouse genetics |
|---|---|
| フルテキストURL | poalas_033_015_017.pdf |
| 著者 | 宝田 剛志| |
| 抄録 | Determination of stem cell hierarchy/lineage is indispensable for a better understanding and augmentation of many aspects of medical sciences, including the mechanisms of tissue development and maintenance of tissue homeostasis, as well as disease development. It also has implications in the field of tissue regeneration for medical treatments and disease modeling for drug discovery using iPS technology. Mesenchymal stem cells are multipotent stem cell that can differentiate into various type of cells including osteoblasts, adipocytes, myocytes and chondrocytes. Runt-related transcription factor 2 (Runx2) is an essential transcriptional regulator of osteoblast differentiation. Runx2 deficiency in Prx1+-derived cells (Runx2prx1−/− mice) resulted in defective intramembranous ossification. Double-positive cells for Prx1-GFP and stem cell antigen-1 (Sca1) (Prx1+Sca1+ cells) in the calvaria expressed Runx2 at lower levels and were more homogeneous and primitive as compared with Prx1+Sca1− cells. Our results suggest that osteoblast differentiation in vivo may begin at the Prx1+Sca1+ MSC stage with sequential progression to Prx1+Sca1−cells, then Osx+Prx1−Sca1− osteoblast precursors, which eventually form mature α1(I)-collagen+ osteoblasts. |
| 出版物タイトル | 岡山実験動物研究会報 |
| 発行日 | 2017-04 |
| 巻 | 33巻 |
| 開始ページ | 15 |
| 終了ページ | 17 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| タイトル（別表記） | Contribution and progress of the gnotobiote technology in gut microbiome research |
|---|---|
| フルテキストURL | poalas_033_011_014.pdf |
| 著者 | 森田 英利| |
| 出版物タイトル | 岡山実験動物研究会報 |
| 発行日 | 2017-04 |
| 巻 | 33巻 |
| 開始ページ | 11 |
| 終了ページ | 14 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| タイトル（別表記） | A greeting from President of Okayama Association for Laboratory Animal Science |
|---|---|
| フルテキストURL | poalas_033_001.pdf |
| 著者 | 国枝 哲夫| |
| 出版物タイトル | 岡山実験動物研究会報 |
| 発行日 | 2017-04 |
| 巻 | 33巻 |
| 開始ページ | 1 |
| 終了ページ | 1 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| 著者 | Kondo, Mariko| Mori, Kazuo| Nomura, Hiroshi| Kadowaki, Hanako| Watanabe, Makiko| Doi, Akemi| Shima, Sayaka| |
|---|---|
| 発行日 | 2016-12-29 |
| 出版物タイトル | Bioethics - Medical, Ethical and Legal Perspectives |
| 資料タイプ | 図書 |
| フルテキストURL | iriseki_032.pdf iriseki_032_image.pdf |
|---|---|
| 著者 | 山本 悦世| 南 健太郎| 岩崎 志保| 山口 雄治| 高椋 浩史| 能城 修一| 白石 純| 沖 陽子| 江川 達也| 大久保 雅子| |
| 出版物タイトル | 岡山大学構内遺跡発掘調査報告 |
| 発行日 | 2017-03-21 |
| 巻 | 32巻 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| Pages | 249p. 47図版 |
| タイトル（別表記） | Bulletin of Archaeological Research Center Okayama University 2015 |
|---|---|
| フルテキストURL | barc_2015.pdf |
| 著者 | 南 健太郎| 山口 雄治| 福田 宏| 野崎 貴博| |
| 出版物タイトル | 岡山大学埋蔵文化財調査研究センター紀要 |
| 発行日 | 2017-03-10 |
| 巻 | 2015巻 |
| 言語 | 日本語 |
| 著作権者 | Archaeological Research Center, Okayama University |
| 論文のバージョン | publisher |
| Pages | v, 84 p. |
| フルテキストURL | erc_038_backcover.pdf |
|---|---|
| 著者 | 岡山大学環境管理センター | |
| 出版物タイトル | 環境制御 |
| 発行日 | 2016-11 |
| 巻 | 38巻 |
| ISSN | 0917-1533 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| フルテキストURL | erc_038_colophon.pdf |
|---|---|
| 著者 | 岡山大学環境管理センター | |
| 出版物タイトル | 環境制御 |
| 発行日 | 2016-11 |
| 巻 | 38巻 |
| ISSN | 0917-1533 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| フルテキストURL | erc_038_040.pdf |
|---|---|
| 著者 | 永禮 英明| |
| 出版物タイトル | 環境制御 |
| 発行日 | 2016-11 |
| 巻 | 38巻 |
| 開始ページ | 40 |
| 終了ページ | 40 |
| ISSN | 0917-1533 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| 著者 | 岡山大学環境管理センター | |
|---|---|
| 出版物タイトル | 環境制御 |
| 発行日 | 2016-11 |
| 巻 | 38巻 |
| 開始ページ | 39 |
| 終了ページ | 39 |
| ISSN | 0917-1533 |
| 言語 | 日本語 |
| 論文のバージョン | none |
| フルテキストURL | erc_038_032_038.pdf |
|---|---|
| 著者 | 岡山大学環境管理センター | |
| 出版物タイトル | 環境制御 |
| 発行日 | 2016-11 |
| 巻 | 38巻 |
| 開始ページ | 32 |
| 終了ページ | 38 |
| ISSN | 0917-1533 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| フルテキストURL | erc_038_028_031.pdf |
|---|---|
| 著者 | 岡山大学環境管理センター | |
| 出版物タイトル | 環境制御 |
| 発行日 | 2016-11 |
| 巻 | 38巻 |
| 開始ページ | 28 |
| 終了ページ | 31 |
| ISSN | 0917-1533 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| 著者 | 岡山大学環境管理センター | |
|---|---|
| 抄録 | 出前講義の実施状況、講習会等開催状況、公開講演会等開催状況、研究活動 |
| 出版物タイトル | 環境制御 |
| 発行日 | 2016-11 |
| 巻 | 38巻 |
| 開始ページ | 12 |
| 終了ページ | 27 |
| ISSN | 0917-1533 |
| 言語 | 日本語 |
| 論文のバージョン | none |
| フルテキストURL | erc_038_001.pdf |
|---|---|
| 著者 | 西村 伸一| |
| 出版物タイトル | 環境制御 |
| 発行日 | 2016-11 |
| 巻 | 38巻 |
| 開始ページ | 1 |
| 終了ページ | 1 |
| ISSN | 0917-1533 |
| オフィシャル URL | http://www.okayama-u.ac.jp/user/emc| |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| フルテキストURL | erc_038_002_011.pdf |
|---|---|
| 著者 | 永禮 英明| |
| 出版物タイトル | 環境制御 |
| 発行日 | 2016-11 |
| 巻 | 38巻 |
| 開始ページ | 2 |
| 終了ページ | 11 |
| ISSN | 0917-1533 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |