| JaLCDOI | 10.18926/AMO/62810 |
|---|---|
| FullText URL | 75_6_705.pdf |
| Author | Iwata, Takehiro| Maruyama, Yuki| Kawada, Tatsushi| Sadahira, Takuya| Katayama, Satoshi| Takamoto, Atsushi| Sako, Tomoko| Wada, Koichiro| Edamura, Kohei| Kobayashi, Yasuyuki| Araki, Motoo| Watanabe, Masami| Watanabe, Toyohiko| Nasu, Yasutomo| |
| Abstract | Optimal neoadjuvant hormone therapy (NHT) for reducing prostate cancer (PC) patients’ prostate volume pre-brachytherapy is controversial. We evaluated the differential impact of neoadjuvant gonadotropin-releasing hormone (GnRH) antagonist versus agonist on post-brachytherapy testosterone recovery in 112 patients treated pre-brachytherapy with NHT (GnRH antagonist, n=32; GnRH agonists, n=80) (Jan. 2007-June 2019). We assessed the effects of patient characteristics and a GnRH analogue on testosterone recovery with logistic regression and a propensity score analysis (PSA). There was no significant difference in the rate of testosterone recovery to normal levels (> 300 ng/dL) between the GnRH antagonist and agonists (p=0.07). The GnRH agonists induced a significantly more rapid testosterone recovery rate at 3 months post-brachytherapy versus the GnRH antagonist (p<0.0001); there was no difference in testosterone recovery at 12 months between the GnRH antagonist/agonists (p=0.8). In the multivariate analysis, no actor was associated with testosterone recovery. In the PSA, older age and higher body mass index (BMI) were significantly associated with longer testosterone recovery. Post-brachytherapy testosterone recovery was quicker with the neoadjuvant GnRH agonists than the antagonist, and the testosterone recovery rate was significantly associated with older age and higher BMI. Long-term follow-ups are needed to determine any differential effects of GnRH analogues on the quality of life of brachytherapy-treated PC patients. |
| Keywords | testosterone recovery GnRH antagonist GnRH agonist brachytherapy prostate cancer |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-12 |
| Volume | volume75 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 705 |
| End Page | 711 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34955538 |
| Web of Science KeyUT | 000735297900006 |
| NAID | 120007180282 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Wada, Koichiro| Araki, Motoo| Tanimoto, Ryuta| Sadahira, Takuya| Watari, Shogo| Maruyama, Yuki| Mitsui, Yosuke| Nakajima, Hirochika| Acosta, Herik| Katayama, Satoshi| Iwata, Takehiro| Nishimura, Shingo| Takamoto, Atsushi| Sako, Tomoko| Edamura, Kohei| Kobayashi, Yasuyuki| Watanabe, Masami| Watanabe, Toyohiko| Nasu, Yasutomo| |
| Keywords | Photodynamic diagnosis 5-Aminolevulinic acid ALA-PDD Upper urinary tract urothelial carcinoma VISERA ELITE video system |
| Published Date | 2021-03-25 |
| Publication Title | BMC urology |
| Volume | volume21 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 45 |
| ISSN | 1471-2490 |
| NCID | AA12035460 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2021. |
| File Version | publisher |
| PubMed ID | 33765999 |
| DOI | 10.1186/s12894-021-00819-2 |
| NAID | 120007008530 |
| Web of Science KeyUT | 000632906900001 |
| Related Url | isVersionOf https://doi.org/10.1186/s12894-021-00819-2 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Janisch, Florian| Abufaraj, Mohammad| Fajkovic, Harun| Kimura, Shoji| Iwata, Takehiro| Nyirady, Peter| Rink, Michael| Shariat, Shahrokh F.| |
| Keywords | Disease management Primary urethral carcinoma Prognosis Therapy Treatment |
| Published Date | 2019-07-13 |
| Publication Title | European Urology Focus |
| Volume | volume5 |
| Issue | issue5 |
| Publisher | Elsevier |
| Start Page | 722 |
| End Page | 734 |
| ISSN | 24054569 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 European Association of Urology. Published by Elsevier B.V. |
| File Version | publisher |
| PubMed ID | 31307949 |
| DOI | 10.1016/j.euf.2019.07.001 |
| Web of Science KeyUT | 000490140000008 |
| Related Url | isVersionOf https://doi.org/10.1016/j.euf.2019.07.001 |
