検索結果 - 岡山大学学術成果リポジトリ

Recent advances in radiotracers targeting norepinephrine transporter: structural development and radiolabeling improvements

フルテキストURL	fulltext.pdf
著者	Chen, Xinyu\| Kudo, Takashi\| Lapa, Constantin\| Buck, Andreas\| Higuchi, Takahiro\|
キーワード	Norepinephrine transporter Benzylguanidine Phenethylguanidine Antidepressant Organic cation transporter
発行日	2020-04-09
出版物タイトル	Journal of Neural Transmission
巻	127巻
号	6号
出版者	Springer
開始ページ	851
終了ページ	873
ISSN	0300-9564
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	Author(s)
論文のバージョン	author
PubMed ID	32274584
DOI	10.1007/s00702-020-02180-4
Web of Science KeyUT	000535371000001
関連URL	isVersionOf https://doi.org/10.1007/s00702-020-02180-4

Adult T-cell Leukemia-lymphoma with Primary Breast Involvement: A Case Report and Literature Review

著者	Kobayashi, Hiroki\| Asada, Noboru\| Igawa, Takuro\| Abe, Masaya\| Meguri, Yusuke\| Ennishi, Daisuke\| Nishimori, Hisakazu\| Fujii, Nobuharu\| Matsuoka, Ken-ichi\| Yoshino, Tadashi\| Maeda, Yoshinobu\|
キーワード	adult T-cell leukemia-lymphoma breast involvement positron emission tomography/computed tomography
発行日	2020-11-01
出版物タイトル	Internal Medicine
巻	59巻
号	21号
出版者	日本内科学会
開始ページ	2757
終了ページ	2761
ISSN	0918-2918
NCID	AA10827774
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 by The Japanese Society of Internal Medicine
論文のバージョン	publisher
DOI	10.2169/internalmedicine.5077-20
関連URL	isVersionOf https://doi.org/10.2169/internalmedicine.5077-20

Marked Reduction of Pulmonary Artery Pressure After Registration for Lung Transplantation Is Associated With Long-Term Survival in Patients With Pulmonary Arterial Hypertension　― Cohort Study ―

フルテキストURL	fulltext.pdf
著者	Akagi, Satoshi\| Matsubara, Hiromi\| Nakamura, Kazufumi\| Oto, Takahiro\| Ejiri, Kentaro\| Ito, Hiroshi\|
キーワード	Lung transplantation Pulmonary artery hypertension Pulmonary artery pressure Survival
発行日	2020-01-24
出版物タイトル	Circulation Journal
巻	84巻
号	2号
出版者	The Japanese Circulation Society
開始ページ	245
終了ページ	251
ISSN	1346-9843
NCID	AA11591968
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
論文のバージョン	publisher
DOI	10.1253/circj.CJ-19-0784
関連URL	isVersionOf https://doi.org/10.1253/circj.CJ-19-0784

Alteration of chemokine production in bovine endometrial epithelial and stromal cells under heat stress conditions

フルテキストURL	fulltext.pdf
著者	Sakai, Shunsuke\| Hatabu, Toshimitsu\| Yamamoto, Yuki\| Kimura, Koji\|
キーワード	chemokine cow endometrial cells endometritis heat stress
発行日	2020-11-23
出版物タイトル	Physiological Reports
巻	8巻
号	22号
出版者	Wiley
開始ページ	e14640
ISSN	2051-817X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 The Authors.
論文のバージョン	publisher
PubMed ID	33230953
DOI	10.14814/phy2.14640
Web of Science KeyUT	000596091500001
関連URL	isVersionOf https://doi.org/10.14814/phy2.14640

Postharvest Properties of Ultra-Late Maturing Peach Cultivars and Their Attributions to Melting Flesh (M) Locus: Re-evaluation of M Locus in Association With Flesh Texture

フルテキストURL	fulltext.pdf
著者	Nakano, Ryohei\| Kawai, Takashi\| Fukamatsu, Yosuke\| Akita, Kagari\| Watanabe, Sakine\| Asano, Takahiro\| Takata, Daisuke\| Sato, Mamoru\| Fukuda, Fumio\| Ushijima, Koichiro\|
キーワード	fruit softening ethylene Prunus persica melting flesh locus endoPG postharvest
発行日	2020-11-26
出版物タイトル	Frontiers in Plant Science
巻	11巻
出版者	Frontiers Media
開始ページ	554158
ISSN	1664-462X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 Nakano, Kawai, Fukamatsu, Akita, Watanabe, Asano, Takata, Sato, Fukuda and Ushijima.
論文のバージョン	publisher
PubMed ID	33324428
DOI	10.3389/fpls.2020.554158
Web of Science KeyUT	000596841900001
関連URL	isVersionOf https://doi.org/10.3389/fpls.2020.554158

Cardiosphere-derived exosomal microRNAs for myocardial repair in pediatric dilated cardiomyopathy

フルテキストURL	fulltext.pdf
著者	Hirai, Kenta\| Ousaka, Daiki\| Fukushima, Yosuke\| Kondo, Maiko\| Eitoku, Takahiro\| Shigemitsu, Yusuke\| Hara, Mayuko\| Baba, Kenji\| Iwasaki, Tatsuo\| Kasahara, Shingo\| Ohtsuki, Shinichi\| Oh, Hidemasa\|
備考	This is the author's version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science Translational Medicine on 573(12), 2020, DOI: 10.1126/scitranslmed.abb3336.\|
発行日	2020-12-09
出版物タイトル	Science Translational Medicine
巻	12巻
号	573号
出版者	American Association for the Advancement of Science
開始ページ	eabb3336
ISSN	1946-6234
NCID	AA12519139
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Authors
論文のバージョン	author
PubMed ID	33298561
DOI	10.1126/scitranslmed.abb3336
Web of Science KeyUT	000597340700004
関連URL	isVersionOf https://doi.org/10.1126/scitranslmed.abb3336

Inhibition of interleukin-6 signaling attenuates aortitis, left ventricular hypertrophy and arthritis in interleukin-1 receptor antagonist deficient mice

フルテキストURL	fulltext.pdf
著者	Hada, Yoshiko\| Uchida, Haruhito A.\| Mukai, Tomoyuki\| Kojima, Fumiaki\| Yoshida, Masashi\| Takeuchi, Hidemi\| Kakio, Yuki\| Otaka, Nozomu\| Morita, Yoshitaka\| Wada, Jun\|
キーワード	MR16-1 interleukin-1 receptor antagonist aortitis arthritis LV hypertrophy
備考	This is an accepted version of Yoshiko Hada et. al. Inhibition of interleukin-6 signaling attenuates aortitis, left ventricular hypertrophy and arthritis in interleukin-1 receptor antagonist deficient mice published in Clinical Science 134(20). For final published version, see https://doi.org/10.1042/CS20201036.\|
発行日	2020-10-30
出版物タイトル	Clinical Science
巻	134巻
号	20号
出版者	Portland Press
開始ページ	2771
終了ページ	2787
ISSN	0143-5221
NCID	AA00143386
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© Authors
論文のバージョン	author
PubMed ID	33064141
DOI	10.1042/CS20201036
Web of Science KeyUT	000587350600004
関連URL	isVersionOf https://doi.org/10.1042/CS20201036

A novel model of liver cancer stem cells developed from induced pluripotent stem cells

フルテキストURL	fulltext.pdf
著者	Afify, Said M.\| Calle, Anna Sanchez\| Hassan, Ghmkin\| Kumon, Kazuki\| Nawara, Hend M.\| Zahra, Maram H.\| Mansour, Hager M.\| Khayrani, Apriliana Cahya\| Alam, Md Jahangir\| Du, Juan\| Seno, Akimasa\| Iwasaki, Yoshiaki\| Seno, Masaharu\|
キーワード	Cancer models Cancer stem cells
発行日	2020-03-17
出版物タイトル	British Journal of Cancer
巻	122巻
号	9号
出版者	Springer Nature
開始ページ	1378
終了ページ	1390
ISSN	0007-0920
NCID	AA00574355
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© Authors
論文のバージョン	publisher
PubMed ID	32203212
DOI	10.1038/s41416-020-0792-z
Web of Science KeyUT	000519841900001
関連URL	isVersionOf https://doi.org/10.1038/s41416-020-0792-z

A New Serum Biomarker Set to Detect Mild Cognitive Impairment and Alzheimer’s Disease by Peptidome Technology

フルテキストURL	fulltext.pdf
著者	Abe, Koji\| Shang, Jingwei\| Shi, Xiaowen\| Yamashita, Toru\| Hishikawa, Nozomi\| Takemoto, Mami\| Morihara, Ryuta\| Nakano, Yumiko\| Ohta, Yasuyuki\| Deguchi, Kentaro\| Ikeda, Masaki\| Ikeda, Yoshio\| Okamoto, Koichi\| Shoji, Mikio\| Takatama, Masamitsu\| Kojo, Motohisa\| Kuroda, Takeshi\| Ono, Kenjiro\| Kimura, Noriyuki\| Matsubara, Etsuro\| Osakada, Yosuke\| Wakutani, Yosuke\| Takao, Yoshiki\| Higashi, Yasuto\| Asada, Kyoichi\| Senga, Takehito\| Lee, Lyang-Ja\| Tanaka, Kenji\|
キーワード	Alzheimer’s disease biomarker coagulation complement MALDI-TOF mild cognitive impairment neuroinflammation peptidome plasticity
発行日	2020-01-07
出版物タイトル	Journal of Alzheimer's Disease
巻	73巻
号	1号
出版者	IOP Press
開始ページ	217
終了ページ	227
ISSN	1387-2877
NCID	AA11545428
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 - IOS Press and the authors.
論文のバージョン	publisher
PubMed ID	31771070
DOI	10.3233/JAD-191016
Web of Science KeyUT	000506311500018
関連URL	isVersionOf https://content.iospress.com/articles/journal-of-alzheimers-disease/jad191016

For Vol.74, No.5 pp443-448 Combined Laparoscopic and CT Monitoring of the Ice-Ball Margin during Cryoablation for Renal Cell Carcinoma Associated with von Hippel-Lindau Disease: First Case

フルテキストURL	74_6_563.pdf
Amo Type	Erratum
出版物タイトル	Acta Medica Okayama
発行日	2020-12
巻	74巻
号	6号
出版者	Okayama University Medical School
開始ページ	563
終了ページ	563
ISSN	0386-300X
NCID	AA00508441
資料タイプ	その他
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	33361879
Web of Science KeyUT	000601203600015

Antioxidative attributes of rice bran extracts in ameliorative effects of atherosclerosis-associated risk factors

著者	Xian, Wen Tan\| Kobayashi, Kazuko\| Lianhua, Shen\| Inagaki, Junko\| Ide, Masahiro\| Hwang, Siaw San\| Matsuura, Eiji\|
キーワード	Food science Food analysis Rice bran extract (RBE) Functional food Phytochemicals Atherosclerosis Oxidative stress Inflammation Antioxidant Anti-inflammation Oxidized lipoprotein (oxLDL)
発行日	2020-12
出版物タイトル	Heliyon
巻	6巻
号	12号
出版者	Elsevier
開始ページ	e05743
ISSN	2405-8440
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2020 The Authors.
論文のバージョン	publisher
DOI	10.1016/j.heliyon.2020.e05743
関連URL	isVersionOf https://doi.org/10.1016/j.heliyon.2020.e05743

A Japanese Patient with Gastric Cancer and Dihydropyrimidine Dehydrogenase Deficiency Presenting with DPYD Variants

JaLCDOI	10.18926/AMO/61217
フルテキストURL	74_6_557.pdf
著者	Ishiguro, Mikako\| Takenaka, Ryuta\| Ogura, Kenichiro\| Hiratsuka, Akira\| Takeda, Hiromasa\| Kawai, Daisuke\| Tsugeno, Hirofumi\| Fujiki, Shigeatsu\| Okada, Hiroyuki\|
抄録	A 63-year-old Japanese male with stomach adenocarcinoma received oral 5-fluorouracil derivative, cisplatin and trastuzumab chemotherapy. On day 8, severe diarrhea and mucositis developed; chemotherapy was stopped. On day 14, the patient developed renal dysfunction and febrile neutropenia. He also suffered from pneumonia due to Candida albicans. Systemic symptoms improved after intensive conservative treatment. Best supportive care was continued until the patient died from gastric cancer. The dihydropyrimidine dehydroge-nase protein level was low at 3.18 U/mg protein. The result of DPYD genotyping revealed three variants at posi-tions 1615 (G > A), 1627 (A > G), and 1896 (T > C) in exons 13, 13, and 14, respectively.
キーワード	5-fluorouracil dihydropyrimidine dehydrogenase deficiency DPYD variant gastric cancer
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2020-12
巻	74巻
号	6号
出版者	Okayama University Medical School
開始ページ	557
終了ページ	562
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	33361878
Web of Science KeyUT	000601203600014
NAID	120006948944

C-Arm-Free Minimally Invasive Cervical Pedicle Screw Fixation (MICEPS): A Technical Note

JaLCDOI	10.18926/AMO/61216
フルテキストURL	74_6_551.pdf
著者	Tanaka, Masato\| Fujiwara, Yoshihiro\| Uotani, Koji\| Kadiri, Venkatesh\| Yamauchi, Taro\|
抄録	A minimally invasive posterolateral approach designed to avoid the lateral misplacement of midcervical pedicle screws was reported, but there is no technical report that describes this technique without C-arm fluoroscopy. We report the results of a 2.5 years follow-up of a 62-year-old female patient with C4 metastatic breast cancer. The patient suffered from severe neck pain and impending quadriplegia for 2 months after radiation therapy. We performed C-arm-free minimally invasive cervical pedicle screw fixation (MICEPS). The patient was suc-cessfully treated with surgery, and her neck pain was well controlled. She had neither neurological deficits nor neck pain at the final (2.5-year) follow-up. C-arm-free MICEPS is a useful technique; in addition, the sur-geons and staff have no risk of radiation exposure, there is a reduced need for postoperative imaging, and a decreased revision rate can be expected with C-arm-free MICEPS.
キーワード	cervical spine navigation surgery minimally invasive surgery cervical pedicle screw C-arm free
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2020-12
巻	74巻
号	6号
出版者	Okayama University Medical School
開始ページ	551
終了ページ	556
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	33361877
Web of Science KeyUT	000601203600013
NAID	120006948943

Delayed Methotrexate Elimination after Administration of a Medium Dose of Methotrexate in a Patient with Genetic Variants Associated with Methotrexate Clearance

JaLCDOI	10.18926/AMO/61215
フルテキストURL	74_6_545.pdf
著者	Tatebe, Yasuhisa\| Kanamitsu, Kiichiro\| Kanzaki, Hirotaka\| Ishida, Hisashi\| Fujiwara, Kaori\| Washio, Kana\| Kitamura, Yoshihisa\| Sendo, Toshiaki\| Shimada, Akira\| Tsukahara, Hirokazu\|
抄録	Polymorphisms in methotrexate transporter pathways have been associated with methotrexate toxicities and clearance. Recent genome-wide association studies have revealed that the SLCO1B1 T521C variant is associated with methotrexate elimination. We present a case of a pediatric patient with acute lymphoblastic leukemia who suffered from persistently high plasma methotrexate concentrations and acute kidney injuries after the admin-istration of a medium dose of methotrexate. Subsequent genetic analysis showed that he was a carrier of dys-functional genetic variants associated with methotrexate clearance. This case highlights that polymorphisms of methotrexate transporter pathways can adversely affect methotrexate elimination in a clinically significant manner.
キーワード	methotrexate polymorphism drug elimination acute kidney injury acute lymphoblastic leukemia
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2020-12
巻	74巻
号	6号
出版者	Okayama University Medical School
開始ページ	545
終了ページ	550
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	33361876
Web of Science KeyUT	000601203600012
NAID	120006948942

Four Cases with Rare Complications of Intramedullary Screw Fixation for Jones Fracture

JaLCDOI	10.18926/AMO/61214
フルテキストURL	74_6_537.pdf
著者	Morimoto, Yusuke\| Komatsu, Taichi\| Tokuhashi, Yasuaki\|
抄録	Active treatment with intramedullary screw fixation is now common for athletes with Jones fracture. Outcomes are generally good, but complications can occur. We report 4 rare complications of intramedullary screw fixa-tion. Two cases developed osteomyelitis and pseudarthrosis caused by thermal necrosis. In the other two cases, screw-related complications occurred during the insertion of the tapered headless screw. Although thermal necrosis and screw insertion failures are considered rare complications and not widely reported in the litera-ture, they do occur occasionally. Knowing the mechanisms underlying these complications could help prevent them, and knowing their course could lead caregivers to appropriate interventions when they do occur.
キーワード	Jones fracture thermal necrosis tapered headless screw
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2020-12
巻	74巻
号	6号
出版者	Okayama University Medical School
開始ページ	537
終了ページ	544
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	33361875
Web of Science KeyUT	000601203600011
NAID	120006948953

Soft Tissue Myoepithelioma of the Shoulder

JaLCDOI	10.18926/AMO/61213
フルテキストURL	74_6_531.pdf
著者	Hashimoto, Kazuhiko\| Nishimura, Shunji\| Chikugo, Takaaki\| Kakinoki, Ryosuke\| Akagi, Masao\|
抄録	Soft tissue myoepitheliomas are often misdiagnosed due to their rarity. Herein, we describe a case of soft tissue myoepithelioma of the shoulder. A 72-year-old woman had a suspected sarcoma on her shoulder and under-went open biopsy. She was referred to our hospital, where the tumor was widely resected and the diagnosis of myoepithelioma was histologically confirmed. No recurrence has been observed in the 3 years since the sur-gery. Careful and prompt planning is necessary for the effective treatment of myoepithelioma.
キーワード	soft tissue myoepithelioma unplanned resection shoulder
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2020-12
巻	74巻
号	6号
出版者	Okayama University Medical School
開始ページ	531
終了ページ	535
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	33361874
Web of Science KeyUT	000601203600010
NAID	120006948952

Solitary Cardiac Metastasis of Hepatocellular Carcinoma

JaLCDOI	10.18926/AMO/61212
フルテキストURL	74_6_525.pdf
著者	Aoki, Hideki\| Utsumi, Masashi\| Kimura, Yuji\| Takahashi, Yosuke\| Nagahisa, Seiichi\| Nishimura, Seitaro\| Une, Yuta\| Watanabe, Megumi\| Taniguchi, Fumitaka\| Arata, Takashi\| Katsuda, Koh\| Tanakaya, Kohji\|
抄録	Cardiac metastasis originating from hepatocellular carcinoma (HCC) is a rare condition with a poor prognosis. No therapeutic standards for cardiac metastasis originating from HCC have been established. At 19 months after a curative hepatectomy, a 64-year-old Japanese hepatitis B virus-positive male patient experienced solitary cardiac metastasis originating from HCC. The cardiac tumor was discovered in the right ventricle. The patient received three courses of radiotherapy and chemotherapy and survived > 3 years after the initial diagnosis of cardiac metastasis. His case demonstrates that radiotherapy combined with chemotherapy can be an effective treatment for cardiac metastasis.
キーワード	hepatocellular carcinoma cardiac metastasis radiotherapy chemotherapy
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2020-12
巻	74巻
号	6号
出版者	Okayama University Medical School
開始ページ	525
終了ページ	530
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	33361873
Web of Science KeyUT	000601203600009
NAID	120006948951

Antenatal Care Visits and Adverse Pregnancy Outcomes at a Hospital in Rural Western Province, Rwanda

JaLCDOI	10.18926/AMO/61209
フルテキストURL	74_6_495.pdf
著者	Calliope, Simba Akintije\| Yorifuji, Takashi\| Wada, Takayuki\| Mukakarake, Marie Goret\| Mutesa, Leon\| Yamamoto, Taro\|
抄録	In many economically developing countries, and especially in the rural regions of sub-Saharan African coun-tries, there have been only limited investigations into the association between antenatal care (ANC) and adverse pregnancy outcomes. We obtained information on ANC and pregnancy outcomes between 2011 and 2016 from hospital files of pregnant women (n = 4,960) served at a rural hospital in Rwanda, and we examined the associa-tions between their ANC visits and the adverse pregnancy and neonatal outcomes by using univariate and mul-tivariate logistic regression models to estimate the odds ratios (ORs) and 95% confidence intervals (CIs). Most of the pregnant women had ≥ 4 ANC visits, but 39% (n = 1,911) did not have ≥ 3 visits before delivery. The prev-alence of low birth weight (LBW) and that of preterm birth (PTB) were 12% and 9.9%, respectively. Compared to the women who attended only one ANC visit, those who attended ≥ 4 ANC visits had lower risks of LBW (OR 0.20; 95%CI: 0.11-0.36) and PTB (OR 0.28; 95%CI: 0.11-0.76). Frequent ANC visits were also associ-ated with better postnatal outcomes of the newborns. Encouraging women to attend ANC visits before delivery can markedly reduce PTB-related and LBW-related complications, especially in resource-limited settings.
キーワード	antenatal care epidemiology low birth weight preterm birth rural
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-12
巻	74巻
号	6号
出版者	Okayama University Medical School
開始ページ	495
終了ページ	503
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	33361869
Web of Science KeyUT	000601203600005
NAID	120006948958

Potential of Artificial Intelligence for Estimating Japanese Fetal Weights

JaLCDOI	10.18926/AMO/61207
フルテキストURL	74_6_483.pdf
著者	Miyagi, Yasunari\| Miyake, Takahito\|
抄録	We developed an artificial intelligence (AI) method for estimating fetal weights of Japanese fetuses based on the gestational weeks and the bi-parietal diameter, abdominal circumference, and femur length. The AI comprised of neural network architecture was trained by deep learning with a dataset that consists of ± 2 standard devia-tion (SD), ± 1.5SD, and ± 0SD categories of the approved standard values of ultrasonic measurements of the fetal weights of Japanese fetuses (Japan Society of Ultrasonics in Medicine [JSUM] data). We investigated the residuals and compared 2 other regression formulae for estimating the fetal weights of Japanese fetuses by t-test and Bland-Altman analyses, respectively. The residuals of the AI for the test dataset that was 12.5% of the JSUM data were 6.4 ± 2.6, −3.8 ± 8.6, and −0.32 ± 6.3 (g) at −2SD, +2SD, and all categories, respectively. The residu-als of another AI method created with all of the JSUM data, of which 20% were randomized validation data, were −1.5 ± 9.4, −2.5 ± 7.3, and −1.1 ± 6.7 (g) for −2SD, +2SD, and all categories, respectively. The residuals of this AI were not different from zero, whereas those of the published formulae differed from zero. Though vali-dation is required, the AI demonstrated potential for generating fetal weights accurately, especially for extreme fetal weights.
キーワード	deep learning artificial intelligence fetal weight neural network ultrasound biometry
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-12
巻	74巻
号	6号
出版者	Okayama University Medical School
開始ページ	483
終了ページ	493
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	33361868
Web of Science KeyUT	000601203600004
NAID	120006948957

Clinical Application of the Ratio of Serum Bone Isoform to Total Alkaline Phosphatase in General Practice

JaLCDOI	10.18926/AMO/61205
フルテキストURL	74_6_467.pdf
著者	Yokota, Yuya\| Nishimura, Yoshito\| Ando, Akemi\| Hanayama, Yoshihisa\| Hasegawa, Kou\| Hagiya, Hideharu\| Ogawa, Hiroko\| Obika, Mikako\| Ueda, Keigo\| Otsuka, Fumio\|
抄録	Alkaline phosphatase (ALP) is an enzyme that is expressed in a variety of tissues. Among the isoforms of ALP, bone-specific alkaline phosphatase (BAP) is used as a marker for evaluating bone metabolism. We investigated the clinical usefulness of the ratio of serum BAP to total ALP for the diagnosis of various disorders in general practice. We retrospectively analyzed the cases of 107 Japanese patients whose serum BAP levels were exam-ined, focusing on clinical characteristics. We observed that the BAP/ALP ratios of the patients with fever and those with inflammatory diseases were significantly lower than the ratios of other patient groups. The BAP/ALP ratios of the patients with osteoporosis and those with metabolic bone diseases were higher than those of the patients with other conditions. The BAP/ALP ratio was found to be negatively correlated with age, a cor-relation that has not been found in other ethnicities. The serum BAP/ALP ratio was inversely correlated with serum CRP levels but was positively correlated with serum albumin levels and hemoglobin concentrations. Collectively, our results suggest that the BAP/ALP ratio could be a useful predictor for important geriatric con-ditions seen in general practice.
キーワード	alkaline phosphatase BAP CRP inflammation osteoporosis
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2020-12
巻	74巻
号	6号
出版者	Okayama University Medical School
開始ページ	467
終了ページ	474
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2020 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	33361866
Web of Science KeyUT	000601203600002
NAID	120006948955