検索条件

閉じる

検索結果 15921 件

フルテキストURL Blood advances 2018.pdf
著者 Inamoto, Yoshihiro| Matsuda, Tomohiro| Tabuchi, Ken| Kurosawa, Saiko| Nakasone, Hideki| Nishimori, Hisakazu| Yamasaki, Satoshi| Doki, Noriko| Iwato, Koji| Mori, Takehiko| Takahashi, Satoshi| Yabe, Hiromasa| Kohno, Akio| Nakamae, Hirohisa| Sakura, Toru| Hashimoto, Hisako| Sugita, Junichi| Ago, Hiroatsu| Fukuda, Takahiro| Ichinohe, Tatsuo| Atsuta, Yoshiko| Yamashita, Takuya| Japan Society for Hematopoietic Cell Transplantation Late Effects and Quality of Life Working Group|
発行日 2018-08
出版物タイトル Blood Advances
巻 2巻
号 15号
出版者 American Society of Hematology
開始ページ 1901
終了ページ 1903
ISSN 2473-9529
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン publisher
PubMed ID 30087108
DOI 10.1182/bloodadvances.2018020966
関連URL isVersionOf https://doi.org/10.1182/bloodadvances.2018020966
フルテキストURL K0006020_abstract_review.pdf K0006020_summary.pdf K0006020_fulltext.pdf
著者 小田 尚廣|
発行日 2019-06-30
資料タイプ 学位論文
学位授与番号 甲第6020号
学位授与年月日 2019-06-30
学位・専攻分野 博士(医学)
授与大学 岡山大学
言語 英語
フルテキストURL K0006013_abstract_review.pdf K0006013_summary.pdf K0006013_fulltext.pdf
著者 濵西 誠司|
発行日 2019-06-30
資料タイプ 学位論文
学位授与番号 甲第6013号
学位授与年月日 2019-06-30
学位・専攻分野 博士(医学)
授与大学 岡山大学
言語 英語
フルテキストURL K0006011_abstract_review.pdf K0006011_summary.pdf K0006011_fulltext.pdf
著者 熊田 雄太|
発行日 2019-06-30
資料タイプ 学位論文
学位授与番号 甲第6011号
学位授与年月日 2019-06-30
学位・専攻分野 博士(医学)
授与大学 岡山大学
言語 英語
フルテキストURL K0006009_abstract_review.pdf K0006009_summary.pdf K0006009_fulltext.pdf
著者 吉田 純子|
発行日 2019-06-30
資料タイプ 学位論文
学位授与番号 甲第6009号
学位授与年月日 2019-06-30
学位・専攻分野 博士(医学)
授与大学 岡山大学
言語 英語
タイトル(別表記) Die Rechtstheorie von der landwirtschaftlicher Genossenschaft in Japan
フルテキストURL olj_69_1_(112_83).pdf
著者 田代 滉貴|
出版物タイトル 岡山大學法學會雜誌
発行日 2019-08-30
巻 69巻
号 1号
開始ページ 112
終了ページ 83
ISSN 0386-3050
言語 日本語
論文のバージョン publisher
NAID 120006716049
タイトル(別表記) Development of teaching materials on water color using a plastic pipe as a long path cell : their applications to elementary science lessons
フルテキストURL hyky_19_191.pdf
著者 宮﨑 唯| 安心院 翼| 喜多 雅一|
抄録  Water is an essential substance for living things. Topic on water are at grades 3-6 in elementary science. The roles and functions of water (erosion, accumulation, transportation), germination and growth of plants, etc. On the other hand, the properties of water are not treated except physical change like boiling, evaporation, freezing, etc.
 The color, taste, and smell of water are not discussed in elementary science. This research proposes that the color of water because an excellent theme for inquire based leaning. We have developed a suitable and low cost teaching material for the water color. Furthermore, we have conducted a few lessons with the teaching materials to examine the appropriateness.
キーワード Transmission excited vibrational state of molecule Long light path cell Absorption of light
出版物タイトル 教育実践学論集
発行日 2018-03
号 19号
開始ページ 191
終了ページ 196
ISSN 2433-1791
関連URL isVersionOf http://hdl.handle.net/10132/17608
言語 日本語
論文のバージョン publisher
NAID 120006455118
JaLCDOI 10.18926/AMO/56940
フルテキストURL 73_4_367.pdf
著者 Mifune-Morioka, Tomoyo| A. Uchida, Haruhito| Fukushima, Kazuhiko| Watanabe, Mayu| Ouchi, Chihiro| Mise, Koki| Kawakita, Chieko| Kano, Yuzuki| Onishi, Akifumi| Toma, Kishio| Eguchi, Jun| Wada, Nozomu| Ikeda, Fusao| Sasaki, Erika| Suganami, Yu| Kishida, Masayuki| Sugiyama, Hitoshi| Okada, Hiroyuki| Wada, Jun|
抄録 Eight years prior to her present admission, a 61-year-old Japanese woman was diagnosed with autoimmune hepatitis, slowly progressive insulin-dependent diabetes mellitus, and chronic thyroiditis; she had been treated with oral prednisolone (PSL). After she suddenly discontinued PSL, she newly developed systemic lupus erythematosus. A combination therapy of oral PSL and intravenous cyclophosphamide resulted in remission. She was finally diagnosed with autoimmune polyglandular syndrome (APS) type 3 (3A ,3B, 3D), complicated with four different autoimmune diseases. Since patients with type 3 APS may present many manifestations over a long period of time, they should be carefully monitored.
キーワード autoimmune polyglandular syndrome type 3 systemic lupus erythematosus autoimmune hepatitis slowly progressive insulin-dependent diabetes mellitus chronic thyroiditis
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2019-08
巻 73巻
号 4号
出版者 Okayama University Medical School
開始ページ 367
終了ページ 372
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31439961
JaLCDOI 10.18926/AMO/56937
フルテキストURL 73_4_349.pdf
著者 Isozaki, Hiroshi| Yamamoto, Yasuhisa| Murakami, Shigeki| Matsumoto, Sasau| Takama, Takehiro|
抄録 To clarify the surgical outcomes of breast cancer patients with a preoperative diagnosis of ductal carcinoma in situ (DCIS) by core needle biopsy (CNB) (abbreviated as CNBDCIS), we retrospectively analyzed the cases of 131 patients with CNBDCIS who underwent surgery at Oomoto Hospital (32 total mastectomies, 99 conservative mastectomies). Our analysis of underestimation and predictors of invasive breast cancer of CNBDCIS revealed that the underestimation rate of CNBDCIS was 40.5% (53/131). A logistic regression analysis revealed that palpable tumors (yes to no, odds ratio [OR] 3.25), mammography (MMG) category group (category 4 or 5 to categories 1 , 2, or 3, OR 4.69) and MMG microcalcifications (no to yes, OR 0.24) were significant predictive factors for CNBDCIS invasion. In our analysis of the predictors of positive margins during CNBDCIS surgery, 36 (27.5%) of the 131 patients had positive margins after postoperative pathological examination. A logistic regression analysis revealed that the operative procedure (conservative surgery to total mastectomy, OR 21.4) and MMG microcalcifications (yes to no, OR 3.35) were significant factors related to positive margins during CNBDCIS surgery. Thus, MMG microcalcifications are a negative predictor of upgrading of CNBDCIS and a positive predictor of positive surgical margins for CNBDCIS.
キーワード ductal carcinoma in situ core needle biopsy underestimation positive margins microcalcifications on mammography
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-08
巻 73巻
号 4号
出版者 Okayama University Medical School
開始ページ 349
終了ページ 356
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31439958
JaLCDOI 10.18926/AMO/56936
フルテキストURL 73_4_341.pdf
著者 Kitajima, Kazuhiro| Yamamoto, Shingo| Nakanishi, Yukako| Yamada, Yusuke| Hashimoto, Takahiko| Suzuki, Toru| Go, Shuken| Kanematsu, Akihiro| Nojima, Michio| Fujiwara, Masayuki| Kaida, Hayato| Tsurusaki, Masakatsu| Kanda, Tomonori| Tamaki, Yukihisa | Yamakado, Koichiro|
抄録 We investigated the effectiveness of 11C-choline-positron emission tomography/computed tomography (PET/CT) for evaluating treatment response in patients with prostate cancer or renal cell carcinoma. We performed 34 11C-choline PET/CT scans before/after a combined total of 17 courses of treatment in 6 patients with prostate cancer and 2 with renal cell carcinoma. The 17 treatments including hormonal therapy, radiotherapy, chemotherapy, radium-223, molecular target therapy, radiofrequency ablation, transcatheter arterial embolization, and cancer immunotherapy yielded 1 (5.9%) complete metabolic response (CMR), 3 (17.6%) partial metabolic responses (PMRs), 2 (11.8%) stable metabolic diseases (SMDs), and 11 (64.7%) progressive metabolic diseases (PMDs). Target lesions were observed in bone (n=14), lymph nodes (n=5), lung (n=2), prostate (n=2), and pleura (n=1), with CMR in 4, PMR in 10, SMD in 8 and PMD in 2 lesions. SUVmax values of the target lesions before and after treatment were 7.87±2.67 and 5.29±3.98, respectively, for a mean reduction of −35.4±43.6%. The response for the 8 prostate cancer-treatment courses was PMD, which correlated well with changes in serum prostatic specific antigen (PSA) (7 of 8 cases showed increased PSA). 11C-choline-PET/CT may be an effective tool for detecting viable residual tumors and evaluating treatment response in prostate cancer and renal cell carcinoma patients.
キーワード treatment response 11C-choline PET/CT prostate cancer renal cell carcinoma
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-08
巻 73巻
号 4号
出版者 Okayama University Medical School
開始ページ 341
終了ページ 347
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31439957
JaLCDOI 10.18926/AMO/56935
フルテキストURL 73_4_333.pdf
著者 Kuwaki, Kenji| Nouso, Kazuhiro| Miyashita, Manabi| Makino, Yasuhiro| Hagihara, Hiroaki| Moriya, Akio| Adachi, Takuya| Wada, Nozomu| Yasunaka, Yuki| Yasunaka, Tetsuya| Takeuchi, Yasuto| Onishi, Hideki| Nakamura, Shinichiro| Ikeda, Fusao| Shiraha, Hidenori| Takaki, Akinobu| Okada, Hiroyuki|
抄録 Steroids are often administered at the time of transcatheter arterial chemoembolization (TACE), a standard treatment of hepatocellular carcinoma (HCC), with the expectation of preventing postembolization syndrome. Here we investigated the precise effects of steroids on TACE. We prospectively enrolled 144 HCC patients from 10 hospitals who underwent TACE. Three hospitals used steroids (steroid group, n=77) and the rest did not routinely use steroids (control group, n=67). The occurrence of adverse events and the algetic degree at 1-5 days post-treatment were compared between the groups. Fever (grades 0-2) after TACE was significantly less in the steroid group (56/21/0) compared to the control group (35/29/3, p=0.005, Cochran-Armitage test for trend). The suppressive effect of steroids against fever was prominent in females (p=0.001). Vomiting (G0/G1/ G2-) was also less frequent in the steroid group (70/5/2) versus the control group (53/10/3), but not significantly (p=0.106). The algetic degree and the grade of hematological adverse events, including hyperglycemia, did not differ between the groups. We conclude that the administration of steroids was useful for the prevention of adverse events after TACE in patients with HCC.
キーワード antipyretic hepatocellular carcinoma therapeutic chemoembolization steroid
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-08
巻 73巻
号 4号
出版者 Okayama University Medical School
開始ページ 333
終了ページ 339
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31439956
JaLCDOI 10.18926/AMO/56933
フルテキストURL 73_4_315.pdf
著者 Ono, Shintaro| Nakayama, Masaaki| Tachibana, Masato| Abu Saleh Muhammad Shahriar| Heling, Wang| Takashiba, Shogo| Ohara, Naoya|
抄録 The periodontal pathogen Porphyromonas gingivalis shows colonial pigmentation on blood agar and produces gingipains (Kgp, RgpA, and RgpB), cysteine proteases involved in an organism’s virulence and pigmentation. We showed previously that deletion of the PGN_0300 gene abolished the pigmentation activity and reduced the proteolytic activity of gingipains. The role of the PGN_0297 gene, which consists of an operon with the PGN_0300 gene, is unclear. Herein we examined the effect of PGN_0297 gene deletion on the pigmentation and proteolytic activities and transcriptional levels of gingipains. A PGN_0297 gene deletion mutant (ΔPGN_0297) did not exhibit the pigmentation. The proteolytic activity of the gingipains was decreased in the culture supernatant and on the cell surface of ΔPGN_0297. The mutant ΔPGN_0297 failed to attenuate Akt phosphorylation at Thr308 and Ser473, but both phosphorylations were attenuated in the wild-type and its complementation strain. The deletion of PGN_0297 gene did not substantially affect the transcriptional levels of the gingipain genes kgp, rgpA, and rgpB. Taken together, these results indicate that PGN_0297 is closely involved in the secretion and maturation of gingipains.
キーワード periodontitis Porphyromonas gingivalis gingipain C-terminal domain secretion system
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-08
巻 73巻
号 4号
出版者 Okayama University Medical School
開始ページ 315
終了ページ 323
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31439954
JaLCDOI 10.18926/AMO/56932
フルテキストURL 73_4_307.pdf
著者 Takahashi, Sho| Akagi, Teiji| Toh, Norihisa| Takaya, Yoichi| Nakagawa, Koji| Nishii, Nobuhiro| Ito, Hiroshi|
抄録 The follow-up of patients with adult congenital heart disease (ACHD) at a specialized medical unit is necessary for the patients’ appropriate medical care. However, limited information is available about cardiovascular events among ACHD patients. Here we investigated the type and frequency of cardiovascular events in ACHD patients in relation to disease complexity. We retrospectively analyzed the cases of 535 patients (median age 35 years) referred to our ACHD center between 2014 and 2017. We divided the patients into 3 groups based on their disease complexity. To evaluate the relationship between disease complexity and cardiovascular events, we performed univariate and multivariate survival analyses. The Simple, moderate, and complex disease groups accounted for 62%, 19%, and 19% of the patients, respectively. Apart from events related to atrial septal defect (ASD) trans-catheter treatment, the frequency of cardiovascular events was dependent on the disease complexity (event-free survival rates at 3 years were 85%, 65%, and 58%, respectively). The hazard ratios were 4.0 and 5.1 in the moderate and complex groups, respectively. With the exception of scheduled transcatheter intervention, cardiovascular events were strongly related to the disease complexity of original heart disease. However, cardiovascular events were not rare even in the simple ACHD group.
キーワード congenital heart defect congenital in adults hospitalization cardiovascular event
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-08
巻 73巻
号 4号
出版者 Okayama University Medical School
開始ページ 307
終了ページ 313
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31439953
JaLCDOI 10.18926/AMO/56931
フルテキストURL 73_4_299.pdf
著者 Hiranaka, Takaaki| Nishida, Keiichiro| Konishiike, Taizo| Ozaki, Toshifumi| Mikasa, Motohiko|
抄録 The fixation technique of bony fragments is crucial for the bone union of the tuberosities after humeral head replacement (HHR) for a comminuted fracture of the proximal humerus. To increase the bone union rate, we reduce tuberosities to overlap on the humeral shaft by approx. 1 cm and fix them with cable wire. Herein, we retrospectively investigated the clinical and radiographic outcomes of our procedure. Twenty-six patients who underwent cementless HHR for the treatment of comminuted fractures of the proximal humerus were investigated. The Constant-Murley score, active shoulder mobility, and bone union rate were evaluated. The mean duration of follow-up was 56.3 months (range 24-197). At the final follow-up, the average Constant-Murley score was 58 (range 40-76). Forward elevation was 126° on average (range 35°-180°). Twenty-three cases (88%) showed bone union between the tuberosities and the shaft at an average follow-up of 4.1 months (range 4-5 months) after surgery. Non-union was noted in 1 case, and bone resorption was noted in 2 cases. The bone union rate and the clinical outcome of our procedure were relatively favorable
キーワード humeral head replacement tuberosity-overlapping technique bone union of tuberosities cable wire cementless stem
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-08
巻 73巻
号 4号
出版者 Okayama University Medical School
開始ページ 299
終了ページ 305
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31439952
JaLCDOI 10.18926/AMO/56930
フルテキストURL 73_4_285.pdf
著者 Otani, Yoshihiro| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Date, Isao|
抄録 Gliomas are characterized as highly diffuse infiltrating tumors, and currently available treatments such as surgery, radiation and chemotherapy are unfeasible or show limited efficacy against these tumors. Recent genetic and epigenetic analyses of glioma have revealed increasing evidence of the role of driver genetic alterations in glioma development and led to the identification of prognostic factors. Despite these findings, the survival rates of glioma patients remain low, and alternative treatments and novel targets are needed. Recent studies identified neural stem cells as the possible origin of gliomas, and some evidence has revealed shared functions and mechanisms between glioma cells and neurons, also supporting their similarity. The cytoskeleton plays important roles in the migration of normal cells as well as cancer cells. Recent reports have described a role for microtubules, a component of the cytoskeleton, in glioma invasion. Notably, several factors that regulate microtubule functions, such as microtubule-associated proteins, plus-end tracking proteins, or motor proteins, are upregulated in glioma tissues compared with normal tissue, and upregulation of these factors is associated with high invasiveness of glioma cells. In this review, we describe the mechanism of microtubules in glioma invasion and discuss the possibility of microtubule-targeted therapy to inhibit glioma invasion.
キーワード glioma cytoskeletons invasion microtubules
Amo Type Review
出版物タイトル Acta Medica Okayama
発行日 2019-08
巻 73巻
号 4号
出版者 Okayama University Medical School
開始ページ 285
終了ページ 297
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31439951
JaLCDOI 10.18926/bgeou/56920
タイトル(別表記) Arguments over the Educational Role of Teachers in Moral Classes in the 1950-70’s
フルテキストURL bgeou_171_013_022.pdf
著者 小林 万里子|
抄録  「道徳の時間」成立後に提唱された授業論において,教師と子ども(たち)の関係がどのように語られてきたかを整理し,次第に教師の指導性が前景化する様相を描き出した。1958 年ならびに1969・70 年の学習指導要領および指導書では「道徳の時間」特設前から重視された「子どもに寄り添う」教師像に加えて「子どもとともに学ぶ」「子どもたちの関係をつくる」教師像が提示された。これらの教師像を前提としつつ,道徳授業論においては「子どもたちの学習の道筋をつくる」という教師の役割が強調されたことが明らかになった。
キーワード 道徳の時間 道徳授業論 教師の主体性 子どもの主体性
出版物タイトル 岡山大学大学院教育学研究科研究集録
発行日 2019-07-26
巻 171巻
開始ページ 13
終了ページ 22
ISSN 1883-2423
言語 日本語
論文のバージョン publisher
NAID 120006711413
ファイルURL 04631kogomemizu.jpg k-kogomemizu.jpg
APG3科 イラクサ科 (Urticaceae)
YList ylist.info/ylist_detail_display.php?pass=2561
データベース 日本の雑草 種子画像データデース
データベース(別表記) Naturalized plants in Japan : Seed-Image database
公開者 岡山大学 資源植物科学研究所 野生植物グループ
資料タイプ データ・データベース
公式URL http://www.rib.okayama-u.ac.jp/wild/okayama_kika_v2/Seed-image-database-J.html|
JaLCDOI 10.18926/OER/56912
タイトル(別表記) J. H. Clapham, An Economic History of Modern Britain, vol. 3, Machines and National Rivalries (1887-1914), with an Epilogue (1914-1929), Outline, Chap.8
フルテキストURL oer_051_1_059_083.pdf
著者 一ノ瀬 篤|
出版物タイトル 岡山大学経済学会雑誌
発行日 2019-07-16
巻 51巻
号 1号
開始ページ 59
終了ページ 83
ISSN 2433-4146
言語 日本語
著作権者 Copyright © 2019 岡山大学経済学会
論文のバージョン publisher
NAID 120006652411
JaLCDOI 10.18926/OER/56911
フルテキストURL oer_051_1_035_058.pdf
著者 松尾 展成|
出版物タイトル 岡山大学経済学会雑誌
発行日 2019-07-16
巻 51巻
号 1号
開始ページ 35
終了ページ 58
ISSN 2433-4146
言語 日本語
著作権者 Copyright © 2019 岡山大学経済学会
論文のバージョン publisher
NAID 120006652410
JaLCDOI 10.18926/OER/56910
タイトル(別表記) The Japan-China Economic Relations in GVC from the Perspective of Trade in Value Added: Using Japan-China GVC input-output table
フルテキストURL oer_051_1_019_034.pdf
著者 滕 鑑| 馮 君実|
出版物タイトル 岡山大学経済学会雑誌
発行日 2019-07-16
巻 51巻
号 1号
開始ページ 19
終了ページ 34
ISSN 2433-4146
言語 日本語
著作権者 Copyright © 2019 岡山大学経済学会
論文のバージョン publisher
NAID 120006652409