
検索結果 984 件
| JaLCDOI | 10.18926/AMO/64035 |
|---|---|
| フルテキストURL | 76_5_541.pdf |
| 著者 | Akebi, Toru| Matsugaki, Ryutaro| Ono, Toshiro| |
| 抄録 | The purpose of this study was to conduct a self-reported questionnaire survey of work-related musculoskeletal disorders (WMSDs) among Japanese radiological technologists (RTs) and to report on the relationship between wearing a lead apron and WMSDs. Between February and April of 2021, RTs in Okayama Prefecture, Japan, were surveyed by mail and through a website. Information on individual characteristics, physical factors at work, and the presence of WMSDs were collected. All participants were also asked whether they frequently wore lead aprons. A multiple logistic regression analysis was used to assess the relationship between wearing a lead apron and WMSDs. The model was adjusted for age, sex, body mass index (BMI), and working hours. Of the 123 participants, 67 (54.5%) had WMSDs. Multiple logistic regression analysis revealed that WMSDs were significantly associated with wearing a lead apron. Compared to the “Never wear” group, the odds ratios for the “Always/Frequently wear” and “Sometimes/Rarely wear” groups were 7.87 (95% confidence interval [CI]=1.28-48.46; p=0.026) and 7.80 (95% CI=1.43-42.44; p=0.017), respectively. Our analysis suggests that wearing a lead apron is associated with WMSDs, and thus design modifications in lead aprons may improve the occupational health management of RTs. |
| キーワード | work-related musculoskeletal disorders radiological technologists lead apron questionnaire survey multiple logistic regression analysis |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-10 |
| 巻 | 76巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 541 |
| 終了ページ | 545 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36352801 |
| Web of Science KeyUT | 000884907100007 |
| JaLCDOI | 10.18926/AMO/64025 |
|---|---|
| フルテキストURL | 76_5_503.pdf |
| 著者 | Ogawa, Hirohito| Honda, Tomoyuki| |
| 抄録 | Eukaryotic genomes contain numerous copies of endogenous viral elements (EVEs), most of which are considered endogenous retrovirus (ERV) sequences. Over the past decade, non-retroviral endogenous viral elements (nrEVEs) derived from ancient RNA viruses have been discovered. Several functions have been proposed for these elements, including antiviral defense. This review summarizes the current understanding of nrEVEs derived from RNA viruses, particularly endogenous bornavirus-like elements (EBLs) and endogenous filovirus-like elements (EFLs). EBLs are one of the most extensively studied nrEVEs. The EBL derived from bornavirus nucleoprotein (EBLN) is thought to function as a non-coding RNA or protein that regulates host gene expression or inhibits virus propagation. Ebolavirus and marburgvirus, which are filoviruses, induce severe hemorrhagic fever in humans and nonhuman primates. Although the ecology of filoviruses remains unclear, bats are believed to be potential reservoirs. Based on the knowledge from EBLs, it is postulated that EFLs in the bat genome help to maintain the balance between filovirus infection and the bat’s defense system, which may partially explain why bats act as potential reservoirs. Further research into the functions of nrEVEs could reveal novel antiviral systems and inspire novel antiviral approaches. |
| キーワード | EVE nrEVE bornavirus filovirus antiviral |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-10 |
| 巻 | 76巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 503 |
| 終了ページ | 510 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36352796 |
| Web of Science KeyUT | 000884907100002 |
| JaLCDOI | 10.18926/AMO/64024 |
|---|---|
| フルテキストURL | 76_5_489.pdf |
| 著者 | Matsumoto, Yuji| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Date, Isao| |
| 抄録 | Glioblastoma (GBM) is a fatal primary malignant brain tumor in adults. Despite decades of research, the prognosis for GBM patients is still disappointing. One major reason for the intense therapeutic resistance of GBM is inter- and intra-tumor heterogeneity. GBM-intrinsic transcriptional profiling has suggested the presence of at least three subtypes of GBM: the proneural, classic, and mesenchymal subtypes. The mesenchymal subtype is the most aggressive, and patients with the mesenchymal subtype of primary and recurrent tumors tend to have a worse prognosis compared with patients with the other subtypes. Furthermore, GBM can shift from other subtypes to the mesenchymal subtype over the course of disease progression or recurrence. This phenotypic transition is driven by diverse tumor-intrinsic molecular mechanisms or microenvironmental factors. Thus, better understanding of the plastic nature of mesenchymal transition in GBM is pivotal to developing new therapeutic strategies. In this review, we provide a comprehensive overview of the current understanding of the elements involved in the mesenchymal transition of GBM and discuss future perspectives. |
| キーワード | glioma glioblastoma mesenchymal subtype mesenchymal transition heterogeneity |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-10 |
| 巻 | 76巻 |
| 号 | 5号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 489 |
| 終了ページ | 502 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36352795 |
| Web of Science KeyUT | 000884907100001 |
| フルテキストURL | fulltext20221026-3.pdf |
|---|---|
| 著者 | Honda, Yasuko| |
| キーワード | Community renewable energy rural community local initiative Japan Agricultural Cooperatives energy cooperative |
| 備考 | Journal of Asian Rural Studies, 2021, 5(1): 63-77| |
| 発行日 | 2021-3-26 |
| 出版物タイトル | Journal of Asian Rural Studies |
| 巻 | 5巻 |
| 号 | 1号 |
| 出版者 | Hasanuddin University and Asian Rural Sociology Association |
| 開始ページ | 63 |
| 終了ページ | 77 |
| ISSN | 2548-3269 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 論文のバージョン | publisher |
| DOI | 10.20956/jars.v5i1.2656 |
| 関連URL | isVersionOf https://doi.org/10.20956/jars.v5i1.2656 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Hagiya, Hideharu| Takase, Ryosuke| Honda, Hiroyuki| Nakano, Yasuhiro| Otsuka, Yuki| Kataoka, Hitomi| Uno, Mika| Ueda, Keigo| Takahashi, Misa| Ogawa, Hiroko| Hanayama, Yoshihisa| Otsuka, Fumio| |
| キーワード | Traffic safety Older people Aging Motor vehicle accidents Frailty Dementia Polypharmacy Sarcopenia |
| 発行日 | 2022-10-11 |
| 出版物タイトル | BMC Geriatrics |
| 巻 | 22巻 |
| 号 | 1号 |
| 出版者 | BMC |
| 開始ページ | 792 |
| ISSN | 1471-2318 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2022. |
| 論文のバージョン | publisher |
| PubMed ID | 36221051 |
| DOI | 10.1186/s12877-022-03490-w |
| Web of Science KeyUT | 000866114200002 |
| 関連URL | isVersionOf https://doi.org/10.1186/s12877-022-03490-w |
| フルテキストURL | e105-b_9_1087.pdf |
|---|---|
| 著者 | DENNO, Satoshi| HOU, Yafei| |
| 備考 | Satoshi DENNO, Yafei HOU, Asynchronous Periodic Interference Signals Cancellation in Frequency Domain, IEICE Transactions on Communications, 2022, Volume E105.B, Issue 9, Pages 1087-1096| |
| 発行日 | 2022-9-1 |
| 出版物タイトル | IEICE Transactions on Communications |
| 巻 | E105.B巻 |
| 号 | 9号 |
| 出版者 | Institute of Electronics, Information and Communications Engineers (IEICE) |
| 開始ページ | 1087 |
| 終了ページ | 1096 |
| ISSN | 0916-8516 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright(C)2022 The Institute of Electronics, Information and Communication Engineers |
| 論文のバージョン | publisher |
| DOI | 10.1587/transcom.2021ebp3187 |
| Web of Science KeyUT | 000852727800008 |
| 関連URL | isVersionOf https://doi.org/10.1587/transcom.2021ebp3187 |
| フルテキストURL | fulltext20221017-1.pdf |
|---|---|
| 著者 | NEO, Sakurako| TAKEMURA-UCHIYAMA, Iyo| UCHIYAMA, Jumpei| MURAKAMI, Hironobu| SHIMA, Ayaka| KAYANUMA, Hideki| YOKOYAMA, Taiki| TAKAGI, Satoshi| KANAI, Eiichi| HISASUE, Masaharu| |
| キーワード | bile bile microbiota gallbladder hospitalized dog laboratory dog |
| 発行日 | 2022 |
| 出版物タイトル | Journal of Veterinary Medical Science |
| 巻 | 84巻 |
| 号 | 7号 |
| 出版者 | Japanese Society of Veterinary Science |
| 開始ページ | 1019 |
| 終了ページ | 1022 |
| ISSN | 0916-7250 |
| NCID | AA10796138 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | ©2022 The Japanese Society of Veterinary Science |
| 論文のバージョン | publisher |
| PubMed ID | 35650165 |
| DOI | 10.1292/jvms.22-0090 |
| Web of Science KeyUT | 000862768300020 |
| 関連URL | isVersionOf https://doi.org/10.1292/jvms.22-0090 |
| フルテキストURL | fulltext20220920-1.pdf |
|---|---|
| 著者 | Takahashi, Yuiki| Baba, Masaaki| Enomoto, Katsunari| Hiramoto, Ayami| Iwakuni, Kana| Kuma, Susumu| Tobaru, Reo| Miyamoto, Yuki| |
| 発行日 | 2022-9-1 |
| 出版物タイトル | The Astrophysical Journal |
| 巻 | 936巻 |
| 号 | 2号 |
| 出版者 | American Astronomical Society |
| ISSN | 0004-637X |
| NCID | AA00553242 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022. The Author(s). |
| 論文のバージョン | publisher |
| DOI | 10.3847/1538-4357/ac87fb |
| Web of Science KeyUT | 000850350600001 |
| 関連URL | isVersionOf https://doi.org/10.3847/1538-4357/ac87fb |
| フルテキストURL | fulltext20220921-1.pdf |
|---|---|
| 著者 | Munene, Kwenga Ismael| Funabiki, Nobuo| Rahman, Md. Mahbubur| Briantoro, Hendy| Roy, Sujan Chandra| Kuribayashi, Minoru| |
| キーワード | Internet of Things WLAN partially overlapping channel access point transmission power channel bonding non-channel bonding throughput drop |
| 備考 | © 2022 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.iot.2022.100583] . | |
| 発行日 | 2022-11 |
| 出版物タイトル | Internet of Things |
| 巻 | 20巻 |
| 出版者 | Elsevier BV |
| 開始ページ | 100583 |
| ISSN | 2542-6605 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 Elsevier B.V. |
| 論文のバージョン | author |
| DOI | 10.1016/j.iot.2022.100583 |
| Web of Science KeyUT | 000841402900001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.iot.2022.100583 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Li, Chunning| Yoshimura, Teizo| Tian, Miao| Wang, Yuze| Kondo, Takamasa| Yamamoto, Ken-Ichi| Fujisawa, Masayoshi| Ohara, Toshiaki| Sakaguchi, Masakiyo| Matsukawa, Akihiro| |
| キーワード | Breast cancer Metastasis Exosomes Epithelial mesenchymal transition Tumor microenvironment |
| 発行日 | 2022-09-12 |
| 出版物タイトル | Breast Cancer Research |
| 巻 | 24巻 |
| 号 | 1号 |
| 出版者 | BMC |
| 開始ページ | 60 |
| ISSN | 1465-5411 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2022. |
| 論文のバージョン | publisher |
| PubMed ID | 36096830 |
| DOI | 10.1186/s13058-022-01557-5 |
| Web of Science KeyUT | 000853036400001 |
| 関連URL | isVersionOf https://doi.org/10.1186/s13058-022-01557-5 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Panduman, Yohanes Yohanie Fridelin| Funabiki, Nobuo| Puspitaningayu, Pradini| Kuribayashi, Minoru| Sukaridhoto, Sritrusta| Kao, Wen-Chung| |
| キーワード | Internet of Things server platform SEMAR IoT application system sensor MQTT REST API |
| 発行日 | 2022-08-26 |
| 出版物タイトル | Sensors |
| 巻 | 22巻 |
| 号 | 17号 |
| 出版者 | MDPI |
| 開始ページ | 6436 |
| ISSN | 1424-8220 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 36080895 |
| DOI | 10.3390/s22176436 |
| Web of Science KeyUT | 000851763000001 |
| 関連URL | isVersionOf https://doi.org/10.3390/s22176436 |
| JaLCDOI | 10.18926/AMO/63908 |
|---|---|
| フルテキストURL | 76_4_479.pdf |
| 著者 | Ogawa, Chikako| Hirasawa, Akira| Sogawa, Reimi| Hasuoka, Kayoko| Tomida, Shuta| Futagawa, Mashu| Urakawa, Yusaku| Kochi, Mariko| Yamamoto, Hideki| Nakamura, Keiichiro| Masuyama, Hisashi| |
| 抄録 | A hereditary breast and ovarian cancer (HBOC) pedigree was detected via liquid biopsy, and cancer prevention was initiated for the patient’s daughter, after receiving a definitive result from BRCA genetic testing. A 48-yearold woman with ovarian cancer was administered precision medicine, which used cell-free DNA from plasma. The results revealed a pathogenic variant of BRCA1 as a presumed germline pathogenic mutation. We confirmed the germline pathological variant BRCA1 c.81-1G> A and suggested treatment with a PARP inhibitor. One of her three children had the variant, was diagnosed as an unaffected pathogenic variant carrier, and was advised to initiate surveillance. |
| キーワード | hereditary breast and ovarian cancer (HBOC) BRCA 1 presumed germline pathogenic variants (PGPV) germline findings cancer precision medicine |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 479 |
| 終了ページ | 483 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123164 |
| Web of Science KeyUT | 000882167300012 |
| JaLCDOI | 10.18926/AMO/63903 |
|---|---|
| フルテキストURL | 76_4_439.pdf |
| 著者 | Miyaji, Chikara| Takao, Soshi| Noguchi, Masayuki| Okazaki, Tsubasa| Sato, Shunsuke| Yorifuji, Takashi| |
| 抄録 | This study examined the relationship between cognitive/structural social capital and post-traumatic stress disorder (PTSD) among victims of heavy rain and flood. Participants were individuals aged≥18 years affected by the July 2018 heavy rainfall in the cities of Kurashiki and Soja, Japan, and living in temporary housing. We distributed five copies of a questionnaire to 1,991 households and received responses from 1,927 individuals (907 men, 1,008 women, 12 respondents of unspecified sex) in 1,029 households (51.7%). We estimated odds ratios (ORs) and 95% confidence intervals (CIs) for associations between high (vs. low) social capital and PTSD or other outcomes. After covariate adjustment, the odds of having PTSD were lower in participants with high cognitive social capital than those with low cognitive social capital (OR=0.346, 95%CI: 0.263-0.456). Elderly women with higher structural social capital tended to have lower PTSD odds than those with lower structural social capital (OR=0.671, 95%CI: 0.431-1.046). The opposite pattern was observed for elderly men (OR=1.315, 95%CI: 0.792-2.183). Cognitive social capital is a protective factor that may reduce PTSD or promote a favorable PTSD prognosis after heavy rainfall and flood events. The associations between structural social capital and PTSD differ by age and sex. |
| キーワード | social capital post-traumatic stress disorder disaster flooding |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 439 |
| 終了ページ | 446 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123159 |
| Web of Science KeyUT | 000882167300010 |
| JaLCDOI | 10.18926/AMO/63901 |
|---|---|
| フルテキストURL | 76_4_423.pdf |
| 著者 | Takahashi, Satoshi| Kushibe, Takuya| Akezaki, Yoshiteru| Horiike, Norio| |
| 抄録 | We compared the effects of an exercise intervention with that of exercise combined with nutrition therapy in patients with possible malnutrition and sarcopenia admitted to a recovery rehabilitation ward, and we examined the differences in the patients’ physical function and activities of daily living (ADLs). There were 16 patients in the Exercise group with exercise therapy and ADL exercises, and 14 patients in the Combined intervention group with exercise therapy, ADL exercises, and nutrition therapy. The survey items were body weight, body mass index, grip strength, lower-leg circumference, gait speed, and ADLs, each of which was measured at the baseline and at 2 weeks, 4 weeks, and at discharge. Significant improvements in grip strength were observed in the Combined intervention group as follows: at 4 weeks>at 2 weeks (p<0.05), and at discharge>baseline and 2 weeks (p<0.05). There were no significant changes in the Exercise group, and an interaction was recognized in both groups. Comprehensive rehabilitation including nutrition therapy is necessary for patients with possible malnutrition and/or sarcopenia, as our results indicate that nutrition therapy in addition to exercise therapy has the effect of promoting improvements of physical function in such patients. |
| キーワード | sarcopenia rehabilitation exercise therapy nutrition therapy grip strength |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 423 |
| 終了ページ | 428 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123157 |
| Web of Science KeyUT | 000882167300008 |
| JaLCDOI | 10.18926/AMO/63895 |
|---|---|
| フルテキストURL | 76_4_409.pdf |
| 著者 | Higashikawa, Toshihiro| Shigemoto, Kenji| Goshima, Kenichi| Iwai, Shintarou| Moriyama, Manabu| Usuda, Daisuke| Hangyou, Masahiro| Inujima, Hiromi| Nozaki, Kakeru| Yamaguchi, Miyako| Usuda, Kimiko| Nakahashi, Takeshi| Matsumoto, Tadami| Takashima, Shigeki| Kanda, Tsugiyasu| Horii, Takeshi| Okuro, Masashi| Sawaguchi, Takeshi| |
| 抄録 | We assessed risk factors for postoperative urinary retention (UR) in elderly males with femoral bone fractures: 169 Japanese males (mean age 81.95 ± 1.19 years) who had undergone hip surgery at a municipal hospital (Toyama, Japan). A multiple logistic regression analysis was used to test possible risk factors for UR: age, body mass index, serum albumin, cognitive impairment, activities of daily living (ADL), and history of diabetes mellitus (DM). UR occurred in 24 (14.2%) of the 169 patients. A multivariate logistic regression analysis with age adjustment showed that ADL (odds ratio [OR] 3.88; 95% confidence interval [CI]: 1.2-12.5, p=0.023) was significantly associated with the development of UR, and a history of DM showed marginal significance for UR occurrence (OR 0.36, 95%CI: 0.11-10, p=0.064). These results suggests that ADL is a risk factor for UR development in elderly males who have undergone surgery for femoral neck or trochanter fractures. |
| キーワード | elderly femoral bone fracture albumin urinary retention activities of daily living |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 409 |
| 終了ページ | 414 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123155 |
| Web of Science KeyUT | 000882167300006 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Akil, Caner| Tran, Linh T.| Orhant-Prioux, Magali| Baskaran, Yohendran| Senju, Yosuke| Takeda, Shuichi| Chotchuang, Phatcharin| Muengsaen, Duangkamon| Schulte, Albert| Manser, Edward| Blanchoin, Laurent| Robinson, Robert C.| |
| 発行日 | 2022-08-31 |
| 出版物タイトル | Communications Biology |
| 巻 | 5巻 |
| 号 | 1号 |
| 出版者 | Nature Portfolio |
| 開始ページ | 890 |
| ISSN | 2399-3642 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2022 |
| 論文のバージョン | publisher |
| PubMed ID | 36045281 |
| DOI | 10.1038/s42003-022-03783-1 |
| Web of Science KeyUT | 000849355300002 |
| 関連URL | isVersionOf https://doi.org/10.1038/s42003-022-03783-1 |
| JaLCDOI | 10.18926/AMO/63887 |
|---|---|
| フルテキストURL | 76_4_359.pdf |
| 著者 | Hiramatsu-Asano, Sumie| Wada, Jun| |
| 抄録 | Systemic lupus erythematosus (SLE) is a potentially fatal systemic autoimmune disease, and its etiology involves both genetic and environmental factors such as sex hormone imbalance, genetic predisposition, epigenetic regulation, and immunological factors. Dysregulation of microRNA (miRNA) is suggested to be one of the epigenetic factors in SLE. miRNA is a 22-nucleotide single-stranded noncoding RNA that contributes to post-transcriptional modulation of gene expression. miRNA targeting therapy has been suggested to be useful for the treatment of cancers and other diseases. Gene knockout and miRNA targeting therapy have been demonstrated to improve SLE disease activity in mice. However, these approaches have not yet reached the level of clinical application. miRNA targeting therapy is limited by the fact that each miRNA has multiple targets. In addition, the expression of certain miRNAs may differ among cell tissues within a single SLE patient. This limitation can be overcome by targeted delivery and chemical modifications. In the future, further research into miRNA chemical modifications and delivery systems will help us develop novel therapeutic agents for SLE. |
| キーワード | systemic lupus erythematosus miRNA miRNA targeting therapy |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2022-08 |
| 巻 | 76巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 359 |
| 終了ページ | 371 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2022 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 36123150 |
| Web of Science KeyUT | 000882167300002 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Tanimoto, Terutaka| Noda, Takuo| Imaji, Reisuke| Nouso, Hiroshi| |
| キーワード | Esophageal atresia Communicating bronchopulmonary foregut malformation Broncho-esophageal fistula |
| 発行日 | 2022-08-15 |
| 出版物タイトル | Surgical Case Reports |
| 巻 | 8巻 |
| 号 | 1号 |
| 出版者 | Springer |
| 開始ページ | 156 |
| ISSN | 2198-7793 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2022. |
| 論文のバージョン | publisher |
| PubMed ID | 35969287 |
| DOI | 10.1186/s40792-022-01513-7 |
| Web of Science KeyUT | 000840835900001 |
| 関連URL | isVersionOf https://doi.org/10.1186/s40792-022-01513-7 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Kubota, Satoshi| Aoyama, Eriko| Takigawa, Masaharu| Nishida, Takashi| |
| キーワード | fibroblast growth factor cellular communication network factor cartilage skeletal development CCN2 |
| 発行日 | 2022-08-02 |
| 出版物タイトル | International Journal Of Molecular Sciences |
| 巻 | 23巻 |
| 号 | 15号 |
| 出版者 | MDPI |
| 開始ページ | 8592 |
| ISSN | 1422-0067 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 35955724 |
| DOI | 10.3390/ijms23158592 |
| Web of Science KeyUT | 000839283400001 |
| 関連URL | isVersionOf https://doi.org/10.3390/ijms23158592 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Pramukantoro, Eko Sakti| Gofuku, Akio| |
| キーワード | heartbeats machine learning deep learning wearable sensor |
| 発行日 | 2022-07 |
| 出版物タイトル | Sensors |
| 巻 | 22巻 |
| 号 | 14号 |
| 出版者 | MDPI |
| 開始ページ | 5080 |
| ISSN | 1424-8220 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2022 by the authors. |
| 論文のバージョン | publisher |
| PubMed ID | 35890769 |
| DOI | 10.3390/s22145080 |
| Web of Science KeyUT | 000831466200001 |
| 関連URL | isVersionOf https://doi.org/10.3390/s22145080 |