| JaLCDOI | 10.18926/AMO/62810 |
|---|---|
| フルテキストURL | 75_6_705.pdf |
| 著者 | Iwata, Takehiro| Maruyama, Yuki| Kawada, Tatsushi| Sadahira, Takuya| Katayama, Satoshi| Takamoto, Atsushi| Sako, Tomoko| Wada, Koichiro| Edamura, Kohei| Kobayashi, Yasuyuki| Araki, Motoo| Watanabe, Masami| Watanabe, Toyohiko| Nasu, Yasutomo| |
| 抄録 | Optimal neoadjuvant hormone therapy (NHT) for reducing prostate cancer (PC) patients’ prostate volume pre-brachytherapy is controversial. We evaluated the differential impact of neoadjuvant gonadotropin-releasing hormone (GnRH) antagonist versus agonist on post-brachytherapy testosterone recovery in 112 patients treated pre-brachytherapy with NHT (GnRH antagonist, n=32; GnRH agonists, n=80) (Jan. 2007-June 2019). We assessed the effects of patient characteristics and a GnRH analogue on testosterone recovery with logistic regression and a propensity score analysis (PSA). There was no significant difference in the rate of testosterone recovery to normal levels (> 300 ng/dL) between the GnRH antagonist and agonists (p=0.07). The GnRH agonists induced a significantly more rapid testosterone recovery rate at 3 months post-brachytherapy versus the GnRH antagonist (p<0.0001); there was no difference in testosterone recovery at 12 months between the GnRH antagonist/agonists (p=0.8). In the multivariate analysis, no actor was associated with testosterone recovery. In the PSA, older age and higher body mass index (BMI) were significantly associated with longer testosterone recovery. Post-brachytherapy testosterone recovery was quicker with the neoadjuvant GnRH agonists than the antagonist, and the testosterone recovery rate was significantly associated with older age and higher BMI. Long-term follow-ups are needed to determine any differential effects of GnRH analogues on the quality of life of brachytherapy-treated PC patients. |
| キーワード | testosterone recovery GnRH antagonist GnRH agonist brachytherapy prostate cancer |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2021-12 |
| 巻 | 75巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 705 |
| 終了ページ | 711 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2021 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 34955538 |
| Web of Science KeyUT | 000735297900006 |
| NAID | 120007180282 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Wada, Koichiro| Araki, Motoo| Tanimoto, Ryuta| Sadahira, Takuya| Watari, Shogo| Maruyama, Yuki| Mitsui, Yosuke| Nakajima, Hirochika| Acosta, Herik| Katayama, Satoshi| Iwata, Takehiro| Nishimura, Shingo| Takamoto, Atsushi| Sako, Tomoko| Edamura, Kohei| Kobayashi, Yasuyuki| Watanabe, Masami| Watanabe, Toyohiko| Nasu, Yasutomo| |
| キーワード | Photodynamic diagnosis 5-Aminolevulinic acid ALA-PDD Upper urinary tract urothelial carcinoma VISERA ELITE video system |
| 発行日 | 2021-03-25 |
| 出版物タイトル | BMC urology |
| 巻 | 21巻 |
| 号 | 1号 |
| 出版者 | BMC |
| 開始ページ | 45 |
| ISSN | 1471-2490 |
| NCID | AA12035460 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2021. |
| 論文のバージョン | publisher |
| PubMed ID | 33765999 |
| DOI | 10.1186/s12894-021-00819-2 |
| NAID | 120007008530 |
| Web of Science KeyUT | 000632906900001 |
| 関連URL | isVersionOf https://doi.org/10.1186/s12894-021-00819-2 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Janisch, Florian| Abufaraj, Mohammad| Fajkovic, Harun| Kimura, Shoji| Iwata, Takehiro| Nyirady, Peter| Rink, Michael| Shariat, Shahrokh F.| |
| キーワード | Disease management Primary urethral carcinoma Prognosis Therapy Treatment |
| 発行日 | 2019-07-13 |
| 出版物タイトル | European Urology Focus |
| 巻 | 5巻 |
| 号 | 5号 |
| 出版者 | Elsevier |
| 開始ページ | 722 |
| 終了ページ | 734 |
| ISSN | 24054569 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2019 European Association of Urology. Published by Elsevier B.V. |
| 論文のバージョン | publisher |
| PubMed ID | 31307949 |
| DOI | 10.1016/j.euf.2019.07.001 |
| Web of Science KeyUT | 000490140000008 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.euf.2019.07.001 |