検索条件

閉じる

検索結果 728 件

フルテキストURL fulltext20220714-1.pdf figure20220714-1.pdf
著者 Yokoo, Suguru| Saiga, Kenta| Demiya, Koji| Ohashi, Hideki| Horita, Masahiro| Ozaki, Toshifumi|
キーワード Arthroscopic ankle arthrodesis Coronal ratio Delayed union Inter-screw distance Non-union Sagittal ratio Tibial width
備考 This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00590-022-03307-x|
発行日 2022-06-22
出版物タイトル European Journal of Orthopaedic Surgery & Traumatology
33巻
5号
出版者 Springer Science and Business Media LLC
開始ページ 1557
終了ページ 1563
ISSN 1432-1068
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s), under exclusive licence to Springer-Verlag France SAS, part of Springer Nature 2022
論文のバージョン author
PubMed ID 35732958
DOI 10.1007/s00590-022-03307-x
Web of Science KeyUT 000814487200001
関連URL isVersionOf https://doi.org/10.1007/s00590-022-03307-x
フルテキストURL fulltext20220708-4.pdf nep-supinfo.pdf
著者 Tsuji, Kenji| Kitamura, Shinji| Uchida, Haruhito A.| Wada, Jun|
キーワード Renal biopsy clinical nephrology ultrasound
備考 This is the peer reviewed version of the following article: [Tsuji, K, Kitamura, S, Uchida, HA, Wada, J. Simulation for ultrasound-guided renal biopsy using boiled egg. Nephrology. 2022; 27( 9): 753- 757. doi:10.1111/nep.14079], which has been published in final form at [https://doi.org/10.1111/nep.14079]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
This fulltext is available in June 2023.|
発行日 2022-06-28
出版物タイトル Nephrology
27巻
9号
出版者 Wiley
開始ページ 753
終了ページ 757
ISSN 1320-5358
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 Asian Pacific Society of Nephrology.
論文のバージョン author
PubMed ID 35762140
DOI 10.1111/nep.14079
Web of Science KeyUT 000816988200001
関連URL isVersionOf https://doi.org/10.1111/nep.14079
JaLCDOI 10.18926/AMO/63740
フルテキストURL 76_3_307.pdf
著者 Sugiura, Satoshi| Kitamura, Yoshihisa| Izushi, Yasuhisa| Ushio, Soichiro| Sendo, Toshiaki|
抄録 In recent years, medical staff including physicians and nurses have been participating in home health care, reflecting the needs of an aging society in Japan. Pharmacists are also asked to work on home health care teams to ensure the medical safety of patients. It currently remains unclear whether direct communication, i.e. a meeting, between home-visiting physicians and pharmacists contributes to the proper use of medications and continuous medical care. We retrospectively analyzed the medication management guidance records of home-visited patients who received their first home visit between April 2014 and March 2017. We collected data on pharmacist inquiries, the duration of visits, and details from a meeting between home-visiting physicians and pharmacists. Thirty-five patients were included. At the first visit, the inquiry rate by pharmacists was 65.7%. The prescription question rate was significantly lower in patients with a meeting than in those without (p=0.033). The average duration of visits was significantly shorter for home-visited patients whose health care providers had a meeting (p=0.007). These results suggest that pharmacists who held a meeting with the home-visiting physician before the first patient visit were able to resolve drug-related issues earlier, which increased the work efficiency of home-visiting pharmacists.
キーワード home visit pharmacist meeting inquiry home health care
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-06
76巻
3号
出版者 Okayama University Medical School
開始ページ 307
終了ページ 315
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 35790361
Web of Science KeyUT 000823568300001
JaLCDOI 10.18926/AMO/63738
フルテキストURL 76_3_291.pdf
著者 Miyake, Yoshiaki| Mitani, Shigeru| Namba, Yoshifumi| Umehara, Norifumi| Kawamoto, Toyohiro| Furuichi, Shuro|
抄録 Total hip arthroplasty (THA) provides relief from hip pain and improves hip function. However, periprosthetic joint infection (PJI) remains an area of concern. We examined the detection rate of bacteria from surgical fields in wound closure, along with the relationship between bacterial detection rate and type of antiseptic, surgery time, and surgeon experience for 500 patients who underwent THA at our department. The mean age at surgery was 64.3 (± 27.3) years. The bacterial detection rate was 4.6%. None of the cases revealed PJI. No significant association between the detection rate and type of antiseptic used or surgery time was observed. However, for patients treated by surgeons with < 10 years of orthopedic experience, a detection rate of 7.3% was found, while a rate of 1.3% was observed for those treated by surgeons with ≥ 10 years of orthopedic experience. This finding indicated that orthopedic experience of less than 10 years was significantly associated with an increased bacterial detection rate (chi-square test, p=0.002). The detection rate was associated with surgeon experience but not with antiseptic type or surgery time. It is possible that intraoperative handling may increase the number of bacteria in surgical fields in wound closure.
キーワード total hip arthroplasty bacterial contamination periprosthetic joint infection
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-06
76巻
3号
出版者 Okayama University Medical School
開始ページ 291
終了ページ 295
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 35790359
Web of Science KeyUT 000823568300008
フルテキストURL fulltext20220630-3.pdf
著者 Maki, Yuta| Kawata, Kazuki| Liu, Yanbo| Goo, Kang‐Ying| Okamoto, Ryo| Kajihara, Yasuhiro| Satoh, Ayano|
キーワード glycoprotein N-glycan cholera toxin native chemical ligation live imaging
備考 This is the peer reviewed version of the following article: [Y. Maki, K. Kawata, Y. Liu, K.-Y. Goo, R. Okamoto, Y. Kajihara, A. Satoh, Chem. Eur. J. 2022, 28, e202201253], which has been published in final form at [https://doi.org/10.1002/chem.202201253]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
This fulltext is available in May 2023.|
発行日 2022-05-23
出版物タイトル Chemistry - A European Journal
28巻
37号
出版者 Wiley
開始ページ e202201253
ISSN 0947-6539
NCID AA11076269
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 Wiley-VCH GmbH
論文のバージョン author
PubMed ID 35604098
DOI 10.1002/chem.202201253
Web of Science KeyUT 000798823300001
関連URL isVersionOf https://doi.org/10.1002/chem.202201253
フルテキストURL K0006567_abstract_review.pdf K0006567_fulltext.pdf
著者 中川 裕貴|
発行日 2022-03-25
資料タイプ 学位論文
学位授与番号 甲第6567号
学位授与年月日 2022-03-25
学位・専攻分野 博士(医学)
授与大学 岡山大学
言語 英語
著作権者 © 2021 Japanese Dermatological Association
フルテキストURL K0006542_abstract_review.pdf K0006542_fulltext.pdf K0006542_summary.pdf
著者 吉永 香澄|
発行日 2022-03-25
資料タイプ 学位論文
学位授与番号 甲第6542号
学位授与年月日 2022-03-25
学位・専攻分野 博士(医学)
授与大学 岡山大学
言語 英語
著作権者 © 2020 The Japanese Urological Association
フルテキストURL K0006530_abstract_review.pdf K0006530_fulltext.pdf K0006530_summary.pdf
著者 久保 光太郎|
発行日 2022-03-25
資料タイプ 学位論文
学位授与番号 甲第6530号
学位授与年月日 2022-03-25
学位・専攻分野 博士(医学)
授与大学 岡山大学
言語 英語
著作権者 © 2021 Japan Society of Obstetrics and Gynecology.
フルテキストURL fulltext.pdf
著者 Amioka, Naofumi| Takaya, Yoichi| Nakamura, Kazufumi| Kondo, Megumi| Akazawa, Kaoru| Ohno, Yuko| Ichikawa, Keishi| Nakayama, Rie| Saito, Yukihiro| Akagi, Satoshi| Miyoshi, Toru| Yoshida, Masashi| Morita, Hiroshi| Ito, Hiroshi|
発行日 2022-05-24
出版物タイトル Scientific Reports
12巻
1号
出版者 Nature Portfolio
開始ページ 8776
ISSN 2045-2322
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2022
論文のバージョン publisher
PubMed ID 35610503
DOI 10.1038/s41598-022-12935-6
Web of Science KeyUT 000799975800070
関連URL isVersionOf https://doi.org/10.1038/s41598-022-12935-6
フルテキストURL fulltext20220602-2.pdf
著者 Abe, Takumi| Yamashiro, Toshiki| Shimizu, Kaho| Sawada, Daisuke|
キーワード hemiaminals HFIP indoles molecule editing ring-switch
備考 This is the peer reviewed version of the following article: [T. Abe, T. Yamashiro, K. Shimizu, D. Sawada, Chem. Eur. J. 2022, 28, e202201113.], which has been published in final form at [https://doi.org/10.1002/chem.202201113]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext will be available in May 2023.|
発行日 2022-05-19
出版物タイトル Chemistry – A European Journal
28巻
37号
出版者 Wiley
開始ページ e202201113
ISSN 0947-6539
NCID AA11076269
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 Wiley-VCH GmbH
論文のバージョン author
PubMed ID 35438809
DOI 10.1002/chem.202201113
Web of Science KeyUT 000797645300001
関連URL isVersionOf https://doi.org/10.1002/chem.202201113
フルテキストURL fulltext20220511-2.pdf
著者 Okada, Kazuaki| Sato, Akira| Hiramoto, Akiko| Isogawa, Rena| Kurosaki, Yuji| Higaki, Kazutaka| Miyoshi, Shin-Ichi| Chang, Kyung-Soo| Kim, Hye-Sook|
発行日 2019-7-5
出版物タイトル Tropical Medicine and Health
47巻
1号
出版者 Springer Science and Business Media LLC
開始ページ 40
ISSN 1349-4147
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s).
論文のバージョン publisher
PubMed ID 31312098
DOI 10.1186/s41182-019-0167-4
Web of Science KeyUT 000475630800001
関連URL isVersionOf https://doi.org/10.1186/s41182-019-0167-4
フルテキストURL fulltext20220428-4.pdf
著者 Miyatake, Takahisa| S. Abe, Masato| Matsumura, Kentarou| Yoshii, Taishi|
キーワード biological clock coleoptera death feigning thanatosis tonic immobility
備考 This is the peer reviewed version of the following article: [Miyatake, T., Abe, M. S., Matsumura, K., & Yoshii, T. (2022). Artificial selections for death-feigning behavior in beetles show correlated responses in amplitude of circadian rhythms, but the period of the rhythm does not. Ethology, 128, 453– 460. https://doi.org/10.1111/eth.13279], which has been published in final form at [https://doi.org/10.1111/eth.13279]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.|
発行日 2022-03-29
出版物タイトル Ethology
128巻
出版者 Wiley
開始ページ 453
終了ページ 460
ISSN 0179-1613
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 Wiley-VCH GmbH
論文のバージョン author
DOI 10.1111/eth.13279
Web of Science KeyUT 000774207200001
関連URL isVersionOf https://doi.org/10.1111/eth.13279
フルテキストURL fulltext20220428-1.pdf
著者 Wang, Qiong| Li, Yuying| Kosami, Ken‐ichi| Liu, Chaochao| Li, Jing| Zhang, Dan| Miki, Daisuke| Kawano, Yoji|
キーワード NLR protein plasma membrane localization self-association effector triggered immunity rice
備考 This is the peer reviewed version of the following article: [Wang, Q., Li, Y., Kosami, K.-i., Liu, C., Li, J., Zhang, D. et al. (2022) Three highly conserved hydrophobic residues in the predicted α2-helix of rice NLR protein Pit contribute to its localization and immune induction. Plant, Cell & Environment, 1– 15. https://doi.org/10.1111/pce.14315], which has been published in final form at https://doi.org/10.1111/pce.14315. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.|
発行日 2022-4-7
出版物タイトル Plant, Cell &amp
45巻
出版者 Wiley
開始ページ 1876
終了ページ 1890
ISSN 0140-7791
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 John Wiley & Sons Ltd.
論文のバージョン author
PubMed ID 35312080
DOI 10.1111/pce.14315
Web of Science KeyUT 000779738600001
関連URL isVersionOf https://doi.org/10.1111/pce.14315
JaLCDOI 10.18926/AMO/63411
フルテキストURL 76_2_173.pdf
著者 Miyake, Yoshiaki| Mitani, Shigeru| Namba, Yoshifumi| Umehara, Norifumi| Kawamoto, Toyohiro| Furuichi, Shuro|
抄録 To the best of our knowledge, no previous studies have reported a relationship between osteoarthritis (OA) of the lower limbs and OA of the shoulder joints. We evaluated the correlation between shoulder OA and hip OA. We collected contrast-enhanced computed tomography (CECT) images of the shoulder joints of 159 patients with hip OA who underwent primary total hip arthroplasty (THA). The images, taken 1 week after THA to monitor venous thromboembolism (VTE), were used to examine the prevalence of shoulder OA. They were compared with those of 103 controls who underwent CECT during the same period to monitor VTE. Shoulder OA was observed in 15% of the controls and 24% of the THA patients. Although the rate was somewhat higher in the THA group, the difference was not significant. However, in the THA group, significantly more patients with bilateral hip OA (33%) had shoulder OA than those with unilateral hip OA (17%). In summary, the prevalence of shoulder OA was significantly higher in patients with bilateral hip OA. In these patients, pain and instability in the hip joints require them to use arm support to stand up or walk, putting the weight-bearing shoulder at risk of developing OA.
キーワード shoulder osteoarthritis hip osteoarthritis weight-bearing shoulder total hip arthroplasty
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-04
76巻
2号
出版者 Okayama University Medical School
開始ページ 173
終了ページ 177
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 35503445
Web of Science KeyUT 000792374900009
JaLCDOI 10.18926/AMO/63406
フルテキストURL 76_2_129.pdf
著者 Kubo, Kotaro| Nakamura, Keiichiro| Okamoto, Kazuhiro| Matsuoka, Hirofumi| Ida, Naoyuki| Haruma, Tomoko| Ogawa, Chikako| Masuyama, Hisashi|
抄録 Cancer patients have increased risk of venous thromboembolism (VTE) that must be assessed before treatment. This study aimed to determine effective VTE biomarkers in gynecologic cancer (GC). We investigated the correlation between D-dimer levels, Khorana risk score (KRS), Glasgow prognostic score (GPS), and VTE in 1499 GC patients (583 cervical cancer (CC), 621 endometrial cancer (EC), and 295 ovarian cancer (OC) patients) treated at our institution between January 2008 and December 2019. χ2 and Mann–Whitney U-tests were used to determine statistical significance. We used receiver operating characteristic-curve analysis to evaluate the discriminatory ability of each parameter. D-dimer levels were significantly correlated with KRS and GPS in patients with GC. VTE was diagnosed in 11 CC (1.9%), 27 EC (4.3%), and 39 OC patients (13.2%). Optimal D-dimer cut-off values for VTE were 3.1, 3.2, and 3.9 μg/ml in CC, EC and OC patients, respectively. D-dimer could significantly predict VTE in all GC patients. Furthermore, D-dimer combined with GPS was more accurate in predicting VTE than other VTE biomarkers in stage IIIC and IVA OC (AUC: 0.846; p<0.001). This study demonstrates that combined D-dimer and GPS are useful in predicting VTE in patients with OC.
キーワード D-dimer gynecologic cancer venous thromboembolism
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-04
76巻
2号
出版者 Okayama University Medical School
開始ページ 129
終了ページ 135
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 35503440
Web of Science KeyUT 000792374900004
フルテキストURL fulltext.pdf
著者 Xue, Ruizhi| Lin, Wenfeng| Fujita, Hirofumi| Sun, Jingkai| Kinoshita, Rie| Ochiai, Kazuhiko| Futami, Junichiro| Watanabe, Masami| Ohuchi, Hideyo| Sakaguchi, Masakiyo| Tang, Zhengyan| Huang, Peng| Nasu, Yasutomo| Kumon, Hiromi|
キーワード Dkk3/REIC fibrous sheath knock-out RNA-seq spermiation sperm motility
発行日 2022-01-31
出版物タイトル Genes
13巻
2号
出版者 MDPI
開始ページ 285
ISSN 2073-4425
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2022 by the authors.
論文のバージョン publisher
PubMed ID 35205329
DOI 10.3390/genes13020285
Web of Science KeyUT 000762788200001
関連URL isVersionOf https://doi.org/10.3390/genes13020285
タイトル(別表記) Downregulation of PAR-1 and PAR-2 by Rivaroxaban
フルテキストURL fulltext20220309-4.pdf Figure20220309-4.pdf
著者 Morihara, Ryuta| Yamashita, Toru| Kono, Syoichiro| Shang, Jingwei| Nakano, Yumiko| Sato, Kota| Hishikawa, Nozomi| Ohta, Yasuyuki| Heitmeier, Stefan| Perzborn, Elisabeth| Abe, Koji|
キーワード PAR-3 PAR-4 tissue plasminogen activator warfarin
備考 This is the peer reviewed version of the following article: [Morihara, R., Yamashita, T., Kono, S., Shang, J., Nakano, Y., Sato, K., Hishikawa, N., Ohta, Y., Heitmeier, S., Perzborn, E. and Abe, K. (2017), Reduction of intracerebral hemorrhage by rivaroxaban after tPA thrombolysis is associated with downregulation of PAR-1 and PAR-2. Journal of Neuroscience Research, 95: 1818-1828. https://doi.org/10.1002/jnr.24013], which has been published in final form at [https://doi.org/10.1002/jnr.24013]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.|
発行日 2016-12-30
出版物タイトル Journal of Neuroscience Research
95巻
9号
出版者 Wiley
開始ページ 1818
終了ページ 1828
ISSN 0360-4012
NCID AA00703378
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 ©2016 Wiley Periodicals, Inc.
論文のバージョン author
DOI 10.1002/jnr.24013
Web of Science KeyUT 000427450300275
関連URL isVersionOf https://doi.org/10.1002/jnr.24013
JaLCDOI 10.18926/AMO/63212
フルテキストURL 76_1_57.pdf
著者 Iguchi, Toshihiro| Hiraki, Takao| Matsui, Yusuke| Toji, Tomohiro| Uka, Mayu| Tomita, Koji| Komaki, Toshiyuki| Umakoshi, Noriyuki| Mitsuhashi, Toshiharu| Kanazawa, Susumu|
抄録 To evaluate the volume and heat-sink effects of microwave ablation (MWA) in the ablation zone of the normal swine lung. MWA at 100 W was performed for 1, 2, and 3 min in 7, 5, and 5 lung zones, respectively. We assessed the histopathology in the ablation zones and other outcome measures: namely, length of the longest long and short axes, sphericity, ellipsoid area, and ellipsoid volume. The mean long- and short-axis diameters were 22.0 and 14.1 mm in the 1-min ablation zone, 27.6 and 20.2 mm in the 2-min ablation zone; and 29.2 and 21.2 mm in the 3-min ablation zone, respectively. All measures, except sphericity, were significantly less with 1-min ablation than with either 2- or 3-min ablation. There were no significant differences between the 2- and 3-min ablation zones, but all measures except sphericity were larger with 3-min ablation. Although there were no blood vessels that resulted in a heat-sink effect within the ablation zones, the presence of bronchi nearby in 5 lung ablation zones resulted in reduced ablation size. In high-power, short-duration MWA, the lung ablation volume was affected by ablation time. Some ablations showed that a heat-sink effect by a neighboring bronchus might occur.
キーワード microwave ablation lung ablation zone heat-sink effect swine
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-02
76巻
1号
出版者 Okayama University Medical School
開始ページ 57
終了ページ 62
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 35236999
Web of Science KeyUT 000762812700008
JaLCDOI 10.18926/AMO/63209
フルテキストURL 76_1_51.pdf
著者 Eto, Eriko| Tani, Kazumasa| Maki, Jota| Hayata, Kei| Masuyama, Hisashi|
抄録 Polycystic ovary syndrome (PCOS) is a common endocrine metabolic disorder that is associated with high insulin resistance and obesity. However, ~70% of women with PCOS in Japan are non-obese. We retrospectively analyzed the cases of 163 Japanese women with PCOS who visited our Ob/Gyn department in 2006-2018 to determine which has a greater effect on insulin resistance: PCOS or obesity. We reviewed the women’s medical records and calculated their insulin resistance and insulin secretion. The women’s mean age and pre-pregnancy body mass index (BMI) were 30±5.8 years and 24.8±5.6 kg/m2, respectively; their mean ± SD fasting plasma glucose, 94.1±13.7 mg/dL; HOMA-IR, 2.1±2.0; QUICKI, 0.4±0.0; and HOMA-β, 108.9±88.0%. Sixtyeight women were pregnant, and 37% (n=25) were obese (BMI ≥ 25 kg/m2). Obesity had a greater effect on insulin resistance: fasting plasma glucose F(1, 53)=6.134, p<0.05; fasting insulin F(1, 53)=31.606, p<0.01; HOMA-IR F(1, 53)=31.670, p<0.01; QUICKI F(1, 53)=16.156, p<0.01. There was no significant difference in values other than QUICKI and testosterone between the women with and without PCOS. Obesity thus had a greater effect on increased insulin resistance in pregnant women with PCOS. Further studies of the insulin resistance of non-obese women with PCOS is needed, as non-obese women with PCOS are common in Asia.
キーワード polycystic ovary syndrome insulin resistance obesity pregnancy
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-02
76巻
1号
出版者 Okayama University Medical School
開始ページ 51
終了ページ 56
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 35236998
Web of Science KeyUT 000762812700007
JaLCDOI 10.18926/AMO/63203
フルテキストURL 76_1_7.pdf
著者 Takami, Masao| Yamamoto, Koichiro| Hanayama, Yoshihisa| Nakano, Yasuhiro| Hasegawa, Kou| Obika, Mikako| Hagiya, Hideharu| Furukawa, Masanori| Otsuka, Fumio|
抄録 Subclinical hypothyroidism (SCH) is diagnosed when serum thyrotropin (TSH) is elevated despite a normal thyroxine level and is known to increase the risk of metabolic disorders. This study was conducted to identify potential laboratory markers suspicious for latent SCH. We retrospectively reviewed 958 outpatients in whom thyroid functions had been examined. Eighty-five (9.1%) of the 939 analyzed subjects had SCH (73% females). In the SCH group, median serum TSH and FT4 levels were 5.04 μU/ml and 1.19 ng/dl, respectively, and auto-thyroid antibodies were detected in 53.8% of patients. SCH group patients were significantly older than patients in the euthyroid group, while there was no intergroup difference in BMI. However, 56.5% of the SCH patients were asymptomatic. In the SCH group, serum aspartate aminotransferase and low-density lipoprotein cholesterol (LDL-C) levels were significantly higher, and the estimated glomerular filtration rate (eGFR) was significantly lower than in the euthyroid group. Among patients less than 65 years of age, SCH patients tended to have lower eGFR and higher LDL-C than euthyroid patients. Age-dependent reductions of red blood cells and serum albumin were more prominent in the SCH than the euthyroid group. Biochemical changes with aging are useful as potential clues for suspecting latent SCH.
キーワード aging renal function cholesterol subclinical hypothyroidism thyroid function
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2022-02
76巻
1号
出版者 Okayama University Medical School
開始ページ 7
終了ページ 15
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 35236993
Web of Science KeyUT 000762812700002