検索結果 - 岡山大学学術成果リポジトリ

Factors Predicting a Favorable Disease Course Without Anti-TNF Therapy in Crohn’s Disease Patients

JaLCDOI	10.18926/AMO/60363
フルテキストURL	74_4_265.pdf
著者	Inokuchi, Toshihiro\| Hiraoka, Sakiko\| Yasutomi, Eriko\| Oka, Shohei\| Yamasaki, Yasushi\| Kinugasa, Hideaki\| Takahar, Masahiro\| Kawano, Seiji\| Harada, Keita\| Okada, Hiroyuki\| Kato, Jun\|
抄録	Determining factors that predict a favorable disease course without anti-tumor necrosis factor (TNF) agents would help establish a more cost-effective strategy for Crohn’s disease (CD). A retrospective chart review was performed for CD patients with disease durations > 10 years who had not received anti-TNF agents as first-line therapy. Patients were divided into 2 groups: those who received neither anti-TNF agents nor bowel resection (G1), and those who had received an anti-TNF agent and/or bowel resection (G2). The patient backgrounds, therapies and clinical courses were compared between the groups. A total of 62 CD patients met the inclusion criteria (males: 71%; median duration of follow-up: 19 years). Six patients were included in G1; they were significantly less likely to have upper gastrointestinal lesions than G2 (p=0.007). A multivariate analysis revealed that the significant factors for avoidance of bowel resection without anti-TNF treatment were non-stricturing and non-penetrating behaviors, and absence of upper gastrointestinal lesions at the diagnosis (hazard ratios 0.41 and 0.52; p=0.004 and 0.04, respectively). In consideration of the long treatment course of CD, patients with non-stricturing and non-penetrating behaviors and no upper gastrointestinal lesions should not be treated with anti-TNF agents as first-line therapy.
キーワード	Crohn’s disease anti-TNF agent upper gastrointestinal lesion bamboo joint-like appearance
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-08
巻	74巻
号	4号
出版者	Okayama University Medical School
開始ページ	265
終了ページ	274
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32843757
Web of Science KeyUT	000562508700001
NAID	120006880202

The role of RND-type efflux pumps in multidrug-resistant mutants of Klebsiella pneumoniae

フルテキストURL	fulltext.pdf
著者	Ni, Rui Ting\| Onishi, Motoyasu\| Mizusawa, Minako\| Kitagawa, Ryoko\| Kishino, Takanori\| Matsubara, Futoshi\| Tsuchiya, Tomofusa\| Kuroda, Teruo\| Ogawa, Wakano\|
キーワード	Antimicrobial resistance Bacteria Bacteriology
発行日	2020-07-02
出版物タイトル	Scientific Reports
巻	10巻
号	1号
出版者	Nature
開始ページ	10876
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2020
論文のバージョン	publisher
PubMed ID	32616840
DOI	10.1038/s41598-020-67820-x
Web of Science KeyUT	000550001000001
関連URL	isVersionOf https://doi.org/10.1038/s41598-020-67820-x

Pressure dependence of Si diffusion in γ-Fe

タイトル（別表記）	Pressure dependence of Si diffusion in gamma-Fe
フルテキストURL	fulltext.pdf
著者	Tsujino, Noriyoshi\| Mârza, Andreea\| Yamazaki, Daisuke\|
キーワード	γ-Fe silicon diffusion high pressure planetary core
備考	This is an Accepted Manuscript of an article published by Mineralogical Society of America.\|
発行日	2020-05-01
出版物タイトル	American Mineralogist
巻	105巻
号	3号
出版者	Mineralogical Society of America
開始ページ	319
終了ページ	324
ISSN	0003-004X
NCID	AA00521712
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
DOI	10.2138/am-2020-7197
Web of Science KeyUT	000518370300003
関連URL	isVersionOf https://doi.org/10.2138/am-2020-7197

Effect of Vonoprazan on Delayed Bleeding after Endoscopic Submucosal Dissection for Gastric Neoplasia among Antithrombotic Drug Users: A Single-Center, Single-Arm Prospective Observational Case Control Study

JaLCDOI	10.18926/AMO/59958
フルテキストURL	74_3_245.pdf
著者	Yamamoto, Shumpei\| Takayama, Hiroshi\| Shimodate, Yuichi\| Takezawa, Rio\| Nishimura, Naoyuki\| Doi, Akira\| Mouri, Hirokazu\| Matsueda, Kazuhiro\| Mizuno, Motowo\| Okada, Hiroyuki\|
抄録	Antithrombotic therapy is a major risk factor for delayed bleeding after endoscopic submucosal dissection (ESD) for gastric neoplasia. A potassium-competitive acid blocker, vonoprazan, is expected to prevent delayed bleeding better than conventional proton pomp inhibitors (PPIs), but the evidence is controversial. We sought to clarify the efficacy of vonoprazan for prevention of delayed bleeding after gastric ESD in patients under antithrombotic therapy. We prospectively registered 50 patients who underwent gastric ESD while receiving antithrombotic therapy and vonoprazan in our institution between October 2017 and September 2018. The incidence of delayed bleeding was compared with that in a historical control group of 116 patients treated with conventional PPI. We also evaluated risk factors associated with delayed bleeding. Delayed bleeding was observed in 8 of 50 patients (16.0%), which was not dissimilar from the incidence in the historical control group (12.1%) (p=0.49). In the univariate analysis, age (> 70 years) (p=0.034), multiple antithrombotic drug use (p<0.01), procedure time (> 200 min) (p=0.038) and tumor size (> 40 mm) (p<0.01) were associated with delayed bleeding after gastric ESD, but vonoprazan was not (p=0.49). Vonoprazan may not be more effective than conventional PPIs in preventing delayed bleeding after gastric ESD in patients receiving antithrombotic therapy.
キーワード	vonoprazan endoscopic submucosal dissection antithrombotic drug gastric cancer
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-06
巻	74巻
号	3号
出版者	Okayama University Medical School
開始ページ	245
終了ページ	250
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32577023
Web of Science KeyUT	000543363400008
NAID	120006862799

Serum REIC/Dickkopf-3 Protein Level Predicts Disease-Free Survival in Patients with Hepatocellular Carcinoma

JaLCDOI	10.18926/AMO/59957
フルテキストURL	74_3_237.pdf
著者	Oyama, Atsushi\| Uchida, Daisuke\| Shiraha, Hidenori\| Sawahara, Hiroaki\| Kato, Ryo\| Iwamuro, Masaya\| Horiguchi, Shigeru\| Okada, Hiroyuki\|
抄録	The physiological role of the reduced expression of immortalized cells (REIC)/Dickkopf-3 (Dkk-3) protein in patients with hepatocellular carcinoma (HCC) remains unclear. In this study, we evaluated the effect of the REIC/Dkk-3 protein on HCC cell proliferation and assessed the relationship between the serum REIC/Dkk-3 protein level and the prognosis in patients with HCC. We evaluated the REIC/Dkk-3 protein-induced anticancer effects on Huh7 and Hep3B cells (HCC cell lines) in the presence of peripheral blood mononuclear cells (PBMCs), and found that combination treatment with REIC/Dkk-3 protein and PBMCs reduced the proliferation of HCC cells (Hep3B: 82.0%±16.3%; Huh7: 72.6%±9.1%). We also studied 194 HCC patients who underwent primary liver resection or primary radiofrequency ablation from 2008 to 2017. Serum REIC/Dkk-3 protein levels were measured by an enzyme-linked immunosorbent assay and compared to the prognostic data. The 3-year disease-free survival of the REIC/Dkk-3 high group was significantly higher than that in the REIC/Dkk-3 low group. In conclusion, this is the first study investigating the relationship between HCC patient survival and serum REIC/Dkk-3 protein levels in a large population. Based on the results, the serum REIC/Dkk-3 protein level should be considered a new prognostic marker for patients with HCC.
キーワード	enzyme-linked immunosorbent assay liver resection primary radiofrequency ablation Huh7 Hep3B
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-06
巻	74巻
号	3号
出版者	Okayama University Medical School
開始ページ	237
終了ページ	243
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32577022
Web of Science KeyUT	000543363400007
NAID	120006862798

Formulas to Estimate Appropriate Surgical Amounts of Unilateral Recession-Resection in Intermittent Exotropia with Distance-Near Disparity

JaLCDOI	10.18926/AMO/59956
フルテキストURL	74_3_229.pdf
著者	Shibata, Kiyo\| Hamasaki, Ichiro\| Toshima, Shinji\| Shimizu, Takehiro\| Kono, Reika\| Miyata, Manabu\| Morisawa, Shin\| Furuse, Takashi\| Hasebe, Satoshi\| Ohtsuki, Hiroshi\| Morizane, Yuki\| Shiraga, Fumio\|
抄録	The purpose of this study was to derive new formulas to provide an optimal surgical procedure and optimal amount of recession-resection (RR) surgery in intermittent exotropia (IXT) with a disparity in angle of deviation depending on the fixation distance. The records of 117 consecutive patients with IXT who underwent RR surgery between March 2008 and December 2011 at Okayama University Hospital were retrospectively examined. Multivariable linear regression analysis was performed using the observed corrective angle of deviation at distance or near fixation as the dependent variable, and amounts of lateral rectus muscle (LR) recession (mm) and medial rectus muscle (MR) resection, and age at surgery (years) as independent variables. Two simultaneous formulas were derived: corrective angle of deviation at distance fixation (°)=1.8×recession (mm)+1.6× resection (mm)+0.15×age (years)–6.6, and corrective angle at near fixation (°)=1.5×recession (mm)+1.7× resection (mm)+0.18×age (years)–3.8. Comparisons of coefficient values of the formulas between distance and near fixation revealed that LR recession was more affected by the corrective angle in distance than near fixation. MR resection was more affected at near than distance fixation. We found that our new formulas estimated the appropriate amount of unilateral RR surgery.
キーワード	surgical amount intermittent exotropia recession and resection procedure strabismus surgery recurrent exotropia
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-06
巻	74巻
号	3号
出版者	Okayama University Medical School
開始ページ	229
終了ページ	236
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32577021

A Possible Protective Effect of the 'Cam Deformity' on Femoral Neck Fracture: The Relationship between Hip Morphology and the Types of Hip Fracture

JaLCDOI	10.18926/AMO/59954
フルテキストURL	74_3_221.pdf
著者	Yagura, Takuma\| Oe, Kenichi\| Paku, Masaaki\| Tajima, Takeshi\| Nakamura, Masaya\| Iida, Hirokazu\| Saito, Takanori\|
抄録	We retrospectively evaluated the cases of 169 hip fracture patients, their previous fractures, and the contralateral hip joint’s morphology. A history of contralateral hip fracture was present in 23 patients (Contra group). The other patients had a unilateral hip fracture: a trochanteric fracture (Troch group, n=73) or a femoral neck fracture (Neck group, n=73). In the Troch and Neck groups, we used anteroposterior and cross-table axialview radiographs of the contralateral hip to evaluate the proximal femur’s anatomy. In the Contra group, the concordance rate between the first and second types of hip fracture was 65.2%, and the second hip fracture’s morphology indicated that the trochanteric fracture had a cam deformity in terms of the femoral head-neck ratio. The average alpha angle and femoral head-neck offset in the Troch group were significantly larger than those in the Neck group. In the Neck group, pistol-grip deformities of Arbeitsgemeinschaft für Osteosynthesefragen types B1 (subcapital), B2 (transcervical), and B3 (displaced) were observed in 42.1%, 75%, and 6% of cases, respectively. There was a smaller alpha angle and a larger femoral head-neck offset in the contralateral hip of femoral neck fractures; thus, the “cam deformity” may protect against femoral neck fractures.
キーワード	cam deformity femoral neck fracture trochanteric fracture bilateral hip fractures
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-06
巻	74巻
号	3号
出版者	Okayama University Medical School
開始ページ	221
終了ページ	227
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32577020
Web of Science KeyUT	000543363400006
NAID	120006862796

Concentration of meteoritic free organic matter by fluid transport and adsorption

フルテキストURL	fulltext.pdf
著者	Potiszil, C.\| Tanaka, R.\| Ota, T.\| Kunihiro, T.\| Kobayashi, K.\| Nakamura, E.\|
キーワード	carbonaceous chondrites free organic matter adsorption geochromatographic separation DESI-OT-MS Raman spectroscopy
発行日	2020-03-17
出版物タイトル	Geochemical Perspectives Letters
巻	13巻
出版者	European Association of Geochemistry
開始ページ	30
終了ページ	35
ISSN	2410-339X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	Copyright © The Authors
論文のバージョン	publisher
DOI	10.7185/geochemlet.2010
Web of Science KeyUT	000523230000001
関連URL	isVersionOf https://doi.org/10.7185/geochemlet.2010

Extracellular Vesicles Enriched with Moonlighting Metalloproteinase Are Highly Transmissive, Pro-Tumorigenic, and Trans-Activates Cellular Communication Network Factor (CCN2/CTGF): CRISPR against Cancer

フルテキストURL	fulltext.pdf
著者	Okusha, Yuka\| Eguchi, Takanori\| Tran, Manh T.\| Sogawa, Chiharu\| Yoshida, Kaya\| Itagaki, Mami\| Taha, Eman A.\| Ono, Kisho\| Aoyama, Eriko\| Okamura, Hirohiko\| Kozaki, Ken-Ichi\| Calderwood, Stuart K.\| Takigawa, Masaharu\| Okamoto, Kuniaki\|
キーワード	matrix metalloproteinase moonlighting metalloproteinase (MMP) protein moonlighting transcription factor extracellular vesicles oncosome genome editing CRISPR cellular communication network factor CCN2/CTGF
発行日	2020-04-04
出版物タイトル	Cancers
巻	12巻
号	4号
出版者	MDPI
開始ページ	881
ISSN	2072-6694
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 by the authors.
論文のバージョン	publisher
PubMed ID	32260433
DOI	10.3390/cancers12040881
Web of Science KeyUT	000535587400110
関連URL	isVersionOf https://doi.org/10.3390/cancers12040881

Reference values for the locomotive syndrome risk test quantifying mobility of 8681 adults aged 20–89 years: A cross-sectional nationwide study in Japan

フルテキストURL	fulltext.pdf
著者	Yamada, Keiko\| Ito, Yoichi M.\| Akagi, Masao\| Chosa, Etsuo\| Fuji, Takeshi\| Hirano, Kenichi\| Ikeda, Shinichi\| Ishibashi, Hideaki\| Ishibashi, Yasuyuki\| Ishijima, Muneaki\| Itoi, Eiji\| Iwasaki, Norimasa\| Izumida, Ryoichi\| Kadoya, Ken\| Kamimura, Masayuki\| Kanaji, Arihiko\| Kato, Hiroyuki\| Kishida, Shunji\| Mashima, Naohiko\| Matsuda, Shuichi\| Matsui, Yasumoto\| Matsunaga, Toshiki\| Miyakoshi, Naohisa\| Mizuta, Hiroshi\| Nakamura, Yutaka\| Nakata, Ken\| Omori, Go\| Osuka, Koji\| Uchio, Yuji\| Ryu, Kazuteru\| Sasaki, Nobuyuki\| Sato, Kimihito\| Senda, Masuo\| Sudo, Akihiro\| Takahira, Naonobu\| Tsumura, Hiroshi\| Yamaguchi, Satoshi\| Yamamoto, Noriaki\| Nakamura, Kozo\| Takashi, Ohe\|
発行日	2020-03-12
出版物タイトル	Journal of Orthopaedic Science
出版者	Elsevier
ISSN	09492658
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 The Authors.
論文のバージョン	publisher
PubMed ID	32173180
DOI	10.1016/j.jos.2020.01.011

Simultaneous degradation and dechlorination of poly (vinyl chloride) by a combination of superheated steam and CaO catalyst/adsorbent

フルテキストURL	PDS_179.pdf
著者	Nishibata, Haruka\| Uddin, Md. Azhar\| Kato, Yoshiei\|
キーワード	Dechloriation Waste plastics PVC Superheated steam CaO Adsorbent Catalyst
備考	© 2020 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.polymdegradstab.2020.109225] . \|
発行日	2020-05-26
出版物タイトル	Polymer Degradation and Stability
巻	179巻
出版者	Elsevier
開始ページ	109225
ISSN	0141-3910
NCID	AA00362801
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 Elsevier Ltd.
論文のバージョン	author
DOI	10.1016/j.polymdegradstab.2020.109225
Web of Science KeyUT	000564495800014
関連URL	isVersionOf https://doi.org/10.1016/j.polymdegradstab.2020.109225

Lennard-Jones Parameters Determined to Reproduce the Solubility of NaCl and KCl in SPC/E, TIP3P, and TIP4P/2005 Water

フルテキストURL	fulltext.pdf
著者	Yagasaki, Takuma\| Matsumoto, Masakazu\| Tanaka, Hideki\|
備考	This is an Accepted Manuscript of an article published by American Chemical Society \|
発行日	2020-04-24
出版物タイトル	Journal of Chemical Theory and Computation
巻	16巻
号	14号
出版者	American Chemical Society
開始ページ	2460
終了ページ	2473
ISSN	15499618
NCID	AA12005233
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	32207974
DOI	10.1021/acs.jctc.9b00941
Web of Science KeyUT	000526313000038
関連URL	isVersionOf https://doi.org/10.1021/acs.jctc.9b00941

Genomic characterization of antibiotic resistance‐encoding genes in clinical isolates of Vibrio cholerae non‐O1/non‐O139 strains from Kolkata, India: generation of novel types of genomic islands containing plural antibiotic resistance genes

フルテキストURL	fulltext.pdf
著者	Morita, Daichi\| Takahashi, Eizo\| Morita, Masatomo\| Ohnishi, Makoto\| Mizuno, Tamaki\| Miyoshi, Shin‐ichi\| Dutta, Devarati\| Ramamurthy, Thandavarayan\| Chowdhury, Goutam\| Mukhopadhyay, Asish K.\| Okamoto, Keinosuke\|
キーワード	antibiotic resistance diarrhea genome sequence genomic island integron Vibrio cholerae
備考	This is the peer reviewed version of the following article: Daichi Morita et. al. Genomic characterization of antibiotic resistance‐encoding genes in clinical isolates of Vibrio cholerae non‐O1/non‐O139 strains from Kolkata, India: generation of novel types of genomic islands containing plural antibiotic resistance genes. Microbiology and Immunology 64(6) 435-444 (2020), which has been published in final form at https://doi.org/10.1111/1348-0421.12790. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.\|
発行日	2020-03-28
出版物タイトル	Microbiology and Immunology
巻	64巻
号	6号
出版者	Wiley
開始ページ	435
終了ページ	444
ISSN	03855600
NCID	AA00738350
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	32222116
DOI	10.1111/1348-0421.12790
Web of Science KeyUT	000527073000001
関連URL	isVersonOf https://doi.org/10.1111/1348-0421.12790

Analysis of Factors Associated With Radiation-Induced Bronchiolitis Obliterans Organizing Pneumonia Syndrome After Breast-Conserving Therapy

フルテキストURL	fulltext.pdf
著者	Katayama, Norihisa\| Sato, Shuhei\| Katsui, Kuniaki\| Takemoto, Mitsuhiro\| Tsuda, Toshihide\| Yoshida, Atsushi\| Morito, Tsuneharu\| Nakagawa, Tomio\| Mizutani, Akifumi\| Waki, Takahiro\| Niiya, Harutaka\| Kanazawa, Susumu\|
キーワード	Breast cancer Breast-conserving surgery Radiotherapy Radiation-induced BOOP syndrome Endocrine therapy
発行日	2009-03-15
出版物タイトル	International journal of radiation oncology, biology, physics
巻	73巻
号	4号
出版者	Elsevier
開始ページ	1049
終了ページ	1054
ISSN	0360-3016
NCID	AA00680920
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	author
PubMed ID	18755559
DOI	10.1016/j.ijrobp.2008.05.050
Web of Science KeyUT	000264257400014
関連URL	isVersionOf https://doi.org/10.1016/j.ijrobp.2008.05.050

The Efficacy of Mirabegron for the Relief of Ureteral Stent-Related Symptoms

JaLCDOI	10.18926/AMO/58273
フルテキストURL	74_2_145.pdf
著者	Otsuki, Hideo\| Yamasaki, Tomoya\| Hori, Shunsuke\| Aoki, Hiroshi\| Kosaka, Takeo\| Uehara, Shinya\| Fujio, Kei\|
抄録	To investigate the efficacy of mirabegron for lower urinary tract symptoms in patients with an indwelling ureteral stent after ureterorenoscopic lithotripsy. This was a prospective follow-up study of 76 patients with stent-related symptoms (SRSs). Patients with upper urinary calculi who were pre-stented for > 2 weeks before lithotripsy were examined for the presence of SRSs by tests including the International Prostate Symptom Score (IPSS), OAB Symptom Score (OABSS), and urinary bother and pain measured by a Visual Analogue Scale (VAS) before lithotripsy. Mirabegron (50 mg/day) was prescribed post-lithotripsy for 2 weeks. SRSs were assessed at the time of stent removal. The IPSS scores improved significantly from 16.2 to 14.3 (p<0.001) and the IPSS-QoL scores decreased significantly from 5.0 to 4.6 (p=0.012). The OABSS scores improved significantly from 7.7 to 6.8 (p=0.006), and the urinary urgency scores (OABSS-Q3) decreased significantly from 3.24 to 2.68 (p<0.001). The number of nocturia episodes decreased significantly from 2.5 to 2.2 (p=0.045). Urinary bother and pain assessed by the VAS declined from 4.2 and 3.1 to 3.8 (p=0.15) and 2.5 (p=0.075), respectively. Mirabegron significantly improved SRSs and the number of nocturia episodes due to a ureteral stent.
キーワード	stent-related symptoms overactive bladder mirabegron ureterorenoscopic lithotripsy ureteral stent
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-04
巻	74巻
号	2号
出版者	Okayama University Medical School
開始ページ	145
終了ページ	150
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32341589
Web of Science KeyUT	000528278500008
NAID	120006839452

Mucinous Carcinoma of the Breast: Clinicopathological Features and Long-term Prognosis in Comparison with Invasive Ductal Cancer; A Single Hospital’s 30+-Year Experience

JaLCDOI	10.18926/AMO/58272
フルテキストURL	74_2_137.pdf
著者	Isozaki, Hiroshi\| Yamamoto, Yasuhisa\| Sakai, Kunihiko\| Sho, Tatuo\| Ishihara, Kiyohiro\| Murakami, Shigeki\| Matsumoto, Sasau\| Takama, Takehiro\|
抄録	Mucinous carcinoma (MC) of the breast is a rare and special type of malignancy, with a substantial amount of extracellular mucin. We compared the clinicopathological features and the long-term survival of MC patients with those of invasive ductal carcinoma-no special type (IDC-NST) patients, and we examined prognostic factors of MC. A total of 116 patients with mucinous carcinoma and 3,258 patients with IDC-NST who underwent surgery at our hospital (1977-2008) were enrolled. The 10-year overall survival rate and breast cancer-specific survival rate (BSS) of the MC patients (88.3%, 93.7%) were both significantly higher than those of IDC-NST patients (81.6%, 85.0%) (p=0.015, p=0.005, respectively). A Cox regression analysis demonstrated that MC tended to be an independent prognostic factor (hazard ratio 0.44, p=0.098). The BSS of the MC patients with positive lymph node (LN) metastasis was significantly poorer than that of the patients without it, by univariate analysis (p=0.002). The tumor size in the MC patients with positive LN metastasis (mean 3.2 cm) was significantly larger than that in the patients without it (mean 1.9 cm) (p=0.0004). Although a Cox regression analysis revealed no independent factor, MC patients with positive LN metastasis should be treated for advanced invasive ductal breast cancer.
キーワード	breast cancer mucinous carcinoma clinicopathological features long-term prognosis
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-04
巻	74巻
号	2号
出版者	Okayama University Medical School
開始ページ	137
終了ページ	143
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32341588
Web of Science KeyUT	000528278500007
NAID	120006839451

Association between Histological Types and Enhancement of Dynamic CT for Primary Lung Cancer

JaLCDOI	10.18926/AMO/58271
フルテキストURL	74_2_129.pdf
著者	Fukuma, Shogo\| Shinya, Takayoshi\| Soh, Junichi\| Fukuhara, Ryuichiro\| Ogawa, Nanako\| Higaki, Fumiyo\| Tanaka, Takehiro\| Ichihara, Eiki\| Hiraki, Takao\| Toyooka, Shinichi\| Kanazawa, Susumu\|
抄録	The aim of this study was to explore enhancement patterns of different types of primary lung cancers on 2-phase dynamic computed tomography (CT). This study included 217 primary lung cancer patients (141 adenocarcinomas [ADs], 48 squamous cell carcinomas [SCCs], 20 small cell lung carcinomas [SCLCs], and 8 others) who were examined using a 2-phase dynamic scan. Regions of interest were identified and mean enhancement values were calculated. After excluding the 20 SCLCs because these lesions had different clinical stages from the other cancer types, the mean attenuation values and subtractions between phases were compared between types of non-small cell lung carcinomas (NSCLCs) using the Kruskal–Wallis test. Late phase attenuation and attenuation of the late minus unenhanced phase (LMU) of SCCs were significantly higher than those of ADs (p<0.05). To differentiate SCC and AD in the late phase, a threshold of 80.21 Hounsfield units (HU) gave 52.9% accuracy. In LMU, a threshold of 52.16 HU gave 59.3% accuracy. Dynamic lung CT has the potential to aid in differentiating among NSCLC types.
キーワード	differentiation dynamic computed tomography primary lung cancer enhancement pattern
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-04
巻	74巻
号	2号
出版者	Okayama University Medical School
開始ページ	129
終了ページ	135
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32341587
Web of Science KeyUT	000528278500006
NAID	120006839450

The Diagnostic Capacity of Pre-treatment 18F-FDG PET/CT for Predicting the Extranodular Spread of Lymph Node Metastases in Patients with Oral Squamous Cell Carcinoma

JaLCDOI	10.18926/AMO/58270
フルテキストURL	74_2_123.pdf
著者	Fukuhara, Ryuichiro\| Shinya, Takayoshi\| Fukuma, Shogo\| Ogawa, Nanako\| Masaoka, Yoshihisa\| Tanaka, Takehiro\| Marunaka, Hidenori\| Arioka, Tadashi\| Hiraki, Takao\| Kaji, Mitsumasa\| Kanazawa, Susumu\|
抄録	The aim of this study was to evaluate the ability of pretreatment 90-min 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) to predict the extranodular spread of lymph node metastases in oral squamous cell carcinoma. We retrospectively reviewed the cases of 56 patients who underwent pretreatment 18F-FDG PET/CT and surgery with neck dissection. Maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis were measured for the 56 primary sites and maximum standardized uptake value was measured for 115 lymph node levels. Extranodular spread was present at 9 lymph node levels in 7 patients. Significant differences were found in metabolic tumor volume and total lesion glycolysis of the primary site, and in lymph node maximum standardized uptake value, between patients with and without extranodular spread (p<0.05). Combining primary site total lesion glycolysis and lymph node maximum standardized uptake volume at their respective optimal cutoffs, the sensitivity, specificity, and accuracy for predicting extranodular spread were 89%, 92%, and 92%, respectively. Pretreatment 18F-FDG PET/CT is useful for predicting extranodular spread in patients with oral squamous cell carcinoma. The combined use of primary site total lesion glycolysis and lymph node maximum standardized uptake value showed greater predictive value than either predictor singly.
キーワード	18F-fluorodeoxyglucose positron emission tomography/computed tomography extranodular spread metastasis oral squamous cell carcinoma
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-04
巻	74巻
号	2号
出版者	Okayama University Medical School
開始ページ	123
終了ページ	128
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32341586
Web of Science KeyUT	000528278500005
NAID	120006839449

Increased Plasma Levels of Platelet Factor 4 and β-thromboglobulin in Women with Recurrent Pregnancy Loss

JaLCDOI	10.18926/AMO/58269
フルテキストURL	74_2_115.pdf
著者	Kotani, Sayoko\| Kamada, Yasuhiko\| Shimizu, Keiko\| Sakamoto, Ai\| Nakatsuka, Mikiya\| Hiramatsu, Yuji\| Masuyama, Hisashi\|
抄録	Thrombosis in decidual vessels is one of the mechanisms of pregnancy loss. However, few studies have assessed the relation between platelet activation, which is known to cause of thrombosis, and recurrent pregnancy loss (RPL). We investigated platelet activation in women with RPL compared to controls by measuring plasma levels of platelet factor 4 (PF4) and β-thromboglobulin (βTG), and assessed correlations between PF4/βTG and coagulative risk factors associated with RPL. The study group included 135 women who had experienced two or more consecutive pregnancy losses. The control group included 28 age-matched healthy women who had never experienced pregnancy loss. PF4 and βTG plasma levels were significantly higher in the women with RPL than controls (PF4: 14.0 [8.0-20.0] vs. 9.0 [6.0-12.0] ng/ml, p=0.043; βTG: 42.0 [24.3-59.8] vs. 31.5 [26.6-36.4] ng/ml, p=0.002). There was a significant association between βTG and anti-phosphatidylethanolamine antibody immunoglobulin M (aPE IgM) (p=0.048). Among the women with RPL, 18 of those who were positive for PF4 (45%) and 18 of those who were positive for βTG (37%) were negative for all known coagulative risk factors associated with RPL. Measurements of PF4 and βTG may be important because they help identify women who are at risk of RPL.
キーワード	recurrent pregnancy loss platelet factor 4 β-thromboglobulin platelet activation
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-04
巻	74巻
号	2号
出版者	Okayama University Medical School
開始ページ	115
終了ページ	122
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32341585
Web of Science KeyUT	000528278500004
NAID	120006839448

The Efficacy of Software to Help Patients Understand Drug for Adjuvant Treatment for Breast Cancer: A Pilot Randomized Controlled Trial

JaLCDOI	10.18926/AMO/58266
フルテキストURL	74_2_95.pdf
著者	Kuba, Sayaka\| Yamanouchi, Kosho\| Morita, Michi\| Sakimura, Chika\| Inamasu, Eiko\| Hatachi, Toshiko\| Otsubo, Ryota\| Matsumoto, Megumi\| Yano, Hiroshi\| Miyamoto, Junya\| Sato, Shuntaro\| Nakagawa, Hiroo\| Kanetaka, Kengo\| Takatsuki, Mitsuhisa\| Nagayasu, Takeshi\| Eguchi, Susumu\|
抄録	We assessed the usefulness of ChemoCalc, a software package for calculating drug costs, in helping patients understand these costs. We randomly assigned, in a 1 : 1 ratio, 20 women who had undergone surgery for early breast cancer to a group that discussed adjuvant treatment with their physicians using the ChemoCalc software (ChemoCalc group) or a group that discussed adjuvant treatment without ChemoCalc (Usual Explanation group). The participants completed a five-grade evaluation questionnaire after these discussions. The primary endpoint was the intergroup comparison of the questionnaire scores regarding participants’ understanding of their treatment-associated drug costs. Median age was not significantly different between the ChemoCalc group and Usual Explanation group (57 vs. 50, respectively; p=0.27). Patients in the ChemoCalc group had a significantly higher perceived level of understanding of the drug cost than those in the Usual Explanation group (5 [4-5] vs. 2.5 [1-5], respectively; p=0.002). Scores related to the patients’ perception that understanding drug costs is an important part of breast cancer treatment were also higher in the ChemoCalc group than the Usual Explanation group (5 [2-5] vs. 3 [1-5], respectively; p=0.049). ChemoCalc was found to be useful for understanding drug costs.
キーワード	breast cancer drug costs ChemoCalc
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-04
巻	74巻
号	2号
出版者	Okayama University Medical School
開始ページ	95
終了ページ	101
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	32341582
Web of Science KeyUT	000528278500001
NAID	120006839445