result 47530 件
| JaLCDOI | 10.18926/AMO/53121 |
|---|---|
| FullText URL | 69_1_45.pdf |
| Author | Iida, Tadayuki| Inoue, Ken| Ito, Yasuhiro| Ishikawa, Hiroaki| Kagiono, Miwa| Teradaira, Ryoji| Chikamura, Chiho| Harada, Toshihide| Ezoe, Satoko| Yatsuya, Hiroshi| |
| Abstract | This study aimed to clarify the association between depressive symptoms and a marker of oxidative stress-induced DNA damage in young females. Since the menstrual cycle may confound or modify this association, depressive symptoms and urinary levels of 8-hydroxy-2ʼ deoxyguanosine (8-OHdG) were evaluated during each menstrual phase. A total of 57 female fourth-year students (aged 21.6±0.8) from a Japanese health science university were studied. The menstrual cycle was divided into 3 phases:menstrual (days 1 to 3 after the onset of menses);proliferative (days 13 to 15);and secretory (days 24 to 26). Depressive symptoms were assessed by the self-rating depression scale (SDS). Positive depressive symptoms were defined as a score of 53 or more during 2 different menstrual phases. The association between the presence of depressive symptoms and 8-OHdG levels adjusting for the menstrual cycle was examined by two-way analysis of variance with the menstrual cycle (menstrual, proliferative, and secretory phases) as the within-individual factor. The menstrual cycle did not show a significant correlation with urinary 8-OHdG levels. On the other hand, the menstrual cycle-adjusted 8-OHdG level was significantly higher in those with depressive symptoms (7.01ng/mL) than in those without them (3.98ng/mL). The ROC curve analysis showed that urinary 8-OHdG levels had reasonably high discriminative performance throughout all the menstrual cycles (0.73-0.81;all p＜0.05). These results indicated the presence of oxidative stress in subjects with depressive symptoms independent of the menstrual cycle. |
| Keywords | depression 8-OHdG menstrual cycle |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2015-02 |
| Volume | volume69 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 45 |
| End Page | 50 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25703170 |
| Web of Science KeyUT | 000349740300005 |
| JaLCDOI | 10.18926/AMO/53120 |
|---|---|
| FullText URL | 69_1_37.pdf |
| Author | Iwamuro, Masaya| Okada, Hiroyuki| Takata, Katsuyoshi| Kawai, Yoshinari| Kawano, Seiji| Nasu, Junichiro| Kawahara, Yoshiro| Tanaka, Takehiro| Yoshino, Tadashi| Yamamoto, Kazuhide| |
| Abstract | The sensitivity and specificity of magnified endoscopic features for differentiating follicular lymphoma from other diseases with duodenal whitish lesions have never been investigated. Here we compared the magnified endoscopic features of duodenal follicular lymphoma with those of other whitish lesions. We retrospectively reviewed the cases of patients with follicular lymphoma (n＝9), lymphangiectasia (n＝7), adenoma (n＝10), duodenitis (n＝4), erosion (n＝1), lymphangioma (n＝1), and hyperplastic polyp (n＝1). The magnified features of the nine follicular lymphomas included enlarged villi (n＝8), dilated microvessels (n＝5), and opaque white spots of various sizes (n＝9). The lymphangiectasias showed enlarged villi, dilated microvessels, and white spots, but the sizes of the white spots were relatively homogeneous and their margin was clear. Observation of the adenoma and duodenitis revealed only whitish villi. Although the lymphangioma was indistinguishable from the follicular lymphomas by magnified features, it was easily diagnosed based on the macroscopic morphology. In conclusion, magnified endoscopic features, in combination with macroscopic features, are useful for differentiating follicular lymphomas from other duodenal diseases presenting whitish lesions. |
| Keywords | duodenal neoplasm follicular lymphoma gastrointestinal lymphoma magnifying endoscopy |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2015-02 |
| Volume | volume69 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 37 |
| End Page | 44 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25703169 |
| Web of Science KeyUT | 000349740300004 |
| JaLCDOI | 10.18926/AMO/53119 |
|---|---|
| FullText URL | 69_1_29.pdf |
| Author | Nakahara, Ryuichi| Nishida, Keiichiro| Hashizume, Kenzo| Harada, Ryouzou| Machida, Takahiro| Horita, Masahiro| Ohtsuka, Aiji| Ozaki, Toshifumi| |
| Abstract | The outcome measures in rheumatology clinical trials (OMERACT) scores are the most mature quantitation system for rheumatoid arthritis (RA) on magnetic resonance imaging (MRI). Direct measuring techniques of synovial volume have been reported with good reproducibility, although few reports have demonstrated the changes of these measures in response to treatment. To assess these clinical responses, we evaluated the correlation of the changes of clinical activity score 28-joints disease activity score (DAS28-CRP) with the changes of OMERACT scores and with synovial volume measurements. Eight RA patients who were treated by biologic agents were examined with MRI of the dominant affected wrist and finger joints before and one year after the treatment. The total OMERACT score was reduced from 48.0 to 41.3, and synovial volume was reduced from 15.4 to 8.8 milliliters. Positive correlations were seen between the changes of DAS28-CRP and the changes of OMERACT synovitis score (r＝0.27), OMERACT total score (r＝0.43) and synovial volume (r＝0.30). Limited to synovium assessment, synovial volume showed a better correlation with DAS28-CRP than the OMERACT synovitis score. On the other hand, the OMERACT total score showed a higher correlation with DAS28-CRP than synovial volume, probably because the OMERACT total score includes scores for bone erosion and bone edema as well. |
| Keywords | magnetic resonance imaging rheumatoid arthritis outcome measures in rheumatology clinical trials scoring system direct volume measuring medical work station |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2015-02 |
| Volume | volume69 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 29 |
| End Page | 35 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25703168 |
| Web of Science KeyUT | 000349740300003 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/53113 |
| JaLCDOI | 10.18926/AMO/53118 |
|---|---|
| FullText URL | 69_1_17.pdf |
| Author | Suzuki, Norihiro| Takata, Minoru| Shirafuji, Yoshinori| Otsuka, Masaki| Yamasaki, Osamu| Asagoe, Kenji| Hatta, Naohito| Iwatsuki, Keiji| |
| Abstract | Sentinel lymph node (SLN) biopsies have widely been used for the detection of occult LN metastasis of malignant melanoma (MM). In addition to conventional biomarkers, we assessed the diagnostic and prognostic significance of melanoma-initiating cell (MIC) markers in SLNs of MM. We examined the expressions of gp100, MART-1 and tyrosinase mRNA for routine diagnosis and those of ABCB5, CD133, nestin, KDM5B, NGFR and RANK mRNA as MIC markers. The presence of micrometastasis was confirmed immunohistochemically using antibodies to S-100, HMB-45, MART-1, and tyrosinase. Discordance between immunohistochemical and molecular data was observed in 14 of 70 (20.0%) patients, among whom five (7.1%) were positive for only molecular markers;two of these five patients tested positive for micrometastasis by repeated immunohistochemical stainings. The quantitative expression levels of gp100, MART-1, and tyrosinase mRNA were significantly higher in the metastatic LNs;the cut-off values remain to be elucidated. ABCB5 mRNA expression was detected more frequently in the metastatic SLNs (p＜0.05) and in the group of patients with recurrence. To make a definite diagnosis of metastasis, we still need a combination of immunohistochemical and molecular probes. ABCB5 might be a suitable molecular marker for the detection of melanoma-initiating cells in SLNs. |
| Keywords | melanoma cancer-initiating cell sentinel lymph node ABCB5 |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2015-02 |
| Volume | volume69 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 17 |
| End Page | 27 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25703167 |
| Web of Science KeyUT | 000349740300002 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/53114 |
| JaLCDOI | 10.18926/AMO/53117 |
|---|---|
| FullText URL | 69_1_1.pdf |
| Author | Watatani, Hiroyuki| Yamasaki, Hiroko| Maeshima, Yohei| Nasu, Tatsuyo| Hinamoto, Norikazu| Ujike, Haruyo| Sugiyama, Hitoshi| Sakai, Yoshiki| Tanabe, Katsuyuki| Makino, Hirofumi| |
| Abstract | Diabetic nephropathy is the most common pathological disorder predisposing patients to end-stage renal disease. Considering the increasing prevalence of type 2 diabetes mellitus worldwide, novel therapeutic approaches are urgently needed. ONO-1301 is a novel sustained-release prostacyclin analog that inhibits thromboxane A2 synthase. Here we examined the therapeutic effects of the intermittent administration of slow-release ONO-1301 (SR-ONO) on diabetic nephropathy in obese type 2 diabetes mice, as well as its direct effects on mesangial cells. The subcutaneous injection of SR-ONO (3mg/kg) every 3 wks did not affect the obesity or hyperglycemia in the db/db obese mice used as a model of type 2 diabetes, but it significantly ameliorated their albuminuria, glomerular hypertrophy, glomerular accumulation of type IV collagen, and monocyte/macrophage infiltration, and also the increase of TGF-β1, α-smooth muscle actin (α-SMA) and MCP-1 compared to vehicle treatment. In cultured mouse mesangial cells, ONO-1301 concentration-dependently suppressed the increases in TGF-β, type IV collagen, α-SMA, MCP-1 and fibronectin induced by high ambient glucose, at least partly through prostacyclin (PGI2) receptor-mediated signaling. Taken together, these results suggest the potential therapeutic efficacy of the intermittent administration of SR-ONO against type 2 diabetic nephropathy, possibly through protective effects on mesangial cells. |
| Keywords | prostacyclin ONO-1301 diabetic nephropathy TGF-β1 diabetes mellitus |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2015-02 |
| Volume | volume69 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 1 |
| End Page | 15 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25703166 |
| Web of Science KeyUT | 000349740300001 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/53128 |
| Author | Takahashi, Kingo| |
|---|---|
| Published Date | 2012-06-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| FullText URL | K0005065_abstract_review.pdf K0005065_fulltext.pdf |
|---|---|
| Author | Tada, Kotaro| |
| Published Date | 2014-12-31 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5065号 |
| Granted Date | 2014-12-31 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | Japanese English |
| FullText URL | K0005064_abstract_review.pdf K0005064_fulltext.pdf |
|---|---|
| Author | Suzuki, Norihiro| |
| Published Date | 2014-12-31 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5064号 |
| Granted Date | 2014-12-31 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | Japanese English |
| FullText URL | K0004063_abstract_review.pdf K0004063_fultext.pdf |
|---|---|
| Author | Nakahara, Ryuichi| |
| Published Date | 2014-12-31 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5063号 |
| Granted Date | 2014-12-31 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | Japanese English |
| Author | 岡山大学経済学会| |
|---|---|
| Published Date | 2014-12-18 |
| Publication Title | 岡山大学経済学会雑誌 |
| Volume | volume46 |
| Issue | issue2 |
| Content Type | Others |
| Author | 岡山大学経済学会| |
|---|---|
| Published Date | 2014-12-18 |
| Publication Title | 岡山大学経済学会雑誌 |
| Volume | volume46 |
| Issue | issue2 |
| Content Type | Others |
| JaLCDOI | 10.18926/OER/53109 |
|---|---|
| Title Alternative | Yuhei Yabuki, Regional Marketing Networks: A New Perspective on the Local Management (Yuhikaku, 2010) |
| FullText URL | oer_046_2_273_280.pdf |
| Author | Takahashi, Shiori| |
| Publication Title | 岡山大学経済学会雑誌 |
| Published Date | 2014-12-18 |
| Volume | volume46 |
| Issue | issue2 |
| Start Page | 273 |
| End Page | 280 |
| ISSN | 0386-3069 |
| language | Japanese |
| Copyright Holders | Copyright © 2014 岡山大学経済学会 |
| File Version | publisher |
| NAID | 120005540387 |
| JaLCDOI | 10.18926/OER/53108 |
|---|---|
| FullText URL | oer_046_2_263_271.pdf |
| Author | Inuzuka, Atsushi| |
| Abstract | 本論は，Verganti, R.によって書かれた「デザイン・ドリブン・イノベーション」を批判的にレビューしたものである。著者が考える同著の主な問題点は，その稚拙な論理構成と実証的事実の乏しさにある。本論では，同コンセプトを安易に信用することの危険性を反事例を導入しながら説明し，経営学書を読む際の論理的思考の重要性を主張する。 |
| Publication Title | 岡山大学経済学会雑誌 |
| Published Date | 2014-12-18 |
| Volume | volume46 |
| Issue | issue2 |
| Start Page | 263 |
| End Page | 271 |
| ISSN | 0386-3069 |
| language | Japanese |
| Copyright Holders | Copyright © 2014 岡山大学経済学会 |
| File Version | publisher |
| NAID | 120005540386 |
| JaLCDOI | 10.18926/OER/53107 |
|---|---|
| FullText URL | oer_046_2_255_261.pdf |
| Author | Murakami, Masako| |
| Publication Title | 岡山大学経済学会雑誌 |
| Published Date | 2014-12-18 |
| Volume | volume46 |
| Issue | issue2 |
| Start Page | 255 |
| End Page | 261 |
| ISSN | 0386-3069 |
| language | Japanese |
| Copyright Holders | Copyright © 2014 岡山大学経済学会 |
| File Version | publisher |
| NAID | 120005540385 |
| JaLCDOI | 10.18926/OER/53106 |
|---|---|
| Title Alternative | Public Supports to Disaster Restoration and Reconstruction Activities: A Report on Staff Dispatch by Social Welfare Councils from Okayama to Miyagi |
| FullText URL | oer_046_2_233_253.pdf |
| Author | Yoshida, Akira| Fujii, Daiji| |
| Publication Title | 岡山大学経済学会雑誌 |
| Published Date | 2014-12-18 |
| Volume | volume46 |
| Issue | issue2 |
| Start Page | 233 |
| End Page | 253 |
| ISSN | 0386-3069 |
| Related Url | http://www.e.okayama-u.ac.jp/gakkai/ |
| language | Japanese |
| Copyright Holders | Copyright © 2014 岡山大学経済学会 |
| File Version | publisher |
| NAID | 120005540384 |
| JaLCDOI | 10.18926/OER/53105 |
|---|---|
| Title Alternative | Effects of Wage and Employment Management on the Job Satisfaction of Part-time Home Helper |
| FullText URL | oer_046_2_223_231.pdf |
| Author | Kishida, Kensaku| Tanigaki, Shizuko| |
| Publication Title | 岡山大学経済学会雑誌 |
| Published Date | 2014-12-18 |
| Volume | volume46 |
| Issue | issue2 |
| Start Page | 223 |
| End Page | 231 |
| ISSN | 0386-3069 |
| Related Url | http://www.e.okayama-u.ac.jp/gakkai/ |
| language | Japanese |
| Copyright Holders | Copyright © 2014 岡山大学経済学会 |
| File Version | publisher |
| NAID | 120005540383 |
| JaLCDOI | 10.18926/OER/53104 |
|---|---|
| Title Alternative | A Note on Pecuniary Reward, Punishment and Erratic Contribution Behavior |
| FullText URL | oer_046_2_213_221.pdf |
| Author | Yokoo, Masanori| |
| Publication Title | 岡山大学経済学会雑誌 |
| Published Date | 2014-12-18 |
| Volume | volume46 |
| Issue | issue2 |
| Start Page | 213 |
| End Page | 221 |
| ISSN | 0386-3069 |
| Related Url | http://www.e.okayama-u.ac.jp/gakkai/ |
| language | Japanese |
| Copyright Holders | Copyright © 2014 岡山大学経済学会 |
| File Version | publisher |
| NAID | 120005540382 |
| JaLCDOI | 10.18926/OER/53103 |
|---|---|
| Title Alternative | Engineering and Skill Formation in a Japanese Machinery Firm |
| FullText URL | oer_046_2_199_212.pdf |
| Author | Kawai, Kazuhisa| |
| Publication Title | 岡山大学経済学会雑誌 |
| Published Date | 2014-12-18 |
| Volume | volume46 |
| Issue | issue2 |
| Start Page | 199 |
| End Page | 212 |
| ISSN | 0386-3069 |
| Related Url | http://www.e.okayama-u.ac.jp/gakkai/ |
| language | Japanese |
| Copyright Holders | Copyright © 2014 岡山大学経済学会 |
| File Version | publisher |
| NAID | 120005540381 |
| JaLCDOI | 10.18926/OER/53102 |
|---|---|
| Title Alternative | A Study Based on a Marketing Approach Related to management of the middle-mediated organization for Industry-Academia-Government Collaboration: The Okayama Prefecture Industrial Promotion Foundation as an example |
| FullText URL | oer_046_2_177_198.pdf |
| Author | Kotani, Shogo| |
| Publication Title | 岡山大学経済学会雑誌 |
| Published Date | 2014-12-18 |
| Volume | volume46 |
| Issue | issue2 |
| Start Page | 177 |
| End Page | 198 |
| ISSN | 0386-3069 |
| language | Japanese |
| Copyright Holders | Copyright © 2014 岡山大学経済学会 |
| File Version | publisher |
| NAID | 120005540380 |
| JaLCDOI | 10.18926/OER/53101 |
|---|---|
| Title Alternative | The Possibility of Real Estate Agent as a “Networker” on the Former Elementary School Site Development Project |
| FullText URL | oer_046_2_157_176.pdf |
| Author | Makio, Keiichi| |
| Publication Title | 岡山大学経済学会雑誌 |
| Published Date | 2014-12-18 |
| Volume | volume46 |
| Issue | issue2 |
| Start Page | 157 |
| End Page | 176 |
| ISSN | 0386-3069 |
| Related Url | http://www.e.okayama-u.ac.jp/gakkai/ |
| language | Japanese |
| Copyright Holders | Copyright © 2014 岡山大学経済学会 |
| File Version | publisher |
| NAID | 120005540379 |
