result 813 件
| FullText URL | fulltext20240530-04.pdf |
|---|---|
| Author | Hyodo, Aiko| Mikami, Ayaka| Horie, Kengo| Mitoh, Yoshihiro| Ninomiya, Yuzo| Iida, Seiji| Yoshida, Ryusuke| |
| Keywords | taste recognition threshold resting saliva bicarbonate xerostomia TAS1R |
| Note | © 2024 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Jun. 2025.| |
| Published Date | 2024-09 |
| Publication Title | Archives of Oral Biology |
| Volume | volume165 |
| Publisher | Elsevier BV |
| Start Page | 106013 |
| ISSN | 0003-9969 |
| NCID | AA00548457 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 Elsevier Ltd. |
| File Version | author |
| PubMed ID | 38833772 |
| DOI | 10.1016/j.archoralbio.2024.106013 |
| Web of Science KeyUT | 001251481700001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.archoralbio.2024.106013 |
| FullText URL | K0007014_abstract_review.pdf K0007014_fulltext.pdf K0007014_summary.pdf |
|---|---|
| Author | FUKUMURA, Yuka| |
| Published Date | 2024-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第7014号 |
| Granted Date | 2024-03-25 |
| Thesis Type | Doctor of Philosophy in Dental Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © 2023 by the authors. |
| FullText URL | K0007012_abstract_review.pdf K0007012_fulltext.pdf K0007012_summary.pdf |
|---|---|
| Author | YOSHIDA, Kunihiro| |
| Published Date | 2024-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第7012号 |
| Granted Date | 2024-03-25 |
| Thesis Type | Doctor of Philosophy in Dental Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © 2023 Japanese Association for Oral Biology. |
| FullText URL | K0007008_abstract_review.pdf K0007008_fulltext.pdf K0007008_summary.pdf |
|---|---|
| Author | UMEMORI, Koki| |
| Published Date | 2024-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第7008号 |
| Granted Date | 2024-03-25 |
| Thesis Type | Doctor of Philosophy in Dental Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © 2023 The Author(s). |
| FullText URL | K0006996_abstract_review.pdf K0006996_fulltext.pdf |
|---|---|
| Author | MORI, Atsushi| |
| Published Date | 2024-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6996号 |
| Granted Date | 2024-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © 2023 by the authors. |
| FullText URL | K0006962_abstract_review.pdf K0006962_fulltext.pdf K0006962_summary.pdf |
|---|---|
| Author | KOMATSUBARA, Tadashi| |
| Published Date | 2024-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6962号 |
| Granted Date | 2024-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| FullText URL | K0006953_abstract_review.pdf K0006953_fulltext.pdf K0006953_other_figure.pdf K0006953_other1_Supplementary Figures.pdf K0006953_other2_Supplementary Table.pdf K0006953_summary.pdf |
|---|---|
| Author | YOSHIMOTO, Masashi| |
| Published Date | 2024-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6953号 |
| Granted Date | 2024-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © 2023 Elsevier B.V. |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nishihara, Takahiro| Miyoshi, Toru| Nakashima, Mitsutaka| Miki, Takashi| Toda, Hironobu| Yoshida, Masatoki| Ichikawa, Keishi| Osawa, Kazuhiro| Yuasa, Shinsuke| |
| Keywords | Metabolic dysfunction-associated fatty liver disease Coronary computed tomography angiography High-risk plaque Obstructive stenosis |
| Note | The version of record of this article, first published in Cardiovascular Diabetology, is available online at Publisher’s website: http://dx.doi.org/10.1186/s12933-024-02268-1| |
| Published Date | 2024-05-10 |
| Publication Title | Cardiovascular Diabetology |
| Volume | volume23 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 167 |
| ISSN | 1475-2840 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024. |
| File Version | publisher |
| PubMed ID | 38730426 |
| DOI | 10.1186/s12933-024-02268-1 |
| Web of Science KeyUT | 001218501800001 |
| Related Url | isVersionOf https://doi.org/10.1186/s12933-024-02268-1 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yoshida, Atsuki| Ito, Ayumi| Yasui, Norihisa| Yamashita, Atsuko| |
| Keywords | calmodulin cytosol sweet taste taste receptor type 1 umami taste |
| Published Date | 2023-08-01 |
| Publication Title | The Journal of Biochemistry |
| Volume | volume174 |
| Issue | issue5 |
| Publisher | Oxford University Press (OUP) |
| Start Page | 451 |
| End Page | 459 |
| ISSN | 0021-924X |
| NCID | AA00694073 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| PubMed ID | 37527916 |
| DOI | 10.1093/jb/mvad060 |
| Web of Science KeyUT | 001044633000001 |
| Related Url | isVersionOf https://doi.org/10.1093/jb/mvad060 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Takagi, Kosei| Umeda, Yuzo| Yoshida, Ryuichi| Fuji, Tomokazu| Yasui, Kazuya| Yagi, Takahito| Fujiwara, Toshiyoshi| |
| Keywords | Hepaticojejunostomy Robotic surgery Pancreatoduodenectomy Biliary complications |
| Note | The version of record of this article, first published in Langenbeck's Archives of Surgery, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00423-023-03020-1| |
| Published Date | 2023-07-20 |
| Publication Title | Langenbeck's Archives of Surgery |
| Volume | volume408 |
| Issue | issue1 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 284 |
| ISSN | 1435-2451 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 37468703 |
| DOI | 10.1007/s00423-023-03020-1 |
| Web of Science KeyUT | 001032102900001 |
| Related Url | isVersionOf https://doi.org/10.1007/s00423-023-03020-1 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Takagi, Kosei| Hata, Nanako| Kimura, Jiro| Kikuchi, Satoru| Noma, Kazuhiro| Yasui, Kazuya| Fuji, Tomokazu| Yoshida, Ryuichi| Umeda, Yuzo| Yagi, Takahito| Fujiwara, Toshiyoshi| |
| Keywords | Virtual reality Robotic simulations Educational video Robotic surgery Learning curve Cumulative sum analysis |
| Note | The version of record of this article, first published in Journal of Robotic Surgery, is available online at Publisher’s website: http://dx.doi.org/10.1007/s11701-023-01556-4| |
| Published Date | 2023-03-11 |
| Publication Title | Journal of Robotic Surgery |
| Volume | volume17 |
| Issue | issue4 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 1547 |
| End Page | 1553 |
| ISSN | 1863-2491 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 36905486 |
| DOI | 10.1007/s11701-023-01556-4 |
| Web of Science KeyUT | 000946947400001 |
| Related Url | isVersionOf https://doi.org/10.1007/s11701-023-01556-4 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Uotani, Koji| Tazawa, Hiroshi| Hasei, Joe| Fujiwara, Tomohiro| Yoshida, Aki| Yamakawa, Yasuaki| Omori, Toshinori| Sugiu, Kazuhisa| Komatsubara, Tadashi| Kondo, Hiroya| Morita, Takuya| Kiyono, Masahiro| Yokoo, Suguru| Hata, Toshiaki| Kunisada, Toshiyuki| Takeda, Ken| Urata, Yasuo| Fujiwara, Toshiyoshi| Ozaki, Toshifumi| |
| Published Date | 2024-02-20 |
| Publication Title | PLoS ONE |
| Volume | volume19 |
| Issue | issue2 |
| Publisher | Public Library of Science |
| Start Page | e0298292 |
| ISSN | 1932-6203 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 Uotani et al. |
| File Version | publisher |
| PubMed ID | 38377118 |
| DOI | 10.1371/journal.pone.0298292 |
| Web of Science KeyUT | 001176939600021 |
| Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0298292 |
| JaLCDOI | 10.18926/AMO/66924 |
|---|---|
| FullText URL | 78_2_151.pdf |
| Author | Komatsubara, Tadashi| Tazawa, Hiroshi| Hasei, Joe| Omori, Toshinori| Sugiu, Kazuhisa| Mochizuki, Yusuke| Demiya, Koji| Yoshida, Aki| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi| |
| Abstract | Soft-tissue sarcoma (STS) is a heterogeneous group of rare tumors originating predominantly from the embryonic mesoderm. Despite the development of combined modalities including radiotherapy, STSs are often refractory to antitumor modalities, and novel strategies that improve the prognosis of STS patients are needed. We previously demonstrated the therapeutic potential of two telomerase-specific replication-competent oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in human STS cells. Here, we demonstrate in vitro and in vivo antitumor effects of OBP-702 in combination with ionizing radiation against human STS cells (HT1080, NMS-2, SYO-1). OBP-702 synergistically promoted the antitumor effect of ionizing radiation in the STS cells by suppressing the expression of B-cell lymphoma-X large (BCL-xL) and enhancing ionizing radiation-induced apoptosis. The in vivo experiments demonstrated that this combination therapy significantly suppressed STS tumors’ growth. Our results suggest that OBP-702 is a promising antitumor reagent for promoting the radiosensitivity of STS tumors. |
| Keywords | soft-tissue sarcoma radiotherapy oncolytic adenovirus p53 BCL-xL |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 151 |
| End Page | 161 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688833 |
| Web of Science KeyUT | 001229151800007 |
| JaLCDOI | 10.18926/AMO/66923 |
|---|---|
| FullText URL | 78_2_143.pdf |
| Author | Shigematsu, Hisayuki| Yamashita, Natsumi| Suehisa, Hiroshi| Ueno, Tsuyoshi| Ryuko, Tsuyoshi| Sugihara, Takahito| Nakashima, Shohei| Sano, Yoshifumi| Yamashita, Motohiro| |
| Abstract | Travel burden is a poor prognostic factor for many cancers worldwide because it hinders optimal diagnosis and treatment planning. Currently, the impact of travel burden on survival after surgery for non-small cell lung cancer (NSCLC) in Japan is largely unexplored. We examined the impact of travel distance on the postoperative outcomes of patients with NSCLC in Ehime Prefecture, Japan. The data of 1212 patients who underwent surgical resection for NSCLC were retrospectively reviewed. Patients were divided into quartiles based on the travel distance from their home to the hospital (≤ 13 km, 13-40 km, 40-57 km, and > 57 km) in Ehime Prefecture. We found no significant differences among the quartiles in baseline clinicopathological characteristics, including sex, smoking status, histology, surgical procedure, clinical stage, and pathological stage. Overall survival (OS) and relapse-free survival (RFS) also were not significantly different among the travel distance quartiles. We conclude that travel distance did not impact OS or RFS among patients with NSCLC who underwent surgical resection at our institution. |
| Keywords | non-small cell lung cancer travel distance travel burden lung surgery surgical outcome |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 143 |
| End Page | 149 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688832 |
| Web of Science KeyUT | 001229151800006 |
| JaLCDOI | 10.18926/AMO/66912 |
|---|---|
| FullText URL | 78_2_095.pdf |
| Author | Itano, Junko| Kiura, Katsuyuki| Maeda, Yoshinobu| Miyahara, Nobuaki| |
| Abstract | The lungs are very complex organs, and the respiratory system performs the dual roles of repairing tissue while protecting against infection from various environmental stimuli. Persistent external irritation disrupts the immune responses of tissues and cells in the respiratory system, ultimately leading to respiratory disease. Neuropeptide Y (NPY) is a 36-amino-acid polypeptide and a neurotransmitter that regulates homeostasis. The NPY receptor is a seven-transmembrane-domain G-protein-coupled receptor with six subtypes (Y1, Y2, Y3, Y4, Y5, and Y6). Of these receptors, Y1, Y2, Y4, and Y5 are functional in humans, and Y1 plays important roles in the immune responses of many organs, including the respiratory system. NPY and the Y1 receptor have critical roles in the pathogenesis of asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis. The effects of NPY on the airway immune response and pathogenesis differ among respiratory diseases. This review focuses on the involvement of NPY in the airway immune response and pathogenesis of various respiratory diseases. |
| Keywords | neuropeptide y Y1 receptor airway immune response bronchial epithelial cells respiratory disease |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 95 |
| End Page | 106 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688827 |
| Web of Science KeyUT | 001229151800001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Asada, Noboru| Ando, Jun| Takada, Satoru| Yoshida, Chikashi| Usuki, Kensuke| Shinagawa, Atsushi| Ishizawa, Kenichi| Miyamoto, Toshihiro| Iida, Hiroatsu| Dobashi, Nobuaki| Okubo, Sumiko| Honda, Hideyuki| Soshin, Tomomi| Nishimura, Yasuko| Tsutsui, Atsuko| Mukai, Harumi| Yamamoto, Kazuhito| |
| Keywords | acute myeloid leukemia venetoclax low-dose cytarabine expanded access study tumor lysis syndrome |
| Published Date | 2023-04-04 |
| Publication Title | Japanese Journal of Clinical Oncology |
| Volume | volume53 |
| Issue | issue7 |
| Publisher | Oxford University Press (OUP) |
| Start Page | 595 |
| End Page | 603 |
| ISSN | 1465-3621 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| PubMed ID | 37017320 |
| DOI | 10.1093/jjco/hyad027 |
| Web of Science KeyUT | 000963113000001 |
| Related Url | isVersionOf https://doi.org/10.1093/jjco/hyad027 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yoshida, Akari| Ohtsuka, Satomi| Matsumoto, Fumiya| Miyagawa, Tomoyuki| Okino, Rei| Ikeda, Yumeya| Tada, Natsume| Gotoh, Akira| Magari, Masaki| Hatano, Naoya| Morishita, Ryo| Satoh, Ayano| Sunatsuki, Yukinari| Nilsson, Ulf J.| Ishikawa, Teruhiko| Tokumitsu, Hiroshi| |
| Note | The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-024-57051-9| |
| Published Date | 2024-03-20 |
| Publication Title | Scientific Reports |
| Volume | volume14 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 6723 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024 |
| File Version | publisher |
| PubMed ID | 38509168 |
| DOI | 10.1038/s41598-024-57051-9 |
| Web of Science KeyUT | 001192455600061 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-024-57051-9 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakamitsu, Yuki| Kuroda, Masahiro| Shimizu, Yudai| Kuroda, Kazuhiro| Yoshimura, Yuuki| Yoshida, Suzuka| Nakamura, Yoshihide| Fukumura, Yuka| Kamizaki, Ryo| Al-Hammad, Wlla E.| Oita, Masataka| Tanabe, Yoshinori| Sugimoto, Kohei| Sugianto, Irfan| Barham, Majd| Tekiki, Nouha| Asaumi, Junichi| |
| Keywords | diffusion-weighted image Gaussian filter head and neck tumor magnetic resonance imaging mean kurtosis median filter nonlocal mean filter phantom simple diffusion kurtosis imaging restricted diffusion-weighted image |
| Published Date | 2024-03-20 |
| Publication Title | Journal of Clinical Medicine |
| Volume | volume13 |
| Issue | issue6 |
| Publisher | MDPI |
| Start Page | 1783 |
| ISSN | 2077-0383 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the authors. |
| File Version | publisher |
| PubMed ID | 38542005 |
| DOI | 10.3390/jcm13061783 |
| Web of Science KeyUT | 001192756600001 |
| Related Url | isVersionOf https://doi.org/10.3390/jcm13061783 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hotta, Yoshifumi| Nishida, Keiichiro| Yoshida, Aki| Nasu, Yoshihisa| Nakahara, Ryuichi| Naniwa, Shuichi| Shimizu, Noriyuki| Ichikawa, Chinatsu| Lin, Deting| Fujiwara, Tomohiro| Ozaki, Toshifumi| |
| Keywords | osteoarthritis chondrocyte mechanical stress tankyrases XAV939 SOX9 ADAMTS-5 MMP-13 IL-1β NF-κB β-catenin |
| Published Date | 2024-01-24 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume25 |
| Issue | issue3 |
| Publisher | MDPI |
| Start Page | 1443 |
| ISSN | 1661-6596 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the authors. |
| File Version | publisher |
| PubMed ID | 38338721 |
| DOI | 10.3390/ijms25031443 |
| Web of Science KeyUT | 001161430700001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms25031443 |
| JaLCDOI | 10.18926/AMO/66670 |
|---|---|
| FullText URL | 78_1_047.pdf |
| Author | Shimomura, Manabu| Shinozaki, Katsunori| Yano, Takuya| Akabane, Shintaro| Ohdan, Hideki| Hiroshima Surgical study group of Clinical Oncology (HiSCO)| |
| Abstract | Oral fluoropyrimidines (FUs) have certain advantages over intravenous FUs, such as longer intervals between outpatient visits, no requirement for central venous port (CVP) implantation, and lower incidence of neutropenia. We previously reported the efficacy of S-1/oxaliplatin (SOX) with bevacizumab therapy as a first-line treatment for advanced colorectal cancer (CRC) in a prospective phase-II multi-institutional clinical trial (HiSCO-02 study). However, our prognostic data at the time lacked a sufficient observation period. Herein, we analyze the longer-term follow-up data, focusing on the status of eventual CVP implantation via an open-label, non-randomized, multicenter study. This study enrolled 55 patients (mean age, 64 years), of whom 43 died (41 of primary cancer). The median overall survival was 22.7 months (95% CI: 20.1-34.7 months). Post-treatment regimens after failure of first-line treatment were initiated in 43 patients; CPT11-based regimens were selected in most cases, and other oral FU combinations in nine. CVP was implanted in 35 patients prior to first-line treatment; eleven of the remaining 20 patients did not require CVP implantation. In conclusion, we report here the final prognostic update of the Phase II clinical trial examining the efficacy of SOX plus bevacizumab therapy, the results of which confirm the clinical efficacy of this regimen. |
| Keywords | metastatic colorectal cancer chemotherapy S-1 prospective phase II study |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-02 |
| Volume | volume78 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 47 |
| End Page | 52 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38419314 |
| Web of Science KeyUT | 001203658200005 |
