検索結果 - 岡山大学学術成果リポジトリ

Retroperitoneal leiomyosarcoma in a female patient with a germline splicing variant RAD51D c.904-2A > T: a case report

フルテキストURL	fulltext.pdf
著者	Futagawa, Mashu\| Yamamoto, Hideki\| Kochi, Mariko\| Urakawa, Yusaku\| Sogawa, Reimi\| Kato, Fumino\| Okazawa-Sakai, Mika\| Ennishi, Daisuke\| Shinozaki, Katsunori\| Inoue, Hirofumi\| Yanai, Hiroyuki\| Hirasawa, Akira\|
キーワード	RAD51D Splice variant Leiomyosarcoma Homologous recombination (HR) Cancer susceptibility Presumed germline pathogenic variant (PGPV)
発行日	2021-11-27
出版物タイトル	Hereditary Cancer In Clinical Practice
巻	19巻
号	1号
出版者	BMC
開始ページ	48
ISSN	1731-2302
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s).
論文のバージョン	publisher
PubMed ID	34838098
DOI	10.1186/s13053-021-00205-x
Web of Science KeyUT	000722986000001
関連URL	isVersionOf https://doi.org/10.1186/s13053-021-00205-x

Histopathological and Immunohistochemical Studies on The Breast Cancer Stem Cells Developed in The Microenvironment of Mouse Mammary Fat Pads

フルテキストURL	K0006522_abstract_review.pdf K0006522_fulltext.pdf
著者	HAGAR ALI ABDUL RAHEEM ABU QUORA \|
発行日	2021-09-24
資料タイプ	学位論文
学位授与番号	甲第6522号
学位授与年月日	2021-09-24
学位・専攻分野	博士（統合科学）
授与大学	岡山大学
言語	英語

RUNX2 Phosphorylation by Tyrosine Kinase ABL Promotes Breast Cancer Invasion

フルテキストURL	K0006473_abstract_review.pdf K0006473_fulltext.pdf
著者	賀芳\|
発行日	2021-09-24
資料タイプ	学位論文
学位授与番号	甲第6473号
学位授与年月日	2021-09-24
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語
著作権者	© 2021 He, Matsumoto, Asano, Yamamura, Katsuyama, La Rose, Tomonobu, Komalasari, Sakaguchi, Rottapel and Wada.

Effect of isoflavones on breast cancer cell development and their impact on breast cancer treatments

フルテキストURL	K0006437_abstract_review.pdf K0006437_fulltext.pdf
著者	鳩野みなみ\|
発行日	2021-09-24
資料タイプ	学位論文
学位授与番号	甲第6437号
学位授与年月日	2021-09-24
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語
著作権者	© Springer Science+Business Media, LLC, part of Springer Nature 2020

Chronic exposure to FGF2 converts iPSCs into cancer stem cells with an enhanced integrin/focal adhesion/PI3K/AKT axis

フルテキストURL	fulltext20211026-1.pdf Supplementary Figures.docx Supplementary Table S1.docx Supplementary Table S2.xlsx Supplementary Table S3.docx Supplementary Table S4.docx Supplementary Table S5.xls Supplementary Table S6.docx
著者	Sheta, Mona\| Hassan, Ghmkin\| Afify, Said M.\| Monzur, Sadia\| Kumon, Kazuki\| Abu Quora, Hagar A.\| Farahat, Mahmoud\| Zahra, Maram H.\| Fu, Xiaoying\| Seno, Akimasa\| Seno, Masaharu\|
キーワード	Cancer initiation Cancer stem cells iPSCs FGF2 Chronic inflammation
備考	©2021 Elsevier BV. This manuscript version is made available under the CC-BY-NC-ND 4.0 License.http://creativecommons.org/licenses/by-nc-nd/4.0/.This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.canlet.2021.08.026] .\|
発行日	2021-11
出版物タイトル	Cancer Letters
巻	521巻
号	28号
出版者	Elsevier BV
開始ページ	142
終了ページ	154
ISSN	0304-3835
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 Elsevier B.V.
論文のバージョン	author
PubMed ID	34455015
DOI	10.1016/j.canlet.2021.08.026
Web of Science KeyUT	000704341600001
関連URL	isVersionOf https://doi.org/10.1016/j.canlet.2021.08.026

Added Diagnostic Value of Cerebrospinal Fluid Carcinoembryonic Antigen in a Patient with Leptomeningeal Carcinomatosis as the Initial Manifestation of Gastric Cancer

JaLCDOI	10.18926/AMO/62781
フルテキストURL	75_5_659.pdf
著者	Ino, Riku\| Sada, Ken-ei \| Miyauchi, Atsushi\| Hashimoto, Daisuke\| Nojima, Shigeru\| Yamanaka, Shingo\| Kawamura, Masafumi\|
抄録	A 77-year-old woman with no history of malignancy presented with anorexia and bilateral lower extremity weakness. Her consciousness level worsened daily, so we performed a lumbar puncture. Cerebrospinal fluid (CSF) analysis indicated meningitis, but three rounds of CSF cytology showed no malignant cells. The patient’s carcinoembryonic antigen (CEA) level was highly elevated in CSF, but normal in serum. Through gadolinium-enhanced brain/spinal magnetic resonance imaging and gastrointestinal endoscopy, she was diagnosed with leptomeningeal carcinomatosis (LC) from gastric cancer. CEA level in CSF facilitated the diagnosis of LC from gastric cancer because there were no malignant cells on CSF cytology.
キーワード	leptomeningeal carcinomatosis gastric cancer carcinoembryonic antigen cerebrospinal fluid cytology
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2021-10
巻	75巻
号	5号
出版者	Okayama University Medical School
開始ページ	659
終了ページ	661
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34703051
Web of Science KeyUT	000711568400006
NAID	120007166666

Gefitinib induction followed by chemoradiotherapy in EGFR-mutant, locally advanced non-small-cell lung cancer: LOGIK0902/OLCSG0905 phase II study

フルテキストURL	fulltext.pdf
著者	Hotta, K.\| Saeki, S.\| Yamaguchi, M.\| Harada, D.\| Bessho, A.\| Tanaka, K.\| Inoue, K.\| Gemba, K.\| Shiojiri, M.\| Kato, Y.\| Ninomiya, T.\| Kubo, T.\| Kishimoto, J.\| Shioyama, Y.\| Katsui, K.\| Sasaki, J.\| Kiura, K.\| Sugio, K.\|
キーワード	non-small-cell lung cancer locally advanced setting chemoradiation epidermal growth factor receptor
発行日	2021-08
出版物タイトル	ESMO Open
巻	6巻
号	4号
出版者	Elsevier
開始ページ	100191
ISSN	2059-7029
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 The Author(s).
論文のバージョン	publisher
PubMed ID	34153652
DOI	10.1016/j.esmoop.2021.100191
Web of Science KeyUT	000703610200037
関連URL	isVersionOf https://doi.org/10.1016/j.esmoop.2021.100191

Hereditary pancreatic cancer

フルテキストURL	fulltext20211014-1.pdf
著者	Abe, Kodai\| Kitago, Minoru\| Kitagawa, Yuko\| Hirasawa, Akira\|
キーワード	Cancer predisposition gene Familial pancreatic cancer Hereditary pancreatic cancer Multigene panel testing Surveillance
発行日	2021-9-2
出版物タイトル	International Journal of Clinical Oncology
巻	26巻
号	10号
出版者	Springer Science and Business Media LLC
開始ページ	1784
終了ページ	1792
ISSN	1341-9625
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2021
論文のバージョン	publisher
PubMed ID	34476650
DOI	10.1007/s10147-021-02015-6
Web of Science KeyUT	000692076600001
関連URL	isVersionOf https://doi.org/10.1007/s10147-021-02015-6

Bendamustine Plus Rituximab as Salvage Treatment for Patients with Relapsed or Refractory Low-grade B-cell Lymphoma and Mantle Cell Lymphoma: A Single-Center Retrospective Study

JaLCDOI	10.18926/AMO/62398
フルテキストURL	75_4_461.pdf
著者	Murakami, Hiroyuki\| Yoshioka, Takanori\| Moriyama, Takashi\| Ishikawa, Tatsunori\| Makita, Masanori\| Sunami, Kazutaka\|
抄録	Bendamustine plus rituximab (B-R) is an effective therapy for relapsed or refractory (r/r) low-grade B-cell lymphoma (LGBCL) and mantle cell lymphoma (MCL); however, clinical data from Japanese patients treated with B-R therapy are limited. We retrospectively evaluated the efficacy and safety of B-R therapy in 42 patients who received B-R therapy at our hospital for r/r LGBCL and MCL. All patients received intravenous (IV) ritux-imab 375 mg/m2 on day 1 and IV bendamustine 90 mg/m2 on days 2 and 3 every 28 days for up to 6 cycles. The common histologic subtypes were follicular lymphoma (n = 29, 70%), marginal zone lymphoma (n = 6, 14%), and MCL (n = 5, 12%). The overall response rate was 93%, with 62% complete response and complete response unconfirmed. The median progression-free survival (PFS) was 38 months (95% confidence interval [CI], 24.6 to not reached [NR]), and the median overall survival (OS) was 80 months (95% CI, 60.7 to NR). Patients receiving a cumulative dose of bendamustine ≥ 720 mg/m2 showed a significantly longer PFS and OS. Grade 3/4 adverse events (≥ 10%) included neutropenia (55%), lymphopenia (69%), and nausea (24%). B-R therapy was effective and well tolerated, and the cumulative dose of bendamustine was associated with a favorable outcome.
キーワード	bendamustine low grade B-cell lymphoma mantle cell lymphoma
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-08
巻	75巻
号	4号
出版者	Okayama University Medical School
開始ページ	461
終了ページ	469
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34511613
Web of Science KeyUT	000697944600008
NAID	120007146041

Differences in Attitudes and Practices of Cancer Pain Management between Medical Oncologists and Palliative Care Physicians

JaLCDOI	10.18926/AMO/62394
フルテキストURL	75_4_431.pdf
著者	Kunitomi, Toshiki\| Nasu, Junichirou\| Minami, Daisuke\| Iwamoto, Takayuki\| Nishie, Hiroyuki\| Saito, Shinya\| Fujiwara, Toshiyoshi\| Matsuoka, Junji\|
抄録	This study aimed to evaluate whether there are differences in the attitudes and practices of cancer pain manage-ment between medical oncologists and palliative care physicians. An online nationwide survey was used to collect responses from board-certified medical oncologists and palliative care physicians in Japan. The survey questionnaire comprised 30 questions. The differences in responses between medical oncologists and palliative care physicians were examined. Out of the 1,227 questionnaires sent, 522 (42.5%) were returned. After apply-ing the exclusion criteria, 445 questionnaires (medical oncologists: n = 283; palliative care physicians: n = 162) were retained for analysis. Among the questions about potential barriers to optimal cancer pain man-agement, both medical oncologists and palliative care physicians considered the reluctance of patients to take opioids due to fear of adverse effects as the greatest barrier. Significantly different ratings between medical oncologists and palliative care physicians were observed on 5 of the 8 questions in this area. Significantly differ-ent ratings were observed for all questions concerning pain specialists and their knowledge. For effective cancer pain management, it is important to account for differences in attitudes and practice between medical oncolo-gists and palliative care physicians.
キーワード	cancer pain management opioid medical oncologist palliative care physician barriers
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-08
巻	75巻
号	4号
出版者	Okayama University Medical School
開始ページ	431
終了ページ	437
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34511609
Web of Science KeyUT	000697944600004
NAID	120007146037

Factors Affecting Participation in Leisure Activities in Patients after Breast Cancer Surgery

フルテキストURL	fulltext.pdf
著者	Akezaki, Yoshiteru\| Nakata, Eiji\| Kikuuchi, Masato\| Tominaga, Ritsuko\| Kurokawa, Hideaki\| Okamoto, Masaki\| Hamada, Makiko\| Aogi, Kenjiro\| Ohsumi, Shozo\| Sugihara, Shinsuke\|
キーワード	breast cancer leisure surgery rehabilitation factor
発行日	2021-08-22
出版物タイトル	Healthcare
巻	9巻
号	8号
出版者	MDPI
開始ページ	1078
ISSN	2227-9032
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 by the authors.
論文のバージョン	publisher
PubMed ID	34442215
DOI	10.3390/healthcare9081078
Web of Science KeyUT	000690566600001
関連URL	isVersionOf https://doi.org/10.3390/healthcare9081078

New field‑in‑field with two reference points method for whole breast radiotherapy: Dosimetric analysis and radiation‑induced skin toxicities assessment

フルテキストURL	fulltext20210824-1.pdf
著者	Tekiki, Nouha\| Kuroda, Masahiro\| Ishizaka, Hinata\| Khasawneh, Abdullah\| Barham, Majd\| Hamada, Kentaro\| Konishi, Kohei\| Sugimoto, Kohei\| Katsui, Kuniaki\| Sugiyama, Soichi\| Watanabe, Kenta\| Yoshio, Kotaro\| Katayama, Norihisa\| Ogata, Takeshi\| Ihara, Hiroki\| Kanazawa, Susumu\| Asaumi, Junichi\|
キーワード	breast cancer field‑in‑field radiotherapy dose reference point acute skin toxicity dose distribution high‑dose area
備考	This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License.\|
発行日	2021-7-21
出版物タイトル	Molecular and Clinical Oncology
巻	15巻
号	3号
出版者	Spandidos Publications
ISSN	2049-9450
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© Tekiki et al.
論文のバージョン	publisher
PubMed ID	34349992
DOI	10.3892/mco.2021.2355
Web of Science KeyUT	000680476900001
関連URL	isVersionOf https://doi.org/10.3892/mco.2021.2355

RUNX2 Phosphorylation by Tyrosine Kinase ABL Promotes Breast Cancer Invasion (vol 11, 665273, 2021)

フルテキストURL	fulltext.pdf
著者	He, Fang\| Matsumoto, Yoshinori\| Asano, Yosuke\| Yamamura, Yuriko\| Katsuyama, Takayuki\| Rose, Jose La\| Tomonobu, Nahoko\| Komalasari, Ni Luh Gede Yoni\| Sakaguchi, Masakiyo\| Rottapel, Robert\| Wada, Jun\|
キーワード	ABL-Abelson murine leukemia viral oncogene homolog Runx2 (runt-related transcription factor 2) tyrosine phosphorylation invasion
備考	A Corrigendum on RUNX2 Phosphorylation by Tyrosine Kinase ABL Promotes Breast Cancer Invasion By He F, Matsumoto Y, Asano Y, Yamamura Y, Katsuyama T, Rose JL, Tomonobu N, Komalasari NLGY, Sakaguchi M, Rottapel R and Wada J (2021). Front. Oncol. 11:665273. doi: 10.3389/fonc.2021.665273 Erratum for https://ousar.lib.okayama-u.ac.jp/62214\|
発行日	2021-07-20
出版物タイトル	Frontiers In Oncology
巻	11巻
出版者	Frontiers Media SA.
開始ページ	729192
ISSN	2234-943X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 He, Matsumoto, Asano, Yamamura, Katsuyama, Rose,Tomonobu, Komalasari, Sakaguchi, Rottapel and Wada.
論文のバージョン	publisher
PubMed ID	34354958
DOI	10.3389/fonc.2021.729192
Web of Science KeyUT	000680472200001
関連URL	isVersionOf https://doi.org/10.3389/fonc.2021.729192

Microenvironment of mammary fat pads affected the characteristics of the tumors derived from the induced cancer stem cells

フルテキストURL	fulltext.pdf
著者	Abu Quora, Hagar A.\| Zahra, Maram H.\| El-Ghlban, Samah\| Nair, Neha\| Afify, Said M.\| Hassan, Ghmkin\| Nawara, Hend M.\| Sheta, Mona\| Monzur, Sadia\| Fu, Xiaoying\| Osman, Amira\| Seno, Akimasa\| Seno, Masaharu\|
キーワード	Mammary fat pad microenvironment iPSCs CSCs breast cancer
発行日	2021
出版物タイトル	American Journal of Cancer Research
巻	11巻
号	7号
出版者	e-Century Publishing Corp.
開始ページ	3475
終了ページ	3495
ISSN	2156-6976
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	AJCR (c)2021 e-Century Publishing Corp.
論文のバージョン	publisher
PubMed ID	34354856
Web of Science KeyUT	000680048600006

Sarcopenia is associated with poor prognosis after chemoradiotherapy in patients with stage III non-small-cell lung cancer: a retrospective analysis

フルテキストURL	fulltext.pdf
著者	Katsui, Kuniaki\| Ogata, Takeshi\| Sugiyama, Soichi\| Yoshio, Kotaro\| Kuroda, Masahiro\| Hiraki, Takao\| Kiura, Katsuyuki\| Maeda, Yoshinobu\| Toyooka, Shinichi\| Kanazawa, Susumu\|
発行日	2021-06-04
出版物タイトル	scientific reports
巻	11巻
号	1号
出版者	Nature Research
開始ページ	11882
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2021
論文のバージョン	publisher
PubMed ID	34088965
DOI	10.1038/s41598-021-91449-z
Web of Science KeyUT	000678611200010
関連URL	isVersionOf https://doi.org/10.1038/s41598-021-91449-z

Emphysematous changes and lower levels of plasma irisin are associated with bronchiolitis obliterans syndrome after bilateral living-donor lobar lung transplantation

フルテキストURL	fulltext20210727-2.pdf
著者	Shiotani, Toshio\| Sugimoto, Seiichiro\| Yamamoto, Haruchika\| Miyoshi, Kentaroh\| Otani, Shinji\| Suzawa, Ken\| Yamamoto, Hiromasa\| Okazaki, Mikio\| Yamane, Masaomi\| Toyooka, Shinichi\|
キーワード	chronic lung allograft dysfunction emphysema irisin living-donor lung transplantation
備考	This is a post-peer-review, pre-copyedit version of an article published in Surgery Today. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00595-021-02339-w This fulltext is available in July 2022.\|
発行日	2021-7-12
出版物タイトル	Surgery Today
巻	52巻
号	2号
出版者	Springer Science and Business Media LLC
開始ページ	294
終了ページ	305
ISSN	0941-1291
NCID	AA10824685
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© Springer Nature Singapore Pte Ltd. 2021
論文のバージョン	author
PubMed ID	34251508
DOI	10.1007/s00595-021-02339-w
Web of Science KeyUT	000672249200001
関連URL	isVersionOf https://doi.org/10.1007/s00595-021-02339-w

Optimizing the timing of 3.6 mg Pegfilgrastim Administration for Dose-Dense Chemotherapy in Japanese Patients with Breast Cancer

JaLCDOI	10.18926/AMO/62231
フルテキストURL	75_3_357.pdf
著者	Takabatake, Daisuke\| Kajiwara, Yukiko\| Ohtani, Shoichiro\| Suzuki, Yoko\| Yamamoto, Mari\| Kubo, Shinichiro\| Ikeda, Masahiko\| Takahashi, Mina\| Hara, Fumikata\| Aogi, Kenjiro\| Ohsumi, Shozo\| Ogasawara, Yutaka\| Nishiyama, Yoshitaka\| Hikino, Hajime\| Matsuoka, Kinya\| Shien, Tadahiko\| Taira, Naruto\| Doihara, Hiroyoshi\|
抄録	Perioperative dose-dense chemotherapy (DDCT) with pegfilgrastim (Peg) prophylaxis is a standard treatment for high-risk breast cancer. We explored the optimal timing of administration of 3.6 mg Peg, the dose approved in Japan. In the phase II feasibility study of DDCT (adriamycin+cyclophosphamide or epirubicin+cyclophosphamide followed by paclitaxel) for breast cancer, we investigated the feasibility, safety, neutrophil transition, and optimal timing of Peg treatment by administering Peg at days 2, 3, and 4 post-chemotherapy (P2, P3, and P4 groups, respectively). Among the 52 women enrolled, 13 were aged > 60 years. The anthracycline sequence was administered to P2 (n=33), P3 (n=5), and P4 (n=14) patients, and the taxane sequence to P2 (n=38) and P3 (n=6) patients. Both sequences showed no interaction between Peg administration timing and treatment discontinuation, treatment delay, or dose reduction. However, the relative dose intensity (RDI) was significantly different among the groups. The neutrophil count transition differed significantly among the groups receiving the anthracycline sequence. However, the neutrophil count remained in the appropriate range for both sequences in the P2 group. The timing of Peg administration did not substantially affect the feasibility or safety of DDCT. Postoperative day 2 might be the optimal timing for DDCT.
キーワード	dose-dense chemotherapy breast cancer pegfilgrastim
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-06
巻	75巻
号	3号
出版者	Okayama University Medical School
開始ページ	357
終了ページ	362
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34176940
Web of Science KeyUT	000667147700011
NAID	120007089828

Texture Indices of 18F-FDG PET/CT for Differentiating Squamous Cell Carcinoma and Non-Hodgkin’s Lymphoma of the Oropharynx

JaLCDOI	10.18926/AMO/62230
フルテキストURL	75_3_351.pdf
著者	Mitamura, Katsuya\| Norikane, Takashi\| Yamamoto, Yuka\| Ihara-Nishishita, Ayumi\| Kobata, Takuya\| Fujimoto, Kengo\| Takami, Yasukage\| Kudomi, Nobuyuki\| Hoshikawa, Hiroshi\| Nishiyama, Yoshihiro\|
抄録	We assessed the role of 18F-FDG PET/CT texture indices for the differentiation of squamous cell carcinoma (SCC) and non-Hodgkin’s lymphoma (NHL) in the oropharynx. 18F-FDG PET/CT data for 27 patients with SCC and 25 patients with NHL in the oropharynx were investigated. The maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and six texture indices (homogeneity, entropy, short-run emphasis, long-run emphasis, low gray-level zone emphasis [LGZE], and high graylevel zone emphasis [HGZE]) were derived from PET images. PET/CT parameters of the SCC patients were compared with those of the NHL patients. The diagnostic accuracy of the indices for differentiating SCC from NHL was calculated by a receiver operating characteristic curve analysis. 18F-FDG uptake in the oropharynx was observed in all of the patients. The SUVmax, MTV, and TLG did not differ significantly between the SCC and NHL groups, but two of the six texture indices (LGZE [p=0.004] and HGZE [p=0.03]) showed significant differences between the groups. LGZE was the best discriminative index for the differentiation of SCC and NHL (55.6% sensitivity, 88.0% specificity). The LGZE and HGZE texture indices derived from 18F-FDG PET/CT images may be useful in differentiating SCC and NHL in the oropharynx.
キーワード	18F-FDG PET/CT oropharyngeal squamous cell carcinoma malignant lymphoma texture
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-06
巻	75巻
号	3号
出版者	Okayama University Medical School
開始ページ	351
終了ページ	356
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34176939
Web of Science KeyUT	000667147700010
NAID	120007089827

Investigation into the Effect of Breast Volume on Irradiation Dose Distribution in Asian Women with Breast Cancer

JaLCDOI	10.18926/AMO/62225
フルテキストURL	75_3_307.pdf
著者	Ishizaka, Hinata\| Kuroda, Masahiro\| Tekiki, Nouha\| Khasawneh, Abdullah\| Barham, Majd\| Hamada, Kentaro\| Konishi, Kohei\| Sugimoto, Kohei\| Katsui, Kuniaki\| Sugiyama, Soichi\| Watanabe, Kenta\| Yoshio, Kotaro \| Katayama, Norihisa\| Ogata, Takeshi\| Ihara, Hiroki\| Oita, Masataka\| Kanazawa, Susumu\| Asaumi, Junichi\|
抄録	Reports on irradiation dose distribution in breast cancer radiotherapy with sufficient sample size are limited in Asian patients. Elucidating dose distribution in Asian patients is particularly important as their breast volume differs compared to patients in Europe and North America. Here, we examined dose distribution in the irradiation field relative to breast volume for three irradiation methods historically used in our facility. We investigated the influence of breast volume on each irradiation method for Asian women. A total of 573 women with early-stage breast cancer were treated with breast-conserving surgery and adjuvant radiotherapy. Three methods were compared: wedge (W), field-in-field (FIF), and wedge-field-in-field (W-FIF). In patients with small breast volume, FIF decreased low- and high-dose areas within the planning target volume, and increased optimal dose area more than W. In patients with medium and large breast volumes, FIF decreased high-dose area more than W. The absolute values of correlation coefficients of breast volume to low-, optimal-, and high-dose areas and mean dose were significantly lower in FIF than in W. The correlation coefficients of V107% were 0.00 and 0.28 for FIF and W, respectively. FIF is an excellent irradiation method that is less affected by breast volume than W in Asian breast cancer patients.
キーワード	breast cancer radiotherapy dose distribution irradiation method breast volume
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-06
巻	75巻
号	3号
出版者	Okayama University Medical School
開始ページ	307
終了ページ	314
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34176934
Web of Science KeyUT	000667147700006
NAID	120007089838

Clinical Outcome of Palliative Concurrent Chemoradiotherapy with Cisplatin/Docetaxel for Stage III Non-small Cell Lung Cancer

JaLCDOI	10.18926/AMO/62218
フルテキストURL	75_3_269.pdf
著者	Katsui, Kuniaki\| Ogata, Takeshi\| Watanabe, Kenta\| Yoshio, Kotaro\| Kuroda, Masahiro\| Hiraki, Takao\| Kiura, Katsuyuki\| Maeda, Yoshinobu\| Toyooka, Shinichi\| Kanazawa, Susumu\|
抄録	Palliative concurrent chemoradiotherapy (CCRT) is often administered to patients with stage III non-small cell lung cancer (NSCLC). We investigated the clinical outcomes of patients receiving palliative CCRT for NSCLC. Data of patients with NSCLC who underwent palliative CCRT (n=16), preoperative CCRT plus surgery (n=97), or definitive CCRT (n=48) were evaluated. In all groups, the concurrent chemotherapy regimens consisted of cisplatin and docetaxel. Rates of local control (LC), distant metastasis-free survival (DMFS), progression-free survival (PFS), overall survival (OS), and prognosis were compared. The 2-year rates of LC, DMFS, PFS, and OS in 16 patients who underwent palliative CCRT were 44.4%, 12.5%, 12.5%, and 18.8%, respectively. Univariate analysis showed that palliative CCRT was associated with poor LC (p<0.001), DMFS (p<0.001), PFS (p<0.001), and OS (p<0.001) outcomes in patients who completed CCRT as a preoperative treatment and poor LC (p=0.01), DMFS (p=0.003), PFS (p=0.04), and OS (p=0.004) outcomes in patients who were considered for definitive CCRT. Although there were some long-term survivors, the clinical outcomes of palliative CCRT were significantly inferior to those of the ideal treatments. Therefore, careful determination of the appropriate treatment indications and further studies are warranted.
キーワード	palliative concurrent chemoradiotherapy cisplatin/docetaxel stage III non-small cell lung cancer
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2021-06
巻	75巻
号	3号
出版者	Okayama University Medical School
開始ページ	269
終了ページ	277
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	CopyrightⒸ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34176930
Web of Science KeyUT	000667147700002
NAID	120007089833